@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu30300: (2016-07-19 )
MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRYGLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRYTNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIKRRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLDEYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTGLITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKEAVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK
Atome Classification :
(20 SA)
.........10........20........--30.....--..--.40.--.....-..50---..-...---...60........70........80..--------...-------...90........100..-----...--..110.......120...---....130.......140.......150.......-160-...-.....-.170-.----.--......180--......---...190.......----200.---....-.-.210...-------------..-----..220-----...----.--------.------.-.230------------........-.240-.---.----.---....250.-...-------.--.-.260-...----.....270-------.---..-----....---.280-...-...--.290---.....--...--300---------.----....---------...--------310-..----....-----...320.......330.......340......-----.350-----.......360.-......-370........380.......390.......400.......410.......420....--...430
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
I
T
F
I
GAG
S
T
I
F
A
K
N
V
L
G
D
C
L
L
T
E
ALN--G
F
E
F
A
L
Y--DI--
D
P
K
R
--
L
Q
E
S
Q
-
L
M
L
E
---
N
L
-
R
D
R---YNP
S
V
A
INSYDD
R
K
L
A
L
QNA
G
Y
V
I
N
A
I
--------
Q
VG-------GYKP
S
T
V
I
D
F
EI
P
K
RYG
L
-----
R
Q
T
--
I
A
D
TV
G
I
G
G
I
F
R
S
L
R
T
I
P
---
V
L
F
D
I
A
K
D
M
E
E
MCPD
A
W
F
LNYTN
P
M
A
T
L
T
G
A
M
L
R
-Y---TN
I
-
K
T
I
G
L
-
C
H
S
--
V
----
Q
--
V
C
T
K
D
L
F
----
K
A
LGME---HD
G
I
E
E
R
I
A
G
I
N
H
----
M
A
W
L
---
L
E
VK-K-DGT
D
L
Y
P
-------------
E
I
-----
K
R
R
A
K
-----
E
K
Q
----K--------T------K-HH--------------
D
M
V
R
F
E
L
M
-
D
KFG-
Y
---
Y
----V---TESSEHNA-EYH-------
P
--
Y
-
F
IK--RN
Y
----
P
E
L
I
S
E
L--------Q---I
P
-----
L
D
E
Y
---
P
R
R
C
-
V
K
Q
-
I
E
N
--
W
E
K
----
M
R
D
D
I--VNN--K-N---------L----
T
H
E
R
---------
S
K
E
--------
Y
---
G
S
----
R
I
I
E
-----
A
METNE
P
F
TFGGNVLNTGLITNLPSK
A
V
V
E
V
T
-----
C
VAD-----RKKITP
C
F
A
G
E
-
L
P
E
Q
L
A
-
A
L
-NRTNIN
T
Q
L
M
T
I
E
A
AVT
R
K
K
E
A
V
Y
Q
AAMLDPHTSAE
L
S
M
K
D
I
I
S
M
C
D
D
L
F
A
AHGD--WLPEYK
32
HHSearch
85.25
27%
-30
- C4 -
3FEF
3
LPLD_BACSU
A:
[5-436]
Q
I
K
I
A
Y
I
G
G
G
S
Q
G
W
A
R
S
L
M
S
D
L
S
I
D
E
R
M
S
---
G
T
V
A
L
Y
--
D
L
--
D
F
E
A
--
A
Q
K
N
E
-
V
I
G
N
---
H
S
-
G
------
N
G
R
W
R
Y
E
A
V
S
T
L
K
K
A
L
S
A
A
D
I
V
I
I
S
I
--------
L
P
G
-------
S
L
D
D
M
E
-
V
D
V
H
L
P
E
R
C
G
I
-----
Y
Q
S
--
V
G
D
T
V
G
P
G
G
I
I
R
G
L
R
A
V
P
---
I
F
A
E
I
A
R
A
I
R
D
Y
A
P
E
S
W
V
I
N
Y
T
N
P
M
S
V
C
T
R
V
L
Y
K
-
V
F--
P
G
I
-
K
A
I
G
C
-
C
H
E
--
V
----
F
--
G
T
Q
K
L
L
A
E
M
V
T
E
R
L
G
I
E
VPR
R
E
D
I
R
V
N
V
L
G
I
N
H
----
F
T
W
I
---
T
K
A
S
-
Y
-
R
H
I
D
L
L
P
-------------
I
F
-----
R
E
F
S
A
-----
H
Y
G
----
E
S
G
Y
E
L
EGE
C
WRDSVF
C
-
S
A
--------------
H
R
V
A
F
D
L
F
-
E
T
Y
G
-
A
---
I
----
P
---
A
A
G
D
R
H
L
A
-
E
F
L
-------
P
--
G
-
P
Y
L
--
K
Q
P
------
E
V
W
K
F
H
L
T
P
I
S
F
R
K
---
Q
D
-----
R
A
E
K
---
R
Q
E
T
-
E
R
----
L
--
I
V
-------
Q
Q
R
---------
G
---------
V
----
A
E
K
A
---------
S
G
E
--------
E
---
G
V
----
N
I
I
A
-----
A
L
L
G
L
G
E
L
V
T
N
V
N
M
P
N
Q
G
Q
V
L
N
L
P
I
Q
A
I
V
E
T
N
-----
A
F
I
T
-----
R
N
R
V
Q
P
I
L
S
G
A
-
L
P
K
G
V
E
-
M
L
-
A
A
R
H
I
S
N
Q
E
A
V
A
D
A
G
L
T
K
D
T
G
L
A
F
Q
A
F
L
N
D
P
L
V
Q
I
--
D
R
S
D
A
E
Q
L
F
N
D
M
L
-------------
1
PsiBlast_PDB
83.28
27%
-13
- C4 -
3FEF
3
LPLD_BACSU
A:
[7-419]
--
K
I
A
Y
I
G
G
G
S
Q
G
