@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3834c: (2016-05-23 )
MIDLKLLRENPDAVRRSQLSRGEDPALVDALLTADAARRAVISTADSLRAEQKAASKSVGGASPEERPPLLRRAKELAEQVKAAEADEVEAEAAFTAAHLAISNVIVDGVPAGGEDDYAVLDVVGEPSYLENPKDHLELGESLGLIDMQRGAKVSGSRFYFLTGRGALLQLGLLQLALKLAVDNGFVPTIPPVLVRPEVMVGTGFLGAHAEEVYRVEGDGLYLVGTSEVPLAGYHSGEILDLSRGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQFDKVEGFVYCTPADAEHEHERLLGWQRQMLARIEVPYRVIDVAAGDLGSSAARKFDCEAWIPTQGAYRELTSTSNCTTFQARRLATRYRDASGKPQIAATLNGTLATTRWLVAILENHQRPDGSVRVPDALVPFVGVEVLEPVA
Atome Classification :
(33 SA)
-----------------------------------------------------------------------------------------------........----.----10---...--......20..--.-.--...--.30.....----------...40..--------......---50........60.--..--.--------.----------.-.------------------------.---------------------------.-------------------------------70...-----------------------....-.80.--.......90........100.......110.-.-..--.-.--.--120....--------...--------------------130-------------..-.-.------------....140.......150.-.......160.......170.......180.......190.......200....-...210.....----..---.220---------.........230..---.....240.--........250.......260.......270.......280.....--.--.290-...--.....300.......310.......320.......330.......340.......350.......360---.------...-.--.-.370.......-380-........390.......400.......-410...--......-------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------M
I
D
L
K
LLR----E----N----
P
D
A
--
V
R
R
S
Q
LSRGE--
D
-
P
--
A
L
V
--
D
A
L
L
T
A
D
A
----------
A
R
R
A
V
I
S
--------
T
A
D
S
L
R
---
A
E
Q
K
AASKSVG-G--AS--P--------E----------E-R------------------------
P
---------------------------
P
-------------------------------
L
L
R
R
A
-----------------------
K
E
L
A
-
E
Q
V
K--AAEA
D
E
V
E
A
E
A
A
F
T
A
A
H
L
A
I
S
N
V
IVDGVPAG-G-ED--
D
-
Y
--
A
--
V
L
DVVGE--------PSY--------------------L-E-------------N
P
-
K
-
D
------------
H
L
E
L
G
E
SLGL
I
D
M
QRG-A-KVSG
S
R
F
Y
F
LTG
R
G
A
L
L
Q
L
G
L
L
Q
L
A
L
K
L
AVDNGFVPTIPP
V
L
VRP
E
V
M
V
GTGFL-GA
H
A
-
E
E
V
Y
R
V----EG---D
G
-----------
L
Y
L
V
GTSEVPLAGY---HS
G
E
I
L
--D--LSRGPLRYA
G
W
S
S
C
F
R
R
EAGSHGKDT
R
G
I
I
R
V
H
Q
FDKV
E
G
F
V
Y
CTP--A--DA
E
--
H
E
H
--
E
R
L
L
G
W
Q
R
Q
M
L
A
R
IEV
P
Y
R
V
I
D
VAAGDLG
S
S
A
A
RKFDC
E
A
WIPTQG
A
Y
R
E
LTSTSNC
T
T
F
Q
A
R
R
L
A
T
R
---Y------RDA-S--G-K
P
Q
I
A
A
T
LNG
T
-
L
-
A
-
T
T
R
W
L
V
A
I
L
E
NHQRPDG
S
V
RVP
D
A
LVPF-V--
G
V
E
--
V
LEPVA-------------
47
HHSearch
93.98
42%
-75
- C3 -
2DQ0
5
SYS_PYRHO
A:
[1-447]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
----
P
E
L
--
V
K
N
D
L
I
K
R
G
E
--
L
-
E
K
V
K
W
V
--
D
E
I
L
K
L
D
T
----------
E
W
R
T
K
L
K
--------
E
I
N
R
L
R
---
H
E
R
N
K
I
A
V
E
I
G
-
K
--
R
R
KK
G
--------
E
----------
P
-
V
------------------------
D
---------------------------
E
-------------------------------
L
L
A
K
S
-----------------------
R
E
I
V
-
K
R
I
G
--
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
-
K
-
D
E
--
N
D
N
--
V
--
P
I
R
F
W
G
K
--------
A
R
V
WKGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
-------------
K
P
-
K
-
L
------------
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
-
E
D
F
E
-
D
V
I
Y
K
V
----
E
D
---
E
D
-----------
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
---
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
--
E
W
H
--
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
---
F
------
R
D
R
-
T
--
D
E
K
P
R
Y
V
H
T
L
N
S
T
-
A
I
A
-
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
-
T
--
G
F
K
--
E
I
V
P
V
E
-------------
4
PsiBlast_PDB
92.45
42%
-82
- C3 -
2DQ3
1
SYS_AQUAE
A:
[2-424]
------------------------------------------------------------------------------------------------
I
D
I
N
L
I
R
----
E
----
K
----
P
D
Y
--
V
K
E
R
L
A
T
R
D
K
--
E
L
V
--
S
L
V
--
D
K
V
L
E
L
D
K
----------
R
R
R
E
I
I
K
--------
R
L
E
A
L
R
---
S
E
R
N
K
L
S
K
E
I
G
-
K
--
L
K
--
R
--------
E
GK--------
D
-
T
------------------------
T
---------------------------
E
-------------------------------
I
Q
N
R
V
-----------------------
K
E
L
K
-
E
E
I
D
--
R
L
E
E
E
L
R
K
V
E
E
E
L
K
N
T
L
L
W
I
P
N
L
P
H
P
S
V
P
V
G
E
D
-
E
K
--
D
-
N
--
V
--
E
V
R
R
W
G
E
--------
P
R
K
--------------------
F
-
D
F------------
E
P
-
K
-
P
------------
H
W
E
I
G
E
R
L
G
I
L
D
F
K
R
G
-
A
-
K
L
S
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
K
K
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
-
P
K
F
E
-
E
D
L
Y
K
C
----
E
R
---
D
N
-----------
L
Y
L
I
P
T
A
E
V
P
L
T
N
L
---
Y
R
E
E
I
L
--
K
--
E
E
N
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
L
V
K
I
V
H
P
--
D
--
T
S
Y
--
D
E
L
--
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
---
F
------
K
D
S
K
T
--
G
-
K
N
R
F
V
H
T
L
N
G
S
G
L
-
A
-
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
-
V
--
G
T
D
--
V
I
R
P
---------------
45
HHSearch
92.27
42%
-81
- C3 -
2DQ3
1
SYS_AQUAE
A:
[1-425]
-----------------------------------------------------------------------------------------------
M
I
D
I
N
L
I
R
----
E
----
K
----
P
D
Y
--
V
K
E
R
L
A
T
R
D
K
--
E
-
L
V
-
S
L
V
--
D
K
V
L
E
L
D
K
----------
R
R
R
E
I
I
K
--------
R
L
E
A
L
R
---
S
E
R
N
K
L
S
K
E
I
G
-
K
--
L
K
RE
G
--------
K
----------
D
-
T
------------------------
T
---------------------------
E
-------------------------------
I
Q
N
R
V
-----------------------
K
E
L
K
-
E
E
I
D
--
R
L
E
E
E
L
R
K
V
E
E
E
L
K
N
T
L
L
W
I
P
N
L
P
H
P
S
V
P
V
G
-
E
-
D
E
--
K
D
N
--
V
--
E
V
R
R
W
G
E
--------
P
R
K
--------------------
F
D
F
-------------
E
P
-
K
-
P
------------
H
W
E
I
G
E
R
L
G
I
L
D
F
K
R
G
-
A
-
K
L
S
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
K
K
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
-
P
K
F
E
-
E
D
L
Y
K
C
----
E
R
---
D
N
-----------
L
Y
L
I
P
T
A
E
V
P
L
T
N
L
---
Y
R
E
E
I
L
--
K
--
E
E
N
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
L
V
K
I
V
H
P
--
D
--
T
S
Y
--
D
E
L
--
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
---
F
------
K
D
S
-
K
T-
G
-
K
N
R
F
V
H
T
L
N
G
S
-
G
L
A
-
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
-
V
--
G
T
D
--
V
I
R
P
E
--------------
1
PsiBlast_PDB
91.82
39%
-77
- C3 -
2DQ0
5
SYS_PYRHO
A:
[1-446]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
----
P
E
L
--
V
K
N
D
L
I
K
R
G
E
LE
K
-
V
--
K
W
V
--
D
E
I
L
K
L
D
T
----------
E
W
R
T
K
L
K
--------
E
I
N
R
L
R
---
H
E
R
N
K
I
A
V
E
I
G
-
K
--
R
R
--
K
--------
K
----------
G
-
E
------------------------
P
V
D
-------------------------
E
-------------------------------
L
L
A
K
S
-----------------------
R
E
I
V
-
K
R
I
G
--
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
-
K
D
E
N
--
D
-
N
--
V
--
P
I
R
F
W
G
K
ARVWKGH
L
E
R
F
--------------------
L
-
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
-
K
-
L
------------
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
-
E
D
F
E
-
D
V
I
Y
K
V
----
E
D
---
E
D
-----------
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
---
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
--
E
W
H
--
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
---
F
------
R
D
R
-
T
--
D
E
K
P
R
Y
V
H
T
L
N
S
T
A
I
-
A
-
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
-
T
--
G
F
K
--
E
I
V
P
V
--------------
22
PsiBlast_CBE
90.31
39%
-79
- C3 -
2DQ0
4
SYS_PYRHO
B:
[1-446]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
----
P
E
L
--
V
K
N
D
L
I
K
R
G
E
LE
K
-
V
--
K
W
V
--
D
E
I
L
K
L
D
T
----------
E
W
R
T
K
L
K
--------
E
I
N
R
L
R
---
H
E
R
N
K
I
A
V
E
I
G
-
K
--
R
R
--
K
--------
K
----------
G
-
E
------------------------
P
VD-------------------------
E
-------------------------------
L
L
A
K
S
-----------------------
R
E
I
V
-
K
R
I
G
--
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
-
K
D
E
N
--
D
-
N
--
V
--
P
I
R
F
W
G
K
ARVWKGHL
E
R
F
--------------------
L
-
E
QSQGKMEYEILEW
K
P
-
K
-
L
------------
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
-
E
D
F
E
-
D
V
I
Y
K
V
----
E
D
---
E
D
-----------
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
---
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
--
E
W
H
--
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
---
F
------
R
D
R
-
T
--
D
E
K
P
R
Y
V
H
T
L
N
S
T
A
I
-
A
-
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
-
T
--
G
F
K
--
E
I
V
P
V
--------------
2
PsiBlast_PDB
89.90
39%
-76
- C3 -
2ZR2
5
SYS_PYRHO
A:
[1-446]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
----
P
E
L
--
V
K
N
D
L
I
K
R
G
E
LE
K
-
V
--
K
W
V
--
D
E
I
L
K
L
D
T
----------
E
W
R
T
K
L
K
--------
E
I
N
R
L
R
---
H
E
R
N
K
I
A
V
E
I
G
-
K
--
R
R
--
K
--------
K
----------
G
-
E
------------------------
P
V
D
-------------------------
E
-------------------------------
L
L
A
K
S
-----------------------
R
E
I
V
-
K
R
I
G
--
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
-
K
D
E
N
--
D
-
N
--
V
--
P
I
R
F
W
G
K
A
R
V
W
KGH
L
E
R
F
--------------------
L
-
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
-
K
-
L
------------
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
-
E
D
F
E
-
D
V
I
Y
K
V
----
E
D
---
E
D
-----------
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
---
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
--
E
W
H
--
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
---
F
------
R
D
R
-
T
--
D
E
K
P
R
Y
V
H
T
L
N
S
T
A
I
-
A
-
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
-
T
--
G
F
K
--
E
I
V
P
V
--------------
21
PsiBlast_CBE
89.45
39%
-76
- C3 -
2ZR2
4
SYS_PYRHO
B:
[1-446]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
----
P
E
L
--
V
K
N
D
L
I
K
R
G
E
LE
K
-
V
--
K
W
V
--
D
E
I
L
K
L
D
T
----------
E
W
R
T
K
L
K
--------
E
I
N
R
L
R
---
H
E
R
N
K
I
A
V
E
I
G
-
K
--
R
R
--
K
--------
K
----------
G
-
E
------------------------
P
VD-------------------------
E
