@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3121: (2016-05-17 )
MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT
Atome Classification :
(20 SA)
.........10.....-.-..20........30.......-.40-.-.......50.......--------------.60..--..--....70.-------.-..--.-...80----.---....-----..-.90-.........100.......110.......120...-...-.130--........140.......-150---.......160.......170-.....-....180.....---...190.......200.......210.-.....--.220.......230.......240.......250.----......260.-......270.......280.-..-.-..-..290......-.300.......310.......320........330-........340.......350.......360.......-370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTSTSIPTFPFDRPVP-T-EP
S
P
M
L
S
E
L
R
NSCPVA
P
I
ELP-SG
H
-
T
-
A
W
L
V
T
R
F
D
D
V
K
G
V
L
SD--------------K
R
F
S
C
--
R
A--AAHPSSP-------P-F
V
--
P
-
F
V
Q
L
C
----
P
---
S
L
LS-----ID-GP--
Q
H
T
A
A
R
R
L
L
A
QGLN
P
G
F
I
A
R
M
R
P
V
V
Q
Q
I
V
D
N
A
L
D
D
-
L
AA-AEP---PV
D
F
Q
E
I
VSVPI
G
E
Q
L
M
A
-
K
L
L---GVE
P
K
T
V
H
E
L
A
A
H
V
D
A
A
M
---
S
V
C
EI-
G
D
E
E
V
S
-
R
R
W
S
A
---
L
C
T
M
V
I
D
I
L
H
R
K
LAEP
G
D
D
L
L
S
T
I
A
Q
A-NRQQS--TM
T
D
E
Q
V
V
G
M
L
L
T
V
V
IGGVD
T
P
I
A
V
I
T
N
G
L
A
S
L
L
H
----
H
R
D
Q
Y
E
R
L
V
E-D
P
G
R
V
A
R
A
V
E
E
I
V
RFNP-AT-E
I
-
E
-
H
L
-
R
V
V
TE
D
V
V
I
A
G-TALSAGSPA
F
T
S
ITSANRDSDQF-LDPDEFDVER--NPNE
H
I
A
FGYGPHAC
P
A
S
A
Y
S
R
M
C
L
T
T
F
F
T
S
L
T
Q
RF
P
Q
-
L
QLAR
P
F
E
D
L
E
R
RGKG
L
H
S
V
G
I
K
E
L
L
VTWPT--
24
PsiBlast_CBE
94.99
33%
-113
- C7 -
4MM0
1
?
B:
[13-399]
--------
Y
P
F
D
R
A
V
P
-
T
-
A
I
P
P
L
Y
E
E
L
R
E
T
E
R
V
A
A
I
T
M
A
-
T
G
D
-
P
-
G
F
L
V
T
R
Y
E
D
V
R
F
V
L
S
D
--------------
P
R
F
S
V
--
R
Q
--
D
L
-
P
G
A
P
-------
R
-
L
T
--
E
-
M
T
--
F
----
E
---
S
V
M
T
-----
T
D
-
P
P
--
V
H
T
R
L
R
R
L
L
S
R
D
F
T
A
R
R
I
E
R
M
R
P
R
L
E
E
I
A
E
G
L
L
D
E
-
M
E
K
-
K
G
A
---
P
A
D
I
V
E
S
L
A
V
P
F
P
I
T
V
I
C
-
E
L
L
---
G
V
P
M
V
D
V
A
R
F
R
G
W
A
D
T
M
V
---
S
L
T
G
Y
-
S
M
E
D
W
T
-
A
A
R
D
A
---
L
E
S
Y
L
D
G
L
V
A
A
K
R
E
N
P
G
S
D
L
L
S
A
L
V
A
T
-
A
A
E
D
N
--
E
L
T
D
H
D
V
R
S
L
S
L
I
L
L
L
A
G
Y
E
P
A
S
N
Q
L
G
S
S
V
L
T
L
L
R
----
F
P
D
R
L
A
E
L
R
R
-
D
P
G
L
L
P
S
A
V
E
E
L
M
R
Y
A
P
-
A
G
-
D
G
-
A
-
L
F
-
R
V
T
L
E
D
V
T
I
G
D
-
T
H
I
P
A
N
S
A
V
L
A
S
T
Q
A
A
N
W
D
P
R
R
F
-
D
D
P
T
G
L
R
L
D
R
--
P
D
N
Q
H
T
A
L
G
H
G
I
H
F
C
L
G
A
A
L
A
R
V
E
L
Q
V
A
I
G
A
L
L
R
R
F
P
R
-
L
A
L
A
T
D
E
S
G
L
R
W
S
S
P
G
S
M
L
S
G
F
A
E
I
P
V
T
W
----
4
PsiBlast_PDB
94.52
33%
-113
- C7 -
4MM0
1
?
