@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0933: (2016-04-27 )
MACERLGGQSGAADVDAAAPAMAAVNLTLGFAGKTVLDQVSMGFPARAVTSLMGPTGSGKTTFLRTLNRMNDKVSGYRYSGDVLLGGRSIFNYRDVLEFRRRVGMLFQRPNPFPMSIMDNVLAGVRAHKLVPRKEFRGVAQARLTEVGLWDAVKDRLSDSPFRLSGGQQQLLCLARTLAVNPEVLLLDEPTSALDPTTTEKIEEFIRSLADRLTVIIVTHNLAQAARISDRAALFFDGRLVEEGPTEQLFSSPKHAETARYVAGLSGDVKDAKRGN
Atome Classification :
(40 SA)
.........10........20........30..----..-....40........50........60........70---.........--80--.........90-...------------------.-.------------....100-........110..-.-....120...---------.....130........140.......150--........-160.......170.......180........190.......200-.......--210--.--.--......220.......230.....-..240.......250.......260...----------....270....-----------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
C
E
RLGGQSGAADVDAAAP
A
M
A
A
V
N
L
T
LGFA
G
----
K
T
-
V
L
D
Q
VSMGF
P
A
R
A
V
T
S
L
MGPTGSG
K
T
T
F
L
R
T
L
N
R
M----NDKVS
G
Y
R
Y--S---G
D
V
L
LGG
R
S
I--F
N
Y
------------------
R
-
D
------------
V
L
E
F
R
-
R
-
R
V
G
M
L
FQRPNPF
P
-
M
-
S
I
M
D
N
V
-
L
A
G
---------
V
R
A
HKL-V
P
R
K
E
F
R
G
V
A
Q
A
R
L
T
EVG
L
W
D
---
A
V
K
D
R
LSD-SPFRLSGG
Q
Q
Q
L
L
C
L
A
R
T
LAV-NP
E
V
L
L
LDEPTSALDPT
T
T
E
K
I
-
E
E
F
I
R
S
L
--A-D--R--
L
--
T
V
I
I
V
THN
L
A
Q
A
ARISD
R
A
A
L
F
FD-
G
R
LVEEG
P
T
E
Q
L
FSSPK
H
A
E
T
A
R
Y
V
AGL----------SGDVKDAKRGN-----------------------------------------------------------------------------------------------
91
Fugue
92.13
34%
-103
- C1 -
1B0U
4
HISP_SALTY
A:
[5-261]
-------------------
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
H---
E
V
-
L
K
-
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
EKPS-----------
E
---
G
A
I
I
V
N
G
------
Q
N
I
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
-
R
------------
L
L
R
T
--
R
--
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
-
T
V
L
E
N
V
-
M
E
A
---------
P
I
Q
V
L
-G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
---
R
A
Q
G
---
K
-
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
-
L
R
I
M
Q
Q
L
--
A
-
E
--
E
G-
K
--
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-
Q
--
S
P
R
L
Q
Q
F
L
----------
K
G
S
L
K
K
L
E
--------------------------------------------------------------------------------------------------
93
Fugue
91.32
31%
-97
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
-------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
GTRT
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
-
L
----
L
E
R
P
T
------
E
---
G
S
V
L
V
D
G
Q
E
L
TT
L
S
E
------------------
S
-
E
------------
L
T
K
A
R
-
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
-
S
-
R
T
V
F
G
N
-
V
A
L
---------
P
L
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-------
G
D
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
--
N
-
R
--
R
LG
L
--
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
LHLDIPEDYQ
E
R
L
Q
A
E
P
F
T
D
C
VPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV---------------------
3
PsiBlast_PDB
87.10
36%
-104
- C1 -
4YMS
-
?
J:
[11-239]
------------------------------
F
G
S
----
L
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
K
G
----------
E
V
F
I
D
G
V
K
I
--
N
N
G
------------------
K
V
N
------------
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
-
T
A
I
E
N
I
T
L
A
P
---------
V
K
V
K
K
M
--
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
---
K
-
K
D
Q
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
87.07
36%
-102
- C1 -
4YMU
2
?
A:
[11-239]
------------------------------
F
G
S
----
L
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
K
G
----------
E
V
F
I
D
G
V
K
I
--
N
N
G
------------------
K
V
N
------------
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
-
T
A
I
E
N
I
T
L
A
P
---------
V
K
V
K
K
M
--
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
---
K
-
K
D
Q
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.01
36%
-102
- C1 -
4YMV
1
?
