@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu35960: (2016-07-30 )
MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSVSTLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPTDSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGAKVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDIQAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGKLATEAADDILHGKKVQKTISAPLKLETQK
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.....---..-130-........140..----.....150....------.-.--.160.......170.......180-------...-..--.-.--.--.190....-...200.......210...---....220.......230.......----240---.--.......250.......260.-.......270.......280......--.290..-......300...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKK
A
V
S
V
I
L
T
L
S
L
F
L
L
T
ACSLEPPQWAKPSNSGN
K
K
E
F
T
I
G
L
S
V
STLNN
P
F
F
V
S
L
K
K
G
I
E
K
E
A
K
KRG
M
K
V
I
I
V
DAQNDSSKQT
S
D
V
E
D
L
I
Q
QGV
D
A
L
L
INPTD
S
S
A
I
S
T
A
V
ESANAVG
V
P
V
V
T
IDRS---AE-Q-G-
K
V
E
T
L
V
ASDNVKG----
G
E
M
A
A
A
F
I
A
D
K
L------G-K--G
A
K
V
A
E
LEGVPGASA
T
R
ERGSG---------FH
N
-
I
A
--
D
-
Q
--
K
--
L
Q
V
V
TKQS-ADFDRTK
G
L
T
V
M
E
N
L
L
QGH---PD
I
Q
A
V
FAHND
E
M
A
L
G
A
L
E
A
INSS----G-
K
---
D
--
I
L
V
I
G
FDGN
K
D
A
L
A
S
I
KD-RK-L
S
A
T
V
AQ
Q
P
E
L
I
G
K
L
A
T
E
A
A
D
D
I
LH
G
--
K
K
-
V
Q
K
-
T
ISA
P
L
K
L
ETQK
3
PsiBlast_PDB
86.80
54%
-12
- C1 -
1URP
-
RBSB_ECOLI
A:
[3-267]
--------------------------------------
T
I
A
L
V
V
S
T
L
N
N
P
F
F
V
S
L
K
D
G
A
Q
K
E
A
D
K
L
G
Y
N
L
V
V
L
D
S
Q
N
N
P
A
K
E
L
A
N
V
Q
D
L
T
V
R
G
T
K
I
L
L
I
N
P
T
D
S
D
A
V
G
N
A
V
K
M
A
N
Q
A
N
I
P
V
I
T
L
D
R
Q
---
A
T
-
K
-
G
-
E
V
V
S
H
I
A
S
D
N
V
L
G
----
G
K
I
A
G
D
Y
I
A
K
K
A
------
G
-
E
--
G
A
K
V
I
E
L
Q
G
I
A
G
T
S
A
A
R
E
R
G
E
G
---------
F
Q
Q
A
V
A
--
A
-
H
--
K
--
F
N
V
L
A
S
Q
P
-
A
D
F
D
R
I
K
G
L
N
V
M
Q
N
L
L
T
A
H
---
P
D
V
Q
A
V
F
A
Q
N
D
E
M
A
L
G
A
L
R
A
L
Q
T
A
----
G
-
K
S--
D
--
V
M
V
V
G
F
D
G
T
P
D
G
E
K
A
V
N
D
-
G
K
-
L
A
A
T
I
A
Q
L
P
D
Q
I
G
A
K
G
V
E
T
A
D
K
V
L
K
G
--
E
K
-
V
Q
A
-
K
Y
P
V
D
L
K
L
----
5
PsiBlast_PDB
86.55
54%
-7
- C1 -
2GX6
1
RBSB_ECOLI
A:
[4-268]
--------------------------------------
T
I
A
L
V
V
S
T
L
N
N
P
F
F
V
S
L
K
D
G
A
Q
K
E
A
D
K
L
G
Y
N
L
V
V
L
D
S
Q
N
N
P
A
K
E
L
A
N
V
Q
D
L
T
V
R
G
V
K
I
L
L
I
N
P
V
D
S
D
A
V
G
N
A
V
K
M
A
N
Q
A
N
I
P
V
I
T
L
D
R
Q
---
A
T
-
K
-
G
-
E
V
V
S
H
I
A
S
D
N
V
L
G
----
G
K
I
A
G
D
Y
I
A
K
K
A
------
G
-
E
--
G
A
K
V
I
E
L
Q
G
I
A
G
T
S
A
A
R
E
R
G
E
G
---------
F
Q
Q
A
V
A
--
A
-
H
--
K
--
F
N
V
L
A
S
Q
P
-
A
D
F
D
R
I
K
G
L
N
V
M
Q
N
L
L
T
A
H
---
P
D
V
Q
A
V
F
A
Q
N
D
E
M
A
L
G
A
L
R
A
L
Q
T
A
----
G
-
K
S--
D
--
V
M
V
V
G
F
D
G
T
P
D
G
E
K
A
V
N
D
-
G
K
-
L
A
A
T
I
A
Q
L
P
D
Q
I
G
A
K
G
V
E
V
A
D
K
V
L
K
G
--
E
K
-
V
Q
A
-
K
Y
P
V
D
L
K
L
----
2
PsiBlast_PDB
86.27
56%
-0
- C1 -
4ZJP
2
?
