@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2475: (2016-02-08 )
MDDAFSEEGSAQPRHDAQRPALAPRSDGFDIHTYHPDFVADPYPLLRLIRSRAPVCRDQASIWWISRYADVSACLRDRRFSADPARLGAAGVRQGGASWFGHQQLQPLARFYDNFMLFNDAPRHTRLRRLFAPAFGPDAVRRWEARIEVLVEELLDSLLERREPDLLRDFAEPLTIRVAAELFGFPREDTGQLLPWGRDLAAGLDLAASHGDAGQINRSAVAFSDYLQRQARGWSDGSSRPPSGAAPSILDGAAMLEAGLGLEDLVAAYAMVFMAAFETTISMVGNATLALLTHPDQLDLLRRCPELAANAVEELLRFDGAVRGGVRCTLEEVEIGGQRIPPGEKVWLSFLAANRDPEMFAAPDRLQLQRANAKQHVAFAHGPHYCLGAYLARLELQCALRGLVRRRFALASEPTDLRWRRSSVFRTLERLPIVPEGDAQKTCE
Atome Classification :
(22 SA)
.........10........20........30........40........50......----.-----.60........70........80........90........---100.......110--........120.......130.......140...---....150.......160.--......170.......180.......190.......200.......210-........220----..-.....--230.......240.......250.......----260.......270.......280.......290.......300.......310.......320-....-...330.......340.......350.......360.......370.......380.......390.......400..--..---...410....---...420.......430.......440..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDDAFSEEGSAQPRHDAQRPALAPRSDG
F
D
I
H
TYHPDFVA
D
P
Y
P
L
L
R
L
I
R
SRAPVCR----D-----QA
S
I
W
W
I
S
R
Y
A
D
V
S
A
C
L
R
DRRFSA
D
P
A
RL
G
A
A
G
VRQG
G
A
SW---FG
H
Q
Q
L
Q
P
L
A
R
F
---
Y
D
N
F
M
LFNDA
P
R
H
T
R
L
R
R
L
FAPAF
G
P
D
A
V
R
R
W
E
A
---
R
I
E
V
L
V
E
E
L
L
D
S
L
L
E
RR
E
--
P
D
L
L
R
D
F
AEP
L
T
I
R
V
A
A
E
L
FGFPREDTGQLLPWG
R
D
L
A
AGL
D
L
AASHG--DAGQI
N
R
S
A
V
A
----
F
S
-
D
Y
L
Q
R
--
Q
ARGWSDGSSRPPSGAAPSIL
D
G
A
A
M
L
E
AG----L
G
L
E
D
L
V
A
A
Y
A
M
V
F
M
A
A
F
E
T
T
I
S
M
VGN
A
T
L
A
L
LTH
P
D
Q
L
D
L
L
R
R
C
P
E
L
A
A
N
A
V
E
E
L
L
R
FDGAV-RGG
V
-
R
C
T
L
E
EVEIGGQRIPP
G
E
K
V
W
L
S
F
L
AANRDPEMFAAP
D
R
L
Q
L
Q
RANAK
Q
H
V
A
FAHGP
H
Y
C
L
G
A
Y
L
A
R
L
E
L
Q
C
A
L
R
G
L
V
--
R
R
---
R
F
ALASEPT
D
---
L
R
W
R
R
S
S
V
F
R
T
L
E
RLPIVPEGDAQKTCE
16
PsiBlast_PDB
95.41
35%
-118
- C6 -
3BUJ
1
?
