@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0142: (2016-04-19 )
MRSIDVVVEAVVTFAGAAGFAHTLAPLRRGQQDPCFRVPGDGTIWRTSLLPTGPVTARISRAGRDAARCVAWGSGAEEFVDMAPAMLGAADDASDFVPLHPAVAAAHRRLPNLRLGRTGQVLEALIPAVIEQRVPGADAFRSWRLLVSKYGTQAPGPAPPGMRVPPSAEVWRHIPSWEFHRANVDPGRARAVVGCAQRAASLERLVSLPAARAAEALTSLPGVGVWTAAETTQRVFGDADAVSVGDYHIPKMIGWTLVGRPVDDAGMLELLEPMRPHRHRVVRLLEASGLAREPRRGPRLPVQNIRAL
Atome Classification :
(20 SA)
-----------------------------------------------.......----..10........20--------........30........40....-----------....50........60..---......-----70.--.......80---.........90......---..----100.---------------..-----......110--.....--.--.--.-.------120......----.130....-...140.......--150.......160......-----.170.----..----..-.----.----180-.....-.---..190.....--..200-----.-------.-----.-----.....-----.210.......220.----..------.....230.......----240----........250.......260-------.---.......270-........280...-....290........300......-------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------MR
S
I
D
V
V
----
V
E
A
V
V
T
F
AGAAG
F
A
--------
H
T
L
A
P
L
RRGQQDP
C
F
RVPGDG
T
I
W
-----------
R
T
SLLPTGP
V
T
A
R
I
S
RAG---R
D
A
A
R
C
-----VAW--GS
G
A
E
E
F
V
----
D
M
A
P
A
M
LGAADDASDFV---PL----
H
--
P
---------------
A
V
-----
A
A
A
H
RRL----PNLRL--G--R--
T
-
G
------
Q
V
L
E
A
L
I
P
A
----
V
I
E
QRVP
G
-
A
D
A
F
R
S
W
R
L
L
V
S
K--YGTQAPGPAPPGMRVP
P
S
A
-----
E
V
W
R
H----IP----S
W
-
E
----
F
----HR--ANVDP-G---
R
A
R
A
V
V
G
C
A
Q
--
R
A
A
-------
S
-------
L
-----
E
-----
R
L
V
SL-----
P
A
A
R
A
A
E
A
L
TSLP-G----VG------VW
T
A
A
E
T
T
Q
R
V
FGDA----DA-----VSVGDYH
I
P
K
M
I
G
W
T
LVGR-P-------V---D
D
A
G
M
L
E
L
-
L
-
E
PMR
P
H
R
H
R
V
V
R
L
L
-
E
ASGL-AREPRRGPRL
P
V
Q
NIRAL-------------------
8
HHSearch
73.53
15%
-88
- C6 -
2JHN
8
?
A:
[2-288]
------------------------------------------------------------
W
R
I
E
L
K
H
A
V
N
W
E
--------
L
K
M
K
F
F
V
L
P
E
L
P
T
P
D
V
V
E
S
-
G
V
W
R
-----------
R
A
I
V
L
D
G
R
A
V
A
V
M
A
Y
P
E
S
---
E
R
T
I
V
V
-----
E
G
N
FE
N
R
E
W
E
A
V
R
----
R
K
L
V
E
Y
L
G
L
Q
-
N
P
E
E
L
Y
---
R
F
M
D
G
-
D
--
E
---------------
K
L
-----
R
M
L
K
N
R
F
----
Y
G
F
G
R
--
A
--
G
L
M
S
-
M
------
S
V
F
E
G
I
A
K
A
----
I
I
Q
Q
Q
I
S
F
-
V
V
A
E
K
L
A
A
K
I
V
G
R
--
F
G
D
E
V
E
W
N
-
G
L
K
F
Y
G
F
P
T
Q
-----
E
A
I
L
K
----
A
G
----
V
E
-
G
----
L
----
R
E
--
C
G
L
S
R
-
R
---
K
A
E
L
I
V
E
I
A
K
--
E
E
--------
N
-------
L
-----
E
-----
E
L
K
E
W
-----
G
E
E
E
A
Y
E
Y
L
T
S
F
K
-
G
----
I
G
------
R
W
T
A
E
L
V
L
S
I
A
L
G
K
-----
N
V
-----
F
P
A
D
D
L
G
V
R
R
A
V
S
R
L
Y
F
N
G
E
I
-------
Q
---
S
A
E
K
V
R
E
I
-
A
R
E
R
F
G
R
F
A
R
D
I
L
F
Y
L
-
F
L
Y
D
R
--------------------------------------
29
Fugue
70.82
15%
-79
- C6 -
2JHN
8
?