A:
[13-399]
--------
Y
P
F
D
R
A
V
P
-
T
-
A
I
P
P
L
Y
E
E
L
R
E
T
E
R
V
A
A
I
T
M
A
-
T
G
D
-
P
-
G
F
L
V
T
R
Y
E
D
V
R
F
V
L
S
D
--------------
P
R
F
S
V
--
R
Q
--
D
L
-
P
G
A
P
-------
R
-
L
T
--
E
-
M
T
--
F
----
E
---
S
V
M
T
-----
T
D
-
P
P
--
V
H
T
R
L
R
R
L
L
S
R
D
F
T
A
R
R
I
E
R
M
R
P
R
L
E
E
I
A
E
G
L
L
D
E
-
M
E
K
-
K
G
A
---
P
A
D
I
V
E
S
L
A
V
P
F
P
I
T
V
I
C
-
E
L
L
---
G
V
P
M
V
D
V
A
R
F
R
G
W
A
D
T
M
V
---
S
L
T
G
Y
-
S
M
E
D
W
T
-
A
A
R
D
A
---
L
E
S
Y
L
D
G
L
V
A
A
K
R
E
N
P
G
S
D
L
L
S
A
L
V
A
T
-
A
A
E
D
N
--
E
L
T
D
H
D
V
R
S
L
S
L
I
L
L
L
A
G
Y
E
P
A
S
N
Q
L
G
S
S
V
L
T
L
L
R
----
F
P
D
R
L
A
E
L
R
R
-
D
P
G
L
L
P
S
A
V
E
E
L
M
R
Y
A
P
-
A
G
-
D
G
-
A
-
L
F
-
R
V
T
L
E
D
V
T
I
G
D
-
T
H
I
P
A
N
S
A
V
L
A
S
T
Q
A
A
N
W
D
P
R
R
F
-
D
D
P
T
G
L
R
L
D
R
--
P
D
N
Q
H
T
A
L
G
H
G
I
H
F
C
L
G
A
A
L
A
R
V
E
L
Q
V
A
I
G
A
L
L
R
R
F
P
R
-
L
A
L
A
T
D
E
S
G
L
R
W
S
S
P
G
S
M
L
S
G
F
A
E
I
P
V
T
W
----
21
PsiBlast_CBE
94.41
34%
-109
- C7 -
4XE3
8
?
B:
[14-407]
-----
V
P
A
Y
P
F
S
L
P
H
A
-
L
-
D
L
D
P
H
Y
A
E
L
R
R
D
E
P
V
S
R
V
R
L
P
-
Y
G
E
G
T
-
A
W
L
V
T
R
M
S
D
A
R
I
V
L
G
D
--------------
S
R
F
S
T
--
A
A
--
A
T
D
P
A
T
P
-------
R
-
M
F
--
P
-
T
P
P
E
P
----
D
---
G
V
L
A
-----
Q
D
-
P
P
--
D
H
T
R
L
R
R
L
V
G
K
A
F
T
A
R
R
V
E
E
M
R
P
R
V
R
S
L
V
D
S
L
L
D
D
-
M
V
A
-
H
G
S
---
P
A
D
L
V
E
F
L
A
V
P
F
P
V
A
V
I
C
-
E
L
L
---
G
V
P
L
E
D
R
D
L
F
R
T
F
S
D
A
M
L
---
S
S
T
R
L
-
T
A
A
E
I
Q
-
R
V
Q
Q
D
---
F
M
V
Y
M
D
G
L
V
A
Q
R
R
D
A
P
T
E
D
L
L
G
A
L
A
L
A
-
T
D
N
D
D
--
H
L
T
K
G
E
I
V
N
M
G
V
S
L
L
I
A
G
H
E
T
S
V
N
Q
I
T
N
L
V
H
L
L
L
T
----
E
R
K
R
Y
E
S
L
V
A
-
D
P
A
L
V
P
A
A
V
E
E
M
L
R
Y
T
P
-
L
V
-
S
A
G
S
-
F
V
-
R
V
A
T
E
D
V
E
L
S
T
-
V
T
V
R
A
G
E
P
C
V
V
H
F
A
S
A
N
R
D
E
E
V
F
-
D
H
A
D
E
L
D
F
H
R
--
E
R
N
P
H
I
A
F
G
H
G
A
H
H
C
I
G
A
Q
L
G
R
L
E
L
Q
E
A
L
S
A
L
V
R
R
F
P
T
-
L
D
L
A
E
P
V
A
G
L
K
W
K
-
Q
G
M
L
I
R
G
L
E
R
Q
I
V
S
W
----
23
PsiBlast_CBE
94.22
31%
-108
- C7 -
4Z5P
2
?
B:
[8-400]
-----
V
H
I
Y
P
F
E
G
E
V
D
-
G
L
E
I
H
P
K
F
A
E
L
R
E
T
D
P
L
A
R
V
R
L
P
-
Y
G
G
-
E
-
G
W
M
V
T
R
Y
D
D
V
R
A
A
N
S
D
--------------
P
R
F
S
---
R
A
--
Q
I
G
E
D
T
P
-------
R
-
T
T
--
P
----------
D
---
T
I
L
S
-----
L
D
-
P
P
--
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
L
F
A
G
L
L
D
G
-
V
E
R
-
T
G
H
---
P
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
-
R
L
L
---
G
V
P
Y
E
D
R
G
R
F
Q
H
W
S
E
V
I
M
---
S
T
T
A
Y
-
S
K
E
E
A
V
-
S
A
D
A
S
---
I
R
A
Y
L
A
D
L
V
S
A
R
R
A
A
P
H
D
D
L
L
G
V
L
V
S
A
-
R
D
D
D
D
--
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
Y
A
L
L
T
----
H
E
D
Q
L
S
L
L
R
E
-
Q
P
E
L
L
P
R
A
V
E
E
L
L
R
F
V
P
L
G
N
-
G
V
-
G
-
N
A
-
R
I
A
L
E
D
V
E
L
S
G
-
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
-
D
D
P
D
R
L
D
I
T
R
--
E
K
N
P
H
L
A
F
G
H
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
-
L
R
L
A
V
P
A
D
Q
V
E
W
K
T
G
G
L
F
R
-
G
P
Q
R
L
P
I
A
W
----
3
PsiBlast_PDB
94.21
31%
-109
- C7 -
4Z5P
1
?
