@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0819: (2016-04-26 )
MTALDWRSALTADEQRSVRALVTATTAVDGVAPVGEQVLRELGQQRTEHLLVAGSRPGGPIIGYLNLSPPRGAGGAMAELVVHPQSRRRGIGTAMARAALAKTAGRNQFWAHGTLDPARATASALGLVGVRELIQMRRPLRDIPEPTIPDGVVIRTYAGTSDDAELLRVNNAAFAGHPEQGGWTAVQLAERRGEAWFDPDGLILAFGDSPRERPGRLLGFHWTKVHPDHPGLGEVYVLGVDPAAQRRGLGQMLTSIGIVSLARRLGGRKTLDPAVEPAVLLYVESDNVAAVRTYQSLGFTTYSVDTAYALAGTDN
Atome Classification :
(20 SA)
-----.........10---.---....---...20........30--.----.-..-...-.40....----.----.----..50........60........70------.------------------------..-......80........90........100..-----------.----------..---..---110----------.---.------------.......120..---------.....130-----...-.-----....140-----..-.-.-..------...150.-..-..-..160.......170.......--180.-.---..-...190---...----...------.--.200-----.........210.......220..-...----------------.-----------------------------.------230......-.240....-------------...250.......260...--....270.......280...-....290.......300.......310...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----MTAL
D
W
R
S
ALT---
A
---
D
E
Q
R
---
S
V
R
A
L
V
T
A
TTAVDGV--A----
P
-
V
G
-
E
Q
V
-
L
R
E
L
G
Q
Q
----
R
----
T
----
E
H
L
L
V
AGSRPGG
P
I
I
G
Y
L
NLSPP-------R------------------------GA-GG
A
M
A
E
L
V
VH
P
Q
S
RRR
G
I
G
T
A
M
A
R
A
A
L
A
KTA-----------G----------RN---
Q
F
---
W
------------A---H------------GTL
D
P
A
R
A
T
A
S
A
---------
L
G
L
V
G
V
R
------
E
L
I
-
Q
-----
M
R
R
P
L
-------
R
D-I-P-EP------TIPD
G
V
V
-
I
R
-
T
Y-AGTSDDA
E
L
L
R
VNNAAFAGHPE--QGG
W
-
T
---
A
V
-
Q
L
A
E
R----RGE----AWF------D--PD-------
G
L
I
L
AFGDSPRERPG
R
L
L
G
F
H
W
T
K-VHP----------------D-----------------------------H------PGL
G
E
V
Y
V
L
-GV
D
P
A
A
Q
R
-------------
R
G
L
G
Q
M
L
T
S
I
G
I
V
S
L
A
R
R
L--GGRKTLDPAVE
P
A
V
L
L
Y
VES-DN
V
A
A
V
R
T
Y
Q
SLG
F
T
T
Y
SVD
T
A
Y
A
LAGTDN
3
PsiBlast_PDB
98.09
100%
-111
- C1 -
1P0H
2
MSHD_MYCTU
A:
[6-313]
-------
A
L
D
W
R
S
A
L
T
---
A
---
D
E
Q
R
---
S
V
R
A
L
V
T
A
T
T
A
V
D
G
V
--
A
----
P
-
V
G
-
E
Q
V
-
L
R
E
L
G
Q
Q
----
R
----
T
----
E
H
L
L
V
A
G
S
R
P
G
G
P
I
I
G
Y
L
N
L
S
P
P
-----------------------------------
G
G
A
M
A
E
L
V
V
H
P
Q
S
R
R
R
G
I
G
T
A
M
A
R
A
A
L
A
K
T
A
-----------
G
----------
R
N
---
Q
F
---
W
------------
A
---
H
------------
G
T
L
D
P
A
R
A
T
A
S
A
---------
L
G
L
V
G
V
R
------
E
L
I
-
Q
-----
M
R
R
P
L
-------
R
D
-
I
-
P
-
E
P
------
T
I
P
D
G
V
V
-
I
R
-
T
Y
-
A
G
T
S
D
D
A
E
L
L
R
V
N
N
A
A
F
A
G
H
P
E
--
Q
G
G
W
-
T
---
A
V
-
Q
L
A
E
R
----
R
G
E
----
A
W
F
------
D
--
P
D
-------
G
L
I
L
A
F
G
D
------
G
R
L
L
G
F
H
W
T
K
-
V
H
P
