@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2394: (2016-05-10 )
MSVWLRAGALVAAVMLSLSGCGGFHAGAPSTAGPCEIVPNGTPAPKTPPATVPSSRNLATNPEIATGYRRDMTVVRTAHYAAATANPLATQVACRVLRDGGTAADAVVAAQAVLGLVEPQSSGIGGGGYLVYFDARTGSVQAYDGREVAPAAATENYLRWVSDVDRSAPRPNARASGRSIGVPGILRMLEMVHNEHGRTPWRDLFGPAVTLADGGFDISARMGAAISDAAPQLRDDPEARKYFLNPDGSPKPAGTRLTNPAYSKTLSAIASAGANAFYSGDIAHDIVAAASDTSNGRTPGLLTIEDLAGYLAKRRQPLCTTYRGREICGMPSSGGVAVAATLGILEHFPMSDYAPSKVDLNGGRPTVMGVHLIAEAERLAYADRDQYIADVDFVRLPGGSLTTLVDPGYLAARAALISPQHSMGSARPGDFGAPTAVAPPVPEHGTSHLSVVDSYGNAATLTTTVESSFGSYHLVDGFILNNQLSDFSAEPHATDGSPVANRVEPGKRPRSSMAPTLVFDHSSAGRGALYAVLGSPGGSMIIQFVVKTLVAMLDWGLNPQQAVSLVDFGAANSPHTNLGGENPEINTSDDGDHDPLVQGLRALGHRVNLAEQSSGLSAITRSEAGWAGGADPRREGAVMGDDA
Atome Classification :
(55 SA)
.........10........20........30........40........50........60........70...-.....80........90........100.......110.......120.......130.......140.......150.......160.......170.......-.---180.......190.......200.......210.......220.......230....------....240.......250.......260.......270.......280--.........290.......300.......310.-......320......-.330...--......340.......350-........360.......370.......380.......390.......400.......410.......420...-----.-.--..430---.-....-.-...440....----...450.......460.......470..--.--.--..--.480.......490.--.---...--..--------500.......510.......520.......530.......540.......550.......560.......570.......580-.......-------.590.......600....-----...---610-....---....----620-.-.-.--....630....-...640.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSV
W
L
R
A
G
A
L
V
A
A
V
M
L
S
LSGCGGFHAGAPSTAGP
C
E
IVPNGTPAPKTPPATVPSSRNLATNPEIATGYRR
D
M
T
V
-
V
R
TAHYAAATAN
P
L
A
T
Q
V
A
C
R
V
L
RDGG
T
A
A
D
A
V
V
A
A
Q
A
V
L
G
LVEPQSSGIGGG
G
Y
L
V
Y
F
DARTG
S
V
Q
AYDGREVAP
A
A
A
T
E
N
Y
L
R
W
V
S
D
V
DRSAPR-PNARASGR-S---I
G
V
P
G
I
L
R
M
L
E
M
V
H
NEHGR
T
P
W
R
D
LFGP
A
V
T
LADG
G
F
D
I
S
A
RMGAAISDAA-PQLRD------
D
P
E
A
R
K
Y
F
LNPDGSPKPAGTRLTN
P
A
Y
S
K
T
L
S
A
I
A
S
AGANAFYSG----
D
I
A
H
D
I
V
AAASDTSNGRTP
G
L
L
T
I
E
D
L
A
G
Y
L
A
K-RRQPLCTTYRGREIC-GM--PSS--GG
V
A
V
A
A
T
L
G
I
L
E
HFPMS--DYAPS
K
V
DLNGGR
P
T
V
M
G
V
H
L
I
A
E
A
E
R
L
AYADRD
Q
Y
I
ADV
D
F
V
RLPGG
S
L
T
T
L
VDP
G
Y
L
A
A
R
A
A
LISPQHSMGS-----A-R--PGD-----F-GAPT-A-VAPPVPEHGT----S
H
L
S
V
VDSYGN
A
A
T
L
T
T
T
VESSFG
S
Y
H
L
--
V
--
D
--
G
F
--
I
LNNQLSDFSAEPHA--T---DGS--PV--------ANRVEPGKRPRSSMA
P
T
L
V
F
DHSSAGR
G
A
L
Y
A
V
LGSP
G
G
S
M
I
I
Q
F
V
V
K
T
L
V
A
M
L
DWGL
N
P
Q
Q
A
V
S
L
V
DFGAANSPHTNLGGE--NPEINTS-------DDGD
H
D
P
L
V
Q
G
L
R
A
LGHR-----VN
L
---
A
-
E
-QSSG---
L
S
A
I
----TRS-E-A-G--WAGGADPRREG-AVMGDDA
51
HHSearch
96.81
34%
-67
* C4 *
4Y23
1
?
A:
[36-579]
------------------------------------------------------------------------
K
V
-
A
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
R
A
P
E
G
A
K
P
D
M
F
--
L
D
E
D
G
K
V
I
P
F
-
S
E
R
S
R
H
G
N
-
A
---
V
G
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
-
D
K
L
S
K
-------
T
A
A
K
D
I
F
L
-
P
D
G
E
P
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
L
I
R
K
E
G
S
K
A
F
Y
D
G
----
E
I
G
R
A
I
A
D
V
V
Q
D
-----
F
G
G
S
M
T
P
D
D
L
S
R
Y
E
V
T
-
T
D
K
P
I
W
G
E
Y
H
G
Y
D
I
A
-
S
M
P
P
P
S
S
--
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
L
S
--
Q
Y
D
---------
P
K
S
F
E
K
Y
H
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
A
Y
A
G
D
P
E
F
V
D
V
P
---
L
R
G
L
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
S
M
N
R
D
VKEGD
P
W
K
--
Y
E
E
-----
G
E
P
N
Y
E
I
V
P
Q
P
E
D
K
T
I
G
E
A
----
T
H
F
T
V
T
D
Q
W
G
N
V
V
S
Y
T
T
T
I
E
Q
L
F
G
T
G
I
L
--
V
PG
Y
--
G
L
--
F
L
N
N
E
L
T
D
F
D
A
I
P
G
-------------
G
--------
A
N
E
V
Q
P
N
K
R
P
L
S
S
M
T
P
T
I
V
F
K
-----
D
E
K
P
V
L
T
V
G
S
P
G
G
T
T
I
I
A
S
V
F
Q
T
I
L
N
Y
F
E
Y
G
M
S
L
Q
D
A
I
E
E
P
R
I
Y
------
T
N
S
L
T
S
Y
-
R
Y
E
S
------------
G
M
P
E
D
V
R
R
K
L
N
D
F
G
H
K
-----
F
G
S
N
--
P
-
V
-
D
I
G
N
---
V
Q
S
I
----
F
I
D
R
E
-
N
K
T
--
F
M
G
V
A
D
S
S
R
N
G
-
T
A
V
G
V
N
-
1
PsiBlast_PDB
93.37
32%
-59
- C4 -
4Y23
1
?
