@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2870c: (2016-05-14 )
MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPGAAGRHASTLERS
Atome Classification :
(83 SA)
.........10........20........30....---....40........50........60........70---..--------......----------.80-..---------......90........100.......110.......120.......130......---.140---.--...--...150.......160-------....----------.-------------..----.170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.....-..360.-.-.....---370.......380.......390.......400.......410.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTNSTDGRAD
G
R
L
R
V
V
V
LGSTGS
I
G
T
Q
A
L
Q
V
IADN---PD
R
F
E
V
V
G
LAAG
G
A
H
L
D
T
L
L
R
Q
R
A
QTGV
T
N
I
A
VA
D
----
E
H
--------
A
A
Q
RVG----------DIP-YH---------G
S
D
A
A
T
R
L
V
E
QT
E
A
D
V
V
L
N
A
L
V
G
ALGL
R
P
T
L
A
A
L
KTG
A
R
L
ALAN
K
E
S
LVAG
G
S
L
V
---
L
R
AA---R--PG
Q
--
I
V
PVD
S
E
H
S
A
L
A
Q
C
L
--------RGG
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
TASGGPFRGWSAADLEHVT
P
E
QAGAHPTWSMGPMNTL
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
LFGI
P
Y
D
R
I
D
V
V
VH
P
Q
S
I
I
H
S
M
V
T
FIDGSTIAQASPPD
M
K
L
P
I
S
L
ALGWPRRVSG
A
A
A
A
C
D
FHTASSWEFEPLDTD
V
F
P
A
V
E
L
A
R
QAGVA
G
G
C
M
T
A
V
YNAA
N
E
E
A
A
A
A
F
L
AGRI
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
QWAV-E-P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
A
S
V
A
I
ASTAKPGAAGRHASTLERS
21
PsiBlast_CBE
98.86
100%
-116
- C5 -
2C82
1
DXR_MYCTU
B:
[11-389]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
1
PsiBlast_PDB
98.72
100%
-115
- C5 -
2C82
1
DXR_MYCTU
A:
[11-389]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
28
PsiBlast_CBE
98.05
99%
-115
- C5 -
2Y1E
2
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
43
PsiBlast_CBE
97.99
99%
-115
- C5 -
2JCY
1
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
26
PsiBlast_CBE
97.92
99%
-117
- C5 -
2Y1G
2
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
32
PsiBlast_CBE
97.73
99%
-115
- C5 -
2JD1
2
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
31
PsiBlast_CBE
97.67
99%
-114
- C5 -
2JD2
2
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
41
PsiBlast_CBE
97.55
99%
-114
- C5 -
2JD0
1
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
33
PsiBlast_CBE
97.47
99%
-115
- C5 -
2JCV
2
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
45
PsiBlast_CBE
97.45
99%
-116
- C5 -
2JCX
2
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
23
PsiBlast_CBE
97.11
99%
-116
- C5 -
4AIC
3
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
29
PsiBlast_CBE
96.70
99%
-111
- C5 -
2Y1D
1
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
27
PsiBlast_CBE
96.70
99%
-115
- C5 -
2Y1F
3
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
6
PsiBlast_PDB
96.59
99%
-112
- C5 -
3RAS
4
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
30
PsiBlast_CBE
96.57
99%
-114
- C5 -
2Y1C
1
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
20
PsiBlast_PDB
96.42
99%
-111
- C5 -
2JCX
3
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
25
PsiBlast_CBE
96.40
99%
-116
- C5 -
3RAS
5
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
34
PsiBlast_CBE
96.36
99%
-115
- C5 -
3ZI0
1
DXR_MYCTU
B:
[20-397]
-----------
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
-----
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
13
PsiBlast_PDB
96.28
99%
-112
- C5 -
4AIC
4
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
44
PsiBlast_CBE
96.09
99%
-114
- C5 -
2JCY
2
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
24
PsiBlast_CBE
96.06
99%
-112
- C5 -
4A03
3
DXR_MYCTU
B:
[20-397]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
-------------------------
17
PsiBlast_PDB
96.03
99%
-113
- C5 -
3ZHX
2
DXR_MYCTU
A:
[19-397]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
-------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
2
PsiBlast_PDB
96.01
100%
-116
- C5 -
4RCV
4
DXR_MYCTU
A:
[27-404]
-----------
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
3
PsiBlast_PDB
95.83
99%
-109
- C5 -
2JCV
3
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
10
PsiBlast_PDB
95.64
99%
-114
- C5 -
2Y1F
4
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
------
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
11
PsiBlast_PDB
95.46
99%
-113
- C5 -
2Y1G
4
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
4
PsiBlast_PDB
95.22
99%
-109
- C5 -
2JD1
4
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
42
PsiBlast_CBE
95.09
99%
-111
- C5 -
2JD0
3
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
12
PsiBlast_PDB
94.99
99%
-111
- C5 -
4A03
4
DXR_MYCTU
A:
[20-397]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
-------------------------
22
PsiBlast_CBE
94.82
100%
-113
- C5 -
4RCV
3
DXR_MYCTU
B:
[26-404]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
--