W
A
R
S
L
M
S
D
L
S
I
D
E
R
M
S
--
G
-
T
V
A
L
Y
--
D
L
--
D
F
E
A
--
A
Q
K
N
E
-
V
I
G
N
H
SG
N
G
-
R
W
R
---
Y
E
---
A
V
S
T
L
---
K
K
A
L
S
A
A
D
I
V
I
I
S
I
--------
L
P
G
-------
S
L
D
D
M
E
V
-
D
V
H
L
P
E
R
C
G
I
-----
Y
Q
S
--
V
G
D
T
V
G
P
G
G
I
I
R
G
L
R
A
V
P
---
I
F
A
E
I
A
R
A
I
R
D
Y
A
P
E
S
W
V
I
N
Y
T
N
P
M
S
V
C
T
R
V
L
Y
K
V
F
---
P
G
I
-
K
A
I
G
C
-
C
H
E
--
V
F
G
T
Q
K
--
L
L
A
E
M
V
T
----
E
R
L
G
I
E
VPR
R
E
D
I
R
V
N
V
L
G
I
N
H
----
F
T
W
I
---
T
K
A
S
-
Y
-
R
H
I
D
L
L
P
-------------
I
F
-----
R
E
F
S
A
-----
H
Y
G
----
E
--------
S
------
G
-
Y
E
L
EGECWRDSVFCSA
H
R
V
A
F
D
L
F
-
E
T
Y
G
-
A
---
I
----
P
---
A
A
G
D
R
H
L
A
-
E
F
L
-------
P
--
G
P
Y
L
K
--
Q
------
P
E
V
W
K
F
H
--------
L
---
T
P
-----
I
S
F
R
---
K
Q
D
R
-
A
E
K
-
R
Q
E
--
T
E
R
----
L
---
I
--
V
Q
Q
--
R
-
G
---------
V
----
A
E
K
A
---------
S
G
E
--------
E
---
G
V
----
N
I
I
A
-----
A
L
L
G
L
G
E
L
V
T
N
V
N
M
P
N
Q
G
Q
V
L
N
L
P
I
Q
A
I
V
E
T
N
-----
A
F
I
T
-----
R
N
R
V
Q
P
I
L
S
G
A
-
L
P
K
G
V
E
-
M
L
-
A
A
R
H
I
S
N
Q
E
A
V
A
D
A
G
L
T
K
D
T
G
L
A
F
Q
A
F
L
N
D
P
--------------------------------
36
HHSearch
82.29
28%
-3
- C4 -
1S6Y
-
?
A:
[4-440]
R
L
K
I
A
T
I
G
G
G
S
S
Y
T
P
E
L
V
E
G
L
I
K
R
Y
H
E
L
P
--
V
G
E
L
W
L
V
--
D
I
--
P
E
G
K
E
K
L
E
I
V
G
-
A
L
A
K
---
R
M
-
V
E
K
---
A
G
V
P
I
E
I
H
L
T
L
D
R
R
R
A
L
D
G
A
D
F
V
T
T
Q
F
--------
R
V
G
-------
G
L
E
A
R
A
-
K
D
E
R
I
P
L
K
Y
G
V
-----
I
----
G
Q
E
T
N
G
P
G
G
L
F
K
G
L
R
T
I
P
---
V
I
L
D
I
I
R
D
M
E
E
L
C
P
D
A
W
L
I
N
F
T
N
P
A
G
M
V
T
E
A
V
L
R
-
Y
T--
K
Q
E
-
K
V
V
G
L
-
C
N
V
--
P
----
I
--
G
M
R
M
G
V
A
----
K
L
L
G
V
D
---
A
D
R
V
H
I
D
F
A
G
L
N
H
----
M
V
F
G
---
L
H
V
Y
-
L
-
D
G
V
E
V
T
E
-------------
K
V
-----
I
D
L
V
A
-----
H
P
---------------------------------------
L
G
W
E
P
D
F
L
-
K
G
L
K
-
V
---
L
----
P
---
C
--------
P
Y
H
-------
R
--
Y
-
Y
F
Q
--
T
D
K
------
M
L
A
E
E
L
E
A
A
K
T--
K
---
G
T
-----
R
A
E
V
---
V
Q
Q
L
-
E
K
E
L
F
E
L
--
Y
K
D
----
P
------------------------R---
G
G
A
Y
---------
Y
S
D
--------
A
---
A
C
----
S
L
I
S
-----
S
I
Y
N
D
K
R
D
I
Q
P
V
N
T
R
N
N
G
A
I
A
S
I
S
A
E
S
A
V
E
V
N
-----
C
V
I
T
-----
K
D
G
P
K
P
I
A
V
G
D
-
L
P
V
A
V
R
-
G
L
-
V
Q
Q
I
K
S
F
E
R
V
A
A
E
A
A
V
T
G
D
Y
Q
T
A
L
V
A
M
T
I
N
P
L
V
P
---
S
D
T
I
A
K
Q
I
L
D
E
M
L
E
A
H
K
E
--
Y
L
P
Q
F
-
4
PsiBlast_PDB
81.86
24%
-35
- C4 -
1U8X
3
GLVA_BACSU
X:
[31-463]
---
I
V
I
A
G
G
G
S
T
F
T
P
G
I
V
L
M
L
L
D
H
L
E
E
F
P
--
I
R
K
L
K
L
Y
--
D
N
--
D
K
E
R
--
Q
D
R
I
A
-
G
A
C
D
---
V
F
-
I
R
E
---
K
A
P
D
I
E
F
A
A
T
T
D
P
E
E
A
F
T
D
V
D
F
V
M
A
H
I
--------
R
V
G
-------
K
Y
A
-
M
R
A
L
D
E
Q
I
P
L
K
Y
G
V
-------
V
--
G
Q
E
T
C
G
P
G
G
I
A
Y
G
M
R
S
I
G
---
G
V
L
E
I
L
D
Y
M
E
K
Y
S
P
D
A
W
M
L
N
Y
S
N
P
A
A
I
V
A
E
A
T
R
R
-
L
R--
P
N
S
-
K
I
L
N
I
-
C
D
M
--
P
----
V
--
G
I
E
D
R
M
A
----
Q
I
L
G
L
S
S--
R
K
E
M
K
V
R
Y
Y
G
L
N
H
----
F
G
W
W
---
T
S
I
Q
D
Q
-
E
G
N
D
L
M
P
-------------
K
L
-----
K
-------------------------------------------------------
E
H
V
-
S
Q
Y
G
-
Y
---
I
----
P
K--
T
--------
S
W
N
-------
D
--
T
-
F
A
K
A-
R
D
V
QAAD
P
D
T
L
P
N
T
--------
Y
---
L
Q
-----
Y
Y
L
F
---
P
D
D
M
-
V
K
K
-
S
N
P
--
N
H
T
----
R
A
N
E
V
--
M
E
G
--
R
-
E
AFIFSQCDM
I
----
T
R
E
Q
---------
S
S
E
NSEIKIDD
H
---
A
S
----
Y
I
V
D
LARAI
A
Y
N
T
G
E
R
M
L
L
--
I
V
E
N
N
G
A
I
A
N
F
D
P
T
A
M
V
E
V
P
-----
C
I
V
G
-----
S
N
G
P
E
P
I
T
V
G
T
-
I
P
Q
F
Q
K
-
G
L
-
M
E
Q
Q
V
S
V
E
K
L
T
V
E
A
W
A
E
K
S
F
Q
K
L
W
Q
A
L
I
L
S
K
T
V
P
N
A
R
V
A
R
L
I
L
---
E
D
L
V
E
A
N
K
D
--
F
W
P
E
--
2
PsiBlast_PDB
81.23
27%
8
- C4 -
1S6Y
-
?
