@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1195: (2016-01-27 )
MFKHIIARTPARSLVDGLTSSHLGKPDYAKALEQHNAYIRALQTCDVDITLLPPDERFPDSVFVEDPVLCTSRCAIITRPGAESRRGETEIIEETVQRFYPGKVERIEAPGTVEAGDIMMVGDHFYIGESARTNAEGARQMIAILEKHGLSGSVVRLEKVLHLKTGLAYLEHNNLLAAGEFVSKPEFQDFNIIEIPEEESYAANCIWVNERVIMPAGYPRTREKIARLGYRVIEVDTSEYRKIDGGVSCMSLRF
Atome Classification :
(20 SA)
-.........10.....-.--..-20--..-----------.---......30........40..-.-.....50.....-----...60------.........70........80........90........100---------------------....---------------...110.......120.......130.......140.......150.....--..160.......170.......---------180..-------..------.--..190....-----...200-----........-.----210...---.---....220.....-.-.230.......240.......250..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
F
K
H
I
IART
P
A
R
S
L
V
D
-
G
--
L
T
-
S
---SH-----------L---GK
P
D
Y
A
K
A
L
E
QH
N
A
Y
I
R
A
L
Q
-T-CD
V
D
I
T
LLPPDE-----RFPD-------SVFVEDPVLCTS
R
C
A
I
I
TRPGAESRRG
E
T
E
I
I
E
E
T
V
Q
R
FYPG---------------------K
V
E
R
---------------IEAPGTVEAG
D
I
M
M
VGD
H
F
Y
IGESART
N
A
E
G
A
R
Q
M
I
A
I
L
E
KHGLS
G
S
V
V
R
L
--
E
K
V
L
H
L
K
T
G
L
A
Y
LEHN
N
L
L
AAG---------EFVSK-------PE------F--QDF
N
I
I
EIP-----EEES-------YA
A
N
C
I
W
V-N----E-
R
V
I
M---P---AGY
P
R
T
R
E
K
I
A
R
-L-G
Y
R
V
I
EVD
T
S
E
Y
RKIDGGV
S
C
M
SLRF
21
HHSearch
98.63
100%
-106
- C3 -
1H70
1
DDAH_PSEAE
A:
[2-255]
-
M
F
K
H
I
I
A
R
T
P
A
R
S
L
V
D
-
G
--
L
T
-
S
---
S
H
-----------
L
---
G
K
P
D
Y
A
K
A
L
E
Q
H
N
A
Y
I
R
A
L
Q
-
T
-
C
D
V
D
I
T
L
L
P
P
D
E
-----
R
F
P
D
-------
S
V
F
V
E
D
P
V
L
C
T
S
R
C
A
I
I
T
R
P
G
A
E
S
R
R
G
E
T
E
I
I
E
E
T
V
Q
R
F
Y
P
G
---------------------
K
V
E
R
---------------
I
E
A
P
G
T
V
E
A
G
D
I
M
M
V
G
D
H
F
Y
I
G
E
S
A
R
T
N
A
E
G
A
R
Q
M
I
A
I
L
E
K
H
G
L
S
G
S
V
V
R
L
--
E
K
V
L
H
L
K
T
G
L
A
Y
L
E
H
N
N
L
L
A
A
G
---------
E
F
V
S
K
-------
P
E
------
F
--
Q
D
F
N
I
I
E
I
P
-----
E
E
E
S
-------
Y
A
A
N
C
I
W
V
-
N
----
E
-
R
V
I
M
---
P
---
A
G
Y
P
R
T
R
E
K
I
A
R
-
L