A:
[45-577]
----------------------------------------------------------------------------------
V
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
R
A
P
E
G
A
K
P
D
--
M
F
L
D
E
D
G
K
V
I
P
F
-
S
E
R
S
R
H
G
N
-
A
---
V
G
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
-
D
K
L
S
-------
K
T
A
A
K
D
I
F
L
-
P
D
G
E
P
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
L
I
R
K
E
G
S
K
A
F
Y
D
G
----
E
I
G
R
A
I
A
D
V
V
Q
D
F
G
G
S
M
T
P
-----
D
D
L
S
R
Y
E
V
T
-
T
D
K
P
I
W
G
E
Y
H
G
Y
D
I
A
-
S
M
P
P
P
S
S
--
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
L
S
--
Q
Y
D
P
K
S
F
E
---------
K
Y
H
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
A
Y
A
G
D
P
E
F
V
D
V
P
---
L
R
G
L
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
S
M
N
R
D
-----
V
-
K
--
E
G
D
PWKYE
E
-
G
E
P
N
-
Y
-
E
I
V
P
Q
P
E
D
K
T
I
G
E
A
T
H
F
T
V
T
D
Q
W
G
N
V
V
S
Y
T
T
T
I
E
Q
L
F
G
T
G
I
L
--
V
--
P
--
G
Y
G
L
F
L
N
N
E
L
T
D
F
D
A
I
P
G
G
---------------------
A
N
E
V
Q
P
N
K
R
P
L
S
S
M
T
P
T
I
V
F
K
D
E
K
P
-----
V
L
T
V
G
S
P
G
G
T
T
I
I
A
S
V
F
Q
T
I
L
N
Y
F
E
Y
G
M
S
L
Q
D
A
I
-----------------
E
--
E
P
R
I
Y
T
N
SLT
S
Y
R
Y
E
S
G
M
P
E
D
V
R
R
K
L
N
D
F
G
H
K
F
G
S
N
P
V
D
I
---
G
-
N
-
V
Q
S
I
---
F
--
I
----
D
R
E
-
N
-
K
-
T
--
F
M
G
V
A
D
S
S
R
N
G
-
T
A
V
G
---
53
HHSearch
86.78
25%
-68
- C4 -
2NLZ
-
?
A:
[15-539]
----------------------------------------------------------------------
R
R
N
V
-
V
Y
A
K
N
G
M
V
A
T
S
Q
P
L
A
A
Q
A
G
L
D
I
L
K
A
G
G
N
A
I
D
A
A
I
A
T
A
T
A
L
T
V
L
E
P
T
S
N
G
I
G
S
D
A
F
A
L
V
W
T
K
G
--
K
L
H
G
L
N
G
S
G
R
A
P
M
S
L
T
M
E
A
V
--
K
A
K
G
-
Y
E
Q
---
E
L
P
P
Y
G
V
I
-
P
---
V
T
V
P
G
A
P
G
A
W
A
E
L
A
K
M
Y
G
N
L
P
L
A
A
S
L
A
P
A
I
R
Y
A
E
E
G
Y
P
V
T
P
T
L
A
K
Y
W
K
A
A
Y
-
D
R
V
K
T
EWTDDV
Y
Q
P
W
F
D
T
F
A
-
P
K
G
R
A
P
R
V
G
E
V
W
R
S
Q
G
H
A
D
T
L
R
S
I
A
E
S
N
G
E
S
F
Y
R
G
----
E
L
A
D
Q
I
H
A
F
F
D
K
-----
H
G
G
Y
L
T
K
E
D
L
A
C
Y
R
P
E
-
W
V
E
P
I
S
I
D
Y
R
G
Y
R
V
W
-
E
I
P
P
N
G
Q
--
G
L
V
-
A
L
E
A
L
N
I
V
K
G
F
E
F
Y
--
H
K
-----------
D
T
V
D
T
Y
H
K
Q
I
E
A
M
K
L
A
F
V
D
G
M
K
Y
V
T
E
P
S
D
M
S
V
S
---
V
E
Q
L
L
S
D
E
Y
A
T
E
R
R
K
E
I
G
E
-
Q
A
L
T
-------------------
P
-
E
-------
P
G
T
P
----
T
----
V
Y
L
A
T
A
D
G
D
G
N
M
V
S
F
I
Q
S
N
Y
M
G
F
G
S
G
V
V
--
V
PG
T
--
G
I
--
A
M
Q
N
R
G
H
N
F
S
L
D
P
N
-------------
H
--------
D
N
A
L
K
P
G
K
R
T
Y
H
T
I
I
P
G
F
L
T
K
-----
N
D
Q
P
I
G
P
F
G
V
M
G
G
F
M
Q
P
Q
G
H
M
Q
V
M
M
N
T
I
D
F
G
L
N
P
Q
A
A
L
D
A
P
R
W
Q
------
W
T
N
G
K
Q
V
-
Q
V
E
P
------------
T
F
P
V
D
I
A
Q
A
L
V
R
R
G
H
K
-----
I
Q
V
V
LD
E
-
G
-
A
F
G
R
---
G
Q
I
I
----
W
R
D
-
P
T
T
G
V
--
L
A
G
G
T
E
P
R
T
D
G
-
Q
V
A
A
W
--
73
Fugue
75.02
25%
-39
- C4 -
2I3O
-
?
D:
[2-516]
--------------------------------------
F
R
S
R
P
N
A
L
S
Q
R
S
V
I
A
S
S
-------------------------------
S
E
L
A
S
L
A
G
R
D
I
L
K
R
G
G
N
I
F
D
A
A
L
A
V
S
A
-
L
C
V
T
Q
N
N
L
C
G
L
G
G
D
L
F
A
L
I
R
D
-
E
N
G
Q
I
D
L
N
G
S
G
Q
A
S
R
A
V
S
I
D
Y
Y
E
S
G
L
T
K
I
P
E
R
G
P
Y
-
A
--------
A
---
I
T
V
P
G
I
A
G
S
W
D
E
I
F
R
K
F
A
-
T
D
I
A
D
I
L
E
P
A
I
R
T
A
S
A
G
F
P
I
T
Q
N
Y
S
D
S
I
A
R
S
A
-
P
V
I
G
Q
------
Y
R
G
W
S
S
I
F
--
P
N
G
S
V
P
V
A
G
E
I
L
K
Q
P
D
L
A
E
S
F
R
-
L
S
E
E
G
F
R
S
F
Y
D
G
----
S
L
A
D
I
I
I
A
G
L
E
G
T
G
S
P
-----
L
S
D
R
D
L
R
V
Y
R
P
L
-
I
G
K
P
V
F
T
D
L
D
E
F
R
I
Y
E
T
S
--
P
N
S
--
Q
G
I
T
V
I
E
W
I
R
G
E
S
H
G
Y
D
S
--
R
T
W
E
A
K
------------
I
E
D
I
F
E
T
E
-
E
A
Y
D
K
R
R
K
-----------------
I
T
D
P
S
Y
N
I
A
Q
H
---
D
S
A
N
G
K
G
L
-----
P
-
K
RD
H
N
D
-----
I
-
G
--------------
D
T
----
T
Y
F
S
I
S
D
S
E
G
R
S
V
S
I
I
Q
S
N
Y
G
-
F
G
S
G
I
V
--
P
--
K
GT
G
F
--
V
L
Q
N
R
G
S
Y
F
T
L
Q
R
D
H
--
P
---
N
A
L
--
P
---------------
G
K
R
T
F
H
T
L
A
A
C
V
E
K
E
H
------
D
L
Y
A
S
L
G
S
G
G
D
---
I
Q
P
Q
V
Q
Q
I
L
E
I
L
K
D
N
T
D
P
Q
A
I
L
D
K
P
R
W
T
E
P
Y
T
I
Y
E
A
P
G
------
A
V
Y
V
E
-------
S
E
E
L
Y
R
N
V
S
K
Q
I
S
G
R
K
V
V
-----
L
R
D
---
V
-
S
-
Q
E
F
G
---
T
A
Q
I
----
T
T
L
-
I
-
R
-
G
DV
V
V
G
A
A
D
P
R
G
D
G
-
I
A
I
P
Y
S
-
55
HHSearch
74.61
36%
-83
- C4 -
3WHR
-
?
