@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2995c: (2016-05-15 )
MKLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVADAFERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLATRGSERLATSDVGERIAAAL
Atome Classification :
(52 SA)
------------------.........10........20..----.....-------.----30.....----.-----..---40...-.-....50.......-.60.........70-.---.----.---.----....80.-----.......90........100...--.--.--..110--.---.--......120.......130.......-------------------140....-----...150.----......160.......------------170-------------........180.......---190.....---..200--------------------------------.......210.......220.......230.......240.......250.......260.......270.......280.......290.....-.-.300.......310---------.---------..-----------.--------...320..-------.....330....---------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------
M
K
L
A
I
I
AGDGI
G
P
E
V
T
A
E
A
V
K
V
L
----
D
A
VVP-------G----VQKTSYD----L-----G
A
---
R
R
FHA-T-GEVL
P
D
S
V
V
A
E
L
R-NH-
D
A
I
L
L
GAIGDP-S---V----
P
---
S
----
G
V
L
E
RG
L
-----
L
L
R
L
R
F
ELDHHINL
R
P
A
RLYPGV--A--S--PLSG---N---P--G
I
D
F
V
V
V
REGTEGPYTGNG
G
A
I
R
VGT-------------------PNE
V
A
T
E
-----
V
S
V
N
T
A
F
----
G
V
R
R
V
V
A
D
A
F
E
R
A
R
R
R------------R-K-------------
H
L
T
L
V
H
KT
N
V
L
T
FAGG
L
W
---
L
R
T
V
D
E
V
G
---
E
CYP
D
--------------------------------
V
E
V
A
Y
Q
HV
D
A
A
T
I
H
M
ITDP
G
R
F
D
V
I
VTD
N
L
F
G
D
I
I
T
D
L
A
A
A
V
CGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIA
D
P
T
A
A
I
M
S
V
A
L
L
L
S
H-L-GE
H
D
A
A
A
R
V
D
R
A
V
E
---------
A
---------
H
L
-----------A--------TRGSERL
A
-------
T
S
D
V
G
E
R
I
A
AAL---------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
99.67
100%
-113
- C5 -
2G4O
1
LEU3_MYCTU
C:
[3-337]
-------------------
K
L
A
I
I
A
G
D
G
I
G
P
E
V
T
A
E
A
V
K
V
L
----
D
A
V
V
P
-------
G
----
V
Q
K
T
S
Y
D
----
L
-----
G
A
---
R
R
F
H
A
-
T
-
G
E
V
L
P
D
S
V
V
A
E
L
R
-
N
H
-
D
A
I
L
L
G
A
I
G
D
P
-
S
---
V
----
P
---
S
----
G
V
L
E
R
G
L
-----
L
L
R
L
R
F
E
L
D
H
H
I
N
L
R
P
A
R
L
Y
P
G
V
--
A
--
S
--
P
L
S
G
---
N
---
P
--
G
I
D
F
V
V
V
R
E
G
T
E
G
P
Y
T
G
N
G
G
A
I
R
V
G
T
-------------------
P
N
E
V
A
T
E
-----
V
S
V
N
T
A
F
----
G
V
R
R
V
V
A
D
A
F
E
R
A
R
R
R
------------
R
-
K
-------------
H
L
T
L
V
H
K
T
N
V
L
T
F
A
G
G
L
W
---
L
R
T
V
D
E
V
G
---
E
C
Y
P
D
--------------------------------
V
E
V
A
Y
Q
H
V
D
A
A
T
I
H
M
I
T
D
P
G
R
F
D
V
I
V
T
D
N
L
F
G
D
I
I
T
D
L
A
A
A
V
C
G
G
I
G
L
A
A
S
G
N
I
D
A
T
R
A
N
P
S
M
F
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
I
A
D
P
T
A
A
I
M
S
V
A
L
L
L
S
H
-
L
-
G
E
H
D
A
A
A
R
V
D
R
A
V
E
---------
A
---------
H
L
-----------
A
--------
T
R
G
S
E
R
L
A
-------
T
S
D
V
G
E
R
I
A
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
98.54
100%
-109
- C5 -
2G4O
4
LEU3_MYCTU
A:
[3-337]
-------------------
K
L
A
I
I
A
G
D
G
I
G
P
E
V
T
A
E
A
V
K
V
L
----
D
A
V
V
P
-------
G
----
V
Q
K
T
S
Y
D
----
L
-----
G
A
---
R
R
F
H
A
-
T
-
G
E
V
L
P
D
S
V
V
A
E
L
R
-
N
H
-
D
A
I
L
L
G
A
I
G
D
P
-
S
---
V
----
P
---
S
----
G
V
L
E
R
G
L
-----
L
L
R
L
R
F
E
L
D
H
H
I
N
L
R
P
A
R
L
Y
P
G
V
--
A
--
S
--
P
L
S
G
---
N
---
P
--
G
I
D
F
V
V
V
R
E
G
T
E
G
P
Y
T
G
N
G
G
A
I
R
V
G
T
-------------------
P
N
E
V
A
T
E
-----
V
S
V
N
T
A
F
----
G
V
R
R
V
V
A
D
A
F
E
R
A
R
R
R
------------
R
-
K
-------------
H
L
T
L
V
H
K
T
N
V
L
T
F
A
G
G
L
W
---
L
R
T
V
D
E
V
G
---
E
C
Y
P
D
--------------------------------
V
E
V
A
Y
Q
H
V
D
A
A
T
I
H
M
I
T
D
P
G
R
F
D
V
I
V
T
D
N
L
F
G
D
I
I
T
D
L
A
A
A
V
C
G
G
I
G
L
A
A
S
G
N
I
D
A
T
R
A
N
P
S
M
F
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
I
A
D
P
T
A
A
I
M
S
V
A
L
L
L
S
H
-
L
-
G
E
H
D
A
A
A
R
V
D
R
A
V
E
---------
A
---------
H
L
-----------
A
--------
T
R
G
S
E
R
L
A
-------
T
S
D
V
G
E
R
I
A
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
98.01
100%
-109
- C5 -
2G4O
2
LEU3_MYCTU
D:
[3-337]
-------------------
K
L
A
I
I
A
G
D
G
I
G
P
E
V
T
A
E
A
V
K
V
L
----
D
A
V
V
P
-------
G
----
V
Q
K
T
S
Y
D
----
L
-----
G
A
---
R
R
F
H
A
-
T
-
G
E
V
L
P
D
S
V
V
A
E
L
R
-
N
H
-
D
A
I
L
L
G
A
I
G
D
P
-
S
---
V
----
P
---
S
----
G
V
L
E
R
G
L
-----
L
L
R
L
R
F
E
L
D
H
H
I
N
L
R
P
A
R
L
Y
P
G
V
--
A
--
S
--
P
L
S
G
---
N
---
P
--
G
I
D
F
V
V
V
R
E
G
T
E
G
P
Y
T
G
N
G
G
A
I
R
V
G
T
-------------------
P
N
E
V
A
T
E
-----
V
S
V
N
T
A
F
----
G
V
R
R
V
V
A
D
A
F
E
R
A
R
R
R
------------
R
-
K
-------------
H
L
T
L
V
H
K
T
N
V
L
T
F
A
G
G
L
W
---
L
R
T
V
D
E
V
G
---
E
C
Y
P
D
--------------------------------
V
E
V
A
Y
Q
H
V
D
A
A
T
I
H
M
I
T
D
P
G
R
F
D
V
I
V
T
D
N
L
F
G
D
I
I
T
D
L
A
A
A
V
C
G
G
I
G
L
A
A
S
G
N
I
D
A
T
R
A
N
P
S
M
F
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
I
A
D
P
T
A
A
I
M
S
V
A
L
L
L
S
H
-
L
-
G
E
H
D
A
A
A
R
V
D
R
A
V
E
---------
A
---------
H
L
-----------
A
--------
T
R
G
S
E
R
L
A
-------
T
S
D
V
G
E
R
I
A
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
97.98
100%
-108
- C5 -
1W0D
-
LEU3_MYCTU
A:
[2-336]
------------------
S
K
L
A
I
I
A
G
D
G
I
G
P
E
V
T
A
E
A
V
K
V
L
----
D
A
V
V
P
-------
G
----
V
Q
K
T
S
Y
D
----
L
-----
G
A
---
R
R
F
H
A
-
T
-
G
E
V
L
P
D
S
V
V
A
E
L
R
