@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3056: (2016-05-16 )
MPTAAPRWILHVDLDQFLASVELLRHPELAGLPVIVGGNGDPTEPRKVVTCASYEARAYGVRAGMPLRTAARRCPEATFLPSNPAAYNAASEEVVALLRDLGYPVEVWGWDEAYLAVAPGTPDDPIEVAEEIRKVILSQTGLSCSIGISDNKQRAKIATGLAKPAGIYQLTDANWMAIMGDRTVEALWGVGPKTTKRLAKLGINTVYQLAHTDSGLLMSTFGPRTALWLLLAKGGGDTEVSAQAWVPRSRSHAVTFPRDLTCRSEMESAVTELAQRTLNEVVASSRTVTRVAVTVRTATFYTRTKIRKLQAPSTDPDVITAAARHVLDLFELDRPVRLLGVRLELA
Atome Classification :
(31 SA)
--------------------------------------------------------------.........10........20........30-----.........40........50........60........70......---..80.-------.-.......90........100.--......110.....---..120------.--------------------.----------------------.----------------------------------------------------..------------------------------------...130.......140........150.......160.......170....-.....-180-.......190....-...200-........210........220......-.-230-........240.......250----.........--260.......270.......280..----.--....290.....---------------..300--...---......--310---------.----....---...320......---.330------.--.-----......340..-..---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------MPTAA
P
R
W
I
L
H
V
D
L
D
Q
F
L
A
S
V
E
L
LRHPELA------G
L
P
V
I
VGGNGDPTEP
R
K
V
V
T
CASYE
A
R
A
Y
GVRAGM
P
L
R
T
A
A
R
RCPEA---TFL-P-------S-NPAAYNA
A
S
E
E
V
V
A
L
L
R
DLGY--
P
V
E
V
WGWD
E
A
Y
L
A
V---APGT-------P--------------------D----------------------
D
----------------------------------------------------
P
I
------------------------------------
E
V
A
E
E
I
R
K
V
I
L
SQT-GL
S
C
S
IGISDN
K
Q
R
A
K
I
ATGLAKPA
G
I
Y
Q
L--TDA
N
-
W
M
A
I
M-GD
R
-
T
V
E
A
L
WGVG
P
K
T
T
K
-
R
L
A
K
L
--
G
I
N
T
V
Y
Q
L
AH-TDS
G
L
L
M
STFGPR
T
A
L
W
-
L
-
L
-
L
-AKGGGDT
E
V
S
A
Q
AWVPRSR------SHAVTFPRD--L
T
C
R
S
E
M
E
S
A
V
T
E
L
A
Q
R
T
L
N
E
V
V
AS----S--R
T
V
T
R
V
A
V
T
V
R
T
---------------
A
T
F
----
Y
T
R
---
T
K
I
R
KL--QA----------P----STD
P
---
D
V
I
T
A
A
A
R
H
V
L
D
---
L
F
-E------L--D-----RP
V
R
L
L
G
V
R
L
E-LA---
103
HHSearch
91.99
73%
-119
- C5 -
4DEZ
-
?
A:
[2-239]
-------------------------------------------------------------------
T
K
W
V
L
H
V
D
L
D
Q
F
L
A
S
V
E
L
R
R
R
P
D
L
R
------
G
Q
P
V
I
V
G
G
S
------
R
K
V
V
T
C
A
S
Y
E
A
R
E
F
G
V
H
A
G
M
P
L
R
A
A
A
R
R
C
P
D
A
---
T
F
L
-
P
-------
S
-
D
P
A
A
Y
D
E
A
S
E
Q
V
M
G
L
L
R
D
L
G
H
--
P
L
E
V
W
G
W
D
E
A
Y
L
G
A
---
D
L
P
D
-------
E
--------------------
S
----------------------
D
----------------------------------------------------
P
V
------------------------------------
E
V
A
E
R
I
R
T
V
V
A
A
E
T
-
G
L
S
C
S
V
G
I
S
D
N
K
Q
R
A
K
V
A
T
G
F
A
K
P
A
G
I
Y
V
L
--
T
E
A
N
-
W
M
T
V
M
-
G
D
R
-
P
P
D
A
L
W
G
V
G
P
K
T
T
K
-
K
L
A
A
M
--
G
I
T
T
V
A
D
L
A
V
-
T
D
P
S
V
L
T
T
A
F
G
P
S
T
G
L
W
-
L
L
L
-
L
-
A
K
G
G
G
D
T
E
V
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.89
73%
-117
- C5 -
4DEZ
-
?