A:
[26-292]
--------------------------------------
T
I
A
L
T
V
S
T
L
D
N
P
F
F
V
S
L
K
D
G
A
Q
K
K
A
T
E
L
G
Y
K
L
V
V
L
D
S
Q
N
D
P
S
K
E
L
S
N
V
E
D
L
T
V
R
G
A
K
V
L
L
I
N
P
T
D
S
A
A
V
S
N
A
V
A
I
A
N
R
N
K
I
P
V
I
T
L
D
R
G
---
A
A
-
K
-
G
-
E
V
V
S
H
I
A
S
D
N
V
A
G
----
G
K
M
A
G
D
F
I
A
Q
K
L
------
G
-
D
--
G
A
K
V
I
Q
L
E
G
L
A
G
T
S
A
A
R
E
R
G
E
G
---------
F
K
Q
A
I
E
--
A
-
H
--
K
--
F
D
V
L
A
S
Q
P
-
A
D
F
D
R
T
K
G
L
N
V
T
E
N
L
L
A
S
K
---
G
S
V
Q
A
I
F
A
Q
N
D
E
M
A
L
G
A
L
R
A
I
S
A
A
----
G
-
K
---
K
--
V
L
V
V
G
F
D
G
T
E
D
G
V
K
A
V
K
S
-
G
K
-
L
A
A
T
V
A
Q
Q
P
E
L
I
G
S
L
G
V
E
T
A
D
K
I
L
K
G
--
E
K
-
V
D
A
-
K
I
P
V
A
L
K
V
V
T
E
-
4
PsiBlast_PDB
83.49
54%
1
- C1 -
2DRI
1
RBSB_ECOLI
A:
[3-267]
--------------------------------------
T
I
A
L
V
V
S
T
L
N
N
P
F
F
V
S
L
K
D
G
A
Q
K
E
A
D
K
L
G
Y
N
L
V
V
L
D
S
Q
N
N
P
A
K
E
L
A
N
V
Q
D
L
T
V
R
G
T
K
I
L
L
I
N
P
T
D
S
D
A
V
G
N
A
V
K
M
A
N
Q
A
N
I
P
V
I
T
L
D
R
Q
---
A
T
-
K
-
G
-
E
V
V
S
H
I
A
S
D
N
V
L
G
----
G
K
I
A
G
D
Y
I
A
K
K
A
------
G
-
E
--
G
A
K
V
I
E
L
Q
G
I
A
G
T
S
A
A
R
E
R
G
E
G
---------
F
Q
Q
A
V
A
--
A
-
H
--
K
--
F
N
V
L
A
S
Q
P
-
A
D
F
D
R
I
K
G
L
N
V
M
Q
N
L
L
T
A
H
---
P
D
V
Q
A
V
F
A
Q
N
D
E
M
A
L
G
A
L
R
A
L
Q
T
A
----
G
-
K
S--
D
--
V
M
V
V
G
F
D
G
T
P
D
G
E
K
A
V
N
D
-
G
K
-
L
A
A
T
I
A
Q
L
P
D
Q
I
G
A
K
G
V
E
T
A
D
K
V
L
K
G
--
E
K
-
V
Q
A
-
K
Y
P
V
D
L
K
L
----
6
PsiBlast_PDB
83.37
54%
-4
- C1 -
1DBP
1
RBSB_ECOLI
A:
[3-267]
--------------------------------------
T
I
A
L
V
V
S
T
L
N
N
P
F
F
V
S
L
K
D
G
A
Q
K
E
A
D
K
L
G
Y
N
L
V
V
L
D
S
Q
N
N
P
A
K
E
L
A
N
V
Q
D
L
T
V
R
G
T
K
I
L
L
I
N
P
T
D
S
D
A
V
D
N
A
V
K
M
A
N
Q
A
N
I
P
V
I
T
L
D
R
Q
---
A
T
-
K
-
G
-
E
V
V
S
H
I
A
S
D
N
V
L
G
----
G
K
I
A
G
D
Y
I
A
K
K
A
------
G
-
E
--
G
A
K
V
I
E
L
Q
G
I
A
G
T
S
A
A
R
E
R
G
E
G
---------
F
Q
Q
A
V
A
--
A
-
H
--
K
--
F
N
V
L
A
S
Q
P
-
A
D
F
D
R
I
K
G
L
N
V
M
Q
N
L
L
T
A
H
---
P
D
V
Q
A
V
F
A
Q
N
D
E
M
A
L
G
A
L
R
A
L
Q
T
A
----
G
-
K
S--
D
--
V
M
V
V
G
F
D
G
T
P
D
G
E
K
A
V
N
D
-
G
K
-
L
A
A
T
I
A
Q
L
P
D
Q
I
G
A
K
G
V
E
T
A
D
K
V
L
K
G
--
E
K
-
V
Q
A
-
K
Y
P
V
D
L
K
L
----
51
HHSearch
83.02
59%
9
* C1 *
2IOY
1
?
