@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3356c: (2016-05-19 )
MGAIMLDGKATRDEIFGDLKQRVAALDAAGRTPGLGTILVGDDPGSQAYVRGKHADCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPLPKHLDENAALERVDPAKDADGLHPTNLGRLVLGTPAPLPCTPRGIVHLLRRYDISIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLPALTRQADIVVAAVGVAHLLTADMVRPGAAVIDVGVSRTDDGLVGDVHPDVWELAGHVSPNPGGVGPLTRAFLLTNVVELAERR
Atome Classification :
(35 SA)
.........10........20......--.--.--30.-----........40........50........60........70........80........90........100..--.-......110.......120.......130.--.--.--..-.--.-.140.......150.......160-.........170.......180.......190.--.--.--....200.......210.......220.......230.------...-.-------.-------.-240..-.-..-.-.250.......260.......270.......280-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
G
A
I
M
LDGKA
T
R
D
E
I
F
G
D
L
K
Q
R
V
A
A
L
D--A--A--G-R-----TPG
L
G
T
I
L
V
GDDPGSQ
A
Y
V
RGKHA
D
C
A
K
V
G
I
T
S
I
R
R
DLPADIS
T
A
T
L
N
E
T
I
D
E
LNANPDC
T
G
Y
I
V
QLPL--PK--H-LDENAALERVDPAKDADGLHPTNL
G
R
L
-
V
L--G--T--PA-P--L-PCT
P
R
G
I
V
H
L
L
R
R
YDISIAG
A
H
---
V
V
V
I
GRGVTVGRP
L
G
L
L
L
TRRSEN
A
T
V
T
L
C
HTG--T--R--D
L
P
A
L
TRQA
D
I
V
V
A
A
V
G
V
A
H
L
L
T
A
D
MVRPG
A
A
V
I
D
VGV------SRT-D-------D-------G-LVGDV-H-P
D
-
V
-
W
E
L
AGHVSPNPGG
V
G
P
L
T
R
A
F
L
L
T
N
V
V
E
L
AERR------
33
HHSearch
97.46
100%
-116
- C8 -
2C2X
-
FOLD_MYCTU
A:
[2-281]
-
G
A
I
M
L
D
G
K
A
T
R
D
E
I
F
G
D
L
K
Q
R
V
A
A
L
D
--
A
--
A
--
G
-
R
-----
T
P
G
L
G
T
I
L
V
G
D
D
P
G
S
Q
A
Y
V
R
G
K
H
A
D
C
A
K
V
G
I
T
S
I
R
R
D
L
P
A
D
I
S
T
A
T
L
N
E
T
I
D
E
L
N
A
N
P
D
C
T
G
Y
I
V
Q
L
P
L
--
P
K
--
H
-
L
D
E
N
A
A
L
E
R
V
D
P
A
K
D
A
D
G
L
H
P
T
N
L
G
R
L
-
V
L
--
G
--
T
--
P
A
-
P
--
L
-
P
C
T
P
R
G
I
V
H
L
L
R
R
Y
D
I
S
I
A
G
A
H
---
V
V
V
I
G
R
G
V
T
V
G
R
P
L
G
L
L
L
T
R
R
S
E
N
A
T
V
T
L
C
H
T
G
--
T
--
R
--
D
L
P
A
L
T
R
Q
A
D
I
V
V
A
A
V
G
V
A
H
L
L
T
A
D
M
V
R
P
G
A
A
V
I
D
V
G
V
------
S
R
T
-
D
-------
D
-------
G
-
L
V
G
D
V
-
H
-
P
D
-
V
-
W
E
L
A
G
H
V
S
P
N
P
G
G
V
G
P
L
T
R
A
F
L
L
T
N
V
V
E
L
A
E
R
R
------
1
PsiBlast_PDB
97.25
99%
-116
- C8 -
2C2X
-
FOLD_MYCTU
A:
[2-281]
-
G
A
I
M
L
D
G
K
A
T
R
D
E
I
F
G
D
L
K
Q
R
V
A
A
L
D
--
A
--
A
--
G
-
R
-----
T
P
G
L
G
T
I
L
V
G
D
D
P
G
S
Q
A
Y
V
R
G
K
H
A
D
C
A
K
V
G
I
T
S
I
R
R
D
L
P
A
D
I
S
T
A
T
L
N