----------------
D
-----------------------------
H
------
P
G
L
G
E
V
Y
V
L
-
G
V
D
P
A
A
Q
R
-------------
R
G
L
G
Q
M
L
T
S
I
G
I
V
S
L
A
R
R
L
-----------
V
E
P
A
V
L
L
Y
V
E
S
-
D
N
V
A
A
V
R
T
Y
Q
S
L
G
F
T
T
Y
S
V
D
T
A
Y
A
L
-----
2
PsiBlast_PDB
97.73
100%
-112
- C1 -
1OZP
2
MSHD_MYCTU
A:
[6-313]
-------
A
L
D
W
R
S
A
L
T
---
A
---
D
E
Q
R
---
S
V
R
A
L
V
T
A
T
T
A
V
D
G
V
--
A
----
P
-
V
G
-
E
Q
V
-
L
R
E
L
G
Q
Q
----
R
----
T
----
E
H
L
L
V
A
G
S
R
P
G
G
P
I
I
G
Y
L
N
L
S
P
P
-----------------------------------
G
G
A
M
A
E
L
V
V
H
P
Q
S
R
R
R
G
I
G
T
A
M
A
R
A
A
L
A
K
T
A
-----------
G
----------
R
N
---
Q
F
---
W
------------
A
---
H
------------
G
T
L
D
P
A
R
A
T
A
S
A
---------
L
G
L
V
G
V
R
------
E
L
I
-
Q
-----
M
R
R
P
L
-------
R
D
-
I
-
P
-
E
P
------
T
I
P
D
G
V
V
-
I
R
-
T
Y
-
A
G
T
S
D
D
A
E
L
L
R
V
N
N
A
A
F
A
G
H
P
E
--
Q
G
G
W
-
T
---
A
V
-
Q
L
A
E
R
----
R
G
E
----
A
W
F
------
D
--
P
D
-------
G
L
I
L
A
F
G
D
------
G
R
L
L
G
F
H
W
T
K
-
V
H
P
----------------
D
-----------------------------
H
------
P
G
L
G
E
V
Y
V
L
-
G
V
D
P
A
A
Q
R
-------------
R
G
L
G
Q
M
L
T
S
I
G
I
V
S
L
A
R
R
L
-----------
V
E
P
A
V
L
L
Y
V
E
S
-
D
N
V
A
A
V
R
T
Y
Q
S
L
G
F
T
T
Y
S
V
D
T
A
Y
A
L
-----
53
Fugue
97.70
99%
-109
- C1 -
1P0H
2
MSHD_MYCTU
A:
[6-313]
-------
A
L
D
W
R
S
A
L
T
---
A
---
D
E
Q
R
---
S
V
R
A
L
V
T
A
T
T
A
V
D
G
V
--
A
----
P
-
V
G
-
E
Q
V
-
L
R
E
L
G
Q
Q
----
R
----
T
----
E
H
L
L
V
A
G
S
R
P
G
G
P
I
I
G
Y
L
N
L
S
P
P
-------
G
------------------------
G
A
----
M
A
E
L
V
V
H
P
Q
S
R
R
R
G
I
G
T
A
M
A
R
A
A
L
A
K
T
A
-----------
G
----------
R
N
---
Q
F
---
W
------------
A
---
H
------------
G
T
L
D
P
A
R
A
T
A
S
A
---------
L
G
L
V
G
V
R
------
E
L
I
-
Q
-----
M
R
R
P
L
-------
R
D
-
I
-
P
-
E
P
------
T
I
P
D
G
V
V
-
I
R
-
T
Y
-
A
G
T
S
D
D
A
E
L
L
R
V
N
N
A
A
F
A
G
H
P
E
--
Q
G
G
W
-
T
---
A
V
-
Q
L
A
E
R
----
R
G
E
----
A
W
F
------
D
--
P
D
-------
G
L
I
L
A
F
G
D
------
G
R
L
L
G
F
H
W
T
K
-
V
H
P
----------------
D
-----------------------------
H
------
P
G
L
G
E
V
Y
V
L
-
G
V
D
P
A
A
Q
R
-------------
R
G
L
G
Q
M
L
T
S
I
G
I
V
S
L
A
R
R
-----------
L
V
E
P
A
V
L
L
Y
V
E
S
-
D
N
V
A
A
V
R
T
Y
Q
S
L
G
F
T
T
Y
S
V
D
T
A
Y
A
L
-----
31
HHSearch
96.50
98%
-110
- C1 -
1P0H
2
MSHD_MYCTU
A:
[6-313]
-------
A
L
D
W
R
S
A
L
T
---
A
---
D
E
Q
R
---
S
V
R
A
L
V
T
A
T
T
A
V
D
G
V
--
A
----
P
-
V
G
-
E
Q
V
-
L
R
E
L
G
Q
Q
----
R
----
T
E
---
H
L
L
V
A
G
S
R
-
P
G
G
P
I
I
G
Y
L
N
L
S
P
P
-----------------------------------
G
G
A
M
A
E
L
V
V
H
P
Q
S
R
R
R
G
I
G
T
A
M
A
R
A
A
L
A
K
T
A
-----------
G
----------
R
N
---
Q
F
---
W
------------
