@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu40840: (2016-08-08 )
MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDLADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLFVFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFCAMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGEYAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAVWIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKWILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSSGSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQI
Atome Classification :
(20 SA)
.........10........20........30..-......40........50......-.------.------60---.--------.--------------.------......70........80........90.-.-...----...100.......110..------------------.------------------.-----.----.--------------------.----120...----....130.......140.......150.........160-----.......-..170.......180----.------------------------.--.-------.----.....-------------190-..-..-.-.-...-200.-.-.--.-....210.....-.--.---220.......--230----------------.........240------------.---....-------....250-------------.......---..260..--------------..-.-.-.----270-.......280.-.......290......--.300---.----..----------..---...310...------....320.....---------..330...------....340-.........350-------.-----------.---------.-----.---..----.360--.....-....370.......380...-----------------....390.......400..-.-....410..------...------.--.420....-----....430.......440........450-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNTIFKQKNTHPF
S
N
A
A
N
R
L
D
RLP
I
S
R
V
H
F
Q
V
L
-
T
A
L
G
I
V
Y
F
F
D
L
A
D
L
F
T
L
S
N
V
A
P
A
L
-
I
------
E
------H----W--------G--------------I------
P
L
S
T
I
A
N
V
T
A
A
S
F
L
G
M
F
L
G
A
SLG
G
R
L
S
D
R
-I-GR
K
----
K
A
L
N
L
F
V
F
V
F
S
I
A
S
L
C
N
A
------------------
A
------------------A-----W----D--------------------
I
----
P
S
L
M
T
F
----
R
F
L
T
G
F
G
V
A
A
A
M
V
I
T
N
S
Y
L
A
E
FF
P
S
--SVR
G
K
Y
I
S
F
C
-------
A
M
I
GLIG-V
P
I
T
N
I
V
S
A
F
V
IP------L------------------------G--S-------W----
G
W
R
L
V
-------------
F
---
V
W
-
G
A
-
V
-
G
-
L
I
Y
-
F
-
F
F
-
I
-
H
--
R
-LEESPRWHENRG-E--Y---
A
K
A
D
A
I
L
T
R
I
--
E
------------------
E
Q
V
E
KEKGPL--------------P---AASQ-------P
K
V
S
E
---------------
T
V
K
QNAG---
Y
A
G
LLKG--------------R
N
-
L
-
K
-
I
----
T
I
V
-
L
S
A
V
W
I
F
E
T
-
F
-
G
F
Y
G
F
A
S
W
V
P
S
L
L
K
SN--GVT----M----
E
N
----------
T
L
---
W
Y
N
V
L
H
SVG------
A
P
L
G
A
L
L
G
S
M
I
S
---------
E
R
F
Q
R
K
W
I
------
L
A
A
S
A
---
F
L
T
A
I
A
G
L
L
Y
G
M
-------
T
-----------
F
---------
I
-----
P
---
I
M
----
I
I
----
V
F
G
F
I
-
V
N
I
T
E
R
V
F
TSNL
Y
A
YTSEPY-----------------PTEYRSSGS
G
L
A
Y
G
L
G
R
F
S
-
N
-
I
F
G
S
L
L
V
G
F
------
I
A
V
------
Q
--
L
G
-
Y
I
S
V
F
-----
L
F
IG
G
C
W
L
A
C
S
L
L
L
I
F
-FGPNTNAKQI--------
24
HHSearch
81.12
21%
-118
- C3 -
4GC0
5
XYLE_ECOLI
A:
[7-468]
-------------------------
S
S
Y
I
F
S
I
T
-
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
-
N
------
T
------
V
----
F
--------
V
APQNLS
E
S
------
A
------
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
-
F
-
G
R
R
----
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
------------------
W
PELGFTSINPDNTVPVYL
A
-----
G
----
Y
--------------------
V
----
P
E
F
V
I
Y
----
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
--
H
I
R
G
K
L
V
S
F
N
-------
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
------
S
GD
A
S
W
L
------------------
N
--
T
-------
D
----
G
W
R
Y
M
-------------
F
---
A
S
-
E
C
-
I
-
P
-
A
L
L
-
F
-
L
M
L
L
-
Y
--
T
-
V
P
E
S
P
R
W
L
M
S
R
G
-
K
--
Q
---
E
Q
A
E
G
I
------
L
------------------
R
K
I
M
G
N
T
L
A
T
--------------
Q
----
A
-
V
-------
Q
E
I
K
H
---------------
S
L
D
H
--
G
----
R
K
-
T
G
G
--------------
R
L
-
L
-
M
-
F
GVG
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
-
V
-
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
--
G
A
S
----
T
----
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
I
------
N
L
T
F
T
V
L
A
I
M
T
V
---------
D
K
F
G
R
K
P
L
------
Q
I
I
G
A
---
L
G
M
A
I
G
M
F
S
L
G
T
-------
A
F
Y
T
--------
Q
A--------
P
-----
G
---
I
V
----
A
L
----
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
-----------------
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
-
N
-
Y
F
V
S
W
T
F
P
M
------
M
D
K
N
S
W
L
V
A
H
--
F
H
-
N
G
F
S
Y
-----
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
-
F
V
P
E
T
K
G
-----------
44
Fugue
79.50
23%
-131
- C3 -
4QIQ
1
XYLE_ECOLI
A:
[7-470]
-
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
----
V
-
E
S
L
N
T
V
F