E
T
I
D
E
L
N
A
N
P
D
C
T
G
Y
I
V
Q
L
P
L
--
P
K
--
H
-
L
D
E
N
A
A
L
E
R
V
D
P
A
K
D
A
D
G
L
H
P
T
N
L
G
R
L
-
V
L
--
G
--
T
--
P
A
-
P
--
L
-
P
C
T
P
R
G
I
V
H
L
L
R
R
Y
D
I
S
I
A
G
A
H
---
V
V
V
I
G
R
G
V
T
V
G
R
P
L
G
L
L
L
T
R
R
S
E
N
A
T
V
T
L
C
H
T
G
--
T
--
R
--
D
L
P
A
L
T
R
Q
A
D
I
V
V
A
A
V
G
V
A
H
L
L
T
A
D
M
V
R
P
G
A
A
V
I
D
V
G
V
------
S
R
T
-
D
-------
D
-------
G
-
L
V
G
D
V
-
H
-
P
D
-
V
-
W
E
L
A
G
H
V
S
P
N
P
G
G
V
G
P
L
T
R
A
F
L
L
T
N
V
V
E
L
A
E
R
R
------
2
PsiBlast_PDB
96.66
99%
-116
- C8 -
2C2Y
-
FOLD_MYCTU
A:
[2-281]
-
G
A
I
M
L
D
G
K
A
T
R
D
E
I
F
G
D
L
K
Q
R
V
A
A
L
D
--
A
--
A
--
G
-
R
-----
T
P
G
L
G
T
I
L
V
G
D
D
P
G
S
Q
A
Y
V
R
G
K
H
A
D
C
A
K
V
G
I
T
S
I
R
R
D
L
P
A
D
I
S
T
A
T
L
N
E
T
I
D
E
L
N
A
N
P
D
C
T
G
Y
I
V
Q
L
P
L
--
P
K
--
H
-
L
D
E
N
A
A
L
E
R
V
D
P
A
K
D
A
D
G
L
H
P
T
N
L
G
R
L
-
V
L
--
G
--
T
--
P
A
-
P
--
L
-
P
C
T
P
R
G
I
V
H
L
L
R
R
Y
D
I
S
I
A
G
A
H
---
V
V
V
I
G
R
G
V
T
V
G
R
P
L
G
L
L
L
T
R
R
S
E
N
A
T
V
T
L
C
H
T
G
--
T
--
R
--
D
L
P
A
L
T
R
Q
A
D
I
V
V
A
A
V
G
V
A
H
L
L
T
A
D
M
V
R
P
G
A
A
V
I
D
V
G
V
------
S
R
T
-
D
-------
D
-------
G
-
L
V
G
D
V
-
H
-
P
D
-
V
-
W
E
L
A
G
H
V
S
P
N
P
G
G
V
G
P
L
T
R
A
F
L
L
T
N
V
V
E
L
A
E
R
R
------
32
HHSearch
82.96
45%
-107
- C8 -
4B4U
9
?
A:
[22-301]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
--
A
K
-
T
--
G
-
R
-----
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
A
-
Y
--
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
---
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
--
A
N
A
T
V
T
I
C
H
S
R
--
T
--
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-
D
-------
G
-------
G
-
G
V
G
D
I
-
Q
-
L
Q
G
I
-
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
------
21
PsiBlast_CBE
82.91
44%
-111
- C8 -
4B4W
3
?
B:
[23-300]
--
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
--
A
K-
T
--
G
-
R
-----
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
A
-
Y
--
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
---
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
--
A
N
A
T
V
T
I
C
H
S
R
--
T
--
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-
D
-------
G
-------
G
-
G
V
G
D
I
-
Q
L
Q
G
-
I
-
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
-------
23
PsiBlast_CBE
82.88
44%
-113
- C8 -
4B4U
7
?