-------------------------------
L
L
A
K
S
-----------------------
R
E
I
V
-
K
R
I
G
--
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
-
K
D
E
N
--
D
-
N
--
V
--
P
I
R
F
W
G
K
ARVWKGHL
E
R
F
--------------------
L
-
E
QSQGKMEYEILEW
K
P
-
K
-
L
------------
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
-
E
D
F
E
-
D
V
I
Y
K
V
----
E
D
---
E
D
-----------
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
---
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
--
E
W
H
--
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
---
F
------
R
D
R
-
T
--
D
E
K
P
R
Y
V
H
T
L
N
S
T
A
I
-
A
-
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
-
T
--
G
F
K
--
E
I
V
P
V
--------------
3
PsiBlast_PDB
89.06
39%
-74
- C3 -
2ZR3
-
SYS_PYRHO
A:
[1-446]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
----
P
E
L
--
V
K
N
D
L
I
K
R
G
E
LE
K
-
V
--
K
W
V
--
D
E
I
L
K
L
D
T
----------
E
W
R
T
K
L
K
--------
E
I
N
R
L
R
---
H
E
R
N
K
I
A
V
E
I
G
-
K
--
R
R
--
K
--------
K
----------
G
-
E
------------------------
P
V
D
-------------------------
E
-------------------------------
L
L
A
K
S
-----------------------
R
E
I
V
-
K
R
I
G
--
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
-
K
D
E
N
--
D
-
N
--
V
--
P
I
R
F
W
G
K
ARVWKGH
L
E
R
F
--------------------
L
-
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
-
K
-
L
------------
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
-
E
D
F
E
-
D
V
I
Y
K
V
----
E
D
---
E
D
-----------
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
---
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
--
E
W
H
--
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
---
F
------
R
D
R
-
T
--
D
E
K
P
R
Y
V
H
T
L
N
S
T
A
I
-
A
-
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
-
T
--
G
F
K
--
E
I
V
P
V
--------------
44
HHSearch
88.79
41%
-79
- C3 -
1SES
1
SYS_THET2
A:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
----
Q
----
E
----
P
E
V
--
F
H
R
A
I
R
E
K
G
V
--
A
-
L
---
D
L
--
E
A
L
L
A
L
D
R
----------
E
V
Q
E
L
K
K
--------
R
L
Q
E
V
Q
---
T
E
R
N
Q
V
A
K
R
V
P
-
K
--
A
P
--
P
--------
E
----------
E
-
K
------------------------
E
---------------------------
A
-------------------------------
L
I
A
R
G
-----------------------
K
A
L
G
-
E
E
A
K
--
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
-
E
E
--
A
-
N
--
R
--
E
I
K
R
V
G
G
--------
P
P
E
--------------------
F
S
F
-------------
P
P
-
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
-
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
-----------
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
---
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
--
R
A
F
--
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
---
Y
------
R
D
P
-
E
--
G
-
R
V
R
Y
A
Y
T
L
N
N
T
-
A
L
A
-
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
-
M
--
G
K
E
--
V
L
E
P
---------------
5
PsiBlast_PDB
87.68
40%
-76
- C3 -
1SRY
-
SYS_THET2
A:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
----
Q
----
E
----
P
E
V
--
F
H
R
A
I
R
E
K
G
---------
V
A
--
L
D
L
E
A
L
L
A
----------
L
D
R
E
V
Q
E
--------
L
K
K
R
L
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
-
K
--
A
P
--
P
--------
E
----------
E
-
K
------------------------
E
---------------------------
A
-------------------------------
L
I
A
R
G
-----------------------
K
A
L
G
-
E
E
A
K
--
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
-
E
E
A-
N
-
R
--
E
--
I
K
R
V
G
G
P
--------
P
E
F
--------------------
S
-
F
-------------
P
P
-
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
-
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
-----------
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
---
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
--
S
L
E
A
S
D
--
R
A
F
--
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
---
Y
------
R
D
P
-
E
--
G
-
R
V
R
Y
A
Y
T
L
N
N
T
A
L
-
A
-
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
-
M
--
G
K
E
--
V
L
E
P
---------------
7
PsiBlast_PDB
87.65
40%
-76
- C3 -
1SES
1
SYS_THET2
A:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
----
Q
----
E
----
P
E
V
--
F
H
R
A
I
R
E
K
G
---------
V
A
--
L
D
L
E
A
L
L
A
----------
L
D
R
E
V
Q
E
--------
L
K
K
R
L
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
-
K
--
A
P
--
P
--------
E
----------
E
-
K
------------------------
E
---------------------------
A
-------------------------------
L
I
A
R
G
-----------------------
K
A
L
G
-
E
E
A
K
--
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
-
E
E
A-
N
-
R
--
E
--
I
K
R
V
G
G
P
--------
P
E
F
--------------------
S
-
F
-------------
P
P
-
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
-
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
-----------
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
---
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
--
S
L
E
A
S
D
--
R
A
F
--