-
G
Y
R
V
I
E
V
D
T
S
E
Y
R
K
I
D
G
G
V
S
S
M
S
L
R
F
2
PsiBlast_PDB
98.43
99%
-106
- C3 -
1H70
1
DDAH_PSEAE
A:
[2-255]
-
M
F
K
H
I
I
A
R
T
P
A
R
S
L
V
D
-
G
--
L
T
-
S
---
S
H
-----------
L
---
G
K
P
D
Y
A
K
A
L
E
Q
H
N
A
Y
I
R
A
L
Q
-
T
-
C
D
V
D
I
T
L
L
P
P
D
E
-----
R
F
P
D
-------
S
V
F
V
E
D
P
V
L
C
T
S
R
C
A
I
I
T
R
P
G
A
E
S
R
R
G
E
T
E
I
I
E
E
T
V
Q
R
F
Y
P
G
---------------------
K
V
E
R
---------------
I
E
A
P
G
T
V
E
A
G
D
I
M
M
V
G
D
H
F
Y
I
G
E
S
A
R
T
N
A
E
G
A
R
Q
M
I
A
I
L
E
K
H
G
L
S
G
S
V
V
R
L
--
E
K
V
L
H
L
K
T
G
L
A
Y
L
E
H
N
N
L
L
A
A
G
---------
E
F
V
S
K
-------
P
E
------
F
--
Q
D
F
N
I
I
E
I
P
-----
E
E
E
S
-------
Y
A
A
N
C
I
W
V
-
N
----
E
-
R
V
I
M
---
P
---
A
G
Y
P
R
T
R
E
K
I
A
R
-
L
-
G
Y
R
V
I
E
V
D
T
S
E
Y
R
K
I
D
G
G
V
S
S
M
S
L
R
F
36
Fugue
98.42
99%
-106
- C3 -
1H70
1
DDAH_PSEAE
A:
[1-255]
F
M
F
K
H
I
I
A
R
T
P
A
R
S
L
V
D
-
G
--
L
T
-
S
---
S
H
-----------
L
---
G
K
P
D
Y
A
K
A
L
E
Q
H
N
A
Y
I
R
A
L
Q
-
T
-
C
D
V
D
I
T
L
L
P
P
D
E
-----
R
F
P
D
-------
S
V
F
V
E
D
P
V
L
C
T
S
R
C
A
I
I
T
R
P
G
A
E
S
R
R
G
E
T
E
I
I
E
E
T
V
Q
R
F
Y
P
G
---------------------
K
V
E
R
---------------
I
E
A
P
G
T
V
E
A
G
D
I
M
M
V
G
D
H
F
Y
I
G
E
S
A
R
T
N
A
E
G
A
R
Q
M
I
A
I
L
E
K
H
G
L
S
G
S
V
V
R
L
--
E
K
V
L
H
L
K
T
G
L
A
Y
L
E
H
N
N
L
L
A
A
G
---------
E
F
V
S
K
-------
P
E
------
F
--
Q
D
F
N
I
I
E
I
P
-----
E
E
E
S
-------
Y
A
A
N
C
I
W
V
-
N
----
E
-
R
V
I
M
---
P
---
A
G
Y
P
R
T
R
E
K
I
A
R
-
L
-
G
Y
R
V
I
E
V
D
T
S
E
Y
R
K
I
D
G
G
V
S
S
M
S
L
R
F
19
PsiBlast_CBE
97.86
100%
-114
- C3 -
3RHY
1
DDAH_PSEAE
B:
[1-254]
-
M
F
K
H
I
I
A
R
T
P
A
R
S
L
V
D
------------------------
L
---
G
K
P
D
Y
A
K
A
L
E
Q
H
N
A
Y
I
R
A
L
Q
-
T
-
C
D
V
D
I
T
L
L
P
P
D
E
-----
R
F
P
D
-------
S
V
F
V
E
D
P
V
L
C
T
S
R
C
A
I
I
T
R
P
G
A
E
S
R
R
G
E
T
E
I
I
E
E
T
V
Q
R
F
Y
P
G
---------------------
K
V
E
R
---------------
I
E
A
P
G
T
V
E
A
G
D
I
M
M
V
G
D
H
F
Y
I
G
E
S
A
R
T
N
A
E
G
A
R
Q
M
I
A
I
L
E
K
H
G
L
S
G
S
V
V
R
L
--
E
K
V
L
H
L
K
T
G
L
A
Y
L
E
