@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu39670: (2016-08-06 )
MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSPVIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFSSVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITECERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQIKKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMREFGSAGKAAKQQVG
Atome Classification :
(23 SA)
.........10........20........30........40........50........60.....-...70......--..80........90........100.......110.......120.......130.......140.......150.......---.160-.....-...170.......180-..--..--.--...190.......200.......210--------------------...---------------------.---------------------.---------------------...220.......230.......240.......250.......260.......270.......280.......290
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
F
V
S
M
K
E
L
L
E
D
A
K
REQ
Y
A
I
G
Q
F
NIN
G
L
Q
W
T
K
A
I
L
Q
A
A
Q
K
EQS
P
V
I
AA
A
S
D
R
L
V
D
Y
LG
G
F
K
T
I
A
A
M
-
V
G
A
L
I
E
DM
A
I
T
--
V
P
V
V
L
H
LDHG
S
S
A
E
R
C
R
Q
A
I
D
AGF
S
S
V
M
IDGSHQP
I
D
E
N
I
A
M
T
K
E
V
T
D
Y
A
A
KHG
V
S
V
E
A
E
VGTVGGMEDGLVG-G
V
R
Y
A
D
I
T
---
E
C
E
--
R
I
V
K
E-T
N
I
D
A
L
A
A
A
L
G
S
V
HG--KY--QG--E--PNL
G
F
K
E
M
E
A
I
S
RMTDI
P
L
V
L
HGAS---------------------GI
P
---------------------
Q
---------------------
D
---------------------
Q
I
K
K
A
I
T
LG
H
A
K
I
N
INT
E
C
M
V
A
W
T
D
E
T
R
R
M
F
Q
ENSDLYEPRGYLTP
G
I
E
A
V
E
E
T
V
R
S
K
M
R
E
FGSAG
K
A
A
K
QQVG
2
PsiBlast_PDB
91.40
54%
-51
- C3 -
3Q94
10
?
A:
[6-288]
--
L
V
S
M
K
E
M
L
N
K
A
L
E
G
K
Y
A
V
G
Q
F
N
M
N
N
L
E
W
T
Q
A
I
L
A
A
A
E
E
E
K
S
P
V
I
L
G
V
S
E
G
A
A
R
H
M
T
G
F
K
T
V
V
A
M
-
V
K
A
L
I
E
E
M
N
I
T
--
V
P
V
A
I
H
L
D
H
G
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
H
P
F
E
E
N
V
E
T
T
K
K
V
V
E
Y
A
H
A
R
N
V
S
V
E
A
E
L
G
T
V
G
G
Q
E
D
D
V
I
A
E
G
V
I
Y
A
D
P
A
---
E
C
K
--
H
L
V
E
A
-
T
G
I
D
C
L
A
P
A
L
G
S
V
H
G
--
P
Y
--
K
G
--
E
--
P
N
L
G
F
A
E
M
E
Q
V
R
D
F
T
G
V
P
L
V
L
H
G
G
T
---------------------
G
I
P
---------------------
T
---------------------
A
---------------------
D
I
E
K
A
I
S
L
G
T
S
K
I
N
V
N
T
E
N
Q
I
E
F
T
K
A
V
R
E
V
L
N
K
D
Q
E
V
Y
D
P
R
K
F
I
G
P
G
R
D
A
I
K
A
T
V
I
G
K
I
R
E
F
G
S
N
G
K
A
------
1
PsiBlast_PDB
87.47
56%
-55
- C3 -
4TO8
2
?
A:
[2-285]
-
P
L
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
G
A
A
R
Y
M
S
G
F
Y
T
I
V
K
M
-
V
E
G
L
M
H
D
L
N
I
T
--
I
P
V
A
I
H
L
D
H
G
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
S
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
G
--
D
D
V
V
A
D
G
I
I
Y
A
D
P
K
---
E
C
Q
--
E
L
V
E
K
-
T
G
I
D
A
L
A
P
A
L
G
S
V
H
G
-------------
P
K
L
G
F
K
E
M
E
E
I
G
L
S
T
G
L
P
L
V
L
H
G
G
T
---------------------
G
I
P
---------------------
T
---------------------
K
---------------------
D
I
Q
K
A
I
P
F
G
T
A
K
I
N
V
N
T
E
N
Q
I
A
S
A
K
A
V
R
D
V
L
N
N
D
K
E
V
Y
D
P
R
K
Y
L
G
P
A
R
E
A
I
K
E
T
V
K
G
K
I
K
E
F
G
T
S
N
R
A
------
60
HHSearch
87.26
56%
-53
- C3 -
4TO8
2
?