A:
[6-440]
--
K
I
A
T
I
G
G
G
S
S
Y
T
P
E
L
V
E
G
L
I
K
R
Y
H
E
L
P
--
V
G
E
L
W
L
V
--
D
I
PE
G
K
E
K
--
L
E
I
V
G
-
A
L
A
K
---
R
M
-
V
E
K
---
A
G
V
P
I
E
I
H
L
T
L
D
R
R
R
A
L
D
G
A
D
F
V
T
T
Q
F
--------
R
V
G
-------
G
L
E
-
A
R
A
K
D
E
R
I
P
L
K
Y
G
V
-----
I
G
Q
----
E
T
N
G
P
G
G
L
F
K
G
L
R
T
I
P
---
V
I
L
D
I
I
R
D
M
E
E
L
C
P
D
A
W
L
I
N
F
T
N
P
A
G
M
V
T
E
A
V
L
R
-
Y
---
T
K
Q
E
K
V
V
G
L
-
C
N
V
--
P
----
I
--
G
M
R
M
G
V
A
----
K
L
L
G
V
D
---
A
D
R
V
H
I
D
F
A
G
L
N
H
----
M
V
F
G
---
L
H
V
Y
-
L
-
D
G
V
-----------------
E
V
-----
T
E
K
V
I
-----
D
L
V
----
A
--------
H
------
P
----------------------------
L
G
-
W
E
P
D
F
----
L
---
K
G
L
K
V
L
P
C
-
P
Y
H
-------
R
--
Y
-
Y
F
Q
--
T
D
K
-----
M
L
A
E
E
L
--------
E
---
A
A
-----
K
T
K
G
---
T
R
A
E
-
V
---
V
Q
Q
--
L
E
K
----
E
L
F
E
L
--
Y
K
D
--
P
-------------------
R
---------
G
G
A
--------
Y
---
Y
S
D
A
A
C
S
L
I
S
-----
S
I
Y
N
D
K
R
D
I
Q
P
V
N
T
R
N
N
G
A
I
A
S
I
S
A
E
S
A
V
E
V
N
-----
C
V
I
T
-----
K
D
G
P
K
P
I
A
V
G
D
-
L
P
V
A
V
R
-
G
L
-
V
Q
Q
I
K
S
F
E
R
V
A
A
E
A
A
V
T
G
D
Y
Q
T
A
L
V
A
M
T
I
N
P
L
V
P
S
D
T
I
A
K
Q
I
L
---
D
E
M
L
E
A
H
K
E
--
Y
L
P
Q
F
-
33
HHSearch
80.35
23%
-30
- C4 -
1U8X
3
GLVA_BACSU
X:
[28-465]
S
F
S
I
V
I
A
G
G
G
S
T
F
T
P
G
I
V
L
M
L
L
D
H
L
E
E
F
P
--
I
R
K
L
K
L
Y
--
D
N
--
D
K
E
R
--
Q
D
R
I
A
-
G
A
C
D
---
V
F
-
I
R
E
---
K
A
P
D
I
E
F
A
A
T
T
D
P
E
E
A
F
T
D
V
D
F
V
M
A
H
I
--------
R
V
G
-------
K
Y
A
M
R
A
-
L
D
E
Q
I
P
L
K
Y
G
V
-----
V
----
G
Q
E
T
C
G
P
G
G
I
A
Y
G
M
R
S
I
G
---
G
V
L
E
I
L
D
Y
M
E
K
Y
S
P
D
A
W
M
L
N
Y
S
N
P
A
A
I
V
A
E
A
T
R
R
-
L
R--
P
N
S
-
K
I
L
N
I
-
C
D
M
--
P
----
V
--
G
I
E
D
R
M
A
----
Q
I
L
G
L
S
S--
R
K
E
M
K
V
R
Y
Y
G
L
N
H
----
F
G
W
W
---
T
S
I
Q
-
D
Q
E
G
N
D
L
M
P
-------------
K
L
-----
K
E
H
V
S
-----
Q
Y
G
YIP-
K
T-------
S
------
W
N
D
T
--------------
F
A
K
A
R
D
V
Q
A
A
D
P
D
-
T
---
L
----
P
---
N
--------
T
Y
L
-------
Q
--
Y
-
Y
L
F
--
P
D
D
------
M
V
K
K
S
NP------
N
---
H
T
-----
R
A
N
E
---
V
M
E
G
R
E
A
F
I
F
S
Q
--
C
D
M
----
I
T
R
E
Q
--
S
S
E
--
N
S
E
---------
I
----
K
I
D
D
---------
H
A
S
--------
Y
---
I
V
----
D
L
A
R
-----
A
I
A
Y
N
T
G
E
R
M
L
L
I
V
E
N
N
G
A
I
A
N
F
D
P
T
A
M
V
E
V
P
-----
C
I
V
G
-----
S
N
G
P
E
P
I
T
V
G
T
-
I
P
Q
F
Q
K
-
G
L
-
M
E
Q
Q
V
S
V
E
K
L
T
V
E
A
W
A
E
K
S
F
Q
K
L
W
Q
A
L
I
L
S
K
T
V
P
---
N
A
R
V
A
R
L
I
L
E
D
L
V
E
A
N
K
D
--
F
W
P
E
L
D
34
HHSearch
79.15
22%
-32
- C4 -
1UP7
3
BGLT_THEMA
A:
[2-416]
H
M
R
I
A
V
I