A:
[3-239]
--------------------------------------------------------------------
K
W
V
L
H
V
D
L
D
Q
F
L
A
S
V
E
L
R
R
R
P
D
L
R
------
G
Q
P
V
I
V
G
G
S
------
R
K
V
V
T
C
A
S
Y
E
A
R
E
F
G
V
H
A
G
M
P
L
R
A
A
A
R
R
C
P
D
A
---
T
F
L
-
P
-------
S
-
D
P
A
A
Y
D
E
A
S
E
Q
V
M
G
L
L
R
D
L
G
H
--
P
L
E
V
W
G
W
D
E
A
Y
L
G
A
---
D
L
P
D
-------
E
--------------------
S
----------------------
D
----------------------------------------------------
P
V
------------------------------------
E
V
A
E
R
I
R
T
V
V
A
A
E
T
-
G
L
S
C
S
V
G
I
S
D
N
K
Q
R
A
K
V
A
T
G
F
A
K
P
A
G
I
Y
V
L
--
T
E
A
N
-
W
M
T
V
M
-
G
D
R
-
P
P
D
A
L
W
G
V
G
P
K
T
T
K
-
K
L
A
A
M
--
G
I
T
T
V
A
D
L
A
V
-
T
D
P
S
V
L
T
T
A
F
G
P
S
T
G
L
W
L
L
-
L
-
L
-
A
K
G
G
G
D
T
E
V
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
86.67
28%
-116
- C5 -
4TQR
7
DPO4_SULSO
A:
[2-339]
---------------------------------------------------------------------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
RD-----
Y
--------------------
R
----------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
I
S
-
L
-
A
R
D
E
Y
N
E
P
I
R
T
-
R
-
V
R
K
S
I
------
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
----
I
----
P
K
A
I
H
V
V
A
V
T
---------------
E
D
L
----
D
I
V
---
S
R
G
R
T
F
--
P
H
----------
G
----
I
S
K
----
E
T
A
Y
S
E
S
V
K
L
L
Q
---
K
I
L
E
E
-----
D
--
E
-----
R
K
I
R
R
I
G
V
R
F
S
-
K
----
108
HHSearch
83.40
26%
-110
- C5 -
4F50
3
DPO4_SULAC (first)
A:
[2-340]
---------------------------------------------------------------------
I
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
L
N
P
Q
Y
K
------
G
K
P
L
V
V
C
V
Y
S
-----
S
G
A
V
A
T
A
N
Y
E
A
R
K
L
G
V
K
A
G
M
P
I
I
K
A
M
Q
I
A
P
S
A
---
I
Y
V
-
P
-------
M
-
R
K
P
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
--
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
---
T
N
K
V
EGN----
F
--------------------
E
----------------------
N
----------------------------------------------------
G
I
------------------------------------
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
-
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
P
N
G
L
G
V
I
--
R
P
T
E
-
V
Q
D
F
L
-
N
E
L
-
D
I
D
E
I
P
G
I
G
S
V
L
A
R
-
R
L
N
E
L
--
G
I
Q
K
L
R
D
I
L
S
-
K
N
Y
N
E
L
E
K
I
T
G
K
A
K
A
L
Y
-
L
L
K
-
L
-
A
Q
N
K
Y
S
E
P
V
E
N
K
--
S
K
I
P
H
------
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
--------
I
P
K
A
I
H
V
V
A
V
T
---------------
E
D
L
----
D
I
V
---
S
R
G
R
T
F
--
P
H
----------
G
----
I
S
K
----
E
T
A
Y
S
E
S
V
K
L
L
Q
---
K
I
L
E
E
-----
D
--
E
-----
R
K
I
R
R
I
G
V
R
F
S
-
K
----
126
Fugue
83.02
27%
-101
- C5 -
2W7O
5
POLK_HUMAN
A:
[15-501]
KEK
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
R
N
L
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
------
D
K
P
I
A
V
G
S
M
S
-------
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