B:
[23-300]
--
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
--
A
K
-
T
--
G
-
R
-----
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
A
-
Y
--
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
---
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
--
A
N
A
T
V
T
I
C
H
S
R
--
T
--
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-
D
-------
G
-------
G
-
G
V
G
D
I
-
Q
L
Q
G
-
I
-
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
-------
35
HHSearch
82.61
42%
-109
- C8 -
3P2O
2
FOLD_CAMJE
A:
[2-283]
N
A
M
T
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
K
--
S
--
K
--
G
-
I
-----
E
S
C
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
--
P
D
--
H
-
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
-
N
L
--
G
--
L
E-
S
G
-
F
--
L
-
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
K
D
---
A
V
I
I
G
A
S
N
I
V
G
R
P
M
A
T
M
L
L
N
--
A
G
A
T
V
S
V
C
H
I
K
--
T
--
K
--
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
I
------
N
R
L
E
S
-------
G
-------
K
-
I
V
G
D
V
-
D
-
F
E
E
V
-
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
V
K
S
A
K
N
R
------
9
PsiBlast_PDB
82.61
42%
-112
- C8 -
3P2O
2
FOLD_CAMJE
A:
[6-283]
----
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
K
--
S
--
K
--
G
-
I
-----
E
S
C
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
--
P
D
--
H
-
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
-
N
L
--
G
--
L
--
E
S
G
F
--
L
-
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
K
D
---
A
V
I
I
G
A
S
N
I
V
G
R
P
M
A
T
M
L
L
N
A
G
--
A
T
V
S
V
C
H
I
K
--
T
--
K
--
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
I
------
N
R
L
-
E
-------
S
-------
G
K
I
V
G
D
V
D
F
-
E
E
-
V
-
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
V
K
S
A
K
N
R
------
4
PsiBlast_PDB
82.59
44%
-112
- C8 -
4B4V
4
?
A:
[23-300]
--
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
--
A
K
-
T
--
G
-
R
-----
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
A
-
Y
--
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
---
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
--
A
N
A
T
V
T
I
C
H
S
R
--
T
--
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-
D
-------
G
-------
G
-
G
V
G
D
I
-
Q
L
Q
G
-
I
-
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
-------
22
PsiBlast_CBE
82.39
44%
-112
- C8 -
4B4V
3
?
B:
[23-300]
--
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
--
A
K-
T
--
G
-
R
-----
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
A
-
Y
--
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
---
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
--
A
N
A
T
V
T
I
C
H
S
R
--
T
--
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-
D
-------
G
-------
G
-
G
V
G
D
I
-
Q
L
Q
G
-
I
-
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
-------
3
PsiBlast_PDB
82.35
44%
-111
- C8 -
4B4U
9
?
A:
[23-300]
--
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
--
A
K
-
T
--
G
-
R
-----
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
A
-
Y
--
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
---
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
--
A
N
A
T
V
T
I
C
H
S
R
--
T
--
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-
D
-------
G
-------
G
-
G
V
G
D
I
-
Q
L
Q
G
-
I
-
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
-------
5
PsiBlast_PDB
81.48
44%
-108
- C8 -
4B4W
4
?
A:
[23-300]
--
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
--
A
K
-
T
--
G
-
R
-----
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
A
-
Y
--
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
---
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
--
A
N
A
T
V
T
I
C
H
S
R
--
T
--
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-
D
-------
G
-------
G
-
G
V
G
D
I
-
Q
L
Q
G
-
I
-
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
-------
38
HHSearch
80.88
46%
-107
- C8 -
4A26
1
?
