@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu24730: (2016-07-09 )
MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLKKRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEESLVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQYAKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRDAETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDLACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIRKGIALGYLTTNNYDRWVYHEKD
Atome Classification :
(20 SA)
-------------------.........10......-..20.....----...30.........40.--.....---..50.....--.-..60........70..-......80...-.-....90...-..---...100.....----..110.-....--..---120.--.....------.130.......---140.......150.....-..160.......170......----.-180----......-----.---190..---.....200...-....210.......220.......230.......240.......250.-....------..260-----.......-----..270.......280..---------------------......290.......300....-.-..310.......320---------.---........330......-.340.......350....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------MD
S
I
E
K
V
S
K
N
L
I
E
E
A
YL-TKAS
D
I
H
I
V----PRER-
D
A
I
I
H
F
RV
D
H
A
L
--
L
K
KRD---M
K
K
E
E
C
V
R
L
--
I
-
S
H
F
K
F
L
S
AMDIGERRK-PQNG
S
L
T
L
K
LK-E-G
N
V
H
L
R
M
ST-LP---TINEE
S
L
V
I
R
V
----MPQYNI-PSI
D
--
K
L---SLFP--KT
G
A
T
------
L
L
S
F
L
K
HSH
G
M
---
L
I
F
TGPTGSG
K
T
T
T
L
Y
S
L
-
V
Q
Y
A
K
K
HFNR
N
I
V
TLEDPVET----R-DE
D
----
V
L
Q
V
Q
V-----N---EKAGV---
T
Y
S
A
G
L
K
A
I
L
R-HDP
D
M
I
I
L
G
EIRDAE
T
A
E
I
A
V
R
A
A
MTG
H
L
V
L
T
S
LHTRDA
K
G
A
I
Y
R
L
L
E
-FGI
N
------
M
N
E
-------
I
E
Q
T
V
I
A
-----
I
A
A
Q
R
L
V
D
L
A
C
P
F
C
-EN---------------------GCS
S
V
Y
C
RQSRNT
R
R
A
S
V
Y
E
L
L
Y
-
G
-
K
N
L
Q
Q
C
I
Q
E
AKGN-----------H---ANY
Q
Y
Q
T
L
R
Q
I
I
R
KG
I
A
-
L
G
Y
L
TTNNYD
R
W
V
Y
HEKD
42
HHSearch
84.74
36%
-35
- C3 -
1P9R
2
GSPE_VIBCH
A:
[32-410]
---------------------
P
I
I
K
L
I
N
A
M
L
G
E
A
I
K
-
E
G
A
S
D
I
H
I
E
----
T
F
E
K
-
T
L
S
I
R
F
R
V
D
G
V
L
--
R
E
V
L
A
---
P
S
R
K
L
S
S
L
L
--
V
-
S
R
V
K
V
M
A
K
L
D
I
A
E
K
R
V
-
P
Q
D
G
R
I
S
L
-------
A
V
D
V
R
V
S
T
-
M
P
---
S
S
H
G
E
R
V
V
M
R
L
----
L
D
K
N
A
T
R
L
D
L
H
--
S
L
---
G
M
T
A
--
H
N
H
D
N
------
F
R
R
L
I
K
R
P
H
G
I
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
-
L
Q
E
L
N
S
-
S
E
R
N
I
L
T
V
E
D
P
I
E
F
----
D
-
I
D
G
----
I
G
Q
T
Q
V
-----
N
---
P
R
V
D
M
---
T
F
A
R
G
L
R
A
I
L
R
-
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
D
-
M
G
I
E
------
P
F
L
-------
I
S
S
S
L
L
G
-----
V
L
A
Q
R
L
V
R
T
L
C
P
D
C
-
K
E
P
Y
E
A
D
K
E
Q
R
K
L
FE
P
L
I
L
Y
R
A
T
G
C
P
--
K
C
N
H
K
G
Y
R
G
R
T
G
I
H
E
L
L
L
V
D
-
D
A
L
Q
E
L
--
I
H
S
E
A
G
E
Q
A
M
E
K
----
H
---
I
R
A
T
T
P
S
I
R
D
D
G
L
D
K
V
R
-
Q
G
I
T
S
L
E
E
V
M
R
G
S
-----
40
HHSearch
84.11
36%
-39
- C3 -
4PHT
3
?