---
I
I
V
-
P
-------
P
-
N
F
D
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
D
P
--
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
---
T
K
H
L
-------
E
--------------------
E
R
Q
NWPEDKRRYFIKQN
S
V
V
F
G
T
S
----------------------------------------------------
A
Q
------------------------------------
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
-
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
P
N
R
Q
A
-
V
M
D
F
I
-
K
D
L
-
P
I
R
K
V
S
G
I
G
K
V
T
E
K
-
M
L
K
A
L
--
G
I
I
T
C
T
E
L
Y
Q
-
Q
R
A
L
L
S
L
L
F
S
E
T
S
W
H
Y
F
-
L
-
H
-
I
-
S
L
G
L
G
S
T
H
L
T
R
D
G
--
E
R
K
S
------
M
S
V
E
R
T
F
S
E
--
I
N
K
A
E
E
Q
Y
S
L
C
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
----
R
--
L
K
G
R
T
V
T
I
K
L
K
N
---------------
V
N
F
----
E
V
K
---
T
R
A
S
T
V
--
S
S
----------
V
----
V
S
T
A
---
E
E
I
F
A
I
A
K
E
L
L
K
---
T
E
-
I
------
D
--
A
DFPHP
L
R
L
R
L
M
G
V
R
I
S
-
S
F
PNE
131
Fugue
82.75
27%
-98
- C5 -
2OH2
4
POLK_HUMAN
A:
[15-499]
KE
K
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
R
N
L
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
------
D
K
P
I
A
V
G
S
M
S
-------
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
---
I
I
V
-
P
-------
P
-
N
F
D
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
D
P
--
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
---
T
K
H
L
-------
E
--------------------
E
R
Q
N
WPEDKR
R
Y
F
I
KN
S
V
V
F
G
T-
S
----------------------------------------------------
A
Q
------------------------------------
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
-
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
P
N
R
Q
A
-
V
M
D
F
I
-
K
D
L
-
P
I
R
K
V
S
G
I
G
K
V
T
E
K
-
M
L
K
A
L
--
G
I
I
T
C
T
E
L
Y
Q
-
Q
R
A
L
L
S
L
L
F
S
E
T
S
W
H
Y
F
-
L
-
H
-
I
-
S
L
G
L
G
S
T
H
L
T
R
D
G
--
E
R
K
S
------
M
S
V
E
R
T
F
S
E
--
I
N
K
A
E
E
Q
Y
S
L
C
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
----
R
--
L
K
G
R
T
V
T
I
K
L
K
N
---------------
V
N
F
----
E
V
K
---
T
R
A
S
T
V
--
S
S
----------
V
----
V
S
T
A
---
E
E
I
F
A
I
A
K
E
L
L
K
---
T
E
-
I
D
A
D
FP-
H
--
P
-----
L
R
L
R
L
M
G
V
R
I
S
-
S
F
P--
132
Fugue
81.50
27%
-96
- C5 -
1T3N
2
POLI_HUMAN
A:
[1-388]
-------------------------------------------------------------------
S
R
V
I
V
H
V
D
L
D
C
F
Y
A
Q
V
E
M
I
S
N
P
E
L
K
------
D
K
P
L
G
V
Q
Q
K
Y
-------
L
V
V
T
C
N
Y
E
A
R
K
L
G
V
K
K
L
M
N
V
R
D
A
K
E
K
C
P
Q
L
---
V
L
V
N
G
-------
E
-
D
L
T
R
Y
R
E
M
S
Y
K
V
T
E
L
L
E
E
F
S
P
--
V
V
E
R
L
G
F
D
E
N
F
V
D
L
---
T
E
M
V
-------
E
--------------------
K
----------------------
R
----------------------------------------------------
L
Q
Q
LQSDELSA
V
T
V
S
G
HVYNN
Q
S
I
N
LLD
V
L
H
I
R
L
L
V
G
S
Q
I
A
A
E
M
R
E
A
M
Y
N
Q
L
-
G
L
T
G
C
A
G
V
A
S
N
K
L
L
A
K
L
V
S
G
V
F
K
P
N
Q
Q
T
V
L
--
L
P
E
S
-
C
Q
H
L
I
H
S
L
N
-
H
I
K
E
I
P
