@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3568c: (2016-05-21 )
MSIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRMDDFPARLVVVPGEHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEATAAELADRRVDEMIRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQGMGHVVLSTRDDAEALHFYRDVLGFRLRDSMRLPPQMVGRPADGPPAWLRFFGCNPRHHSLAFLPMPTSSGIVHLMVEVEQADDVGLCLDRALRRKVPMSATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVDDRDWIARESTAVSLWGHDFTVGARG
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120...-....130---.-.--......140.......150.......160.......170.........180.......190.......200.......210.......220.......230.......240.......250.......260-.......270.......280.......290.......300
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSI
R
S
L
G
Y
L
R
I
EA
T
D
M
A
A
W
R
E
YG
L
K
V
L
G
M
VEGKGAPE
G
A
L
Y
L
R
MDDFP
A
R
L
V
V
VPGEH
D
R
L
L
E
AGWECA
N
A
E
G
L
Q
E
I
R
N
RLDLEGTPYKE
A
T
A
A
E
L
A
D
R
R
V
D
E
M
I
RFADPSGN
C
L
E
V
FHGTALEH-RRVVSP----Y-G--
H
R
FVTGEQGM
G
H
V
V
L
STRD
D
A
E
A
L
H
F
Y
R
D
V
L
G
F
R
L
RD--SMRL
P
P
Q
MVGRPADG
P
P
A
W
L
R
FFGCNPRHH
S
L
A
F
L
PMPTSS
G
I
V
H
L
M
V
E
V
EQAD
D
V
G
L
C
L
D
R
A
L
R
RKVPM
S
A
T
L
G
R
H
V
N
D
L
M
L
S
F
Y
MKTPGG-
F
D
I
E
FGCEGRQVD
D
R
D
WIARES
T
A
V
S
L
WG
H
D
F
TVGARG
21
PsiBlast_CBE
99.16
100%
-112
- C2 -
2ZYQ
2
HSAC_MYCTU
B:
[2-297]
-
S
I
R
S
L
G
Y
L
R
I
E
A
T
D
M
A
A
W
R
E
Y
G
L
K
V
L
G
M
V
E
G
K
G
A
P
E
G
A
L
Y
L
R
M
D
D
F
P
A
R
L
V
V
V
P
G
E
H
D
R
L
L
E
A
G
W
E
C
A
N
A
E
G
L
Q
E
I
R
N
R
L
D
L
E
G
T
P
Y
K
E
A
T
A
A
E
L
A
D
R
R
V
D
E
M
I
R
F
A
D
P
S
G
N
C
L
E
V
F
H
G
T
A
L
E
H
-
R
R
V
V
S
P
----
Y
-
G
--
H
R
F
V
T
G
E
Q
G
M
G
H
V
V
L
S
T
R
D
D
A
E
A
L
H
F
Y
R
D
V
L
G
F
R
L
R
D
--
S
M
R
L
P
P
Q
M
V
G
R
P
A
D
G
P
P
A
W
L
R
F
F
G
C
N
P
R
H
H
S
L
A
F
L
P
M
P
T
S
S
G
I
V
H
L
M
V
E
V
E
Q
A
D
D
V
G
L
C
L
D
R
A
L
R
R
K
V
P
M
S
A
T
L
G
R
H
V
N
D
L
M
L
S
F
Y
M
K
T
P
G
G
-
F
D
I
E
F
G
C
E
G
R
Q
V
D
D
R
D
W
I
A
R
E
S
T
A
V
S
L
W
G
H
D
F
T
V
G
---
41
HHSearch
98.77
100%
-110
- C2 -
2ZYQ
1
HSAC_MYCTU
A:
[2-297]
-
S
I
R
S
L
G
Y
L
R
I
E
A
T
D
M
A
A
W
R
E
Y
G
L
K
V
L
G
M
V
E
G
K
G
A
P
E
G
A
L
Y
L
R
M
D
D
F
P
A
R
L
V
V
V
P
G
E
H
D
R
L
L
E
A
G
W
E
C
A
N
A
E
G
L
Q
E
I
R
N
R
L
D
L
E
G
T
P
Y
K