A:
[1-295]
-----------------------------------------------------------
M
W
R
I
E
L
K
H
A
V
N
W
E
--------
L
K
M
K
F
F
V
L
-
P
E
L
P
T
P
D
V
V
E
S
G
V
W
R
-----------
R
A
I
V
L
D
G
R
A
V
A
V
M
A
Y
P
E
S
---
E
R
T
I
V
V
-----
E
G
N
FE
N
R
E
W
E
A
V
R
----
R
K
L
V
E
Y
L
G
L
Q
N
P
E
E
L
Y
R
---
F
M
----
D
G
D
E
---------------
K
L
-----
R
M
L
K
N
R
F
----
Y
G
F
G
R
A
G
L
--
M
--
S
-
M
------
S
V
F
E
G
I
A
K
A
----
I
I
Q
Q
Q
I
S
F
-
V
V
A
E
K
L
A
A
K
I
V
G
R
--
F
G
D
E
V
E
W
N
-
G
L
K
F
Y
G
F
P
T
Q
-----
E
A
I
L
K
----
A
G
----
V
E
-
G
----
L
----
R
E
--
C
G
L
S
R
-
R
---
K
A
E
L
I
V
E
I
A
K
---
E
E
-------
N
-------
L
-----
E
-----
E
L
K
E
W
-----
G
E
E
E
A
Y
E
Y
L
T
S
F
K
-
G
----
I
G
------
R
W
T
A
E
L
V
L
S
I
A
L
G
-
K
----
N
V
-----
F
P
A
D
D
L
G
V
R
R
A
V
S
R
L
Y
F
N
G
-
E
-------
I
---
Q
S
A
E
K
V
R
E
-
I
-
A
R
E
R
F
G
R
F
A
R
D
I
L
F
-
Y
L
F
L
Y
-
D
R
F
F
S
K
E
L
V
----------------------------
9
HHSearch
70.39
17%
-75
- C6 -
1MPG
1
3MG2_ECOLI
A:
[2-276]
------------------------------------------------------------
Y
T
L
N
W
Q
P
P
Y
D
W
S
--------
W
M
L
G
F
L
A
A
R
A
V
S
S
V
E
T
V
A
-
D
S
Y
Y
A
-----------
R
S
L
A
V
G
E
Y
R
G
V
V
T
A
I
P
D
I
ARH
T
L
H
I
N
L
-----
S
A
G
L-
E
P
V
A
A
E
C
L
----
A
K
M
S
R
L
F
D
L
Q
C
N
P
Q
I
V
----------
N
--
G
---------------
A
L
-----
G
R
L
G
A
A
R
----
P
G
L
R
L
--
P
--
G
--
C
-
V
------
D
A
F
E
Q
G
V
R
A
----
I
L
G
Q
L
V
S
V
-
A
M
A
A
K
L
T
A
R
V
A
Q
L
--
Y
G
E
R
L
D
D
--
F
P
E
Y
I
C
F
P
T
P
-----
Q
R
L
A
A
----
A
D
----
P
Q
-
A
----
L
----
K
A
--
L
G
M
P
L
-
K
---
R
A
E
A
L
I
H
L
A
N
--
A
A
L
-------
E
-------
G
TL---
P
-----
M
T
I
P
G
-----
D
V
E
Q
A
M
K
T
L
Q
T
F
P
-
G
----
I
G
------
R
W
T
A
N
Y
F
A
L
R
G
W
Q
A
K
----
D
V
-----
F
L
P
D
D
Y
L
I
K
Q
R
F
P
G
--------------
M
---
T
P
A
Q
I
R
R
Y
-
A
-
E
R
W
K
P
W
R
S
Y
A
L
L
H
I
-
W
Y
T
E
G
--------------------------------------
34
Fugue
69.97
21%
-55
- C2 -
4CI0
4
?