G
I
G
Y
K
T
A
K
-
C
L
E
A
L
--
G
I
N
S
V
R
D
L
Q
T
-
F
S
P
K
I
L
E
K
E
L
G
I
S
V
A
Q
R
-
I
-
Q
-
K
-
L
S
F
G
E
D
N
S
P
V
I
L
S
G
P
P
Q
S
F
------
S
E
E
D
S
F
K
K
C
--
S
S
-
E
V
E
A
K
N
K
I
E
E
L
L
A
S
L
L
N
R
V
C
Q
D
----
G
--
R
K
P
H
T
V
R
L
I
I
R
R
---------------
Y
S
S
----
E
K
H
---
Y
G
R
E
S
R
--
Q
C
P
I
P
S
HVIQKL
G
----
T
G
N
Y
---
D
V
M
T
P
M
V
D
I
L
M
K
---
L
F
-
R
N
M
VNVK
M
--
P
-----
F
H
L
T
L
L
S
V
C
F
C
N
L
K
---
104
HHSearch
80.87
29%
-98
- C5 -
4Q45
5
DPO4_ECOLI
F:
[2-339]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
------
D
I
P
I
A
I
G
G
S
R
E
-
R
--
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
---
T
L
L
-
P
-------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
--
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
---
T
D
S
V
HC-----
H
--------------------
G
----------------------
S
----------------------------------------------------
A
T
------------------------------------
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
-
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
--
T
P
A
E
-
V
P
A
F
L
-
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
--
G
L
R
T
C
G
D
V
Q
A
-
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
-
R
-
S
Q
G
I
D
E
R
D
V
N
S
E
-
R
L
R
K
S
V
------
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
----
K
PD
L
L
I
A
R
Q
G
V
K
L
K
F
---------------
D
D
F
----
Q
Q
T
---
T
--
Q
E
H
--
V
W
----------
P
----
R
L
N
K
---
A
D
L
I
A
T
A
R
K
T
W
D
---
E
R
-
R
------
G
--
G
-----
R
G
V
R
L
V
G
L
H
V
T
-
L
----
125
Fugue
80.09
26%
-103
- C5 -
1K1Q
-
DPO4_SULSF
A:
[1-344]
--------------------------------------------------------------------
M
I
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
L
N
P
Q
Y
K
------
G
K
P
L
V
V
S
V
Y
S
-----------
A
N
Y
E
A
R
K
L
G
V
K
A
G
M
P
I
I
K
A
M
Q
I
A
P
S
A
---
I
Y
V
-
P
-------
M
-
R
K
P
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
--
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
TNK
V
E
G
N
-------
F
--------------------
E
----------------------
N
----------------------------------------------------
G
I
------------------------------------
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
-
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
P
N
G
L
G
V
I
--
R
P
T
E
-
V
Q
D
F
L
-
N
E
L
-
D
I
D
E
I
P
G
I
G
S
V
L
A
R
-
R
L
N
E
L
--
G
I
Q
K
L
R
D
I
L
S
-
K
N
Y
N
E
L
E
K
I
T
G
K
A
K
A
L
Y
-
L
-
L
K
L
-
A
Q
N
K
Y
S
E
P
V
E
N
K
S
--
K
I
P
H
------
G
R
Y
L
T
L
P
Y
N
--
T
R
D
V
K
V
I
L
P
Y
L
K
K
A
I
N
E
A
Y
N
K
---
V
----
N
--
G
I
P
M
R
I
T
V
I
A
I
M
---------------
E
D
L
----
D
I
L
---
S
K
G
K
K
F
--
K
H
----------
G
----
I
S
I
D
---
N
A
Y
K
V
A
E
D
L
L
R
E
---
L
L
-
V
------
R
DK
R
-----
R
N
V
R
R
I
G
V
K
L
D
-
N
I
IIN
109
HHSearch
79.91
26%
-104
- C5 -
3OSN
6
POLI_HUMAN
A:
[25-412]
-----------------------------------------------------------------