-
N
H
-
D
A
I
L
L
G
A
I
G
D
P
-
S
---
V
----
P
---
S
----
G
V
L
E
R
G
L
-----
L
L
R
L
R
F
E
L
D
H
H
I
N
L
R
P
A
R
L
Y
P
G
V
--
A
--
S
--
P
L
S
G
---
N
---
P
--
G
I
D
F
V
V
V
R
E
G
T
E
G
P
Y
T
G
N
G
G
A
I
R
V
G
T
-------------------
P
N
E
V
A
T
E
-----
V
S
V
N
T
A
F
----
G
V
R
R
V
V
A
D
A
F
E
R
A
R
R
R
------------
R
-
K
-------------
H
L
T
L
V
H
K
T
N
V
L
T
F
A
G
G
L
W
---
L
R
T
V
D
E
V
G
---
E
C
Y
P
D
--------------------------------
V
E
V
A
Y
Q
H
V
D
A
A
T
I
H
M
I
T
D
P
G
R
F
D
V
I
V
T
D
N
L
F
G
D
I
I
T
D
L
A
A
A
V
C
G
G
I
G
L
A
A
S
G
N
I
D
A
T
R
A
N
P
S
M
F
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
I
A
D
P
T
A
A
I
M
S
V
A
L
L
L
S
H
-
L
-
G
E
H
D
A
A
A
R
V
D
R
A
V
E
---------
A
---------
H
L
-----------
A
--------
T
R
G
S
E
R
L
A
-------
T
S
D
V
G
E
R
I
A
A
A
----------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
97.85
100%
-107
- C5 -
1W0D
1
LEU3_MYCTU
C:
[3-337]
-------------------
K
L
A
I
I
A
G
D
G
I
G
P
E
V
T
A
E
A
V
K
V
L
----
D
A
V
V
P
-------
G
----
V
Q
K
T
S
Y
D
----
L
-----
G
A
---
R
R
F
H
A
-
T
-
G
E
V
L
P
D
S
V
V
A
E
L
R
-
N
H
-
D
A
I
L
L
G
A
I
G
D
P
-
S
---
V
----
P
---
S
----
G
V
L
E
R
G
L
-----
L
L
R
L
R
F
E
L
D
H
H
I
N
L
R
P
A
R
L
Y
P
G
V
--
A
--
S
--
P
L
S
G
---
N
---
P
--
G
I
D
F
V
V
V
R
E
G
T
E
G
P
Y
T
G
N
G
G
A
I
R
V
G
T
-------------------
P
N
E
V
A
T
E
-----
V
S
V
N
T
A
F
----
G
V
R
R
V
V
A
D
A
F
E
R
A
R
R
R
------------
R
-
K
-------------
H
L
T
L
V
H
K
T
N
V
L
T
F
A
G
G
L
W
---
L
R
T
V
D
E
V
G
---
E
C
Y
P
D
--------------------------------
V
E
V
A
Y
Q
H
V
D
A
A
T
I
H
M
I
T
D
P
G
R
F
D
V
I
V
T
D
N
L
F
G
D
I
I
T
D
L
A
A
A
V
C
G
G
I
G
L
A
A
S
G
N
I
D
A
T
R
A
N
P
S
M
F
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
I
A
D
P
T
A
A
I
M
S
V
A
L
L
L
S
H
-
L
-
G
E
H
D
A
A
A
R
V
D
R
A
V
E
---------
A
---------
H
L
-----------
A
--------
T
R
G
S
E
R
L
A
-------
T
S
D
V
G
E
R
I
A
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.83
100%
-109
- C5 -
1W0D
-
LEU3_MYCTU
A:
[3-337]
-------------------
K
L
A
I
I
A
G
D
G
I
G
P
E
V
T
A
E
A
V
K
V
L
----
D
A
V
V
P
-------
G
----
V
Q
K
T
S
Y
D
----
L
-----
G
A
---
R
R
F
H
A
-
T
-
G
E
V
L
P
D
S
V
V
A
E
L
R
-
N
H
-
D
A
I
L
L
G
A
I
G
D
P
-
S
---
V
----
P
---
S
----
G
V
L
E
R
G
L
-----
L
L
R
L
R
F
E
L
D
H
H
I
N
L
R
P
A
R
L
Y
P
G
V
--
A
--
S
--
P
L
S
G
---
N
---
P
--
G
I
D
F
V
V
V
R
E
G
T
E
G
P
Y
T
G
N
G
G
A
I
R
V
G
T
-------------------
P
N
E
V
A
T
E
-----
V
S
V
N
T
A
F
----
G
V
R
R
V
V
A
D
A
F
E
R
A
R
R
R
------------
R
-
K
-------------
H
L
T
L
V
H
K
T
N
V
L
T
F
A
G
G
L
W
---
L
R
T
V
D
E
V
G
---
E
C
Y
P
D
--------------------------------
V
E
V
A
Y
Q
H
V
D
A
A
T
I
H
M
I
T
D
P
G
R
F
D
V
I
V
T
D
N
L
F
G
D
I
I
T
D
L
A
A
A
V
C
G
G
I
G
L
A
A
S
G
N
I
D
A
T
R
A
N
P
S
M
F
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
I
A
D
P
T
A
A
I
M
S
V
A
L
L
L
S
H
-
L
-
G
E
H
D
A
A
A
R
V
D
R
A
V
E
---------
A
---------
H
L
-----------
A
--------
T
R
G
S
E
R
L
A
-------
T
S
D
V
G
E
R
I
A
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
97.44
100%
-106
- C5 -
1W0D
1
LEU3_MYCTU
D:
[3-337]
-------------------
K
L
A
I
I
A
G
D
G
I
G
P
E
V
T
A
E
A
V
K
V
L
----
D
A
V
V
P
-------
G
----
V
Q
K
T
S
Y
D
----
L
-----
G
A
---
R
R
F
H
A
-
T
-
G
E
V
L
P
D
S
V
V
A
E
L
R
-
N
H
-
D
A
I
L
L
G
A
I
G
D
P
-
S
---
V
----
P
---
S
----
G
V
L
E
R
G
L
-----
L
L
R
L
R
F
E
L
D
H
H
I
N
L
R
P
A
R
L
Y
P
G
V
--
A
--
S
--
P
L
S
G
---
N
---
P
--
G
I
D
F
V
V
V
R
E
G
T
E
G
P
Y
T
G
N
G
G
A
I
R
V
G
T
-------------------
P
N
E
V
A
T
E
-----
V
S
V
N
T
A
F
----
G
V
R
R
V
V
A
D
A
F
E
R
A
R
R
R
------------
R
-
K
-------------
H
L
T
L
V
H
K
T
N
V
L
T
F
A
G
G
L
W
---
L
R
T
V
D
E
V
G
---
E
C
Y
P
D
--------------------------------
V
E
V
A
Y
Q
H
V
D
A
A
T
I
H
M
I
T
D
P
G
R
F
D
V
I
V
T
D
N
L
F
G
D
I
I
T
D
L
A
A
A
V
C
G
G
I
G
L
A
A
S
G
N
I
D
A
T
R
A
N
P
S
M
F
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
I
A
D
P
T
A
A
I
M
S
V
A
L
L
L
S
H
-
L
-
G
E
H
D
A
A
A
R
V
D
R
A
V
E
---------
A
---------
H
L
-----------
A
--------
T
R
G
S
E
R
L
A
-------
T
S
D
V
G
E
R
I
A
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
96.82
100%
-109
- C5 -
2G4O
1
LEU3_MYCTU
B:
[3-337]
-------------------
K
L
A
I
I
A
G
D
G
I
G
P
E
V
T
A
E
A
V
K
V
L
----
D
A
V
V
P
-------
G
----
V
Q
K
T
S
Y
D
----
L
-----
G
A
---
R
R
F
H
A
-
T
-
G
E
V
L
P
D
S
V
V
A
E
L
R
-
N
H
-
D
A
I
L
L
G
A
I
G
D
P
-
S
---
V
----
P
---
S
----
G
V
L
E
R
G
L
-----
L
L
R
L
R
F
E
L
D
H
H
I
N
L
R
P
A
R
L
Y
P
G
V
--
A
--
S
--
P
L
S
G
---
N
---
P
--
G
I
D
F
V
V
V
R
E
G
T
E
G
P
Y
T
G
N
G
G
A
I
R
V
G
T
-------------------
P
N
E
V
A
T
E
-----
V
S
V
N
T
A
F
----
G
V
R
R
V
V
A
D
A
F
E
R
A
R
R
R
------------
R
-
K
-------------
H
L
T
L
V
H
K
T
N
V
L
T
F
A
G
G
L
W
---
L
R
T
V
D
E
V
G
---
E
C
Y
P
D
--------------------------------
V
E
V
A
Y
Q
H
V
D
A
A
T
I
H
M
I
T
D
P
G
R
F
D
V
I
V
T
D
N
L
F
G
D
I
I
T
D
L
A
A
A
V
C
G
G
I
G
L
A
A
S
G
N
I
D
A
T
R
A
N
P
S
M
F
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
I
A
D
P
T
A
A
I
M
S
V
A
L
L
L
S
H
-
L
-
G
E
H
D
A
A
A
R
V
D
R
A
V
E
---------
A
---------
H
L
-----------
A
--------
T
R
G
S
E
R
L
A
-------
T
S
D
V
G
E
R
I
A
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
81.96
40%
-107
- C5 -
3VMK
5
?