A:
[2-386]
S
E
R
I
V
I
S
PTSRQE
G
H
A
E
L
V
M
E
V
D
DEGIVT
K
G
R
Y
F
S
ITPVRG
L
E
K
M
V
T
G
K
A
P
E
T
A
----
P
V
M
V
Q
R
I
C
G
V
C
P
I
P
--------
H
T
L
A
S
V
E
A
I
D
D
S
L
D
I
E
V
P
K
A
G
R
L
L
-----------
R
E
L
T
L
A
A
H
H
V
N
S
H
A
I
H
H
F
---
L
I
A
P
D
F
-----
V
P
---
E
N
L
M
A
D
A
I
----
N
S
V
S
E
I
R
K
N
A
Q
Y
V
V
D
M
V
A
GE
G
I
----
H
--
P
SDVRIGGMA
D
N
I
T
E
L
A
R
-----
K
R
L
Y
A
R
L
----
K
Q
L
K
---
P
--
K
--
V
-
N
------
E
H
V
E
L
M
I
G
L
----
I
E
D
K
G
L
P
E
-
G
L
G
V
H
N
Q
P
T
L
A
S
H
QI
Y
G
D
R
T
K
F
D
L
D
R
F
T
E
I
M
P
E
S
WYDD
P
E
I
A
K
R
AC
S
T
I
P
----
L
Y
-
D
----
G
----
R
N
--
V
E
V
G
P
R
A
---
R
M
V
E
F
Q
G
F
K
E
--
R
G
-----------------------------
V
V
A
Q
-----
H
V
A
R
A
L
E
M
K
T
A
L
S
R
A
----
I
E
------
I
L
D
E
L
D
T
S
A
P
V
R
A
D
F
----
D
E
RGTG
K
L
G
I
G
A
I
E
A
P
R
--
G
L
D
V
H
M
A
-
K
-------
V
---
E
N
-
G
K
I
Q
F
-
Y
-
S
A
L
V
P
T
T
W
N
I
P
T
M
G
-
P
A
T
E
G
-
F
H
H
E
Y
-
G
P
H
V
----
I
R
A
Y
DPCLSCATH----------
10
HHSearch
68.03
14%
-78
- C6 -
4EJY
3
?
A:
[28-303]
--------------------------------------------------------------
V
R
G
I
A
D
F
N
L
K
--------
E
T
F
E
S
G
Q
C
F
R
W
N
E
E
---
E
-
D
G
S
Y
T
-----------
G
V
A
--
Y
D
R
--
V
V
N
V
K
L
E
G
---
D
-
T
L
I
I
-----
D
----
N
T
N
L
T
D
F
Y
----
D
I
W
F
D
Y
F
D
L
G
R
D
Y
G
Q
I
K
---
E
S
L
S
K-
D
--
P
---------------
V
L
-----
K
E
A
I
K
F
G
----
Q
G
I
R
I
--
L
--
R
----
Q
------
D
T
W
E
T
L
V
S
F
----
I
V
S
Q
N
N
R
I
-
P
Q
I
K
K
V
I
E
N
L
A
T
S
--
F
G
N
P
I
E
Y
K
-
G
K
I
Y
Y
T
F
P
K
P
-----
E
E
L
V
M
----
Y
D
----
V
E
-
T
----
I
----
A
K
--
T
R
C
G
--
F
---
R
A
K
Y
I
F
D
A
A
S
--
K
V
F
-------
S
GEIN---
L
-----
L
-----
K
L
H
E
Y
-----
S
T
S
E
I
R
D
I
L
M
T
I
N
-
G
----
V
G
------
P
K
V
A
D
C
V
I
L
Y
S
I
G
R
Y
----
D
T
-----
F
P
T
-
D
V
W
I
K
R
I
V
E
H
L
Y
L
K
R
-
E
-------
G
---
T
P
V
E
I
Q
L
F
-
A
I
D
K
F
G
D
L
S
G
F
A
Q
Q
Y
L
-
F
Y
Y
G
R
E
M
G
K
----------------------------------
11
HHSearch
66.41
17%
-96
- C6 -
3I0W
7
?