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
---
Y
------
R
D
P
-
E
--
G
-
R
V
R
Y
A
Y
T
L
N
N
T
A
L
-
A
-
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
-
M
--
G
K
E
--
V
L
E
P
---------------
23
PsiBlast_CBE
87.60
40%
-77
- C3 -
1SET
1
SYS_THET2
B:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
----
Q
----
E
----
P
E
V
--
F
H
R
A
I
R
E
K
G
---------
V
A
--
L
D
L
E
A
L
L
A
----------
L
D
R
E
V
Q
E
--------
L
K
K
R
L
Q
EVQ
T
E
R
N
Q
V
A
K
R
V
P
-
K
--
A
P
--
P
--------
E
----------
E
-
K
------------------------
E
---------------------------
A
-------------------------------
L
I
A
R
G
-----------------------
K
A
L
G
-
E
E
A
K
--
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
-
E
E
A-
N
-
R
--
E
--
I
K
R
V
G
G
P
--------
P
E
F
--------------------
S
-
F
-------------
P
P
-
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
-
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
-----------
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
---
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
--
S
LE
A
S
D
--
R
A
F
--
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
---
Y
------
R
D
P
-
E
--
G
-
R
V
R
Y
A
Y
T
L
N
N
T
A
L
-
A
-
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
-
M
--
G
K
E
--
V
L
E
P
---------------
8
PsiBlast_PDB
87.00
40%
-75
- C3 -
1SET
1
SYS_THET2
A:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
----
Q
----
E
----
P
E
V
--
F
H
R
A
I
R
E
K
G
---------
V
A
--
L
D
L
E
A
L
L
A
----------
L
D
R
E
V
Q
E
--------
L
K
K
R
L
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
-
K
--
A
P
--
P
--------
E
----------
E
-
K
------------------------
E
---------------------------
A
-------------------------------
L
I
A
R
G
-----------------------
K
A
L
G
-
E
E
A
K
--
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
-
E
E
A-
N
-
R
--
E
--
I
K
R
V
G
G
P
--------
P
E
F
--------------------
S
-
F
-------------
P
P
-
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
-
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
-----------
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
---
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
--
S
L
E
A
S
D
--
R
A
F
--
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
---
Y
------
R
D
P
-
E
--
G
-
R
V
R
Y
A
Y
T
L
N
N
T
A
L
-
A
-
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
-
M
--
G
K
E
--
V
L
E
P
---------------
24
PsiBlast_CBE
86.14
40%
-75
- C3 -
1SES
1
SYS_THET2
B:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
----
Q
----
E
----
P
E
V
--
F
H
R
A
I
R
E
K
G
---------
V
A
--
L
D
L
E
A
L
L
A
----------
L
D
R
E
V
Q
E
--------
L
K
K
R
L
Q
EVQ
T
E
R
N
Q
V
A
K
R
V
P
-
K
--
A
P
--
P
--------
E
----------
E
-
K
------------------------
E
---------------------------
A
-------------------------------
L
I
A
R
G
-----------------------
K
A
L
G
-
E
E
A
K
--
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
-
E
E
A-
N
-
R
--
E
--
I
K
R
V
G
G
P
--------
P
E
F
--------------------
S
-
F
-------------
P
P
-
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
-
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
-----------
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
---
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
--
S
LE
A
S
D
--
R
A
F
--
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
---
Y
------
R
D
P
-
E
--
G
-
R
V
R
Y
A
Y
T
L
N
N
T
A
L
-
A
-
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
-
M
--
G
K
E
--
V
L
E
P
---------------
36
Fugue
84.95
35%
-78
- C3 -
3LSS
2
?
B:
[3-470]
-------------------------------------------------------------------------------------------G
S
M
M
V
L
D
I
Q
L
F
R
D
E
--
T
----
G
----
A
N
I
--
I
R
E
S
Q
R
R
R
F
A
--
D
-
P
--
D
I
V
--
D
A
I
I
E
A
D
K
----------
K
W
R
R
T
Q
F
--------
L
T
E
A
S
K
---
K
L
I
N
I
C
S
K
A
V
G
-
A
--
K
K
--
K
--------
A
----------
K
-
E
------------------------
A
---------------------------
D
GDTSEIP
P
Q
V
K
E
A
Y
E
N
GTLK
G
E
Q
V
E
Q
LC
V
L
Q
L
K
Q
L
S
-----------------------
K
D
L
S
-
D
Q
V
A
--
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
I
A
-
Q
-
D
E
--
E
-
T
--
G
NT
V
V
R
T
F
G
N
--------
T
T
K
----------------------
R
-------------
A
K
-
L
-
N
------------
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
V
T
-
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
-
S
Q
F
D
-
E
E
L
Y
Q
V
----
S
G
---
D
G
D
K
---------
K
Y
L
I
A
T
S
E
M
P
I
A
A
Y
---
H
R
G
R
W
F
--
T
--
E
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
--
R
QE
E
S
W
--
R
H
L
--
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
---
Y
G
P
N
L
R
G
T
A
A
-
Q
--
N
-
V
K
E
Y
C
H
M
L
N
G
T
-
L
-
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
-
M
M-
G
I
E
--
M
I
R
F
E
--------------
50
HHSearch
84.12
34%
-77
- C3 -
3QNE
-
SYSC_CANAL
A:
[1-437]
-----------------------------------------------------------------------------------------------
M
L
D
I
N
A
F
L
VEKG
G
----
D
----
P