------------
V
A
P
Q
N
-
L
------
S
-----------
E
--------
S
--------------
A
------
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
-
F
-
G
R
R
----
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
-----
G
----
Y
--------------------
V
----
P
E
F
V
I
Y
----
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
--
H
I
R
G
K
L
V
S
F
N
-------
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
SGD
A
S
W
L
------------------------
N
--
T
-------
D
----
G
W
R
Y
M
-------------
F
---
A
S
-
E
C
-
I
P
A
-
L
L
F
-
L
-
M
L
-
L
-
Y
--
T
-
V
P
E
S
P
R
W
L
M
T
--------------------------------------------------
L
--------------
A
---
T
Q
A
V
-------
Q
E
I
K
H
---------------
S
L
D
R
L
L
M
---
F
G
V
G
V
I
V
--------------
I
G
-
V
-
M
-
L
----
S
I
F
-
Q
Q
F
V
--------
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
--
G
A
S
----
T
----
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
I
------
N
L
T
F
T
V
L
A
I
M
T
V
---------
D
K
F
G
R
K
P
L
------
Q
I
I
G
A
---
L
G
M
A
I
G
M
F
S
L
G
T
-------
A
-----------
F
---------
Y
T
QAP
G
I
---
V
A
----
L
L
----
S
M
L
F
Y
-
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
-----------------
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
-
N
-
Y
F
V
S
W
T
F
P
M
------
M
D
K
------
N
--
S
W
-
L
V
A
H
F
HNGF
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
--------
42
Fugue
76.35
21%
-110
- C3 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
----------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
-
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
S
----------------------
E
--------
S
--------------
A
------
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
-
F
-
G
R
R
----
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
-----
G
----
Y
--------------------
V
----
P
E
F
V
I
Y
----
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
--
H
I
R
G
K
L
V
S
F
N
-------
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
------
S
------------------------
G
--
D
A
S
W
L
N
T
-
D
----
G
W
R
Y
M
-------------
F
---
A
S
-
E
C
-
I
-
P
-
A
L
L
-
F
-
L
M
-
L
-
L
--
Y
T
V
P
E
S
P
R
W
L
M
S
R
G
-
K
--
Q
---
E
Q
A
E
G
I
L
R
K
I
MG
N
------------------
T
L
A
T
Q
A
V
Q
E
I
--------------
K
---
H
S
L
D
-------
H
G
R
K
T
---------------
G
G
R
L
L
M
F
--------
G
V
--------------
G
V
-
I
-
V
-
I
----
G
V
M
-
L
S
I
F
Q
Q
F
---
V
-
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
--
G
A
S
----
T
----
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
I
------
N
L
T
F
T
V
L
A
I
M
T
V
---------
D
K
F
G
R
K
P
L
------
Q
I
I
G
A
---
L
G
M
A
I
G
M
F
S
L
G
T
-------
A
-----------
F
Y
T
QAP
G
---
I
-----
V
---
A
L
----
L
S
----
M
L
F
Y
V
-
A
A
F
A
-
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
-----------------
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
-
N
-
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
------
H
--
F
H
-
N
G
F
S
Y
-----
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
-
F
V
P
E
T
K
G
K
T
L
EELEALWE
23
HHSearch
69.64
20%
-126
* C3 *
4LDS
-
?
A:
[7-425]
------------------------------
L
I
F
-
I
L
G
A
L
G
G
L
L
Y
G
Y
D
N
G
V
I
S
G
A
L
L
F
I
-
H
------
K
------
D
----
I
--------
P
--------------
L
------
N
S
T
T
E
G
I
V
V
S
S
M
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
-
L
-
G
R
R
----
R
L
V
M
L
I
A
I
V
F
I
I
G
A
L
I
L
A
------------------
A
------------------
S
-----
T
----
N
--------------------
L
----
A
L
L
I
I
G
----
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
--
E
Y
R
G
S
L
G
S
L
N
-------
Q
L
M
I
T
I
G
-
I
L
A
A
Y
L
V
N
Y
A
F
A
D
----------------------------------
I
-------
E
----
G
W
R
W
M
-------------
L
---
G
L
-
A
V
-
V
-
P
-
S
V
I
-
L
-
L
V
G
I
-
Y
--
F
-
M
P
E
S
P
R
W
L
L
E
N
R
-
N
--
E
---
E
A
A
R
Q
V
M
-
K
I
--
T
------------------
Y
D
D
S
E
I
D
K
E
L
--------------
K
------
E
-------
M
K
E
-
I
---------------
N
A
I
S
E
S
T
----
W
T
V
I
K
S
--------------
P
W
-
L
-
G
-
R
I
---
L
I
V
-
G
C
I
F
A
I
F
Q
Q
F
I
-
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
A
--
G
L
G
----
E
----
A
A
----------
S
I
---
L
G
S
V
G
I
G
T
I
------
N
V
L
V
T
I
V
A
I
F
V
V
---------
D
K
I
D
R
K
K
L
------
L
V
G
G
N
---
I
G
M
I
A
S
L
L
I
M
A
I
L
I
W
T
IGI
A
-----------
S
---------
S
-----
A
---
W
I
----
I
I
V
C
L
S
L
F
I
V
F
-
F
G
I
S
---
W
G
P
V
L
W
V
M
L
P
E
L
F
-----------------
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
-
T
-
L
I
V
S
L
F
F
P
I
------
L
S
D
------
A
--
L
S
-
T
E
W
V
F
-----
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
-
F
L
P
E
T
-------------
21
HHSearch
67.02
16%
-122
- C3 -
4J05
1
?