A:
[119-498]
---------------------
P
I
I
K
L
I
N
A
M
L
G
E
A
I
K
-
E
G
A
S
D
I
H
I
E
----
T
F
E
K
-
I
L
S
I
R
F
R
V
D
G
V
L
--
R
D
V
L
S
---
P
S
R
K
L
A
P
L
L
--
V
-
S
R
V
K
V
M
A
K
L
D
I
A
E
K
R
V
-
P
Q
D
G
R
I
S
L
-------
A
V
D
V
R
V
S
T
-
M
P
---
S
S
H
G
E
R
V
V
M
R
L
----
L
D
K
N
A
T
R
L
D
L
H
--
S
L
---
G
M
T
P
--
V
N
H
D
N
------
F
R
H
L
I
S
R
P
H
G
I
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
-
L
Q
E
L
N
S
-
N
E
R
N
I
L
T
V
E
D
P
I
E
F
----
D
-
I
D
G
----
I
G
Q
T
Q
V
-----
N
---
P
K
V
D
M
---
T
F
A
R
G
L
R
A
I
L
R
-
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
V
M
S
T
L
H
T
N
T
A
V
G
A
I
T
R
L
R
D
-
M
G
I
E
------
P
F
L
-------
I
S
S
S
L
L
G
-----
V
L
A
Q
R
L
V
R
T
L
C
Q
D
C
-
K
E
P
Y
E
A
D
K
E
Q
R
K
L
FA
L
T
L
Y
R
A
K
-
G
C
E
--
K
C
N
H
K
G
Y
R
G
R
T
G
I
H
E
L
L
M
V
D
-
D
K
V
Q
E
L
--
I
H
A
E
A
G
E
Q
A
M
D
K
----
Y
---
I
R
E
H
T
P
S
I
R
S
D
G
L
D
K
V
L
-
Q
G
V
T
S
L
E
E
V
M
R
V
T
K
----
1
PsiBlast_PDB
74.11
37%
-32
- C3 -
4PHT
3
?
A:
[120-439]
----------------------
I
I
K
L
I
N
A
M
L
G
E
A
I
K
-
E
G
A
S
D
I
H
I
E
----
T
F
E
K
-
I
L
S
I
R
F
R
V
D
G
V
L
--
R
D
V
L
S
---
P
S
R
K
L
A
P
L
L
--
V
-
S
R
V
K
V
M
A
K
L
D
I
A
E
K
R
V
-
P
Q
D
G
R
I
S
L
-------
A
V
D
V
R
V
S
T
-
M
P
---
S
S
H
G
E
R
V
V
M
R
L
----
L
D
K
-
N
A
-
T
R
L
D
LH
S
L
---
G
M
T
P
--
V
N
H
D
N
------
F
R
H
L
I
S
R
P
H
G
I
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
-
L
Q
E
L
N
S
N
-
E
R
N
I
L
T
V
E
D
P
I
E
F
----
D
-
I
D
G
----
I
G
Q
T
Q
V
-----
N
---
P
K
V
D
M
---
T
F
A
R
G
L
R
A
I
L
R
-
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
V
M
S
T
L
H
T
N
T
A
V
G
A
I
T
R
L
R
D
-
M
G
I
E
------
P
F
L
-------
I
S
S
S
L
L
G
-----
V
L
A
Q
R
L
V
R
T
L
C
Q
D
C
K
E
P
---------------------
Y
E
A
D
K
E
Q
R
K
L
F
------
A
L
T
L
Y
R
-
A
-
K
G
C
E
K
C
------
N
-----------
H
---
K
G
Y
R
G
R
T
-----------------------------
22
PsiBlast_CBE
73.17
37%
-34
- C3 -
4PHT
3
?