E
I
--
I
K
A
S
Q
K
K
R
G
D
--
S
-
V
--
E
L
V
--
D
E
I
I
A
E
Y
K
----------
E
W
V
K
L
R
F
--------
D
L
D
E
H
N
---
K
K
L
N
S
V
Q
K
E
I
G
-
K
--
R
F
K
A
K
--------
E
----------
D
-
A
------------------------
K
---------------------------
D
-------------------------------
L
I
A
E
K
-----------------------
E
K
L
S
-
N
E
K
K
--
E
I
I
E
K
E
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
-
Q
-
D
E
--
E
N
N
--
E
--
L
V
R
T
W
T
P
--------
E
N
Y
KKPEQIAAAT----------
G
A
P
-------------
A
K
-
L
-
S
------------
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
-
S
Q
F
D
-
E
E
L
Y
K
V
----
I
D
GE-
D
E
-----------
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
---
H
A
G
E
W
F
ES
P
--
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
S
W
--
E
E
F
--
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
---
C
------
G
I
-------
E
K
K
Y
V
H
C
L
N
S
T
-
L
S
A
-
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
-
I
--
P
G
----------------------
11
PsiBlast_PDB
84.01
33%
-80
- C3 -
4RQF
2
SYSC_HUMAN
A:
[2-469]
-----------------------------------------------------------------------------------------------
V
L
D
L
D
L
F
R
----
V
----
D
KGGD
P
A
L
--
I
R
E
T
Q
E
K
R
F
K
--
D
-
P
--
G
L
V
--
D
Q
L
V
K
A
D
S
----------
E
W
R
R
C
R
F
--------
R
A
D
N
L
N
---
K
L
K
N
L
C
S
K
T
I
---------------------------------------------------------FDDLTADALANLK
V
-------------
S
-------------------------------
Q
I
K
K
V
-----------------------
R
L
L
I
D
E
A
I
L
--
K
C
D
A
E
R
I
K
L
E
A
E
R
F
E
N
L
R
E
I
G
N
L
L
H
P
S
V
P
I
S
-
N
-
D
E
--
D
-
V
DN
K
--
V
E
R
I
W
G
D
--------
C
T
---------------------
V
-
R
-------------
K
K
-
Y
-
S
------------
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
-
S
Q
F
D
-
E
E
L
Y
K
V
----
I
G
---
K
G
SEKSDDN
S
Y
D
E
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
---
H
R
D
E
W
L
--
R
--
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
H
G
R
D
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
N
K
S
W
E
M
F
--
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
---
Y
GQT-----
M
-
M
--
D
-
K
V
E
F
V
H
M
L
N
A
T
-
M
C
A
-
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
K
K
G
-
I
T
V
P
E
K
L
K
E
F
-
M
PP
G
L
Q
--
E
L
I
P
---------------
49
HHSearch
83.73
37%
-77
- C3 -
3VBB
2
SYSC_HUMAN
A:
[2-470]
-----------------------------------------------------------------------------------------------
V
L
D
L
D
L
F
R
----
V
DKGG
D
----
P
A
L
--
I
R
E
T
Q
E
K
R
F
K
--
D
-
P
--
G
L
V
--
D
Q
L
V
K
A
D
S
----------
E
W
R
R
C
R
F
--------
R
A
D
N
L
N
---
K
L
K
N
L
C
S
K
T
I
G
-
E
--
K
M
K
K
K
--------
E
-------------DESVPENVLSFDDLT
A
D
A
L
A
N
L
KV
S
---------------------------
Q
-------------------------------
I
K
K
V
R
-----------------------
L
L
I
D
-
E
A
I
L
--
K
C
D
A
E
R
I
K
L
E
A
E
R
F
E
N
L
R
E
I
G
N
L
L
H
P
S
V
P
I
S
-
N
-
D
E
D-
V
D
N
--
K
--
V
E
R
I
W
G
D
--------
C
T
V
----------------------
R
-------------
K
K
-
Y
-
S
------------
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
-
S
-
F
D
-
E
E
L
Y
K
V
----
I
----
D
E
-----------
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
---
H
R
D
E
W
L
--
R
--
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
----
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
DN
K
S
W
--
E
M
F
--
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
---
Y
------
G
Q
T
--M-
D
-
K
V
E
F
V
H
M
L
N
A
T
-
M
C
A
-
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
-
M
--
P
P
G
LQ
E
L
I
P
F
--------------
48
HHSearch
83.68
35%
-79
- C3 -
1WLE
1
SYSM_BOVIN
A:
[40-474]
-----------------------------------------------------------------------------------------------
L
L
D
M
E
S
L
C
----
A
----
Y
----
P
E
D
--
A
A
R
A
L
D
L
R
K
G
--
E
-
L
RS
K
D
L
--
P
G
I
I
S
T
W
Q
----------
E
L
R
Q
L
R
E
--------
Q
I
R
S
L
E
---
E
E
K
E
A
V
T
E
A
V
R
-
A
--
L
V
V
N
Q
DNSQVQQD
P
----------
Q
-
Y
------------------------
Q
---------------------------
S
-------------------------------
L
R
A
R
G
-----------------------
R
E
I
R
-
K
Q
L
T
--
L
L
Y
P
K
E
A
Q
L
E
E
Q
F
Y
L
R
A
L
R
L
P
N
Q
T
H
P
D
V
P
V
G
-
D
-
E
S
--
Q
-
A
--
R
--
V
L
H
V
V
G
D
--------
K
P
A
--------------------
F
S
F
-------------
Q
P
-
R
-
G
------------
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
-
S
-
H
V
S
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
L
I
H
R
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
-
P
N
A
K
P
S
Q
I
Y
N
I
----
D
P
SRF
E
D
-----------
L
N
L
A
G
T
A
E
V
G
L
A
G
Y
---
F
M
D
H
S
V
--
A
--
F
R
D
L
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
-
G
--
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
M
F
G
V
T
G
P
--
G
L
E
Q
S
S
--
E
L
L
--
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
---
F
------
Q
T
E
-
A
--
G
-
E
L
Q
F
A
H
T
V
N
A
T
-
G
C
A
-
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
-
L
--
G
T
D
--
R
I
T
----------------
33
PsiBlast_CBE
83.40
34%
-80
- C3 -
3LSS
2
?