H
N
N
L
L
A
A
G
---------
E
F
V
S
K
-------
P
E
------
F
--
Q
D
F
N
I
I
E
I
P
-----
E
E
E
S
-------
Y
A
A
N
C
I
W
V
-
N
----
E
-
R
V
I
M
---
P
---
A
G
Y
P
R
T
R
E
K
I
A
R
-
L
-
G
Y
R
V
I
E
V
D
T
S
E
Y
R
K
I
D
G
G
V
S
C
M
S
L
R
F
20
PsiBlast_CBE
97.61
99%
-107
- C3 -
3BPB
1
DDAH_PSEAE
B:
[1-254]
-
M
F
K
H
I
I
A
R
T
P
A
R
S
L
V
D
-
G
--
L
T
-
S
---
S
H
-----------
L
---
G
K
P
D
Y
A
K
A
L
E
Q
H
N
A
Y
I
R
A
L
Q
-
T
-
C
D
V
D
I
T
L
L
P
P
D
E
-----
R
F
P
D
-------
S
V
F
V
E
D
P
V
L
C
T
S
R
C
A
I
I
T
R
P
G
A
E
S
R
R
G
E
T
E
I
I
E
E
T
V
Q
R
F
Y
P
G
---------------------
K
V
E
R
---------------
I
E
A
P
G
T
V
E
A
G
D
I
M
M
V
G
D
H
F
Y
I
G
E
S
A
R
T
N
A
E
G
A
R
Q
M
I
A
I
L
E
K
H
G
L
S
G
S
V
V
R
L
--
E
K
V
L
G
L
K
T
G
L
A
Y
L
E
H
N
N
L
L
A
A
G
---------
E
F
V
S
K
-------
P
E
------
F
--
Q
D
F
N
I
I
E
I
P
-----
E
E
E
S
-------
Y
A
A
N
C
I
W
V
-
N
----
E
-
R
V
I
M
---
P
---
A
G
Y
P
R
T
R
E
K
I
A
R
-
L
-
G
Y
R
V
I
E
V
D
T
S
E
Y
R
K
I
D
G
G
V
S
C
M
S
L
R
F
1
PsiBlast_PDB
97.53
100%
-111
- C3 -
3RHY
1
DDAH_PSEAE
A:
[1-254]
-
M
F
K
H
I
I
A
R
T
P
A
R
S
L
V
D
------------------------
L
---
G
K
P
D
Y
A
K
A
L
E
Q
H
N
A
Y
I
R
A
L
Q
-
T
-
C
D
V
D
I
T
L
L
P
P
D
E
-----
R
F
P
D
-------
S
V
F
V
E
D
P
V
L
C
T
S
R
C
A
I
I
T
R
P
G
A
E
S
R
R
G
E
T
E
I
I
E
E
T
V
Q
R
F
Y
P
G
---------------------
K
V
E
R
---------------
I
E
A
P
G
T
V
E
A
G
D
I
M
M
V
G
D
H
F
Y
I
G
E
S
A
R
T
N
A
E
G
A
R
Q
M
I
A
I
L
E
K
H
G
L
S
G
S
V
V
R
L
--
E
K
V
L
H
L
K
T
G
L
A
Y
L
E
H
N
N
L
L
A
A
G
---------
E
F
V
S
K
-------
P
E
------
F
--
Q
D
F
N
I
I
E
I
P
-----
E
E
E
S
-------
Y
A
A
N
C
I
W
V
-
N
----
E
-
R
V
I
M
---
P
---
A
G
Y
P
R
T
R
E
K
I
A
R
-
L
-
G
Y
R
V
I
E
V
D
T
S
E
Y
R
K
I
D
G
G
V
S
C
M
S
L
R
F
3
PsiBlast_PDB
97.16
99%
-107
- C3 -
3BPB
1
DDAH_PSEAE
A:
[1-254]
-
M
F
K
H
I
I
A
R
T
P
A
R
S
L
V
D
-
G
--
L
T
-
S
---
S
H
-----------
L
---
G
K
P
D
Y
A
K
A
L
E
Q
H
N
A
Y
I
R
A
L
Q
-
T
-
C
D
V
D
I
T
L
L
P
P
D
E
-----
R
F
P
D
-------
S
V
F
V
E
D
P
V
L
C
T
S
R
C
A
I
I
T
R
P
G
A
E
S
R
R
G
E
T
E
I
I
E
E
T
V
Q
R
F
Y
P