A
S
S
R
V
I
V
H
V
D
L
D
C
F
Y
A
Q
V
E
M
I
S
N
P
E
L
K
------
D
K
P
L
G
V
Q
Q
-------
K
Y
L
V
V
T
C
N
Y
E
A
R
K
L
G
V
K
K
L
M
N
V
R
D
A
K
E
K
C
P
Q
L
---
V
L
V
-
N
-------
G
E
D
L
T
R
Y
R
E
M
S
Y
K
V
T
E
L
L
E
E
F
S
P
--
V
V
E
R
L
G
F
D
E
N
F
V
D
L
---
T
E
M
V
E
------
K
R
L
Q
Q
LQSDELSA
V
T
V
S
G
HVY
N
N
Q
S
I
N
LLD
V
L
H
I
R
L
L
-------
V
----------------------------------------------------
G
S
------------------------------------
Q
I
A
A
E
M
R
E
A
M
Y
N
Q
L
-
G
L
T
G
C
A
G
V
A
S
N
K
L
L
A
K
L
V
S
G
V
F
K
P
N
Q
Q
T
V
L
--
L
P
E
S
-
C
Q
H
L
I
-
H
S
L
N
H
I
K
E
I
P
G
I
G
Y
K
T
A
K
-
C
L
E
A
L
--
G
I
N
S
V
R
D
L
Q
T
-
F
S
P
K
I
L
E
K
E
L
G
I
S
V
A
Q
R
-
I
Q
K
-
L
-
S
F
G
E
D
N
S
P
V
I
L
S
-
G
P
P
Q
S
F
------
S
E
E
D
S
F
K
K
---
C
S
S
E
V
E
A
K
N
K
I
E
E
L
L
A
S
L
L
N
R
V
C
Q
D
----
G
--
R
K
P
H
T
V
R
L
I
I
R
R
---------------
Y
S
S
E
K
H
Y
G
R
E
---
S
R
Q
C
P
I
--
P
S
----------
H
VIQK---
Y
D
V
M
T
P
M
V
D
I
L
M
K
L
F
R
---
N
M
V
N
------
V
KM
P
-----
F
H
L
T
L
L
S
V
C
F
C
-
N
----
111
HHSearch
79.75
25%
-94
- C5 -
4ECQ
7
POLH_HUMAN
A:
[5-431]
---------------------------------------------------------------
A
T
G
Q
D
R
V
V
A
L
V
D
M
D
C
F
F
V
Q
V
E
Q
R
Q
N
P
H
L
R
------
N
K
P
C
A
V
V
Q
Y
K
S
W
K
--
G
G
G
I
I
A
V
S
Y
E
A
R
A
F
G
V
T
R
S
M
W
A
D
D
A
K
K
L
C
P
D
L
---
L
L
A
-
Q
V
R
ESRGK
A
-
N
L
T
K
Y
R
E
A
S
V
E
V
M
E
I
M
S
R
F
A
---
V
I
E
R
A
S
I
D
E
A
Y
V
D
L
---
T
S
A
V
Q
E
R
L
Q
K
L
Q
--------------------
G
----------------------
Q
P
I
S
ADLLPSTYIEGLPQGPTVQ
K
E
G
M
R
K
Q
G
L
F
Q
W
L
D
S
LQIDNLTS
P
D
L
Q
L
T
V
G
A
------------------------------------
V
I
V
E
E
M
R
A
A
I
E
R
E
T
-
G
F
Q
C
S
A
G
I
S
H
N
K
V
L
A
K
L
A
C
G
L
N
K
P
N
R
Q
T
L
V
--
S
H
G
S
-
V
P
Q
L
F
-
S
Q
M
-
P
I
R
K
I
R
S
L
G
G
K
L
G
A
S
V
I
E
I
L
--
G
I
E
Y
M
G
E
L
T
Q
-
F
T
E
S
Q
L
Q
S
H
F
G
E
K
N
G
S
W
-
L
Y
A
-
M
-
C
R
G
I
E
H
D
P
V
K
P
R
-
Q
L
P
K
T
I
------
G
C
S
K
N
F
P
G
K
TA
L
A
T
R
E
Q
V
Q
W
W
L
L
Q
L
A
Q
E
L
E
E
R
L
T
K
D
R
N
D
N
D
--
R
V
A
T
Q
L
V
V
S
I
R
V
---------------
Q
G
D
----
K
R
L
SS
L
R
R
C
C
A
L
TR
Y
D
----------
A
----
H
K
M
S
---
H
D
A
F
T
V
I
K
N
C
N
T
SGI
Q
T
-
E
------
W
--
S
-----
P
P
L
T
M
L
F
L
C
A
T
-
K
----
128
Fugue
77.17
20%
-101
- C5 -
2AQ4
5
REV1_YEAST
A:
[1-434]
-----------------KRIVACDDPD
F
L
T
S
Y
F
A
H
S
R
L
H
H
L
S
A
W
K
A
N
L
K
D
K
F
L
N
E
N
I
HKY
T
K
I
T
D
K
D
T
Y
I
I
F
H
I
D
F
D
C
F
F
A
T
V
A
Y
L
C
R
S
S
S
F
SACDFK
R
D
P
I
V
V
C
H
G
T
----
K
N
S
D
I
A
S
C
N
Y
V
A
R
S
Y
G
I
K
N
G
M
W
V
S
Q
A
E
K
M
L
P
N
G
I
K
L
I
S
L
-
P
-------
Y
-
T
F
E
Q
F
Q
L
K
S
E
A
F
Y
S
T
L
K
R
L
N
I
FN
L
I
L
P
I
S
I
D
E
A
V
C
V
R
---
I
I
-
P
-------
D
--------------------
T
----------------------
L
----------------------------------------------------
N
A
------------------------------------
R
L
C
E
E
I
R
Q
E
I
F
Q
G
T
N
G
C
T
V
S
I
G
C
S
D
S
L
V
L
A
R
L
A
L
K
M
A
K
P
N
G
Y
N
I
T
--
F
K
S