A:
[68-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
F
K
----
N
V
W
S
E
Y
F
D
L
Y
R
D
Y
G
E
I
K
---
K
E
L
S
R-
D
--
P
---------------
L
L
-----
K
K
S
V
D
F
G
----
E
G
I
R
I
--
L
--
R
----
Q
------
D
P
F
E
I
L
L
S
F
----
I
I
S
A
N
N
R
I
-
P
M
I
K
K
C
I
N
N
I
S
E
K
--
A
G
K
K
L
E
Y
K
-
G
K
I
Y
Y
A
F
P
T
V
-----
D
K
L
H
E
----
F
T
----
E
K
-
D
----
F
----
E
E
--
C
T
A
-
G
-
F
---
R
A
K
Y
L
K
D
T
V
D
--
R
I
Y
-------
N
GELN---
L
-----
E
-----
Y
I
K
S
L
-----
N
D
N
E
C
H
E
E
L
K
K
F
M
-
G
----
V
G
------
P
Q
V
A
D
C
I
M
L
F
S
M
Q
K
Y
----
S
A
-----
F
P
V
-
D
T
W
V
K
K
A
M
M
S
L
Y
V
A
P
-
D
-------
V
---
S
L
K
K
I
R
D
F
-
G
R
E
K
F
G
S
L
S
G
F
A
Q
Q
Y
L
-
F
Y
Y
A
R
--------------------------------------
28
Fugue
64.56
19%
-76
- C6 -
1MPG
1
3MG2_ECOLI
A:
[100-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
R
----
P
G
L
R
L
--
P
--
G
--
C
-
V
------
D
A
F
E
Q
G
V
R
A
----
I
L
G
Q
L
V
S
V
-
A
M
A
A
K
L
T
A
R
V
A
Q
L
--
Y
G
E
R
L
D
D
F
P
E
Y
--
I
C
F
P
T
P
-----
Q
R
L
A
A
----
A
D
----
P
Q
-
A
----
L
----
K
A
--
L
G
M
P
L
-
K
---
R
A
E
A
L
I
H
L
A
N
--
A
A
L
-------
E
GT-----
L
-----
P
-----
M
T
I
P
G
-----
D
V
E
Q
A
M
K
T
L
Q
T
F
P
-
G
----
I
G
------
R
W
T
A
N
Y
F
A
L
R
G
W
Q
A
K
----
D
V
-----
F
L
P
D
D
Y
L
I
K
Q
R
F
------
P
-
G
-------
M
---
T
P
A
Q
I
R
R
Y
-
A
-
E
R
W
K
P
W
R
S
Y
A
L
L
H
I
-
W
Y
T
E
G
-
W
Q
P
D
E
A
-------------------------------
15
HHSearch
64.15
17%
-87
- C6 -
3S6I
3
MAG1_SCHPO
A:
[16-221]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
K
A
E
I
H
L
S
G
L
D
E
N
W
K
R
L
V
---
K
---------------------------------
L
V
G
N
Y
----
R
P
N
R
S
--
M
--
E
--
K
-
K
------
E
P
Y
E
E
L
I
R
A
----
V
A
S
Q
Q
L
H
S
-
K
A
A
N
A
I
F
N
R
F
K
S
I
--
S
N
----------
N
G
Q
F
P
T
P
-----
E
E
I
R
D
----
M
D
----
F
E
-
I
----
M
----
R
A
--
C
G
F
S
A
-
R
---
K
I
D
S
L
K
S
I
A
E
--
A
T
I
-------
S
GL-----
I
PT
K
--
E
-----
E
A
E
R
L
-----
S
N
E
E
L
I
E
R
L
T
Q
I
K
-
G
----
I
G
------
R
W
T
V
E
M
L
L
I
F
S
L
N
R
D
----
D
V
-----
M
P
A
D
D
L
S
I
R
N
G
Y
R
Y
L
H
R
L
P
K
I
-------
P
---
T
K
M
Y
V
L
K
H
-
S
-
E
I
C
A
P
F
R
T
A
A
A
W
Y
L
-
W
K
T
S
K
--
L
A
D
Y
T
K
------------------------------
16
HHSearch
60.72
21%
-81
- C6 -
2YG9
3
?