G
---------------------
K
V
E
R
---------------
I
E
A
P
G
T
V
E
A
G
D
I
M
M
V
G
D
H
F
Y
I
G
E
S
A
R
T
N
A
E
G
A
R
Q
M
I
A
I
L
E
K
H
G
L
S
G
S
V
V
R
L
--
E
K
V
L
G
L
K
T
G
L
A
Y
L
E
H
N
N
L
L
A
A
G
---------
E
F
V
S
K
-------
P
E
------
F
--
Q
D
F
N
I
I
E
I
P
-----
E
E
E
S
-------
Y
A
A
N
C
I
W
V
-
N
----
E
-
R
V
I
M
---
P
---
A
G
Y
P
R
T
R
E
K
I
A
R
-
L
-
G
Y
R
V
I
E
V
D
T
S
E
Y
R
K
I
D
G
G
V
S
C
M
S
L
R
F
4
PsiBlast_PDB
70.19
29%
-92
- C3 -
2C6Z
2
DDAH1_BOVIN
A:
[14-276]
----
H
V
V
V
R
A
L
P
E
S
L
A
Q
Q
A
--
L
R
-
R
---
T
K
-----------
G
---
D
E
V
D
F
A
R
A
E
R
Q
H
Q
L
Y
V
G
V
L
G
-
S
K
L
G
L
Q
V
V
Q
L
P
A
D
E
-----
S
L
P
D
-------
C
V
F
V
E
D
V
A
V
V
C
E
E
T
A
L
I
T
R
P
G
A
P
S
R
R
K
E
A
D
M
M
K
E
A
L
E
K
L
Q
L
N
---------------------
I
V
E
M
---------------
K
D
E
N
A
T
L
D
G
G
D
V
L
F
T
G
R
E
F
F
V
G
L
S
K
R
T
N
Q
R
G
A
E
I
L
A
D
T
F
K
D
Y
A
V
--
S
T
V
P
V
--
V
D
A
L
H
L
K
S
-
F
C
S
M
A
G
P
N
L
I
A
I
G
SS
E
S
A
Q
K
A
L
K
I
M
Q
Q
-------
M
S
------
D
--
H
R
Y
D
K
L
T
V
P
-----
D
D
---------
T
A
A
N
C
I
Y
L
-
N
I
P
SK
G
-
H
V
L
L
H
R
T
P
---
E
E
Y
P
E
S
A
K
V
Y
E
K
-
L
K
D
H
M
L
I
P
V
S
N
S
E
L
E
K
V
D
G
L
L
T
C
S
S
V
L
I
7
PsiBlast_PDB
69.98
29%
-91
- C3 -
2CI5
1
DDAH1_BOVIN
A:
[14-276]
----
H
V
V
V
R
A
L
P
E
S
L
A
Q
Q
A
--
L
R
-
R
---
T
K
-----------
G
---
D
E
V
D
F
A
R
A
E
R
Q
H
Q
L
Y
V
G
V
L
G
-
S
K
L
G
L
Q
V
V
Q
L
P
A
D
E
-----
S
L
P
D
-------
C
V
F
V
E
D
V
A
V
V
C
E
E
T
A
L
I
T
R
P
G
A
P
S
R
R
K
E
A
D
M
M
K
E
A
L
E
K
L
Q
L
N
---------------------
I
V
E
M
---------------
K
D
E
N
A
T
L
D
G
G
D
V
L
F
T
G
R
E
F
F
V
G
L
S
K
R
T
N
Q
R
G
A
E
I
L
A
D
T
F
K
D
Y
A
V
--
S
T
V
P
V
--
V
D
A
L
H
L
K
S
-
F
C
S
M
A
G
P
N
L
I
A
I
G
SS
E
S
A
Q
K
A
L
K
I
M
Q
Q
-------
M
S
------
D
--
H
R
Y
D
K
L
T
V
P
-----
D
D
---------
T
A
A
N
C
I
Y
L
-
N
I
P
SK
G
-
H
V
L
L
H
R
T
P
---
E
E
Y
P
E
S
A
K
V
Y
E
K
-
L
K
D
H
M
L
I
P
V
S
N
S
E
L
E
K
V
D
G
L
L
T
C
S
S
V
L
I
9
PsiBlast_PDB
69.64
29%
-90
- C3 -
2CI7
2
DDAH1_BOVIN
A:
[14-276]
----
H
V
V
V
R
A
L
P
E
S
L
A
Q
Q
A
--
L
R
-
R