A:
[8-400]
-----
V
H
I
Y
P
F
E
G
E
V
D
-
G
L
E
I
H
P
K
F
A
E
L
R
E
T
D
P
L
A
R
V
R
L
P
-
Y
G
G
-
E
-
G
W
M
V
T
R
Y
D
D
V
R
A
A
N
S
D
--------------
P
R
F
S
---
R
A
--
Q
I
G
E
D
T
P
-------
R
-
T
T
--
P
----------
D
---
T
I
L
S
-----
L
D
-
P
P
--
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
L
F
A
G
L
L
D
G
-
V
E
R
-
T
G
H
---
P
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
-
R
L
L
---
G
V
P
Y
E
D
R
G
R
F
Q
H
W
S
E
V
I
M
---
S
T
T
A
Y
-
S
K
E
E
A
V
-
S
A
D
A
S
---
I
R
A
Y
L
A
D
L
V
S
A
R
R
A
A
P
H
D
D
L
L
G
V
L
V
S
A
-
R
D
D
D
D
--
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
Y
A
L
L
T
----
H
E
D
Q
L
S
L
L
R
E
-
Q
P
E
L
L
P
R
A
V
E
E
L
L
R
F
V
P
L
G
N
-
G
V
-
G
-
N
A
-
R
I
A
L
E
D
V
E
L
S
G
-
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
-
D
D
P
D
R
L
D
I
T
R
--
E
K
N
P
H
L
A
F
G
H
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
-
L
R
L
A
V
P
A
D
Q
V
E
W
K
T
G
G
L
F
R
-
G
P
Q
R
L
P
I
A
W
----
48
HHSearch
93.98
31%
-111
- C7 -
4Z5P
1
?
A:
[8-400]
-----
V
H
I
Y
P
F
E
G
E
V
D
G
L
-
E
I
H
P
K
F
A
E
L
R
E
T
D
P
L
A
R
V
R
L
P
-
Y
G
G
-
E
-
G
W
M
V
T
R
Y
D
D
V
R
A
A
N
S
D
--------------
P
R
F
S
R
--
A
Q
--
I
-
G
E
D
T
P
-------
R
-
T
T
--
P
----------
D
---
T
I
L
S
-----
L
D
-
P
P
--
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
L
F
A
G
L
L
D
G
-
V
E
R
-
T
G
H
---
P
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
-
R
L
L
---
G
V
P
Y
E
D
R
G
R
F
Q
H
W
S
E
V
I
M
---
S
T
-
T
A
Y
S
K
E
E
A
V
-
S
A
D
A
S
---
I
R
A
Y
L
A
D
L
V
S
A
R
R
A
A
P
H
D
D
L
L
G
V
L
V
S
A
-
R
D
D
D
D
--
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
Y
A
L
L
T
----
H
E
D
Q
L
S
L
L
R
E
-
Q
P
E
L
L
P
R
A
V
E
E
L
L
R
F
V
P
-
L
G
-
N
G
V
G
-
N
A
-
R
I
A
L
E
D
V
E
L
S
G
-
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
-
D
D
P
D
R
L
D
I
T
R
--
E
K
N
P
H
L
A
F
G
H
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
-
L
R
L
A
V
P
A
D
Q
V
E
W
K
T
-
G
G
L
F
R
G
P
Q
R
L
P
I
A
W
----
22
PsiBlast_CBE
93.98
34%
-102
- C7 -
2Z36
2
?
B:
[14-407]
--------
L
P
V
E
R
G
C
P
-
F
-
A
P
P
A
A
Y
E
R
L
R
E
R
A
P
I
N
K
V
R
L
T
-
S
G
G
-
Q
-
A
W
W
V
S
G
H
E
E
A
R
A
V
L
A
D
--------------
G
R
F
S
S
DK
R
K
--
D
G
F
P
L
F
T
-------
L
-
D
A
--
A
-
T
L
Q
Q
L
R
S
Q
P
P
---
L
M
L
G
-----
M
D
-
G
A
--
E
H
S
A
A
R
R
P
V
I
G
E
F
T
V
K
R
L
A
A
L
R
P
R
I
Q
D
I
V
D
H
F
I
D
D
M
L
A
T
-
D
Q
R
---
P
V
D
L
V
Q
A
L
S
L
P
V
P
S
L
V
I
C
-
E
L
L
---
G
V
-
P
Y
T
D
H
D
F
F
-
Q
S
R
T
T
M
---
M
V
S
R
T
-
S
M
E
D
R
R
-
R
A
F
A
E
---
L
R
A
Y
I
D
D
L
I
T
R
K
E
S
E
P
G
D
D
L
F
S
R
Q
I
A
R
-
Q
R
Q
E
G
--
T
L
D
H
A
G
L
V
S
L
A
F
L
L
L
T
A
G
H
E
T
T
A
N
M
I
S
L
G
V
V
G
L
L
S
----
H
P
E
Q
L
T
V
V
K
A
-
N
P
G
R
T
P
M
A
V
E
E
L
L
R
Y
F
T
-
I
A
-
D
G
-
V
-
T
S
-
R
L
A
T
E
D
V
E
I
G
G
-
V
S
I
K
A
G
E
G
V
I
V
S
M
L
S
A
N
W
D
P
A
V
F
-
K
D
P
A
V
L
D
V
E
R
--
G
A
R
H
H
L
A
F
G
F
G
P
H
Q
C
L
G
Q
N
L
A
R
M
E
L
Q
I
V
F
D
T
L
F
R
R
I
P
S
-
L
R
L
A
V
P
M
E
D
V
P
F
K
G
D
S
V
-
I
Y
G
V
H
E
L
P
V
T
W
----
45
HHSearch
93.90
33%
-110
* C7 *
4MM0
1
?