A:
[39-380]
-----------------------------------------------------------------------
K
Q
V
-
D
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
F
--
L
D
E
N
G
K
A
I
P
F
-
S
E
R
V
T
K
G
T
-
A
---
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
L
S
R
------
T
-
A
A
K
D
V
F
L
-
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
----
K
F
A
K
T
L
S
D
T
V
Q
D
-----
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
-
T
T
P
P
P
S
S
--
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
--
Q
Y
D
---------
V
R
S
W
E
K
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
---
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
-----
P
-
K
--
A
G
D
-----
P
-
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.84
34%
-78
- C4 -
2V36
-
GGT_BACSU
A:
[50-378]
-----------------------------------------------------------------------------------
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
--
M
F
L
D
E
N
G
K
A
I
P
F
-
S
E
R
V
T
K
G
T
-
A
---
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
L
S
-------
R
T
A
A
K
D
V
F
L
-
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
----
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
-----
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
-
T
T
P
P
P
S
S
--
G
G
I
F
L
L
Q
M
P
K
I
L
D
H
F
N
L
S
---------
D
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
---
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
-----
P
-
K
--
A
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.80
34%
-82
- C4 -
3A75
1
?
A:
[31-360]
----------------------------------------------------------------------------------
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
--
F
L
D
E
N
G
K
A
I
P
F
-
S
E
R
V
T
K
G
T
-
A
---
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
L
S
-------
R
T
A
A
K
D
V
F
L
-
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
----
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
-----
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
-
T
T
P
P
P
S
S
--
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
--
Q
Y
-----
D
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
---
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
-----
P
-
K
--
A
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
73.79
34%
-80
- C4 -
3A75
1
?
C:
[31-360]
----------------------------------------------------------------------------------
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
--
F
L
D
E
N
G
K
A
I
P
F
-
S
E
R
V
T
K
G
T
-
A
---
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
L
S
-------
R
T
A
A
K
D
V
F
L
-
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
----
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
-----
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
-
T
T
P
P
P
S
S
--
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
--
Q
Y
-----
D
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
---
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
-----
P
-
K
--
A
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.55
34%
-79
- C4 -
3WHR
-
?
A:
[49-378]
----------------------------------------------------------------------------------
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
--
F
L
D
E
N
G
K
A
I
P
F
-
S
E
R
V
T
K
G
T
-
A
---
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
L
S
R
------
T
A
-
A
K
D
V
F
L
-
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
----
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
-----
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
-
T
T
P
P
P
S
S
--
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
--
Q
Y
-----
D
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
---
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
-----
P
-
K
--
A
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.46
34%
-81
- C4 -
3WHQ
-
GGT_BACSU
A:
[49-378]
----------------------------------------------------------------------------------
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
--
F
L
D
E
N
G
K
A
I
P
F
-
S
E
R
V
T
K
G
T
-
A
---
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
L
S
R
------
T
A
-
A
K
D
V
F
L
-
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
----
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
-----
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
-
T
T
P
P
P
S
S
--
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
--
Q
Y
-----
D
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
---
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
-----
P
-
K
--
A
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.01
33%
-71
- C4 -
4OTU
1
?
A:
[46-395]
-----------------------------------------------------------------------------------
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
R
A
P
E
G
A
K
P
D
M
--
F
L
D
E
D
G
K
V
I
P
F
-
S
E
R
S
R
H
G
N
-
A
---
V
G
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
-
D
K
L
S
-------
K
T
A
A
K
D
I
F
L
-
P
D
G
E
P
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
L
I
R
K
E
G
S
K
A
F
Y
D
G
----
E
I
G
R
A
I
A
D
V
V
Q
D
F
G
G
S
M
T
P
-----
D
D
L
S
R
Y
E
V
T
-
T
D
K
P
I
W
G
E
Y
H
G
Y
D
I
A
-
S
M
P
P
P
S
S
--
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
L
S
--
Q
Y
D
P
K
S
F
E
---------
K
Y
H
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
A
Y
A
G
D
P
E
F
V
D
V
P
---
L
R
G
L
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
S
M
N
R
D
-----
V
-
K
--
E
G
D
PWKYE
E
-
G
E
P
N
-
Y
-
E
I
V
P
Q
P
E
D
K
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.72
33%
-73
- C4 -
4OTT
1
?
A:
[46-391]
-----------------------------------------------------------------------------------
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
R
A
P
E
G
A
K
P
D
M
--
F
L
D
E
D
G
K
V
I
P
F
-
S
E
R
S
R
H
G
N
-
A
---
V
G
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
-
D
K
L
S
-------
K
T
A
A
K
D
I
F
L
-
P
D
G
E
P
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
L
I
R
K
E
G
S
K
A
F
Y
D
G
----
E
I
G
R
A
I
A
D
V
V
Q
D
F
G
G
S
M
T
P
-----
D
D
L
S
R
Y
E
V
T
-
T
D
K
P
I
W
G
E
Y
H
G
Y
D
I
A
-
S
M
P
P
P
S
S
--
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
L
S
--
Q
Y
D
P
K
S
F
E
---------
K
Y
H
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
A
Y
A
G
D
P
E
F
V
D
V
P
---
L
R
G
L
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
S
M
N
R
D
-----
V
-
K
--
E
G
D
PWKYE
E
-
G
E
P
N
-
Y
-
E
I
V
P
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.61
34%
-79
- C4 -
3WHS
1
GGT_BACSU
A:
[65-394]
----------------------------------------------------------------------------------
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
--
F
L
D
E
N
G
K
A
I
P
F
-
S
E
R
V
T
K
G
T
-
A
---
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
L
S
R
------
T
A
-
A
K
D
V
F
L
-
P
N
G
E
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
----
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
-----
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
-
T
T
P
P
P
S
S
--
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
--
Q
Y
-----
D
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
---
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
-----
P
-
K
--
A
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
72.54
34%
-88
- C4 -
2QMC
1
?
A:
[31-357]
---------------------------------------------------------------------------
K
N
T
K
V
G
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
-
G
E
N
V
A
L
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
--
L
D
K
Q
G
N
V
V
P
--
K
L
S
E
D
G
Y
L
-
A
---
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
K
------
Y
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
----
Q
V
A
E
L
I
E
K
D
M
K
K
-----
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
-
S
M
S
P
P
S
S
--
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
--
A
L
G
---------
Y
G
A
S
K
N
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
---
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.64
32%
-81
- C4 -
2NQO
-
?
A:
[40-358]
----------------------------------------------------------------------------------
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
-
A
L
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
-----
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
G
Y
L
A
---
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
K
------
Y
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
----
Q
V
A
E
L
I
-----
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
-
S
M
S
P
P
S
S
--
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
AL
G
Y
G
A
S
K
-----------
N
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
---
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.53
32%
-84
- C4 -
2QMC
1
?
A:
[38-356]
----------------------------------------------------------------------------------
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
-
A
L
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
-----
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
G
Y
L
A
---
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
K
------
Y
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
----
Q
V
A
E
L
I
-----
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
-
S
M
S
P
P
S
S
--
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
AL
G
Y
G
A
S
K
-----------
N
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
---
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.42
31%
-74
- C4 -
2E0X
-
?
A:
[6-361]
-------------------------------------------------------------
P
P
V
S
Y
G
V
E
E
D
V
F
H
P
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
-
F
M
L
I
R
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
-----
L
D
D
Q
G
-
N
-
P
D
S
K
K
S
L
T
-
S
HLA
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
-
S
E
V
L
P
------
N
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
----
T
I
A
E
Q
I
--
A
Q
E
M
Q
K
N
G
---
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
-
S
M
P
P
P
S
S
--
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
--
K
Y
G
F
G
S
A
D
---------
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
-------
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
-----
A
-
K
--
P
S
S
-----
E
-
I
R
P
G
-
K
-
L
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
70.27
33%
-93
- C4 -
2DG5
2
?