---
T
K
-----------
G
---
D
E
V
D
F
A
R
A
E
R
Q
H
Q
L
Y
V
G
V
L
G
-
S
K
L
G
L
Q
V
V
Q
L
P
A
D
E
-----
S
L
P
D
-------
C
V
F
V
E
D
V
A
V
V
C
E
E
T
A
L
I
T
R
P
G
A
P
S
R
R
K
E
A
D
M
M
K
E
A
L
E
K
L
Q
L
N
---------------------
I
V
E
M
---------------
K
D
E
N
A
T
L
D
G
G
D
V
L
F
T
G
R
E
F
F
V
G
L
S
K
R
T
N
Q
R
G
A
E
I
L
A
D
T
F
K
D
Y
A
V
--
S
T
V
P
V
--
V
D
A
L
H
L
K
S
-
F
C
S
M
A
G
P
N
L
I
A
I
G
SS
E
S
A
Q
K
A
L
K
I
M
Q
Q
-------
M
S
------
D
--
H
R
Y
D
K
L
T
V
P
-----
D
D
---------
T
A
A
N
C
I
Y
L
-
N
I
PSK
G
-
H
V
L
L
H
R
T
P
---
E
E
Y
P
E
S
A
K
V
Y
E
K
-
L
K
D
H
M
L
I
P
V
S
N
S
E
L
E
K
V
D
G
L
L
T
C
S
S
V
L
I
8
PsiBlast_PDB
69.48
29%
-94
- C3 -
2CI6
1
DDAH1_BOVIN
A:
[14-276]
----
H
V
V
V
R
A
L
P
E
S
L
A
Q
Q
A
--
L
R
-
R
---
T
K
-----------
G
---
D
E
V
D
F
A
R
A
E
R
Q
H
Q
L
Y
V
G
V
L
G
-
S
K
L
G
L
Q
V
V
Q
L
P
A
D
E
-----
S
L
P
D
-------
C
V
F
V
E
D
V
A
V
V
C
E
E
T
A
L
I
T
R
P
G
A
P
S
R
R
K
E
A
D
M
M
K
E
A
L
E
K
L
Q
L
N
---------------------
I
V
E
M
---------------
K
D
E
N
A
T
L
D
G
G
D
V
L
F
T
G
R
E
F
F
V
G
L
S
K
R
T
N
Q
R
G
A
E
I
L
A
D
T
F
K
D
Y
A
V
--
S
T
V
P
V
--
V
D
A
L
H
L
K
S
-
F
C
S
M
A
G
P
N
L
I
A
I
G
SS
E
S
A
Q
K
A
L
K
I
M
Q
Q
-------
M
S
------
D
--
H
R
Y
D
K
L
T
V
P
-----
D
D
---------
T
A
A
N
C
I
Y
L
-
N
I
PSK
G
-
H
V
L
L
H
R
T
P
---
E
E
Y
P
E
S
A
K
V
Y
E
K
-
L
K
D
H
M
L
I
P
V
S
N
S
E
L
E
K
V
D
G
L
L
T
C
S
S
V
L
I
5
PsiBlast_PDB
69.48
29%
-92
- C3 -
2CI3
-
DDAH1_BOVIN
A:
[14-276]
----
H
V
V
V
R
A
L
P
E
S
L
A
Q
Q
A
--
L
R
-
R
---
T
K
-----------
G
---
D
E
V
D
F
A
R
A
E
R
Q
H
Q
L
Y
V
G
V
L
G
-
S
K
L
G
L
Q
V
V
Q
L
P
A
D
E
-----
S
L
P
D
-------
C
V
F
V
E
D
V
A
V
V
C
E
E
T
A
L
I
T
R
P
G
A
P
S
R
R
K
E
A
D
M
M
K
E
A
L
E
K
L
Q
L
N
---------------------
I
V
E
M
---------------
K
D
E
N
A
T
L
D
G
G
D
V
L
F
T
G
R
E
F
F
V
G
L
S
K
R
T
N
Q
R
G
A
E
I
L
A
D
T
F
K
D
Y
A
V
--
S
T
V
P
V
--
V
D
A
L
H
L
K
S
-
F
C
S
M
A
G
P
N
L
I
A
I
G
SS
E
S
A
Q
K
A
L
K
I
M
Q
Q
-------
M
S
------
D
--
H
R
Y
D
K
L
T
V
P
-----
D
D
---------
T
A
A
N
C
I
Y
L
-
N
I
P
SK
G
-
H
V
L
L
H
R