B:
[120-439]
----------------------
I
I
K
L
I
N
A
M
L
G
E
A
I
K
-
E
G
A
S
D
I
H
I
E
----
T
F
E
K
-
I
L
S
I
R
F
R
V
D
G
V
L
--
R
D
V
L
S
---
P
S
R
K
L
A
P
L
L
--
V
-
S
R
V
K
V
M
A
K
L
D
I
A
E
K
R
V
-
P
Q
D
G
R
I
S
L
-------
A
V
D
V
R
V
S
T
-
M
P
---
S
S
H
G
E
R
V
V
M
R
L
----
L
D
K
-
N
A
-
T
R
L
D
LH
S
L
---
G
M
T
P
--
V
N
H
D
N
------
F
R
H
L
I
S
R
P
H
G
I
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
-
L
Q
E
L
N
S
N
-
E
R
N
I
L
T
V
E
D
P
I
E
F
----
D
-
I
D
G
----
I
G
Q
T
Q
V
-----
N
---
P
K
V
D
M
---
T
F
A
R
G
L
R
A
I
L
R
-
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
V
M
S
T
L
H
T
N
T
A
V
G
A
I
T
R
L
R
D
-
M
G
I
E
------
P
F
L
-------
I
S
S
S
L
L
G
-----
V
L
A
Q
R
L
V
R
T
L
C
Q
D
C
K
E
P
---------------------
Y
E
A
D
K
E
Q
R
K
L
F
-----
D
A
L
T
L
Y
R
-
A
-
K
G
C
E
K
C
------
N
-----------
H
---
K
G
Y
R
G
R
T
-----------------------------
21
PsiBlast_CBE
73.17
37%
-35
- C3 -
4PHT
3
?
C:
[120-439]
----------------------
I
I
K
L
I
N
A
M
L
G
E
A
I
K
-
E
G
A
S
D
I
H
I
E
----
T
F
E
K
-
I
L
S
I
R
F
R
V
D
G
V
L
--
R
D
V
L
S
---
P
S
R
K
L
A
P
L
L
--
V
-
S
R
V
K
V
M
A
K
L
D
I
A
E
K
R
V
-
P
Q
D
G
R
I
S
L
-------
A
V
D
V
R
V
S
T
-
M
P
---
S
S
H
G
E
R
V
V
M
R
L
----
L
D
K
-
N
A
-
T
R
L
D
LH
S
L
---
G
M
T
P
--
V
N
H
D
N
------
F
R
H
L
I
S
R
P
H
G
I
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
-
L
Q
E
L
N
S
N
-
E
R
N
I
L
T
V
E
D
P
I
E
F
----
D
-
I
D
G
----
I
G
Q
T
Q
V
-----
N
---
P
K
V
D
M
---
T
F
A
R
G
L
R
A
I
L
R
-
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
V
M
S
T
L
H
T
N
T
A
V
G
A
I
T
R
L
R
D
-
M
G
I
E
------
P
F
L
-------
I
S
S
S
L
L
G
-----
V
L
A
Q
R
L
V
R
T
L
C
Q
D
C
K
E
P
---------------------
Y
E
A
D
K
E
Q
R
K
L
F
-----
D
A
L
T
L
Y
R
-
A
-
K
G
C
E
K
C
------
N
-----------
H
---
K
G
Y
R
G
R
T
-----------------------------
3
PsiBlast_PDB
71.25
40%
-41
- C3 -
4KSR
-
GSPE_VIBCH
A:
[123-423]
----------------------
I
I
K
L
I
N
A
M
L
G
E
A
I
K
-
E
G
A
S
D
I
H
I
E
----
T
F
E
K
-
T
L
S
I
R
F
R
V
D
G
V
L
--
R
E
V
L
A
---
P
S
R
K
L
S
S
L
L
--
V
-
S
R
V
K
V
M
A
K
L
D
I
A
E
K
R
V
-
P
Q
D
G
R
I
S
L
-------
A
V
D
V
R
V
S
T
-
M
P
---
S
S
H
G
E
R
V
V
M
R
L
----
L
D
K
-------
D
LH
S
L
---
G
M
T
A
--
H
N
H
D
N
------
F
R
R
L
I
K
R
P
H
G
I
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
-
L
Q
E
L
N
S
S
-
E
R
N
I
L
T
V
E
D
P
I
E
F
----
D
-
I
D
G
----
I
G
Q
T
Q
V
-----
N
---
P
R
V
D
M
---
T
F
A
R
G
L
R
A
I
L
R
-
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
D
-
M
G
I
E
------
P
F
L
-------
I
S
S
S
L
L
G
-----
V
L
A
Q
R
L
V
R
T
L
C
P
D
C
-
K
----------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
70.45
40%
-38
- C3 -
4KSS
-
GSPE_VIBCH
A:
[123-421]
----------------------
I
I
K
L
I
N
A
M
L
G
E
A
I
K
-
E
G
A
S
D
I
H
I
E
----
T
F
E
K
-
T
L
S
I
R
F
R
V
D
G
V
L
--
R
E
V
L
A
---
P
S
R
K
L
S
S
L
L
--
V
-
S
R
V
K
V
M
A
K
L
D
I
A
E
K
R
V
-
P
Q
D
G
R
I
S
L
-------
A
V
D
V
R
V
S
T
-
M
P
---
S
S
H
G
E
R
V
V
M
R
L
----
L
D
K
-------
D
LH
S
L
---
G
M
T
A
--
H
N
H
D
N
------
F
R
R
L
I
K
R
P
H
G
I
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
-
L
Q
E
L
N
S
S
-
E
R
N
I
L
T
V
E
D
P
I
E
F
----
D
-
I
D
G
----
I
G
Q
T
Q
V
-----
N
---
P
R
V
D
M
---
T
F
A
R
G
L
R
A
I
L
R
-
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
D
-
M
G
I
E
------
P
F
L
-------
I
S
S
S
L
L
G
-----
V
L
A
Q
R
L
V
R
T
L
C
P
D
C
-
K
----------------------------------------------------------------------------------------------------------------
43
HHSearch
66.37
28%
2
- C3 -
5FL3
3
?