J:
[11-239]
------------------------------
F
G
S
----
L
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
K
G
----------
E
V
F
I
D
G
V
K
I
--
N
N
G
------------------
K
V
N
------------
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
-
T
A
I
E
N
I
T
L
A
P
---------
V
K
V
K
K
M
--
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
---
K
-
K
D
Q
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.65
36%
-102
- C1 -
4YMT
-
?
J:
[11-239]
------------------------------
F
G
S
----
L
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
K
G
----------
E
V
F
I
D
G
V
K
I
--
N
N
G
------------------
K
V
N
------------
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
-
T
A
I
E
N
I
T
L
A
P
---------
V
K
V
K
K
M
--
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
---
K
-
K
D
Q
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------------------
98
Fugue
86.62
30%
-89
- C1 -
1Z47
1
?
A:
[11-355]
-----------------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
----
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
----
E
R
P
T
K
G
----------
D
V
W
I
G
G
K
R
V
-----------------------
T
-
D
------------
L
P
P
Q
K
-
R
-
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
-
T
V
Y
D
N
V
-
S
F
G
---------
L
R
E
K
R
--
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-------
E
S
Y
A
N
R
-
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
-
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
-
R
T
F
V
R
Q
V
--
H
-
D
--
E
--
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
-
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
----------
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
24
PsiBlast_CBE
86.39
36%
-99
- C1 -
4YMV
1
?
A:
[11-239]
------------------------------
F
G
S
----
L
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
K
G
----------
E
V
F
I
D
G
V
K
I
--
N
N
G
------------------
K
V
N
------------
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
-
T
A
I
E
N
I
T
L
A
P
---------
V
K
V
K
K
M
--
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
---
K
-
K
D
Q
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.34
36%
-96
- C1 -
4U02
1
?
A:
[3-238]
-------------------
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
-----
Q
--
E
---
G
E
V
V
V
D
G
L
S
V
--
K
D
D
------------------
R
-
A
------------
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
-
T
V
L
E
N
V
T
L
A
P
---------
M
R
V
R
R
W
--
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
---
Q
A
R
K
-----
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
--
A
-
Q
G-
G
--
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
-----------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
86.03
31%
-103
- C1 -
1B0U
4
HISP_SALTY
A:
[7-255]
---------------------
L
H
V
I
D
L
H
K
R
Y
G
G
----
H
E
-
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
-----
E
K
P
S
------
E
---
G
A
I
I
V
N
G
Q
N
I
--
N
L
V
------------------
R
-
D
KDGQLKVAD
K
N
Q
L
R
L
L
R
-
T
-
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
-
T
V
L
E
N
V
-
M
E
A
---------
P
I
Q
V
L
G
-
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
---
R
A
Q
G
K
Y
----
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
-
L
R
I
M
Q
Q
L
--
A
-
E
--
E
G-
K
--
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
---------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.66
36%
-98
- C1 -
4U00
3
?
A:
[3-238]
-------------------
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
-----
Q
--
E
---
G
E
V
V
V
D
G
L
S
V
--
K
D
D
------------------
R
-
A
------------
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
-
T
V
L
E
N
V
T
L
A
P
---------
M
R
V
R
R
W
--
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
---
Q
A
R
K
-----
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
--
A
-
Q
G
-
G
--
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
-----------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.60
36%
-100
- C1 -
4YMU
2
?
J:
[11-239]
------------------------------
F
G
S
----
L
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
K
G
----------
E
V
F
I
D
G
V
K
I
--
N
N
G
------------------
K
V
N
------------
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
-
T
A
I
E
N
I
T
L
A
P
---------
V
K
V
K
K
M
--
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
---
K
-
K
D
Q
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.52
36%
-95
- C1 -
4U02
1
?
C:
[3-238]
-------------------
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
-----
Q
--
E
---
G
E
V
V
V
D
G
L
S
V
--
K
D
D
------------------
R
-
A
------------
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
-
T
V
L
E
N
V
T
L
A
P
---------
M
R
V
R
R
W
--
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
---
Q
A
R
K
-----
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
--
A
-
Q
G-
G
--
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
-----------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
84.41
36%
-101
- C1 -
4YMW
-
?