A:
[17-345]
-----------------------------------------------------------------------
F
H
P
-
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
S
K
N
-
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
--
L
D
D
Q
G
N
P
D
S
--
K
K
S
L
T
S
H
L
-
A
---
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
------
H
E
N
S
K
A
I
F
W
-
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
----
T
I
A
E
Q
I
A
Q
E
M
Q
K
-----
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
-
S
M
P
P
P
S
S
--
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
--
K
Y
G
---------
F
G
S
A
D
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
---
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.27
32%
-83
- C4 -
3FNM
1
?
A:
[38-356]
----------------------------------------------------------------------------------
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
-
A
L
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
-----
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
G
Y
L
A
---
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
K
------
Y
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
----
Q
V
A
E
L
I
-----
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
-
S
M
S
P
P
S
S
--
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
AL
G
Y
G
A
S
K
-----------
N
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
---
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.26
32%
-83
- C4 -
2QM6
1
?
A:
[38-356]
----------------------------------------------------------------------------------
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
-
A
L
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
-----
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
G
Y
L
A
---
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
K
------
Y
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
----
Q
V
A
E
L
I
-----
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
-
S
M
S
P
P
S
S
--
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
AL
G
Y
G
A
S
K
-----------
N
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
---
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
70.16
32%
-83
- C4 -
2QM6
1
?
C:
[38-356]
----------------------------------------------------------------------------------
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
-
A
L
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
-----
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
G
Y
L
A
---
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
K
------
Y
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
----
Q
V
A
E
L
I
-----
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
-
S
M
SP
P
S
S
--
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
AL
G
Y
G
A
S
K
-----------
N
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
---
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
69.71
32%
-82
- C4 -
3FNM
1
?
C:
[38-356]
----------------------------------------------------------------------------------
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
-
A
L
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
-----
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
G
Y
L
A
---
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
K
------
Y
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
----
Q
V
A
E
L
I
-----
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
-
S
M
S
P
P
S
S
--
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
AL
G
Y
G
A
S
K
-----------
N
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
---
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
69.59
31%
-76
- C4 -
2DG5
2
?
A:
[13-361]
--------------------------------------------------------------------
E
E
D
V
F
H
P
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
-
F
M
L
I
R
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
-----
L
D
D
Q
G
-
N
-
P
D
S
K
K
S
L
T
-
S
HLA
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
-
S
E
V
L
P
------
N
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
----
T
I
A
E
Q
I
--
A
Q
E
M
Q
K
N
G
---
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
-
S
M
P
P
P
S
S
--
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
--
K
Y
G
F
G
S
A
D
---------
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
-------
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
-----
A
-
K
--
P
S
S
-----
E
-
I
R
P
G
-
K
-
L
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
69.57
32%
-84
- C4 -
2QMC
1
?
C:
[38-356]
----------------------------------------------------------------------------------
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
-
A
L
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
-----
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
G
Y
L
A
---
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
K
------
Y
S
S
S
K
K
Y
F
F
K
K
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
----
Q
V
A
E
L
I
-----
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
-
S
M
SP
P
S
S
--
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
AL
G
Y
G
A
S
K
-----------
N
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
---
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.53
31%
-74
- C4 -
2DBW
2
?
A:
[6-361]
-------------------------------------------------------------
P
P
V
S
Y
G
V
E
E
D
V
F
H
P
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
-
F
M
L
I
R
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
-----
L
D
D
Q
G
-
N
-
P
D
S
K
K
S
L
T
-
S
HLA
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
-
S
E
V
L
P
------
N
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
----
T
I
A
E
Q
I
--
A
Q
E
M
Q
K
N
G
---
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
-
S
M
P
P
P
S
S
--
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
--
K
Y
G
F
G
S
A
D
---------
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
-------
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
-----
A
-
K
--
P
S
S
-----
E
-
I
R
P
G
-
K
-
L
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
69.24
32%
-70
- C4 -
2Z8K
1
GGT_ECOLI
C:
[14-361]
---------------------------------------------------------------------
E
D
V
F
H
P
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
-
I
R
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
L
---
D
D
Q
G
N
P
D
S
-
K
K
S
L
T
S
H
L
-
A
---
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
-
S
E
V
L
P
------
N
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
----
T
I
A
E
Q
I
--
A
Q
E
M
Q
K
N
G
---
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
-
S
M
PP
P
S
S
--
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
--
K
Y
G
F
G
S
A
D
---------
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
-------
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
-----
A
-
K
--
P
S
S
-----
E
-
I
R
P
G
-
K
-
L
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
69.19
31%
-76
- C4 -
2DBX
2
GGT_ECOLI
A:
[13-361]
--------------------------------------------------------------------
E
E
D
V
F
H
P
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
-
F
M
L
I
R
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
-----
L
D
D
Q
G
-
N
-
P
D
S
K
K
S
L
T
-
S
HLA
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
-
S
E
V
L
P
------
N
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
----
T
I
A
E
Q
I
--
A
Q
E
M
Q
K
N
G
---
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
-
S
M
P
P
P
S
S
--
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
--
K
Y
G
F
G
S
A
D
---------
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
-------
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
-----
A
-
K
--
P
S
S
-----
E
-
I
R
P
G
-
K
-
L
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.02
32%
-73
- C4 -
2Z8K
1
GGT_ECOLI
A:
[14-361]
---------------------------------------------------------------------
E
D
V
F
H
P
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
-
I
R
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
L
---
D
D
Q
G
N
P
D
S
-
K
K
S
L
T
S
H
L
-
A
---
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
-
S
E
V
L
P
------
N
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
----
T
I
A
E
Q
I
--
A
Q
E
M
Q
K
N
G
---
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
-
S
M
P
P
P
S
S
--
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
--
K
Y
G
F
G
S
A
D
---------
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
-------
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
-----
A
-
K
--
P
S
S
-----
E
-
I
R
P
G
-
K
-
L
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
68.96
32%
-71
- C4 -
2Z8I
1
?
C:
[15-361]
----------------------------------------------------------------------
D
V
F
H
P
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
-
I
R
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
L
---
D
D
Q
G
N
P
D
S
-
K
K
S
L
T
S
H
L
-
A
---
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
-
S
E
V
L
P
------
N
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
----
T
I
A
E
Q
I
--
A
Q
E
M
Q
K
N
G
---
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
-
S
M
P
P
P
S
S
--
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
--
K
Y
G
F
G
S
A
D
---------
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
-------
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
-----
A
-
K
--
P
S
S
-----
E
-
I
R
P
G
-
K
-
L
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.86
32%
-72
- C4 -
2Z8I
1
?