A:
[2-271]
-------------------------------------
K
T
I
G
L
V
I
S
T
L
N
N
P
F
F
V
T
L
K
N
G
A
E
E
K
A
K
E
L
G
Y
K
I
I
V
E
D
S
Q
N
D
S
S
K
E
L
S
N
V
E
D
L
I
Q
Q
K
V
D
V
L
L
I
N
P
V
D
S
D
A
V
V
T
A
I
K
E
A
N
S
K
N
I
P
V
I
T
I
D
R
S
---
A
--
N
-
G
G
D
V
V
C
H
I
A
S
D
N
V
K
G
----
G
E
M
A
A
E
F
I
A
K
A
L
------
K
-
G
--
K
G
N
V
V
E
L
E
G
I
P
G
A
S
A
A
R
D
R
G
K
G
---------
F
D
E
-
A
I
A
-
K
Y
P
--
D
--
I
K
I
V
A
K
Q
A
-
A
D
F
D
R
S
K
G
L
S
V
M
E
N
I
L
Q
A
Q
---
P
K
I
D
A
V
F
A
Q
N
D
E
M
A
L
G
A
I
K
A
I
E
A
A
----
N
-
R
Q--
G
--
I
I
V
V
G
F
D
G
T
E
D
A
L
K
A
I
K
E
-
G
K
-
M
A
A
T
I
A
Q
Q
P
A
L
M
G
S
L
G
V
E
M
A
D
K
Y
L
K
G
--
E
K
-
I
P
N
-
F
I
P
A
E
L
K
L
I
T
K
-
9
PsiBlast_PDB
82.60
53%
3
- C1 -
1DRK
1
RBSB_ECOLI
A:
[3-267]
--------------------------------------
T
I
A
L
V
V
S
T
L
N
N
P
F
F
V
S
L
K
D
G
A
Q
K
E
A
D
K
L
G
Y
N
L
V
V
L
D
S
Q
N
N
P
A
K
E
L
A
N
V
Q
D
L
T
V
R
G
T
K
I
L
L
I
N
P
T
D
S
D
A
V
G
N
A
V
K
M
A
N
Q
A
N
I
P
V
I
T
L
D
R
Q
---
A
T
-
K
-
G
-
E
V
V
S
H
I
A
S
D
N
V
L
G
----
G
K
I
A
G
D
Y
I
A
K
K
A
------
G
-
E
--
G
A
K
V
I
E
L
Q
G
T
A
A
T
S
A
A
R
E
R
G
E
G
---------
F
Q
Q
A
V
A
--
A
-
H
--
K
--
F
N
V
L
A
S
Q
P
-
A
D
F
D
R
I
K
G
L
N
V
M
Q
N
L
L
T
A
H
---
P
D
V
Q
A
V
F
A
Q
N
D
E
M
A
L
G
A
L
R
A
L
Q
T
A
----
G
-
K
S--
D
--
V
M
V
V
G
F
D
G
T
P
D
G
E
K
A
V
N
D
-
G
K
-
L
A
A
T
I
A
Q
L
P
D
Q
I
G
A
K
G
V
E
T
A
D
K
V
L
K
G
--
E
K
-
V
Q
A
-
K
Y
P
V
D
L
K
L
----
8
PsiBlast_PDB
82.60
53%
1
- C1 -
1DRJ
1
RBSB_ECOLI
A:
[3-267]
--------------------------------------
T
I
A
L
V
V
S
T
L
N
N
P
F
F
V
S
L
K
D
G
A
Q
K
E
A
D
K
L
G
Y
N
L
V
V
L
D
S
Q
N
N
P
A
K
E
L
A
N
V
Q
D
L
T
V
R
G
T
K
I
L
L
I
N
P
T
D
S
D
A
V
G
N
A
V
K
M
A
N
Q
A
N
I
P
V
I
T
L
D
R
Q
---
A
T
-
K
-
G
-
E
V
V
S
H
I
A
S
D
N
V
L
G
----
G
K
I
A
G
D
Y
I
A
K
K
A
------
G
-
E
--
G
A
K
V
I
E
L
Q
G
I
A
R
T
S
A
A
R
E
R
G
E
G
---------
F
Q
Q
A
V
A
--
A
-
H
--
K
--
F
N
V
L
A
S
Q
P
-
A
D
F
D
R
I
K
G
L
N
V
M
Q
N
L
L
T
A
H
---
P
D
V
Q
A
V
F
A
Q
N
D
E
M
A
L
G
A
L
R
A
L
Q
T
A
----
G
-
K
S--
D
--
V
M
V
V
G
F
D
G
T
P
D
G
E
K
A
V
N
D
-
G
K
-
L
A
A
T
I
A
Q
L
P
D
Q
I
G
A
K
G
V
E
T
A
D
K
V
L
K
G
--
E
K
-
V
Q
A
-
K
Y
P
V
D
L
K
L
----
21
PsiBlast_CBE
82.35
59%
8
- C1 -
2IOY
1
?