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
40
PsiBlast_CBE
94.68
99%
-111
- C5 -
4OOF
3
DXR_MYCTU
B:
[25-402]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
F
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
-------------------------
19
PsiBlast_PDB
94.45
99%
-110
- C5 -
4OOF
3
DXR_MYCTU
A:
[25-402]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
F
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
-------------------------
15
PsiBlast_PDB
94.32
99%
-113
- C5 -
3ZHZ
1
DXR_MYCTU
A:
[19-397]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
-------------------------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
-------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
16
PsiBlast_PDB
94.08
99%
-113
- C5 -
3ZHY
3
DXR_MYCTU
A:
[19-396]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
-------------------------
14
PsiBlast_PDB
93.24
99%
-120
- C5 -
3ZI0
1
DXR_MYCTU
A:
[20-395]
-----------
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
---------------------------------
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
--------------------------
8
PsiBlast_PDB
92.81
99%
-116
- C5 -
2Y1D
2
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
--------------------------------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
----------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
35
PsiBlast_CBE
92.38
99%
-114
- C5 -
3ZHY
3
DXR_MYCTU
B:
[19-396]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
----
E
H
--------
A
A
Q
R
V
G
----------
D
I
P
-
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
---
L
R
A
A
---
R
--
P
G
Q
--
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------
R
G
G
T
----------
P
-------------
D
E
----
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
-
A
D
Q
W
A
V
-
E
-
P
A
T
V
D
---
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
-------------------------
47
PsiBlast_CBE
73.00
42%
-107
- C5 -
4ZN6
4
DXR_ACIB3
A:
[13-404]
--------------
V
C
I
L
G
V
T
G
S
I
G
R
S
T
L
K
I
L
G
Q
H
---
P
D
K
Y
S
V
F
A
V
S
A
H
-
S
R
I
S
E
L
V
E
I
C
K
Q
F
R
P
K
V
V
V
V
P
E
----
Q
K
I
A
E
L
K
T
L
F
A
Q
Q
N
I
S
----------
D
I
D
V
L
A
---------
G
Q
E
G
L
V
D
I
A
S
H
T
D
V
D
I
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
V
K
A
G
K
R
V
L
L
A
N
K
E
A
L
V
M
S
G
E
I
M
---
M
Q
A
A
---
R
--
D
H
Q
A
L
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PHNYLQAD
R
T
G
Q
----------
P
-------------
Q
L
G---
V
S
K
I
L
L
T
A
S
G
G
P
F
L
N
H
S
L
E
Q
L
V
H
V
T
P
Q
Q
A
C
K
-----
M
G
Q
K
I
S
V
D
S
A
T
L
M
N
K
G
L
E
L
I
E
A
C
H
L
F
S
I
S
E
H
F
V
T
V
V
V
H
P
Q
S
I
I
H
S
M
V
Q
Y
V
D
G
S
T
L
A
Q
M
G
N
P
D
M
C
T
P
I
A
H
A
L
A
W
P
E
R
L
Q
T
N
V
P
A
L
D
L
F
E
Y
S
Q
L
N
F
Q
A
P
D
T
Q
K
F
P
A
L
N
L
A
R
Q
A
M
R
A
G
G
L
A
P
T
I
L
N
A
A
N
E
I
A
V
E
A
F
L
M
E
R
I
G
F
T
S
I
P
Q
V
V
E
H
T
L
E
K
-
L
E
N
A
A
A
-
E
---
S
I
E
---
C
I
L
D
K
D
K
V
A
R
S
V
A
Q
Q
Y
I
S
S
I
------------------------
86
PsiBlast_CBE
72.86
34%
-105
- C5 -
3AU8
2
DXR_PLAFX
B:
[78-478]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
K
P
I
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
L
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
---
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
103
HHSearch
72.79
35%
-97
- C5 -
4Y67
2
DXR_PLAF7
A:
[11-420]
-----------
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
-
N
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
----
K
S
--------
V
Y
E
E
L
K
E
L
V
K
N
IKDYK
P
I
I
-
L
C
---------
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
---
K
K
L
L
N
I
H
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
L
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
E
N
S
E
D
L
M
K
---
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
N
-----------------------
102
HHSearch
72.00
42%
-102
* C5 *
4ZN6
4
DXR_ACIB3
A:
[10-404]
-----------
T
Q
S
V
C
I
L
G
V
T
G
S
I
G
R
S
T
L
K
I
L
G
Q
H
---
P
D
K
Y
S
V
F
A
V
S
A
-
H
S
R
I
S
E
L
V
E
I
C
K
Q
F
R
P
K
V
V
V
V
P
E
----
Q
K
---------
I
A
E
L
K
T
L
F
A
Q
Q
NISD
I
D
V
-
L
A
---------
G
Q
E
G
L
V
D
I
A
S
H
T
D
V
D
I
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
V
K
A
G
K
R
V
L
L
A
N
K
E
A
L
V
M
S
G
E
I
M
---
M
Q
A
A
R
D
-
H
--
Q
A
L
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
--------
P
H
N
Y
LQADRTGQP-
Q
-------------
L
G
----
V
S
K
I
L
L
T
A
S
G
G
P
F
L
N
H
S
L
E
Q
L
V
H
V
T
P
Q
Q
A
C
K
-----
M
G
Q
K
I
S
V
D
S
A
T
L
M
N
K
G
L
E
L
I
E
A
C
H
L
F
S
I
S
E
H
F
V
T
V
V
V
H
P
Q
S
I
I
H
S
M
V
Q
Y
V
D
G
S
T
L
A
Q
M
G
N
P
D
M
C
T
P
I
A
H
A
L
A
W
P
E
R
L
Q
T
N
V
P
A
L
D
L
F
E
Y
S
Q
L
N
F
Q
A
P
D
T
Q
K
F
P
A
L
N
L
A
R
Q
A
M
R
A
G
G
L
A
P
T
I
L
N
A
A
N
E
I
A
V
E
A
F
L
M
E
R
I
G
F
T
S
I
P
Q
V
V
E
H
T
L
E
K
L
E
N
A
----
A
-
A
E
S
I
E
---
C
I
L
D
K
D
K
V
A
R
S
V
A
Q
Q
Y
I
S
S
I
------------------------
96
PsiBlast_CBE
71.15
33%
-99
- C5 -
4KP7
3
DXR_PLAFX
A:
[16-417]
-----------