G
G
G
S
S
Y
T
P
E
L
V
K
G
L
L
D
I
S
E
D
V
R
--
I
D
E
V
I
F
Y
--
D
I
--
D
E
E
K
--
Q
K
I
V
V
-
D
F
V
K
---
R
L
-
V
K
------
D
R
F
K
V
L
I
S
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
Q
F
--------
R
P
G
-------
G
L
K
G
R
E
-
N
D
E
G
I
P
L
K
Y
G
L
-----
I
----
G
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
F
P
---
I
V
E
E
Y
V
D
T
V
R
K
T
-
S
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
-
Y
L--
E
Y
E
-
K
F
I
G
L
-
C
N
V
--
P
----
I
--
N
F
I
R
E
I
A
----
E
M
F
S
A
R
---
L
E
D
V
F
L
K
Y
Y
G
L
N
H
----
L
S
F
I
---
E
K
V
F
-
V
-
K
G
E
D
V
T
E
-------------
K
V
-----
F
E
N
L
K
-----
L
K
---------------------
I
-
P
D
--------------
E
D
F
P
T
W
F
Y
-
D
S
V
R
-
L
---
I
----
V
---
N
--------
P
Y
L
-------
R
--
Y
-
Y
L
M
--
E
K
K
------
M
F
K
K
I
S
T
------
H
---
E
L
-----
R
A
R
E
---
V
M
K
I
-
E
K
E
L
F
E
K
--
Y
R
T
----
A
V
--
E
--
I
P
E
----
E
---------
L
TKR-
G
G
S
M
---------
Y
S
T
--------
A
---
A
A
----
H
L
I
R
-----
D
L
E
T
D
E
G
K
I
H
I
V
N
T
R
N
N
G
S
I
E
N
L
P
D
D
Y
V
L
E
I
P
-----
C
Y
V
R
-----
S
G
R
V
H
T
L
S
Q
G
K
-
G
D
H
F
A
L
-
S
F
-
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
L
G
P
---
D
V
E
D
A
K
D
L
L
E
E
I
L
E
A
N
R
E
--
Y
V
K
L
--
8
PsiBlast_PDB
74.28
22%
26
- C4 -
1VJT
1
?
A:
[14-467]
--
K
I
S
I
I
G
A
G
S
V
R
F
A
L
Q
L
V
G
D
I
A
Q
T
E
E
L
S
--
R
E
D
T
H
I
Y
M
M
D
V
--
H
E
R
R
--
L
N
A
S
Y
-
I
L
A
R
---
K
Y
-
V
E
E
---
L
N
S
P
V
K
I
V
K
T
S
S
L
D
E
A
I
D
G
A
D
F
I
I
N
T
A
Y
P
Y
D
PRYH
D
S
G
-------
S
Q
R
W
D
E
V
T
--
K
V
G
E
K
H
G
Y
YRGID
S
Q
E
--
L
N
M
V
S
T
Y
T
Y
V
L
S
S
Y
P
D
M
K
---
L
A
L
E
I
A
E
K
M
K
K
M
A
P
K
A
Y
L
M
Q
T
A
N
P
V
F
E
I
T
Q
A
V
R
R
-
W
---
T
G
A
-
N
I
V
G
F
-
C
H
G
--
V
-------
A
G
V
Y
E
V
F
----
E
K
L
D
L
D
---
P
E
E
V
D
W
Q
V
A
G
V
N
H
----
G
I
W
L
---
N
R
F
R
-
Y
-
R
G
E
D
A
Y
P
-------------
L
L
D
E
W
I
E
K
K
L
P
E
-----
W
E
P
----
K
--------
N
------
P
-
W
D
--------------
T
Q
M
S
P
A
A
M
-
D
M
Y
K
-
F
---
Y
G
M
L
P
I
---
G
D
T
V
R
N
G
S
W
K
Y
H
YN
L
E
T
K
K
K
--
W
-
F
G
K
----
F
----
G
G
I
D
N
E
V
--------
E
---
R
P
K
----
F
H
E
Q
---
L
R
R
A
-
R
E
R
-
L
-----
I
K
----
L
A
E
E
V
--
Q
Q
N
PG
M
-
K
---------
L
----
T
E
E
H
PEIFPKGKL
S
G
E
--------
Q
---
H
I
----
P
F
I
N
-----
A
I
A
N
N
K
R
V
R
L
F
L
N
V
E
N
Q
G
T
L
K
D
F
P
D
D
V
V
M
E
L
P
V
W
V
D
C
C
G
I
H
-----
R
E
K
V
E
P
D
L
T
H
R
-
I
--
K
I
F
-
Y
L
--
W
P
R
I
L
R
M
E
W
N
L
E
A
Y
I
S
R
D
R
K
V
L
E
E
I
L
I
R
D
P
R
T
K
---
S
Y
E
Q
I
V
Q
V
L
D
E
I
F
-------------
35
HHSearch
74.16
21%
4
- C4 -
3U95
1
?