A:
[10-391]
------------------------------------
D
V
R
R
D
P
Y
P
S
Y
H
W
L
L
R
H
D
P
V
H
R
----
G
-----
A
H
R
V
W
Y
V
S
R
F
A
D
V
R
A
V
L
G
D
E
R
F
A
R
-------
T
G
I
R
R
F
W
T
D
L
---
V
G
P
G
L
L
---
A
E
I
---
V
G
D
I
I
L
F
Q
D
E
P
D
H
G
R
L
R
G
V
V
G
P
A
F
S
P
S
A
L
R
R
L
E
P
---
V
I
A
G
T
V
D
D
L
L
R
P
A
L
A
R
G
A
--
M
D
V
V
D
E
L
A
Y
P
L
A
L
R
A
V
L
G
L
L
G
L
P
A
A
D
W
G
A
V
G
R
W
S
R
D
V
G
R
T
L
D
R
G
A
S
A
E
--
D
M
R
R
G
H
A
A
I
A
E
----
F
A
-
D
Y
V
E
R
--
A
-------
L
A
R
R
R
R
E
G
G
E
D
L
L
--
A
L
M
L
D
A
H
D
R
GL
M
S
R
N
E
I
V
S
T
V
V
T
F
I
F
T
G
H
E
T
V
A
S
Q
V
G
N
A
V
L
S
L
L
A
H
P
D
Q
L
D
L
L
R
R
R
P
D
L
L
A
Q
A
V
E
E
C
L
R
Y
D
P
S
V
-
Q
S
N
T
-
R
Q
L
D
V
D
V
E
L
R
G
R
R
L
R
R
D
D
V
V
V
V
L
A
G
A
A
N
R
D
P
R
R
Y
D
R
P
D
D
F
D
I
E
R
-
D
P
V
P
S
M
S
F
G
A
G
M
R
Y
C
L
G
S
Y
L
A
R
T
Q
L
R
A
A
V
A
A
L
A
--
R
L
PGL
R
L
G
C
A
S
D
A
-----
L
A
Y
Q
P
R
T
M
F
R
G
L
A
S
L
P
I
-----------
126
HHSearch
94.46
35%
-104
- C6 -
3BUJ
1
?
A:
[9-397]
-----------------------------------
A
D
V
R
R
D
P
Y
P
S
Y
H
W
L
L
R
H
D
P
V
H
R
----
G
-----
A
H
R
V
W
Y
V
S
R
F
A
D
V
R
A
V
L
G
D
E
R
-
F
A
R
T
G
I
R
R
F
---------
W
---
T
D
L
V
G
P
G
L
L
A
E
I
---
V
G
D
I
I
L
F
Q
D
E
P
D
H
G
R
L
R
G
V
V
G
P
A
F
S
P
S
A
L
R
R
L
E
P
---
V
I
A
G
T
V
D
D
L
L
R
P
A
L
A
R
G
A
--
M
D
V
V
D
E
L
A
Y
P
L
A
L
R
A
V
L
G
L
L
G
L
P
A
A
D
W
G
A
V
G
R
W
S
R
D
V
G
R
T
L
D
R
G
A
S
A
E
--
D
M
R
R
G
H
A
A
I
A
E
----
F
A
-
D
Y
V
E
R
--
A
L
A
R
----
R
R
R
E
G
G
E
D
L
L
A
L
M
L
D
A
H
D
-
R
G
L
----
M
S
R
N
E
I
V
S
T
V
V
T
F
I
F
T
G
H
E
T
V
A
S
Q
V
G
N
A
V
L
S
L
L
A
H
P
D
Q
L
D
L
L
R
R
R
P
D
L
L
A
Q
A
V
E
E
C
L
R
Y
D
P
S
V
-
Q
S
N
T
-
R
Q
L
D
V
D
V
E
L
R
G
R
R
L
R
R
D
D
V
V
V
V
L
A
G
A
A
N
R
D
P
R
R
Y
D
R
P
D
D
F
D
I
E
R
D
P
-
V
P
S
M
S
F
G
A
G
M
R
Y
C
L
G
S
Y
L
A
R
T
Q
L
R
A
A
V
A
A
L
A
--
R
L
---
P
G
-
L
R
-
L
G
C
A
SDA
L
A
Y
Q
P
R
T
M
F
R
G
L
A
S
L
P
I
A
F
T
P
G
G
-----
26
PsiBlast_CBE
93.46
31%
-110
- C6 -
3EJD
3
BIOI_BACSU
D:
[6-394]
--------------------------------
T
A
S
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
----
G
S
F
L--
K
Y
P
G
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
K
V
R
T
P
L
P
E
S
S
T
---------------
K
Y
Q
D
L
S
H
V
---
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
---
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
K
K
K
--
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
--
A
L
T
E
G
N
I
M
A
V
Q
A
M
A
Y
F
K
-
E
L
I
Q
K
--
R
K
R
-------
H
P
Q
Q
D
M
I
S
M
L
L
K
G
R
E
--
K
------
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
T
-
Q
M
T
A
-
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
-
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
--
Q
R
---
M
P
S
L
N
L
A
D
-----
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
--------
27
PsiBlast_CBE
93.21
31%
-110
- C6 -
3EJB
3
BIOI_BACSU
H:
[6-393]
--------------------------------
T
A
S
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
----
G
SFL--
K
Y
P
G
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
K
V
R
T
P
L
P
E
S
S
T
---------------
K
Y
Q
D
L
S
H
V
---
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
---
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
K
K
K
--
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
--
A
L
T
E
G
N
I
M
A
V
Q
AMAY
F
K
-
E
L
I
Q
K
--
R
K
R
-------
H
P
Q
Q
D
M
I
S
M
L
L
K
G
R
E
--
K
D
K
----
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
T
-
Q
M
T
A
-
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
-
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
--
Q
R
---
M
P
S
L
N
L
A
D
-
E
---
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
---------
36
PsiBlast_CBE
93.17
34%
-117
- C6 -
3A50
5
CPVDH_PSEAH
C:
[18-397]
-------------------------------------
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
LAL-
P
-----
D
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
---------------
W
RHR
L
P
E
D
Q
R
A
D
M
P
A
T
---
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
---
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
D
G
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
---
V
D
D
S
P
A
D
D
--
K
N
A
A
M
G
K
L
H
G
Y
----
L
S
-
D
L
L
E
R
--
K
-------
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
M
D
G
D
R
----
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
---
E
L
A
L
A
V
G
L
D
E
---
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
----------