E
A
T
A
A
E
L
A
D
R
R
V
D
E
M
I
R
F
A
D
P
S
G
N
C
L
E
V
F
H
G
T
A
L
E
H
-
R
R
V
V
S
P
----
Y
-
G
--
H
R
F
V
T
G
E
Q
G
M
G
H
V
V
L
S
T
R
D
D
A
E
A
L
H
F
Y
R
D
V
L
G
F
R
L
R
D
--
S
M
R
L
P
P
Q
M
V
G
R
P
A
D
G
P
P
A
W
L
R
F
F
G
C
N
P
R
H
H
S
L
A
F
L
P
M
P
T
S
S
G
I
V
H
L
M
V
E
V
E
Q
A
D
D
V
G
L
C
L
D
R
A
L
R
R
K
V
P
M
S
A
T
L
G
R
H
V
N
D
L
M
L
S
F
Y
M
K
T
P
G
G
-
F
D
I
E
F
G
C
E
G
R
Q
V
D
D
R
D
W
I
A
R
E
S
T
A
V
S
L
W
G
H
D
F
T
V
G
---
2
PsiBlast_PDB
98.77
100%
-110
- C2 -
2ZYQ
1
HSAC_MYCTU
A:
[2-297]
-
S
I
R
S
L
G
Y
L
R
I
E
A
T
D
M
A
A
W
R
E
Y
G
L
K
V
L
G
M
V
E
G
K
G
A
P
E
G
A
L
Y
L
R
M
D
D
F
P
A
R
L
V
V
V
P
G
E
H
D
R
L
L
E
A
G
W
E
C
A
N
A
E
G
L
Q
E
I
R
N
R
L
D
L
E
G
T
P
Y
K
E
A
T
A
A
E
L
A
D
R
R
V
D
E
M
I
R
F
A
D
P
S
G
N
C
L
E
V
F
H
G
T
A
L
E
H
-
R
R
V
V
S
P
----
Y
-
G
--
H
R
F
V
T
G
E
Q
G
M
G
H
V
V
L
S
T
R
D
D
A
E
A
L
H
F
Y
R
D
V
L
G
F
R
L
R
D
--
S
M
R
L
P
P
Q
M
V
G
R
P
A
D
G
P
P
A
W
L
R
F
F
G
C
N
P
R
H
H
S
L
A
F
L
P
M
P
T
S
S
G
I
V
H
L
M
V
E
V
E
Q
A
D
D
V
G
L
C
L
D
R
A
L
R
R
K
V
P
M
S
A
T
L
G
R
H
V
N
D
L
M
L
S
F
Y
M
K
T
P
G
G
-
F
D
I
E
F
G
C
E
G
R
Q
V
D
D
R
D
W
I
A
R
E
S
T
A
V
S
L
W
G
H
D
F
T
V
G
---
22
PsiBlast_CBE
98.52
100%
-110
- C2 -
2ZI8
2
HSAC_MYCTU
B:
[1-298]
M
S
I
R
S
L
G
Y
L
R
I
E
A
T
D
M
A
A
W
R
E
Y
G
L
K
V
L
G
M
V
E
G
K
G
A
P
E
G
A
L
Y
L
R
M
D
D
F
P
A
R
L
V
V
V
P
G
E
H
D
R
L
L
E
A
G
W
E
C
A
N
A
E
G
L
Q
E
I
R
N
R
L
D
L
E
G
T
P
Y
K
E
A
T
A
A
E
L
A
D
R
R
V
D
E
M
I
R
F
A
D
P
S
G
N
C
L
E
V
F
H
G
T
A
L
E
H
-
R
R
V
V
S
P
----
Y
-
G
--
H
R
F
V
T
G
E
Q
G
M
G
H
V
V
L
S
T
R
D
D
A
E
A
L
H
F
Y
R
D
V
L
G
F
R
L
R
D
--
S
M
R
L
P
P
Q
M
V
G
R
P
A
D
G
P
P
A
W
L
R
F
F
G
C
N
P
R
H
H
S
L
A
F
L
P
M
P
T
S
S
G
I
V
H
L
M
V
E
V
E
Q
A
D
D
V
G
L
C
L
D
R
A
L
R
R
K
V
P
M
S
A
T
L
G
R
H
V
N
D
L
M
L
S
F
Y
M
K
T
P
G
G
-
F
D
I
E
F
G
C
E
G
R
Q
V
D
D
R
D
W
I
A
R
E
S
T
A
V
S
L
W
G
H
D
F
T
V
G
A
--
1
PsiBlast_PDB
97.82
100%
-112
- C2 -
2ZI8
2
HSAC_MYCTU
A:
[1-299]
M
S
I
R
S
L
G
Y
L
R
I
E
A
T
D
M
A
A
W
R
E
Y
G
L
K
V
L
G
M
V
E
G
K
G
A
P
E
G
A
L
Y
L
R
M
D
D
F
P
A
R
L
V
V
V
P
G
E
H
D
R
L
L
E
A
G
W
E
C
A
N
A
E
G
L
Q
E
I
R
N
R
L
D
L
E
G
T
P
Y
K
E
A
T
A
A
E
L
A
D
R
R
V
D
E
M
I
R
F
A
D
P
S
G
N
C
L
E
V
F
H
G
T
A
L
E
H
-
R
R
V
V
S
P
----
Y
-
G
--
H
R
F
V
T
G
E
Q
G