A:
[15-371]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
A
A
V
E
K
R
F
D
L
---
S
----
I
E
Y
S
E
Y
D
----
V
-----
G
G
---
A
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
V
L
F
G
S
V
G
G
P
-
K
---
W
EHLP
P
---
N
----
D
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
E
K
--
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
N
E
E
A
F
D
-----
T
M
R
Y
S
R
K
----
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
E
V
V
E
E
V
A
---
K
D
Y
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
--
I
S
M
N
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
S
L
-
K
L
E
D
A
A
L
A
I
E
A
A
V
S
---------
K
---------
A
L
S
D
GYLTCELLP
A
--------
S
E
R
S
Q
A
K
S
-------
T
S
Q
M
G
D
Y
I
A
Q
A
I
---------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
78.95
38%
-102
- C5 -
1CNZ
8
LEU3_SALTY
B:
[7-356]
--------------------
I
A
V
L
P
G
D
G
I
G
P
E
V
M
A
Q
A
L
K
V
M
----
D
A
V
R
S
-------
R
FDMR
I
T
T
S
H
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
H
P
L
P
K
A
T
V
E
G
C
E
-
Q
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
ENLP
P
---
E
----
S
Q
P
E
R
G
A
-----
L
L
P
L
R
K
H
F
K
L
F
S
N
L
R
P
A
K
L
Y
Q
G
L
--
E
--
A
FC
P
L
R
A
---
D
IAA
N
--
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
Q
P
K
G
R
E
G
S
G
-------------------
Q
Y
E
K
A
F
D
-----
T
E
V
Y
H
R
F
----
E
I
E
R
I
A
R
I
A
F
E
S
A
R
K
R
------------
R
-
R
-------------
K
V
T
S
I
D
K
A
N
V
L
Q
-
S
S
I
L
W
---
R
E
I
V
N
D
V
A
---
K
T
Y
P
D
--------------------------------
V
E
L
A
H
M
Y
I
D
N
A
T
M
Q
L
I
K
D
P
S
Q
F
D
V
L
L
C
S
N
L
F
G
D
I
L
S
D
E
C
A
M
I
T
G
S
M
G
M
L
P
S
A
S
L
N
--
E
Q
G
F
G
L
Y
E
P
A
G
G
S
A
P
D
I
A
G
K
N
I
A
N
P
I
A
Q
I
L
S
L
A
L
L
L
R
Y
S
L
-
D
A
N
D
A
A
T
A
I
E
Q
A
I
N
---------
R
---------
A
L
-----------
E
EGVRTGDL
A
R
G
A
A
A
V
S
-------
T
D
E
M
G
D
I
I
A
------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
78.64
40%
-107
- C5 -
3VMK
5
?
B:
[15-371]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
A
A
V
E
K
R
F
D
L
---
S
----
I
E
Y
S
E
Y
D
----
V
-----
G
G
---
A
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
V
L
F
G
S
V
G
G
P
-
K
---
W
EHLP
P
---
N
----
D
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
E
K
--
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
N
E
E
A
F
D
-----
T
M
R
Y
S
R
K
----
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
E
V
V
E
E
V
A
---
K
D
Y
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
--
I
S
M
N
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
S
L
-
K
L
E
D
A
A
L
A
I
E
A
A
V
S
---------
K
---------
A
L
S
D
GYLTCELLP
A
--------
S
E
R
S
Q
A
K
S
-------
T
S
Q
M
G
D
Y
I
A
Q
A
I
---------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
77.52
40%
-100
- C5 -
1CNZ
6
LEU3_SALTY
A:
[5-342]
------------------
Y
H
I
A
V
L
P
G
D
G
I
G
P
E
V
M
A
Q
A
L
K
V
M
----
D
A
V
R
S
R
FD
M
---
R
----
I
T
T
S
H
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
H
P
L
P
K
A
T
V
E
G
C
E
-
Q
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
----
E
---
N
LPPE
S
Q
P
E
R
G
A
-----
L
L
P
L
R
K
H
F
K
L
F
S
N
L
R
P
A
K
L
Y
Q
G
L
--
E
AF
C
--
P
L
R
A
---
D
I
A
A
N
--
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
Q
P
K
G
R
E
G
S
G
-------------------
Q
Y
E
K
A
F
D
-----
T
E
V
Y
H
R
F
----
E
I
E
R
I
A
R
I
A
F
E
S
A
R
K
R
------------
R
-
R
-------------
K
V
T
S
I
D
K
A
N
V
L
Q
-
S
S
I
L
W
---
R
E
I
V
N
D
V
A
---
K
T
Y
P
D
--------------------------------
V
E
L
A
H
M
Y
I
D
N
A
T
M
Q
L
I
K
D
P
S
Q
F
D
V
L
L
C
S
N
L
F
G
D
I
L
S
D
E
C
A
M
I
T
G
S
M
G
M
L
P
S
A
S
L
N
E
Q
--
G
F
G
L
Y
E
P
A
G
G
S
A
P
D
I
A
G
K
N
I
A
N
P
I
A
Q
I
L
S
L
A
L
L
L
R
Y
S
L
-
D
A
N
D
A
A
T
A
I
E
Q
A
I
N
---------
R
---------
A
L
-----------
E
--------
E
G
----
V
R
-------
T
G
D
L
A
R
G
--------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
77.52
38%
-100
- C5 -
1CNZ
6
LEU3_SALTY
A:
[7-356]
--------------------
I
A
V
L
P
G
D
G
I
G
P
E
V
M
A
Q
A
L
K
V
M
----
D
A
V
R
S
-------
R
FD
M
R
I
T
T
S
H
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
H
P
L
P
K
A
T
V
E
G
C
E
-
Q
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
ENLP
P
---
E
----
S
Q
P
E
R
G
A
-----
L
L
P
L
R
K
H
F
K
L
F
S
N
L
R
P
A
K
L
Y
Q
G
L
--
E
--
A
FC
P
L
R
A
---
D
I
A
A
N
--
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
Q
P
K
G
R
E
G
S
G
-------------------
Q
Y
E
K
A
F
D
-----
T
E
V
Y
H
R
F
----
E
I
E
R
I
A
R
I
A
F
E
S
A
R
K
R
------------
R
-
R
-------------
K
V
T
S
I
D
K
A
N
V
L
Q
-
S
S
I
L
W
---
R
E
I
V
N
D
V
A
---
K
T
Y
P
D
--------------------------------
V
E
L
A
H
M
Y
I
D
N
A
T
M
Q
L
I
K
D
P
S
Q
F
D
V
L
L
C
S
N
L
F
G
D
I
L
S
D
E
C
A
M
I
T
G
S
M
G
M
L
P
S
A
S
L
N
--
E
Q
G
F
G
L
Y
E
P
A
G
G
S
A
P
D
I
A
G
K
N
I
A
N
P
I
A
Q
I
L
S
L
A
L
L
L
R
Y
S
L
-
D
A
N
D
A
A
T
A
I
E
Q
A
I
N
---------
R
---------
A
L
-----------
E
E
GVRTGDL
A
R
G
A
A
A
V
S
-------
T
D
E
M
G
D
I
I
A
------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
77.00
39%
-108
- C5 -
1A05
4
LEU3_ACIFR
A:
[3-354]
-------------------
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
----
D
A
V
D
Q
A
A
HL---
G
----
L
R
C
T
E
G
L
----
V
-----
G
G
---
A
A
L
D
A
-
S
-
D
D
P
L
P
A
A
S
L
Q
L
A
M
-
A
A
-
D
A
V
I
L
G
A
V
G
G
P
-
R
---
W
DAYP
P
---
A
----
K
R
P
E
Q
G
L
-----
L
-
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
LD
A
--
S
--
P
L
R
P
---
E
LV-
R
--
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
Q
P
R
G
L
E
V
I
D
-------------------
G
K
R
R
G
F
N
-----
T
M
V
Y
D
E
D
----
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
------------
R
-
K
-------------
Q
L
C
S
V
D
K
A
N
V
L
E
T
T
R
-
L
W
---
R
E
V
V
T
E
V
A
---
R
D
Y
P
D
--------------------------------
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
E
G
R
A
---
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
S
L
-
N
A
E
P
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
GLRT
A
---------
D
I
-----------
A
--------
A
P
G
T
P
V
I
G
-------
T
K
A
M
G
A
A
V
V
N
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
76.97
42%
-103
- C5 -
3VMK
5
?