A:
[32-508]
---------------------------
P
Q
I
K
L
V
-
L
L
A
G
V
G
F
F
L
D
A
Y
D
L
F
I
I
N
Q
V
A
P
M
L
-
A
------
Q
------
V
YFPK
T
--------
G
--------------
L
------
P
A
Q
R
Q
D
L
M
K
A
A
A
N
I
G
C
V
V
G
Q
V
M
F
G
V
L
G
D
S
-
F
-
G
R
K
----
F
V
Y
G
K
E
L
I
L
I
I
V
A
T
I
F
Q
M
------------------
S
------------------
A
-----
P
----
S
HWD
G
N
R
V
-------------
L
----
T
W
I
T
I
C
----
R
V
F
L
G
I
G
I
G
G
D
Y
P
M
S
A
T
V
V
S
D
R
A
N
I
--
H
R
R
G
T
L
L
C
F
I
-------
F
A
N
Q
G
W
G
-
S
F
V
G
S
L
V
T
I
V
T
I
S
------
G
F
K
H
RLKSGHTHD------------
V
--
D
-------
K
----
A
W
R
I
L
-------------
I
---
G
L
-
S
L
-
I
-
P
-
A
F
G
-
T
-
L
Y
-
Q
R--------------------------------------------------------------------------------------------------------------------------WQE
F
V
A
Y
F
S
T
--------------
W
N
H
F
-
R
-
N
----
L
L
G
-
S
M
L
G
W
F
L
V
D
-
I
-
A
F
Y
G
I
N
L
N
Q
S
V
V
L
A
Q
I
--
G
F
A
----
G
----
K
T
GD
V
Y
D
K
L
F
Q
L
A
T
---
G
N
I
I
V
T
A
L
G
------
F
L
P
G
Y
Y
F
T
L
F
L
I
---------
D
I
V
G
R
K
K
L
------
Q
F
M
G
F
---
I
M
S
G
L
F
L
A
I
L
A
G
E
------
I
-----------
D
---------
H
IG---
K
G
--
P
L
----
L
A
----
C
F
T
F
M
-
Q
F
F
F
N
F
G
A
N
T
T
T
F
I
V
A
A
E
L
F
-----------------
P
T
R
I
R
A
S
A
H
G
I
S
A
A
A
G
K
C
G
-
A
-
I
L
S
S
L
V
F
N
Q
------
L
K
A
------
K
--
I
G
-
T
S
A
V
L
-----
W
I
F
F
S
T
C
I
L
G
F
I
S
-
T
F
-
L
I
D
E
T
M
G
V
D
---------
7
PsiBlast_PDB
66.51
20%
-130
- C3 -
4J05
1
?
A:
[41-494]
-------------------------------------
G
V
G
F
F
L
D
A
Y
D
L
F
I
I
N
Q
V
A
P
M
L
-
A
------
Q
------
V
----
Y
FPKT----
G
--------------
L
------
P
A
Q
R
Q
D
L
M
K
A
A
A
N
I
G
C
V
V
G
Q
V
M
F
G
V
L
G
D
S
-
F
-
G
R
K
FVYG
K
E
L
-
I
L
I
I
V
A
T
I
F
Q
M
S
A
P
------------------
S
------------------
H
-----
W
----
D
--------------------
G
----
N
R
V
L
T
W
I
T
I
C
R
V
F
L
G
I
G
I
G
G
D
Y
P
M
S
A
T
V
V
S
D
R
A
N
I
--
H
R
R
G
T
L
L
C
F
I
F
A
N
Q
G
W
G
S
F
V
G
S
L
V
-
T
I
V
T
--
I
S
G
F
K
H
R
------
L
------------------------
K
--
S
GHTHD
V
D
K
----
A
W
R
I
L
-------------
I
G
L
S
L
I
-
P
A
-
F
-
G
-
T
L
Y
-
Q
-
R
----------------------------------------------------------------------------------------------------------------------------------------WQE
F
V
A
Y
F
STWNHF
R
N
-
L
-
L
-
G
----
S
M
L
----
G
W
F
L
V
D
-
I
-
A
F
Y
G
I
N
L
N
Q
S
V
V
L
A
Q
I
--
G
F
A
----
G
----
K
T
----------
G
D
---
V
Y
D
K
L
F
Q
L
A
T
G
N
I
I
V
T
A
L
G
F
L
P
G
Y
Y
F
T
L
F
L
I
DIVG
R
K
K
L
Q
F
M
G
F
------
I
M
S
G
L
---
F
L
A
I
L
A
G
E
I
D
H
I
-------
G
-----------
K
---------
G
-----
P
---
L
L
----
A
C
----
F
T
F
M
Q
-
F
F
F
N
F
G
A
N
T
T
T
-
F
I
V
A
A
E
L
F
-----------------
P
T
R
I
R
A
S
A
H
G
I
S
A
A
A
G
K
C
G
-
A
-
I
L
S
S
L
V
F
N
Q
------
L
K
A
------
K
--
I
G
-
T
S
A
V
L
W
----
I
F
F
S
T
C
I
L
G
--------------------------
43
Fugue
65.05
14%
-123
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
-
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
------
E
------
Q
-------------
G
--------------
F
------
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
-
S
-
N
P
R
----
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
M
G
------------------
F
------------------
V
-----
P
----
W
--------------------
A
T
S
SI
A
V
M
F
V
L
----
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
--
K
E
R
G
G
I
V
S
V
W
-------
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
W
------
F
------------------------
N
--
D
-------
W
----
H
A
A
L
Y
-------------
M
---
P
A
-
F
C
-
A
-
I
-
L
V
A
-
L
-
F
A
-
F
-
A
--
M
-
M
R
D
T
P
Q
S
C
G
L
P
-------------------------------------------
P
I
E
E
Y
K
N
--------------
D
---
T
A
K
Q
-------
I
F
M
Q
Y
---------------
V
L
P
N
--------------------------------
K
-
L
----
L
W
Y
-
I
A
I
A
N
V
F
V
Y
-
L
-
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K-
H
F
A
----
L
----
D
K
----------
S
S
---
W
A
Y
F
L
Y
E
Y
A
------
G
I
P
G
T
L
L
C
G
W
M
S
---------
D
K
V
F
R
G
N
R
------
G
A
T
G
V
---
F
F
M
T
L
V
T
I
A
T
I
V
-------
Y
-----------
W
---------
M
NPAGN
P
---
T
V
----
D
M
----
I
C
M
I
V
-
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
-----------------
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
-
V
A
A
S
A
I
V
G
Y
------
T
V
D
------
F
--
F
G
-
W
D
G
G
F
-----
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
-
V
M
I
G
E
K
R
R
H
E
Q
LLQELVP
33
HHSearch
63.29
14%
-140
- C3 -
4W6V
-
?