M
G
H
V
V
L
S
T
R
D
D
A
E
A
L
H
F
Y
R
D
V
L
G
F
R
L
R
D
--
S
M
R
L
P
P
Q
M
V
G
R
P
A
D
G
P
P
A
W
L
R
F
F
G
C
N
P
R
H
H
S
L
A
F
L
P
M
P
T
S
S
G
I
V
H
L
M
V
E
V
E
Q
A
D
D
V
G
L
C
L
D
R
A
L
R
R
K
V
P
M
S
A
T
L
G
R
H
V
N
D
L
M
L
S
F
Y
M
K
T
P
G
G
-
F
D
I
E
F
G
C
E
G
R
Q
V
D
D
R
D
W
I
A
R
E
S
T
A
V
S
L
W
G
H
D
F
T
V
G
A
R
-
6
PsiBlast_PDB
77.31
39%
-97
- C2 -
1LGT
4
BPHC_BURXL
A:
[1-284]
-
S
I
R
S
L
G
Y
M
G
F
A
V
S
D
V
A
A
W
R
S
F
L
T
Q
K
L
G
L
M
E
A
G
T
T
D
N
G
D
L
F
-
R
I
D
S
R
A
W
R
I
A
V
Q
Q
G
E
V
D
D
L
A
F
A
G
Y
E
V
A
D
A
A
G
L
A
Q
M
A
D
K
L
K
Q
A
G
I
A
V
T
T
G
D
A
S
L
A
R
R
R
G
V
T
G
L
I
T
F
A
D
P
F
G
L
P
L
E
I
Y
Y
G
A
S
E
V
F
-
E
K
P
F
L
P
----
G
-
A
AV
S
G
F
L
T
G
E
Q
G
L
G
H
F
V
R
C
V
P
D
S
D
K
A
L
A
F
Y
T
D
V
L
G
F
Q
L
S
D
VI
D
M
K
M
G
P
D
V
T
------
V
P
A
Y
--
F
L
H
C
N
E
R
H
H
T
L
A
I
A
A
F
P
L
P
K
R
I
H
H
F
M
L
E
V
A
S
L
D
D
V
G
F
A
F
D
R
V
D
A
D
G
L
-
I
T
S
T
L
G
R
H
T
N
D
H
M
V
S
F
Y
A
S
T
P
S
G
-
V
E
V
E
Y
G
W
S
A
R
T
V
-
D
R
S
W
V
V
V
R
H
D
S
P
S
M
W
G
H
--------
8
PsiBlast_PDB
76.83
39%
-94
- C2 -
1HAN
3
BPHC_BURXL
A:
[1-284]
-
S
I
R
S
L
G
Y
M
G
F
A
V
S
D
V
A
A
W
R
S
F
L
T
Q
K
L
G
L
M
E
A
G
T
T
D
N
G
D
L
F
-
R
I
D
S
R
A
W
R
I
A
V
Q
Q
G
E
V
D
D
L
A
F
A
G
Y
E
V
A
D
A
A
G
L
A
Q
M
A
D
K
L
K
Q
A
G
I
A
V
T
T
G
D
A
S
L
A
R
R
R
G
V
T
G
L
I
T
F
A
D
P
F
G
L
P
L
E
I
Y
Y
G
A
S
E
V
F
-
E
K
P
F
L
P
----
G
-
A
AV
S
G
F
L
T
G
E
Q
G
L
G
H
F
V
R
C
V
P
D
S
D
K
A
L
A
F
Y
T
D
V
L
G
F
Q
L
S
D
VI
D
M
K
M
G
P
D
V
T
------
V
P
A
Y
--
F
L
H
C
N
E
R
H
H
T
L
A
I
A
A
F
P
L
P
K
R
I
H
H
F
M
L
E
V
A
S
L
D
D
V
G
F
A
F
D
R
V
D
A
D
G
L
-
I
T
S
T
L
G
R
H
T
N
D
H
M
V
S
F
Y
A
S
T
P
S
G
-
V
E
V
E
Y
G
W
S
A
R
T
V
-
D
R
S
W
V
V
V
R
H
D
S
P
S
M
W
G
H
--------
7
PsiBlast_PDB
76.70
39%
-95
- C2 -
1LKD
5
BPHC_BURXL
A:
[1-284]
-
S
I
R
S
L
G
Y
M
G
F
A
V
S
D
V
A
A
W
R
S
F
L
T
Q
K
L
G
L
M
E
A
G
T
T
D
N
G
D
L
F
-
R
I
D
S
R
A
W
R
I
A
V
Q
Q
G
E
V
D
D
L
A
F
A
G
Y
E
V
A
D
A
A
G
L
A
Q
M
A
D
K
L
K
Q
A
G
I
A
V
T
T
G
D
A
S
L
A
R
R
R
G
V
T
G
L
I
T
F
A
D
P
F
G
L
P
L
E
I
Y
Y
G
A
S
E
V
F
-
E
K
P
F
L
P
----
G
-
A
AV
S
G
F
L
T
G
E
Q
G
L
G
H
F
V
R
C
V
P
D
S
D
K
A
L
A
F
Y
T
D
V
L
G
F
Q
L
S
D
VI
D
M
K
M
G
P
D
V
T
------
V
P
A
Y
--
F
L
H
C
N
E
R
H
H
T
L
A
I
A
A
F
P
L
P
K
R
I
H
H
F
M
L