A:
[14-351]
------------------
Y
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
A
A
V
E
K
R
F
D
L
---
S
----
I
E
Y
S
E
Y
D
----
V
-----
G
G
---
A
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
V
L
F
G
S
V
G
G
P
-
K
---
W
----
E
HLP
P
N---
D
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
--
E
HM
S
--
P
L
R
S
D
I
S
E
---
K
--
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
N
E
E
A
F
D
-----
T
M
R
Y
S
R
K
----
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
E
V
V
E
E
V
A
---
K
D
Y
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
S
Q
--
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
S
L
-
K
L
E
D
A
A
L
A
I
E
A
A
V
S
---------
K
---------
A
L
-----------
S
--------
D
G
----
Y
L
-------
T
C
E
L
L
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
76.91
38%
-106
- C5 -
4XXV
3
LEU3_BURTA
B:
[9-363]
------------------
M
K
I
A
V
L
P
G
D
G
I
G
P
E
I
V
N
E
A
V
K
V
L
----
N
A
L
D
E
-------
K
----
F
E
L
E
H
A
P
----
V
-----
G
G
---
A
G
Y
E
A
-
S
-
G
H
P
L
P
D
A
T
L
A
L
A
K
-
E
A
-
D
A
I
L
F
G
A
V
G
D
W
-
K
---
Y
----
D
---
S
------
L
E
R
A
L
RPE
Q
A
I
L
G
L
R
K
H
L
E
L
F
A
N
F
R
P
A
I
C
Y
P
Q
L
VD
A
--
S
--
P
L
K
P
---
E
LV-
A
--
G
L
D
I
L
I
V
R
E
L
N
G
D
I
Y
F
G
Q
P
R
G
V
R
A
A
P
-------------------
D
G
P
F
A
G
E
R
E
G
F
D
T
M
R
Y
S
E
P
----
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
R
------------
A
-
K
-------------
K
L
L
S
V
D
K
S
N
V
L
E
-
T
S
Q
F
W
---
R
D
V
M
I
D
V
S
---
K
E
Y
A
D
--------------------------------
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
K
Q
F
D
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
T
G
S
I
G
M
L
P
S
A
S
L
D
--
K
N
N
K
G
L
Y
E
P
S
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
L
L
R
Y
S
L
-
N
R
A
E
Q
A
D
R
I
E
R
A
V
K
---------
T
---------
V
L
E
Q
GYRTGDI--
A
--------
T
P
G
C
R
Q
V
G
-------
T
A
A
M
G
D
A
V
V
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
76.89
39%
-106
- C5 -
1A05
4
LEU3_ACIFR
B:
[3-354]
-------------------
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
----
D
A
V
D
Q
AAHL---
G
----
L
R
C
T
E
G
L
----
V
-----
G
G
---
A
A
L
D
A
-
S
-
D
D
P
L
P
A
A
S
L
Q
L
A
M
-
A
A
-
D
A
V
I
L
G
A
V
G
G
P
-
R
---
W
DAYP
P
---
A
----
K
R
P
E
Q
G
L
-----
L
-
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
LD
A
--
S
--
P
L
R
P
---
E
LV-
R
--
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
Q
P
R
G
L
E
V
I
D
-------------------
G
K
R
R
G
F
N
-----
T
M
V
Y
D
E
D
----
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
------------
R
-
K
-------------
Q
L
C
S
V
D
K
A
N
V
L
E
T
T
R
-
L
W
---
R
E
V
V
T
E
V
A
---
R
D
Y
P
D
--------------------------------
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
E
G
R
A
---
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
S
L
-
N
A
E
P
W
A
Q
R
V
E
A
A
V
Q
RVLDQGLRT
A
---------
D
I
-----------
A
--------
A
P
G
T
P
V
I
G
-------
T
K
A
M
G
A
A
V
V
N
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
76.87
41%
-110
- C5 -
3VML
3
LEU3_SHEON
A:
[15-341]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
K
A
V
E
A
R
F
G
L
---
N
----
I
E
Y
T
E
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
V
L
F
G
S
V
G
G
P
-
K
---
W
EHLP
P
---
N
----
D
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
E
K
--
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
N
E
E
A
F
D
-----
T
M
R
Y
S
R
K
----
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
E
V
V
E
E
V
A
---
K
D
Y
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
--
I
S
M
N
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
S
L
-
K
L
E
D
A
A
L
A
I
E
A
A
V
S
---------
K
---------
A
L
-----------
N
--------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
76.59
37%
-102
- C5 -
1VLC
1
LEU3_THEMA
A:
[13-362]
------------------
M
K
I
A
V
L
P
G
D
G
I
G
P
E
V
V
R
E
A
L
K
V
L
----
E
V
V
E
K
-------
K
----
T
G
K
T
F
E
K
V
F
G
H
I
-----
G
G
---
D
A
I
D
R
-
F
-
G
E
P
L
P
E
E
T
K
K
I
C
L
-
E
A
-
D
A
I
F
L
G
S
V
G
G
P
-
K
---
W
DDLP
P
---
E
----
K
R
P
E
I
G
G
-----
L
L
A
L
R
K
M
L
N
L
Y
A
N
I
R
P
I
K
V
Y
R
S
L
--
V
HV
S
--
P
L
K
E
---
K
VIG
S
--
G
V
D
L
V
T
V
R
E
L
S
Y
G
V
Y
Y
G
Q
P
R
----
G
L
-------------------
D
E
E
K
G
F
D
-----
T
M
I
Y
D
R
K
----
T
V
E
R
I
A
R
T
A
F
E
I
A
K
N
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
-
Y
S
S
M
L
W
---
R
K
V
V
N
E
V
A
---
R
E
Y
P
D
--------------------------------
V
E
L
T
H
I
Y
V
D
N
A
A
M
Q
L
I
L
K
P
S
Q
F
D
V
I
L
T
T
N
M
F
G
D
I
L
S
D
E
S
A
A
L
P
G
S
L
G
L
L
P
S
----
A
S
F
G
D
K
N
L
Y
E
P
A
G
G
S
A
P
D
I
A
G
K
N
I
A
N
P
I
A
Q
I
L
S
L
A
M
M
L
E
H
S
F
-
G
M
V
E
E
A
R
K
I
E
R
A
V
E
---------
L
V
I
E
E
GYRTR
D
I
-----------
A
--------
E
D
P
E
K
A
V
S
-------
T
S
Q
M
G
D
L
I
C
K
K
L
---------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
76.46
38%
-101
- C5 -
4IWH
2
LEU3_BURTA
A:
[9-363]
------------------
M
K
I
A
V
L
P
G
D
G
I
G
P
E
I
V
N
E
A
V
K
V
L
----
N
A
L
D
E
-------
K
----
F
E
L
E
H
A
P
----
V
-----
G
G
---
A
G
Y
E
A
-
S
-
G
H
P
L
P
D
A
T
L
A
L
A
K
-
E
A
-
D
A
I
L
F
G
A
V
G
D
W
-
K
---
Y
----
D
---
S
------
L
E
R
A
L
R
P
E
Q
A
I
L
G
L
R
K
H
L
E
L
F
A
N
F
R
P
A
I
C
Y
P
Q
L
VD
A
--
S
--
P
L
K
P
---
E
LV-
A
--
G
L
D
I
L
I
V
R
E
L
N
G
D
I
Y
F
G
Q
P
R
G
V
R
A
A
P
-------------------
D
G
P
F
A
G
E
R
E
G
F
D
T
M
R
Y
S
E
P
----
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
R
------------
A
-
K
-------------
K
L
L
S
V
D
K
S
N
V
L
E
-
T
S
Q
F
W
---
R
D
V
M
I
D
V
S
---
K
E
Y
A
D
--------------------------------
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
K
Q
F
D
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
T
G
S
I
G
M
L
P
S
A
S
L
D
--
K
N
N
K
G
L
Y
E
P
S
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
L
L
R
Y
S
L
-
N
R
A
E
Q
A
D
R
I
E
R
A
V
K
---------
T
---------
V
L
E
Q
GYRTGDI--
A
--------
T
P
G
C
R
Q
V
G
-------
T
A
A
M
G
D
A
V
V
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
76.45
40%
-106
- C5 -
3VKZ
3
LEU3_SHEON
A:
[15-341]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
K
A
V
E
A
R
F
G
L
---
N
----
I
E
Y
T
E
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
EKLP
P
---
N
----
E
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
S
E
E
A
F
D
-----
T
M
R
Y
S
R
R
----
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
--
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
-
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
---------
K
---------
A
L
-----------
N
--------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
76.21
40%
-105
- C5 -
3VL2
3
LEU3_SHEON
A:
[15-341]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
K
A
V
E
A
R
F
G
L
---
N
----
I
E
Y
T
E
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
EKLP
P
---
N
----
E
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
S
E
E
A
F
D
-----
T
M
R
Y
S
R
R
----
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
--