A:
[27-490]
----------------------------------------
E
M
W
E
R
F
S
F
Y
G
I
R
P
L
L
I
L
F
-
M
------
A
ATVFDG
G
----
M
--------
G
--------------
L
------
P
R
E
Q
A
S
A
I
V
G
I
F
A
G
S
M
Y
L
A
A
L
P
G
G
L
L
A
D
N
-
W
L
G
Q
Q
----
R
A
V
W
Y
G
S
I
L
I
A
L
G
H
L
S
I
A
------------------
L
------------------
S
-----
A
FF--
G
--------------------
N
----
D
L
F
F
I
G
----
L
V
F
I
V
L
G
T
G
L
F
K
T
C
I
S
V
M
V
G
T
L
Y
K
P
GD
A
R
R
D
G
G
F
S
L
F
-------
Y
M
G
I
N
M
G
-
S
F
I
A
P
L
L
S
G
W
L
L
R
----------------------------------
T
-------
H
----
G
W
H
W
G
-------------
F
---
G
I
-
G
G
-
I
-
G
-
M
L
V
A
L
-
L
I
-
F
-
R
G
F
A
-
I
P
A
M
K
R
Y
D
A
E
V
G
-
L
--
D
---
S
S
W
N
K
----
P
--
T
------------------------
G
R
W
V
T
A
I
M
A
V
V
V
V
I
I
A
L
I
S
Q
G
V
I
P
I
N
-------
P
V
M
I
A
S
L
L
V
Y
V
I
A
A
S
V
T
L
Y
F
I
Y
L
F
A
F
A
----
K
M
S
R
K
D
--------------
R
A
-
R
-
L
-
L
V
---
C
F
I
-
L
L
V
S
A
A
F
F
W
-
S
-
A
F
E
Q
K
P
T
S
F
N
L
F
A
N
D
Y
T-
D
R
M
VMGF
E
----
I
P
----------
T
V
---
W
F
Q
S
I
N
A
L
F
------
I
I
L
L
A
P
V
F
S
W
A
------------------PS
S
I
T
K
F
V
I
G
I
---
L
C
A
A
A
G
F
A
V
M
M
Y
-------
A
A
Q
H
V
L
S
S
G
GAG
V
---------
S
-----
P
---
L
W
----
L
V
----
M
S
I
L
L
-
L
T
L
G
E
L
C
L
S
P
I
G
L
A
T
M
T
L
L
A
-----------------
P
D
R
M
R
G
Q
V
M
G
L
W
F
C
A
S
S
L
G
-
N
-
L
A
A
G
L
I
G
G
H
------
V
K
A
------
D
QL
D
M
-
L
P
T
L
F
-----
A
R
C
S
I
A
L
V
I
C
A
A
V
----------------------
27
HHSearch
62.73
13%
-93
- C3 -
4PYP
1
GTR1_HUMAN
A:
[9-455]
-------------------------
T
G
R
L
M
L
A
V
-
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
-
E
------
E
------
F
----
Y
T
Q
T
W
V
H
R
Y
G
--------------
E
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
-
F
-
G
R
R
----
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
------------------
F
------------------
S
KLG--
K
----
S
--------------------
F
----
E
M
L
I
L
G
----
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
--
A
L
R
G
A
L
G
T
L
H
-------
Q
L
G
I
V
V
G
-
I
L
I
A
Q
V
F
G
L
D
S
I
M
------
G
------------------------
N
--
K
-------
D
----
L
W
P
L
L
-------------
L
---
S
I
-
I
F
-
I
-
P
-
A
L
L
-
Q
-
C
I
V
L
-
P
--
F
-
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
---
A
K
S
V
L
K
K
L
R
G
--
T
------------------
A
D
V
T
H
D
L
Q
E
M
--------------
K
-----
E
E
-------
S
R
Q
M
M
---------------
R
E
K
K
V
T
I
----
L
E
L
F
R
S
--------------
P
A
-
Y
R
Q
-
P
----
I
L
I
-
A
V
V
L
Q
L
S
Q
Q
-
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
--
G
V
Q
----------
Q
----------
P
V
---
Y
A
T
I
G
S
G
I
V
------
N
T
A
F
T
V
V
S
L
F
V
V
---------
Q
R
A
G
R
R
T
L
------
H
L
I
G
L
---
A
G
M
A
G
C
A
I
L
M
T
I
-------
A
L
A
LLE------
Q
---------
L
P----
W
M
S
Y
L
S
----
I
V
----
A
I
F
G
F
-
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
-----------------
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
-
N
-
F
I
V
G
M
C
F
Q
Y
------
V
E
Q
------
L
--
C
G
-
P
-
Y
V
F
-----
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
-
K
V
P
E
T
-------------
5
PsiBlast_PDB
62.61
23%
-78
- C3 -
4GC0
4
XYLE_ECOLI
A:
[55-363]
---------------------------------------------------------------------------------------------------------------
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
-
F
-
G
R
R
----
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
--
G
------------------
S
------------------
A
-----
W
----
P
ELGFTSINPDNTVPVYLAGY
V
----
P
E
F
V
I
Y
----
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
--
H
I
R
G
K
L
V
S
F
N
-------
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
------
S
------------------------
G
D
A
S
-------
W
L
N
T
D
G
W
R
Y
M
-------------
F
---
A
S
-
E
C
-
I
P
A
-
L
L
F
-
L
-
M
L
-
L
-
Y
--
T
-
V
P
E
S
P
R
W
L
M
S
R
G
-
K
--
Q
---
E
Q
A
E
G
I
L
R
K
I
--
M
------------------