E
V
A
S
L
D
D
V
G
F
A
F
D
R
V
D
A
D
G
L
-
I
T
S
T
L
G
R
H
T
N
D
H
M
V
S
F
Y
A
S
T
P
S
G
-
V
E
V
E
Y
G
W
S
A
R
T
V
-
D
R
S
W
V
V
V
R
H
D
S
P
S
M
W
G
H
--------
46
HHSearch
76.01
39%
-98
* C2 *
1LGT
4
BPHC_BURXL
A:
[1-287]
-
S
I
R
S
L
G
Y
M
G
F
A
V
S
D
V
A
A
W
R
S
F
L
T
Q
K
L
G
L
M
E
A
G
T
T
-
D
N
G
D
L
F
R
I
D
S
R
A
W
R
I
A
V
Q
Q
G
E
V
D
D
L
A
F
A
G
Y
E
V
A
D
A
A
G
L
A
Q
M
A
D
K
L
K
Q
A
G
I
A
V
T
T
G
D
A
S
L
A
R
R
R
G
V
T
G
L
I
T
F
A
D
P
F
G
L
P
L
E
I
Y
Y
G
A
S
E
V
F
E
K
P
F
L
P
G
----
A
A
V
--
S
G
F
L
T
G
E
Q
G
L
G
H
F
V
R
C
V
P
D
S
D
K
A
L
A
F
Y
T
D
V
L
G
F
Q
L
S
D
--
V
I
D
M
K
M
G
---
P
D
--
V
-
T
V
P
A
Y
F
L
H
C
N
E
R
H
H
T
L
A
I
A
A
F
P
L
P
K
R
I
H
H
F
M
L
E
V
A
S
L
D
D
V
G
F
A
F
D
R
V
D
A
D
G
L
I
T
S
T
-
L
G
R
H
T
N
D
H
M
V
S
F
Y
A
S
T
P
S
G
-
V
E
V
E
Y
G
W
S
A
R
T
V
D
-
R
S
W
V
V
V
R
H
D
S
P
S
M
W
G
H
K
S
V
-----
5
PsiBlast_PDB
75.81
39%
-96
- C2 -
1KNF
4
BPHC_BURXL
A:
[1-284]
-
S
I
R
S
L
G
Y
M
G
F
A
V
S
D
V
A
A
W
R
S
F
L
T
Q
K
L
G
L
M
E
A
G
T
T
D
N
G
D
L
F
-
R
I
D
S
R
A
W
R
I
A
V
Q
Q
G
E
V
D
D
L
A
F
A
G
Y
E
V
A
D
A
A
G
L
A
Q
M
A
D
K
L
K
Q
A
G
I
A
V
T
T
G
D
A
S
L
A
R
R
R
G
V
T
G
L
I
T
F
A
D
P
F
G
L
P
L
E
I
Y
Y
G
A
S
E
V
F
-
E
K
P
F
L
P
----
G
-
A
AV
S
G
F
L
T
G
E
Q
G
L
G
H
F
V
R
C
V
P
D
S
D
K
A
L
A
F
Y
T
D
V
L
G
F
Q
L
S
D
VI
D
M
K
M
G
P
D
V
T
------
V
P
A
Y
--
F
L
H
C
N
E
R
H
H
T
L
A
I
A
A
F
P
L
P
K
R
I
H
H
F
M
L
E
V
A
S
L
D
D
V
G
F
A
F
D
R
V
D
A
D
G
L
-
I
T
S
T
L
G
R
H
T
N
D
H
M
V
S
F
Y
A
S
T
P
S
G
-
V
E
V
E
Y
G
W
S
A
R
T
V
-
D
R
S
W
V
V
V
R
H
D
S
P
S
M
W
G
H
--------
3
PsiBlast_PDB
75.71
39%
-95
- C2 -
1KMY
3
BPHC_BURXL
A:
[1-284]
-
S
I
R
S
L
G
Y
M
G
F
A
V
S
D
V
A
A
W
R
S
F
L
T
Q
K
L
G
L
M
E
A
G
T
T
D
N
G
D
L
F
-
R
I
D
S
R
A
W
R
I
A
V
Q
Q
G
E
V
D
D
L
A
F
A
G
Y
E
V
A
D
A
A
G
L
A
Q
M
A
D
K
L
K
Q
A
G
I
A
V
T
T
G
D
A
S
L
A
R
R
R
G
V
T
G
L
I
T
F
A
D
P
F
G
L
P
L
E
I
Y
Y
G
A
S
E
V
F
-
E
K
P
F
L
P
----
G
-
A
AV
S
G
F
L
T
G
E
Q
G
L
G
H
F
V
R
C
V
P
D
S
D
K
A
L
A
F
Y
T
D
V
L
G
F
Q
L
S
D
VI
D
M
K
M
G
P
D
V
T
------
V
P
A
Y
--
F
L
H
C
N
E
R
H
H
T
L
A
I
A
A
F
P
L
P
K
R
I
H
H
F
M
L
E
V
A
S
L
D
D
V
G
F
A
F
D
R
V
D
A
D
G
L
-
I
T
S
T
L
G
R
H
T
N
D
H
M
V
S
F
Y
A
S
T
P
S
G
-
V
E
V
E
Y
G
W
S
A
R
T
V
-
D
R
S
W
V
V
V
R
H
D
S
P
S
M
W
G
H
--------