A:
[14-361]
---------------------------------------------------------------------
E
D
V
F
H
P
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
-
I
R
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
L
---
D
D
Q
G
N
P
D
S
-
K
K
S
L
T
S
H
L
-
A
---
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
-
S
E
V
L
P
------
N
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
----
T
I
A
E
Q
I
--
A
Q
E
M
Q
K
N
G
---
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
-
S
M
P
P
P
S
S
--
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
--
K
Y
G
F
G
S
A
D
---------
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
-------
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
-----
A
-
K
--
P
S
S
-----
E
-
I
R
P
G
-
K
-
L
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.64
32%
-72
- C4 -
2Z8J
1
GGT_ECOLI
A:
[14-361]
---------------------------------------------------------------------
E
D
V
F
H
P
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
-
I
R
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
L
---
D
D
Q
G
N
P
D
S
-
K
K
S
L
T
S
H
L
-
A
---
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
-
S
E
V
L
P
------
N
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
----
T
I
A
E
Q
I
--
A
Q
E
M
Q
K
N
G
---
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
-
S
M
P
P
P
S
S
--
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
--
K
Y
G
F
G
S
A
D
---------
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
-------
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
-----
A
-
K
--
P
S
S
-----
E
-
I
R
P
G
-
K
-
L
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
68.35
32%
-88
- C4 -
4GDX
9
GGT1_HUMAN
A:
[36-359]
---------------------------------------------------------------------------
H
V
Y
T
R
A
A
V
A
A
D
A
K
Q
C
S
K
I
G
R
D
A
L
R
D
G
G
S
A
V
D
A
A
I
A
A
L
L
C
V
G
L
M
N
A
H
S
M
G
I
G
G
G
L
F
L
T
I
Y
N
S
T
T
R
K
A
E
V
I
N
A
R
E
V
A
P
R
L
A
F
A
T
M
F
--
N
S
S
--------
E
Q
S
Q
K
G
G
L
-
S
---
V
A
V
P
G
E
I
R
G
Y
E
L
A
H
Q
R
H
G
R
L
P
W
A
R
L
F
Q
P
S
I
Q
L
A
R
Q
G
F
P
V
G
K
G
L
A
A
A
L
E
N
K
R
-
T
V
I
E
Q
------
Q
P
V
L
C
E
V
F
C
-
R
D
R
K
V
L
R
E
G
E
R
L
T
L
P
Q
L
A
D
T
Y
E
T
L
A
I
E
G
A
Q
A
F
Y
N
G
----
S
L
T
A
Q
I
V
K
D
I
Q
A
-----
A
G
G
I
V
T
A
E
D
L
N
N
Y
R
A
E
L
I
E
H
P
L
N
I
S
L
G
D
A
V
L
Y
-
M
P
S
A
P
L
S
--
G
P
V
-
L
A
L
I
L
N
I
L
K
G
Y
N
F
S
--
R
E
S
V
-----
E
S
P
E
Q
K
G
L
T
Y
H
R
I
V
E
A
F
R
F
A
Y
A
K
R
T
-
L
L
G
D
P
K
F
V
D
V
T
-
E
V
V
R
N
M
T
S
E
F
F
A
A
Q
L
R
A
Q
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
67.90
32%
-69
- C4 -
2Z8J
1
?
C:
[14-361]
---------------------------------------------------------------------
E
D
V
F
H
P
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
-
I
R
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
L
---
D
D
Q
G
N
P
D
S
-
K
K
S
L
T
S
H
L
-
A
---
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
-
S
E
V
L
P
------
N
H
E
N
S
K
A
I
F
W
K
E
G
E
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
----
T
I
A
E
Q
I
--
A
Q
E
M
Q
K
N
G
---
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
-
S
M
PP
P
S
S
--
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
--
K
Y
G
F
G
S
A
D
---------
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
-------
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
-----
A
-
K
--
P
S
S
-----
E
-
I
R
P
G
-
K
-
L
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
65.78
32%
-83
- C4 -
4ZC6
6
GGT1_HUMAN
A:
[31-309]
-------------------------------------------------------------------------------------------------
L
R
D
G
G
S
A
V
D
A
A
I
A
A
L
L
C
V
G
L
M
N
A
H
S
M
G
I
G
G
G
L
F
L
T
I
Y
N
S
T
T
R
K
A
E
V
I
N
A
R
E
V
A
P
R
L
A
------
F
A
T
M
F
N
S
S
----
E
Q
S
Q
K
G
G
L
-
S
---
V
A
V
P
G
E
I
R
G
Y
E
L
A
H
Q
R
H
G
R
L
P
W
A
R
L
F
Q
P
S
I
Q
L
A
R
Q
G
F
P
V
G
K
G
L
A
A
A
L
E
N
K
R
-
T
V
I
E
Q
------
Q
P
V
L
C
E
V
F
C
R
-
D
R
K
V
L
R
E
G
E
R
L
T
L
P
Q
L
A
D
T
Y
E
T
L
A
I
E
G
A
Q
A
F
Y
N
G
SL
T
A
Q
I
V
K
D
I
Q
A
A
G
---------
G
I
V
T
A
E
D
L
N
N
Y
R
A
E
-
L
I
E
H
P
L
N
I
S
L
G
D
A
V
L
-
Y
M
--
P
S
A
PL
S
G
P
V
L
A
L
I
L
N
I
L
K
G
Y
N
F
S
--
R
E
S
V
E
S
P
E
Q
K
G
-----
L
T
Y
H
R
I
V
E
A
F
R
F
A
Y
A
K
R
T
-
L
L
G
D
P
K
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
65.56
32%
-85
- C4 -
4ZCG
6
?
A:
[31-309]
-------------------------------------------------------------------------------------------------
L
R
D
G
G
S
A
V
D
A
A
I
A
A
L
L
C
V
G
L
M
N
A
H
S
M
G
I
G
G
G
L
F
L
T
I
Y
N
S
T
T
R
K
A
E
V
I
N
A
R
E
V
A
P
R
L
A
------
F
A
T
M
F
N
S
S
----
E
Q
S
Q
K
G
G
L
-
S
---
V
A
V
P
G
E
I
R
G
Y
E
L
A
H
Q
R
H
G
R
L
P
W
A
R
L
F
Q
P
S
I
Q
L
A
R
Q
G
F
P
V
G
K
G
L
A
A
A
L
E
N
K
R
-
T
V
I
E
Q
------
Q
P
V
L
C
E
V
F
C
R
-
D
R
K
V
L
R
E
G
E
R
L
T
L
P
Q
L
A
D
T
Y
E
T
L
A
I
E
G
A
Q
A
F
Y
N
G
SL
T
A
Q
I
V
K
D
I
Q
A
A
G
---------
G
I
V
T
A
E
D
L
N
N
Y
R
A
E
-
L
I
E
H
P
L
N
I
S
L
G
D
A
V
L
-
Y
M
--
P
S
A
PL
S
G
P
V
L
A
L
I
L
N
I
L
K
G
Y
N
F
S
--
R
E
S
V
E
S
P
E
Q
K
G
-----
L
T
Y
H
R
I
V
E
A
F
R
F
A
Y
A
K
R
T
-
L
L
G
D
P
K
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
64.95
32%
-84
- C4 -
4GDX
6
GGT1_HUMAN
A:
[58-336]
-------------------------------------------------------------------------------------------------
L
R
D
G
G
S
A
V
D
A
A
I
A
A
L
L
C
V
G
L
M
N
A
H
S
M
G
I
G
G
G
L
F
L
T
I
Y
N
S
T
T
R
K
A
E
V
I
N
A
R
E
V
A
P
R
L
A
F
A
T
M
F
N
---------
S
S
-
E
Q
S
Q
K
G
G
L
-
S
---
V
A
V
P
G
E
I
R
G
Y
E
L
A
H
Q
R
H
G
R
L
P
W
A
R
L
F
Q
P
S
I
Q
L
A
R
Q
G
F
P
V
G
K
G
L
A
A
A
L
E
N
K
R
-
T
V
I
E
Q
------
Q
P
V
L
C
E
V
F
C
R
-
D
R
K
V
L
R
E
G
E
R
L
T
L
P
Q
L
A
D
T
Y
E
T
L
A
I
E
G
A
Q
A
F
Y
N
G
SL
T
A
Q
I
V
K
D
I
Q
A
A
G
---------
G
I
V
T
A
E
D
L
N
N
Y
R
A
E
-
L
I
E
H
P
L
N
I
S
L
G
D
A
V
L
-
Y
M
--
P
S
A
PL
S
G
P
V
L
A
L
I
L
N
I
L
K
G
Y
N
F
S
--
R
E
S
V
E
S
P
E
Q
K
G
-----
L
T
Y
H
R
I
V
E
A
F
R
F
A
Y
A
K
R
T
-
L
L
G
D
P
K
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
64.84
32%
-85
- C4 -
4ZBK
8
?