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPI
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
L
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
90
PsiBlast_CBE
70.82
34%
-98
- C5 -
4Y6R
3
DXR_PLAF7
A:
[12-412]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPI
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
L
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
93
PsiBlast_CBE
70.76
34%
-98
- C5 -
4Y67
2
DXR_PLAF7
B:
[12-412]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
NKI
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSVY
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPIILC---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
KKL
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
LKTKCLQDNFSKI
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
LMK
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
78
PsiBlast_CBE
70.62
34%
-98
- C5 -
3WQR
5
DXR_PLAFX
B:
[78-478]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
NKI
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSVY
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPIILC---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
KKL
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
LKTKCLQDNFSKI
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
LMK
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
98
PsiBlast_CBE
70.55
34%
-98
- C5 -
4GAE
7
DXR_PLAFX
A:
[16-416]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPI
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
I
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
89
PsiBlast_CBE
70.52
34%
-99
- C5 -
4Y6R
3
DXR_PLAF7
B:
[12-412]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
NKI
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSVY
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPIILC---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
KKL
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
LKTKCLQDNFSKI
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
LMK
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
95
PsiBlast_CBE
70.51
33%
-101
- C5 -
4KP7
2
DXR_PLAFX
B:
[16-417]
-----------
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPI
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
L
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
------
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
79
PsiBlast_CBE
70.50
34%
-97
- C5 -
3WQR
4
DXR_PLAFX
A:
[78-478]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPI
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
L
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
94
PsiBlast_CBE
70.31
34%
-99
- C5 -
4Y67
2
DXR_PLAF7
A:
[12-412]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPI
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
L
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
91
PsiBlast_CBE
70.26
34%
-99
- C5 -
4Y6P
4
DXR_PLAF7
B:
[12-412]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
NKI
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSVY
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPIILC---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
KKL
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
LKTKCLQDNFSKI
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
LMK
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
82
PsiBlast_CBE
70.03
34%
-96
- C5 -
3AUA
5
DXR_PLAFX
B:
[78-478]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
NKI
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSVY
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPIILC---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
KKL
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
LKTKCLQDNFSKI
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
LMK
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
83
PsiBlast_CBE
70.02
34%
-95
- C5 -
3AUA
4
DXR_PLAFX
A:
[78-478]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPI
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
L
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
80
PsiBlast_CBE
69.91
34%
-96
- C5 -
3WQQ
5
DXR_PLAFX
B:
[78-478]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
NKI
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSVY
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPIILC---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
KKL
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
LKTKCLQDNFSKI
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
LMK
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
97
PsiBlast_CBE
69.83
34%
-98
- C5 -
4GAE
9
DXR_PLAFX
B:
[16-416]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
K
P
I
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
I
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
75
PsiBlast_CBE
69.77
40%
-99
- C5 -
3R0I
2
DXR_ECOLI
B:
[15-410]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
QGSRTEVLS
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
QS
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQH--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
-----
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
88
PsiBlast_CBE
69.75
34%
-98
- C5 -
4Y6S
2
DXR_PLAF7
A:
[12-412]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPI
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
L
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
81
PsiBlast_CBE
69.73
34%
-96
- C5 -
3WQQ
4
DXR_PLAFX
A:
[78-478]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPI
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
L
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
84
PsiBlast_CBE
69.66
34%
-97
- C5 -
3AU9
5
DXR_PLAFX
B:
[78-478]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
NKI
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSVY
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPIILC---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
KKL
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
LKTKCLQDNFSKI
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
LMK
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
85
PsiBlast_CBE
69.62
34%
-97
- C5 -
3AU9
4
DXR_PLAFX
A:
[78-478]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPI
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
L
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
101
HHSearch
69.58
42%
-88
- C5 -
1Q0Q
2
DXR_ECOLI
A:
[9-405]
-----------
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
-
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
T
M
L
Q
Q
Q
GSR-
T
E
V
-
L
S
---------
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
K
Q
-
S
--
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
--------
P
Q
P
I
Q
H
N
LGYADLE
Q
-------------
N
G
----
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
----
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-----------------------
92
PsiBlast_CBE
69.39
34%
-96
- C5 -
4Y6P
3
DXR_PLAF7
A:
[12-412]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSV
Y
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPI
I
L
C
---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
L
K
TKCLQDN
F
S
K
I
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
87
PsiBlast_CBE
69.34
34%
-98
- C5 -
4Y6S
2
DXR_PLAF7
B:
[12-412]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
NKI
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSVY
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPIILC---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
KKL
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
LKTKCLQDNFSKI
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
LMK
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
76
PsiBlast_CBE
69.15
40%
-98
- C5 -
3R0I
2
DXR_ECOLI
A:
[15-410]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
Q
GSR
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
Q
S
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
-----
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
77
PsiBlast_CBE
69.02
34%
-95
- C5 -
3WQS
3
DXR_PLAFX
B:
[78-478]
------------
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
NKI
E
N
V
F
N
V
K
A
L
Y
V
N
K
S
-
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
KSVY
E
E
--------
L
K
E
L
V
K
----------
N
I
K
-
D
Y
KPIILC---
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
KKL
L
N
I
H
---
K
--
N
A
K
--
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------
D
N
N
K
----------
V
LKTKCLQDNFSKI
N
N
----
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
-
F
N
S
Q
K
V
-
S
-
E
N
S
E
D
LMK
Q
I
L
Q
I
H
S
W
A
K
D
K
A
-------------------------------
58
PsiBlast_CBE
68.63
40%
-91
- C5 -
1Q0Q
2
DXR_ECOLI
B:
[9-406]
-----------
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
QGSRTEVLS
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
QS
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQH--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
64
PsiBlast_CBE
68.56
39%
-91
- C5 -
3ANM
2
DXR_ECOLI
A:
[13-410]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
Q
GSR
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
Q
S
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
S
A
----------------
62
PsiBlast_CBE
68.39
39%
-92
- C5 -
3ANN
2
DXR_ECOLI
A:
[13-410]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
Q
GSR
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
Q
S
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
S
A
----------------
107
HHSearch
68.26
36%
-93
- C5 -
3A06
4
DXR_THEMA
A:
[3-372]
-----------
E
R
T
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
K
K
V
----
K
G
I
R
L
I
G
I
S
F
-
H
S
N
L
E
L
A
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
G
----
D
V
--------
E
F
E
D
S
S