A:
[8-399]
---
A
T
R
H
P
Y
P
F
D
R
A
V
P
-
T
-
A
I
P
P
L
Y
E
E
L
R
E
T
E
R
V
A
A
I
T
M
A
-
T
G
D
-
P
-
G
F
L
V
T
R
Y
E
D
V
R
F
V
L
S
D
--------------
P
R
F
S
V
--
R
Q
--
D
-
L
P
G
A
P
-------
R
-
L
-----
T
E
M
T
F
----
E
---
S
V
M
T
-----
T
D
-
P
P
--
V
H
T
R
L
R
R
L
L
S
R
D
F
T
A
R
R
I
E
R
M
R
P
R
L
E
E
I
A
E
G
L
L
D
E
-
M
E
K
-
K
G
A
---
P
A
D
I
V
E
S
L
A
V
P
F
P
I
T
V
I
C
-
E
L
L
---
G
V
P
M
V
D
V
A
R
F
R
G
W
A
D
T
M
V
---
S
L
-
T
G
Y
S
M
E
D
W
T
-
A
A
R
D
A
---
L
E
S
Y
L
D
G
L
V
A
A
K
R
E
N
P
G
S
D
L
L
S
A
L
V
A
T
-
A
A
E
D
N
--
E
L
T
D
H
D
V
R
S
L
S
L
I
L
L
L
A
G
Y
E
P
A
S
N
Q
L
G
S
S
V
L
T
L
L
R
----
F
P
D
R
L
A
E
L
R
R
-
D
P
G
L
L
P
S
A
V
E
E
L
M
R
Y
A
P
-
A
G
-
D
G
-
A
-
L
F
-
R
V
T
L
E
D
V
T
I
G
D
-
T
H
I
P
A
N
S
A
V
L
A
S
T
Q
A
A
N
W
D
P
R
R
F
-
D
D
P
T
G
L
R
L
D
R
--
P
D
N
Q
H
T
A
L
G
H
G
I
H
F
C
L
G
A
A
L
A
R
V
E
L
Q
V
A
I
G
A
L
L
R
R
F
-
P
R
L
A
L
A
T
D
E
S
G
L
R
W
S
S
P
G
S
M
L
S
G
F
A
E
I
P
V
T
W
----
2
PsiBlast_PDB
93.52
34%
-103
- C7 -
2Z36
2
?
A:
[14-407]
--------
L
P
V
E
R
G
C
P
-
F
-
A
P
P
A
A
Y
E
R
L
R
E
R
A
P
I
N
K
V
R
L
T
-
S
G
G
-
Q
-
A
W
W
V
S
G
H
E
E
A
R
A
V
L
A
D
--------------
G
R
F
S
S
DK
R
K
--
D
G
F
P
L
F
T
-------
L
-
D
A
--
A
-
T
L
Q
Q
L
R
S
Q
P
P
---
L
M
L
G
-----
M
D
-
G
A
--
E
H
S
A
A
R
R
P
V
I
G
E
F
T
V
K
R
L
A
A
L
R
P
R
I
Q
D
I
V
D
H
F
I
D
D
M
L
A
T
-
D
Q
R
---
P
V
D
L
V
Q
A
L
S
L
P
V
P
S
L
V
I
C
-
E
L
L
---
G
V
-
P
Y
T
D
H
D
F
F
-
Q
S
R
T
T
M
---
M
V
S
R
T
-
S
M
E
D
R
R
-
R
A
F
A
E
---
L
R
A
Y
I
D
D
L
I
T
R
K
E
S
E
P
G
D
D
L
F
S
R
Q
I
A
R
-
Q
R
Q
E
G
--
T
L
D
H
A
G
L
V
S
L
A
F
L
L
L
T
A
G
H
E
T
T
A
N
M
I
S
L
G
V
V
G
L
L
S
----
H
P
E
Q
L
T
V
V
K
A
-
N
P
G
R
T
P
M
A
V
E
E
L
L
R
Y
F
T
-
I
A
-
D
G
-
V
-
T
S
-
R
L
A
T
E
D
V
E
I
G
G
-
V
S
I
K
A
G
E
G
V
I
V
S
M
L
S
A
N
W
D
P
A
V
F
-
K
D
P
A
V
L
D
V
E
R
--
G
A
R
H
H
L
A
F
G
F
G
P
H
Q
C
L
G
Q
N
L
A
R
M
E
L
Q
I
V
F
D
T
L
F
R
R
I
P
S
-
L
R
L
A
V
P
M
E
D
V
P
F
K
G
D
S
V
-
I
Y
G
V
H
E
L
P
V
T
W
----
1
PsiBlast_PDB
93.19
34%
-106
- C7 -
4XE3
11
?
A:
[14-407]
-----
V
P
A
Y
P
F
S
L
P
H
A
-
L
-
D
L
D
P
H
Y
A
E
L
R
R
D
E
P
V
S
R
V
R
L
P
-
Y
G
E
G
T
-
A
W
L
V
T
R
M
S
D
A
R
I
V
L
G
D
--------------
S
R
F
S
T
--
A
A
--
A
T
D
P
A
T
P
-------
R
-
M
F
--
P
-
T
P
P
E
P
----
D
---
G
V
L
A
-----
Q
D
-
P
P
--
D
H
T
R
L
R
R
L
V
G
K
A
F
T
A
R
R
V
E
E
M
R
P
R
V
R
S
L
V
D
S
L
L
D
D
-
M
V
A
-
H
G
S
---
P
A
D
L
V
E
F
L
A
V
P
F
P
V
A
V
I
C
-
E
L
L
---
G
V
P
L
E
D
R
D
L
F
R
T
F
S
D
A
M
L
---
S
S
T
R
L
-
T
A
A
E
I
Q
-
R
V
Q
Q
D
---
F
M
V
Y
M
D
G
L
V
A
Q
R
R
D
A
P
T
E
D
L
L
G
A
L
A
L
A
-
T
D
N
D
D
--
H
L
T
K
G
E
I
V
N
M
G
V
S
L
L
I
A
G
H
E
T
S
V
N
Q
I
T
N
L
V
H
L
L
L
T
----
E
R
K
R
Y
E
S
L
V
A
-
D
P
A
L
V
P
A
A
V
E
E
M
L
R
Y
T
P
-
L
V
-
S
A
G
S
-
F
V
-
R
V
A
T
E
D
V
E
L
S
T
-
V
T
V
R
A
G
E
P
C
V
V
H
F
A
S
A
N
R
D
E
E
V
F
-
D
H
A
D
E
L
D
F
H
R
--
E
R
N
P
H
I
A
F
G
H
G
A
H
H
C
I
G
A
Q
L
G
R
L
E
L
Q
E
A
L
S
A
L
V
R
R
F
P
T
-
L
D
L
A
E
P
V
A
G
L
K
W
K
-
Q
G
M
L
I
R
G
L
E
R
Q
I
V
S
W
----
61
HHSearch
92.04
35%
-106
- C7 -
4XE3
11
?