A:
[31-309]
-------------------------------------------------------------------------------------------------
L
R
D
G
G
S
A
V
D
A
A
I
A
A
L
L
C
V
G
L
M
N
A
H
S
M
G
I
G
G
G
L
F
L
T
I
Y
N
S
T
T
R
K
A
E
V
I
N
A
R
E
V
A
P
R
L
A
------
F
A
T
M
F
N
S
S
----
E
Q
S
Q
K
G
G
L
-
S
---
V
A
V
P
G
E
I
R
G
Y
E
L
A
H
Q
R
H
G
R
L
P
W
A
R
L
F
Q
P
S
I
Q
L
A
R
Q
G
F
P
V
G
K
G
L
A
A
A
L
E
N
K
R
-
T
V
I
E
Q
------
Q
P
V
L
C
E
V
F
C
R
-
D
R
K
V
L
R
E
G
E
R
L
T
L
P
Q
L
A
D
T
Y
E
T
L
A
I
E
G
A
Q
A
F
Y
N
G
SL
T
A
Q
I
V
K
D
I
Q
A
A
G
---------
G
I
V
T
A
E
D
L
N
N
Y
R
A
E
-
L
I
E
H
P
L
N
I
S
L
G
D
A
V
L
-
Y
M
--
P
S
A
PL
S
G
P
V
L
A
L
I
L
N
I
L
K
G
Y
N
F
S
--
R
E
S
V
E
S
P
E
Q
K
G
-----
L
T
Y
H
R
I
V
E
A
F
R
F
A
Y
A
K
R
T
-
L
L
G
D
P
K
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
48.15
31%
-45
- C4 -
2QM6
1
?
D:
[1-186]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
Y
S
V
A
D
R
W
G
N
A
V
S
V
T
Y
T
I
N
A
S
Y
G
S
A
A
S
--
I
--
D
GA
G
F
--
L
L
N
N
E
M
D
D
F
S
I
K
P
---------
G
N
--
P
N
LYGLVGGD
A
N
A
I
E
A
N
K
R
P
L
S
S
M
S
P
T
I
V
L
K
N
N
K
-----
V
F
L
V
V
G
S
P
G
G
S
R
I
I
T
T
V
L
Q
V
I
S
N
V
I
D
Y
N
M
N
I
S
E
A
V
S
--------
A
P
R
F
H
M
Q
W
L
--
P
D
E
L
R
I
E
-------
K
F
G
M
P
A
D
V
K
D
N
L
T
K
M
G
Y
Q
-----
I
V
T
---
K
-
P
-
V
M
G
D
---
V
N
A
I
QVLP
K
T
K
-
G
-
S
-
V
--
F
Y
G
S
T
D
P
R
K
----------
35
PsiBlast_CBE
47.67
31%
-42
- C4 -
3FNM
1
?
B:
[1-187]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
Y
S
V
A
D
R
W
G
N
A
V
S
V
T
Y
T
I
N
A
S
Y
G
S
A
A
S
--
I
--
D
GA
G
F
--
L
L
N
N
E
M
D
D
F
S
I
K
P
---------
G
N
--
P
N
LYG
L
V
G
G
D
A
N
A
I
E
A
N
K
R
P
L
S
S
M
S
P
T
I
V
L
K
N
N
K
-----
V
F
L
V
V
G
S
P
G
G
S
R
I
I
T
T
V
L
Q
V
I
S
N
V
I
D
Y
N
M
N
I
S
E
A
V
S
--------
A
P
R
F
H
M
Q
W
L
--
P
D
E
L
R
I
E
-------
K
F
G
M
P
A
D
V
K
D
N
L
T
K
M
G
Y
Q
-----
I
V
T
---
K
-
P
-
V
M
G
D
---
V
N
A
I
Q
V
L
P
K
T
K
-
G
-
S
-
V
--
F
Y
G
S
T
D
P
R
K
E
---------
37
PsiBlast_CBE
47.54
31%
-47
- C4 -
2QM6
1
?
B:
[1-186]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
Y
S
V
A
D
R
W
G
N
A
V
S
V
T
Y
T
I
N
A
S
Y
G
S
A
A
S
--
I
--
D
GA
G
F
--
L
L
N
N
E
M
D
D
F
S
I
K
P
---------
G
N
--
P
N
LYG
L
V
G
G
D
A
N
A
I
E
A
N
K
R
P
L
S
S
M
S
P
T
I
V
L
K
N
N
K
-----
V
F
L
V
V
G
S
P
G
G
S
R
I
I
T
T
V
L
Q
V
I
S
N
V
I
D
Y
N
M
N
I
S
E
A
V
S
--------
A
P
R
F
H
M
Q
W
L
--
P
D
E
L
R
I
E
-------
K
F
G
M
P
A
D
V
K
D
N
L
T
K
M
G
Y
Q
-----
I
V
T
---
K
-
P
-
V
M
G
D
---
V
N
A
I
Q
V
L
P
K
T
K
-
G
-
S
-
V
--
F
Y
G
S
T
D
P
R
K
----------
62
HHSearch
47.03
31%
-30
- C4 -
4GDX
6
?
B:
[7-195]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
A
H
L
S
V
V
A
E
D
G
S
A
V
S
A
T
S
T
I
N
L
Y
F
G
S
K
V
R
--
S
PV
S
--
G
I
--
L
F
N
N
E
M
D
D
F
S
S
P
S
I
T
N-
E
---
F
G
V
P
P
S
P
--------
A
N
F
I
Q
P
G
K
Q
P
L
S
S
M
C
P
T
I
M
V
G
Q
----
D
G
Q
V
R
M
V
V
G
A
A
G
G
T
Q
I
T
T
A
T
A
L
A
I
I
Y
N
L
W
F
G
Y
D
V
K
R
A
V
E
E
P
R
L
H
------
N
Q
L
L
P
N
V
T
T
V
E
R
------------
N
I
D
Q
A
V
T
A
A
L
E
T
R
H
H
H
-----
T
Q
I
---
A
S
T
-
F
I
A
V
---
V
Q
A
I
----
V
R
T
-
A
-
G
-
G
--
W
A
A
A
S
D
S
R
K
G
G
-
E
P
A
G
Y
--
34
PsiBlast_CBE
46.87
31%
-40
- C4 -
3FNM
1
?
D:
[1-187]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
Y
S
V
A
D
R
W
G
N
A
V
S
V
T
Y
T
I
N
A
S
Y
G
S
A
A
S
--
I
--
D
GA
G
F
--
L
L
N
N
E
M
D
D
F
S
I
K
P
---------
G
N
--
P
N
LYGLVGGD
A
N
A
I
E
A
N
K
R
P
L
S
S
M
S
P
T
I
V
L
K
N
N
K
-----
V
F
L
V
V
G
S
P
G
G
S
R
I
I
T
T
V
L
Q
V
I
S
N
V
I
D
Y
N
M
N
I
S
E
A
V
S
--------
A
P
R
F
H
M
Q
W
L
--
P
D
E
L
R
I
E
-------
K
F
G
M
P
A
D
V
K
D
N
L
T
K
M
G
Y
Q
-----
I
V
T
---
K
-
P
-
V
M
G
D
---
V
N
A
I
QVLP
K
T
K
-
G
-
S
-
V
--
F
Y
G
S
T
D
P
R
K
E
---------
61
HHSearch
46.48
38%
-28
- C4 -
2DG5
2
?
