@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0490: (2016-04-23 )
MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQALGGEDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRDFVANVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSEAISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRSNRSQREEELSR
Atome Classification :
(26 SA)
.........10........20........30........40........50........60.......---.70........80.-.......90........100----------..-.......110.......120.......130.......140.......150.....----------------..160.......170.......180.....-.-----.-190.......200.......210.......220.......230.......240.--......250-----....------...-260.-.....-..270.......280.......290---..--.....---300.........310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
V
F
S
A
L
L
L
A
G
V
L
S
A
L
A
L
A
VGG
A
V
G
M
R
L
T
S
R
V
V
E
Q
R
Q
R
V
A
T
EWSGI
T
V
S
Q
M
L
Q
C
I
V
T
L
MPLG
A
A
V
VDT---HR
D
V
V
Y
L
N
E
R
A
K
E
L-GLVRDRQL
D
D
Q
A
W
R
A
A
R
Q
------------AL-GGE
D
V
E
F
DLSPRKRSATGRS
G
L
S
VHG
H
A
R
LLSEEDR
R
F
A
V
V
F
V
HDQS
D
Y
A
R
M
E
A
A
----------------
R
R
D
F
V
A
N
V
S
H
E
LKT
P
V
G
A
M
A
L
L
A
E
A
L
LASA-D-----
D
-
S
E
T
V
R
R
F
A
E
K
V
L
I
E
A
N
R
L
G
D
M
V
A
E
L
I
E
L
S
R
LQ
G
A
E
RLPNMTDV
D
V
D
T
I
V
S
E
A
I
S
--RHKVAADNA-----
D
I
E
V
------RTD-AP-S-N
L
R
VL-GD
Q
T
L
L
V
T
A
L
A
N
L
V
S
N
A
IAYSPRG
S
---
L
V
--
S
I
S
R
R---R--RGA
N
I
E
I
A
V
TDRGIGIAP
E
D
Q
E
R
V
F
E
R
F
FRGDKARSRATGGS
G
L
G
L
A
I
V
K
H
V
AANHD
G
T
I
R
V
WSKPGTG
S
T
F
T
L
A
L
P
A
L
I
E
A
YHDDERPEQARE
P
E
L
RSN
R
S
Q
R
E
E
E
LSR
6
PsiBlast_PDB
84.37
31%
-91
- C2 -
4JAV
6
?
A:
[15-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
R
M
----------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
-
G
EL---
D
-
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
V
-----
N
V
L
F
------
E
S
N
-
V
P
-
C
-
P
V
E
A
Y
-
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
--
K
V
I
L
D
---
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---------------------------------
53
HHSearch
82.64
34%
-84
- C2 -
4U7O
1
?
A:
[25-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
----------------
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
-
W
-----
K
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
--
R
F
D
M
I
L
K
K
D
DNPA
K
Y
Y
T
I
------
K
R
E
-
F
T
K
R
-
D
L
W
V
E
-
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
V
--
T
C
R
L
L
---
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
-------------------------------
23
PsiBlast_CBE
81.84
31%
-84
- C2 -
3DGE
2
?
B:
[15-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
R
M
----------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
-
G
EL---
D
-
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
AI
K
E
F
A
S
S
H
N
V
-----
N
V
L
F
------
E
S
N
-
V
P
-
C
-
P
V
E
A
Y
-
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
PDK
Y
V
--
K
V
I
L
D
---
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---------------------------------
22
PsiBlast_CBE
81.70
31%
-90
- C2 -
4JAV
6
?
B:
[15-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
R
M
----------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
-
G
EL---
D
-
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
V
-----
N
V
L
F
------
E
S
N
-
V
P
-
C
-
P
V
E
A
Y
-
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
--
K
V
I
L
D
---
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---------------------------------
5
PsiBlast_PDB
81.53
31%
-86
- C2 -
3DGE
3
?