4
PsiBlast_PDB
75.43
39%
-95
- C2 -
1KND
4
BPHC_BURXL
A:
[1-284]
-
S
I
R
S
L
G
Y
M
G
F
A
V
S
D
V
A
A
W
R
S
F
L
T
Q
K
L
G
L
M
E
A
G
T
T
D
N
G
D
L
F
-
R
I
D
S
R
A
W
R
I
A
V
Q
Q
G
E
V
D
D
L
A
F
A
G
Y
E
V
A
D
A
A
G
L
A
Q
M
A
D
K
L
K
Q
A
G
I
A
V
T
T
G
D
A
S
L
A
R
R
R
G
V
T
G
L
I
T
F
A
D
P
F
G
L
P
L
E
I
Y
Y
G
A
S
E
V
F
-
E
K
P
F
L
P
----
G
-
A
AV
S
G
F
L
T
G
E
Q
G
L
G
H
F
V
R
C
V
P
D
S
D
K
A
L
A
F
Y
T
D
V
L
G
F
Q
L
S
D
VI
D
M
K
M
G
P
D
V
T
------
V
P
A
Y
--
F
L
H
C
N
E
R
H
H
T
L
A
I
A
A
F
P
L
P
K
R
I
H
H
F
M
L
E
V
A
S
L
D
D
V
G
F
A
F
D
R
V
D
A
D
G
L
-
I
T
S
T
L
G
R
H
T
N
D
H
M
V
S
F
Y
A
S
T
P
S
G
-
V
E
V
E
Y
G
W
S
A
R
T
V
-
D
R
S
W
V
V
V
R
H
D
S
P
S
M
W
G
H
--------
14
PsiBlast_PDB
73.95
36%
-87
- C2 -
1KW8
3
BPHC_PSES1
B:
[1-288]
-
S
I
E
R
L
G
Y
L
G
F
A
V
K
D
V
P
A
W
D
H
F
L
T
K
S
V
G
L
M
A
A
G
S
A
G
D
A
A
L
Y
-
R
A
D
Q
R
A
W
R
I
A
V
Q
P
G
E
L
D
D
L
A
Y
A
G
L
E
V
D
D
A
A
A
L
E
R
M
A
D
K
L
R
Q
A
G
V
A
F
T
R
G
D
E
A
L
M
Q
Q
R
K
V
M
G
L
L
C
L
Q
D
P
F
G
L
P
L
E
I
Y
Y
G
P
A
E
I
F
-
H
E
P
F
L
P
----
S
-
A
PV
S
G
F
V
T
G
D
Q
G
I
G
H
F
V
R
C
V
P
D
T
A
K
A
M
A
F
Y
T
E
V
L
G
F
V
L
S
D
--
I
I
D
I
--
Q
M
--
G
P
E
T
S
V
P
A
--
H
F
L
H
C
N
G
R
H
H
T
I
A
L
A
A
F
P
I
P
K
R
I
H
H
F
M
L
Q
A
N
T
I
D
D
V
G
Y
A
F
D
R
-
L
D
A
A
G
R
I
T
S
L
L
G
R
H
T
N
D
Q
T
L
S
F
Y
A
D
T
P
S
P
M
I
E
V
E
F
G
W
G
P
R
T
V
D
S
S
W
T
V
A
R
H
S
R
-
T
A
M
W
G
H
K
S
V
-----
9
PsiBlast_PDB
73.75
36%
-87
- C2 -
1EIQ
1
BPHC_PSES1
A:
[1-289]
-
S
I
E
R
L
G
Y
L
G
F
A
V
K
D
V
P
A
W
D
H
F
L
T
K
S
V
G
L
M
A
A
G
S
A
G
D
A
A
L
Y
-
R
A
D
Q
R
A
W
R
I
A
V
Q
P
G
E
L
D
D
L
A
Y
A
G
L
E
V
D
D
A
A
A
L
E
R
M
A
D
K
L
R
Q
A
G
V
A
F
T
R
G
D
E
A
L
M
Q
Q
R
K
V
M
G
L
L
C
L
Q
D
P
F
G
L
P
L
E
I
Y
Y
G
P
A
E
I
F
-
H
E
P
F
L
P
----
S
-
A
PV
S
G
F
V
T
G
D
Q
G
I
G
H
F
V
R
C
V
P
D
T
A
K
A
M
A
F
Y
T
E
V
L
G
F
V
L
S
D
--
I
I
D
I
--
Q
M
--
G
P
E
T
S
V
P
A
--
H
F
L
H
C
N
G
R
H
H
T
I
A
L
A
A
F
P
I
P
K
R
I
H
H
F
M
L
Q
A
N
T
I
D
D
V
G
Y
A
F
D
R
-
L
D
A
A
G
R
I
T
S
L
L
G
R
H
T
N
D
Q
T
L
S
F
Y
A
D
T
P
S
P
M
I
E
V
E
F
G
W
G
P
R
T
V
D
S
S
W
T
V
A
R
H
S
R
-
T
A
M
W
G
H
K
S
V
R
----
15
PsiBlast_PDB
73.65
36%
-89
- C2 -
1KW9
2
BPHC_PSES1
B:
[1-288]
-
S
I
E
R
L
G
Y
L
G
F
A
V
K
D
V
P
A
W
D
H
F
L
T
K
S
V
G
L
M
A
A
G
S
A
G
D
A
A