N
L
S
E
E
F
W
-
S
S
F
-
K
L
D
D
L
P
G
V
G
H
S
T
L
S
-
R
L
E
S
T
F
D
S
P
H
S
L
N
D
L
R
K
R
Y
T
L
D
A
L
K
A
S
V
G
S
K
L
G
M
K
-
I
-
H
-
L
A
L
Q
G
Q
D
D
E
E
S
L
K
I
L
Y
D
P
K
E
V
L
QRK
S
L
S
I
D
I
N
W
G
I
R
--
F
K
N
I
T
Q
V
D
L
F
I
E
R
G
C
Q
Y
L
L
E
K
L
N
E
I
----
N
--
K
T
T
S
Q
I
T
L
K
L
M
R
RCKDAPIEPPKYMGM
G
R
C
----
D
S
F
---
S
R
S
S
R
L
--
G
I
----------
P
----
T
N
E
F
---
G
I
I
A
T
E
M
K
S
L
Y
R
---
T
L
-
G
------
C
P-
P
-----
M
E
L
R
G
L
A
L
Q
F
N
-
K
L
V
D
V
89
PsiBlast_CBE
76.84
33%
-117
- C5 -
2UVW
6
DPO4_SULSO
A:
[9-232]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
76.60
33%
-115
- C5 -
2IBK
7
DPO4_SULSO
A:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
76.29
33%
-115
- C5 -
2C28
6
DPO4_SULSO
A:
[9-232]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
76.29
33%
-118
- C5 -
2IA6
8
DPO4_SULSO
B:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
YR--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
76.27
33%
-113
- C5 -
2BR0
6
DPO4_SULSO
A:
[9-232]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
76.19
33%
-114
- C5 -
2BQU
6
DPO4_SULSO
A:
[9-232]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
76.07
33%
-116
- C5 -
2BQR
6
DPO4_SULSO
A:
[9-232]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
76.04
33%
-114
- C5 -
1S97
4
DPO4_SULSO
A:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
75.77
33%
-117
- C5 -
2RDJ
6
DPO4_SULSO
A:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.66
33%
-115
- C5 -
4QWB
12
DPO4_SULSO
A:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
75.37
33%
-113
- C5 -
3FDS
16
DPO4_SULSO
A:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.24
33%
-120
- C5 -
4TQR
7
DPO4_SULSO
A:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.22
33%
-118
- C5 -
4QWE
6
DPO4_SULSO
A:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
74.99
33%
-117
- C5 -
1RYS
5
DPO4_SULSO
A:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.68
33%
-115
- C5 -
4QWC
7
DPO4_SULSO
A:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
74.63
33%
-114
- C5 -
1S0M
6
DPO4_SULSO
A:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.63
33%
-111
- C5 -
4QWA
6
DPO4_SULSO
A:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
74.54
33%
-111
- C5 -
4GC6
6
DPO4_SULSO
A:
[9-232]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.52
33%
-114
- C5 -
1RYR
5
DPO4_SULSO
A:
[3-226]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
------
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
---
V
Y
L
-
P
-------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
---
S
D
K
V
-------
R
--------------------
D
Y
R
--------------------
E
----------------------------------------------------
A
Y
------------------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
--
D
D
E
E
-
V
K
R
L
I
-
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------