B:
[3-272]
--------------------------------------
T
I
G
L
V
I
S
T
L
N
N
P
F
F
V
T
L
K
N
G
A
E
E
K
A
K
E
L
G
Y
K
I
I
V
E
D
S
Q
N
D
S
S
K
E
L
S
N
V
E
D
L
I
Q
Q
K
V
D
V
L
L
I
N
P
V
D
S
D
A
V
V
T
A
I
K
E
A
N
S
K
N
I
P
V
I
T
I
D
R
S
---
A
N
-
G
-
G
-
D
V
V
C
H
I
A
S
D
N
V
K
G
----
G
E
M
A
A
E
F
I
A
K
A
L
------
K
-
G
--
K
G
N
V
V
E
L
E
G
I
P
G
A
S
A
A
R
D
R
G
K
G
---------
F
D
E
A
I
A
--
K
-
Y
P-
D
--
I
K
I
V
A
K
Q
A
-
A
D
F
D
R
S
K
G
L
S
V
M
E
N
I
L
Q
A
Q
---
P
K
I
D
A
V
F
A
Q
N
D
E
M
A
L
G
A
I
K
A
I
E
A
A
----
N
-
R
---
Q
G-
I
I
V
V
G
F
D
G
T
E
D
A
L
K
A
I
K
E
-
G
K
-
M
A
A
T
I
A
Q
Q
P
A
L
M
G
S
L
G
V
E
M
A
D
K
Y
L
K
G
--
E
K
-
I
P
N
-
F
I
P
A
E
L
K
L
I
T
K
E
1
PsiBlast_PDB
82.31
59%
5
- C1 -
2IOY
1
?
A:
[3-272]
--------------------------------------
T
I
G
L
V
I
S
T
L
N
N
P
F
F
V
T
L
K
N
G
A
E
E
K
A
K
E
L
G
Y
K
I
I
V
E
D
S
Q
N
D
S
S
K
E
L
S
N
V
E
D
L
I
Q
Q
K
V
D
V
L
L
I
N
P
V
D
S
D
A
V
V
T
A
I
K
E
A
N
S
K
N
I
P
V
I
T
I
D
R
S
---
A
N
-
G
-
G
-
D
V
V
C
H
I
A
S
D
N
V
K
G
----
G
E
M
A
A
E
F
I
A
K
A
L
------
K
-
G
--
K
G
N
V
V
E
L
E
G
I
P
G
A
S
A
A
R
D
R
G
K
G
---------
F
D
E
A
I
A
--
K
-
Y
P-
D
--
I
K
I
V
A
K
Q
A
-
A
D
F
D
R
S
K
G
L
S
V
M
E
N
I
L
Q
A
Q
---
P
K
I
D
A
V
F
A
Q
N
D
E
M
A
L
G
A
I
K
A
I
E
A
A
----
N
-
R
---
Q
G-
I
I
V
V
G
F
D
G
T
E
D
A
L
K
A
I
K
E
-
G
K
-
M
A
A
T
I
A
Q
Q
P
A
L
M
G
S
L
G
V
E
M
A
D
K
Y
L
K
G
--
E
K
-
I
P
N
-
F
I
P
A
E
L
K
L
I
T
K
E
35
HHSearch
81.78
53%
21
- C1 -
2DRI
1
RBSB_ECOLI
A:
[2-271]
-------------------------------------
D
T
I
A
L
V
V
S
T
L
N
N
P
F
F
V
S
L
K
D
G
A
Q
K
E
A
D
K
L
G
Y
N
L
V
V
L
D
S
Q
N
N
P
A
K
E
L
A
N
V
Q
D
L
T
V
R
G
T
K
I
L
L
I
N
P
T
D
S
D
A
V
G
N
A
V
K
M
A
N
Q
A
N
I
P
V
I
T
L
D
R
Q
---
A
--
T
-
K
G
E
V
V
S
H
I
A
S
D
N
V
L
G
----
G
K
I
A
G
D
Y
I
A
K
K
A
------
G
-
E
--
G
A
K
V
I
E
L
Q
G
I
A
G
T
S
A
A
R
E
R
G