29
PsiBlast_CBE
92.99
31%
-106
- C6 -
3EJB
3
BIOI_BACSU
D:
[6-394]
--------------------------------
T
A
S
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
----
G
S
F
L--
K
Y
P
G
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
K
V
R
T
P
L
P
E
S
S
T
---------------
K
Y
Q
D
L
S
H
V
---
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
---
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
K
K
K
--
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
--
A
L
T
E
G
N
I
M
A
V
Q
A
M
A
Y
F
K
-
E
L
I
Q
K
--
R
K
R
-------
H
P
Q
Q
D
M
I
S
M
L
L
K
G
R
E
--
K
D
K
----
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
T
-
Q
M
T
A
-
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
-
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
--
Q
R
---
M
P
S
L
N
L
A
------
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
--------
37
PsiBlast_CBE
92.93
34%
-117
- C6 -
3A50
2
CPVDH_PSEAH
B:
[18-397]
-------------------------------------
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
LAL-
P
-----
D
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
---------------
W
RHR
L
P
E
D
Q
R
A
D
M
P
A
T
---
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
---
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
D
G
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
---
V
D
D
S
P
A
D
D
--
K
N
A
A
M
G
K
L
H
G
Y
----
L
S
-
D
L
L
E
R
--
K
-------
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
M
D
G
D
R
----
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
---
E
L
A
L
A
V
G
L
D
E
---
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
----------
6
PsiBlast_PDB
92.92
34%
-116
- C6 -
3A51
8
CPVDH_PSEAH
A:
[18-397]
-------------------------------------
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
LAL-
P
-----
D
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
---------------
W
RHR
L
P
E
D
Q
R
A
D
M
P
A
T
---
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
---
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
D
G
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
---
V
D
D
S
P
A
D
D
--
K
N
A
A
M
G
K
L
H
G
Y
----
L
S
-
D
L
L
E
R
--
K
-------
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
M
D
G
D
R
----
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
---
E
L
A
L
A
V
G
L
D
E
---
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
----------
32
PsiBlast_CBE
92.81
34%
-117
- C6 -
3A51
5
CPVDH_PSEAH
C:
[18-397]
-------------------------------------
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
LAL-
P
-----
D
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
---------------
W
RHR
L
P
E
D
Q
R
A
D
M
P
A
T
---
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
---
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
D
G
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
---
V
D
D
S
P
A
D
D
--
K
N
A
A
M
G
K
L
H
G
Y
----
L
S
-
D
L
L
E
R
--
K
-------
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
M
D
G
D
R
----
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
---
E
L
A
L
A
V
G
L
D
E
---
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
----------
31
PsiBlast_CBE
92.81
34%
-115
- C6 -
3A51
6
CPVDH_PSEAH
D:
[18-397]
-------------------------------------
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
LAL-
P
-----
D
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
---------------
W
RHR
L
P
E
D
Q
R
A
D
M
P
A
T
---
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
---
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
D
G
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
---
V
D
D
S
P
A
D
D
--
K
N
A
A
M
G
K
L
H
G
Y
----
L
S
-
D
L
L
E
R
--
K
-------
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
M
D
G
D
R
----
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
---
E
L
A
L
A
V
G
L
D
E
---
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
----------
35
PsiBlast_CBE
92.76
34%
-116
- C6 -
3A50
6
CPVDH_PSEAH
D:
[18-397]
-------------------------------------
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
LAL-
P
-----
D
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
---------------
W
RHR
L
P
E
D
Q
R
A
D
M
P
A
T
---
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
---
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
D
G
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
---
V
D
D
S
P