A:
[22-407]
-------------
P
H
A
-
L
-
D
L
D
P
H
Y
A
E
L
R
R
D
E
P
V
S
R
V
R
L
P
Y
G
E
G
-
T
-
A
W
L
V
T
R
M
S
D
A
R
I
V
L
G
D
--------------
S
R
F
S
T
--
A
A
--
A
T
D
P
A
T
P
-------
R
-
M
F
--
P
-
T
P
P
E
P
----
D
---
G
V
L
A
-----
Q
D
-
P
P
--
D
H
T
R
L
R
R
L
V
G
K
A
F
T
A
R
R
V
E
E
M
R
P
R
V
R
S
L
V
D
S
L
L
D
D
-
M
V
A
-
H
G
S
---
P
A
D
L
V
E
F
L
A
V
P
F
P
V
A
V
I
C
-
E
L
L
---
G
V
P
L
E
D
R
D
L
F
R
T
F
S
D
A
M
L
---
S
S
-
T
R
L
T
A
A
E
I
Q
-
R
V
Q
Q
D
---
F
M
V
Y
M
D
G
L
V
A
Q
R
R
D
A
P
T
E
D
L
L
G
A
L
A
L
A
-
T
D
N
D
D
--
H
L
T
K
G
E
I
V
N
M
G
V
S
L
L
I
A
G
H
E
T
S
V
N
Q
I
T
N
L
V
H
L
L
L
T
----
E
R
K
R
Y
E
S
L
V
A
-
D
P
A
L
V
P
A
A
V
E
E
M
L
R
Y
T
P
-
L
V
-
S
A
-
G
S
F
V
-
R
V
A
T
E
D
V
E
L
S
T
-
V
T
V
R
A
G
E
P
C
V
V
H
F
A
S
A
N
R
D
E
E
V
F
-
D
H
A
D
E
L
D
F
H
R
--
E
R
N
P
H
I
A
F
G
H
G
A
H
H
C
I
G
A
Q
L
G
R
L
E
L
Q
E
A
L
S
A
L
V
R
R
F
-
P
T
L
D
L
A
E
P
V
A
G
L
K
W
K
Q
-
G
M
L
I
R
G
L
E
R
Q
I
V
S
W
----
66
HHSearch
91.84
34%
-103
- C7 -
2Z36
2
?
A:
[19-408]
-------------
G
C
P
-
F
-
A
P
P
A
A
Y
E
R
L
R
E
R
A
P
I
N
K
V
R
L
T
-
S
G
G
-
Q
-
A
W
W
V
S
G
H
E
E
A
R
A
V
L
A
D
--------------
G
R
F
S
S
--
D
K
--
R
-
K
D
G
F
P
LFTLD
A
A
T
-
L
Q
--
Q
-
L
R
S
Q
P
----
P
---
L
M
L
G
-----
M
D
-
G
A
--
E
H
S
A
A
R
R
P
V
I
G
E
F
T
V
K
R
L
A
A
L
R
P
R
I
Q
D
I
V
D
H
F
I
D
D
-
M
L
A
T
D
Q
R
---
P
V
D
L
V
Q
A
L
-
S
L
P
V
P
S
L
V
I
C
E
L
L
---
G
V
P
Y
T
D
H
D
F
F
Q
S
R
T
T
M
M
V
---
S
R
-
T
--
S
M
E
D
R
R
-
R
A
F
A
E
---
L
R
A
Y
I
D
D
L
I
T
R
K
E
S
E
P
G
D
D
L
F
S
R
Q
I
A
R
-
Q
R
Q
E
G
--
T
L
D
H
A
G
L
V
S
L
A
F
L
L
L
T
A
G
H
E
T
T
A
N
M
I
S
L
G
V
V
G
L
L
S
----
H
P
E
Q
L
T
V
V
K
A
-
N
P
G
R
T
P
M
A
V
E
E
L
L
R
Y
F
T
-
I
A
-
D
G
-
V
-
T
S
-
R
L
A
T
E
D
V
E
I
G
G
-
V
S
I
K
A
G
E
G
V
I
V
S
M
L
S
A
N
W
D
P
A
V
F
-
K
D
P
A
V
L
D
V
E
R
--
G
A
R
H
H
L
A
F
G
F
G
P
H
Q
C
L
G
Q
N
L
A
R
M
E
L
Q
I
V
F
D
T
L
F
R
R
I
P
S
-
L
R
L
A
V
P
M
E
D
V
P
F
K
G
-
D
S
V
I
Y
G
V
H
E
L
P
V
T
W
H
---
58
HHSearch
91.50
31%
-102
- C7 -
3ABA
5
?