L
Y
-
R
A
D
Q
R
A
W
R
I
A
V
Q
P
G
E
L
D
D
L
A
Y
A
G
L
E
V
D
D
A
A
A
L
E
R
M
A
D
K
L
R
Q
A
G
V
A
F
T
R
G
D
E
A
L
M
Q
Q
R
K
V
M
G
L
L
C
L
Q
D
P
F
G
L
P
L
E
I
Y
Y
G
P
A
E
I
F
-
H
E
P
F
L
P
----
S
-
A
PV
S
G
F
V
T
G
D
Q
G
I
G
H
F
V
R
C
V
P
D
T
A
K
A
M
A
F
Y
T
E
V
L
G
F
V
L
S
D
--
I
I
D
I
--
Q
M
--
G
P
E
T
S
V
P
A
--
H
F
L
H
C
N
G
R
H
H
T
I
A
L
A
A
F
P
I
P
K
R
I
H
H
F
M
L
Q
A
N
T
I
D
D
V
G
Y
A
F
D
R
-
L
D
A
A
G
R
I
T
S
L
L
G
R
H
T
N
D
Q
T
L
S
F
Y
A
D
T
P
S
P
M
I
E
V
E
F
G
W
G
P
R
T
V
D
S
S
W
T
V
A
R
H
S
R
-
T
A
M
W
G
H
K
S
V
-----
26
PsiBlast_CBE
73.44
32%
-98
- C2 -
2EI2
4
NAHC_PSEU8
A:
[6-277]
-
A
V
I
E
L
G
Y
M
G
I
S
V
K
D
P
D
A
W
K
S
F
A
T
D
M
L
G
L
Q
V
L
D
E
G
E
K
D
R
F
Y
L
R
M
D
Y
W
H
H
R
I
V
V
H
H
N
G
Q
D
D
L
E
Y
L
G
W
R
V
A
G
K
P
E
F
E
A
L
G
Q
K
L
I
D
A
G
Y
K
I
R
I
C
D
K
V
E
A
Q
E
R
M
V
L
G
L
M
K
T
E
D
P
G
G
N
P
T
E
I
F
W
G
P
R
I
D
M
-
S
N
P
F
H
P
GRPL
H
-
G
---
K
F
V
T
G
D
Q
G
L
G
H
C
I
V
R
Q
T
D
V
A
E
A
H
K
F
Y
-
S
L
L
G
F
R
G
D
V
--
E
Y
R
I
P
L
------
P
N
G
M
T
A
E
L
S
F
M
H
C
N
A
R
D
H
S
I
A
F
G
A
M
P
A
A
K
R
L
N
H
L
M
L
E
Y
T
H
M
E
D
L
G
Y
T
H
Q
Q
F
V
K
N
E
I
D
I
A
L
Q
L
G
I
H
A
N
D
K
A
L
T
F
Y
G
A
T
P
S
G
-
W
L
I
E
P
G
W
R
G
A
T
A
I
D
E
-----------------------
18
PsiBlast_PDB
73.36
36%
-88
- C2 -
1KWC
1
BPHC_PSES1
B:
[1-288]
-
S
I
E
R
L
G
Y
L
G
F
A
V
K
D
V
P
A
W
D
H
F
L
T
K
S
V
G
L
M
A
A
G
S
A
G
D
A
A
L
Y
-
R
A
D
Q
R
A
W
R
I
A
V
Q
P
G
E
L
D
D
L
A
Y
A
G
L
E
V
D
D
A
A
A
L
E
R
M
A
D
K
L
R
Q
A
G
V
A
F
T
R
G
D
E
A
L
M
Q
Q
R
K
V
M
G
L
L
C
L
Q
D
P
F
G
L
P
L
E
I
Y
Y
G
P
A
E
I
F
-
H
E
P
F
L
P
----
S
-
A
PV
S
G
F
V
T
G
D
Q
G
I
G
A
F
V
R
C
V
P
D
T
A
K
A
M
A
F
Y
T
E
V
L
G
F
V
L
S
D
--
I
I
D
I
--
Q
M
--
G
P
E
T
S
V
P
A
--
H
F
L
H
C
N
G
R
H
H
T
I
A
L
A
A
F
P
I
P
K
R
I
H
H
F
M
L
Q
A
N
T
I
D
D
V
G
Y
A
F
D
R
-
L
D
A
A
G
R
I
T
S
L
L
G
R
H
T
N
D
Q
T
L
S
F
Y
A
D
T
P
S
P
M
I
E
V
E
F
G
W
G
P
R
T
V
D
S
S
W
T
V
A
R
H
S
R
-
T
A
M
W
G
H
K
S
V
-----
30
PsiBlast_CBE
73.35
32%
-98
- C2 -
2EHZ
9
NAHC_PSEU8
A:
[6-277]
-
A
V
I
E
L
G
Y
M
G
I
S
V
K
D
P
D
A
W
K
S
F
A
T
D
M
L
G
L
Q
V
L
D
E
G
E
K
D
R
F
Y
L
R
M
D
Y
W
H
H
R
I
V
V
H
H
N
G
Q
D
D
L
E
Y
L
G
W
R
V
A
G
K
P
E
F
E
A
L
G
Q
K
L
I
D
A
G
Y
K
I
R
I
C
D
K
V
E
A
Q
E
R
M
V
L
G
L
M
K
T
E
D
P
G
G
N
P
T
E
I
F
W