E
G
---------
F
Q
Q
-
A
V
A
-
A
-
H
--
K
--
F
N
V
L
A
S
Q
P
-
A
D
F
D
R
I
K
G
L
N
V
M
Q
N
L
L
T
A
H
---
P
D
V
Q
A
V
F
A
Q
N
D
E
M
A
L
G
A
L
R
A
L
Q
T
A
----
G
-
K
S--
D
--
V
M
V
V
G
F
D
G
T
P
D
G
E
K
A
V
N
D
-
G
K
-
L
A
A
T
I
A
Q
L
P
D
Q
I
G
A
K
G
V
E
T
A
D
K
V
L
K
G
--
E
K
-
V
Q
A
-
K
Y
P
V
D
L
K
L
V
V
K
Q
7
PsiBlast_PDB
80.41
53%
-10
- C1 -
1BA2
-
RBSB_ECOLI
A:
[3-267]
--------------------------------------
T
I
A
L
V
V
S
T
L
N
N
P
F
F
V
S
L
K
D
G
A
Q
K
E
A
D
K
L
G
Y
N
L
V
V
L
D
S
Q
N
N
P
A
K
E
L
A
N
V
Q
D
L
T
V
R
G
T
K
I
L
L
I
N
P
T
R
S
D
A
V
G
N
A
V
K
M
A
N
Q
A
N
I
P
V
I
T
L
D
R
Q
---
A
T
-
K
-
G
-
E
V
V
S
H
I
A
S
D
N
V
L
G
----
G
K
I
A
G
D
Y
I
A
K
K
A
------
G
-
E
--
G
A
K
V
I
E
L
Q
G
I
A
G
T
S
A
A
R
E
R
G
E
G
---------
F
Q
Q
A
V
A
--
A
-
H
--
K
--
F
N
V
L
A
S
Q
P
-
A
D
F
D
R
I
K
G
L
N
V
M
Q
N
L
L
T
A
H
---
P
D
V
Q
A
V
F
A
Q
N
D
E
M
A
L
G
A
L
R
A
L
Q
T
A
----
G
-
K
S--
D
--
V
M
V
V
G
F
D
G
T
P
D
G
E
K
A
V
N
D
-
G
K
-
L
A
A
T
I
A
Q
L
P
D
Q
I
G
A
K
G
V
E
T
A
D
K
V
L
K
G
--
E
K
-
V
Q
A
-
K
Y
P
V
D
L
K
L
----
40
HHSearch
77.68
27%
-14
- C1 -
3L6U
1
?
A:
[9-282]
-------------------------------------
N
I
V
G
F
T
I
V
N
D
K
H
E
F
A
Q
R
L
I
N
A
F
K
A
E
A
K
A
N
K
Y
E
A
L
V
A
T
S
Q
N
S
R
I
S
E
R
E
Q
I
L
E
F
V
H
L
K
V
D
A
I
F
I
T
T
L
D
D
V
Y
I
G
S
A
I
E
E
A
K
K
A
G
I
P
V
F
A
I
D
R
M
---
I
--
R
-
S
D
A
V
V
S
S
I
T
S
N
N
Q
M
I
----
G
E
Q
L
A
S
Y
I
K
N
E
L
I
K
Q
---
T
-
G
RS
T
G
R
I
V
E
I
T
G
T
A
N
V
Y
T
T
N
E
R
H
R
G
---------
F
L
K
-
G
I
E
-
N
E
P
--
T
--
L
S
I
V
D
S
V
S
-
G
N
Y
D
P
V
T
S
E
R
V
M
R
Q
V
I
D
S
G
---
I
P
F
D
A
V
Y
C
H
N
D
D
I
A
M
G
V
L
E
A
L
K
K
A
----
K
-
I
S--
G
--
K
I
V
V
G
I
D
G
N
R
A
I
L
E
A
V
D
M
-
K
S
-
M
D
A
T
V
V
Q
S
A
E
E
M
M
K
V
A
F
S
A
L
K
L
H
T
K
N
--
K
K
-
I
P
D
-
R
F
Y
T
Y
S
Y
L
Y
D
--
10
PsiBlast_PDB
76.79
37%
-31
- C1 -
2FN9
-
?