A:
[2-286]
-
P
L
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
G
A
A
R
Y
M
S
G
F
Y
T
I
V
K
M
-
V
E
G
L
M
H
D
L
N
I
T
--
I
P
V
A
I
H
L
D
H
G
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
S
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
G
--
D
D
V
V
A
D
G
I
I
Y
A
D
P
K
---
E
C
Q
--
E
L
V
E
K
-
T
G
I
D
A
L
A
P
A
L
G
S
V
H
G
-------------
P
K
L
G
F
K
E
M
E
E
I
G
L
S
T
G
L
P
L
V
L
H
G
G
T
---------------------
G
I
P
---------------------
T
---------------------
K
---------------------
D
I
Q
K
A
I
P
F
G
T
A
K
I
N
V
N
T
E
N
Q
I
A
S
A
K
A
V
R
D
V
L
N
N
D
K
E
V
Y
D
P
R
K
Y
L
G
P
A
R
E
A
I
K
E
T
V
K
G
K
I
K
E
F
G
T
S
N
R
A
K
-----
59
HHSearch
85.97
37%
-113
- C3 -
1GVF
11
KBAY_ECOLI
A:
[2-285]
-
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
-
A
L
E
E
I
Y
A
L
-
C
S
A
Y
S
T
T
--
Y
N
--
M
P
L
A
L
H
L
D
H
H
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
---------
S
A
F
L
T
D
P
Q
---
E
A
K
--
R
F
V
E
L
-
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
--
L
Y
--
S
K
--
T
--
P
K
I
D
F
Q
R
L
A
E
I
R
E
V
V
D
V
P
L
V
L
H
G
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
---------------------
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
S
-----
21
PsiBlast_CBE
85.30
56%
-54
- C3 -
4TO8
2
?
B:
[2-285]
-
P
L
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
G
A
A
R
Y
M
S
G
F
Y
T
I
V
K
M
-
V
E
G
L
M
H
D
L
N
I
T
--
I
P
V
A
I
H
L
D
H
G
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
S
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
G
--
D
D
V
V
A
D
G
I
I
Y
A
D
P
K
---
E
C
Q
--
E
L
V
E
K
-
T
G
I
D
A
L
A
P
A
L
G
S
V
H
--------------
P
K
L
G
F
K
E
M
E
E
I
G
L
S
T
G
L
P
L
V
L
H
G
G
T
---------------------
G
I
P
---------------------
T
---------------------
K
---------------------
D
I
Q
K
A
I
P
F
G
T
A
K
I
N
V
N
T
E
N
Q
I
A
S
A
K
A
V
R
D
V
L
N
N
D
K
E
V
Y
D
P
R
K
Y
L
G
P
A
R
E
A
I
K
E
T
V
K
G
K
I
K
E
F
G
T
S
N
R
A
------
10
PsiBlast_PDB
80.99
35%
-66
- C3 -
3C52
4
ALF_HELPY
A:
[2-306]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
-
I
D
M
A
V
G
M
-
V
K
I
M
C
E
R
Y
P
-
H
--
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
------------
V
L
V
N
P
K
E
A
E
--
Q
F
V
K
E
-
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
AF
K
F
--
K
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
L
T
N
I
P
L
V
L
H
G
A
S
AIP
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
GSK
G
V
P
---------------------
F
---------------------
E
---------------------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
-------
37
PsiBlast_CBE
80.67
35%
-67
- C3 -
3C56
3
ALF_HELPY
B:
[2-306]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
-
I
D
M
A
V
G
M
-
V
K
I
M
C
E
R
Y
P
-
H
--
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
--------------
V
L
V
N
P
K
E
A
E
--
Q
F
V
K
E
-
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
AF
K
F
--
K
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
L
T
N
I
P
L
V
L
H
G
A
S
AIP
D
N
V
R
K
S
Y
L
D
A
GGDLKGSK
G
V
P
---------------------
F
---------------------
E
---------------------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
-------
11
PsiBlast_PDB
80.53
35%
-66
- C3 -
3C56
3
ALF_HELPY
A:
[2-306]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
-
I
D
M
A
V
G
M
-
V
K
I
M
C
E
R
Y
P
-
H
--
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
-----------
A
V
L
V
N
P
K
E
A
E
--
Q
F
V
K
E
-
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
AF
K
F
--
K
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
L
T
N
I
P
L
V
L
H
G
A
S
AIP
D
N
V
R
K
S
Y
L
D
A
GGDLKGSK
G
V
P
---------------------
F
---------------------
E
---------------------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
-------
31
PsiBlast_CBE
80.31
35%
-67
- C3 -
3N9S
5
?
B:
[2-306]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
-
I
D
M
A
V
G
M
-
V
K
I
M
C
E
R
Y
P
-
H
--
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
-------------
A
V
L
V
N
P
K
E
A
E
--
Q
F
V
K
E
-
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
AF
K
F
--
K
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
L
T
N
I
P
L
V
L
H
G
A
S
AIP
D
N
V
R
K
S
Y
L
D
A
GGDLKGSK
G
V
P
---------------------
F
---------------------
E
---------------------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
-------
6
PsiBlast_PDB
80.16
39%
-58
- C3 -
1RV8
7
?