A:
[15-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
R
M
----------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
-
G
EL---
D
-
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
V
-----
N
V
L
F
------
E
S
N
-
V
P
-
C
-
P
V
E
A
Y
-
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
PD
K
Y
V
--
K
V
I
L
D
---
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---------------------------------
2
PsiBlast_PDB
80.22
35%
-79
- C2 -
4U7O
1
?
A:
[25-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
----------------
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-----
D
-
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
--
R
F
D
M
I
L
K
K
D
-----
D
N
P
A
K
Y
Y
T
I
K
R
E
F
-
T
K
-
R
-
D
L
W
V
E
-
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
V
--
T
C
R
L
L
---
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
--
Y
E
-----------------------------
7
PsiBlast_PDB
80.10
30%
-85
- C2 -
4JAS
2
?
A:
[15-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
R
M
----------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
-
G
EL---
D
-
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
V
-----
N
V
L
F
------
E
S
N
-
V
P
-
C
-
P
V
E
A
Y
-
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
--
K
V
I
L
D
---
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---------------------------------
4
PsiBlast_PDB
79.78
31%
-96
- C2 -
2C2A
2
?
A:
[15-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
R
M
----------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
-
G
EL---
D
-
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
V
-----
N
V
L
F
------
E
S
N
-
V
P
-
C
-
P
V
E
A
Y
-
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
--
K
V
I
L
D
---
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---------------------------------
8
PsiBlast_PDB
79.56
30%
-98
- C2 -
4JAU
1
?
A:
[15-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
R
M
----------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
-
G
EL---
D
-
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
V
-----
N
V
L
F
------
E
S
N
-
V
P
-
C
-
P
V
E
A
Y
-
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
--
K
V
I
L
D
---
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
---------
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---------------------------------
1
PsiBlast_PDB
75.23
35%
-90
- C2 -
4U7N
-
?
A:
[386-610]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-----
D
-
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
--
R
F
D
M
I
L
K
K
D
-----
D
N
--Y
Y
T
I
K
-
R
E
F
-
T
K
-
R
-
D
L
W
V
E
-
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
V
--
T
C
R
L
L
---
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-----------
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
--
Y
E
-----------------------------
10
PsiBlast_PDB
73.64
31%
-79
- C2 -
4BIW
5
CPXA_ECOLI
A:
[75-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
----------------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
-
G
-----
E
-
S
K
E
L
----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
T
-
I
K
A
N
Q
L
W
S
E
V
L
D
--
N
A
A
F
E
A
E
Q
M
-----
G
K
S
L
------
T
V
N
F
P
P
-
G
-
P
W
P
L
Y
-
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
V
--
G
F
A
V
D
---
K
--
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---------------------------------
21
PsiBlast_CBE
73.05
35%
-70
- C2 -
4U7O
1
?
B:
[37-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-----
D
-
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
------
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
--
R
F
D
M
I
L
K
K
D
-----
D
N
P
A
KY
Y
T
I
K
R
E
F
-
T
K
-
R
-
D
L
W
V
E
-
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
V
--
T
C
R
L
L
---
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
R
---
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
--
Y
E
-----------------------------
26
PsiBlast_CBE
71.71
31%
-83
- C2 -
4BIU
2
CPXA_ECOLI
D:
[75-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
----------------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
-
G
-----
E
-
S
K
E
L
----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
T
-
I
K
A
N
Q
L
W
S
E
V
L
D
--
N
A
A
F
E
A
E
Q
M
-----
G
K
S
L
------
T
V
N
F
P
P
-
G
-
P
W
P
L
Y
-
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
V
--
G
F
A
V
D
---
K
--
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---------------------------------
15
PsiBlast_PDB
70.56
30%
-80
- C2 -
4BIV
2
CPXA_ECOLI
A:
[75-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
----------------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
-
G
-----
E
-
S
K
E
L
----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
T
-
I
K
A
N
Q
L
W
S
E
V
L
D
--
N
A
A
F
E
A
E
Q
M
-----
G
K
S
L
------
T
V
N
F
P
P
-
G
-
P
W
P
L
Y
-
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
V
--
G
F
A
V
D
---
K
--
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---------------------------------
9
PsiBlast_PDB
70.50
31%
-90
- C2 -
4BIU
-
CPXA_ECOLI
A:
[75-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
----------------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
-
G
-----
E
-
S
K
E
L
----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
T
-
I
K
A
N
Q
L
W
S
E
V
L
D
--
N
A
A
F
E
A
E
Q
M
-----
G
K
S
L
------
T
V
N
F
P
P
-
G
-
P
W
P
L
Y
-
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
V
--
G
F
A
V
D
---
K
--
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
----------
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---------------------------------
11
PsiBlast_PDB
70.18
31%
-91
- C2 -
4BIX
3
CPXA_ECOLI
A:
[75-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
----------------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
-
G
-----
E
-
S
K
E
L
----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
T
-
I
K
A
N
Q
L
W
S
E
V
L
D
--
N
A
A
F
E
A
E
Q
M
-----
G
K
S
L
------
T
V
N
F
P
P
-
G
-
P
W
P
L
Y
-
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
V
--
G
F
A
V
D
---
K
--
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---------------------------------
55
HHSearch
70.09
30%
-87
- C2 -
4BIX
3
CPXA_ECOLI
A:
[75-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
----------------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
-
G
----------
E
S
K
E
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
-
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
--
N
A
A
F
E
A
E
Q
M
-----
G
K
S
L
------
T
V
N
-
F
P
-
P
G
P
W
P
L
Y
-
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
-----
I
--
E
V
G
F
A
---
V
--
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
------------------------------
25
PsiBlast_CBE
70.08
31%
-89
- C2 -
4BIU
1
CPXA_ECOLI
E:
[75-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
----------------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
-
G
-----
E
-
S
K
E
L
----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
T
-
I
K
A
N
Q
L
W
S
E
V
L
D
--
N
A
A
F
E
A
E
Q
M
-----
G
K
S
L
------
T
V
N
F
P
P
-
G
-
P
W
P
L
Y
-
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
V
--
G
F
A
V
D
---
K
--
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
-------------
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---------------------------------
51
HHSearch
69.81
20%
-68
- C2 -
4GCZ
9
FIXL_BRADU (first)
A:
[13-373]
------------------------------------------------
L
E
V
I
K
K
A
L
D
H
V
R
V
G
V
V
I
T
D
P
ALE
D
N
P
I
V
Y
V
N
Q
G
F
V
Q
M
T
G
Y
E
T
E
E
I
L
G
K
N
C
R
F
L
Q
G
K
HTD
P
A
E
V
D
N
I
R
T
A
L
Q
N
K
E
P
V
T
V
Q
I
Q
N
Y
K
K
---
D
G
T
M
F
W
N
E
L
N
I
D
P
M
E
I
E
D
K
T
Y
F
V
G
I
Q
N
D
I
T
E
H
Q
Q
T
Q
A
R
L
Q
E
L
Q
S
E
L
V
H
V
S
R
L
S
A
M
G
E
M
A
S
A
L
A
H
E
L
N
Q
P
L
A
A
I
S
N
Y
M
K
G
S
R
R
L
L
-
A
GSSDP
N
-
T
P
K
V
E
S
A
L
D
R
A
A
E
Q
A
L
R
A
G
Q
I
I
R
R
L
R
D
F
V
A
R
G
E
S
----
E
K
R
V
E
S
L
S
K
L
I
E
E
A
G
A
--
L
G
L
A
G
A
R
E
Q
-----
N
V
Q
L
------
R
F
S
-
L
D
-
P
G
A
D
L
V
L
-
A
D
R
V
Q
I