G
N
T
------
L
--------------
A
---
T
Q
A
V
-------
Q
E
I
K
H
---------------
S
L
D
H
G
R
K
---
T
G
G
R
L
L
M
--------------
F
G
-
V
-
G
-
V
----
I
V
I
-
G
V
M
L
S
I
F
Q
Q
-
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
--
G
A
S
----
T
----
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
I
------
N
L
T
F
T
V
L
A
I
M
T
V
---------
D
K
F
G
R
K
P
L
------
Q
I
I
G
A
---
L
G
M
A
I
G
M
F
S
L
G
T
-------
A
-----------
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
62.49
23%
-76
- C3 -
4GBZ
4
XYLE_ECOLI
A:
[55-363]
---------------------------------------------------------------------------------------------------------------
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
-
F
-
G
R
R
----
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
--
G
------------------
S
------------------
A
-----
W
----
P
ELGFTSINPDNTVPVYLAGY
V
----
P
E
F
V
I
Y
----
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
--
H
I
R
G
K
L
V
S
F
N
-------
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
------
S
------------------------
G
D
A
S
-------
W
L
N
T
D
G
W
R
Y
M
-------------
F
---
A
S
-
E
C
-
I
P
A
-
L
L
F
-
L
-
M
L
-
L
-
Y
--
T
-
V
P
E
S
P
R
W
L
M
S
R
G
-
K
--
Q
---
E
Q
A
E
G
I
L
R
K
I
--
M
------------------
G
N
T
------
L
--------------
A
---
T
Q
A
V
-------
Q
E
I
K
H
---------------
S
L
D
H
G
R
K
---
T
G
G
R
L
L
M
--------------
F
G
-
V
-
G
-
V
----
I
V
I
-
G
V
M
L
S
I
F
Q
Q
-
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
--
G
A
S
----
T
----
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
I
------
N
L
T
F
T
V
L
A
I
M
T
V
---------
D
K
F
G
R
K
P
L
------
Q
I
I
G
A
---
L
G
M
A
I
G
M
F
S
L
G
T
-------
A
-----------
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.40
23%
-81
- C3 -
4GBY
4
XYLE_ECOLI
A:
[55-363]
---------------------------------------------------------------------------------------------------------------
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
-
F
-
G
R
R
----
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
--
G
------------------
S
------------------
A
-----
W
----
P
ELGFTSINPDNTVPVYLAGY
V
----
P
E
F
V
I
Y
----
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
--
H
I
R
G
K
L
V
S
F
N
-------
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
------
S
------------------------
G
D
A
S
-------
W
L
N
T
D
G
W
R
Y
M
-------------
F
---
A
S
-
E
C
-
I
P
A
-
L
L
F
-
L
-
M
L
-
L
-
Y
--
T
-
V
P
E
S
P
R
W
L
M
S
R
G
-
K
--
Q
---
E
Q
A
E
G
I
L
R
K
I
--
M
------------------
G
N
T
------
L
--------------
A
---
T
Q
A
V
-------
Q
E
I
K
H
---------------
S
L
D
H
G
R
K
---
T
G
G
R
L
L
M
--------------
F
G
-
V
-
G
-
V
----
I
V
I
-
G
V
M
L
S
I
F
Q
Q
-
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
--
G
A
S
----
T
----
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
I
------
N
L
T
F
T
V
L
A
I
M
T
V
---------
D
K
F
G
R
K
P
L
------
Q
I
I
G
A
---
L
G
M
A
I
G
M
F
S
L
G
T
-------
A
-----------
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
62.18
15%
-131
- C3 -
1PW4
-
GLPT_ECOLI
A:
[22-430]
-----------------------
T
Y
R
R
L
R
W
Q
I
F
-
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
-------------
E
----
Q
--------
G
--------------
F
------
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
-
S
-
N
P
R
----
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
M
G
------------------
F
------------------
V
-----
P
W
A
T
S
S
--------------------
I
----
A
V
M
F
V
L
----
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
--
K
E
R
G
G
I
V
S
V
W
-------
N
C
A
H
N
V
G
-
G
G
I
P
P
L
L
F
L
L
G
M
A
-------------------------------
W
--
F
-------
N
----
D
W
H
A
A
-------------
L
---
Y
M
-
P
A
F
C
-
A
-
I
L
V
-
A
-
L
F
-
A
-
F
A
-
M
-
M
R
D
T
P
Q
S
C
G
L
P
P
-
I
--
E
---
E
Y
K
---------
N