B:
[1-190]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
Y
S
V
V
D
K
D
G
N
A
V
A
V
T
Y
T
L
N
T
T
F
G
T
G
I
V
--
A
GE
S
--
G
I
--
L
L
N
N
Q
M
D
D
F
S
A
K
P
G
V
PN
V
---
Y
G
L
V
G
G
D
--------
A
N
A
V
G
P
N
K
R
P
L
S
S
M
S
P
T
I
V
V
K
-----
D
G
K
T
W
L
V
T
G
S
P
G
G
S
R
I
I
T
T
V
L
Q
M
V
V
N
S
I
D
Y
G
L
N
V
A
E
A
T
N
A
P
R
F
H
------
H
Q
W
L
P
D
EL
R
V
E
K
------------
G
F
S
P
D
T
L
K
L
L
E
A
K
G
Q
K
-----
V
A
L
---
K
-
E
-
A
M
G
S
---
T
Q
S
I
----
M
V
G
-
P
-
D
G
E
--
L
Y
G
A
S
D
P
R
S
V
D
D
L
T
A
G
Y
--
74
Fugue
45.16
31%
-21
- C4 -
4GDX
6
?
B:
[7-195]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
A
H
L
S
V
V
A
E
D
G
S
A
V
S
A
T
S
T
I
N
L
Y
F
G
S
K
V
R
SP
V
--
S
--
G
I
--
L
F
N
N
E
M
D
D
F
S
S
P
S
I
T
--
N
EFG
V
P
P
--
S
P
--------
A
N
F
I
Q
P
G
K
Q
P
L
S
S
M
C
P
T
I
M
V
G
Q
D
----
G
Q
V
R
M
V
V
G
A
A
G
G
T
Q
I
T
T
A
T
A
L
A
I
I
Y
N
L
W
F
G
Y
D
V
K
R
A
V
E
------
E
P
R
L
H
N
Q
L
-----
L
P
N
V
T
T
V
-------
E
R
N
I
D
Q
A
V
T
A
A
L
E
T
R
H
H
H
-----
T
Q
I
A
--
S
-
T
-
F
I
A
V
---
V
Q
A
I
----
V
R
T
-
A
-
G
-
G
--
W
A
A
A
S
D
S
R
K
G
G
-
E
P
A
G
Y
--
45
PsiBlast_CBE
44.94
35%
-27
- C4 -
2Z8I
1
?
B:
[1-181]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
Y
S
V
V
D
K
D
G
N
A
V
A
V
T
Y
T
L
N
T
T
F
G
T
G
I
V
--
A
GE
S
--
G
I
--
L
L
N
N
Q
M
D
D
F
S
A
K
P
G
V
--
P
---
N
V
Y
--
G
L
V
G
G
D----
A
N
A
V
G
P
N
K
R
P
L
S
S
M
S
P
T
I
V
V
K
D
-----
G
K
T
W
L
V
T
G
S
P
G
G
S
R
I
I
T
T
V
L
Q
M
V
V
N
S
I
D
Y
G
L
N
V
A
E
--------
A
T
N
A
P
R
F
H
H
Q
W
L
--
P
D
E
L
R
V
E
-------
K
G
F
S
P
D
T
L
-
K
L
L
E
A
K
G
Q
K
-----
V
A
L
---
K
-
E
A
M
G
S
T
---
Q
S
I
M
----
V
G
P
-
D
-
G
-
E
--
L
Y
G
A
S
D
P
R
-----------
42
PsiBlast_CBE
44.61
35%
-29
- C4 -
2Z8J
1
?
D:
[1-181]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
Y
S
V
V
D
K
D
G
N
A
V
A
V
T
Y
T
L
N
T
T
F
G
T
G
I
V
--
A
GE
S
--
G
I
--
L
L
N
N
Q
M
D
D
F
S
A
K
P
G
V
--
P
---
N
V
Y
--
G
L
VGGD----
A
N
A
V
G
P
N
K
R
P
L
S
S
M
S
P
T
I
V
V
K
D
-----
G
K
T
W
L
V
T
G
S
P
G
G
S
R
I
I
T
T
V
L
Q
M
V
V
N
S
I
D
Y
G
L
N
V
A
E
--------
A
T
N
A
P
R
F
H
H
Q
W
L
--
P
D
E
L
R
V
E
-------
K
G
F
S
P
D
T
L
-
K
L
L
E
A
K
G
Q
K
-----
V
A
L
---
K
-
E
A
M
G
S
T
---
Q
S
I
M
----
V
G
P
-
D
-
G
-
E
--
L
Y
G
A
S
D
P
R
-----------
43
PsiBlast_CBE
44.41
35%
-28
- C4 -
2Z8J
1
GGT_ECOLI
B:
[1-181]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
Y
S
V
V
D
K
D
G
N
A
V
A
V
T
Y
T
L
N
T
T
F
G
T
G
I
V
--
A
GE
S
--
G
I
--
L
L
N
N
Q
M
D
D
F
S
A
K
P
G
V
--
P
---
N
V
Y
--
G
L
V
G
G
D----
A
N
A
V
G
P
N
K
R
P
L
S
S
M
S
P
T
I
V
V
K
D
-----
G
K
T
W
L
V
T
G
S
P
G
G
S
R
I
I
T
T
V
L
Q
M
V
V
N
S
I
D
Y
G
L
N
V
A
E
--------
A
T
N
A
P
R
F
H
H
Q
W
L
--
P
D
E
L
R
V
E
-------
K
G
F
S
P
D
T
L
-
K
L
L
E
A
K
G
Q
K
-----
V
A
L
---
K
-
E
A
M
G
S
T
---
Q
S
I
M
----
V
G
P
-
D
-
G
-
E
--
L
Y
G
A
S
D
P
R
-----------
44
PsiBlast_CBE
44.09
35%
-25
- C4 -
2Z8I
1
?
D:
[1-181]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
Y
S
V
V
D
K
D
G
N
A
V
A
V
T
Y
T
L
N
T
T
F
G
T
G
I
V
--
A
GE
S
--
G
I
--
L
L
N
N
Q
M
D
D
F
S
A
K
P
G
V
--
P
---
N
V
Y
--
G
L
VGGD----
A
N
A
V
G
P
N
K
R
P
L
S
S
M
S
P
T
I
V
V
K
D
-----
G
K
T
W
L
V
T
G
S
P
G
G
S
R
I
I
T
T
V
L
Q
M
V
V
N
S
I
D
Y
G
L
N
V
A
E
--------
A
T
N
A
P
R
F
H
H
Q
W
L
--
P
D
E
L
R
V
E
-------
K
G
F
S
P
D
T
L
-
K
L
L
E
A
K
G
Q
K
-----
V
A
L
---
K
-
E
A
M
G
S
T
---
Q
S
I
M
----
V
G
P
-
D
-
G
-
E
--
L
Y
G
A
S
D
P
R
-----------
41
PsiBlast_CBE
44.07
35%
-26
- C4 -
2Z8K
1
?