B:
[7-467]
-----------------------------------------------------------------------------------------------
V
L
D
I
Q
L
F
R
----
D
----
E
----
T
G
A
N
I
I
R
E
S
Q
R
R
R
F
A
--
D
-
P
--
D
I
V
--
D
A
I
I
E
A
D
K
K
W
R
R
T
Q
F
L
T
E
A
S
K
K
L
I
N
--------
I
C
S
K
A
V
---
G
A
K
K
K
A
K
E
A
D
G
-
D
--
T
S
----------------------
E
-
I
------------------------
P
---------------------------
P
-------------------------------
Q
V
K
E
A
Y
E
N
GTLK
G
E
Q
V
E
Q
LC
V
L
Q
L
K
Q
L
S
K
D
L
S
-
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
--
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
I
A
-
Q
-
D
E
--
E
-
T
--
G
--
N
T
V
V
R
T
F
--------
G
N
T
--------------------
T
-
K
-------------
R
A
-
K
L
N
------------
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
V
T
-
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
-
S
Q
F
D
-
E
E
L
Y
Q
V
----
S
G
---
D
G
D
K
---------
K
Y
L
I
A
T
S
E
M
P
I
A
A
Y
---
H
R
G
R
W
F
--
T
--
E
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
--
R
--
Q
E
E
S
W
R
H
L
--
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
---
Y
G
P
N
L
R
G
T
A
A
-
Q
--
N
-
V
K
E
Y
C
H
M
L
N
G
T
-
L
C
A
-
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
V
V
-
I
P
D
V
L
R
P
Y
M
M
--
G
I
E
--
M
I
-----------------
13
PsiBlast_PDB
82.95
33%
-78
- C3 -
4L87
4
SYSC_HUMAN
A:
[1-468]
-----------------------------------------------------------------------------------------------
V
L
D
L
D
L
F
R
----
V
----
D
KGGD
P
A
L
--
I
R
E
T
Q
E
K
R
F
K
--
D
-
P
--
G
L
V
--
D
Q
L
V
K
A
D
S
----------
E
W
R
R
C
R
F
--------
R
A
D
N
L
N
---
K
L
K
N
L
C
S
K
T
I
G
-
E
--
K
M
--
K
--------
K
----------
K
-
E
------------------------
P
VGDDESVPENVLSFDDLT
A
D
A
L
A
N
LK
V
S
-------------------------------
Q
I
K
K
V
-----------------------
R
L
L
I
D
E
A
I
L
--
K
C
D
A
E
R
I
K
L
E
A
E
R
F
E
N
L
R
E
I
G
N
L
L
H
P
S
V
P
I
S
-
N
-
D
E
--
D
-
V
D
N
K
--
V
E
R
I
W
G
D
--------
C
T
---------------------
V
-
R
-------------
K
K
-
Y
-
S
------------
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
-
S
Q
F
D
-
E
E
L
Y
K
V
----
I
G
---
K
G
SEKSDDN
S
Y
D
E
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
---
H
R
D
E
W
L
--
R
--
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
H
G
R
D
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
N
K
S
W
E
M
F
--
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
---
Y
GQT---
K
K
M
-
M
--
D
-
K
V
E
F
V
H
M
L
N
A
T
-
M
C
A
-
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
-
M
PP
G
L
Q
--
E
L
I
P
---------------
46
HHSearch
82.93
35%
-67
- C3 -
3LSS
4
?
A:
[7-468]
-----------------------------------------------------------------------------------------------
V
L
D
I
Q
L
F
R
----
D
----
E
T
G
--
A
N
I
--
I
R
E
S
Q
R
R
R
F
A
--
D
-
P
--
D
I
V
--
D
A
I
I
E
A
D
K
----------
K
W
R
R
T
Q
F
--------
L
T
E
A
S
K
---
K
L
I
N
I
C
S
K
A
V
G
-
A
--
K
K
K
A
K
--------
E
----------
A
C
V
------------------------
L
---------------------------
Q
-------------------------------
L
K
Q
L
S
-----------------------
K
D
L
S
-
D
Q
V
A
--
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
I
A
-
Q
-
D
E
ET
G
-
N
--
T
--
V
V
R
T
F
G
N
--------
T
T
K
----------------------
R
-------------
A
K
-
L
-
N
------------
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
-
V
T
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
-
S
Q
F
D
-
E
E
L
Y
Q
V
----
S
G
D
G
-
D
K
-----------
K
Y
L
I
A
T
S
E
M
P
I
A
A
Y
---
H
R
G
R
W
F
--
T
--
E
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
--
R
QE
E
S
W
--
R
H
L
--
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
---
Y
------
G
P
N
-
L
RQ
N
-
V
K
E
Y
C
H
M
L
N
G
T
-
L
C
A
-
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
-
M
--
M
G
I
--
E
M
I
R
---------------
18
PsiBlast_PDB
82.52
33%
-72
- C3 -
3QO8
4
SYSC_CANAL
A:
[14-435]
----------------------------------------------------------------------------------------------------------------
D
----
P
E
I
--
I
K
A
S
Q
K
K
R
G
D
--
S
-
V
--
E
L
V
--
D
E
I
I
A
E
Y
K
----------
E
W
V
K
L
R
F
--------
D
L
D
E
H
N
---
K
K
L
N
S
V
Q
K
E
I
G
-
K
R
F
K
-----------------------
D
-
A
------------------------
K
---------------------------
D
-------------------------------
L
I
A
E
K
-----------------------
E
K
L
S
-
N
E
K
K
--
E
I
I
E
K
E
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
-
Q
-
D
E
--
E
-
N
--
N
--
E
L
V
R
T
W
T
--------
P
E
N
--------------------
Y
-
K
-------------
K
P
-
E
-
Q
IAAATGAPAKLS
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
-
S
Q
F
D
-
E
E
L
Y
K
V
I
---
D
G
E--
D
E
-----------
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
---
H
A
G
E
W
F
--
E
SP
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
S
H
G
K
D
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
S
W
--
E
E
F
--
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
CGI
K
-----------------
K
Y
V
H
C
L
N
S
T
-
L
S
A
-
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
L
V
-
I
P
E
V
L
R
K
Y
-
I
--------------------------
17
PsiBlast_PDB
82.12
33%
-72
- C3 -
3QO7
1
SYSC_CANAL
A:
[14-435]