A:
[10-354]
------------------------
Q
S
L
V
E
M
L
K
A
M
V
Q
-
A
R
A
S
D
I
H
L
Q
----
A
----
G
A
P
P
T
V
R
I
D
G
K
L
--
R
P
F
G
N
R
P
-
L
T
P
K
E
V
E
A
I
--
A
-
R
A
L
L
T
P
E
Q
L
E
E
L
E
Y
R
K
-
E
M
D
F
A
Y
T
I
--
P
---
G
V
A
R
F
R
C
N
L
-
L
R
---
Q
R
G
S
F
G
L
V
M
R
V
----
V
S
E
V
I
P
--
S
F
E
--
A
L
---
G
L
P
R
--
E
V
M
---------
E
S
L
A
A
K
E
R
G
L
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
L
-
I
D
H
I
N
L
H
Y
A
K
N
I
I
T
I
E
D
P
I
E
F
----
L
-
H
K
H
----
K
K
S
L
V
V
-----
Q
R
E
V
G
L
D
T
D
---
S
F
Y
T
G
L
K
Y
A
L
R
-
Q
D
P
D
V
I
M
V
G
E
M
R
D
R
E
T
V
E
A
A
L
M
A
A
Q
T
G
H
L
V
L
S
T
L
H
T
L
D
A
W
R
T
I
N
R
I
I
D
-
F
F
P
L
HE
H
R
Q
V
R
V
L
-------
L
A
E
S
L
L
G
-----
I
L
S
Q
R
L
L
P
K
A
D
G
--------------------------------------
Q
G
R
V
L
A
L
E
I
L
I
-
A
T
P
Y
V
R
E
L
--
L
K
D
E
E
KTPQ
I
K
E
A
---
M
M
E
G
S
L
Y
G
M
R
T
F
D
Q
H
L
V
E
L
Y
T
-
E
G
L
I
S
L
E
D
A
L
S
A
A
T
S
P
H
-
4
PsiBlast_PDB
64.30
41%
1
- C3 -
1P9R
2
GSPE_VIBCH
A:
[43-316]
--------------------------------
E
A
I
K
-
E
G
A
S
D
I
H
I
E
----
T
F
E
K
-
T
L
S
I
R
F
R
V
D
G
V
L
--
R
E
V
L
A
---
P
S
R
K
L
S
S
L
L
--
V
-
S
R
V
K
V
M
A
K
L
D
I
A
E
K
R
V
-
P
Q
D
G
R
I
S
L
-------
A
V
D
V
R
V
S
T
-
M
P
---
S
S
H
G
E
R
V
V
M
R
L
----
L
D
K
-
N
A
-
T
R
L
D
--
L
H
---
S
L
------
G
M
T
A
H
N
H
D
N
F
R
R
L
I
K
R
P
H
G
I
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
-
L
Q
E
L
N
S
S
-
E
R
N
I
L
T
V
E
D
P
I
E
F
----
D
-
I
D
G
----
I
G
Q
T
Q
V
-----
N
---
P
R
V
D
M
---
T
F
A
R
G
L
R
A
I
L
R
-
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
D
-
M
G
I
E
------
P
F
L
-------
I
S
S
S
L
L
G
-----
V
L
A
Q
R
L
V
R
T
L
C
P
D
C
-
K
----------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.34
41%
3
- C3 -
1P9W
2
GSPE_VIBCH
A:
[43-316]
--------------------------------
E
A
I
K
-
E
G
A
S
D
I
H
I
E
----
T
F
E
K
-
T
L
S
I
R
F
R
V
D
G
V
L
--
R
E
V
L
A
---
P
S
R
K
L
S
S
L
L
--
V
-
S
R
V
K
V
M
A
K
L
D
I
A
E
K
R
V
-
P
Q
D
G
R
I
S
L
R
I
G
----
A
V
D
V
R
V
S
T
-
M
P
---
S
S
H
G
E
R
V
V
M
R
L
----
L
D
K
-
N
A
-
T
R
L
D
--
L
H
---
S
L
------
G
M
T
A
H
N
H
D
N
F
R
R
L
I
K
R
P
H
G
I
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
-
L
Q
E
L
N
S
S
-