------------------
D
-----------------------------------------------------------
T
A
K
Q
I
F
---
M
Q
Y
V
L
P
N
--------------
K
L
-
L
-
W
-
Y
--------
I
A
I
A
N
V
F
V
Y
-
L
-
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K-
H
F
A
----
L
----
D
K
----------
S
S
---
W
A
Y
F
L
Y
E
Y
A
------
G
I
P
G
T
L
L
C
G
W
M
S
---------
D
K
V
F
R
G
N
R
------
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
-------
N
PA---------
G
---------
N
-----
P
---
T
V
----
D
M
----
I
C
M
I
V
-
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
-----------------
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
-
G
S
V
A
A
S
A
I
V
G
Y
------
T
V
D
------
F
--
F
G
-
W
D
G
G
F
-----
M
V
M
I
G
G
S
I
L
A
V
I
L
----------------------
22
HHSearch
61.00
15%
-111
- C3 -
4ZW9
4
GTR3_HUMAN
A:
[28-457]
------------------------
V
T
P
A
L
I
F
A
I
-
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
-
K
------
E
------
F
----
I
--------
T
K
T
L
T
D
K
GNAPPS
E
V
L
------
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
-
F
-
G
R
R
----
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
------------------
L
CKV---------------
A
-----
K
----
S
--------------------
V
----
E
M
L
I
L
G
----
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
--
A
L
R
G
A
F
G
T
L
N
-------
Q
L
G
I
V
V
G
-
I
L
V
A
Q
I
F
G
L
E
F
I
L
------
G
------------------------
S
--
E
-------
E
----
L
W
P
L
L
-------------
L
---
G
F
-
T
I
-
L
-
P
-
A
I
L
-
Q
-
S
A
-
A
L
P
--
F
-
C
P
E
S
P
R
F
L
L
I
N
R
-
K
--
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
--
T
------------------
Q
D
V
S
Q
D
I
Q
E
M
--------------
K
---
D
--
E
-------
S
A
R
M
S
---------------
Q
E
K
Q
V
T
V
----
L
E
L
F
R
V
--------------
S
S
-
Y
-
R
-
Q
P
---
I
I
I
-
S
I
V
L
Q
L
S
Q
Q
-
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
--
G
------
V
----
Q
E
----------
P
I
---
Y
A
T
I
G
A
G
V
V
------
N
T
I
F
T
V
V
S
L
F
L
V
---------
E
R
A
G
R
R
T
L
------
H
M
I
G
L
---
G
G
M
A
F
C
S
T
L
M
T
V
-------
S
-----------
L
L
L
KDNY
N
G
M
S
-----
F
---
V
C
----
I
G
----
A
I
L
V
F
-
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
-----------------
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
-
N
-
F
L
V
G
L
L
F
P
S
------
A
A
H
------
Y
--
L
G
-
A
Y
V
F
I
-----
I
F
---------------------------------
35
HHSearch
60.95
18%
-134
- C3 -
4ZP0
3
MDFA_ECOLI
A:
[10-369]
-------------------------------
F
P
-
L
C
L
V
L
Y
E
F
S
T
Y
I
G
N
D
M
I
Q
P
G
M
L
A
V
-
V
------
E
------
Q
----
Y
--------
Q
--------------
A
------
G
I
D
W
V
P
T
S
M
T
A
Y
L
A
G
G
M
F
L
Q
W
L
L
G
P
L
S
D
R
-
I
-
G
R
R
----
P
V
M
L
A
G
V
V
W
F
I
V
T
C
L
A
I
L
------------------
L
------------------
A
-----
Q
----
N
--------------------
I
----
E
Q
F
T
L
L
----
R
F
L
Q
G
I
S
L
C
F
I
G
A
V
G
Y
A
A
I
R
E
S
F
E
E
--
A
V
C
I
K
I
T
A
L
M
-------
A
N
V
A
L
I
A
-
P
L
L
G
P
L
V
G
A
A
W
I
H
----------------------------------
V
-------
L
----
P
W
E
G
M
-------------
F
---
V
L
-
F
A
-
A
-
L
A
A
I
S
-
F
-
F
G
-
L
-
Q
R
-
A
-
M
P
E
T
A
T
R
I
G
-------
E
----
K
----------
L
--------------------
S
L
K
----------------------------------
E
--------------------
L
-
G
R
D
Y
----
K
L
V
L
K
N
--------------
G
R
-
F
-
V
-
A
----
G
A
----
L
A
L
G
F
V
S
-
L
-
P
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
G
E-
Q
L
S
----
S
----
Y
E
----------
Y
G
---
L
L
Q
V
P
I
F
G
A
------
L
I
A
G
N
L
L
L
A
R
L
T
---------
S
R
R
T
V
R
S
L
------
I
I
M
G
G
---
W
P
I
M
I
G
L
L
V
A
A
A
A
T
V
I
---
S
-----------
S
H--------
A
-----
Y
---
L
W
----
M
T
A
G
L
S
I
Y
A
F
G
-
I
G
L
A
----
N
A
G
L
V
R
-
L
T
L
F
A
-----------------
S
D
M
S
K
G
T
V
S
A
A
M
G
M
L
Q
M
L
I
-
F
-
T
V
G
I
E
I
S
K
H
------
A
W
L
------
N
--
G
G
-
N
--------------------------------------------
37
HHSearch
58.73
16%
-116
- C3 -
3WDO
-
?