A:
[1-467]
-
M
K
I
S
I
V
G
A
G
S
V
R
F
A
L
Q
L
V
E
D
I
A
Q
T
D
E
L
S
RE
D
T
H
I
Y
L
M
--
D
V
--
H
E
R
R
--
L
N
A
S
Y
-
I
L
A
R
---
K
Y
-
V
E
E
---
L
N
S
P
V
K
V
V
K
T
E
S
L
D
E
A
I
E
G
A
D
F
I
I
N
T
A
--------
Y
P
Y
D
PRYHDS
G
S
Q
R
W
D
-
E
V
T
K
V
G
E
K
H
G
Y
-----
Y
R
G
ID
S
Q
E
L
N
M
V
S
T
Y
T
Y
V
L
S
S
Y
P
D
V
K
L
A
L
E
I
A
E
K
M
K
K
M
A
P
K
A
Y
L
M
Q
T
A
N
P
V
F
E
I
T
Q
A
V
R
R
-
W
---
T
G
A
-
N
I
I
G
F
-
C
H
G
--
V
----
A
---
G
V
Y
E
V
F
----
E
R
L
G
L
D
---
P
E
E
V
D
W
Q
V
A
G
V
N
H
----
G
I
W
L
---
N
R
F
R
-
Y
-
R
G
K
D
A
Y
P
-------------
L
L
-----
D
E
W
I
E
-----
K
E
L
SKWE
P
KNPW----
D
------
T
-
Q
M
--------------
S
P
A
A
M
D
M
Y
-
R
F
Y
G
-
M
---
L
----
P
---
I
G
D
T
-
V
R
N
-
G
T
W
-------
K
--
Y
-
H
Y
N
--
L
E
T
------
K
K
K
W
F
--------
R
RFG
G
I
DNEV
E
R
P
K
F
H
E
H
L
R
R
A
-
R
E
R
L
I
K
L
--
A
E
E
V
Q
E
N
P
H
L
K
I
TE
K
H
P
--
E
-
I
---------
F
P---
K
G
R
L
---------
S
G
E
--------
Q
---
H
I
----
P
F
I
N
-----
A
I
A
N
N
K
R
V
R
L
F
L
N
V
E
N
Q
G
A
L
K
D
F
P
D
D
L
V
M
E
L
P
-----
V
W
V
D
-----
S
S
G
I
H
R
E
K
V
E
P
D
L
T
H
R
I
K
-
I
F
Y
L
W
P
R
I
L
R
T
E
W
N
L
E
A
F
I
S
R
D
R
K
V
L
E
E
I
L
I
R
D
P
R
T
K
---
S
Y
E
Q
V
V
K
V
L
D
E
I
L
S
L
P
F
N
E
E
I
R
R
Y
Y
-
6
PsiBlast_PDB
74.14
24%
-19
- C4 -
1UP4
-
BGLT_THEMA
A:
[2-389]
--
R
I
A
V
I
G
G
G
S
S
Y
T
P
E
L
V
K
G
L
L
D
I
S
E
D
V
R
--
I
D
E
V
I
F
Y
--
D
I
--
D
E
E
K
--
Q
K
I
V
V
-
D
F
V
K
---
R
L
V
K
D
R
---
F
K
V
L
I
S
----
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
Q
F
--------
R
P
G
-------
G
L
K
G
R
E
N
-
D
E
G
I
P
L
K
Y
G
L
-------
I
--
G
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
F
P
---
I
V
E
E
Y
V
-
D
T
V
R
K
T
S
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
-
Y
---
L
E
Y
E
K
F
I
G
L
-
C
N
V
--
P
----
I
--
N
F
I
R
E
I
A
----
E
M
F
S
A
R
---
L
E
D
V
F
L
K
Y
Y
G
L
N
H
----
L
S
F
I
---
E
K
V
F
-
V
-
K
G
E
D
V
T
E
-------------
K
V
-----
F
E
N
L
K
L
KD--
E
D
F
----
P
--------
T
------
W
-
F
Y
--------------
D
S
V
R
L
I
V
N
-
P
Y
L
R
-
Y
---
Y
----
L
---
M
E
K
K
M
F
K
--------------------------------------------
K
---
I
S
-----
T
H
E
L
---
R
A
R
E
-
V
M
K
-
I
E
K
E
L
F
E
K
----
Y
R
T
A
V
--
E
I
P
--
E
-
E
---------
L
----
T
K
R
G
---------
G
S
M
--------
Y
S
T
A
A
A
----
H
L
I
R
-----
D
L
E
T
D
E
G
K
I
H
I
V
N
T
R
N
N
G
S
I
E
N
L
P
D
D
Y
V
L
E
I
P
-----
C
Y
V
R
-----
S
G
R
V
H
T
L
S
Q
G
K
-
G
D
H
F
A
L
-
S
F
-
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
--------------------------------
7
PsiBlast_PDB
73.73
24%
-3
- C4 -
1UP7
3
BGLT_THEMA
A:
[4-391]
--
R
I
A
V
I
G
G
G
S
S
Y
T
P
E
L
V
K
G
L
L
D
I
S
E
D
V
R
--
I
D
E
V
I
F
Y
--
D
I
--
D
E
E
K
--
Q
K
I
V
V
-
D
F
V
K
---
R
L
V
K
D
R
---
F
K
V
L
I
S
----
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
Q
F
--------
R
P
G
-------
G
L
K
G
R
E
N
-
D
E
G
I
P
L
K
Y
G
L
-------
I
--
G
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
F
P
---
I
V
E
E
Y
V
-
D
T
V
R
K
T
S
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
-
Y
---
L
E
Y
E
K
F
I
G
L
-
C
N
V
--
P
----
I
--
N
F
I
R
E
I
A
----
E
M
F
S
A
R
---
L
E
D
V
F
L
K
Y
Y
G
L
N
H
----
L
S
F
I
---
E
K
V
F
-
V
-
K
G
E
D
V
T
E
-------------
K
V
-----
F
E
N
L
K
L
KIPD
E
D
F
----
P
--------
T
------
W
-
F
Y
--------------
D
S
V
R
L
I
V
N
-
P
Y
L
R
-
Y
---
Y
----
L
---
M
E
K
K
M
F
K
--------------------------------------------
K
---
I
S
-----
T
H
E
L
---
R
A
R
E
-
V
M
K
-
I
E
K
E
L
F
E
K
----
Y
R
T
A
V
--
E
I
P
--
E
-
E
---------
L
----
T
K
R
G
---------
G
S
M
--------
Y
S
T
A
A
A
----
H
L
I
R
-----
D
L
E
T
D
E
G
K
I
H
I
V
N
T
R
N
N
G
S
I
E
N
L
P
D
D
Y
V
L
E
I
P
-----
C
Y
V
R
-----
S
G
R
V
H
T
L
S
Q
G
K
-
G
D
H
F
A
L
-
S
F
-
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
--------------------------------
5
PsiBlast_PDB
73.60
24%
-4
- C4 -
1UP6
6
BGLT_THEMA
A:
[3-390]
--
R
I
A
V
I
G
G
G
S
S
Y
T
P
E
L
V
K
G
L
L
D
I
S
E
D
V
R
--
I
D
E
V
I
F
Y
--
D
I
--
D
E
E
K
--
Q
K
I
V
V
-
D
F
V
K
---
R
L
V
K
D
R
---
F
K
V
L
I
S
----
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
Q
F
--------
R
P
G
-------
G
L
K
G
R
E
N
-
D
E
G
I
P
L
K
Y
G
L
-------
I
--
G
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
F
P
---
I
V
E
E
Y
V
-
D
T
V
R
K
T
S
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
-
Y
---
L
E
Y
E
K
F
I
G
L
-
C
N
V
--
P
----
I
--
N
F
I
R
E
I
A
----
E
M
F
S
A
R
---
L
E
D
V
F
L
K
Y
Y
G
L
N
H
----
L
S
F
I
---
E
K
V
F
-
V
-
K
G
E
D
V
T
E
-------------
K
V
-----
F
E
N
L
K
L
KLPD
E
D
F
----
P
--------
T
------
W
-
F
Y
--------------
D
S
V
R
L
I
V
N
-
P
Y
L
R
-
Y
---
Y
----
L
---
M
E
K
K
M
F
K
--------------------------------------------
K
---
I
S
-----
T
H
E
L
---
R
A
R
E
-
V
M
K
-
I
E
K
E
L
F
E
K
----
Y
R
T
A
V
--
E
I
P
--
E
-
E
---------
L
----
T
K
R
G
---------
G
S
M
--------
Y
S
T
A
A
A
----
H
L
I
R
-----
D
L
E
T
D
E
G
K
I
H
I
V
N
T
R
N
N
G
S
I
E
N
L
P
D
D
Y
V
L
E
I
P
-----
C
Y
V
R
-----
S
G
R
V
H
T
L
S
Q
G
K
-
G
D
H
F
A
L
-
S
F
-
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
--------------------------------
3
PsiBlast_PDB
70.75
22%
27
- C4 -
3U95
1
?