A:
[7-400]
----
D
A
P
T
V
P
K
A
R
S
C
P
-
F
-
L
P
P
D
G
I
A
D
I
R
A
A
A
P
V
T
R
A
T
F
T
-
S
G
H
-
E
-
A
W
L
V
T
G
Y
E
E
V
R
A
L
L
R
D
--------------
S
S
F
S
V
--
Q
V
--
P
H
A
L
H
T
Q
-------
D
G
V
V
--
T
-
Q
K
P
G
R
----
G
---
S
L
L
W
-----
Q
D
-
E
P
--
E
H
T
S
D
R
K
L
L
A
K
E
F
T
V
R
R
M
Q
A
L
R
P
N
I
Q
R
I
V
D
E
H
L
D
A
-
I
E
A
-
R
G
G
---
P
V
D
L
V
K
T
F
A
N
A
V
P
S
M
V
I
S
-
D
L
F
---
G
V
P
V
E
R
R
A
E
F
Q
D
I
A
E
A
M
M
---
R
V
-
D
Q
-
D
A
A
A
T
E
-
A
A
G
M
R
---
L
G
G
L
L
Y
Q
L
V
Q
E
R
R
A
N
P
G
D
D
L
I
S
A
L
I
T
T
-
E
D
P
D
G
--
V
V
D
D
M
F
L
M
N
A
A
G
T
L
L
I
A
A
H
D
T
T
A
C
M
I
G
L
G
T
A
L
L
L
D
----
S
P
D
Q
L
A
L
L
R
E
-
D
P
S
L
V
G
N
A
V
E
E
L
L
R
Y
L
T
-
I
G
-
Q
F
-
G
-
G
E
-
R
V
A
T
R
D
V
E
L
G
G
-
V
R
I
A
K
G
E
Q
V
V
A
H
V
L
A
A
D
F
D
P
A
F
V
-
E
E
P
E
R
F
D
I
T
R
--
R
P
A
P
H
L
A
F
G
F
G
A
H
Q
C
I
G
Q
Q
L
A
R
I
E
L
Q
I
V
F
E
T
L
F
R
R
L
P
G
-
L
R
L
A
K
P
V
E
E
L
R
F
R
H
-
D
M
V
F
Y
G
V
H
E
L
P
V
T
W
H
---
14
PsiBlast_PDB
91.48
31%
-104
- C7 -
3E5L
1
?
A:
[9-399]
------
P
T
V
P
K
A
R
S
C
P
-
F
-
L
P
P
D
G
I
A
D
I
R
A
A
A
P
V
T
R
A
T
F
T
-
S
G
H
-
E
-
A
W
L
V
T
G
Y
E
E
V
R
A
L
L
R
D
--------------
S
S
F
S
V
--
Q
V
--
P
H
A
L
A
T
Q
-------
D
-
G
V
-----
V
T
Q
K
----
P
G
R
G
S
L
L
W
-----
Q
D
-
E
P
--
E
H
T
S
D
R
K
L
L
A
K
E
F
T
V
R
R
M
Q
A
L
R
P
N
I
Q
R
I
V
D
E
H
L
D
A
-
I
E
A
-
R
G
G
---
P
V
D
L
V
K
T
F
A
N
A
V
P
S
M
V
I
S
-
D
L
F
---
G
V
P
V
E
R
R
A
E
F
Q
D
I
A
E
A
M
M
---
R
V
-----
D
Q
D
A
A
-
A
T
E
A
A
G
M
R
L
G
G
L
L
Y
Q
L
V
Q
E
R
R
A
N
P
G
D
D
L
I
S
A
L
I
T
T
-
E
D
P
D
G
--
V
V
D
D
M
F
L
M
N
A
A
G
T
L
L
I
A
A
H
D
T
T
A
C
M
I
G
L
G
T
A
L
L
L
D
----
S
P
D
Q
L
A
L
L
R
E
-
D
P
S
L
V
G
N
A
V
E
E
L
L
R
Y
L
T
-
I
G
-
Q
F
-
G
-
G
E
-
R
V
A
T
R
D
V
E
L
G
G
-
V
R
I
A
K
G
E
Q
V
V
A
H
V
L
A
A
D
F
D
P
A
F
V
-
E
E
P
E
R
F
D
I
T
R
--
R
P
A
P
H
L
A
F
G
F
G
A
H
Q
C
I
G
Q
Q
L
A
R
I
E
L
Q
I
V
F
E
T
L
F
R
R
L
P
G
-
L
R
L
A
K
P
V
E
E
L
R
F
R
-
H
D
M
V
F
Y
G
V
H
E
L
P
V
T
W
----
35
Fugue
91.38
30%
-116
- C7 -
1GWI
5
?