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
-
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
---------
K
---------
A
L
-----------
N
--------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
76.10
40%
-103
- C5 -
3VL3
3
LEU3_SHEON
A:
[15-341]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
K
A
V
E
A
R
F
G
L
---
N
----
I
E
Y
T
E
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
EKLP
P
---
N
----
E
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
S
E
E
A
F
D
-----
T
M
R
Y
S
R
R
----
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
--
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
-
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
---------
K
---------
A
L
-----------
N
--------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
76.04
40%
-105
- C5 -
3WZX
2
LEU3_SHEON
A:
[15-341]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
K
A
V
E
A
R
F
G
L
---
N
----
I
E
Y
T
E
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
EKLP
P
---
N
----
E
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
S
E
E
A
F
D
-----
T
M
R
Y
S
R
R
----
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
A
S
M
N
S
T
--
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
-
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
---------
K
---------
A
L
-----------
N
--------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
76.03
40%
-105
- C5 -
3WZV
2
?
A:
[15-341]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
K
A
V
E
A
R
F
G
L
---
N
----
I
E
Y
T
E
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
EKLP
P
---
N
----
E
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
S
E
E
A
F
D
-----
T
M
R
Y
S
R
R
----
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
--
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
-
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
---------
K
---------
A
L
-----------
N
--------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
75.94
40%
-104
- C5 -
3VL7
3
LEU3_SHEON
A:
[15-341]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
K
A
V
E
A
R
F
G
L
---
N
----
I
E
Y
T
E
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
EKLP
P
---
N
----
E
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
S
E
E
A
F
D
-----
T
M
R
Y
S
R
R
----
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
--
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
-
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
---------
K
---------
A
L
-----------
N
--------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
75.91
40%
-104
- C5 -
3VMJ
3
LEU3_SHEON
A:
[15-341]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
K
A
V
E
A
R
F
G
L
---
N
----
I
E
Y
T
E
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
EKLP
P
---
N
----
E
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
S
E
E
A
F
D
-----
T
M
R
Y
S
R
R
----
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
--
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
-
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
---------
K
---------
A
L
-----------
N
--------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
75.66
40%
-102
- C5 -
3VL4
3
LEU3_SHEON
A:
[15-341]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
K
A
V
E
A
R
F
G
L
---
N
----
I
E
Y
T
E
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
EKLP
P
---
N
----
E
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
S
E
E
A
F
D
-----
T
M
R
Y
S
R
R
----
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
--
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
-
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
---------
K
---------
A
L
-----------
N
--------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
75.20
40%
-103
- C5 -
3WZY
2
LEU3_SHEON
A:
[15-341]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
K
A
V
E
A
R
F
G
L
---
N
----
I
E
Y
T
E
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
EKLP
P
---
N
----
E
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
S
E
E
A
F
D
-----
T
M
R
Y
S
R
R
----
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
A
S
M
N
S
T
--
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
-
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
---------
K
---------
A
L
-----------
N
--------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
74.90
40%
-102
- C5 -
3WZW
2
LEU3_SHEON
A:
[15-341]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
K
A
V
E
A
R
F
G
L
---
N
----
I
E
Y
T
E
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
EKLP
P
---
N
----
E
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
S
E
E
A
F
D
-----
T
M
R
Y
S
R
R
----
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
--
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
-
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
---------
K
---------
A
L
-----------
N
--------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
74.69
40%
-102
- C5 -
3VL6
3
LEU3_SHEON
A:
[15-341]
-------------------
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
----
K
A
V
E
A
R
F
G
L
---
N
----
I
E
Y
T
E
Y
D
----
V
-----
G
G
---
I
A
I
D
N
-
H
-
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
A
-
D
A
I
L
F
G
S
V
G
G
P
-
K
---
W
EKLP
P
---
N
----
E
Q
P
E
R
G
A
-----
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
--
E
HM
S
--
P
L
R
S
---
D
I
S
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
G
R
Q
G
E
G
-------------------
E
S
E
E
A
F
D
-----
T
M
R
Y
S
R
R
----
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
------------
R
-
K
-------------
K
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
---
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
--------------------------------
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
--
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
-
K
Q
E
E
A
A
S
A
I
E
R
A
V
T
---------
K
---------
A
L
-----------
N
--------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
73.99
41%
-102
- C5 -
1A05
4
LEU3_ACIFR
A:
[2-336]
------------------
K
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
----
D
A
V
D
Q
A
A
HL---
G
----
L
R
C
T
E
G
L
----
V
-----
G
G
---
A
A
L
D
A
-
S
-
D
D
P
L
P
A
A
S
L
Q
L
A
M
-
A
A
-
D
A
V
I
L
G
A
V
G
G
P
-
R
---
W
----
D
---
A
YPP-
A
K
R
P
E
Q
G
-----
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
--
L
DA
S
--
P
L
R
P
---
E
LV-
R
--
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
Q
P
R
G
L
E
V
I
D
-------------------
G
K
R
R
G
F
N
-----
T
M
V
Y
D
E
D
----
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
------------
R
-
K
-------------
Q
L
C
S
V
D
K
A
N
V
L
E
-
T
T
R
L
W
---
R
E
V
V
T
E
V
A
---
R
D
Y
P
D
--------------------------------
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
E
G
---
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
-
S
L
N
A
E
P
W
A
Q
R
V
E
A
A
V
Q
---------
R
---------
V
L
-----------
D