A:
[39-222]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
P
---------------
V
L
-----
A
Q
V
T
S
L
C
----
G
E
L
P
V
--
L
A
-
P
--
T
-
P
------
D
P
F
G
R
L
V
R
S
----
V
A
G
Q
Q
L
S
V
-
K
A
A
Q
A
I
Y
G
R
L
E
G
L
--
P
G
G
-------------
V
V
P
-----
A
A
L
L
K
----
V
S
----
G
D
-
D
----
L
----
R
G
--
V
G
L
S
W
-
A
---
K
V
R
T
V
Q
A
A
A
A
--
A
A
V
-------
S
GQID---
F
-----
A
-----
H
L
S
G
Q
-----
P
D
E
L
V
I
A
E
L
V
Q
L
P
-
G
----
I
G
------
R
W
T
A
E
M
F
L
L
F
A
L
A
R
P
----
D
V
-----
F
S
S
G
D
L
A
L
R
Q
G
V
E
R
L
Y
P
G
----------------
E
D
W
R
D
V
-
T
-
A
R
W
A
P
Y
R
S
L
A
S
R
Y
L
-
W
A
N
S
A
--
R
M
Q
A
G
G
------------------------------
12
HHSearch
60.61
16%
-85
- C6 -
2XHI
4
OGG1_HUMAN
A:
[104-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
D
E
L
----
E
A
V
R
K
Y
F
Q
L
D
V
T
L
A
Q
L
Y
---
H
H
W
G
S
V
D
--
S
---------------
H
F
-----
Q
E
V
A
Q
K
F
----
Q
G
V
R
L
--
L
--
R
----
Q
------
D
P
I
E
C
L
F
S
F
----
I
C
S
S
N
N
N
I
-
A
R
I
T
G
M
V
E
R
L
C
Q
A
--
F
G
P
R
L
I
Q
L
D
D
V
T
Y
H
G
F
P
S
L
-----
Q
A
L
A
G
----
P
E
----
V
E
A
H
----
L
----
R
K
--
L
G
L
G
--
Y
---
R
A
R
Y
V
S
A
S
A
R
--
A
I
L
-------
E
EQGG
L
A
W
L
-----
Q
-----
Q
L
R
E
S
-----
S
Y
E
E
A
H
K
A
L
C
I
L
P
-
G
----
V
G
------
T
C
V
A
D
K
I
C
L
M
A
L
D
K
P
----
Q
A
-----
V
P
V
-
N
V
H
M
W
H
I
A
Q
R
D
Y
S
W
H
-
P
TTSQAKG
P
S
P
Q
T
N
K
E
L
G
N
F
F
R
-
S
L
W
G
P
Y
A
G
W
A
Q
A
V
L
-
F
S
A
D
L
-
R
------------------------------------
13
HHSearch
59.75
12%
-81
- C6 -
4B21
6
MAG2_SCHPO
A:
[21-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
D
S
D
Y
K
R
A
E
---
K
H
L
S
S
I
D
--
N
---------------
K
W
-----
S
S
L
V
K
K
V
----
G
P
C
T
L
--
T
P
H
P
--
E
-
H
------
A
P
Y
E
G
I
I
R
A
----
I
T
S
Q
K
L
S
D
-
A
A
T
N
S
I
I
N
K
F
C
T
Q
--
C
S
D
---------
N
D
E
F
P
T
P
-----
K
Q
I
M
E
----
T
D
----
V
E
-
T
----
L
----
H
E
--
C
G
F
S
K
-
L
---
K
S
Q
E
I
H
I
V
A
E
--
A
A
L
-------
N
-------
K
QIPS
K
S
-----
E
I
E
K
M
-----
S
E
E
E
L
M
E
S
L
S
K
I
K
-
G
----
V
K
------
R
W
T
I
E
M
Y
S
I
F
T
L
G
R
L
----
D
I
-----
M
P
A
D
D
S
T
L
K
N
E
A
K
E
F
F
G
L
S
S
K
-------
P
---
Q
T
E
E
V
E
K
L
-
T
-
K
P
C
K
P
Y
R
T
I
A
A
W
Y
L
-
W
Q
I
P
K
--------------------------------------
22
HHSearch
58.46
23%
-91
- C6 -
4UNF
4
?
A:
[51-204]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
R
-
R
------
D
P
M
H
E
L
I
S
T
----
I
L
S
Q
R
T
T
H
-
A
D
E
E
A
A
Y
Q
E
L
R
-
T
--
L
---------------
G
D
W
-----
D
A
I
T
L
----
A
P
----
T
D
-
A
V
A
H
A
I
----
R
R
--
S
N
Y
P
E
-
S
---
K
A
P
R
I
Q
E
T
L
R
--
R
I
K
-------
A
APGGYD-
L
-----
D
-----
F
L
R
D
L
-----
P
V
K
D
A
L
K
W
L
T
D
L
P
-
G
----
V
G
------
V
K
T
A
S
L
V
L
L
F
N
Y
A
R
P
-----
V
-----
F
P
V
-
D
T
H
V
H
R
V
S
T
R
V
G
V
I
P
-
R
-------
M
---
G
E
Q
A
A
H
R
A
-
L
-
L
A
L
L
P
P
D
---------------------------------------------------
33
Fugue
57.51
20%
-65
- C3 -
4MB0
-
?