A:
[8-409]
A
R
I
-
P
L
D
--
P
F
V
T
--
D
-
L
---
D
G
E
S
A
R
L
R
A
A
G
P
L
A
A
V
E
L
P
-
G
G
V
-
P
-
V
W
A
V
T
H
H
A
E
A
K
A
L
L
T
-DPRLVKDINVW
G
A
W
R
R
G
E
I
--
P
A
-------
D
W
-------
P
-
L
I
--
G
-
L
A
N
P
G
----
R
---
S
M
L
T
-----
V
D
G-
A
--
E
H
R
R
L
R
T
L
V
A
Q
A
L
T
V
R
R
V
E
H
M
R
G
R
I
T
E
L
T
D
R
L
L
D
E
-
L
P
----
A
DGG
V
V
D
L
K
A
A
F
A
Y
P
L
P
M
Y
V
V
A
-
D
L
M
GIE---
E
A
R
L
P
R
L
K
V
L
F
E
K
-
F
F
ST---
Q
T
-
P
P
E
E
V
V
-
A
T
L
T
E
---
L
A
S
I
M
T
D
T
V
A
A
K
R
A
A
P
G
D
D
L
T
S
A
L
I
Q
A
--
S
E
N
-G
D
H
L
T
D
A
E
I
V
S
T
L
Q
L
M
V
A
A
G
H
E
T
T
I
S
L
I
V
N
A
V
V
N
L
S
T
----
H
P
E
Q
R
A
L
V
L
S
G-
E
A
E
W
S
A
V
V
E
E
T
L
R
F
S
T
-
P
T
-
S
H
-
V
-
L
I
-
R
F
A
A
E
D
V
P
V
G
-D
R
V
I
P
A
G
D
A
L
I
V
S
Y
G
A
L
G
R
D
E
R
A
H
G
P
T
A
D
R
F
D
L
T
R
TS-
G
N
R
H
I
S
F
G
H
G
P
H
V
C
P
G
A
A
L
S
R
M
E
A
G
V
A
L
P
A
L
Y
A
R
F
P
H
-
L
D
L
A
V
P
A
A
E
L
R
N
K
P
V
V
T
Q
N
D
L
F
E
-
L
P
V
R
L
A
-HH
16
PsiBlast_PDB
91.38
31%
-108
- C7 -
3E5J
1
?
A:
[9-399]
------
P
T
V
P
K
A
R
S
C
P
-
F
-
L
P
P
D
G
I
A
D
I
R
A
A
A
P
V
T
R
A
T
F
T
-
S
G
H
-
E
-
A
W
L
V
T
G
Y
E
E
V
R
A
L
L
R
D
--------------
S
S
F
S
V
--
Q
V
PH
A
L
H
-
T
Q
D
-------
G
-
V
V
-------
G
R
----
G
---
S
L
L
W
-----
Q
D
-
E
P
--
E
H
T
S
D
R
K
L
L
A
K
E
F
T
V
R
R
M
Q
A
L
R
P
N
I
Q
R
I
V
D
E
H
L
D
A
-
I
E
A
-
R
G
G
---
P
V
D
L
V
K
T
F
A
N
A
V
P
S
M
V
I
S
-
D
L
F
---
G
V
P
V
E
R
R
A
E
F
Q
D
I
A
E
A
M
M
---
R
V
-----
D
Q
D
A
A
-
A
T
E
A
A
G
M
R
L
G
G
L
L
Y
Q
L
V
Q
E
R
R
A
N
P
G
D
D
L
I
S
A
L
I
T
T
-
E
D
P
D
G
--
V
V
D
D
M
F
L
M
N
A
A
G
T
L
L
I
A
A
H
D
T
T
A
C
M
I
G
L
G
T
A
L
L
L
D
----
S
P
D
Q
L
A
L
L
R
E
-
D
P
S
L
V
G
N
A
V
E
E
L
L
R
Y
L
T
-
I
G
-
Q
F
-
G
-
G
E
-
R
V
A
T
R
D
V
E
L
G
G
-
V
R
I
A
K
G
E
Q
V
V
A
H
V
L
A
A
D
F
D
P
A
F
V
-
E
E
P
E
R
F
D
I
T
R
--
R
P
A
P
H
L
A
F
G
F
G
A
H
Q
C
I
G
Q
Q
L
A
R
I
E
L
Q
I
V
F
E
T
L
F
R
R
L
P
G
-
L
R
L
A
K
P
V
E
E
L
R
F
R
-
H
D
I
V
F
Y
G
V
H
E
L
P
V
T
W
----
20
PsiBlast_PDB
91.28
30%
-117
- C7 -
2XBK
2
?
A:
[15-404]
-----
L
P
C
L
N
L
E
P
P
K
M
-
L
-
K
L
S
P
L
L
R
A
L
Q
D
R
G
P
I
H
R
V
R
T
P
-
A
G
D
-
E
-
A
W
L
V
T
R
H
A
E
L
K
Q
L
L
H
D
--------------
E
R
I
G
R
--
T
H
--
P
D
P
P
S
A
A
-------
Q
-
Y
V
RS
P
-
F
L
D
L
L
----
I
---
S
D
A
D
-----
A
E
-
S
G
R
R
Q
H
A
E
T
R
R
L
L
T
P
L
F
S
A
R
R
V
L
E
M
Q
P
K
V
E
E
A
A
D
T
L
L
D
A
-
F
I
A
-
Q
G
P
---
P
G
D
L
H
G
E
L
T
V
P
F
A
L
T
V
L
C
-
E
V
I
---
G
V
P
P
Q
R
R
A
E
L
T
T
L
L
---
A
---
G
I
A
K
L
-
D
D
R
E
G
A
V
R
A
Q
D
D
---
L
F
G
Y
V
A
G
L
V
E
H
K
R
A
E
P
G
P
D
I
I
S
R
L
------
N
D
G
--
E
L
T
E
D
R
V
A
H
L
A
M
G
L
L
F
A
G
L
D
S
V
A
S
I
M
D
N
G
V
V
L
L
A
A
----
H
P
D
Q
R
A
A
A
L
A
-
D
P
D
V
M
A
R
A
V
E
E
V
L
R
T
A
R
-
A
G
G
S
V
-
L
-
P
P
-
R
Y
A
S
E
D
M
E
F
G
G
-
V
T
I
R
A
G
D
L
V
L
F
D
L
G
L
P
N
F
D
E
R
A
F
-
T
G
P
E
E
F
D
A
A
R
--
T
P
N
P
H
L
T
F
G
H
G
I
W
H
C
I
G
A
P
L
A
R
L
E
L
R
T
M
F
T
K
L
F
T
R
L
P
E
-
L
R
P
E
L
P
V
E
Q
L
-
R
L
K
E
G
Q
L
S
G
G
F
A
E
L
R
V
V
W
----
46
HHSearch
90.97
31%
-116
- C7 -
2XBK
2
?