--------
Q
G
----
L
R
-------
T
A
D
I
A
A
P
--------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
73.13
42%
-110
- C5 -
4WUO
9
LEU3_THET8
B:
[4-322]
------------------
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
----
R
A
L
D
E
A
E
GL---
G
----
L
A
Y
E
V
F
P
----
F
-----
G
G
---
A
A
I
D
A
-
F
-
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
A
-
E
A
V
L
L
G
S
V
G
G
P
-
K
WDG
L
----
P
---
R
----
K
I
R
P
E
T
G
-----
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
--
E
RL
S
--
P
L
K
E
---
E
IA-
R
--
G
V
D
V
L
I
V
R
E
L
T
--------
G
G
I
Y
F
G
E
-------------------
P
R
G
M
S
E
A
-----
E
A
W
N
T
E
R
YS
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
------------
R
-
K
-------------
H
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
---
R
K
T
V
E
E
V
G
---
R
G
Y
P
D
--------------------------------
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
--
R
G
T
P
-
V
F
A
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
-
G
L
V
E
L
A
R
K
V
E
D
A
V
A
---------
K
---------
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.54
42%
-108
- C5 -
2Y41
4
LEU3_THET8
A:
[4-322]
------------------
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
----
R
A
L
D
E
A
E
GL---
G
----
L
A
Y
E
V
F
P
----
F
-----
G
G
---
A
A
I
D
A
-
F
-
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
A
-
E
A
V
L
L
G
S
V
G
G
P
-
K
WDG
L
----
P
---
R
----
K
I
R
P
E
T
G
-----
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
--
E
RL
S
--
P
L
K
E
---
E
IA-
R
--
G
V
D
V
L
I
V
R
E
L
T
--------
G
G
I
Y
F
G
E
-------------------
P
R
G
M
S
E
A
-----
E
A
W
N
T
E
R
YS
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
------------
R
-
K
-------------
H
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
---
R
K
T
V
E
E
V
G
---
R
G
Y
P
D
--------------------------------
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
--
R
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
-
G
L
V
E
L
A
R
K
V
E
D
A
V
A
---------
K
---------
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
72.38
42%
-108
- C5 -
4WUO
16
LEU3_THET8
A:
[4-322]
------------------
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
----
R
A
L
D
E
A
E
GL---
G
----
L
A
Y
E
V
F
P
----
F
-----
G
G
---
A
A
I
D
A
-
F
-
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
A
-
E
A
V
L
L
G
S
V
G
G
P
-
K
WDG
L
----
P
---
R
----
K
I
R
P
E
T
G
-----
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
--
E
RL
S
--
P
L
K
E
---
E
IA-
R
--
G
V
D
V
L
I
V
R
E
L
T
--------
G
G
I
Y
F
G
E
-------------------
P
R
G
M
S
E
A
-----
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
------------
R
-
K
-------------
H
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
---
R
K
T
V
E
E
V
G
---
R
G
Y
P
D
--------------------------------
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
--
R
G
T
P
-
V
F
A
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
-
G
L
V
E
L
A
R
K
V
E
D
A
V
A
---------
K
---------
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
72.02
44%
-101
- C5 -
2Y3Z
7
LEU3_THET8
A:
[4-334]
------------------
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
----
R
A
L
D
E
A
E
GL---
G
----
L
A
Y
E
V
F
P
----
F
-----
G
G
---
A
A
I
D
A
-
F
-
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
A
-
E
A
V
L
L
G
S
V
G
G
P
-
K
---
W
----
D
---
G
LPR-
K
I
R
P
E
T
G
-----
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
--
E
RL
S
--
P
L
K
E
---
E
IA-
R
--
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
G
M
-----------------------
S
E
A
E
A
W
N
-----
T
E
R
Y
S
K
P
----
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
------------
R
-
K
-------------
H
V
V
S
V
D
K
A
N
V
L
E
V
-
G
E
F
W
---
R
K
T
V
E
E
V
G
---
R
G
Y
P
D
--------------------------------
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
G
---
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
-
G
L
V
E
L
A
R
K
V
E
D
A
V
A
---------
K
---------
A
L
-----------
L
--------
E
T
-----
P
-------
P
P
D
L
G
G
S
A
-------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.82
42%
-109
- C5 -
1HEX
1
LEU3_THET8
A:
[1-319]
------------------
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
----
R
A
L
D
E
A
E
GL---
G
----
L
A
Y
E
V
F
P
----
F
-----
G
G
---
A
A
I
D
A
-
F
-
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
A
-
E
A
V
L
L
G
S
V
G
G
P
-
K
WDG
L
----
P
---
R
----
K
I
R
P
E
T
G
-----
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
--
E
RL
S
--
P
L
K
E
---
E
IA-
R
--
G
V
D
V
L
I
V
R
E
L
T
--------
G
G
I
Y
F
G
E
-------------------
P
R
G
M
S
E
A
-----
E
A
W
N
T
E
R
YS
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
------------
R
-
K
-------------
H
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
---
R
K
T
V
E
E
V
G
---
R
G
Y
P
D
--------------------------------
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
--
R
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
-
G
L
V
E
L
A
R
K
V
E
D
A
V
A
---------
K
---------
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.61
42%
-104
- C5 -
2ZTW
3
LEU3_THET8
A:
[1-319]
------------------
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
----
R
A
L
D
E
A
E
GL---
G
----
L
A
Y
E
V
F
P
----
F
-----
G
G
---
A
A
I
D
A
-
F
-
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
A
-
E
A
V
L
L
G
S
V
G
G
P
-
K
WDG
L
----
P
---
R
----
K
I
R
P
E
T
G
-----
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
--
E
RL
S
--
P
L
K
E
---
E
IA-
R
--
G
V
D
V
L
I
V
R
E
L
T
--------
G
G
I
Y
F
G
E
-------------------
P
R
G
M
S
E
A
-----
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
------------
R
-
K
-------------
H
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
---
R
K
T
V
E
E
V
G
---
R
G
Y
P
D
--------------------------------
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
--
R
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
-
G
L
V
E
L
A
R
K
V
E
D
A
V
A
---------
K
---------
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
71.42
42%
-108
- C5 -
2Y41
4
LEU3_THET8
B:
[4-322]
------------------
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
----
R
A
L
D
E
AEGL---
G
----
L
A
Y
E
V
F
P
----
F
-----
G
G
---
A
A
I
D
A
-
F
-
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
A
-
E
A
V
L
L
G
S
V
G
G
P
-
K
WDG
L
----
P
---
R
----
K
I
R
P
E
T
G
-----
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
--
E
RL
S
--
P
L
K
E
---
E
IA-
R
--
G
V
D
V
L
I
V
R
E
L
T
--------
G
G
I
Y
F
G
E
-------------------
P
R
G
M
S
E
A
-----
E
A
W
N
T
E
R
YSKP
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
------------
R
-
K
-------------
H
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
---
R
K
T
V
E
E
V
G
---
R
G
Y
P
D
--------------------------------
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
--
R
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
-
G
L
V
E
L
A
R
K
V
E
D