Q
Q
V
L
V
N
L
F
R
N
A
L
E
A
M
A
Q
S
Q
---
R
R
--
E
L
V
V
T
N
T
P
A
--
A
D
D
M
I
E
V
E
V
S
D
T
G
S
G
F
Q
D
D
V
I
P
N
L
F
Q
T
F
F
T
T
K
------
D
T
G
M
G
V
G
L
S
I
S
R
S
I
I
E
A
H
G
G
R
M
W
A
E
S
N
A
S
G
G
A
T
F
R
F
T
L
P
A
A
D
------------------------------
14
PsiBlast_PDB
69.78
30%
-76
- C2 -
4Q20
-
DIVL_CAUCR
A:
[535-758]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
A
E
R
L
----------------
K
R
D
F
V
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
L
L
E
R
A
D
---------
S
E
R
G
R
N
H
V
A
A
V
R
A
A
A
T
Q
L
A
R
S
I
D
D
V
L
D
M
A
Q
I
D
A
G
E
M
A
L
E
I
E
D
I
R
V
S
D
L
L
L
N
A
Q
E
--
R
A
L
K
D
A
Q
L
G
-----
G
V
T
L
------
A
V
E
-
C
E
-
E
-
D
V
G
L
I
R
G
D
G
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
P
P
G
G
---
R
V
--
T
L
S
A
R
---
R
--
A
L
G
E
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
D
R
F
V
G
R
D
R
------
G
G
P
G
L
G
L
A
L
V
K
A
L
V
E
L
H
G
G
W
V
A
L
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
-------
E
T
Q
-----------------------
12
PsiBlast_PDB
68.69
31%
-88
- C2 -
4BIY
3
CPXA_ECOLI
A:
[75-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
----------------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
-
G
-----
E
-
S
K
E
L
----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
T
-
I
K
A
N
Q
L
W
S
E
V
L
D
--
N
A
A
F
E
A
E
Q
M
-----
G
K
S
L
------
T
V
N
F
P
P
-
G
-
P
W
P
L
Y
-
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
V
--
G
F
A
V
D
---
K
--
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
---------
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---------------------------------
32
PsiBlast_CBE
68.38
31%
-81
- C2 -
4BIW
2
CPXA_ECOLI
B:
[75-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
----------------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
-
G
-----
E
-
S
K
E
L
----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
T
-
I
K
A
N
Q
L
W
S
E
V
L
D
--
N
A
A
F
E
A
E
Q
M
-----
G
K
S
L
------
T
V
N
F
P
P
-
G
-
P
W
P
L
Y
-
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
V
--
G
F
A
V
D
---
K
--
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---------------------------------
16
PsiBlast_PDB
68.24
30%
-79
- C2 -
4CB0
6
CPXA_ECOLI
A:
[75-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
----------------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
-
G
-----
E
-
S
K
E
L
----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
T
-
I
K
A
N
Q
L
W
S
E
V
L
D
--
N
A
A
F
E
A
E
Q
M
-----
G
K
S
L
------
T
V
N
F
P
P
-
G
-
P
W
P
L
Y
-
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
V
--
G
F
A
V
D
---
K
--
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---------------------------------
29
PsiBlast_CBE
66.34
31%
-84
- C2 -
4BIY
4
CPXA_ECOLI
C:
[75-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
----------------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
-
G
-----
E
-
S
K
E
L
----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
T
-
I
K
A
N
Q
L
W
S
E
V
L
D
--
N
A
A
F
E
A
E
Q
M
-----
G
K
S
L
------
T
V
N
F
P
P
-
G
-
P
W
P
L
Y
-
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
V
--
G
F
A
V
D
---
K
--
D
G
--
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
---------
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---------------------------------
72
HHSearch
58.65
39%
-83
- C2 -
3SL2
2
A:
[3-153]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
I
V
R
F
M
S
L
I
I
D
--
R
F
E
M
T
-
K
E
Q
-------
E
F
------
I
R
N
-
L
P
D
R
-
D
L
Y
V
E
-
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
G
---
H
V
--
T
F
S
I
D
---
V
NE
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
E
------------------------------
17
PsiBlast_PDB
44.79
44%
-71
- C2 -
3SL2
2
A:
[27-150]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------
R
N
L
-
P
D
-
R
-
D
L
Y
V
E
-
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
G
---
H
V
T
F
S
I
D
V
N
---
E
--
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
---------------------------------