J:
[11-239]
------------------------------
F
G
S
----
L
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
K
G
----------
E
V
F
I
D
G
V
K
I
--
N
N
G
------------------
K
V
N
------------
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
-
T
A
I
E
N
I
T
L
A
P
---------
V
K
V
K
K
M
--
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
---
K
-
K
D
Q
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.31
36%
-92
- C1 -
4U02
1
?
D:
[3-238]
-------------------
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
-----
Q
--
E
---
G
E
V
V
V
D
G
L
S
V
--
K
D
D
------------------
R
-
A
------------
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
-
T
V
L
E
N
V
T
L
A
P
---------
M
R
V
R
R
W
--
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
---
Q
A
R
K
-----
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
--
A
-
Q
G-
G
--
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
-----------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
83.25
36%
-95
- C1 -
4U02
1
?
B:
[3-238]
-------------------
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
-----
Q
--
E
---
G
E
V
V
V
D
G
L
S
V
--
K
D
D
------------------
R
-
A
------------
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
-
T
V
L
E
N
V
T
L
A
P
---------
M
R
V
R
R
W
--
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
---
Q
A
R
K
-----
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
--
A
-
Q
G-
G
--
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
-----------------------------------------------------------------------------------------------------------------------
81
HHSearch
80.49
33%
-97
* C1 *
3TUI
1
METN_ECOLI
C:
[23-256]
-------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
GTRT
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
----
E
R
P
T
-------
E
---
G
S
V
L
V
D
G
Q
E
L
--
T
T
L
SE----------------
S
-
E
------------
L
T
K
A
R
-
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
-
T
V
F
G
N
V
-
A
L
P
---------
L
E
L
D
N
T
-
P
-
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-------
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
--
N
-
R
RL
G
--
L
--
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
-------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
80.11
35%
-93
- C1 -
2OLK
1
?
D:
[29-260]
-------------------------
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-----
F
D
--
E
---
G
E
I
I
I
D
G
I
N
L
K-
A
K
D
------------------
T
-
N
------------
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
---------
M
K
V
R
K
W
--
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-------
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
79.56
35%
-93
- C1 -
2OLK
2
?
B:
[29-260]
-------------------------
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-----
F
D
--
E
---
G
E
I
I
I
D
G
I
N
L
K-
A
K
D
------------------
T
-
N
------------
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
---------
M
K
V
R
K
W
--
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-------
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
79.54
35%
-98
- C1 -
3C4J
4
?
B:
[29-260]
-------------------------
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-----
F
D
--
E
---
G
E
I
I
I
D
G
I
N
L
K-
A
K
D
------------------
T
-
N
------------
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
---------
M
K
V
R
K
W
--
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-------
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
79.50
35%
-95
- C1 -
2OLJ
4
?
A:
[29-260]
-------------------------
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-----
F
D
--
E
---
G
E
I
I
I
D
G
I
N
L
K-
A
K
D
------------------
T
-
N
------------
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
---------
M
K
V
R
K
W
--
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-------
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
79.36
35%
-95
- C1 -
2OLK
1
?
C:
[29-260]
-------------------------
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-----
F
D
--
E
---
G
E
I
I
I
D
G
I
N
L
K-
A
K
D
------------------
T
-
N
------------
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
---------
M
K
V
R
K
W
--
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-------
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.72
35%
-96
- C1 -
2OLK
1
?
A:
[29-260]
-------------------------
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-----
F
D
--
E
---
G
E
I
I
I
D
G
I
N
L
K-
A
K
D
------------------
T
-
N
------------
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
---------
M
K
V
R
K
W
--
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-------
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
78.59
35%
-91
- C1 -
3C41
3
?
J:
[8-239]
-------------------------
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-----
F
D
--
E
---
G
E
I
I
I
D
G
I
N
L
K-
A
K
D
------------------
T
-
N
------------
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
---------
M
K
V
R
K
W
--
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-------
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
78.14
35%
-97
- C1 -
3C41
3
?
K:
[8-239]
-------------------------
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-----
F
D
--
E
---
G
E
I
I
I
D
G
I
N
L
K-
A
K
D
------------------
T
-
N
------------
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
---------
M
K
V
R
K
W
--
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-------
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.16
35%
-84
- C1 -
3C4J
3
?
A:
[29-260]
-------------------------
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-----
F
D
--
E
---
G
E
I
I
I
D
G
I
N
L
K-
A
K
D
------------------
T
-
N
------------
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
---------
M
K
V
R
K
W
--
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-------
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.40
35%
-89
- C1 -
2Q0H
4
?