----------
I
N
V
-
W
K
---------
G
S
H
S
I
E
E
M
L
E
A
L
K
P
D
I
T
M
V
A
V
S
G
F
S
G
L
R
A
V
L
A
S
L
E
H
S
K
R
V
C
L
A
N
K
E
S
L
V
C
G
G
F
L
V
---
K
K
K
L
K
E
-
K
--
G
T
E
--
L
I
P
V
D
S
E
H
S
A
I
F
Q
V
M
--------
E
P
---------------------------
E
----
V
E
K
V
V
L
T
A
S
G
G
A
L
R
D
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
K
H
P
V
W
N
M
G
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
F
Y
P
R
R
V
A
L
E
--
P
-
F
F
L
R
T
I
S
L
S
F
E
D
P
D
P
E
K
Y
P
A
F
F
L
L
K
E
I
K
D
-
S
Y
A
L
R
T
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
E
E
F
Q
G
Y
--
P
-
Q
-
P
R
T
L
D
---
D
V
E
R
I
H
F
E
A
I
K
K
A
E
R
V
T
E
W
L
S
-----------------------
59
PsiBlast_CBE
68.26
40%
-91
- C5 -
1Q0Q
2
DXR_ECOLI
A:
[9-406]
-----------
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
Q
GSR
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
Q
S
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
69
PsiBlast_CBE
68.20
40%
-93
- C5 -
1T1R
2
DXR_ECOLI
B:
[3-398]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
QGSRTEVLS
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
QS
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQH--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
68
PsiBlast_CBE
68.14
40%
-94
- C5 -
1T1S
3
DXR_ECOLI
A:
[3-398]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
Q
GSR
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
Q
S
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
63
PsiBlast_CBE
68.06
39%
-92
- C5 -
3ANM
2
DXR_ECOLI
B:
[13-408]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
QGSRTEVLS
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
QS
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQH--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
57
PsiBlast_CBE
68.03
39%
-92
- C5 -
2EGH
3
DXR_ECOLI
A:
[13-410]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
Q
GSR
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
Q
S
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
S
A
----------------
60
PsiBlast_CBE
67.79
40%
-88
- C5 -
1Q0L
2
DXR_ECOLI
A:
[9-406]
-----------
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
Q
GSR
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
Q
S
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
56
PsiBlast_CBE
67.64
39%
-89
- C5 -
2EGH
3
DXR_ECOLI
B:
[13-408]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
QGSRTEVLS
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
QS
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQH--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
61
PsiBlast_CBE
67.40
39%
-91
- C5 -
3ANN
2
DXR_ECOLI
B:
[13-408]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
QGSRTEVLS
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
QS
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQH--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
70
PsiBlast_CBE
67.27
40%
-92
- C5 -
1T1R
2
DXR_ECOLI
A:
[3-398]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
Q
GSR
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
Q
S
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
71
PsiBlast_CBE
67.17
40%
-94
- C5 -
1ONP
2
DXR_ECOLI
B:
[3-397]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
QGSRTEVLS
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
QS
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQH--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-----------------------
72
PsiBlast_CBE
67.13
40%
-95
- C5 -
1ONP
2
DXR_ECOLI
A:
[3-397]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
Q
GSR
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
Q
S
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-----------------------
65
PsiBlast_CBE
67.09
39%
-92
- C5 -
3ANL
2
DXR_ECOLI
B:
[13-408]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
QGSRTEVLS
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
QS
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQH--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
67
PsiBlast_CBE
66.98
40%
-92
- C5 -
1T1S
2
DXR_ECOLI
B:
[3-398]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
QGSRTEVLS
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
QS
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQH--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----------------------
66
PsiBlast_CBE
66.84
39%
-91
- C5 -
3ANL
2
DXR_ECOLI
A:
[13-410]
-------------
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
----
E
A
--------
S
A
K
L
L
K
----------
T
M
L
-
Q
Q
Q
GSR
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
---
M
D
A
V
---
K
Q
S
K
A
Q
--
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
--
N
L
G
Y
----------
A
-------------
D
L
EQNG
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
-
M
D
M
R
---
E
-
P
Q
C
V
D
---
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
S
A
----------------