T
P
---
E
E
Y
P
E
S
A
K
V
Y
E
K
-
L
K
D
H
M
L
I
P
V
S
N
S
E
L
E
K
V
D
G
L
L
T
C
S
S
V
L
I
6
PsiBlast_PDB
69.38
29%
-90
- C3 -
2CI4
-
DDAH1_BOVIN
A:
[14-276]
----
H
V
V
V
R
A
L
P
E
S
L
A
Q
Q
A
--
L
R
-
R
---
T
K
-----------
G
---
D
E
V
D
F
A
R
A
E
R
Q
H
Q
L
Y
V
G
V
L
G
-
S
K
L
G
L
Q
V
V
Q
L
P
A
D
E
-----
S
L
P
D
-------
C
V
F
V
E
D
V
A
V
V
C
E
E
T
A
L
I
T
R
P
G
A
P
S
R
R
K
E
A
D
M
M
K
E
A
L
E
K
L
Q
L
N
---------------------
I
V
E
M
---------------
K
D
E
N
A
T
L
D
G
G
D
V
L
F
T
G
R
E
F
F
V
G
L
S
K
R
T
N
Q
R
G
A
E
I
L
A
D
T
F
K
D
Y
A
V
--
S
T
V
P
V
--
V
D
A
L
H
L
K
S
-
F
C
S
M
A
G
P
N
L
I
A
I
G
SS
E
S
A
Q
K
A
L
K
I
M
Q
Q
-------
M
S
------
D
--
H
R
Y
D
K
L
T
V
P
-----
D
D
---------
T
A
A
N
C
I
Y
L
-
N
I
PSK
G
-
H
V
L
L
H
R
T
P
---
E
E
Y
P
E
S
A
K
V
Y
E
K
-
L
K
D
H
M
L
I
P
V
S
N
S
E
L
E
K
V
D
G
L
L
T
C
S
S
V
L
I
12
PsiBlast_PDB
68.74
30%
-76
- C3 -
3I4A
1
DDAH1_HUMAN
A:
[38-300]
----
H
A
V
V
R
A
L
P
E
S
L
G
Q
H
A
--
L
R
-
S
---
A
K
-----------
G
---
E
E
V
D
V
A
R
A
E
R
Q
H
Q
L
Y
V
G
V
L
G
-
S
K
L
G
L
Q
V
V
E
L
P
A
D
E
-----
S
L
P
D
-------
C
V
F
V
E
D
V
A
V
V
C
E
E
T
A
L
I
T
R
P
G
A
P
S
R
R
K
E
V
D
M
M
K
E
A
L
E
K
L
Q
L
N
---------------------
I
V
E
M
---------------
K
D
E
N
A
T
L
D
G
G
D
V
L
F
T
G
R
E
F
F
V
G
L
S
K
R
T
N
Q
R
G
A
E
I
L
A
D
T
F
K
D
Y
A
V
--
S
T
V
P
V
--
A
D
G
L
H
L
K
S
-
F
C
S
M
A
G
P
N
L
I
A
I
G
---------
S
S
E
S
A
Q
K
A
L
K
I
M
Q
Q
------
M
--
S
D
H
R
Y
D
K
L
T
-----
V
P
D
D
-------
I
A
A
N
C
I
Y
L
-
N
IPNK
G
-
H
V
L
L
H
RT
P
---
E
E
Y
P
E
S
A
K
V
Y
E
K
-
L
K
D
H
M
L
I
P
V
S
M
S
E
L
E
K
V
D
G
L
L
T
C
C
S
V
L
I
13
PsiBlast_PDB
68.06
30%
-78
- C3 -
3P8E
1
DDAH1_HUMAN
A:
[38-300]
----
H
A
V
V
R
A
L
P
E
S
L
G
Q
H
A
--
L
R
-
S
----------------
G
---
E
E
V
D
V
A
R
A
E
R
Q
H
Q
L
Y
V
G
V
L
G
-
S
K
L
G
L
Q
V
V
E
L
P
A
D
E
-----
S
L
P
D
-------
C
V
F
V
E
D
V
A
V
V
C
E
E
T
A
L
I
T
R
P
G
A
P
S
R
R
K
E
V
D
M
M
K
E
A
L
E
K
L
Q
L
N
---------------------
I
V
E
M
---------------
K
D
E
N
A
T
L
D
G
G
D
V
L
F
T
G
R
E
F
F
V
G
L
S
K
R
T
N
Q
R
G
A
E
I
L
A
D
T
F