A
V
A
---------
K
---------
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.31
42%
-107
- C5 -
2Y3Z
7
LEU3_THET8
A:
[4-322]
------------------
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
----
R
A
L
D
E
A
E
GL---
G
----
L
A
Y
E
V
F
P
----
F
-----
G
G
---
A
A
I
D
A
-
F
-
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
A
-
E
A
V
L
L
G
S
V
G
G
P
-
K
WDG
L
----
P
---
R
----
K
I
R
P
E
T
G
-----
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
--
E
RL
S
--
P
L
K
E
---
E
IA-
R
--
G
V
D
V
L
I
V
R
E
L
T
--------
G
G
I
Y
F
G
E
-------------------
P
R
G
M
S
E
A
-----
E
A
W
N
T
E
R
YS
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
------------
R
-
K
-------------
H
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
---
R
K
T
V
E
E
V
G
---
R
G
Y
P
D
--------------------------------
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
--
R
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
-
G
L
V
E
L
A
R
K
V
E
D
A
V
A
---------
K
---------
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Fugue
70.14
34%
-93
- C5 -
2D1C
4
IDH_THET8
A:
[2-496]
P
L
I
T
T
ETG
K
K
M
H
V
L
EDG
R
K
L
I
T
V
I
P
G
D
G
I
G
P
E
C
V
E
A
T
L
K
V
L
----
E
A
A
K
A
-------
P
----
L
A
Y
E
V
R
E
----
A
-----
G
A
---
S
V
F
R
R
G
I
-
A
S
G
V
P
Q
E
T
I
E
S
I
R
-
K
T
-
R
V
V
L
K
G
P
L
----
E
---
T
----
P
---
V
----
G
Y
G
E
K
S
A
-----
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
P
N
V
--
P
--
T
--
P
Y
A
G
-------
R
--
G
I
D
L
V
V
V
R
E
N
V
E
D
L
Y
A
G
----
I
E
H
M
Q
-------------------
T
P
S
V
A
Q
T
-----
L
K
L
I
S
W
K
----
G
S
E
K
I
V
R
F
A
F
E
L
A
R
A
E
G-----------
R
-
K
-------------
K
V
H
C
A
T
K
S
N
I
M
K
L
A
E
G
T
L
---
K
R
A
F
E
Q
V
A
---
Q
E
Y
P
D
--------------------------------
I
E
A
V
H
I
I
V
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
T
S
G
L
I
G
G
L
G
F
A
P
S
A
N
I
G
N
---
E
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
V
L
L
S
A
V
M
M
L
R
Y
-
L
-
E
E
F
A
T
A
D
L
I
E
N
A
L
L
---------
Y
---------
T
L
-----------
E
E
G------
R
V
L
T
G
D
V
V
GYDRGAK
T
T
E
Y
T
E
A
I
I
Q
N
L
GKTPRKTQVRG
Y
K
P
F
R
L
PQVDGAIAPIVPR
S
R
R
V
V
G
V
D
V
F
V
E
T
NLL
P
E
A
L
G
K
A
L
E
D
L
A
AGTPFRLK
M
I
S
N
RGTQVYPPTGGL
T
D
L
V
D
H
Y
R
C
R
F
L
Y
TGEGEAK
D
P
E
I
L
D
L
V
S
R
V
A
S
R
F
R
W
M
H
L
E
K
L
Q
E
F
DGEPG
F
T
K
A
QGED
3
PsiBlast_PDB
69.67
41%
-97
- C5 -
3FMX
2
TTUC_PSEPU
X:
[6-322]
------------------
F
R
I
A
A
I
P
G
D
G
I
G
L
E
V
L
P
E
G
I
R
V
L
----
E
A
A
A
L
KHGL---
A
----
L
E
F
D
T
F
E
----
W
-----
A
S
---
C
D
Y
Y
L
-
Q
H
G
K
M
M
P
D
D
W
A
E
Q
L
K
-
Q
Y
-
D
A
I
Y
F
G
A
V
G
W
P
D
K
---
V
----
P
---
D
----
H
I
S
L
W
G
S
-----
L
L
K
F
R
R
E
F
D
Q
Y
V
N
I
R
P
V
R
L
F
P
G
V
--
P
--
C
--
A
L
A
N
---
R
---
K
VG
D
I
D
F
V
V
V
R
E
N
T
E
G
E
Y
S
S
L
G
G
I
M
F
E
N
T
-------------------
E
N
E
I
V
I
Q
-----
E
S
I
F
T
R
R
----
G
V
D
R
I
L
K
Y
A
F
D
L
A
E
K
R
E-----------
R
-
K
-------------
H
V
T
S
A
T
K
S
N
G
M
A
I
S
M
P
Y
W
---
D
K
R
T
E
A
M
A
---
A
H
Y
P
H
--------------------------------
V
S
W
D
K
Q
H
I
D
I
L
C
A
R
F
V
L
Q
P
E
R
F
D
V
V
V
A
S
N
L
F
G
D
I
L
S
D
L
G
P
A
C
A
G
T
I
G
I
A
P
S
A
N
L
N
P
E
R
N
F
P
S
L
F
E
P
V
H
G
S
A
P
D
I
F
G
K
N
I
A
N
P
I
A
M
I
W
S
G
A
L
M
L
E
F
-
L
-
G
Q
G
D
--
E
R
Y
Q
R
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
68.28
35%
-96
- C5 -
2D1C
4
IDH_THET8
B:
[22-335]
--------------------
I
T
V
I
P
G
D
G
I
G
P
E
C
V
E
A
T
L
K
V
L
----
E
A
A
K
A
-------
P
----
L
A
Y
E
V
R
E
----
A
-----
G
A
SVF
R
R
G
I
A
-
S
-
G
--
V
P
Q
E
T
I
E
S
I
R
-
K
T
-
R
V
V
L
K
G
P
L
----
E
---
T
----
P
---
V
----
G
Y
G
E
K
S
A
-----
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
P
N
V
--
P
--
T
--
P
Y
A
G
---
R
------
G
I
D
L
V
V
V
R
E
N
V
E
D
L
Y
---
A
G
I
E
H
M
Q
T
-------------------
P
S
-
V
A
Q
T
-----
L
K
L
I
S
W
K
----
G
S
E
K
I
V
R
F
A
F
E
L
A
R
A
E
G-----------
R
-
K
-------------
K
V
H
C
A
T
K
S
N
I
M
K
L
A
E
G
T
L
---
K
R
A
F
E
Q
V
A
---
Q
E
Y
P
D
--------------------------------
I
E
A
V
H
I
I
V
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
T
S
G
L
I
G
G
L
G
F
A
P
S
A
N
I
G
N
E
V
A
---
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
V
L
L
S
A
V
M
M
L
R
Y
-
L
-
E
E
F
A
T
A
D
L
I
E
N
A
L
---------------------
L
-----------
Y
--------
T
L
E
E
G
R
V
L
-------
T
G
D
V
-----------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
67.48
34%
-96
- C5 -
3TY4
5
LYS12_SCHPO
A:
[11-350]
------------------
I
V
L
G
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
----
E
N
L
P
A
KH-----
K
L
K
--
F
D
F
I
D
L
D
----
A
-----
G
W
---
G
T
F
E
R
-
T
-
G
K
A
L
P
E
R
T
V
E
R
L
K
T
E
C
-
N
A
A
L
F
G
A
V
Q
S
P
-
T
---
H
----
K
---
V
-----
A
G
Y
S
S
P
-----
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
A
--
K
--
G
-------------
K
--
P
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
E
R
M
V
Q
N
T
P
-------------------
G
K
R
V
A
E
A
-----
I
R
R
I
S
E
E
----
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
GTYSIH
K
K
P
-------------
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
---
R
E
S
C
R
H
A
Q
S
LD
P
S
Y
A
S
--------------------------------
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
D
N
---
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
E
F
-
M
-
G
H
Q
D
A
A
A
D
I
Y
T
A
V
D
---------
K
---------
V
L
-----------
T
--------
E
G
K
---
V
L
-------
T
P
D
L
G
G
K
--------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
66.72
33%
-96
- C5 -
3TY4
5
LYS12_SCHPO
A:
[13-348]
--------------------
L
G
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
----
E
N
L
-
P
-------
A
----
K
H
K
L
K
F
D
----
F
I
D
L
D
A
G
W
---
G
T
F
E
R
-
T
-
G
K
A
L
P
E
R
T
V
E
R
L
K
-
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
-
T
---
H
----
K
---
V
----
A
G
Y
S
S
P
I
-----
V
A
-
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
A
----------
K
G
---
K
---
P
---
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
E
R
M
V
Q
N
T
P
-------------------
G
K
R
V
A
E
A
-----
I
R
R
I
S
E
E
----
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
------------
Q
-
K
I
R
E
S
GTYSIHK
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
L
D
---
P
S
Y
A
S
--------------------------------
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
D
---
N
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
E
F
-
M
-
G
H
Q
D
A
A
A
D
I
Y
T
A
V
D
---------
K
---------
V
L
--------------------
T
E
G
--
K
V
L
-------
T
P
D
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
66.56
34%
-90
- C5 -
2D1C
4
IDH_THET8
A:
[20-338]
------------------
K
L
I
T
V
I
P
G
D
G
I
G
P
E
C
V
E
A
T
L
K
V
L
----
E
A
A
K
A
-------
P
----
L
A
Y
E
V
R
E
----
A
-----
G
A
---
S
V
F
R
R
G
I
-
A
S
G
V
P
Q
E
T
I
E
S
I
R
-
K
T
-
R
V
V
L
K
G
P
L
E
T
P
-
V
---
G
----
Y
---
G
-------
E
K
S
A
-----
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
P
N
V
--
P
--
T
--
P
Y
A
G
-------
R
--
G
I
D
L
V
V
V
R
E
N
V
E
D
L
Y
A
G
I
E
H
M
Q
T