A:
[25-381]
--------------------------------------------
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
-
G
M-----
A
------
L
----
Q
--------
G
--------------
A
------
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
-
I
-
G
R
K
----
P
L
I
V
G
G
L
A
V
F
A
A
G
S
V
I
A
A
------------------
L
------------------
S
-----
D
----
S
--------------------
I
----
W
G
I
I
L
G
----
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
--
Q
N
R
T
K
A
M
A
F
I
-------
G
V
S
F
G
I
T
-
F
A
I
A
M
V
L
G
P
I
I
T
H
----------------------------------
K
-------
L
----
G
L
H
A
L
-------------
F
---
W
M
-
I
A
-
I
-
L
-
A
T
T
G
I
-
A
L
-
T
-
I
W
-
V
-
V
P
N
S
S
T
H
V
L
N
R
E
--------------------
S
--------------------
G
M
-----------------------------------
V
----------------------
K
G
S
F
----
S
K
V
L
A
E
--------------
P
R
-
L
-
L
-
K
----
L
N
----
F
G
I
M
C
L
H
-
M
-
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
--
G
F
P
----
A
----
A
E
----------
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
------
S
V
V
P
F
I
I
Y
A
E
V
K
---------
R
K
M
K
Q
--
V
------
F
V
F
C
V
---
G
L
I
V
V
A
E
I
V
L
W
N
-------
A
Q----------
T
---------
Q
-----
F
---
W
Q
----
L
V
----
V
G
V
Q
L
-
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
-----------------
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
-
V
-
A
I
G
G
S
L
G
G
W
------
I
D
G
------
M
--
F
D
-
G
Q
G
V
F
-----
L
A
G
A
M
L
A
A
V
W
-------------------------
26
HHSearch
58.31
18%
-98
- C3 -
4YB9
-
GTR5_BOVIN
D:
[70-462]
----------------------------------------------------------------------------------------------------------------
L
W
S
V
T
V
S
M
F
P
F
G
G
F
L
G
S
L
M
V
G
P
L
V
N
N
-
L
-
G
R
K
----
G
T
L
L
F
N
N
I
F
S
I
V
P
A
L
L
M
G
------------------
F
------------------
S
ELA--
K
----
S
--------------------
F
----
E
M
I
I
V
A
----
R
V
L
V
G
I
C
A
G
L
S
S
N
V
V
P
M
Y
L
G
E
L
A
P
K
--
N
W
R
G
A
L
G
V
V
P
-------
Q
L
F
I
T
I
G
-
I
L
V
A
Q
I
F
G
L
R
S
L
L
------
A
------------------------
N
--
E
-------
E
----
G
W
P
I
L
-------------
L
---
G
L
-
T
G
-
I
-
P
-
A
V
L
Q
L
-
L
F
-
L
-
P
--
F
-
F
P
E
S
P
R
Y
L
L
I
Q
K
-
K
--
D
EAA
A
K
S
A
L
R
R
L
---------------------------
A
E
I
E
E
I
--------------
L
---
E
--
E
-------
D
R
A
E
K
---------------
A
V
G
F
I
S
V
----
L
K
L
F
K
M
--------------
R
S
-
L
-
R
W
Q
----
V
I
S
-
I
I
V
L
M
A
G
Q
Q
-
L
S
G
V
N
A
I
Y
Y
Y
A
D
Q
I
Y
L
S
A
--
G
V
N
----
E
----
D
D
----------
V
Q
---
Y
V
T
A
G
T
G
A
V
------
N
V
L
I
T
V
C
A
I
F
V
V
---------
E
L
M
G
R
R
F
L
------
L
L
L
G
F
---
S
V
C
F
T
A
C
C
V
L
T
G
-------
A
LAL--------
Q
DV-------
I
S----
W
MP-
Y
V
----
S
I
ACVI
S
Y
V
I
G
-
H
A
L
G
---
P
S
P
I
P
A
L
L
V
T
E
I
F
-----------------
L
Q
S
S
R
P
A
A
Y
M
V
A
G
T
V
H
W
L
S
-
N
-
F
T
V
G
L
V
F
P
F
------
I
Q
V
------
G
--
L
G
-
A
-
Y
S
F
-----
V
I
F
A
V
I
C
L
L
T
T
V
Y
I
F
L
-
I
I
P
E
--------------
31
HHSearch
57.75
12%
-121
- C3 -
4IKV
11
?