K
D
Y
A
V
--
S
T
V
P
V
--
A
D
G
L
H
L
K
S
-
F
C
S
M
A
G
P
N
L
I
A
I
G
---------
S
S
E
S
A
Q
K
A
L
K
I
M
Q
Q
------
M
--
S
D
H
R
Y
D
K
L
T
-----
V
P
D
D
-------
I
A
A
N
C
I
Y
L
-
N
I
PNK
G
-
H
V
L
L
H
R
T
P
---
E
E
Y
P
E
S
A
K
V
Y
E
K
-
L
K
D
H
M
L
I
P
V
S
M
S
E
L
E
K
V
D
G
L
L
T
C
C
S
V
L
I
14
PsiBlast_PDB
67.88
29%
-91
- C3 -
3P8P
1
DDAH1_HUMAN
A:
[38-300]
----
H
A
V
V
R
A
L
P
E
S
L
G
Q
H
A
--
L
R
-
S
---
A
K
-----------
G
---
E
E
V
D
V
A
R
A
E
R
Q
H
Q
L
Y
V
G
V
L
G
-
S
K
L
G
L
Q
V
V
E
L
P
A
D
E
-----
S
L
P
D
-------
C
V
F
V
E
D
V
A
V
V
C
E
E
T
A
L
I
T
R
P
G
A
P
S
R
R
K
E
V
D
M
M
K
E
A
L
E
K
L
Q
L
N
---------------------
I
V
E
M
---------------
K
D
E
N
A
T
L
D
G
G
D
V
L
F
T
G
R
E
F
F
V
G
L
S
K
R
T
N
Q
R
G
A
E
I
L
A
D
T
F
K
D
Y
A
V
--
S
T
V
P
V
--
A
D
G
L
H
L
K
S
-
F
C
S
M
A
G
P
N
L
I
A
I
G
SS
E
S
A
Q
K
A
L
K
I
M
Q
Q
-------
M
S
------
D
--
H
R
Y
D
K
L
T
V
P
-----
D
D
---------
I
A
A
N
C
I
Y
L
-
N
IPNK
G
-
H
V
L
L
H
RT
P
---
E
E
Y
P
E
S
A
K
V
Y
E
K
-
L
K
D
H
M
L
I
P
V
S
M
S
E
L
E
K
V
D
G
L
L
T
S
C
S
V
L
I
11
PsiBlast_PDB
67.65
30%
-74
- C3 -
3I2E
-
DDAH1_HUMAN
A:
[15-277]
----
H
A
V
V
R
A
L
P
E
S
L
G
Q
H
A
--
L
R
-
S
---
A
K
-----------
G
---
E
E
V
D
V
A
R
A
E
R
Q
H
Q
L
Y
V
G
V
L
G
-
S
K
L
G
L
Q
V
V
E
L
P
A
D
E
-----
S
L
P
D
-------
C
V
F
V
E
D
V
A
V
V
C
E
E
T
A
L
I
T
R
P
G
A
P
S
R
R
K
E
V
D
M
M
K
E
A
L
E
K
L
Q
L
N
---------------------
I
V
E
M
---------------
K
D
E
N
A
T
L
D
G
G
D
V
L
F
T
G
R
E
F
F
V
G
L
S
K
R
T
N
Q
R
G
A
E
I
L
A
D
T
F
K
D
Y
A
V
--
S
T
V
P
V
--
A
D
G
L
H
L
K
S
-
F
C
S
M
A
G
P
N
L
I
A
I
G
---------
S
S
E
S
A
Q
K
A
L
K
I
M
Q
Q
------
M
--
S
D
H
R
Y
D
K
L
T
-----
V
P
D
D
-------
I
A
A
N
C
I
Y
L
-
N
IPNK
G
-
H
V
L
L
H
R
T
P
---
E
E
Y
P
E
S
A
K
V
Y
E
K
-
L
K
D
H
M
L
I
P
V
S
M
S
E
L
E
K
V
D
G
L
L
T
C
C
S
V
L
I
10
PsiBlast_PDB
67.58
30%
-81
- C3 -
2JAJ
1
DDAH1_HUMAN
A:
[19-281]
----
H
A
V
V
R
A
L
P
E
S
L
G
Q
H
A
--
L
R
-
S
----------------
G
---
E
E
V
D
V
A
R
A
E
R
Q
H
Q
L
Y
V
G
V
L
G
-
S
K
L
G
L
Q
V
V
E
L
P
A
D
E
-----
S
L
P
D
-------
C
V