A
---
H
------------
G
T
L
D
P
A
R
A
T
A
S
A
---------
L
G
L
V
G
V
R
------
E
L
I
-
Q
-----
M
R
R
P
L
-------
R
D
-
I
-
P
-
E
P
------
T
I
P
D
G
V
V
-
I
R
-
T
Y
-
A
G
T
S
D
D
A
E
L
L
R
V
N
N
A
A
F
A
G
H
P
E
--
Q
G
G
W
-
T
---
A
V
-
Q
L
A
E
R
----
R
G
E
----
A
W
F
------
D
--
P
D
-------
G
L
I
L
A
F
G
D
------
G
R
L
L
G
F
H
W
T
K
-
V
H
P
----------------
D
-----------------------------
H
------
P
G
L
G
E
V
Y
V
L
-
G
V
D
P
A
A
Q
R
-------------
R
G
L
G
Q
M
L
T
S
I
G
I
V
S
L
A
R
R
L
-----------
V
E
P
A
V
L
L
Y
V
E
S
-
D
N
V
A
A
V
R
T
Y
Q
S
L
G
F
T
T
Y
S
V
D
T
A
Y
A
L
-----
1
PsiBlast_PDB
95.22
100%
-86
- C- -
2C27
3
MSHD_MYCTU
A:
[5-312]
---------
D
W
R
S
A
L
T
---
A
---
D
E
Q
R
---
S
V
R
A
L
V
T
A
T
T
A
V
D
G
V
--
A
----
P
-
V
G
-
E
Q
V
-
L
R
E
L
G
Q
Q
----
R
----
T
----
E
H
L
L
V
A
G
S
---
G
P
I
I
G
Y
L
N
L
S
P
P
-------
R
------------------------
G
A
-
G
G
A
M
A
E
L
V
V
H
P
Q
S
R
R
R
G
I
G
T
A
M
A
R
A
A
L
A
K
T
A
-----------
G
----------
R
N
---
Q
F
---
W
------------
A
---
H
------------
G
T
L
D
P
A
R
A
T
A
S
A
---------
L
G
L
V
G
V
R
------
E
L
I
-
Q
-----
M
R
R
P
L
-------
R
D
-
I
-
P
-
E
P
------
T
I
P
D
G
V
V
-
I
R
-
T
Y
-
A
G
T
S
D
D
A
E
L
L
R
V
N
N
A
A
F
A
G
H
P
E
--
Q
G
G
W
-
T
---
A
V
-
Q
L
A
E
R
----
R
G
E
----
A
W
F
------
D
--
P
D
-------
G
L
I
L
A
F
G
D
S
P
R
E
R
P
G
R
L
L
G
F
H
W
T
K
-
V
H
P
----------------
D
-----------------------------
H
------
P
G
L
G
E
V
Y
V
L
-
G
V
D
P
A
A
Q
R
-------------
R
G
L
G
Q
M
L
T
S
I
G
I
V
S
L
A
R
R
L
-----
K
T
L
D
P
A
V
E
P
A
V
L
L
Y
V
E
S
-
D
N
V
A
A
V
R
T
Y
Q
S
L
G
F
T
T
Y
S
V
D
T
A
Y
A
L
A
G
---
32
HHSearch
63.48
22%
-86
* C1 *
3TT2
13
?
A:
[10-318]
-----
P
D
R
F
I
A
R
A
-
P
V
---
P
---
A
D
A
P
---
A
I
A
R
L
I
A
A
C
Q
E
A
D
G
D
--
E
----
P
D
A
S
A
E
E
V
-
L
R
D
W
E
G
L
DLG-
Q
----
E
----
A
V
L
V
V
A
---
P
D
G
E
A
A
A
Y
A
D
V
L
N
--------
R
------------------------
R
Y
-
V
Q
L
S
V
Y
G
Y
V
H
P
R
F
R
G
M
G
L
G
T
W
L
V
Q
W
G
E
E
W
I
Q
D
----------
R
MHLAPAE
A
Q
V
T
V
---
Q
H
---
Y
------------
I
---
R
------------
A
S
S
T
S
A
L
R
L
M
E
Q
---------
H
G
Y
R
P
V
R
------
D
I
W
-
V
-----
M
A
I
T
L
-------
D
Q
-
P
-
P
P
A
P
------
E
W
P
E
G
I
T
-
A
R
-
T
F
-
V
P
G
L
D
E
R
A
T
Y
E
A
V
E
E
A
F
G
------
R
P
P
S
-
T
---
F
E
-
R
W
L
S
M
----
T
Q
S
----
E
R
K
------
D
--
P
E
-------
L
W
L
L
A
V
E
T
D
----
S
G
H
I
V
G
T
C
L
G
Q
-
E
T
------------------------------------------------------
A
G
K
G
W
I
G
S
V
-
G
V
R
R
P
W
R
G
-------------
R
G
I
A
L
A
L
L
Q
E
V
F
G
V
Y
Y
-
R
R
--
G
---------
V
R
E
V
E
L
S
V
D
A
E
S
R
T
G
A
P
R
L
Y
R
R
A
G
M
H
V
K
H
R
Y
V
L
H
R
K
E
I
R
--
36
HHSearch
57.50
19%
-79
- C1 -
4ZM6
2
?