A:
[29-260]
-------------------------
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-----
F
D
--
E
---
G
E
I
I
I
D
G
I
N
L
K-
A
K
D
------------------
T
-
N
------------
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
---------
M
K
V
R
K
W
--
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-------
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
76.26
35%
-90
- C1 -
2OLJ
3
?
B:
[29-260]
-------------------------
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-----
F
D
--
E
---
G
E
I
I
I
D
G
I
N
L
K-
A
K
D
------------------
T
-
N
------------
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
---------
M
K
V
R
K
W
--
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-------
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
75.23
35%
-95
- C1 -
2Q0H
4
?
B:
[29-260]
-------------------------
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-----
F
D
--
E
---
G
E
I
I
I
D
G
I
N
L
K-
A
K
D
------------------
T
-
N
------------
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
---------
M
K
V
R
K
W
--
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-------
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
-
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
72.05
31%
-107
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-244]
--------------------
A
L
H
I
G
H
L
S
K
S
F
Q
N
----
T
P
-
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
-----------
A
G
F
E
Q
PD
S
---
G
E
I
S
L
S
G
K
T
I
--
F
S
K
------------------
N
-
T
------------
N
L
P
V
R
E
R
-
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
-
T
V
Y
R
N
I
-
A
Y
G
---------
L
G
N
G
K
G
-
R
T
A
Q
E
-
R
Q
R
I
E
A
M
L
E
L
T
G
-------
I
S
E
L
A
G
R
-
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
-
N
--
G
--
K
--
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
-----------------------------------------------------------------------------------------------------------------------
75
HHSearch
64.60
32%
-95
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[3-236]
-------------------
A
A
L
H
I
G
H
L
S
K
S
F
Q
N
----
T
P
-
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
----
E
Q
P
D
-------
S
---
G
E
I
S
L
S
G
K
T
I
--
F
S
K
N-----------------
T
-
N
------------
L
P
V
R
E
-
R
-
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
-
T
V
Y
R
N
I
-
A
Y
G
---------
L
G
N
G
K
G
-
R
-
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
-------
L
A
G
R
-
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
-
R
E
D
M
I
A
A
--
L
R
A
N
-
G
--
K
--
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
-------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
63.64
31%
-96
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[359-573]
----------------------------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
----
Y
D
P
A
S
G
----------
T
I
S
L
D
G
H
D
I
--
R
Q
L
------------------
N
-
P
------------
V
W
-
L
R
-
S
-
K
I
G
T
V
S
Q
E
P
I
L
F
S
-
C
-
S
I
A
E
N
I
-
A
Y
G
---------
A
D
D
P
S
S
-
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
FPQ
G
F
N
T
V
V
G
E
-
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
--
M
-
D
--
G
--
R
--
T
V
L
V
I
A
H
R
L
S
-
T
I
K
N
A
N
M
V
A
V
L
D
Q
-
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
-------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
60.49
31%
-93
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[359-567]
----------------------------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
----
Y
D
P
A
S
G
----------
T
I
S
L
D
G
H
D
I
--
R
Q
L
------------------
N
-
P
------------
V
W
-
L
R
-
S
-
K
I
G
T
V
S
Q
E
P
I
L
F
S
-
C
-
S
I
A
E
N
I
-
A
Y
G
---------
A
D
D
P
S
S
-
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
FPQ
G
F
N
T
V
V
G
E
-
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
--
M
-
D
--
G
--
R
--
T
V
L
V
I
A
H
R
L
S
-
T
I
K
N
A
N
M
V
A
V
L
D
Q
-
G
K
I
T
E
Y
G
K
H
E
E
-------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
59.72
31%
-84
- C1 -
1L2T
4
Y796_METJA
B:
[21-226]
-----------------------------------------
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
----
D
K
P
T
E
G
E
V
Y
--
I
---
D
N
I
K
T
N
D
-----
L
D
D
------------------
D
-
E
------------
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-