----------------------------------------------------------------------------------------------------------------
D
----
P
E
I
--
I
K
A
S
Q
K
K
R
G
D
--
S
-
V
--
E
L
V
--
D
E
I
I
A
E
Y
K
----------
E
W
V
K
L
R
F
--------
D
L
D
E
H
N
---
K
K
L
N
S
V
Q
K
E
I
G
-
K
R
F
K
A
--
K
--------
E
----------
D
-
A
------------------------
K
---------------------------
D
-------------------------------
L
I
A
E
K
-----------------------
E
K
L
S
-
N
E
K
K
--
E
I
I
E
K
E
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
-
Q
-
D
E
--
E
-
N
--
N
--
E
L
V
R
T
W
T
--------
P
E
N
--------------------
Y
-
K
-------------
K
P
-
E
-
Q
IAAATGAPAKLS
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
-
S
Q
F
D
-
E
E
L
Y
K
V
I
---
D
G
E--
D
E
-----------
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
---
H
A
G
E
W
F
--
E
SP
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
S
W
--
E
E
F
--
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
CGI----------------
E
K
K
Y
V
H
C
L
N
S
T
-
L
S
A
-
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
L
V
-
I
P
E
V
L
R
K
Y
-
I
--------------------------
27
PsiBlast_CBE
82.09
33%
-78
- C3 -
4RQF
2
SYSC_HUMAN
B:
[2-469]
-----------------------------------------------------------------------------------------------
V
L
D
L
D
L
F
R
----
V
----
D
KGGD
P
A
L
--
I
R
E
T
Q
E
K
R
F
K
--
D
-
P
--
G
L
V
--
D
Q
L
V
K
A
D
S
----------
E
W
R
R
C
R
F
--------
R
A
D
N
L
N
---
K
L
K
N
L
C
S
K
T
I
G
-
E
--
K
M
--
K
--------
K
----------
K
-
E
------------------------
P
VGDD
E
S
V
P
E
NVLSFDDLT
A
D
A
L
A
N
LK
V
S
-------------------------------
Q
I
K
K
V
-----------------------
R
L
L
I
D
E
A
I
L
--
K
C
D
A
E
R
I
K
L
E
A
E
R
F
E
N
L
R
E
I
G
N
L
L
H
P
S
V
P
I
S
-
N
-
D
E
--
D
-
V
DN
K
--
V
E
R
I
W
G
D
--------
C
T
---------------------
V
-
R
-------------
K
K
-
Y
-
S
------------
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
-
S
Q
F
D
-
E
E
L
Y
K
V
----
I
G
---
K
G
SEKSDDN
S
Y
D
E
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
---
H
R
D
E
W
L
--
R
--
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
H
G
R
D
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
N
K
S
W
E
M
F
--
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
---
Y
GQT---
K
K
M
-
M
--
D
-
K
V
E
F
V
H
M
L
N
A
T
-
M
C
A
-
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
K
K
G
-
I
T
V
P
E
K
L
K
E
F
-
M
PP
G
L
Q
--
E
L
I
P
---------------
37
Fugue
81.73
37%
-71
- C3 -
3ERR
1
DYHC1_MOUSE (first)
A:
[3-529]
D
L
K
R
L
R
Q
E
P
E
V
F
H
R
A
I
R
E
K
GVALD
L
E
A
L
L
A
V
D
E
Q
L
H
K
Q
Q
E
V
I
A
D
K
Q
M
S
V
K
E
D
L
D
K
V
E
P
A
V
I
E
A
Q
N
A
V
K
S
IK
K
Q
H
L
V
E
V
R
S
MANPP
A
A
V
K
L
A
L
E
S
I
A
L
L
L
G
E
S
T
----
T
----
D
----
W
K
Q
--
I
R
S
I
I
M
R
E
N
F
--
I
-
P
--
T
I
V
N
F
S
A
E
E
I
S
D
A
----------
I
R
E
K
M
K
K
NYMSNPSY
N
Y
E
I
V
N
---
R
A
S
L
A
A
G
P
M
V
K
W
A
--
I
A
--
Q
--------
L
----------
N
-
Y
------------------------
A
---------------------------
D
-------------------------------
M
L
K
R
V
-----------------------
E
P
L
R
-
N
E
L
Q
--
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
-
E
E
--
A
-
N
--
R
--
E
I
K
R
V
G
G
--------
P
P
E
--------------------
F
-
S
-------------
F
P
P
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
-
W
E
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
-
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
-----------
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
---
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
--
R
A
F
--
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
---
Y
------
R
D
P
-
E
--
G
-
R
V
R
Y
A
Y
T
L
N
N
T
A
L
-
A
-
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
-
M
--
G
K
E
--
V
L
E
P
G
--------------
35
Fugue
81.41
33%
-78
- C3 -
1WLE
1
SYSM_BOVIN
A:
[24-490]
-------------------------------------------------------------------------------RN
L
L
Y
E
H
A
R
E
GYSALP
L
L
D
M
E
S
L
C
----
A
----
Y
----
P
E
D
--
A
A
R
A
L
D
L
R
K
G
--
E
-
L
RS
K
D
L
--
P
G
I
I
S
T
W
Q
----------
E
L
R
Q
L
R
E
--------
Q
I
R
S
L
E
---
E
E
K
E
A
V
T
E
A
V
R
-
A
--
L
V
--
V
--------
N
Q
DNSQVQQD
P
Q
-
Y
------------------------
Q
---------------------------
S
-------------------------------
L
R
A
R
G
-----------------------
R
E
I
R
-
K
Q
L
T
--
L
L
Y
P
K
E
A
Q
L
E
E
Q
F
Y
L
R
A
L
R
L
P
N
Q
T
H
P
D
V
P
V
G
-
D
-
E
S
--
Q
-
A
--
R
--
V
L
H
V
V
G
D
--------
K
P
A
--------------------
F
-
S
F------------
Q
P
-
R
-
G
------------
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
-
S
-
H
V
S
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
L
I
H
R
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
-
P
N
A
K
-
P
S
Q
I
Y
N
I
DPS
R
F
---
E
D
-----------
L
N
L
A
G
T
A
E
V
G
L
A
G
Y
---
F
M
D
H
S
V
--
A
--
F
R
D
L
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
---
G
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
M
F
G
V
T
G
P
G
L
E
--
Q
S
S
--
E
L
L
--
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
---
F
------
Q
T
E
-
A
--
G
-
E
L
Q
F
A
H
T
V
N
A
T
G
C
-
A
-
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
-
L
--
G
T
D
--
R
I
T
T
P
T
HVPLQYIGPNQPQ
15
PsiBlast_PDB
81.04
34%
-76
- C3 -
3LSS
4
?