F
V
E
D
V
A
V
V
C
E
E
T
A
L
I
T
R
P
G
A
P
S
R
R
K
E
V
D
M
M
K
E
A
L
E
K
L
Q
L
N
---------------------
I
V
E
M
---------------
K
D
E
N
A
T
L
D
G
G
D
V
L
F
T
G
R
E
F
F
V
G
L
S
K
R
T
N
Q
R
G
A
E
I
L
A
D
T
F
K
D
Y
A
V
--
S
T
V
P
V
--
A
D
G
L
H
L
K
S
-
F
C
S
M
A
G
P
N
L
I
A
I
G
---------
S
S
E
S
A
Q
K
A
L
K
I
M
Q
Q
------
M
--
S
D
H
R
Y
D
K
L
T
-----
V
P
D
D
-------
I
A
A
N
C
I
Y
L
-
N
I
P
NK
G
-
H
V
L
L
H
R
T
P
---
E
E
Y
P
E
S
A
K
V
Y
E
K
-
L
K
D
H
M
L
I
P
V
S
M
S
E
L
E
K
V
D
G
L
L
T
C
C
S
V
L
I
23
HHSearch
67.42
28%
-72
* C3 *
3I4A
1
DDAH1_HUMAN
A:
[35-302]
-
R
A
T
H
A
V
V
R
A
L
P
E
S
L
G
Q
-
H
--
A
L
R
S
---
A
K
-----------
G
---
E
E
V
D
V
A
R
A
E
R
Q
H
Q
L
Y
V
G
V
L
G
S
K
-
L
G
L
Q
V
V
E
L
P
A
D
E
-----
S
L
P
D
-------
C
V
F
V
E
D
V
A
V
V
C
E
E
T
A
L
I
T
R
P
G
A
P
S
R
R
K
E
V
D
M
M
K
E
A
L
E
K
L
Q
L
N
---------------------
I
V
E
M
---------------
K
D
E
N
A
T
L
D
G
G
D
V
L
F
T
G
R
E
F
F
V
G
L
S
K
R
T
N
Q
R
G
A
E
I
L
A
D
T
F
K
D
--
Y
A
V
S
T
V
P
V
--
A
D
G
L
H
L
K
S
F
C
S
M
A
G
P
N
L
I
A
I
G
S
---------
S
E
S
A
Q
-------
K
A
L
K
I
M
Q
Q
M
S
D
H
R
Y
D
K
L
T
V
P
-----
D
D
I
A
-------
A
N
C
I
Y
L
N
I
P
N
----
K
G
H
V
L
L
---
H
RTP
E
E
Y
P
E
S
A
K
V
Y
E
K
L
K
-
D
H
M
L
I
P
V
S
M
S
E
L
E
K
V
D
G
L
L
T
C
C
S
V
L
I
27
HHSearch
64.66
18%
-87
- C3 -
1JDW
1
GATM_HUMAN
A:
[74-412]
-
P
L
E
E
V
I
V
G
R
A
E
N
A
C
V
P
-
P
FT
I
E
-
V
K
A
N
T
Y
EKY
W
P
F
Y
Q
K
Q
G
G
HYF
P
K
D
H
L
K
K
A
V
A
E
I
E
E
M
C
N
I
L
K
-
T
-
E
G
V
T
V
R
R
P
D
P
I
D
WS
L
K
Y
K
T
P
D
F
E
S
T
G
L
Y
S
A
M
P
R
D
I
L
I
V
V
G
N
E
I
I
E
A
P
M
A
W
R
S
R
F
F
E
Y
R
A
Y
R
S
I
I
K
D
Y
F
H
R
G
A
K
W
T
T
A
PKPTMADELYNQDY
P
I
H
S
V
E
D
R
H
K
L
A
A
Q
GKFVT
T
E
F
E
P
C
F
D
A
A
D
F
I
R
A
G
R
D
I
F
A
Q
R
S
Q
V
T
N
Y
L
G
I
E
W
M
R
R
H
L
A
P
-
D
Y
R
V
H
I
I
S
F
K
D
P
N
P
M
H
I
D
A
T
F
N
I
I
G
P
G
I
V
L
S
N
P
---------
D
R
P
C
H
Q
I
-----
D
L
------
F
K
K
A
G
W
T
I
I
T
P
P
T
PIIP
D
D
H
P
LWMSSKW
L
S
M
N
V
L
M
L
-
D
----
E
K
R
V
M
V
---
D
---
A
N
E
V
P
I
Q
K
M
F
E
K
-
L
-
G
I
T
T
I
K
V
N
I
R
N
A
N
S
L
G
G
G
F
H
C
W
T
C
D
V