G
P
R
I
D
M
-
S
N
P
F
H
P
GRPL
H
-
G
---
K
F
V
T
G
D
Q
G
L
G
H
C
I
V
R
Q
T
D
V
A
E
A
H
K
F
Y
-
S
L
L
G
F
R
G
D
V
--
E
Y
R
I
P
L
------
P
N
G
M
T
A
E
L
S
F
M
H
C
N
A
R
D
H
S
I
A
F
G
A
M
P
A
A
K
R
L
N
H
L
M
L
E
Y
T
H
M
E
D
L
G
Y
T
H
Q
Q
F
V
K
N
E
I
D
I
A
L
Q
L
G
I
H
A
N
D
K
A
L
T
F
Y
G
A
T
P
S
G
-
W
L
I
E
P
G
W
R
G
A
T
A
I
D
E
-----------------------
11
PsiBlast_PDB
73.30
36%
-88
- C2 -
1EIL
2
BPHC_PSES1
A:
[1-289]
-
S
I
E
R
L
G
Y
L
G
F
A
V
K
D
V
P
A
W
D
H
F
L
T
K
S
V
G
L
M
A
A
G
S
A
G
D
A
A
L
Y
-
R
A
D
Q
R
A
W
R
I
A
V
Q
P
G
E
L
D
D
L
A
Y
A
G
L
E
V
D
D
A
A
A
L
E
R
M
A
D
K
L
R
Q
A
G
V
A
F
T
R
G
D
E
A
L
M
Q
Q
R
K
V
M
G
L
L
C
L
Q
D
P
F
G
L
P
L
E
I
Y
Y
G
P
A
E
I
F
-
H
E
P
F
L
P
----
S
-
A
PV
S
G
F
V
T
G
D
Q
G
I
G
H
F
V
R
C
V
P
D
T
A
K
A
M
A
F
Y
T
E
V
L
G
F
V
L
S
D
--
I
I
D
I
--
Q
M
--
G
P
E
T
S
V
P
A
--
H
F
L
H
C
N
G
R
H
H
T
I
A
L
A
A
F
P
I
P
K
R
I
H
H
F
M
L
Q
A
N
T
I
D
D
V
G
Y
A
F
D
R
-
L
D
A
A
G
R
I
T
S
L
L
G
R
H
T
N
D
Q
T
L
S
F
Y
A
D
T
P
S
P
M
I
E
V
E
F
G
W
G
P
R
T
V
D
S
S
W
T
V
A
R
H
S
R
-
T
A
M
W
G
H
K
S
V
R
----
27
PsiBlast_CBE
73.27
32%
-98
- C2 -
2EI3
6
NAHC_PSEU8
A:
[6-277]
-
A
V
I
E
L
G
Y
M
G
I
S
V
K
D
P
D
A
W
K
S
F
A
T
D
M
L
G
L
Q
V
L
D
E
G
E
K
D
R
F
Y
L
R
M
D
Y
W
H
H
R
I
V
V
H
H
N
G
Q
D
D
L
E
Y
L
G
W
R
V
A
G
K
P
E
F
E
A
L
G
Q
K
L
I
D
A
G
Y
K
I
R
I
C
D
K
V
E
A
Q
E
R
M
V
L
G
L
M
K
T
E
D
P
G
G
N
P
T
E
I
F
W
G
P
R
I
D
M
-
S
N
P
F
H
P
GRPL
H
-
G
---
K
F
V
T
G
D
Q
G
L
G
H
C
I
V
R
Q
T
D
V
A
E
A
H
K
F
Y
-
S
L
L
G
F
R
G
D
V
--
E
Y
R
I
P
L
------
P
N
G
M
T
A
E
L
S
F
M
H
C
N
A
R
D
H
S
I
A
F
G
A
M
P
A
A
K
R
L
N
H
L
M
L
E
Y
T
H
M
E
D
L
G
Y
T
H
Q
Q
F
V
K
N
E
I
D
I
A
L
Q
L
G
I
H
A
N
D
K
A
L
T
F
Y
G
A
T
P
S
G
-
W
L
I
E
P
G
W
R
G
A
T
A
I
D
E
-----------------------
10
PsiBlast_PDB
73.16
36%
-88
- C2 -
1EIR
2
BPHC_PSES1
A:
[1-289]
-
S
I
E
R
L
G
Y
L
G
F
A
V
K
D
V
P
A
W
D
H
F
L
T
K
S
V
G
L
M
A
A
G
S
A
G
D
A
A
L
Y
-
R
A
D
Q
R
A
W
R
I
A
V
Q
P
G
E
L
D
D
L
A
Y
A
G
L
E
V
D
D
A
A
A
L
E
R
M
A
D
K
L
R
Q
A
G
V
A
F
T
R
G
D
E
A
L
M
Q
Q
R
K
V
M
G
L
L
C
L
Q
D
P
F
G
L
P
L
E
I
Y
Y
G
P
A
E
I
F
-
H
E
P
F
L
P
----
S
-
A
PV
S
G
F
V
T
G
D
Q
G
I
G
H
F
V
R
C
V
P
D
T
A
K
A
M
A
F
Y
T
E
V
L
G
F
V
L
S
D
--
I
I
D
I
--
Q
M
--
G
P
E
T
S
V
P
A
--
H
F
L
H
C
N
G
R
H
H
T
I
A