A:
[547-857]
-------------------
D
---
D
D
L
D
---
H
V
T
A
M
W
D
D
I
F
G
K
D
W
--------
P
-
L
R
K
D
K
I
-
N
L
G
L
Q
R
A
K---
L
----
Q
----
K
H
K
V
A
R
D
--
S
Q
G
K
I
V
G
F
V
A
T
Q
I
V
V
V
D----
N
------------------------
K
K
-
H
G
Q
L
M
L
L
M
V
S
P
S
Y
Q
G
K
G
V
G
T
L
L
H
D
A
A
L
E
H
F
R
E
Q
GA-------
D
----------
C
I
---
K
L
---
G
------------
S
---
T
YPRFFPGVPDDD
A
Q
S
R
K
A
Q
A
F
F
S
K
---------
K
G
W
R
M
D
D
------
N
L
V
H
D
-----
L
I
G
D
L
-------
Q
D
-
Y
-
K
-
V
P
D
K
I
Q
A
R
M
L
K
E
K
I
W
-
F
G
-
R
I
-
K
P
S
-
E
T
W
E
L
Y
A
F
Q
Q
R
N
F
P
H
--------
W
-----
L
S
-
T
Y
Q
H
H
----
V
E
L
----
G
--------
D
--
Y
Q
-------
D
L
I
V
A
R
Q
D
D
---
E
N
G
R
V
I
A
S
L
I
L
N
-
T
T
H
VSHEYRSDLIWTDDKL
F
-----------------------------
G
------
E
R
S
G
G
M
A
C
V
-
G
V
A
Q
E
E
R
G
-------------
R
G
I
G
I
G
I
V
A
H
A
N
W
L
L
K
-
Q
R
--
G
---------
V
T
K
S
Y
V
D
W
V
-----
E
L
L
D
F
Y
S
R
V
G
Y
K
T
W
R
S
Y
R
L
G
H
------
33
HHSearch
56.20
18%
-76
- C1 -
2WPX
2
?
A:
[6-337]
------
G
E
L
E
F
V
P
-
L
A
---
A
---
N
D
D
E
T
V
G
Q
W
L
D
L
M
A
L
A
A
E
T
G
P
R
AA
P
----
P
-
C
N
-
V
D
M
-
V
G
S
L
R
F
A
PPA
T
A
----
L
----
D
D
W
V
V
R
S
---
G
G
R
V
V
G
A
L
R
L
A
L
P
-------
D
G-----------------------
A
P
-
T
A
R
V
D
Q
L
L
V
H
P
G
R
R
R
R
G
I
G
R
A
L
W
A
H
A
R
E
L
A
R
K
H
DR-------
T
----------
T
L
---
T
A
---
T
------------
V
---
V
E
S
L
PSGP-----
A
Q
D
P
G
P
A
A
F
A
A
A
---------
M
G
A
H
R
S
D
I
P
A
G
T
H
Q
W
L
-
D
-----
L
D
R
H
D
-------
P
L
-
A
D
G
-
V
P
------
A
V
P
A
G
Y
S
-
L
V
-
T
W
-
G
T
I
-
T
P
D
E
Y
A
V
P
V
S
E
L
E
L
---------
R
-
A
---
A
Q
-
E
V
R
T
S
Y
A
R
Q
F
E
T
M
R
V
-
G
R
G
------
R
--
R
A
-------
Y
H
T
G
A
V
H
D
----
A
T
G
A
L
A
G
Y
T
S
V
S
-
K
T
T
----------------
G
-----------------------------
N
------
P
A
Y
A
L
Q
G
M
T
-
V
V
H
R
E
H
R
G
-------------
H
A
L
G
T
L
L
K
L
A
N
L
E
Y
V
L
-
R
H
E
P
E
---------
V
R
L
V
E
T
A
N
A
E
-
D
N
H
P
M
I
A
V
N
A
A
L
G
F
E
P
Y
D
R
W
V
F
W
T
A
E
A
G
P
-
54
Fugue
50.90
19%
-52
- C1 -
2WPX
2
?