P
S
-----------------------
V
A
Q
T
-----
L
K
L
I
S
W
K
----
G
S
E
K
I
V
R
F
A
F
E
L
A
R
A
E
------------
G
R
K
-------------
K
V
H
C
A
T
K
S
N
I
M
K
L
A
E
G
T
L
---
K
R
A
F
E
Q
V
A
---
Q
E
Y
P
D
--------------------------------
I
E
A
V
H
I
I
V
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
T
S
G
L
I
G
G
L
G
F
A
P
S
A
N
I
G
N
E
---
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
V
L
L
S
A
V
M
M
L
R
Y
-
L
-
E
E
F
A
T
A
D
L
I
E
N
A
L
L
---------
Y
---------
T
L
-----------
E
--------
E
G
R
---
V
L
-------
T
G
D
V
V
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
66.37
35%
-95
- C5 -
2D1C
4
IDH_THET8
A:
[22-335]
--------------------
I
T
V
I
P
G
D
G
I
G
P
E
C
V
E
A
T
L
K
V
L
----
E
A
A
K
A
-------
P
----
L
A
Y
E
V
R
E
----
A
-----
G
A
S
V
F
R
R
G
I
A
-
S
-
G
--
V
P
Q
E
T
I
E
S
I
R
-
K
T
-
R
V
V
L
K
G
P
L
----
E
---
T
----
P
---
V
----
G
Y
G
E
K
S
A
-----
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
P
N
V
--
P
--
T
--
P
Y
A
G
---
R
------
G
I
D
L
V
V
V
R
E
N
V
E
D
L
Y
---
A
G
I
E
H
M
Q
T
-------------------
P
S
-
V
A
Q
T
-----
L
K
L
I
S
W
K
----
G
S
E
K
I
V
R
F
A
F
E
L
A
R
A
E
G-----------
R
-
K
-------------
K
V
H
C
A
T
K
S
N
I
M
K
L
A
E
G
T
L
---
K
R
A
F
E
Q
V
A
---
Q
E
Y
P
D
--------------------------------
I
E
A
V
H
I
I
V
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
T
S
G
L
I
G
G
L
G
F
A
P
S
A
N
I
G
N
E
V
A
---
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
V
L
L
S
A
V
M
M
L
R
Y
-
L
-
E
E
F
A
T
A
D
L
I
E
N
A
L
---------------------
L
-----------
Y
--------
T
L
E
E
G
R
V
L
-------
T
G
D
V
-----------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
66.26
33%
-95
- C5 -
3TY3
4
LYS12_SCHPO
A:
[13-348]
--------------------
L
G
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
----
E
N
L
-
P
-------
A
----
K
H
K
L
K
F
D
----
F
I
D
L
D
A
G
W
---
G
T
F
E
R
-
T
-
G
K
A
L
P
E
R
T
V
E
R
L
K
-
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
-
T
---
H
----
K
---
V
----
A
G
Y
S
S
P
I
-----
V
A
-
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
A
----------
K
G
---
K
---
P
---
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
E
R
M
V
Q
N
T
P
-------------------
G
K
R
V
A
E
A
-----
I
R
R
I
S
E
E
----
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
------------
Q
-
K
I
R
E
S
G
T
Y
S
IHK
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
L
D
---
P
S
Y
A
S
--------------------------------
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
D
---
N
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
E
F
-
M
-
G
H
Q
D
A
A
A
D
I
Y
T
A
V
D
---------
K
---------
V
L
--------------------
T
E
G
--
K
V
L
-------
T
P
D
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
66.02
34%
-92
- C5 -
1HQS
7
IDH_BACSU
A:
[20-402]
------------------
P
I
I
P
F
I
E
G
D
G
T
G
P
D
I
W
N
A
A
S
K
V
L
----
E
A
A
V
E
K
A
Y
K
GE
K
K
----
I
T
W
K
E
V
Y
----
A
-----
G
E
---
K
A
Y
N
K
-
T
-
G
E
W
L
P
A
E
T
L
D
V
I
R
-
E
Y
-
F
I
A
I
K
G
P
L
T
T
P
-
V
---
G
----
G
---
G
-------
I
R
S
L
-----
N
V
A
L
R
Q
E
L
D
L
F
V
C
L
R
P
V
R
Y
F
T
G
V
--
P
--
S
--
P
V
K
R
---
P
---
E
--
D
T
D
M
V
I
F
R
E
N
T
E
D
I
Y
A
G
I
E
Y
A
K
G
S
E
E
V
Q
K
L
I
S
F
L
Q
NELNVNKIRF
P
E
T
S
G
I
G
-----
I
K
P
V
S
E
E
----
G
T
S
R
L
V
R
A
A
I
D
Y
A
I
E
H
------------
G
R
K
-------------
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
---
K
N
W
G
Y
E
L
A
E
--
K
E
Y
G
D
KVF
T
W
A
Q
Y
D
R
I
A
E
EQ
G
K
D
A
A
N
K
A
Q
S
E
A
E
A
A
G
K
I
I
I
K
D
S
I
A
D
I
F
L
Q
Q
I
L
T
R
P
N
E
F
D
V
V
A
T
M
N
L
N
G
D
Y
I
S
D
A
L
A
A
Q
V
G
G
I
G
I
A
P
G
A
N
I
N
Y
E
T
-
G
H
A
I
F
E
A
T
H
G
T
A
P
K
Y
A
G
L
D
K
V
N
P
S
S
V
I
L
S
G
V
L
L
L
E
H
-
L
-
G
W
N
E
A
A
D
L
V
I
K
S
M
E
---------
K
---------
T
I
-----------
A
--------
S
K
----
V
V
-------
T
Y
D
F
A
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
65.57
33%
-99
- C5 -
3TY4
7
LYS12_SCHPO
B:
[13-348]
--------------------
L
G
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
----
E
N
L
-
P
-------
A
----
K
H
K
L
K
F
D
----
F
I
D
L
D
A
G
W
---
G
T
F
E
R
-
T
-
G
K
A
L
P
E
R
T
V
E
R
L
K
-
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
-
T
---
H
----
K
---
V
----
A
G
Y
S
S
P
I
-----
V
A
-
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
A
----------
K
G
---
K
---
P
---
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
E
R
M
V
Q
N
T
P
-------------------
G
K
R
V
A
E
A
-----
I
R
R
I
S
E
E
----
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
------------
Q
-
K
I
R
E
S
G
T
Y
S
IHK
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
L
D
---
P
S
Y
A
S
--------------------------------
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
D
---
N
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
E
F
-
M
-
G
H
Q
D
A
A
A
D
I
Y
T
A
V
D
---------
K
---------
V
L
--------------------
T
E
G
--
K
V
L
-------
T
P
D
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
65.51
33%
-96
- C5 -
3TY3
2
LYS12_SCHPO
B:
[13-348]
--------------------
L
G
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
----
E
N
L
-
P
-------
A
----
K
H
K
L
K
F
D
----
F
I
D
L
D
A
G
W
---
G
T
F
E
-----
K
A
L
P
E
R
T
V
E
R
L
K
-
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
-
T
---
H
----
K
---
V
----
A
G
Y
S
S
P
I
-----
V
A
-
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
A
----------
K
G
---
K
---
P
---
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
E
R
M
V
Q
N
T
P
-------------------
G
K
R
V
A
E
A
-----
I
R
R
I
S
E
E
----
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
------------
Q
-
K
I
R
E
S
G
T
Y
S
IHK
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
L
D
---
P
S
Y
A
S
--------------------------------
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
D
---
N
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
E
F
-
M
-
G
H
Q
D
A
A
A
D
I
Y
T
A
V
D
---------
K
---------
V
L
--------------------
T
E
G
--
K
V
L
-------
T
P
D
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
64.15
33%
-104
- C5 -
4Y1P
2
?
B:
[5-300]
--------------------
V
A
L
I
Q
G
D
G
I
G
P
E
V
V
S
K
S
K
T
I
L
A
R
L
N
E
K
F
S
L
-------
P
----
I
E
Y
I
E
V
E
----
A
-----
G
D
---
T
T
K
N
K
-
F
-
G
D
A
L
P
K
D
S
L
R
V
I
E
-
K
A
-
D
M
I
L
K
G
P
V
G
E
T
-
A
---
A
----
D
--------------
V
-----
V
V
K
L
R
L
M
Y
D
L
Y
A
N
L
R
P
A
K
S
L
P
G
L
--
E
--
N
--
K
F
G
D
-----------
V
D
I
L
V
V
R
E
N
T
E
D
L
Y
K
G
L
E
H
V
I
S
D
G
-----------------------
V
T
V
G
-----
I
K
V
I
T
R
A
----
A
S
T
R
I
A
Q
V
A
L
N
Q
A
L
R
R
------------
K
-
K
-------------
K
V
V
C
V
H
K
S
N
V
M
R
I
T
D
G
L
F
---
A
E
S
C
R
N
V
-----
L
K
G
K
--------------------------------
V
E
Y
S
E
M
Y
V
D
A
A
A
A
N
L
V
R
N
P
Q
A
F
D
V
I
V
T
E
N
T
Y
G
D
I
L
S
D
E
A
G
Q
I
A
G
S
L
G
I
S
P
S
A
N
I
G
D
R
K
---
S
L
F
E
P
V
H
G
A
A
F
D
I
A
G
K
N
I
A
N
P
T
A
F
L
L
S
V
G
M
M
L
D
R
-
M
-
Q
E
L
S
G
D
I
R
Y
N
N
A
A
K
---------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------