A:
[7-467]
-----------------------------------------------------------------------------------------------
V
L
D
I
Q
L
F
R
----
D
----
E
----
T
G
A
N
I
I
R
E
S
Q
R
R
R
F
A
--
D
-
P
--
D
I
V
--
D
A
I
I
E
A
D
K
K
W
R
R
T
Q
F
L
T
E
A
S
K
K
L
I
N
--------
I
C
S
K
A
V
---
G
A
K
K
K
A
K
E
A
--------------------------------------------------------------------------------------------------------------------------C
V
L
Q
L
K
Q
L
S
--------------
K
D
L
S
-
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
--
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
I
A
-
Q
-
D
E
--
E
-
T
--
G
--
N
T
V
V
R
T
F
--------
G
N
T
--------------------
T
-
K
-------------
R
A
-
K
L
N
------------
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
V
T
-
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
-
S
Q
F
D
-
E
E
L
Y
Q
V
----
S
G
---
D
G
D
K
---------
K
Y
L
I
A
T
S
E
M
P
I
A
A
Y
---
H
R
G
R
W
F
--
T
--
E
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
--
R
--
Q
E
E
S
W
R
H
L
--
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
---
Y
GPNLR-----
Q
--
N
-
V
K
E
Y
C
H
M
L
N
G
T
-
L
C
A
-
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
V
V
-
I
P
D
V
L
R
P
Y
M
M
--
G
I
E
--
M
I
-----------------
25
PsiBlast_CBE
79.06
41%
-82
- C3 -
3ERR
1
SYS_THET2
B:
[178-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
K
R
V
-----------------------
E
P
L
R
-
N
E
L
Q
--
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
-
E
E
A-
N
-
R
--
E
--
I
K
R
V
G
G
P
--------
P
E
F
--------------------
S
-
F
-------------
P
P
-
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
-
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
-----------
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
---
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
--
S
LE
A
S
D
--
R
A
F
--
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
---
Y
------
R
D
P
-
E
--
G
-
R
V
R
Y
A
Y
T
L
N
N
T
A
L
-
A
-
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
-
M
--
G
K
E
--
V
L
E
P
---------------
9
PsiBlast_PDB
79.00
41%
-81
- C3 -
3ERR
1
DYHC1_MOUSE (first)
A:
[178-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
K
R
V
-----------------------
E
P
L
R
-
N
E
L
Q
--
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
-
E
E
A-
N
-
R
--
E
--
I
K
R
V
G
G
P
--------
P
E
F
--------------------
S
-
F
-------------
P
P
-
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
-
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
-----------
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
---
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
--
S
L
E
A
S
D
--
R
A
F
--
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
---
Y
------
R
D
P
-
E
--
G
-
R
V
R
Y
A
Y
T
L
N
N
T
A
L
-
A
-
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
-
M
--
G
K
E
--
V
L
E
P
---------------
51
HHSearch
78.31
42%
-83
- C3 -
3ERR
1
DYHC1_MOUSE (first)
A:
[178-529]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
K
R
V
-----------------------
E
P
L
R
-
N
E
L
Q
--
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
-
E
E
--
A
-
N
--
R
--
E
I
K
R
V
G
G
--------
P
P
E
--------------------
F
S
F
-------------
P
P
-
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
W
E
P
-
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
-
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
-----------
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
---
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
--
R
A
F
--
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
---
Y
------
R
D
P
-
E
--
G
-
R
V
R
Y
A
Y
T
L
N
N
T
-
A
L
A
-
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
-
M
--
G
K
E
--
V
L
E
P
G
--------------
20
PsiBlast_PDB
74.45
37%
-81
- C3 -
1WLE
1
SYSM_BOVIN
A:
[99-471]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
R
A
L
V
V
--------
N
Q
D
N
S
Q
---
V
Q
Q
D
P
Q
Y
Q
S
---------------------------------------------------------------------------------------------------------------------
L
R
A
R
G
-----------------------
R
E
I
R
-
K
Q
L
T
--
L
L
Y
P
K
E
A
Q
L
E
E
Q
F
Y
L
R
A
L
R
L
P
N
Q
T
H
P
D
V
P
V
G
-
D
-
E
S
--
Q
-
A
--
R
--
V
L
H
V
V
G
D
K-------
P
A
F
--------------------
S
-
F
-------------
Q
P
-
R
-
G
------------
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
-
S
-
H
V
S
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
L
I
H
R
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
P
N
A
K
P
-
S
Q
I
Y
N
I
----
D
P
SRF
E
D
-----------
L
N
L
A
G
T
A
E
V
G
L
A
G
Y
F
MD
H
S
V
A
F
R
--
D
--
L
---
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
-
G
--
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
M
F
G
V
T
G
P
--
G
--
L
E
Q
--
S
S
E
L
L
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
---
F
------
Q
T
E
-
A
--
G
-
E
L
Q
F
A
H
T
V
N
A
T
G
C
-
A
-
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
-
L
--
G
T
D
---------------------
34
PsiBlast_CBE
72.71
37%
-77
- C3 -
1WLE
1
SYSM_BOVIN
B:
[99-471]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
R
A
L
V
V
--------
N
Q
D
N
S
Q
---
V
Q
Q
D
P
Q
Y
Q
S
---------------------------------------------------------------------------------------------------------------------
L
R
A
R
G
-----------------------
R
E
I
R
-
K
Q
L
T
--
L
L
Y
P
K
E
A
Q
L
E
E
Q
F
Y
L
R
A
L
R
L
P
N
Q
T
H
P
D
V
P
V
G
-
D
-
E
S
--
Q
-
A
--
R
--
V
L
H
V
V
G
D
K-------
P
A
F
--------------------
S
-
F
-------------
Q
P
-
R
-
G
------------
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
-
S
-
H
V
S
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
L
I
H
R
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
P
N
A
K
P
-
S
Q
I
Y
N
I
----
D
P
SRF
E
D
-----------
L
N
L
A
G
T
A
E
V
G
L
A
G
Y
F
MD
H
S
V
A
F
R
--
D
--
L
---
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
-
G
K
E
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
M
F
G
V
T
G
P
--
G
--
L
E
Q
--
S
S
E
L
L
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
---
F
------
Q
T
E
-
A
--
G
-
E
L
Q
F
A
H
T
V
N
A
T
G
C
-
A
-
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
-
L
--
G
T
D
---------------------