A:
[2-456]
--
K
I
S
I
V
G
A
G
S
V
R
F
A
L
Q
L
V
E
D
I
A
Q
T
D
E
L
S
--
R
E
D
T
H
I
Y
L
M
D
V
--
H
E
R
R
--
L
N
A
S
Y
-
I
L
A
R
---
K
Y
-
V
E
E
---
L
N
S
P
V
K
V
V
K
T
E
S
L
D
E
A
I
E
G
A
D
F
I
I
N
T
A
Y
P
Y
D
PRYH
D
S
G
-------
S
Q
R
W
D
E
V
T
--
K
V
G
E
K
H
G
Y
YRGID
S
Q
E
--
L
N
M
V
S
T
Y
T
Y
V
L
S
S
Y
P
D
V
K
---
L
A
L
E
I
A
E
K
M
K
K
M
A
P
K
A
Y
L
M
Q
T
A
N
P
V
F
E
I
T
Q
A
V
R
R
-
W
---
T
G
A
-
N
I
I
G
F
-
C
H
G
--
V
-------
A
G
V
Y
E
V
F
----
E
R
L
G
L
D
---
P
E
E
V
D
W
Q
V
A
G
V
N
H
----
G
I
W
L
---
N
R
F
R
-
Y
-
R
G
K
D
A
Y
P
L
L
D
E
W
I
E
KELSKW
E
P
-----
K
N
P
W
D
-----
T
Q
M
----
S
--------
P
------
A
-
A
M
--------------
D
M
Y
R
F
Y
G
M
-
L
P
I
G
-
D
---
T
----
V
RNG
T
W
K
Y
H
Y
N
L
-
E
T
K
-------
K
--
K
-
W
F
R
--
R
-
F
----
G
G
I
D
N
E
V
--------
E
---
R
P
K
----
F
H
E
H
---
L
R
R
A
-
R
E
R
-
L
-----
I
K
----
L
A
E
E
V
--
Q
E
N
--
P
-
H
---------
L
KITE
K
H
P
E
IFPKGRL--
S
G
E
--------
Q
---
H
I
----
P
F
I
N
-----
A
I
A
N
N
K
R
V
R
L
F
L
N
V
E
N
Q
G
A
L
K
D
F
P
D
D
L
V
M
E
L
P
-----
V
W
V
D
SS
G
I
H
R
E
K
V
E
P
D
L
T
H
R
-
I
--
K
I
F
-
Y
L
-
W
P
R
I
L
R
T
E
-
W
N
L
E
A
F
I
S
R
D
R
K
V
L
E
E
I
L
I
R
D
P
R
T
K
---
S
Y
E
Q
V
V
K
V
L
D
E
I
L
S
------------
48
HHSearch
54.84
15%
-56
- C4 -
1PZG
2
?