A:
[4-265]
---------------------------------------
M
A
I
V
I
S
T
L
N
N
P
W
F
V
V
L
A
E
T
A
K
Q
R
A
E
Q
L
G
Y
E
A
T
I
F
D
S
Q
N
D
T
A
K
E
S
A
H
F
D
A
I
I
A
A
G
Y
D
A
I
I
F
N
P
T
D
A
D
G
S
I
A
N
V
K
R
A
K
E
A
G
I
P
V
F
C
V
D
R
G
---
I
N
A
R
-
G
-
L
A
V
A
Q
I
Y
S
D
N
Y
Y
G
----
G
V
L
A
G
E
Y
F
V
K
F
L
K
E
K
YPD
A
-
K
--
E
I
P
Y
A
E
L
L
G
I
L
S
A
Q
P
T
W
D
R
S
N
G
---------
F
H
S
-
V
V
--
D
-
Q
Y
P
E
--
F
K
M
V
A
Q
Q
S
-
A
E
F
D
R
D
T
A
Y
K
V
T
E
Q
I
L
Q
A
H
---
P
E
I
K
A
I
W
C
G
N
D
A
M
A
L
G
A
M
K
A
C
E
A
A
----
G
-
R
T--
D
--
I
Y
I
F
G
F
D
G
A
E
D
V
I
N
A
I
K
E
G
K
Q
-
I
V
A
T
I
M
Q
F
P
K
L
M
A
R
L
A
V
E
W
A
D
Q
Y
L
R
G
--
E
R
-----------------
32
HHSearch
72.42
32%
13
- C1 -
4YV7
1
?
A:
[39-312]
-----------------------------------
G
A
L
K
I
G
F
S
Q
A
T
Q
Q
S
P
F
Y
V
A
L
T
D
A
A
K
A
E
A
Q
A
Q
G
D
E
L
F
Y
A
D
A
N
G
D
I
T
K
Q
N
N
D
V
Q
D
L
I
T
R
G
I
N
V
L
V
I
N
P
V
D
P
K
G
V
T
P
S
L
A
A
A
E
A
A
G
I
K
V
V
T
V
D
R
P
---
V
--
E
-
S
-
G
A
A
S
F
V
G
R
D
N
K
A
M
----
G
E
L
V
G
K
A
A
V
D
T
L
------
G
-
P
D-
G
G
K
I
I
E
I
Q
G
D
A
G
G
A
V
A
R
D
R
R
D
G
---------
F
Q
A
-
A
V
SG
R
-
P
--
N
--
I
T
I
V
E
G
P
Y
-
C
D
Y
I
R
S
K
A
V
T
A
M
Q
D
L
L
Q
A
H
---
P
D
L
K
G
V
Y
A
Q
N
D
D
M
A
L
G
A
M
Q
V
L
A
E
N
----
N
-
R
T--
D
--
V
K
V
F
G
V
D
G
L
M
E
A
V
R
A
I
A
D
-
G
D
Q
Y
V
A
T
A
L
N
D
P
D
A
E
G
R
L
A
I
Q
T
A
A
K
V
A
R
G
--
E
S
-
V
P
E
-
F
V
D
A
G
T
G
L
V
D
K
S
12
PsiBlast_PDB
72.14
33%
12
- C1 -
4YV7
1
?
A:
[39-308]
--------------------------------
G
A
L
K
---
I
G
F
S
Q
A
T
Q
Q
S
P
F
Y
V
A
L
T
D
A
A
K
A
E
A
Q
A
Q
G
D
E
L
F
Y
A
D
A
N
G
D
I
T
K
Q
N
N
D
V
Q
D
L
I
T
R
G
I
N
V
L
V
I
N
P
V
D
P
K
G
V
T
P
S
L
A
A
A
E
A
A
G
I
K
V
V
T
V
D
R
P
---
V
E
-
S
-
G
-
A
A
-
S
F
V
G
R
D
N
K
A
M
----
G
E
L
V
G
K
A
A
V
D
T
L
------
G
P
D
--
G
G
K
I
I
E
I
Q
G
D
A
G
G
A
V
A
R
D
R
R
D
G
---------
F
Q
A
-
A
V
--
S
-
G
--
R
PN
I
T
I
V
E
G
P
Y
-
C
D
Y
I
R
S
K
A
V
T
A
M
Q
D
L
L
Q
A
H
---
P
D
L
K
G
V
Y
A
Q
N
D
D
M
A
L
G
A
M
Q
V
L
A
E
N
----
N
-
R
T--
D
--
V
K
V
F
G
V
D
G
L
M
E
A
V
R
A
I
A
D
G
D
Q
-
Y
V
A
T
A
L
N
D
P
D
A
E
G
R
L
A
I
Q
T
A
A
K
V
A
R
G
--
E
S
-
V
P
E
-
F
V
D
A
G
T
G
L
----
46
HHSearch
69.13
27%
3
- C1 -
4KQ9
3
?