E
R
N
I
L
T
V
E
D
P
I
E
F
----
D
-
I
D
G
----
I
G
Q
T
Q
V
-----
N
---
P
R
V
D
M
---
T
F
A
R
G
L
R
A
I
L
R
-
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
D
-
M
G
I
E
------
P
F
L
-------
I
S
S
S
L
L
G
-----
V
L
A
Q
R
L
V
R
T
L
C
P
D
C
-
K
----------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.85
30%
23
- C3 -
2EWW
1
?
A:
[18-347]
-----------------------------
I
I
K
E
A
I
E
-
L
G
A
S
D
I
H
L
T
A
GA
P
P
A
V
R
I
D
G
Y
I
K
F
L
K
D
F
P
R
--
L
T
P
E
D
---
T
Q
K
------------
L
A
Y
S
V
M
S
E
K
H
R
Q
K
L
-
E
E
N
G
Q
V
D
F
S
F
G
V
R
-
G
V
G
R
F
R
A
N
V
-
F
Y
---
Q
R
G
S
V
A
A
A
L
R
S
----
L
P
A
-
E
I
-
P
E
F
K
--
K
L
---
G
L
P
D
--
K
----------
V
L
E
L
C
H
R
K
M
G
L
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
-
I
D
Y
I
N
Q
T
K
S
Y
H
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
-
K
S
I
----
V
N
Q
R
E
V
-----
G
---
E
D
T
K
----
S
F
A
D
A
L
R
A
A
L
R
-
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
D
I
F
P
L
N
------
Q
Q
E
-------
Q
V
R
I
V
L
S
F
I
LQ
G
I
I
S
Q
R
L
L
----
P
K
I
-
G
G
---------------------
G
R
V
L
A
Y
E
L
L
I
P
N
T
---
A
I
R
N
L
I
R
-
E
-
N
K
L
Q
Q
V
Y
S
L
M
Q
---------------------
M
Q
T
M
N
Q
T
L
Y
K
L
Y
K
-
Q
G
L
I
T
L
E
D
----------
7
PsiBlast_PDB
59.39
31%
12
- C3 -
2EWV
1
?
A:
[18-347]
-----------------------------
I
I
K
E
A
I
E
-
L
G
A
S
D
I
H
L
T
A
GAP
P
A
V
R
I
D
G
Y
I
K
F
L
K
D
F
P
R
--
L
T
P
E
D
---
T
Q
K
L
A
Y
-------------
S
V
M
S
E
K
H
R
Q
K
L
E
E
N
G
Q
V
D
F
S
F
G
V
R
-
G
V
G
R
F
R
A
N
V
-
F
Y
---
Q
R
G
S
V
A
A
A
L
R
S
----
L
P
A
-
E
I
-
P
E
F
K
--
K
L
---
G
L
P
D
--
K
----------
V
L
E
L
C
H
R
K
M
G
L
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
-
I
D
Y
I
N
Q
T
K
S
Y
H
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
-
K
S
I
----
V
N
Q
R
E
V
-----
G
---
E
D
T
K
----
S
F
A
D
A
L
R
A
A
L
R
-
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
D
I
F
P
L
N
------
Q
Q
E
-------
Q
V
R
I
V
L
S
F
I
LQ
G
I
I
S
Q
R
L
L
----
P
K
I
-
G
G
---------------------
G
R
V
L
A
Y
E
L
L
I
P
N
T
---
A
I
R
N
L
I
R
-
E
-
N
K
L
Q
Q
V
Y
S
L
M
Q
---------------------
M
Q
T
M
N
Q
T
L
Y
K
L
Y
K
-
Q
G
L
I
T
L
E
D
----------
45
HHSearch
59.01
30%
15
- C3 -
2EWV
1
?