A:
[9-323]
R
K
K
V
A
M
I
G
S
G
M
I
G
G
--
T
M
G
Y
L
C
A
L
R
-
E
----
L
A
D
V
V
L
Y
--
D
V
--
V
K
G
M
--
P
E
G
K
A
-
L
D
L
S
---
H
V
-
T
S
V
---
V
D
T
N
V
S
V
R
A
E
Y
S
Y
E
A
A
L
T
G
A
D
C
V
I
V
T
A
--------
G
L
T
-------
K
V
P
G
K
P
-
D
S
E
W
--
S
R
N
D
L
----------------------
L
P
F
N
S
K
---
I
I
R
E
I
G
Q
N
I
K
K
Y
C
P
K
T
F
I
I
V
V
T
N
P
L
D
C
M
V
K
V
M
C
E
-
A
SGV
P
T
N
-
M
I
C
G
M
-
A
C
M
L
D
S
----
G
--
R
F
R
R
Y
V
A
----
D
A
L
S
V
S
---
P
R
D
V
Q
A
T
V
I
G
T
--------------------
H
G
D
C
M
V
P
-------------
L
V
-----
R
Y
I
T
V
-----
N
G
---------------------------------------------------------
Y
----
P
---
I
------
Q
-
K
F
I
-------
K
DG
V
-
V
-
T
---
E
K
------
Q
L
E
E
I
A
-------
E
---
H
----------------
T
-
K
V
S
G
G
E
I
--
V
R
--------
F
L
--
G
Q
G
----
S
--------------
A
Y
Y
A
---------
P
A
A
--------
S
---
A
V
----
A
M
A
T
-----
S
F
L
N
D
E
K
R
V
I
P
C
S
V
Y
C
N
G
E
Y
-
G
L
K
-
D
M
F
I
G
L
P
-----
A
V
I
G
-----
G
A
G
I
E
R
V
I
E
L
E
-
L
N
E
E
E
K
-
K
Q
-
F
Q
K
S
V
D
D
V
M
A
L
N
K
A
-------------------------------------------------
40
HHSearch
54.84
16%
-55
- C4 -
4AJ2
6
LDHA_RAT
A:
[19-319]
Q
N
K
I
T
V
V
G
V
G
A
V
G
M
--
A
C
A
I
S
I
L
M
K
-
D
L
---
A
D
E
L
A
L
V
--
D
V
--
I
E
D
K
--
L
K
G
E
M
-
M
D
L
Q
---
H
G
-
S
L
F
---
L
K
T
-
P
K
I
V
-
S
S
K
D
Y
S
V
T
A
N
S
K
L
V
I
I
T
A
--------
G
A
R
-------
Q
Q
E
G
E
S
-
R
L
N
-------
L
----------------------
V
Q
R
N
V
N
---
I
F
K
F
I
I
P
N
V
V
K
Y
S
P
Q
C
K
L
L
I
V
S
N
P
V
D
I
L
T
Y
V
A
W
K
-
I
S
GF
P
K
N
-
R
V
I
G
S
G
C
N
L
D
-
S
----
A
--
R
F
R
Y
L
M
G
----
E
R
L
G
V
H
---
P
L
S
C
H
G
W
V
L
G
-
E
H
GDSS
V
P
V
W
---
S
G
V
N
-
V
-
A
G
V
S
L
K
S
-------------
L
N
-----
P
Q
------------------------------------------------------------
L
G
T
D
---
A
----
D
---
K
--------
E
Q
W
-------
K
-----------
D
------
V
H
K
Q
---------
V
---
V
D
-----
S
A
--------------
Y
E
V
--
I
K
--------
L
----
K
G
--
Y
-
T
---------------
S
W
A
---------
I
G
L
--------
S
---
V
A
----
D
L
A
E
-----
S
I
M
K
N
L
R
R
V
H
P
I
S
T
M
I
K
G
L
-
Y
G
I
K
E
D
V
F
L
S
V
P
-----
C
I
L
G
-----
Q
N
G
I
S
D
V
V
K
V
T
-
L
T
P
D
E
E
-
A
R
-
L
K
K
S
A
----------------------------------------------------------
45
HHSearch
52.51
18%
-48
- C4 -
1A5Z
7
LDH_THEMA
A:
[1-311]
-
M
K
I
G
I
V
G
L
G
R
V
G
--
S
S
T
A
F
A
L
L
M
K
-
G
F
---
A
R
E
M
V
L
I
--
D
V
--
D
K
K
R
--
A
E
G
D
----
A
L
---
D
L
-
I
H
G
---
T
P
F
T
R
R
A
N
I
Y
A
G
D
Y
A
D
L
K
G
S
D
V
V
I
V
A
A
--------
G
V
P
-------
Q
K
P
G
E
T
--------
R
----------------------
L
Q
L
L
G
R
N
A
R
---
V
M
K
E
I
A
R
N
V
S
K
Y
A
P
D
S
I
V
I
V
V
T
N
P
V
D
V
L
T
Y
F
F
L
K
-
E
S
GM
D
P
R
-
K
V
F
G
S
-
G
T
V
--
L
D
T
--
A
--
R
L
R
T
L
I
A
----
Q
H
C
G
F
S
---
P
R
S
V
H
V
Y
V
I
G
E
--------------------
H
G
D
S
E
V
P
-------------
V
W
-----
S
G
A
M
----------------------------------------------------------
I
G
-
G
---
I
----
P
---
L
------
Q
-
N
M
C
-------
Q
--
V
-
C
Q
K
--
C
D
S
-----
K
I
L
E
N
F
--------
A
----
E
--------------
K
T
-
K
R
A
A
Y
E
I
--
I
E
--------
R
----
K
G
----
A
--------------
T
H
Y
A
---------
I
A
L
--------
A
---
V
A
----
D
I
V
E
-----
S
I
F
F
D
E
K
R
V
L
T
L
S
V
Y
L
E
D
Y
L
-
G
-
V
K
D
L
C
I
S
V
P
-----
V
T
L
G
-----
K
H
G
V
E
R
I
L
E
L
N
-
L
N
E
E
E
L
-
E
A
-
F
R
K
S
A
S
I
L
K
N
A
I
N
E
I
T
A
E
E
--------------------------------------------
47
HHSearch
50.75
12%
-44
- C4 -
4ND2
4
?