A:
[5-338]
A
G
E
L
E
F
V
P
L
A
A
N
D
D
E
T
---
V
---
G
Q
W
L
---
D
L
M
A
L
A
A
E
T
G
P
R
A
A
P
--
P
----
C
-
N
V
-
D
M
V
-
G
S
L
R
F
A
P
----
P
----
A
----
T
A
L
D
D
W
V
V
R
S
G
G
R
V
V
G
A
L
R
L
A
L
P
-------
D
------------------------
G
A
P
T
A
R
V
D
Q
L
L
V
H
P
G
R
R
R
R
G
I
G
R
A
L
W
A
H
A
R
E
L
A
R
K
H
DRT
T
L
T
A
T
V
V
----------
E
S
---
L
P
---
S
------------
G
---
P
------------
A
Q
D
P
G
P
A
A
F
A
A
A
---------
M
G
A
H
R
S
D
------
I
P
A
-
G
-----
T
H
Q
W
L
D
LDRHDP
L
A
-
D
-
G
-
V
P
------
A
V
P
A
G
Y
S
-
L
V
-
T
W
-
G
T
I
T
P
D
E
Y
A
V
P
V
S
E
L
E
L
R
A
A
Q
E
--
V
R
T
S
-
Y
---
A
R
-
Q
F
E
T
M
----
R
V
G
----
R
G
R
------
R
--
A
Y
-------
H
T
G
A
V
H
D
A
T
-----
G
A
L
A
G
Y
T
S
V
S
-
K
T
T
----------------
G
-----------------------------
N
------
P
A
Y
A
L
Q
G
M
T
-
V
V
H
R
E
H
R
G
-------------
H
A
L
G
T
L
L
K
L
A
N
L
E
Y
V
L
R
H
E
--
P
E
V
R
--------
L
V
E
T
A
N
A
E
-
D
N
H
P
M
I
A
V
N
A
A
L
G
F
E
P
Y
D
R
W
V
F
W
T
A
E
A
G
P
S
35
HHSearch
46.62
14%
-54
- C1 -
4C7I
5
?
A:
[44-392]
------
S
T
F
E
W
W
T
-
P
N
MEA
A
---
D
D
I
H
---
A
I
Y
E
L
L
R
D
N
Y
V
E
D
D
D
--
S
MFRF
N
-
Y
S
-
E
E
F
-
L
Q
W
A
L
C
P
----
P
----
N
YIPD
W
H
V
A
V
R
R
K
-
A
D
K
K
L
L
A
F
I
A
G
V
P
V
T
L
RM---
G
TP
K
Y
M
K
V
K
A
Q
E
K
GE
G
E
E
A
A
K
YDEP
R
H
-
I
C
E
I
N
F
L
C
V
H
K
Q
L
R
E
K
R
L
A
P
I
L
I
K
E
A
T
R
R
V
N
R
----------
T
----------
N
V
W--
Q
A
V
Y
-
T
A
GVLLPTPY
A
S
G
Q
---
Y
------------
F
H
R
S
L
N
P
E
K
L
V
E
---------
I
R
F
S
G
I
P
------
A
Q
Y
-
Q
KFQN
P
M
A
M
L
K
-------
R
N
-
Y
-
Q
-
L
P
------
S
A
P
K
N
S
G
-
L
R
-
E
M
-
K
P
S
-
D
V
P
Q
V
R
R
I
L
M
N
Y
L
D
S
F
D
V
--
G
P
V
F
-
S
---
D
A
-
E
I
S
H
Y
----
L
L
-----
P
R
D
------
G
--
V
V
-------
F
T
Y
V
V
E
N
------
D
K
K
V
T
D
F
F
S
F
Y
-
R
I
P
----------------
S
T
VI--------------------------
G
NSNYN
L
L
N
A
A
Y
V
H
Y
Y
-
A
A
T
----
S
-------------
I
P
L
H
Q
-
L
I
L
D
L
L
I
V
A
H
-
S
R
--
G
---------
F
D
V
C
N
M
V
E
I
L
-
D
N
R
---
S
F
V
E
Q
L
K
F
G
A
G
D
G
H
L
R
Y
Y
------
62
Fugue
45.40
15%
-58
- C1 -
2FT0
1
WECD_ECOL6
A:
[14-235]
---------------------------------------------------------