A:
[12-357]
-----------------------
E
L
K
I
L
E
I
I
K
E
A
I
E
-
L
G
A
S
D
I
H
L
T
----
A
----
G
A
P
P
A
V
R
I
D
G
Y
I
--
K
F
L
K
D
FPR
L
T
P
E
D
T
Q
K
L
--
A
-
Y
S
V
M
S
E
K
----
H
R
Q
K
L
-
E
E
N
G
Q
V
D
F
S
F
G
-
V
R
G
V
G
R
F
R
A
N
V
-
F
Y
---
Q
R
G
S
V
A
A
A
L
R
S
----
L
P
A
E
I
P
--
E
F
K
--
K
L
---
G
L
P
D
--
K
V
----------
L
E
L
C
H
R
K
M
G
L
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
-
I
D
Y
I
N
Q
T
K
S
Y
H
I
I
T
I
E
D
P
I
E
Y
----
V
-
F
K
H
KK
S
I
V
N
Q
R
E
V
-----
G
----
E
D
T
K
---
S
F
A
D
A
L
R
A
A
L
R
-
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
D
-
I
F
P
L
NQ
Q
E
Q
V
R
I
V
-------
L
S
F
I
L
Q
G
-----
I
I
S
Q
R
L
L
P
K
I
G
G
---------------------------------------
G
R
V
L
A
Y
E
L
L
I
-
P
N
T
A
I
R
N
L
--
I
R
E
N
K
L
Q
Q
V
Y
S
L
MQ----------
M
Q
T
M
N
Q
T
L
Y
K
L
Y
K
-
Q
G
L
I
T
L
E
D
A
M
E
A
S
P
D
P
K
E
6
PsiBlast_PDB
58.97
33%
4
- C3 -
5FL3
3
?
A:
[23-282]
--------------------------------------
R
A
S
D
I
H
L
-------
Q
A
-
G
A
P
P
T
V
R
I
D
G
K
L
R
P
F
G
N
R
P
---
L
T
P
K
E
V
E
A
I
--
A
-
R
A
L
L
T
P
E
Q
L
E
E
L
E
Y
R
K
-
E
M
D
F
A
Y
T
I
P
-----
G
V
A
R
F
R
C
N
L
-
L
R
---
Q
R
G
S
F
G
L
V
M
R
V
----
V
S
E
V
-
I
-
P
S
F
E
--
A
L
---
G
L
-
P
--
R
E
--
V
------
M
E
S
L
A
A
K
E
R
G
L
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
L
-
I
D
H
I
N
L
H
Y
A
K
N
I
I
T
I
E
D
P
I
E
F
----
L
-
H
K
H
----
K
K
S
L
V
V
-----
Q
---
R
E
V
G
L
DTD
S
F
Y
T
G
L
K
Y
A
L
R
-
Q
D
P
D
V
I
M
V
G
E
M
R
D
R
E
T
V
E
A
A
L
M
A
A
Q
T
G
H
L
V
L
S
T
L
H
T
L
D
A
W
R
T
I
N
R
I
I
D
-
F
-
F
P
------
L
H
E
H
R
Q
V
R
V
L
L
A
E
S
L
L
G
-----
I
L
S
Q
R
L
L
P
K
A
----------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.18
30%
14
- C3 -
2GSZ
-
?