B:
[1-181]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
Y
S
V
V
D
K
D
G
N
A
V
A
V
T
Y
T
L
N
T
T
F
G
T
G
I
V
--
A
GE
S
--
G
I
--
L
L
N
N
Q
M
D
D
F
S
A
K
P
G
V
--
P
---
N
V
Y
--
G
L
V
G
G
D----
A
N
A
V
G
P
N
K
R
P
L
S
S
M
S
P
T
I
V
V
K
D
-----
G
K
T
W
L
V
T
G
S
P
G
G
S
R
I
I
T
T
V
L
Q
M
V
V
N
S
I
D
Y
G
L
N
V
A
E
--------
A
T
N
A
P
R
F
H
H
Q
W
L
--
P
D
E
L
R
V
E
-------
K
G
F
S
P
D
T
L
-
K
L
L
E
A
K
G
Q
K
-----
V
A
L
---
K
-
E
A
M
G
S
T
---
Q
S
I
M
----
V
G
P
-
D
-
G
-
E
--
L
Y
G
A
S
D
P
R
-----------
40
PsiBlast_CBE
43.66
35%
-28
- C4 -
2Z8K
1
?
D:
[1-181]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
Y
S
V
V
D
K
D
G
N
A
V
A
V
T
Y
T
L
N
T
T
F
G
T
G
I
V
--
A
GE
S
--
G
I
--
L
L
N
N
Q
M
D
D
F
S
A
K
P
G
V
--
P
---
N
V
Y
--
G
L
VGGD----
A
N
A
V
G
P
N
K
R
P
L
S
S
M
S
P
T
I
V
V
K
D
-----
G
K
T
W
L
V
T
G
S
P
G
G
S
R
I
I
T
T
V
L
Q
M
V
V
N
S
I
D
Y
G
L
N
V
A
E
--------
A
T
N
A
P
R
F
H
H
Q
W
L
--
P
D
E
L
R
V
E
-------
K
G
F
S
P
D
T
L
-
K
L
L
E
A
K
G
Q
K
-----
V
A
L
---
K
-
E
A
M
G
S
T
---
Q
S
I
M
----
V
G
P
-
D
-
G
-
E
--
L
Y
G
A
S
D
P
R
-----------
46
PsiBlast_CBE
43.14
31%
-32
- C4 -
3WHS
1
?
B:
[1-179]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
F
T
V
A
D
R
W
G
N
V
V
S
Y
T
T
T
I
E
Q
L
F
G
T
G
I
M
--
V
--
P
DY
G
V
--
I
L
N
N
E
L
T
D
F
D
A
I
P
G
G
---------------------
A
N
E
V
Q
P
N
K
R
P
L
S
S
M
T
P
T
I
L
F
K
D
D
K
P
-----
V
L
T
V
G
S
P
G
G
A
T
I
I
S
S
V
L
Q
T
I
L
Y
H
I
E
Y
G
M
E
L
K
A
A
V
-----------------
E
--
E
P
R
I
Y
T
N
SMS
S
Y
R
Y
E
D
G
V
P
K
D
V
L
S
K
L
N
G
M
G
H
K
-----
F
G
T
---
S
-
P
-
V
D
I
G
N
V
Q
S
I
S
I
----
D
H
E
-
N
-
G
-
T
--
F
K
G
V
A
D
S
S
R
N
G
-
A
A
I
G
---
48
PsiBlast_CBE
41.95
31%
-33
- C4 -
3A75
1
?
B:
[1-179]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
F
T
V
A
D
R
W
G
N
V
V
S
Y
T
T
T
I
E
Q
L
F
G
T
G
I
M
--
V
--
P
DY
G
V
--
I
L
N
N
E
L
T
D
F
D
A
I
P
G
G
---------------------
A
N
E
V
Q
P
N
K
R
P
L
S
S
M
T
P
T
I
L
F
K
D
D
K
P
-----
V
L
T
V
G
S
P
G
G
A
T
I
I
S
S
V
L
Q
T
I
L
Y
H
I
E
Y
G
M
E
L
K
A
A
V
-----------------
E
--
E
P
R
I
Y
T
N
SMS
S
Y
R
Y
E
D
G
V
P
K
D
V
L
S
K
L
N
G
M
G
H
K
-----
F
G
T
---
S
-
P
-
V
D
I
G
N
V
Q
S
I
S
I
----
D
H
E
-
N
-
G
-
T
--
F
K
G
V
A
D
S
S
R
N
G
-
A
A
I
G
---
47
PsiBlast_CBE
41.45
31%
-36
- C4 -
3A75
1
?
D:
[1-179]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
F
T
V
A
D
R
W
G
N
V
V
S
Y
T
T
T
I
E
Q
L
F
G
T
G
I
M
--
V
--
P
DY
G
V
--
I
L
N
N
E
L
T
D
F
D
A
I
P
G
G
---------------------
A
N
E
V
Q
P
N
K
R
P
L
S
S
M
T
P
T
I
L
F
K
D
D
K
P
-----
V
L
T
V
G
S
P
G
G
A
T
I
I
S
S
V
L
Q
T
I
L
Y
H
I
E
Y
G
M
E
L
K
A
A
V
-----------------
E
--
E
P
R
I
Y
T
N
SMSSYRY
E
D
G
V
P
K
D
V
L
S
K
L
N
G
M
G
H
K
-----
F
G
T
---
S
-
P
-
V
D
I
G
NVQ
S
I
S
I
----
D
H
E
-
N
-
G
-
T
--
F
K
G
V
A
D
S
S
R
N
G
-
A
A
I
G
---
49
PsiBlast_CBE
39.16
32%
-24
- C4 -
4OTU
2
?
B:
[1-179]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
F
T
V
T
D
Q
W
G
N
V
V
S
Y
T
T
T
I
E
Q
L
F
G
T
G
I
L
--
V
--
P
--
G
Y
G
L
F
L
N
N
E
L
T
D
F
D
A
I
P
G
G
---------------------
A
N
E
V
Q
P
N
K
R
P
L
S
S
M
T
P
T
I
V
F
K
D
E
K
P
-----
V
L
T
V
G
S
P
G
G
T
T
I
I
A
S
V
F
Q
T
I
L
N
Y
F
E
Y
G
M
S
L
Q
D
A
I
-----------------
E
--
E
P
R
I
Y
T
N
SLT
S
Y
R
Y
E
S
G
M
P
E
D
V
R
R
K
L
N
D
F
G
H
K
F
G
S
N
P
V
D
I
---
G
-
N
-
V
Q
S
I
---
F
--
I
----
D
R
E
-
N
-
K
-
T
--
F
M
G
V
A
D
S
S
R
N
G
-
T
A
V
G
---
63
HHSearch
38.14
30%
-28
- C4 -
3G9K
2
?
S:
[1-175]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
H
F
V
I
I
D
R
D
G
T
V
V
S
S
T
N
T
L
S
N
F
F
G
T
G
K
Y
--
T
--
A
--
G
F
--
F
L
N
N
Q
L
Q
N
---------------------------------
P
G
K
R
S
R
T
F
M
A
P
T
V
L
K
K
-----
D
G
E
-
T
I
G
I
G
S
P
G
G
N
R
I
P
Q
I
L
T
P
I
L
D
K
Y
T
H
G
K
G
S
L
Q
D
I
I
N
E
Y
R
F
T
------
F
E
K
N
-
T
A-
Y
T
E
I
------------
Q
L
S
S
E
V
K
N
E
L
S
R
K
G
L
N
-----
V
K
K
KVS
P
-
A
-
F
F
G
G
---
V
Q
A
L
----
I
K
D
E
R
-
D
N
V
--
I
T
G
A
G
D
G
R
R
N
G
-
T
W
K
S
---