L
L
T
A
L
E
N
V
E
L
P
L
---------
I
F
K
Y
R
G
-
A
M
S
G
E
E
R
---
R
K
R
A
L
E
C
L
K
M
A
---
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
-
M
Q
L
L
K
K
L
NE
E
-
D
--
G
--
K
--
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
E
R
E
------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
59.59
31%
-101
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[390-598]
----------------------------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
----
Y
D
P
A
S
G
----------
T
I
S
L
D
G
H
D
I
--
R
Q
L
------------------
N
-
P
------------
V
W
-
L
R
-
S
-
K
I
G
T
V
S
Q
E
P
I
L
F
S
-
C
-
S
I
A
E
N
I
-
A
Y
G
---------
A
D
D
P
S
S
-
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
FPQ
G
F
N
T
V
V
G
E
-
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
--
M
-
D
--
G
--
R
--
T
V
L
V
I
A
H
H
L
S
-
T
I
K
N
A
N
M
V
A
V
L
D
Q
-
G
K
I
T
E
Y
G
K
H
E
E
-------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
59.44
31%
-84
- C1 -
3TIF
6
Y796_METJA
B:
[21-226]
-----------------------------------------
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
----
D
K
P
T
E
G
E
V
Y
--
I
---
D
N
I
K
T
N
D
-----
L
D
D
------------------
D
-
E
------------
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-
L
L
T
A
L
E
N
V
E
L
P
L
---------
I
F
K
Y
R
G
-
A
M
S
G
E
E
R
---
R
K
R
A
L
E
C
L
K
M
A
---
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
-
M
Q
L
L
K
K
L
NE
E
-
D
--
G
--
K
--
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
E
R
E
------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
59.18
31%
-84
- C1 -
1L2T
4
Y796_METJA
A:
[21-226]
-----------------------------------------
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
----
D
K
P
T
E
G
E
V
Y
--
I
---
D
N
I
K
T
N
D
-----
L
D
D
------------------
D
-
E
------------
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-
L
L
T
A
L
E
N
V
E
L
P
L
---------
I
F
K
Y
R
G
-
A
M
S
G
E
E
R
---
R
K
R
A
L
E
C
L
K
M
A
---
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
-
M
Q
L
L
K
K
L
N
E
E
-
D
--
G
--
K
--
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
E
R
E
------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
57.49
31%
-83
- C1 -
3TIF
7
Y796_METJA
A:
[21-226]
-----------------------------------------
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
----
D
K
P
T
E
G
E
V
Y
--
I
---
D
N
I
K
T
N
D
-----
L
D
D
------------------
D
-
E
------------
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-
L
L
T
A
L
E
N
V
E
L
P
L
---------
I
F
K
Y
R
G
-
A
M
S
G
E
E
R
---
R
K
R
A
L
E
C
L
K
M
A
---
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
-
M
Q
L
L
K
K
L
N
E
E
-
D
--
G
--
K
--
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
E
R
E
------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
49.38
31%
-94
- C1 -
4S0F
2
?
A:
[502-712]
-------------------------------------
K
P
-
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
--
M
----
N
------
F
Y
--
S
PE
K
G
D
I
L
I
N
G
H
S
I
--
K
N
I
------------------
S
-
L
------------
E
L
-
I
R
-
K
-
K
I
A
F
V
S
Q
D
V
F
I
F
S
-
G
-
T
V
K
E
N
L
-
C
L
G
NENVD
M
D
E
I
I
K
A
A
K
M
-
A
N
A
H
D
F
--
I
E
K
L
P
L
K
----
Y
D
---
T
F
---
L
N
E
-
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
-
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
-
K
D
A
I
Y
G
L
--
E
-
D
--
D
--
V
--
T
V
I
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
-
G
E
I
V
E
S
G
S
H
T
E
L
I
A
----------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
48.01
31%
-93
- C1 -
4S0F
2
?
B:
[502-712]
-------------------------------------
K
P
-
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
--
M
----
N
------
F
Y
--
S
PEK
G
D
I
L
I
N
G
H
S
I
--
K
N
I
------------------
S
-
L
------------
E
L
-
I
R
-
K
-
K
I
A
F
V
S
Q
D
V
F
I
F
S
-
G
-
T
V
K
E
N
L
-
C
L
G
NENVDMDEI
I
K
A
A
K
M
-
A
N
A
H
D
F
--
I
E
K
L
P
L
K
----
Y
D
---
T
F
---
L
N
E
-
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
-
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
-
K
D
A
I
Y
G
L
--
E
-
D
--
D
--
V
--
T
V
I
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
-
G
E
I
V
E
S
G
S
H
T
E
L
I
A
----------------------------------------------------------------------------------------------------------------------------------