A:
[4-301]
R
R
K
I
A
V
I
G
S
G
Q
I
G
G
--
N
I
A
Y
I
V
G
K
D
-
N
----
L
A
D
V
V
L
F
--
D
I
--
A
E
G
I
--
P
Q
G
K
A
----
L
---
D
I
-
T
H
S
M
VM
F
G
S
T
S
K
V
I
G
T
N
D
Y
-
A
D
I
S
G
S
D
V
V
I
I
T
A
--------
S
I
P
-------
G
R
P
K
D
D
-
R
S
E
L
-----------------------------
L
F
G
N
A
R
---
I
L
D
S
V
A
E
G
V
K
K
Y
C
P
N
A
F
V
I
C
I
T
N
P
L
D
V
M
V
S
H
F
Q
K
-
V
S
GL
P
H
N
-
K
V
C
G
M
-
A
G
V
--
L
D
S
--
S
--
R
F
R
T
F
I
A
----
Q
H
F
G
V
N
---
A
S
D
V
S
A
N
V
I
G
G
--------------------
H
G
D
G
M
V
P
-------------
A
T
-----
S
S
V
S
V
-----
G
G
---------------------------------------------------------
V
----
P
---
L
------
S
-
S
F
I
-------
K
Q
G
L
-
I
T
Q
E
Q
I
D
E
------
I
V
C
H
------------------------------
T
-
R
I
A
W
K
E
V
--
A
D
--------
N
L
--
K
T
G
--
T
-
A
---------------
Y
F
A
---------
P
A
A
--------
A
---
A
V
----
K
M
A
E
-----
A
Y
L
K
D
K
K
A
V
V
P
C
S
A
F
C
S
N
H
-
Y
G
V
K
-
G
I
Y
M
G
V
P
-----
T
I
I
G
-----
K
N
G
V
E
D
I
L
E
L
D
-
L
T
P
L
E
Q
-
K
L
-
L
G
E
------------------------------------------------------------
46
HHSearch
49.92
17%
-17
- C4 -
3PQE
-
LDH_BACSU
A:
[5-315]
V
N
K
V
A
L
I
G
A
G
F
V
G
--
S
S
Y
A
F
A
L
I
N
Q
-
G
I
---
T
D
E
L
V
V
I
--
D
V
--
N
K
E
K
--
A
M
G
D
V
M
D
L
N
H
---
G
K
--
A
F
---
A
P
Q
P
V
K
T
S
-
Y
G
T
Y
-
E
D
C
K
D
A
D
I
V
C
I
C
A
--------
G
A
N
-------
Q
K
P
G
E
T
-
R
L
-------
E
L
----------------------
V
E
K
N
L
K
---
I
F
K
G
I
V
S
E
V
M
A
S
G
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
-
F
S
GL
P
K
E
-
R
V
I
G
S
G
T
T
L
D
-
S
----
A
--
R
F
R
F
M
L
S
----
E
Y
F
G
A
A
---
P
Q
N
V
C
A
H
I
I
G
-
E
H
-------------------
G
D
T
E
L
P
-------------
V
W
-----
S
H
A
N
V
-----
G
G
---------------------------------------
V
P
V
-
S
E
L
V
-
E
K
N
D
------------------------------------
A
-
Y
-
K
--
Q
-
E
------
E
L
D
Q
I
--------
V
----
D
--------------
D
V
-
K
N
A
A
Y
H
I
--
I
E
--------
K
----
K
G
----
A
--------------
T
Y
Y
G
---------
V
A
M
--------
S
---
L
A
----
R
I
T
K
-----
A
I
L
H
N
E
N
S
I
L
T
V
S
T
Y
L
D
G
Q
Y
-
G
-
A
D
D
V
Y
I
G
V
P
-----
A
V
V
N
-----
R
G
G
I
A
G
I
T
E
L
N
-
L
N
E
K
E
K
E
Q
F
-
L
H
S
A
G
V
L
K
N
I
L
K
P
H
F
A
-----------------------------------------------
49
HHSearch
49.39
16%
-66
- C4 -
3VPG
-
LDH_THECA
A:
[1-297]
-
M
K
V
G
I
V
G
S
G
M
V
G
--
S
A
T
A
Y
A
L
A
L
L
-
G
V
---
A
R
E
V
V
L
V
--
D
L
--
D
R
K
L
--
A
Q
A
----
H
A
E
---
D
I
-
L
H
A
---
T
P
F
A
H
P
V
W
V
R
A
G
S
Y
G
D
L
E
G
A
R
A
V
V
L
A
A
--------
G
V
A
-------
Q
R
P
G
E
T
-
R
L
Q
-------
L
----------------------
L
D
R
N
A
Q
---
V
F
A
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
-
L
S
AL
P
P
G
-
R
V
V
G
S
G
T
I
L
D
-
T
----
A
--
R
F
R
A
L
L
A
----
E
H
L
R
V
A
---
P
Q
S
V
H
A
Y
V
L
G
E
H
G
----
D
S
E
V
LVW
S
S
A
Q
-
V
-
G
G
V
P
L
L
E
-------------
F
A
-----
E
A
R
-----------------------------------------------------------
G
R
-
A
---
L
----
S
---
P
--------
E
D
R
-------
A
-----------
R
------
I
D
E
G
---------
V
---
R
R
-----
A
A
Y
--------------
R
I
--
I
E
------------
G
K
G
----
A
--------------
T
Y
Y
G
---------
I
G
A
--------
G
---
L
A
----
R
L
V
R
-----
A
I
L
T
D
E
K
G
V
Y
T
V
S
A
F
T
P
E
-
V
E
G
V
L
-
E
V
S
L
S
L
P
-----
R
I
L
G
-----
A
G
G
V
E
G
T
V
Y
P
S
-
L
S
P
E
E
R
-
E
A
-
L
R
R
S
-----------------------------------------------------------
41
HHSearch
48.85
16%
-58
- C4 -
4ROR
2
MDH_METEP
A:
[3-320]
R
S
K
I
A
L
I
G
A
G
Q
I
G
--
G
T
L
A
H
L
A
G
L
K
-
E
L
----
G
D
V
V
L
F
--
D
I
--
V
D
G
V
--
P
Q
G
K
A
-
L
D
I
A
---
E
S
-
A
P
V
---
D
G
F
D
A
K
Y
S
G
A
S
D
Y
-
S
A
I
A
G
A
D
V
V
I
V
T
A
--------
G
V
P
-------
R
K
P
G
M
S
-
R
D
D
L
-----------------------------
I
G
I
N
L
K
---
V
M
E
A
V
G
A
G
I
K
E
H
A
P
D
A
F
V
I
C
I
T
N
P
L
D
A
M
V
W
A
L
Q
K
-
F
S
GL
P
T
N
-
K
V
V
G
M
-
A
G
V
--
L
----
D
S
A
R
F
R
H
F
L
A
----
E
E
F
G
V
S
---
V
E
D
V
T
A
F
V
L
G
G
--------------------
H
G
D
D
M
V
P
-------------
L
T
-----
R
Y
S
T
V
-----
A
G
---------------------------------------------------------
V
----
P
---
L
------
T
-
D
L
V
-------
K
--
L
-
G
W
T
--
T
Q
E
------
K
L
D
A
M
--------
V
----
E
--------------
R
T
-
R
K
G
G
G
E
I
--
V
N
--------
L
L
--
K
T
G
--
S
-
A
---------------
F
Y
A
---------
P
A
A
--------
S
---
A
I
----
A
M
A
E
-----
S
Y
L
R
D
K
K
R
V
L
P
C
A
A
Y
L
D
G
Q
Y
-
G
-
I
D
G
L
Y
V
G
V
P
-----
V
V
I
G
-----
E
N
G
V
E
R
V
L
E
V
T
-
F
N
D
D
E
K
-
A
M
-
F
E
K
S
V
N
S
V
K
G
L
I
E
A
C
K
S
V
N
D
K
L
A
----------------------------------------