A:
[2-305]
--
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
--
G
G
R
A
L
T
L
M
-
A
V
E
L
A
K
E
A
--
R
--
V
P
V
A
V
H
L
D
H
G
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
---------
K
D
A
L
L
T
---
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
--
A
Y
--
K
G
--
K
G
R
P
F
I
D
H
A
R
L
E
R
I
A
R
L
V
P
A
P
L
V
L
H
G
A
S
---------------------
A
V
P
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
EAAGIH
P
---------------------
E
---------------------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
------
13
PsiBlast_PDB
80.07
35%
-61
- C3 -
3N9S
5
?
A:
[2-306]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
-
I
D
M
A
V
G
M
-
V
K
I
M
C
E
R
Y
P
-
H
--
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
E
D
N
I
S
V
-
D
E
K
D
A
V
L
V
N
P
K
E
A
E
--
Q
F
V
K
E
-
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
AF
K
F
--
K
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
L
T
N
I
P
L
V
L
H
G
A
S
AIP
D
N
V
R
K
S
Y
L
D
A
GGDLKGSK
G
V
P
---------------------
F
---------------------
E
---------------------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
-------
62
HHSearch
79.94
42%
-40
- C3 -
1RVG
8
?
A:
[1-305]
-
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
G
-
G
-
R
A
L
T
L
M
-
A
V
E
L
A
K
E
--
A
R
--
V
P
V
A
V
H
L
D
H
G
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
----K
D
A
L
L
T
N
P
E
---
E
A
R
--
I
F
M
E
R
-
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
--
A
Y
--
K
G
K
G
R
--
P
F
I
D
H
A
R
L
E
R
I
A
R
L
V
P
A
P
L
V
L
H
G
A
S
AVP
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
EAA
G
I
H
---------------------
P
---------------------
E
---------------------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
------
9
PsiBlast_PDB
79.41
35%
-66
- C3 -
3C4U
2
ALF_HELPY
A:
[2-306]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
-
I
D
M
A
V
G
M
-
V
K
I
M
C
E
R
Y
P
-
H
--
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
----------------
V
L
V
N
P
K
E
A
E
--
Q
F
V
K
E
-
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
AF
K
F
--
K
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
L
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
GGDLKGSK
G
V
P
---------------------
F
---------------------
E
---------------------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
-------
38
PsiBlast_CBE
78.95
35%
-65
- C3 -
3C4U
2
ALF_HELPY
B:
[2-306]
--
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
-
I
D
M
A
V
G
M
-
V
K
I
M
C
E
R
Y
P
-
H
--
I
P
V
A
L
H
L
D
H
G
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
----------------
V
L
V
NPK
E
A
E
--
Q
F
V
K
E
-
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
AF
K
F
--
K
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
L
T
N
I
P
L
V
L
H
G
A
S
AIPDNVRKSYLDAGGDLKGSK
G
V
P
---------------------
F
---------------------
E
---------------------
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
-------
58
HHSearch
78.76
39%
-63
* C3 *
2ISW
2
?
A:
[2-310]
-
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
-
D
M
I
Y
L
K
K
L
-
C
E
A
A
L
E
K
-
H
P
D
--
I
P
I
C
I
H
L
D
H
G
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-----------
V
Q
L
T
E
P
Q
---
D
A
K
--
K
F
V
E
L
-
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
--
A
Y
--
K
F
KS----
R
L
A
I
D
R
V
K
T
I
S
D
L
T
G
I
P
L
V
M
H
G
S
S
SVP
K
D
V
K
D
M
I
N
K
Y
GGKMPDAV
G
V
P
---------------------
I
---------------------
E
---------------------
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
---
14
PsiBlast_PDB
78.68
39%
-54
- C3 -
2FJK
1
ALF_THECA
A:
[2-305]
--
L
V
T
G
L
E
I
L
R
K
A
R
A
E
G
Y
G
V
G
A
F
N
T
N
N
M
E
F
T
Q
A
I
L
E
A
A
E
E
M
K
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
--
G
G
R
A
L
T
R
M
-
V
V
A
L
A
Q
E
A
--
R
--
V
P
V
A
V
H
L
D
H
G
S
S
Y
E
S
V
L
K
A
L
R
E
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
K
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
-
D
E
K
D
A
L
L
T
---
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
--
A
Y
--
K
G
--
K
GR
P
F
I
D
H
P
R
L
A
R
I
A
K
L
V
P
A
P
L
V
L
H
G
A
S
---------------------
A
V
P
---------------------
Q
E
L
V
E
R
F
R
A
A
G
G
E
I
G
EASGIH
P
E
---------------------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
V
R
E
T
L
G
K
N
P
K
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
------
4
PsiBlast_PDB
78.65
35%
-75
- C3 -
2ISV
2
?