V
R
A
-
S
I
E
P
L
T
W
----
E
----
N
----
A
F
F
-------------------------------------------------------
G
V
N
S
A
I
V
R
I
T
S
E
A
P
L
-------
L
T
P
D
A
L
A
P
W
-----------
S
----------
R
V
---
Q
A
---
K
------------
I
---
A
------------
A
S
N
T
G
E
L
D
A
L
Q
Q
---------
L
G
F
S
L
V
E
------
G
E
V
-
D
-----
L
A
L
P
V
-------
N
N
-
V
-
S
-
D
S
------
G
A
---------
V
V
-
A
Q
E
T
D
I
P
A
L
R
Q
L
A
S
A
A
F
A
Q
S
R
F
--
R
A
P
W
-
Y
---
A
P
-
D
A
S
G
R
----
F
Y
A
----
Q
W
I
------
E
--
N
A
V
R
GTFD
H
Q
C
L
I
L
R
-----
A
A
S
G
D
I
R
G
Y
V
S
L
R
-
E
L
N
----------------
A
-----------------------------
T
--------------
D
-
A
R
I
G
L
L
A
G
-------------
R
G
A
G
A
E
L
M
Q
T
-
A
L
N
W
A
Y
A
R
--
G
---------
K
T
T
L
R
V
A
T
Q
M
-
G
N
T
A
A
L
K
R
Y
I
Q
S
G
A
N
V
E
S
T
A
Y
W
L
Y
R
-----
49
HHSearch
45.24
17%
-68
- C1 -
2FT0
1
WECD_ECOL6
A:
[54-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
---
Q
A
---
K
------------
I
---
A
------------
A
S
N
T
G
E
L
D
A
L
Q
Q
---------
L
G
F
S
L
V
E
------
G
E
V
-
D
-----
L
A
L
P
V
-------
N
N
-
V
-
S
-------------
D
S
G
-
A
V
-
V
A
-
Q
E
T
-
D
I
P
A
L
R
Q
L
A
S
A
A
F
A
Q
S
R
F
--
R
A
P
W
Y
A
PD
A
S
G
R
F
Y
A
Q
W
----
I
E
N
----
A
V
R
------
G
TF
D
H
-------
Q
C
L
I
L
R
A
A
-----
S
G
D
I
R
G
Y
V
S
L
R
-
E
L
N
-----------------------------------------------------
A
T
---
D
A
R
I
-
G
L
L
---
A
G
-------------
R
G
A
G
A
E
L
M
Q
T
A
L
N
W
A
Y
-
A
R
--
G
---------
K
T
T
L
R
V
A
T
Q
M
-
G
N
T
A
A
L
K
R
Y
I
Q
S
G
A
N
V
E
S
T
A
Y
W
--------
51
HHSearch
44.26
16%
-85
- C1 -
4EVY
5
AAC6_ACIHA
A:
[20-166]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
M
N
-
I
K
-
P
A
-
S
E
A
-
S
L
K
D
W
L
E
L
R
N
K
L
W
S
D
S
E
A
--
S
----
H
---
L
Q
-
E
M
H
Q
L
----
L
A
E
----
K
-----------
Y
A
-------
L
Q
L
L
A
Y
S
------
D
H
Q
A
I
A
M
L
E
A
S
-
I
R
F
----------------
E
YVNGTE-----------------------
T
------
S
P
V
G
F
L
E
G
I
-
Y
V
L
P
A
H
R
R
-------------
S
G
V
A
T
M
L
I
R
Q
A
E
V
W
A
K
-
Q
F
--
S
---------
C
T
E
F
A
S
D
A
A
L
-
D
N
V
I
S
H
A
M
H
R
S
L
G
F
Q
E
T
E
K
V
V
Y
F
S
K
K
I
D
--
52
HHSearch
44.11
19%
-61
- C1 -
1U6M
2
?