A:
[9-261]
-----------------------------------------------
P
R
Y
W
S
L
Y
----
Y
R
E
K
I
I
E
G
M
E
K
G
M
T
--------
A
K
A
G
L
I
A
H
G
R
G
E
A
F
D
Y
L
I
G
E
R
T
I
--------------------------------------------------
E
P
A
E
R
A
M
----
R
A
A
V
A
K
L
L
L
A
E
N
P
--
V
V
---
S
V
----
N
--
G
---------------
N
V
-----
A
A
L
-
V
P
K
----
E
T
I
E
L
--
A
--
R
--
A
L
N
------
A
K
L
E
I
N
L
F
Y
----
R
T
E
D
R
V
K
A
I
A
E
E
L
R
K
Y
D
--------------
P
E
I
E
L
L
G
I
N
P
T
---------
K
R
----
I
P
----
G
L
-
E
----
H
----
E
R
--
G
K
V
D
E
-
N
GIW
K
A
D
V
V
V
--------------------------------------
V
P
L
-----
E
D
G
D
R
T
E
A
L
V
R
M
--
G
----
K
F
------
V
I
T
I
D
L
N
P
L
S
R
S
A
R
M
----
A
D
-----
I
T
I
V
D
N
I
V
R
A
Y
P
R
M
T
E
L
A
R
-
E
-------
M
---
K
D
Y
S
R
G
E
L
-
I
-
R
I
I
E
E
Y
D
N
G
K
T
L
N
D
-
V
L
L
H
I
-
R
D
R
L
T
K
L
A
E
G
G
I
W
R
K
K
Q
L
D------------------
25
HHSearch
57.38
20%
-95
- C6 -
4UOB
6
?
A:
[61-220]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
P
------
D
P
L
G
G
L
I
R
T
----
I
L
S
Q
Q
N
T
R
-
R
V
A
Q
R
Q
W
E
V
L
T
A
T
--
Y
---------------
P
Q
W
-----
E
A
A
L
L
----
D
G
----
P
D
-
G
I
E
A
T
L
----
K
S
A
G
G
G
L
S
R
-
M
---
K
A
D
Y
I
Y
G
I
L
A
--
H
L
Q
-------
E
HHGGLS-
L
-----
R
-----
F
L
R
E
F
PHT
P
E
G
H
E
Q
A
R
Q
A
L
A
A
L
P
-
G
----
V
G
------
H
K
T
V
A
L
V
L
L
F
D
L
R
R
P
-----
A
-----
M
P
V
-
D
G
N
M
E
R
A
A
K
R
L
E
L
V
P
-
A
A------
W
---
N
S
H
K
V
E
R
W
-
Y
-
A
E
V
M
P
-----------------------------------------------------
30
Fugue
55.86
15%
-54
- C6 -
1EBM
2
OGG1_HUMAN
A:
[1-317]
-------------------------------------------GSEG
H
R
T
L
A
S
T
----
P
A
L
W
A
S
I
P
C
P
R
S
E
L
--------
R
L
D
L
V
L
P
S
G
Q
---
S
F
R
W
R
E
Q
S
P
A
H
-----------
W
S
G
V
L
--
A
D
Q
V
W
T
L
T
Q
T
E
---
E
Q
L
H
C
T
-----
V
Y
R
--
S
Q
A
S
R
P
T
P
----
D
E
L
E
A
V
R
K
Y
F
Q
L
D
V
T
L
A
---
Q
L
----
Y
--
H
---------------
H
W
-----
G
S
V
D
S
H
F
----
Q
E
V
A
Q
--
K
--
F
--
Q
-
G
VRLLRQ
D
P
I
E
C
L
F
S
F
----
I
C
S
S
N
N
N
I
-
A
R
I
T
G
M
V
E
R
L
C
Q
A
--
F
G
P
R
L
I
Q
L
D
D
V
T
Y
H
G
F
P
S
L
-----
Q
A
L
A
G
----
P
E
----
V
E
-
A
----
H
----
L
R
--
K
L
G
L
G
-
Y
---
R
A
R
Y
V
S
A
S
A
R
--
A
I
L
E
EQGG
L
A
W
-------
L
-----
Q
-----
Q
L
R
E
S
-----
S
Y
E
E
A
H
K
A
L
C
I
L
P
-
G
----
V
G
------
T
Q
V
A
D
C
I
C
L
M
A
L
D
K
P
----
Q
A
-----
V
P
V
-
D
V
H
M
W
H
I
A
Q
R
D
Y
S
W
H
-
P
-------
T
---
T
S
Q
A
K
G
P
S
-
P
-
Q
T
N
K
E
L
G
N
F
F
R
S
L
W
G
P
Y
A
G
W
-
A
Q
A
V
L
F
S
A
D
L
R
Q
-------------------------
26
HHSearch
54.07
21%
-68
- C6 -
1ORN
5
?