A:
[14-404]
----
D
L
P
C
L
N
L
E
P
P
K
M
-
L
-
K
L
S
P
L
L
R
A
L
Q
D
R
G
P
I
H
R
V
R
T
P
-
A
G
D
-
E
-
A
W
L
V
T
R
H
A
E
L
K
Q
L
L
H
D
--------------
E
R
I
G
R
--
T
H
--
P
D
P
P
S
A
A
-------
Q
-
Y
V
----
R
S
P
F
L
----
D
---
L
L
I
S
DAD
A
E
S
G
-
R
R
--
Q
H
A
E
T
R
R
L
L
T
P
L
F
S
A
R
R
V
L
E
M
Q
P
K
V
E
E
A
A
D
T
L
L
D
A
-
F
I
A
-
Q
G
P
---
P
G
D
L
H
G
E
L
T
V
P
F
A
L
T
V
L
C
-
E
V
I
---
G
V
P
P
Q
R
R
A
E
L
T
T
L
L
A
G
I
A
---
K
L
-
D
--
D
R
E
G
A
V
-
R
A
Q
D
D
---
L
F
G
Y
V
A
G
L
V
E
H
K
R
A
E
P
G
P
D
I
I
S
R
L
N
D
G
--------
E
L
T
E
D
R
V
A
H
L
A
M
G
L
L
F
A
G
L
D
S
V
A
S
I
M
D
N
G
V
V
L
L
A
A
----
H
P
D
Q
R
A
A
A
L
A
-
D
P
D
V
M
A
R
A
V
E
E
V
L
R
T
A
R
-
A
G
-
G
S
V
L
-
P
P
-
R
Y
A
S
E
D
M
E
F
G
G
-
V
T
I
R
A
G
D
L
V
L
F
D
L
G
L
P
N
F
D
E
R
A
F
-
T
G
P
E
E
F
D
A
A
R
--
T
P
N
P
H
L
T
F
G
H
G
I
W
H
C
I
G
A
P
L
A
R
L
E
L
R
T
M
F
T
K
L
F
T
R
L
P
E
-
L
R
P
E
L
P
V
E
Q
L
R
L
K
E
-
G
Q
L
S
G
G
F
A
E
L
R
V
V
W
----
26
PsiBlast_CBE
90.92
31%
-118
- C7 -
2D0E
3
C1582_STRCO
A:
[28-404]
----------------------
P
V
L
T
E
L
M
R
E
G
P
V
T
R
I
S
L
P
-
N
G
E
-
G
W
A
W
L
V
T
R
H
D
D
V
R
L
V
T
N
D
--------------
P
R
F
G
R
--
E
A
--
V
M
D
R
Q
V
T
-------
R
-
L
A
--
P
H
F
I
P
A
R
----
G
---
A
V
G
F
-----
L
D
-
P
P
--
D
H
T
R
L
R
R
S
V
A
A
A
F
T
A
R
G
V
E
R
V
R
E
R
S
R
G
M
L
D
E
L
V
D
A
-
M
L
R
-
A
G
P
---
P
A
D
L
T
E
A
V
L
S
P
F
P
I
A
V
I
C
-
E
L
M
---
G
V
P
A
T
D
R
H
S
M
H
T
W
T
Q
L
I
L
---
S
S
S
H
--
G
A
E
V
S
E
-
R
A
K
N
E
---
M
N
A
Y
F
S
D
L
I
G
L
R
S
D
S
A
G
E
D
V
T
S
L
L
G
A
A
V
G
R
D
E
I
--
T
L
S
--
E
A
V
G
L
A
V
L
L
Q
I
G
G
-----
E
A
V
T
N
N
S
G
Q
M
F
H
L
L
L
S
R
P
E
L
A
E
R
L
R
S
-
E
P
E
I
R
P
R
A
I
D
E
L
L
R
W
I
P
-
H
R
-
N
A
-
V
-
G
L
S
R
I
A
L
E
D
V
E
I
K
G
-
V
R
I
R
A
G
D
A
V
Y
V
S
Y
L
A
A
N
R
D
P
E
V
F
-
P
D
P
D
R
I
D
F
E
R
--
S
P
N
P
H
V
S
F
G
F
G
P
H
Y
C
P
G
G
M
L
A
R
L
E
S
E
L
L
V
D
A
V
L
D
R
V
P
G
-
L
K
L
A
V
A
P
E
D
V
P
F
K
-
K
G
A
L
I
R
G
P
E
A
L
P
V
T
W
----
9
PsiBlast_PDB
90.91
29%
-114
- C7 -
2YGX
6
MYCG_MICGR
A:
[25-417]
----
E
P
R
A
Y
P
F
N
D
V
H
G
-
L
-
T
L
A
G
R
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
-
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
--------------
G
R
F
-
V
--
R
G
--
P
S
M
T
R
D
E
-------
P
-
R
T
--
R
-
P
E
M
V
K
----
G
---
G
L
L
S
-----
M
D
-
P
P
--
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
A
A
-
T
G
Q
---
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
-
E
L
L
---
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
---
S
T
A
E
V
-
T
A
E
E
M
Q
-
E
A
A
E
Q
---
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
Q
D
--
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
----
R
P
E
L
R
R
Q
L
L
D
-
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
V
-
G
T
-
A
-
F
P
-
R
Y
A
V
E
D
V
T
L
R
G
-
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
-
P
D
A
D
R
I
D
V
D
R
--
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
-
I
R
L
G
I
P
E
T
Q
L
-
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
----