A:
[5-296]
-
S
A
Q
I
I
D
G
K
A
I
A
A
A
I
R
S
E
L
K
D
K
V
A
A
L
R
--
E
L
Y
G
--
G
-
R
-----
V
P
G
L
A
S
I
I
V
G
Q
R
M
D
S
K
K
Y
V
Q
L
K
H
K
A
A
A
E
V
G
M
A
S
F
N
V
E
L
P
E
D
I
S
Q
E
V
L
E
V
N
V
E
K
L
N
N
D
P
N
C
H
G
I
I
V
Q
L
P
L
--
P
K
--
H
-
L
N
E
N
R
A
I
E
K
I
H
P
H
K
D
A
D
A
L
L
P
V
N
V
G
L
L
-
H
Y
--
K
--
G
RE
P
P
-
F
--
T
-
P
C
T
A
K
G
V
I
V
L
L
K
R
C
G
I
E
M
A
G
K
R
---
A
V
V
L
G
R
S
N
I
V
G
A
P
V
A
A
L
L
M
K
--
E
N
A
T
V
T
I
V
H
S
G
--
T
S
T
E
--
D
M
I
D
Y
L
R
T
A
D
I
V
I
A
A
M
G
Q
P
G
Y
V
K
G
E
W
I
K
E
G
A
A
V
V
D
V
G
T
------
T
P
V
-
P
DPSRKDG
Y
-------
R
-
L
V
G
D
V
-
C
-
F
E
E
A
-
A
A
R
A
A
W
I
S
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
L
E
A
F
K
A
A
------
24
PsiBlast_CBE
80.63
46%
-114
- C8 -
4A26
1
?
B:
[6-291]
--
A
Q
I
I
D
G
K
A
I
A
A
A
I
R
S
E
L
K
D
K
V
A
A
L
R
--
E
L
Y
G
--
G
-
R
-----
V
P
G
L
A
S
I
I
V
G
Q
R
M
D
S
K
K
Y
V
Q
L
K
H
K
A
A
A
E
V
G
M
A
S
F
N
V
E
L
P
E
D
I
S
Q
E
V
L
E
V
N
V
E
K
L
N
N
D
P
N
C
H
G
I
I
V
Q
L
P
L
--
P
K
--
H
-
L
N
E
N
R
A
I
E
K
I
H
P
H
K
D
A
D
A
L
L
P
V
N
V
G
L
L
H
Y
K
--
G
--
R
--
E
P
-
P
--
F
T
P
C
T
A
K
G
V
I
V
L
L
K
R
C
G
I
E
M
A
G
K
R
---
A
V
V
L
G
R
S
N
I
V
G
A
P
V
A
A
L
L
M
K
--
E
N
A
T
V
T
I
V
H
S
G
TS
T
--
E
--
D
M
I
D
Y
L
R
T
A
D
I
V
I
A
A
M
G
Q
P
G
Y
V
K
G
E
W
I
K
E
G
A
A
V
V
D
V
G
T
T
P
V
PDP
S
-----------
G
-------
Y
R
L
V
G
D
V
C
F
-
E
E
-
A
-
A
A
R
A
A
W
I
S
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
L
E
-----------
26
PsiBlast_CBE
80.19
40%
-106
- C8 -
4CJX
2
?
B:
[25-314]
--
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
RR
Y
--
K
--
G
-
R
-----
R
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
--
P
P
--
H
-
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
-
H
I
RE
R
--
N
--
P
A
-
I
--
V
-
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
K
R
---
V
V
V
L
G
R
G
D
I
A
G
L
P
V
A
T
L
L
A
--
N
E
D
A
T
V
T
V
V
H
S
A
--
T
PL
C
--
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
------
T
P
V
-
A
-------
D
PSKVPGY
R
-
L
V
G
D
V
-
C
-
F
D
-
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
T
M
F
K
R
-------
6
PsiBlast_PDB
80.14
46%
-116
- C8 -
4A26
1
?