A:
[30-178]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
R
------
N
P
F
E
L
L
I
A
V
----
V
L
S
A
Q
C
T
D
-
A
L
V
N
K
V
T
K
R
L
F
E
K
--
Y
R
---------------
T
P
-----
H
D
Y
I
A
----
V
P
----
L
E
-
E
L
E
Q
D
I
----
R
S
--
I
G
L
Y
R
-
N
---
K
A
R
N
I
Q
K
L
C
A
--
M
L
I
-------
D
-------
K
-----
Y
--------
N
G
-----
E
V
P
R
D
R
D
E
L
M
K
L
P
-
G
----
V
G
------
R
K
T
A
N
V
V
V
S
V
A
F
G
V
P
-----
A
-----
I
A
V
-
D
T
H
V
E
R
V
S
K
R
L
G
F
C
R
W
D
-------
D
---
S
V
L
E
V
E
K
T
-
L
-
M
K
I
I
P
K
E
E
W
S
------------------------------------------------
35
Fugue
53.11
21%
-44
- C5 -
5CXB
2
?
B:
[1-369]
------------------------------------------------
P
S
P
D
E
L
KPFP
T
V
Q
Q
T
I
F
R
G
H
E
G
R
V
--------
R
S
V
A
I
D
P
T
G
---
V
A
L
A
T
G
G
D
D
G
T
V
-----------
R
V
W
E
L
L
T
G
R
Q
V
W
S
V
K
L
N
G
---
D
E
A
V
N
T
-----
V
R
W
--
R
P
T
K
D
T
F
I
--------
L
A
A
A
A
G
E
D
I
F
L
M
I
---
P
T
----
H
--
P
---------------
S
V
T
P
A
L
D
Q
A
S
R
D
I
L
N
AGF
P
P
G
K
W
--
A
--
R
--
P
-
G
------
T
R
L
E
D
E
-
G
V
----
L
L
R
I
T
V
R
S
-
T
I
K
A
I
S
W
H
R
R
G
D
H
--
F
A
T
V
S
P
S
G
Q
R
S
S
V
A
I
H
T
L
S
-----
K
H
L
T
Q
----
I
P
FRKL
N
G
-
L
----
A
----
Q
T
--
A
S
F
H
P
-
L
---
R
P
L
F
F
V
A
T
Q
R
S
I
R
C
Y
-------
D
-------
L
-----
Q
KLELV
K
I
V
Q
P
-----
G
A
K
W
I
S
S
F
D
V
H
P
G
-
G
D
N
L
V
V
G
S
YDK
R
L
L
W
H
D
L
D
L
S
N
R
P
Y
K
T
M
R
FHT
E
A
-----
I
R
A
V
R
F
H
K
G
---
G
L
P
L
F
A
D
-
A
-------
S
---
D
D
-
G
S
L
Q
I
-
F
-
H
G
K
V
P
N
D
Q
L
E
N
P
T
I
-
V
P
V
K
M
-
L
K
G
H
K
V
V
N
K
L
G
V
L
D
I
D
W
H
PREP
W
C
V
S
A
G
ADG
T
A
R
L
W
M
23
HHSearch
49.74
22%
-65
- C6 -
1KEA
8
GTMR_METTF
A:
[32-192]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
R
------
D
P
Y
V
I
L
I
T
E
----
I
L
L
R
R
T
T
A
-
G
H
V
K
K
I
Y
D
K
F
F
V
K
--
Y
---------------
K
C
F
-----
E
D
I
L
K
----
T
P
----
K
S
-
E
----
I
A
K
D
I
K
E
--
I
G
L
S
N
-
Q
---
R
A
E
Q
L
K
E
L
A
R
--
V
V
I
-------
N
-------
D
-----
Y
--------
G
G
-----
R
V
P
R
N
R
K
A
I
L
D
L
P
-
G
----
V
G
------
K
Y
T
C
A
A
V
M
C
L
A
F
G
K
K
----
A
A
------
M
V
-
D
A
N
F
V
R
V
I
N
R
Y
F
G
G
S
-
Y
ENLN---
Y
---
N
H
K
A
L
W
E
L
-
A
-
E
T
L
V
P
G
G
K
C
R
D
F
N
L
-
G
L
M
D
F
--------------------------------------
14
HHSearch
49.40
15%
-61
- C6 -
2H56
-
?