A:
[7-336]
-----------------------------
I
I
K
E
A
I
E
-
L
G
A
S
D
I
H
L
T
A
GA
P
P
A
V
R
I
D
G
Y
I
K
F
L
K
D
F
P
R
--
L
T
P
E
D
---
T
Q
K
------------
L
A
Y
S
V
M
S
E
K
H
R
Q
K
L
-
E
E
N
G
Q
V
D
F
S
F
G
V
R
-
G
V
G
R
F
R
A
N
V
-
F
Y
---
Q
R
G
S
V
A
A
A
L
R
S
----
L
P
A
-
E
I
-
P
E
F
K
--
K
L
---
G
L
P
D
--
K
----------
V
L
E
L
C
H
R
K
M
G
L
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
-
I
D
Y
I
N
Q
T
K
S
Y
H
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
-
K
S
I
----
V
N
Q
R
E
V
-----
G
---
E
D
T
K
----
S
F
A
D
A
L
R
A
A
L
R
-
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
D
I
F
P
L
N
------
Q
Q
E
-------
Q
V
R
I
V
L
S
F
ILQ
G
I
I
S
Q
R
L
L
----
P
K
I
-
G
G
---------------------
G
R
V
L
A
Y
E
L
L
I
P
N
T
---
A
I
R
N
L
I
R
-
E
-
N
K
L
Q
Q
V
Y
S
L
M
Q
---------------------
M
Q
T
M
N
Q
T
L
Y
K
L
Y
K
-
Q
G
L
I
T
L
E
D
----------
44
HHSearch
57.76
25%
15
- C3 -
3JVV
3
PILT_PSEAE
A:
[2-342]
-------------------------
D
I
T
E
L
L
A
F
S
A
K
-
Q
G
A
S
D
L
H
L
S
----
A
----
G
L
P
P
M
I
R
V
D
G
D
V
--
R
R
I
N
L
PP-
L
E
H
K
Q
V
H
A
L
--
I
-
Y
D
I
M
N
D
K
Q
R
K
D
F
E
E
F
L
-
E
T
D
F
S
F
E
V
--
P
---
G
V
A
R
F
R
V
N
A
-
F
N
---
Q
N
R
G
A
G
A
V
F
R
T
----
I
P
S
K
V
L
--
T
M
E
--
E
L
---
G
M
G
E
------
V
------
F
K
R
V
S
D
V
P
R
G
L
---
V
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
M
-
L
D
Y
L
N
N
T
K
Y
H
H
I
L
T
I
E
D
P
I
E
F
----
V
-
H
E
S
KKCL
V
N
Q
R
E
V
-----
H
---
R
-
D
T
L
---
G
F
S
E
A
L
R
S
A
L
R
-
E
D
P
D
I
I
L
V
G
E
M
R
D
L
E
T
I
R
L
A
L
T
A
A
E
T
G
H
L
V
F
G
T
L
H
T
T
S
A
A
K
T
I
D
R
V
V
D
-
V
F
P
A
EE
K
A
M
V
R
S
M
-------
L
S
E
S
L
Q
S
-----
V
I
S
Q
T
L
I
K
K
-------------------------------------------
R
V
A
A
H
E
I
M
I
-
G
T
P
A
I
R
N
L
--
I
R
E
D
K
VAQ
M
Y
S
A
I
Q
T
-
G
---
G
S
L
G
M
Q
T
L
D
M
C
L
K
G
--------
S
R
E
N
A
R
E
K
A
K
I
P
E
-
10
PsiBlast_PDB
57.69
34%
-25
- C3 -
2EYU
-
?
A:
[6-233]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
F
K
--
K
L
---
G
L
P
D
--
K
----------
V
L
E
L
C
H
R
K
M
G
L
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
-
I
D
Y
I
N
Q
T
K
S
Y
H
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
-
K
S
I
----
V
N
Q
R
E
V
-----
G
---
E
D
T
K
----
S
F
A
D
A
L
R
A
A
L
R
-
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
D
I
F
P
L
N
------
Q
Q
E
-------
Q
V
R
I
V
L
S
F
ILQ
G
I
I
S
Q
R
L
L
----
P
K
I
-
G
G
---------------------
G
R
V
L
A
Y
G
L
L
I
P
N
T
---
A
I
R
N
L
I
R
-
E
-
N
K
L
Q
Q
V
Y
S
L
M
Q
S
G
-----------
Q
---
A
E
T
G
M
Q
T
M
N
Q
T
L
Y
K
L
Y
K
-
Q
G
L
I
T
-------------
46
HHSearch
53.12
33%
-14
- C3 -
2EYU
-
?