A:
[6-291]
--
A
Q
I
I
D
G
K
A
I
A
A
A
I
R
S
E
L
K
D
K
V
A
A
L
R
--
E
L
Y
G
--
G
-
R
-----
V
P
G
L
A
S
I
I
V
G
Q
R
M
D
S
K
K
Y
V
Q
L
K
H
K
A
A
A
E
V
G
M
A
S
F
N
V
E
L
P
E
D
I
S
Q
E
V
L
E
V
N
V
E
K
L
N
N
D
P
N
C
H
G
I
I
V
Q
L
P
L
--
P
K
--
H
-
L
N
E
N
R
A
I
E
K
I
H
P
H
K
D
A
D
A
L
L
P
V
N
V
G
L
L
H
Y
K
--
G
--
R
--
E
P
-
P
--
F
T
P
C
T
A
K
G
V
I
V
L
L
K
R
C
G
I
E
M
A
G
K
R
---
A
V
V
L
G
R
S
N
I
V
G
A
P
V
A
A
L
L
M
K
--
E
N
A
T
V
T
I
V
H
S
G
TS
T
--
E
--
D
M
I
D
Y
L
R
T
A
D
I
V
I
A
A
M
G
Q
P
G
Y
V
K
G
E
W
I
K
E
G
A
A
V
V
D
V
G
T
T
P
V
PDP
S
R
K
-
D
-------
G
-------
Y
R
L
V
G
D
V
C
F
-
E
E
-
A
-
A
A
R
A
A
W
I
S
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
L
E
-----------
8
PsiBlast_PDB
79.84
46%
-99
- C8 -
4A5O
2
FOLD_PSEAE
A:
[4-282]
-
T
A
Q
L
I
D
G
K
A
I
A
A
N
L
R
Q
Q
I
A
Q
R
V
T
E
R
R
--
Q
--
Q
--
G
L
R
-----
V
P
G
L
A
V
I
L
V
G
T
D
P
A
S
Q
V
Y
V
A
H
K
R
K
D
C
E
E
V
G
F
L
S
Q
A
Y
D
L
P
A
E
T
S
Q
D
D
L
L
A
L
I
D
R
L
N
D
D
P
A
I
D
G
I
L
V
Q
L
P
L
--
P
A
--
H
-
L
D
A
S
L
L
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
I
G
R
L
-
A
Q
--
R
--
M
--
P
L
-
L
--
R
-
P
C
T
P
K
G
I
M
T
L
L
A
S
T
G
A
D
L
Y
G
M
D
---
A
V
V
V
G
A
S
N
I
V
G
R
P
M
A
L
E
L
L
--
L
G
G
C
T
V
T
V
T
H
R
F
--
T
--
R
--
D
L
A
D
H
V
S
R
A
D
L
V
V
V
A
A
G
K
P
G
L
V
K
G
E
W
I
K
E
G
A
I
V
I
D
V
G
I
------
N
R
Q
-
A
-------
D
-------
G
R
L
V
G
D
V
-
E
-
Y
E
-
V
A
A
Q
R
A
S
W
I
T
P
V
P
G
G
V
G
P
M
T
R
A
C
L
L
E
N
T
L
H
A
A
E
--------
52
Fugue
79.73
44%
-108
* C8 *
1B0A
-
FOLD_ECOLI
A:
[2-288]
-
A
A
K
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
I
--
A
--
A
G-
L
-
R
-----
A
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
--
P
A
---G
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
-
C
Q
--
R
--
A
--
P
---RL
R
-
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
L
N
---
A
V
V
I
G
A
S
N
I
V
G
R
P
M
S
M
E
L
L
L
A
--
G
C
T
T
T
V
T
H
R
F
--
T
--
K
--
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
I
------
N
R
L
-
E
-------
N
-------
G
K
V
V
G
D
V
V
F
-
E
D
-
A
-
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
L
Q
A
C
V
E
Y
HDPQDE
34
HHSearch
79.73
46%
-99
- C8 -
4A5O
2
FOLD_PSEAE
A:
[4-284]
-
T
A
Q
L
I
D
G
K
A
I
A
A
N
L
R
Q
Q
I
A
Q
R
V
T
E
R
R
--
Q
Q
-
G
--
L
-
R
-----
V
P
G
L
A
V
I
L
V
G
T
D
P
A
S
Q
V
Y
V
A
H
K
R
K
D
C
E
E
V
G
F
L
S
Q
A
Y
D
L
P
A
E
T
S
Q
D
D
L
L
A
L
I
D
R
L
N
D
D
P
A
I
D
G
I
L
V
Q
L
P
L
--
P
A
--
H
-
L
D
A
S
L
L
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
I
G
R
L
-
A
Q
--
R
--
M
--
P
L
-
L
--
R
-
P
C
T
P
K
G
I
M
T
L
L
A
S
T
G
A
D
L
Y
G
M
D
---
A
V
V
V
G
A
S
N
I
V
G
R
P
M
A
L
E
L
L
L
--
G
G
C
T
V
T
V
T
H
R
F
--
T
--
R
--
D
L
A
D
H
V
S
R
A
D
L
V
V
V
A
A
G
K
P
G
L
V
K
G
E
W
I
K
E
G
A
I
V
I
D
V
G
I
------
N
R
Q
A
D
-------
G
-------
R
-
L
V
G
D
V
-
E
-
Y
E
V
A
-
A
Q
R
A
S
W
I
T
P
V
P
G
G
V
G
P
M
T
R
A
C
L
L
E
N
T
L
H
A
A
E
H
L
------
36
HHSearch
79.21
42%
-106
- C8 -
4CJX
4
?
A:
[25-315]
--
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
--
R
R
Y
K
--
G
-
R
-----
R
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
--
P
P
--
H
-