A:
[3-175]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
I
R
-
S
A
-
T
K
E
-
D
G
Q
A
I
A
R
L
V
L
V
I
L
K
D
M
E
L
P
I
L
E
E
V
-
S
---
E
E
-
Q
M
I
D
L
----
L
A
E
A
T
A
Y
P
T
Y
------
R
YG
Y
Q
-------
R
I
L
V
Y
E
H
------
A
G
E
V
A
G
I
A
V
G
Y
-
P
A
E
----------------
D
EKIID
E
P
L
R
E
V
F
K
K
H
GLAEDVRLFIEEET
L
------
P
N
E
W
Y
L
D
T
I
-
S
V
D
E
R
F
R
G
-------------
M
G
I
G
S
K
L
L
D
A
L
P
E
V
A
K
-
A
S
--
G
---------
K
Q
A
L
G
L
N
V
D
F
-
D
N
P
G
A
R
K
L
Y
A
S
K
G
F
K
D
V
T
T
M
----------
41
HHSearch
43.41
11%
-59
- C1 -
1IIC
1
NMT_YEAST
A:
[44-388]
------
S
S
F
E
W
C
S
-
I
D
---
V
DN
K
K
Q
L
E
---
D
V
F
V
L
L
N
E
N
Y
V
E
D
R
D
--
A
G
F
R
F
N
-
Y
T
-
K
E
F
-
F
N
W
A
L
K
S
----
P
GWKK
D
----
W
H
I
G
V
R
V
K
-
E
T
Q
K
L
V
A
F
I
S
A
I
P
V
T
L
G
V
RGK
Q
------------------------
V
P
-
S
V
E
I
N
F
L
C
V
H
K
Q
L
R
S
K
R
L
T
P
V
L
I
K
E
I
T
R
R
V
N
K
----------
C
----------
D
I
W
H
A
L
Y
---
T
A
GI---------
V
---
L
------------
P
A
P
V
S
T
C
R
Y
T
H
R
P
LN
W
K
K
L
Y
E
V
D
F
T
G
L
P
------
D
G
H
-
T
-----
E
E
D
M
I
-------
A
E
-
N
-
A
-
L
P
------
A
K
T
K
T
A
G
-
L
R
-
K
L
-
K
K
E
-
D
I
D
Q
V
F
E
L
F
K
R
Y
Q
S
R
F
E
L
--
I
Q
I
F
-
T
---
K
E
-
E
F
E
H
N
----
F
I
G
-----
E
E
SLPLDK
Q
--
V
I
-------
F
S
Y
V
V
E
Q
P
-----
D
G
K
I
T
D
F
F
S
F
Y
S
L
P
F
----------------
T
I
L
NNTKYK---------------------
D
------
L
G
I
G
Y
L
Y
Y
Y
-
A
T
D
A
D
F
Q
F
KDRFD
P
K
A
T
K
A
L
K
T
R
L
-
C
E
L
I
Y
D
A
C
I
L
A
K
-
N
A
--
N
---------
M
D
V
F
N
A
L
T
S
Q
-
D
N
T
---
L
F
L
D
D
L
K
F
G
P
G
D
G
F
L
N
--------
43
HHSearch
43.38
18%
-87
- C1 -
2DXQ
5
?
A:
[4-143]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
I
S
-
L
R
-
A
A
-
G
P
G
-
D
L
P
G
L
L
E
L
Y
Q
V
L
N
P
S
D
P
E
-----
L
-
T
---
T
Q
-
E
A
G
A
V
----
F
A
A
----
M
L
A
------
Q
--
P
G
L
------
T
I
F
V
A
T
E
------
N
G
K
P
V
A
T
A
T
L
L
-
I
V
P
----------------
N
LTRA-------------------------
A
------
R
P
Y
A
F
I
E
N
V
-
V
T
L
E
A
R
R
G
-------------
R
G
Y
G
R
T
V
V
R
H
A
I
E
T
A
F
-
G
A
--
N
---------
C
Y
K
V
M
L
L
T
G
R
-
H
D
P
A
V
H
A
F
Y
E
S
C
G
F
V
Q
N
K
T
-----------
57
Fugue
43.23
13%
-51
- C1 -
3IWG
3
?
A:
[5-274]
--------------
F
K
---
I
---
K
T
I
E
---
S
L
S
D
L
T
Q
L
K
K
A
Y
F
D
S
--
S
----
I
-
V
P
-
L
D
G
M
W
H
F
G
F
A
P
M---
A
----
K
----
H
F
G
F
Y
V
N
----
K
N
L
V
G
F
C
C
V
N
D
D
------------------------------------
G
Y
L
L
Q
Y
Y
L
Q
P
E
F
Q
L
C
S
--
Q
E
L
F
T
L
I
S
Q
Q
N
S
-----------
S
----------
V
I
---
G
E
---
V
------------
K
---
G
------------
A
F
V
S
----
T
A
E
L
---------
N
Y
Q
A
L
C
L
------
D
N
S
-
A
-----
T
F
K
V
N
-------
S
L
M
Y
-
Q
-
H
N
------
T
K
L
A
N
L
E
M
I
D
M
Q
I
-
A
G
T
E
Q
L
T
A
F
V
T
F
A
A
A
N
I
-
G
A
P
E
--
Q
W
L
T
-
Q
---
Y
Y
-
G
N
L
I
E
----
R
K
E
----
L
F
G
------
Y
--
W
H
-------
K
-------------
G
K
L
L
A
A
G
E
C
R
-
L
F
D
----------------
Q
-----------------------------
Y
------
Q
T
-
E
Y
A
D
L
G
M
I
V
A
Q
S
N
R
G
-------------
Q
G
I
A
K
K
V
L
T
F
L
T
K
H
A
A
T
Q
-------------
G
L
T
S
I
C
S
T
E
S
-
N
N
V
A
A
Q
K
A
I
A
H
A
G
F
T
S
A
H
R
I
V
Q
F
E
F
K
----
44
HHSearch
43.00
11%
-47
- C1 -
4C68
8
?