A:
[2-312]
-
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
-
S
D
M
I
Y
L
K
K
L
-
C
E
A
A
L
E
K
H
P
-
D
--
I
P
I
C
I
H
L
D
H
G
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
---------------
L
T
E
P
Q
---
D
A
K
--
K
F
V
E
L
-
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
--
A
-----------
R
L
A
I
D
R
V
K
T
I
S
D
L
T
G
I
P
L
V
M
H
G
S
S
---------------------
S
V
P
---------------------
K
---------------------
D
V
K
D
M
I
N
K
Y
GGKMPDAVGVP
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
-
7
PsiBlast_PDB
78.57
39%
-59
- C3 -
1RVG
8
?
A:
[2-305]
--
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
--
G
G
R
A
L
T
L
M
-
A
V
E
L
A
K
E
A
--
R
--
V
P
V
A
V
H
L
D
H
G
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
-------
K
D
A
L
L
T
---
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
--
A
Y
--
K
G
--
K
G
R
P
F
I
D
H
A
R
L
E
R
I
A
R
L
V
P
A
P
L
V
L
H
G
A
S
---------------------
A
V
P
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
EAAGIH
P
---------------------
E
---------------------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
------
24
PsiBlast_CBE
78.43
39%
-53
- C3 -
1RVG
5
?
D:
[2-305]
--
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
--
G
G
R
A
L
T
L
M
-
A
V
E
L
A
K
E
A
--
R
--
V
P
V
A
V
H
L
D
H
G
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
-
D
E
K
D
A
L
L
T
---
N
P
E
EA
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
--
A
Y
--
K
G
--
K
GR
P
F
I
D
H
A
R
L
E
R
I
A
R
L
V
P
A
P
L
V
L
H
G
A
S
---------------------
A
V
P
PELVERFRASGGEIGEAAGIH
P
---------------------
E
---------------------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
------
25
PsiBlast_CBE
78.21
39%
-55
- C3 -
1RVG
6
?
C:
[2-305]
--
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
--
G
G
R
A
L
T
L
M
-
A
V
E
L
A
K
E
A
--
R
--
V
P
V
A
V
H
L
D
H
G
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
-
D
E
K
D
A
L
L
T
---
N
P
E
EA
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
--
A
Y
--
K
G
--
K
GR
P
F
I
D
H
A
R
L
E
R
I
A
R
L
V
P
A
P
L
V
L
H
G
A
S
---------------------
A
V
P
PELVERFRASGGEIGEAAGIH
P
---------------------
E
---------------------
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
------
23
PsiBlast_CBE
77.67
35%
-62
- C3 -
2ISV
2
?
B:
[2-312]
-
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
-
S
D
M
I
Y
L
K
K
L
-
C
E
A
A
L
E
K
H
P
-
D
--
I
P
I
C
I
H
L
D
H
G
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
---------
Q
N
-
T
V
Q
L
T
E
P
Q
---
D
A
K
--
K
F
V
E
L
-
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
--
A
Y
KF-------
I
R
L
A
I
D
R
V
K
T
I
S
D
L
T
G
I
P
L
V
M
H
G
S
S
---------------------
S
V
P
---------------------
K
---------------------
D
V
K
D
M
I
N
K
Y
GGKMPDAVGVP
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
-
8
PsiBlast_PDB
68.12
38%
-7
- C3 -
1GVF
11
KBAY_ECOLI
A:
[2-283]
-
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
------
G
T
F
K
H
I
A
L
E
E
I
Y
A
L
C
S
A
Y
S
T
T
Y
N
M
P
L
A
L
H
L
D
H
H
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
------------
S
A
F
L
T
D
P
Q
E
A
K
--
R
F
V
E
L
-
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
--
L
Y
--
S
K
--
T
--
P
K
I
D
F
Q
R
L
A
E
I
R
E
V
V
D
V
P
L
V
L
H
G
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
---------------------
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
-------
30
PsiBlast_CBE
67.23
38%
2
- C3 -
1GVF
12
KBAY_ECOLI
B:
[2-283]
-
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
------
G
T
F
K
H
I
A
L
E
E
I
Y
A
L
C
S
A
Y
S
T
T
Y
N
M
P
L
A
L
H
L
D
H
H
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
G
V
E
---------
S
A
F
L
T
D
P
Q
E
A
K
--
R
F
V
E
L
-
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
--
L
Y
--
S
K
--
T
--
P
K
I
D
F
Q
R
L
A
E
I
R
E
V
V
D
V
P
L
V
L
H
G
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
---------------------
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
-------