A:
[2-202]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
F
S
T
D
--
S
P
E
V
K
---
T
I
V
A
Q-
D
--
S
---------------
R
L
-----
F
Q
F
I
E
I
A
----
G
E
V
Q
L
--
P
--
T
--
K
-
P
------
N
P
F
Q
S
L
V
S
S
----
I
V
E
Q
Q
L
S
I
-
K
A
A
S
A
I
Y
G
R
V
E
Q
L
--
V
G
G
A
-----------
L
E
K
P
-----
E
Q
L
Y
R
----
V
S
----
D
E
-
A
----
L
----
R
Q
--
A
G
V
S
K
-
R
---
K
I
E
Y
I
R
H
V
C
E
--
H
V
E
-------
S
GRLD---
F
-----
T
-----
E
L
E
G
A
-----
E
A
T
T
V
I
E
K
L
T
A
I
K
-
G
----
I
G
------
Q
W
T
A
E
M
F
M
M
F
S
L
G
R
L
----
D
V
-----
L
S
V
G
D
V
G
L
Q
R
G
A
K
W
L
Y
G
N
G
E
G
-------
D
---
G
K
K
L
L
I
Y
H
-
G
-
K
A
W
A
P
Y
E
T
V
A
C
L
Y
L
-
W
K
A
A
G
--------------------------------------
32
Fugue
48.67
17%
-38
* C5 *
4RKS
4
MV3K_THEAC
A:
[21-337]
----------------------------------------------T
Y
R
S
I
G
S
T
----
A
Y
P
T
I
G
V
V
L
L
G
G
I
A
NPVTRTPL
H
T
S
A
G
I
A
Y
S
--
D
S
C
G
S
I
R
S
E
T
R
I
Y
A
D
E
A
T
H
I
Y
F
NG
T
E
S
T
D
D
N
R
S
V
R
R
V
L
D
R
Y
S
---
S
V
F
E
E
A
FGTK
T
V
S
Y
--
S
S
Q
N
F
G
I
L
SGSS
D
A
G
A
A
S
I
G
A
A
I
L
G
L
K
P
D
---
L
D
----
P
--
H
---------------
D
V
-----
E
N
D
L
R
A
V
----
S
E
-
S
A
--
G
--
R
--
S
-
L
------
F
G
G
L
T
I
T
W
S
DGF
H
A
Y
T
E
K
I
L
D
-
P
E
A
F
S
G
Y
S
I
V
A
F
A
--
F
D
Y
Q
R
N
----------
P
S
D
-----
V
I
H
Q
N
----
I
V
----
R
S
-
D
----
L
----
Y
P
--
A
R
K
K
H
-
A
---
D
E
H
A
H
M
I
K
E
Y
--
A
K
T
N------
D
-------
I
-----
K
-----
G
I
F
D
L
-----
A
Q
E
D
T
E
E
Y
H
S
I
L
R
-
G
----
V
G
------
V
N
V
I
R
E
N
M
Q
K
L
I
S
Y
L
----
K
L
-----
I
R
K
D
Y
W
N
A
Y
I
V
T
G
G
S
N
V
Y
V
-
A
-------
V
---
E
S
E
N
A
D
R
L
-
F
-
S
I
E
N
T
F
G
-
S
K
K
K
M
L
-
R
I
V
G
G
-
A
W
H
R
R
P
E
------------------------------