L
A
A
F
P
I
P
K
R
I
H
H
F
M
L
Q
A
N
T
I
D
D
V
G
Y
A
F
D
R
-
L
D
A
A
G
R
I
T
S
L
L
G
R
H
T
N
D
Q
T
L
S
F
Y
A
D
T
P
S
P
M
I
E
V
E
F
G
W
G
P
R
T
V
D
S
S
W
T
V
A
R
H
S
R
-
T
A
M
W
G
H
K
S
V
R
----
13
PsiBlast_PDB
72.72
36%
-86
- C2 -
1KW6
4
BPHC_PSES1
B:
[1-288]
-
S
I
E
R
L
G
Y
L
G
F
A
V
K
D
V
P
A
W
D
H
F
L
T
K
S
V
G
L
M
A
A
G
S
A
G
D
A
A
L
Y
-
R
A
D
Q
R
A
W
R
I
A
V
Q
P
G
E
L
D
D
L
A
Y
A
G
L
E
V
D
D
A
A
A
L
E
R
M
A
D
K
L
R
Q
A
G
V
A
F
T
R
G
D
E
A
L
M
Q
Q
R
K
V
M
G
L
L
C
L
Q
D
P
F
G
L
P
L
E
I
Y
Y
G
P
A
E
I
F
-
H
E
P
F
L
P
----
S
-
A
PV
S
G
F
V
T
G
D
Q
G
I
G
H
F
V
R
C
V
P
D
T
A
K
A
M
A
F
Y
T
E
V
L
G
F
V
L
S
D
--
I
I
D
I
--
Q
M
--
G
P
E
T
S
V
P
A
--
H
F
L
H
C
N
G
R
H
H
T
I
A
L
A
A
F
P
I
P
K
R
I
H
H
F
M
L
Q
A
N
T
I
D
D
V
G
Y
A
F
D
R
-
L
D
A
A
G
R
I
T
S
L
L
G
R
H
T
N
D
Q
T
L
S
F
Y
A
D
T
P
S
P
M
I
E
V
E
F
G
W
G
P
R
T
V
D
S
S
W
T
V
A
R
H
S
R
-
T
A
M
W
G
H
K
S
V
-----
28
PsiBlast_CBE
72.46
32%
-99
- C2 -
2EI1
4
NAHC_PSEU8
A:
[6-277]
-
A
V
I
E
L
G
Y
M
G
I
S
V
K
D
P
D
A
W
K
S
F
A
T
D
M
L
G
L
Q
V
L
D
E
G
E
K
D
R
F
Y
L
R
M
D
Y
W
H
H
R
I
V
V
H
H
N
G
Q
D
D
L
E
Y
L
G
W
R
V
A
G
K
P
E
F
E
A
L
G
Q
K
L
I
D
A
G
Y
K
I
R
I
C
D
K
V
E
A
Q
E
R
M
V
L
G
L
M
K
T
E
D
P
G
G
N
P
T
E
I
F
W
G
P
R
I
D
M
-
S
N
P
F
H
P
GRPL
H
-
G
---
K
F
V
T
G
D
Q
G
L
G
H
C
I
V
R
Q
T
D
V
A
E
A
H
K
F
Y
-
S
L
L
G
F
R
G
D
V
--
E
Y
R
I
P
-----------
T
A
E
L
S
F
M
H
C
N
A
R
D
H
S
I
A
F
G
A
M
P
A
A
K
R
L
N
H
L
M
L
E
Y
T
H
M
E
D
L
G
Y
T
H
Q
Q
F
V
K
N
E
I
D
I
A
L
Q
L
G
I
H
A
N
D
K
A
L
T
F
Y
G
A
T
P
S
G
-
W
L
I
E
P
G
W
R
G
A
T
A
I
D
E
-----------------------
29
PsiBlast_CBE
71.87
32%
-98
- C2 -
2EI0
6
NAHC_PSEU8
A:
[6-277]
-
A
V
I
E
L
G
Y
M
G
I
S
V
K
D
P
D
A
W
K
S
F
A
T
D
M
L
G
L
Q
V
L
D
E
G
E
K
D
R
F
Y
L
R
M
D
Y
W
H
H
R
I
V
V
H
H
N
G
Q
D
D
L
E
Y
L
G
W
R
V
A
G
K
P
E
F
E
A
L
G
Q
K
L
I
D
A
G
Y
K
I
R
I
C
D
K
V
E
A
Q
E
R
M
V
L
G
L
M
K
T
E
D
P
G
G
N
P
T
E
I
F
W
G
P
R
I
D
M
-
S
N
P
F
H
P
GRPL
H
-
G
---
K
F
V
T
G
D
Q
G
L
G
H
C
I
V
R
Q
T
D
V
A
E
A
H
K
F
Y
-
S
L
L
G
F
R
G
D
V
--
E
Y
R
I
P
-----------
T
A
E
L
S
F
M
H
C
N
A
R
D
H
S
I
A
F
G
A
M
P
A
A
K
R
L
N
H
L
M
L
E
Y
T
H
M
E
D
L
G
Y
T
H
Q
Q
F
V
K
N
E
I
D
I
A
L
Q
L
G
I
H
A
N
D
K
A
L
T
F
Y
G
A
T
P
S
G
-
W
L
I
E
P
G
W
R
G
A
T
A
I
D
E
-----------------------