A:
[6-282]
-----------------------------------
A
G
K
K
V
V
Y
S
T
F
G
A
Q
I
P
F
F
N
R
I
G
E
G
A
K
A
Q
A
T
V
R
R
L
D
F
D
I
S
T
S
E
I
D
P
G
K
Q
I
D
S
I
D
N
A
V
A
Q
Q
P
D
G
L
I
V
S
P
I
D
G
S
A
L
V
P
T
I
K
G
A
V
E
D
G
V
P
V
I
L
L
A
D
G
---
L
S
-
E
D
V
-
G
Q
L
S
F
V
G
S
D
F
A
E
I
----
G
R
L
K
A
T
Y
I
A
D
R
L
------
G
-
D
--
G
G
T
V
A
M
V
N
G
T
R
G
M
S
F
V
E
E
Q
G
E
A
---------
A
R
E
-
V
F
E
-
E
-
R
--
G
--
I
E
I
V
D
D
V
Y
T
K
A
I
T
P
D
E
G
L
T
A
T
Q
N
I
L
T
R
H
---
S
D
V
G
A
I
Y
Y
S
G
D
D
G
A
L
G
G
I
R
A
I
A
A
R
----
N
-
I
APG
K
--
I
M
V
V
G
T
D
A
N
E
G
A
L
A
A
V
R
A
-
G
T
-
M
A
L
T
V
S
Q
C
A
Y
E
Q
G
G
I
A
I
D
V
M
A
D
Y
L
E
T
--
G
K
K
P
D
R
-
R
I
F
T
P
V
I
E
I
D
T
E
30
PsiBlast_CBE
68.71
35%
11
- C1 -
4RY9
8
?
A:
[8-284]
-------------------------------------
F
K
I
G
V
S
M
K
T
L
S
A
P
Y
F
A
A
Q
M
E
A
A
K
A
R
G
K
E
L
G
Y
E
V
L
A
T
D
A
Q
G
K
L
Q
K
Q
I
S
D
V
E
D
L
V
T
R
G
V
K
L
L
I
I
N
P
A
D
S
E
G
L
V
N
A
V
N
N
A
S
A
N
G
V
K
V
V
V
I
D
S
T
---
L
N
P
R
-
A
-
N
F
V
T
Q
V
Q
S
S
N
S
I
N
----
G
A
L
V
G
H
W
V
I
E
E
V
------
G
N
K
--
S
L
K
I
A
L
L
S
G
E
K
G
N
P
V
G
Q
E
R
R
L
G
V
L
S
G
I
I
E
A
Q
L
R
K
-
F
G
--
K
-
A
--
D
--
L
T
V
V
G
Q
G
W
-
G
H
W
N
D
E
G
G
L
K
A
M
E
D
L
L
V
A
N
---
K
D
I
N
M
V
L
G
E
N
D
S
M
V
L
G
A
R
R
A
I
E
S
A
----
G
-
R
---
T
G
I
L
L
V
A
A
A
D
A
Q
K
E
A
L
A
L
I
K
Q
-
G
K
-
Y
G
V
T
G
L
N
D
P
A
L
V
A
R
T
A
I
D
L
G
V
K
V
V
K
G
EV
K
D
-
V
P
K
Q
T
L
T
T
P
-------
11
PsiBlast_PDB
68.01
37%
-11
- C1 -
2FN8
1
?
A:
[5-266]
---------------------------------------
M
A
I
V
I
S
T
L
N
N
P
W
F
V
V
L
A
E
T
A
K
Q
R
A
E
Q
L
G
Y
E
A
T
I
F
D
S
Q
N
D
T
A
K
E
S
A
H
F
D
A
I
I
A
A
G
Y
D
A
I
I
F
N
P
T
D
A
D
G
S
I
A
N
V
K
R
A
K
E
A
G
I
P
V
F
C
V
D
R
G
---
I
N
A
R
-
G
-
L
A
V
A
Q
I
Y
S
D
N
Y
Y
G
G
V
L
M
G
E
Y
F
V
K
F
L
K
E
K
Y
P
D----
A
-
K
--
E
I
P
Y
A
E
L
L
G
I
L
S
A
Q
P
T
W
D
R
S
N
G
---------
F
H
S
-
V
V
--
D
-
Q
YP
E
--
F
K
M
V
A
Q
Q
S
-
A
E
F
D
R
D
T
A
Y
K
V
T
E
Q
I
L
Q
A
H
---
P
E
I
K
A
I
W
C
G
N
D
A
M
A
L
G
A
M
K
A
C
E
A
A
----
G
-
R
T--
D
--
I
Y
I
F
G
F
D
G
A
E
D
V
I
N
A
I
K
E
G
K
Q
-
I
V
A
T
I
M
Q
F
P
K
L
M
A
R
L
A
V
E
W
A
D
Q
Y
L
R
G
--
E
R
-----------------
29
PsiBlast_CBE
67.72
35%
11
- C1 -
4RY9
11
?