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
-
H
I
--
R
--
E
RN
P
A
-
I
--
V
-
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
K
R
---
V
V
V
L
G
R
G
D
I
A
G
L
P
V
A
T
L
L
A
N
--
E
D
A
T
V
T
V
V
H
S
A
--
T
--
P
L
C
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
------
T
P
V
-
A
D------
P
SKVPG
Y
-
R
-
L
V
G
D
V
-
C
-
F
D
V
A
-
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
T
M
F
K
R
S
------
11
PsiBlast_PDB
78.92
40%
-104
- C8 -
4CJX
4
?
A:
[25-314]
--
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
R
R
Y
--
K
--
G
-
R
-----
R
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
--
P
P
--
H
-
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
-
H
I
RE
R
--
N
--
P
A
-
I
--
V
-
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
K
R
---
V
V
V
L
G
R
G
D
I
A
G
L
P
V
A
T
L
L
A
--
N
E
D
A
T
V
T
V
V
H
S
A
--
T
P
L
C
--
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
------
T
P
V
-
A
-------
D
PSKVPG
Y
R
-
L
V
G
D
V
-
C
-
F
D
-
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
T
M
F
K
R
-------
25
PsiBlast_CBE
78.07
42%
-110
- C8 -
3L07
4
FOLD_FRATT
B:
[5-282]
---
I
L
I
D
G
K
S
----
L
S
K
D
L
K
E
R
L
A
T
Q
V
--
Q
--
E
--
Y
-
K
H
H
TAI
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
--
P
A
--
H
-
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
-
Q
L
--
R
--
D
--
K
K
-
C
--
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
---
A
V
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
--
N
A
K
A
T
V
T
T
C
H
R
F
--
T
--
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
------
N
H
V
-
D
-------
G
-------
K
-
I
V
G
D
V
D
F
-
A
A
-
V
-
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
E
-------
37
HHSearch
77.95
42%
-105
- C8 -
3L07
4
FOLD_FRATT
A:
[3-283]
-
A
M
I
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
--
H
H
-
T
--
A
-
I
-----
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
--
P
A
--
H
-
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
-
Q
L
--
R
--
D
K-
K
C
-
L
--
E
-
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
---
A
V
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
N
--
A
K
A
T
V
T
T
C
H
R
F
--
T
--
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
------
N
H
V
-
D
-------
G
-------
K
-
I
V
G
D
V
-
D
-
F
A
A
V
-
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
E
L
------
10
PsiBlast_PDB
77.69
42%
-110
- C8 -
3L07
4
FOLD_FRATT
A:
[5-282]
---
I
L
I
D
G
K
S
----
L
S
K
D
L
K
E
R
L
A
T
Q
V
--
Q
--
E
--
Y
-
K
H
H
TA
I
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
--
P
A
--
H
-
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
-
Q
L
--
R
--
D
--
K
K
-
C
--
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
---
A
V
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
--
N
A
K
A
T
V
T
T
C
H
R
F
--
T
--
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
------
N
H
V
-
D
-------
G
-------
K
-
I
V
G
D
V
D
F
-
A
A
-
V
-
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
E
-------
31
PsiBlast_CBE
76.41
35%
-105
- C8 -
1A4I
1
C1TC_HUMAN
B:
[4-293]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
--
E
--
Q
VP
G
-
F
-----
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
C
-
F
--
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
---
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
--
N
A
T
V
T
T
C
H
S
K
--
T
--
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
V
-
P
-------
D
DKKPNGR
K
-
V
V
G
D
V
A
Y
-
D
E
-
A
-
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
-------
29
PsiBlast_CBE
76.32
35%
-109
- C8 -
1DIB
1
C1TC_HUMAN
B:
[4-293]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
--
E
--
Q
VP
G
-
F
-----
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
C
-
F
--
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
---
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
--
N
A
T
V
T
T
C
H
S
K
--
T
--
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
V
-
P
-------
D
DKKPNGR
K
-
V
V
G
D
V
A
Y
-
D
E
-
A
-
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
-------
17
PsiBlast_PDB
76.06
35%
-103
- C8 -
1A4I
1
C1TC_HUMAN
A:
[4-293]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
--
E
--
Q
V
P
G
-
F
-----
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
C
-
F
--
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
---
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
--
N
A
T
V
T
T
C
H
S
K
--
T
--
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
------------------
K
-
V
V
G
D
V
A
Y
-
D
E
-
A
-
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
-------
28
PsiBlast_CBE
75.76
35%
-107
- C8 -
1DIG
2
C1TC_HUMAN
B:
[4-293]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
--
E
--
Q
VP
G
-
F
-----
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
C
-
F
--
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
---
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
--
N
A
T
V
T
T
C
H
S
K
--
T
--
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
V
-
P
-------
D
DKKPNGR
K
-
V
V
G
D
V
A
Y
-
D
E
-
A
-
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
-------
39
HHSearch
75.67
37%
-98
- C8 -
1A4I
1
C1TC_HUMAN
A:
[2-294]
A
P
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
--
E
Q
V
P
--
G
-
F
-----
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
--
D
S
EN
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
--
D
LN
D
C
-
F
--
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
---
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
--
N
N
A
T
V
T
T
C
H
S
K
--
T
--
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
------------------
K
-
V
V
G
D
V
-
A
-
Y
D
E
A
-
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
------
15
PsiBlast_PDB
75.54
35%
-105
- C8 -
1DIB
2
C1TC_HUMAN
A:
[4-293]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
--
E
--
Q
VP
G
-
F
-----
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
C
-
F
--
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
---
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
--
N
A
T
V
T
T
C
H
S
K
--
T
--
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
------------------
K
-
V
V
G
D
V