A:
[32-480]
----------------------------------------
E
F
W
E
R
F
S
Y
Y
G
M
R
A
I
L
V
Y
Y
-
M
Y
YEVSK
G
------
G
----
L
--------
G
--------------
L
------
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
D
R
V
F
-
G
T
S
----
R
A
V
F
Y
G
G
L
L
I
M
A
G
H
I
A
L
A
------------------
I
------------------
P
-----
G
----
G
--------------------
V
----
A
A
L
F
V
S
----
M
A
L
I
V
L
G
T
G
L
L
K
P
N
V
S
S
I
V
G
D
M
Y
K
P
GD
D
R
R
D
A
G
F
S
I
F
-------
Y
M
G
I
N
L
G
-
A
F
L
A
P
L
V
V
G
T
A
G
M
----------------------------------
K
-------
Y
----
N
F
H
L
G
-------------
F
---
G
L
-
A
A
-
V
-
G
-
M
F
L
-
G
L
V
V
-
F
-
V
--
A
-
T
R
K
K
N
L
G
L
A
G
T
Y
V
P
--
N
---
P
L
T
P
A
E
K
K
K
A
--
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
G
W
F
T
V
E
T
F
--------------
I
---
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
---------------
V
M
Y
R
S
P
K
----
T
T
A
E
E
R
--------------
S
R
-
V
-
I
-
A
----
Y
I
P
-
L
F
V
A
S
A
M
F
W
-
A
-
I
Q
E
Q
G
S
T
I
L
A
N
Y
A
D
K
R
T-
Q
L
D
----
V
AG
I
H
L
S
----------
P
A
---
W
F
Q
S
L
N
P
L
F
------
I
I
I
L
A
P
V
F
A
W
M
W
---------
V
K
L
G
K
R
Q
P
T
I
P
Q
K
-
F
A
L
G
L
---
L
F
A
G
L
S
F
I
V
I
L
V
-------
P
-----------
G
H
L
S
GGGLV-
H
-----
P
---
I
W
----
L
V
----
L
S
Y
F
I
-
V
V
L
G
E
L
C
L
S
P
V
G
L
S
A
T
T
K
L
A
-----------------
P
A
A
F
S
A
Q
T
M
S
L
W
F
L
S
N
A
A
A
-
Q
-
A
I
N
A
Q
L
V
R
F
------
Y
T
P
------
E
---
N
-
E
T
A
Y
F
-----
G
T
I
G
G
A
A
L
V
L
G
L
I
----------------------
28
HHSearch
57.34
16%
-112
- C3 -
4U4V
7
NARK_ECOLI
A:
[56-451]
---------------------------------------------------
S
A
V
A
V
N
L
P
K
------
V
------
G
----
F
--------
N
--------------
F
------
T
T
D
Q
L
F
M
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
V
P
I
-
F
-
G
G
R
----
R
W
T
A
F
S
T
G
I
L
I
I
P
C
V
W
L
G
------------------
F
------------------
A
V
Q
D
TS
T
----
P
--------------------
Y
----
S
V
F
I
I
I
----
S
L
L
C
G
F
A
G
A
-
N
F
A
S
S
M
A
N
I
S
F
F
F
P
K
--
Q
K
Q
G
G
A
L
G
L
N
-------
G
G
L
G
N
M
G
-
V
S
V
M
Q
L
V
A
P
L
V
V
S
------
L
SIF---------------------
A
--
V
-------
F
----
G
S
Q
G
V
K
Q
PDGTELY
L
A
N
A
S
---
W
I
W
V
P
-
F
-
L
-
A
I
F
-
T
-
I
A
-
A
-
W
F
-
G
-
M
N
D
L
A
T
-------------------------------------------------------------------------------------------------------------------
L
P
V
L
K
R
--------------
G
H
-
L
-
W
-
I
----
M
----
S
L
L
Y
L
A
T
F
-
G
-
S
F
I
G
F
S
A
G
F
A
M
L
S
-
K
T
--
Q
F
P
----
D
----
V
Q
----------
I
L
---
Q
Y
A
F
F
G
P
F
I
------
G
A
L
A
R
S
A
G
G
A
L
S
---------
D
R
L
G
G
T
R
V
------
T
L
V
N
F
---
I
L
M
A
I
F
S
G
L
L
F
L
-------
T
L----------
P
TDQGG----
S
-----
F
---
M
A
F
F
A
V
F
L
----
A
L
F
L
T
-
A
G
L
G
S
G
S
T
F
Q
M
I
S
V
I
F
R
K
L
T
M
D
R
V
K
A
E
GGS
D
E
R
A
M
R
E
A
A
T
D
T
A
A
A
L
G
F
I
S
A
I
G
A
I
G
-
G
-
F
F
I
P
K
A
F
G
S
------
S
L
A
------
L
--
T
G
S
P
V
G
A
M
-----
K
V
F
L
I
F
Y
I
A
C
V
V
-----------------------
29
HHSearch
55.94
13%
-145
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[22-421]
---------------------------
R
S
Y
I
I
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
-
Q
------
Q
------
A
----
F
--------
T
--------------
L
------
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
-
L
-
S
Y
K
----
A
G
I
I
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
------------------
P
------------------
A
A
E
I
--
M
----
N
--------------------
Y
----
T
L
F
L
V
G
----
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
--
S
S
G
H
F
R
L
N
L
A
-------
Q
T
F
N
S
F
G
-
A
I
I
A
V
V
F
G
Q
S
L
I
L
------
S
NVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
--
V
-------
L
----
S
V
Q
T
P
-------------
Y
---
M
I
I
V
A
-
I
-
V
-
L
L
V
-
A
-
L
L
-
I
-
M
L
T
K
-
F
P
A
L
Q
S
D
N
--------
H
---
S
D
----------
A
--------------------
K
-
Q
----------------------------------
G
S
-------------------
F
-
S
A
S
L
----
S
R
L
A
R
I
--------------
R
H
-
W
-
R
-
W
----
A
----
V
L
A
Q
F
C
Y
V
-
G
-
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
IP
G
M
T
----
A
----
G
F
----------
A
A
---
N
Y
L
T
G
T
M
V
C
------
F
F
I
G
R
F
T
G
T
W
L
I
---------
S
R
F
A
P
H
K
V
------
L
A
A
Y
A
---
L
I
A
M
A
L
C
L
I
S
A
F
-------
A
-----------
G
---------
G
-----
H
---
V
G
----
L
I
----
A
L
-
T
L
-
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
-----------------
G
Q
D
T
K
-
Y
G
S
S
F
I
-
V
M
T
I
I
G
-
G
-
G
I
V
T
P
V
M
G
F
------
V
S
D
------
A
--
A
G
N
I
P
T
A
E
-----
L
I
P
A
L
C
-----------------------------