B:
[8-284]
-------------------------------------
F
K
I
G
V
S
M
K
T
L
S
A
P
Y
F
A
A
Q
M
E
A
A
K
A
R
G
K
E
L
G
Y
E
V
L
A
T
D
A
Q
G
K
L
Q
K
Q
I
S
D
V
E
D
L
V
T
R
G
V
K
L
L
I
I
N
P
A
D
S
E
G
L
V
N
A
V
N
N
A
S
A
N
G
V
K
V
V
V
I
D
S
T
---
L
N
P
R
-
A
-
N
F
V
T
Q
V
Q
S
S
N
S
I
N
----
G
A
L
V
G
H
W
V
I
E
E
V
------
G
N
K
--
S
L
K
I
A
L
L
S
G
E
K
G
N
P
V
G
Q
E
R
R
L
G
VLSGIIEAQ
L
R
K
-
F
G
--
K
-
A
--
D
--
L
T
V
V
G
Q
G
W
-
G
H
W
N
D
E
G
G
L
K
A
M
E
D
L
L
V
A
N
---
K
D
I
N
M
V
L
G
E
N
D
S
M
V
L
G
A
R
R
A
I
E
S
A
----
G
-
R
---
T
GI
L
L
V
A
A
A
D
A
Q
K
E
A
L
A
L
I
K
Q
-
G
K
-
Y
G
V
T
G
L
N
D
P
A
L
V
A
R
T
A
I
D
L
G
V
K
V
V
K
G
EV
K
D
-
V
P
K
Q
T
L
T
T
P
-------
31
PsiBlast_CBE
54.42
32%
22
- C1 -
4RY0
3
?
A:
[14-263]
-----------------------------------------------
D
N
P
F
F
K
A
E
A
V
G
A
E
A
K
A
K
E
L
G
Y
E
T
L
V
M
T
H
D
D
D
A
N
K
Q
S
E
M
I
D
T
A
I
G
R
G
A
K
A
I
I
L
D
N
A
G
A
D
A
S
V
A
A
V
K
K
A
K
D
A
G
I
P
S
F
L
I
D
R
E
---
I
N
A
T
-
G
-
V
A
V
A
Q
I
V
S
N
N
Y
Q
G
----
A
Q
L
G
A
Q
E
F
V
K
L
M
------
G
-
E
--
K
G
N
Y
V
E
L
V
G
K
E
S
D
T
N
A
G
I
R
S
Q
G
---------
Y
H
D
-
V
I
--
D
-
D
Y
P
E
--
M
K
S
V
A
K
Q
S
-
A
N
W
S
Q
T
E
A
Y
S
K
M
E
T
I
L
Q
A
N
---
P
D
I
K
G
V
I
S
G
N
D
T
M
A
M
G
A
I
A
A
L
Q
A
A
----
G
R
K
---
D
--
V
I
V
V
G
F
D
G
S
N
D
V
R
D
S
I
K
S
-
G
G
-
I
K
A
T
V
L
Q
P
A
Y
A
Q
A
Q
L
A
V
E
Q
A
D
A
Y
I
K
N
--
K
T
-
T
P
K
-------------
18
PsiBlast_PDB
54.12
32%
22
- C1 -
2VK2
1
YTFQ_ECOLI
A:
[27-253]
-------------------------------------------------------------
E
A
E
K
R
G
I
T
L
K
I
A
D
G
Q
Q
K
Q
E
N
Q
I
K
A
V
R
S
F
V
A
Q
G
V
D
A
I
F
I
A
P
V
V
A
T
G
W
E
P
V
L
K
E
A
K
D
A
E
I
P
V
F
L
L
D
R
S
I
D
V
K
D
-
K
-
S
-
L
Y
M
T
T
V
T
A
D
N
I
L
E
----
G
K
L
I
G
D
W
L
V
K
E
V
N
-----
G
-
K
--
P
C
N
V
V
E
L
Q
G
T
V
G
A
S
V
A
I
D
R
K
K
G
---------
F
A
E
-
A
I
--
K
-
N
AP
N
--
I
K
I
I
R
S
Q
S
-
G
D
F
T
R
S
K
G
K
E
V
M
E
S
F
I
K
A
E
N
NG
K
N
I
C
M
V
Y
A
H
N
D
D
M
V
I
G
A
I
Q
A
I
K
E
A
GLKP
G
-
K
---
D
--
I
L
T
G
S
I
D
G
V
P
D
I
Y
K
A
M
M
D
-
G
E
-
A
N
A
S
V
E
L
T
P
N
M
A
G
----------------------------------