A
Y
-
D
E
-
A
-
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
-------
16
PsiBlast_PDB
75.36
35%
-106
- C8 -
1DIG
2
C1TC_HUMAN
A:
[4-293]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
--
E
--
Q
VP
G
-
F
-----
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
C
-
F
--
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
---
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
--
N
A
T
V
T
T
C
H
S
K
--
T
--
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
------------------
K
-
V
V
G
D
V
A
Y
-
D
E
-
A
-
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
-------
30
PsiBlast_CBE
75.35
35%
-106
- C8 -
1DIA
1
C1TC_HUMAN
B:
[4-293]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
--
E
--
Q
VP
G
-
F
-----
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
C
-
F
--
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
---
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
--
N
A
T
V
T
T
C
H
S
K
--
T
--
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
V
-
P
-------
D
DKKPNGR
K
-
V
V
G
D
V
A
Y
-
D
E
-
A
-
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
-------
14
PsiBlast_PDB
74.86
35%
-105
- C8 -
1DIA
2
C1TC_HUMAN
A:
[4-293]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
--
E
--
Q
VP
G
-
F
-----
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
C
-
F
--
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
---
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
--
N
A
T
V
T
T
C
H
S
K
--
T
--
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
------------------
K
-
V
V
G
D
V
A
Y
-
D
E
-
A
-
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
-------
12
PsiBlast_PDB
72.61
36%
-113
- C8 -
3NGL
1
FOLD_THEAC
A:
[21-270]
-------------------------
I
E
--
R
--
S
--
G
-
L
-----
E
P
S
L
K
L
I
Q
I
G
D
N
E
A
A
S
I
Y
A
R
A
K
I
R
R
G
K
K
I
G
I
-
A
V
D
L
E
K
Y
D
D
I
S
M
K
D
L
L
K
R
I
D
D
L
A
K
D
P
Q
I
N
G
I
M
I
E
N
P
L
--
P
K
--
G
-
F
D
Y
Y
E
I
V
R
N
I
P
Y
Y
K
D
V
D
A
L
S
P
Y
N
Q
G
L
I
-
A
L
--
N
--
R
--
E
F
-
L
--
V
-
P
A
T
P
R
A
V
I
D
I
M
D
Y
Y
-----
G
Y
H
E
N
T
V
T
I
V
N
R
S
P
V
V
G
R
P
L
S
M
M
L
L
N
R
--
N
Y
T
V
S
V
C
H
S
K
--
T
--
K
--
D
I
G
S
M
T
R
S
S
K
I
V
V
V
A
V
G
R
P
G
F
L
N
R
E
M
V
T
P
G
S
V
V
I
D
V
G
I
------
N
Y
V
-
N
-------
D
-------
K
-
V
V
G
D
A
-
N
F
E
D
-
L
-
S
E
Y
V
E
A
I
T
P
V
P
G
G
V
G
P
I
T
A
T
N
I
L
E
N
V
V
K
A
A
E
--------
27
PsiBlast_CBE
71.31
36%
-112
- C8 -
3NGL
1
FOLD_THEAC
C:
[21-270]
-------------------------
I
E
--
R
--
S
--
G
-
L
-----
E
P
S
L
K
L
I
Q
I
G
D
N
E
A
A
S
I
Y
A
R
A
K
I
R
R
G
K
K
I
G
I
-
A
V
D
L
E
K
Y
D
D
I
S
M
K
D
L
L
K
R
I
D
D
L
A
K
D
P
Q
I
N
G
I
M
I
E
N
P
L
--
P
K
--
G
-
F
D
Y
Y
E
I
V
R
N
I
P
Y
Y
K
D
V
D
A
L
S
P
Y
N
Q
G
L
I
-
A
L
--
N
--
R
--
E
F
-
L
--
V
-
P
A
T
P
R
A
V
I
D
I
M
D
Y
Y
-----
G
Y
H
ENT
V
T
I
V
N
R
S
P
V
V
G
R
P
L
S
M
M
L
L
N
R
--
N
Y
T
V
S
V
C
H
S
K
--
T
--
K
--
D
I
G
S
M
T
R
S
S
K
I
V
V
V
A
V
G
R
P
G
F
L
N
R
E
M
V
T
P
G
S
V
V
I
D
V
G
I
------
N
Y
V
-
N
-------
D
-------
K
-
V
V
G
D
A
-
N
F
E
D
-
L
-
S
E
Y
V
E
A
I
T
P
V
P
G
G
V
G
P
I
T
A
T
N
I
L
E
N
V
V
K
A
A
E
--------