A:
[7-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
K
--
K
L
---
G
L
P
D
--
K
V
L
----------
E
L
C
H
R
K
M
G
L
---
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
-
I
D
Y
I
N
Q
T
K
S
Y
H
I
I
T
I
E
D
P
I
E
Y
----
V
-
F
K
H
KK
S
I
V
N
Q
R
E
V
-----
G
----
E
D
T
K
---
S
F
A
D
A
L
R
A
A
L
R
-
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
D
-
I
F
P
L
NQ
Q
E
Q
V
R
I
V
-------
L
S
F
I
L
Q
G
-----
I
I
S
Q
R
L
L
P
K
I
G
G
---------------------------------------
G
R
V
L
A
Y
G
L
L
I
P
N
-
T
A
I
R
N
L
--
I
R
E
N
K
L
Q
Q
V
Y
S
L
M
Q
S
G
Q
---
A
E
T
G
M
Q
T
M
N
Q
T
L
Y
K
L
Y
K
-
Q
G
L
I
T
L
E
D
A
M
E
A
S
P
D
P
K
-
67
Fugue
51.39
19%
14
- C3 -
1G6O
1
?
A:
[6-328]
L
S
A
E
D
K
K
F
L
E
V
E
R
A
L
K
E
A
A
L
N
P
L
R
H
A
T
E
E
L
F
G
D
F
L
K
M
E
N
I
T
E
I
C
Y
-------
N
G
-
N
K
V
V
W
V
L
K
N
N
G
E
--
W
Q
P
F
D
---
V
R
D
R
K
A
F
S
L
S
R
L
M
H
F
A
R
C
C
A
S
F
K
K
K
T
I
D
N
-
Y
E
N
P
I
L
S
S
N
L
A
-
N
-
G
E
R
V
Q
I
V
L
S
-
P
V
---
T
V
N
D
E
T
I
S
I
S
I
R
I
P
S
K
T
T
Y
P
H
-
S
F
F
E
--
E
Q
---
G
F
Y
N
LL
D
N
K
E
Q
------
A
I
S
A
I
K
D
G
I
A
I
G
K
N
V
I
V
C
G
G
T
G
S
G
K
T
T
Y
I
K
S
I
M
E
F
I
P
K
---
E
E
R
I
I
S
I
E
D
T
E
E
I
----
V
F
K
H
H
----
K
N
Y
T
Q
L
-----
F
---
F
G
G
N
I
---
T
S
A
D
C
L
K
S
C
L
R
M
R
-
P
D
R
I
I
L
G
E
L
R
S
S
E
A
Y
D
F
Y
N
V
L
C
S
G
H
K
G
T
L
T
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
N
M
S
-------------------------------------------------------------------------------------------------------
S
S
N
S
A
-----------
A
---
R
N
I
K
F
E
S
L
I
E
G
F
K
D
L
I
D
M
I
V
H
I
N
H
H
K
Q
C
D
E
F
Y
I
K
--
47
HHSearch
48.78
25%
-12
- C3 -
4IHQ
5
?
A:
[135-398]
----------------------------------
R
D
-
P
Y
I
E
D
I
S
I
P
----
G
L
G
--
H
V
Y
I
V
H
K
V
F
G
P
M
--
R
T
S
I
K
F--
E
N
Y
E
E
L
D
N
L
--
I
-
V
S
L
S
E
K
S
Y
R
P
V
S
H
N
R
P
-
V
V
D
A
S
L
P
-----
D
----
G
S
R
V
N
F
V
Y
G
VDI
S
R
R
G
S
N
L
T
V
R
K
----
F
S
R
V
P
T
--
S
I
T
--
Q
L
I
M
F
G
T
L
S
--
S
M
M
A
A
------
Y
I
W
T
M
L
D
E
G
M
N
---
L
F
V
C
G
E
T
A
S
G
K
T
T
T
L
N
A
I
-
T
A
F
I
P
--
P
N
L
K
I
V
T
I
E
D
T
P
E
L
----
T
-
V
P
H
----
S
N
W
V
A
E
V
T
R
E
T
G
---
G
E
G
T
I
---
K
L
F
D
L
L
K
A
A
L
R
-
Q
R
P
N
Y
I
L
V
G
A
I
R
D
K
E
-
G
N
V
A
F
Q
A
M
Q
T
G
H
S
V
M
A
T
F
H
A
A
N
I
T
T
L
I
Q
R
L
T
G
-
Y
P
I
E
V-----
P
K
S
-------
Y
I
N
N
L
N
I
-----
A
L
F
Q
T
A
L
Y
D
K
----------------------------------------------------------------------------------------------------------------------