A:
[43-362]
------
P
G
Y
S
W
Y
V
-
C
D
---
V
KD
E
K
D
R
S
---
E
I
Y
T
L
L
T
D
N
Y
V
E
D
D
D
--
N
IF
R
F
N
-
Y
S
-
A
E
F
-
L
L
W
A
L
T
S
----
P
NYLK
T
----
W
H
I
G
V
K
Y
D
-
A
S
N
K
L
I
G
F
I
S
A
I
P
T
D
I
C
I
HKR
T
------------------------
I
--
M
A
E
V
N
F
L
C
V
H
K
T
L
R
S
K
R
L
A
P
V
L
I
K
E
I
T
R
R
I
N
L
----------
E
----------
N
I
---
W
Q
A
I
Y
T
------------
A
GVY
L
------------
P
K
P
V
S
D
A
R
Y
Y
H
R
S
I
N
V
K
K
L
I
E
I
G
F
S
S
L
N
------
S
R
L
-
T
-----
M
S
R
A
I
-------
K
L
-
Y
-
R
-
V
E
------
D
T
L
N
I
K
N
-
M
R
-
L
M
-
K
K
K
-
D
V
E
G
V
H
K
L
L
G
S
Y
L
E
Q
F
N
L
--
Y
A
V
F
-
T
---
K
E
-
E
I
A
H
W
----
F
L
P
-----
I
E
------
N
--
V
I
-------
Y
T
Y
V
N
E
E
------
N
G
K
I
K
D
M
I
S
F
Y
-
S
L
P
----------------
S
Q
I
L
GNDKYS--------------------
T
------
L
N
A
A
Y
S
F
Y
N
-
V
----
T
T
T
-------------
A
T
F
-
K
Q
L
M
Q
D
A
I
L
L
A
K
-
R
N
--
N
---------
F
D
V
F
N
A
L
E
V
M
-
Q
N
K
---
S
V
F
E
D
L
K
F
G
E
G
D
G
S
L
---------
40
HHSearch
42.98
17%
-79
- C1 -
4IUS
3
?
A:
[85-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
P
G
L
A
Y
V
L
V
E
---------
H
G
M
T
I
V
S
------
R
P
P
-
L
-----
L
A
V
E
P
-------
G
D
-
L
-
L
-
V
P
------
E
F
P
A
G
V
T
-
A
A
-
V
V
A
S
A
E
-
E
Q
E
A
A
N
A
I
A
G
D
A
Y
E
T
D
-------------
A
S
-
P
F
Q
P
E
------------
P
A
---------
D
G
-------
G
A
V
L
I
R
M
------
D
G
V
P
V
A
T
A
A
W
T
-
A
I
A
-----------------------------------------------------
D
G
V
T
E
V
A
G
V
-
G
T
L
H
S
H
R
R
-------------
Q
G
L
G
A
L
A
T
A
Y
A
T
Q
Q
A
F
-
E
V
G-
G
---------
A
T
L
A
W
L
T
P
---
G
D
D
G
A
D
R
I
Y
R
R
L
G
Y
E
P
K
A
T
A
V
H
L
G
D
P
G
---
59
Fugue
42.88
15%
-57
- C1 -
1WWZ
2
?
A:
[1-157]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
E
I
K
I
E
-
K
L
-
K
K
-
L
D
K
K
A
L
N
E
L
I
D
V
Y
M
S
G
Y
E
G
L
E
E
--
Y
G
G
--
E
---
G
R
-
D
Y
A
R
N
----
Y
I
K
----
W
C
W
------
K
--
K
A
-------
S
D
G
F
F
V
A
K
V
G
D
K
I
V
G
F
I
V
C
D
K
D
W
F
-
S
K
Y
----------------
E
-----------------------------
G
------
R
I
V
G
A
I
H
E
F
-
V
V
D
K
K
F
Q
G
-------------
K
G
I
G
R
K
L
L
I
T
C
L
D
F
L
G
K
Y
N
-------------
D
T
I
E
L
W
V
G
E
-
K
N
Y
G
A
M
N
L
Y
E
K
F
G
F
K
K
V
G
K
S
G
I
W
V
R
M
I
K
R
Q