A
D
D
--
K
N
A
A
M
G
K
L
H
G
Y
----
L
S
-
D
L
L
E
R
--
K
-------
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
M
D
G
D
R
----
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
---
E
L
A
L
A
V
G
L
D
E
---
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
----------
3
PsiBlast_PDB
92.71
31%
-112
- C6 -
3EJE
3
BIOI_BACSU
B:
[9-394]
-----------------------------------
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
----
G
S
F
L--
K
Y
P
G
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
K
V
R
T
P
L
P
E
S
S
T
---------------
K
Y
Q
D
L
S
H
V
---
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
---
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
K
K
K
--
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
--
A
L
T
E
G
N
I
M
A
V
Q
A
M
A
Y
F
K
-
E
L
I
Q
K
--
R
K
R
-------
H
P
Q
Q
D
M
I
S
M
L
L
K
-------
K
----
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
T
-
Q
M
T
A
-
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
-
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
--
Q
R
---
M
P
S
L
N
L
A
------
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
--------
33
PsiBlast_CBE
92.66
34%
-118
- C6 -
3A51
3
CPVDH_PSEAH
B:
[18-397]
-------------------------------------
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
LAL-
P
-----
D
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
---------------
W
RHR
L
P
E
D
Q
R
A
D
M
P
A
T
---
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
---
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
D
G
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
---
V
D
D
S
P
A
D
D
--
K
N
A
A
M
G
K
L
H
G
Y
----
L
S
-
D
L
L
E
R
--
K
-------
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
M
D
G
D
R
----
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
---
E
L
A
L
A
V
G
L
D
E
---
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
----------
4
PsiBlast_PDB
92.62
34%
-116
- C6 -
3A4Z
7
CPVDH_PSEAH
A:
[18-397]
-------------------------------------
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
AL-
P
-----
D
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
---------------
W
RHR
L
P
E
D
Q
R
A
D
M
P
A
T
---
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
---
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
D
G
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
---
V
D
D
S
P
A
D
D
--
K
N
A
A
M
G
K
L
H
G
Y
----
L
S
-
D
L
L
E
R
--
K
-------
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
M
D
G
D
R
----
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
---
E
L
A
L
A
V
G
L
D
E
---
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
----------
82
PsiBlast_CBE
92.53
32%
-102
- C6 -
1OXA
2
CPXJ_SACEN
A:
[10-403]
--------------------------------
S
F
H
V
D
W
Y
S
T
-
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
----
L
-----
G
Q
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
S
S
D
P
K
K
-
K
Y
P
G
V
E
V
E
F
P
A
Y
---
L
G
F
P
E
--
D
V
R
N
Y
---
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
---
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
G
D
S
G
V
--
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
A
A
R
G
A
F
G
R
W
S
S
E
I
L
V
M
D
P
E
R
A
E
Q
----
R
G
Q
A
A
R
E
V
V
N
----
F
I
L
D
L
V
E
R
--
R
-------
R
T
E
P
G
D
D
L
L
S
A
L
I
S
V
Q
D
D
D
D
G
R
----
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
A
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
-
E
T
T
T
-
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
S
Q
F
P
D
P
H
R
F
D
V
T
R
-
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
--
G
R
F
P
-
A
L
S
L
G
I
D
A
D
D
---
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
L
D
G
-------
5
PsiBlast_PDB
92.47
34%
-116
- C6 -
3A50
8
CPVDH_PSEAH
A:
[18-397]
-------------------------------------
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
LAL-
P
-----
D
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
---------------
W
RHR
L
P
E
D
Q
R
A
D
M
P
A
T
---
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
---
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
D
G
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
---
V
D
D
S
P
A
D
D
--
K
N
A
A
M
G
K
L
H
G
Y
----
L
S
-
D
L
L
E
R
--
K
-------
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
M
D
G
D
R
----
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
---
E
L
A
L
A
V
G
L
D
E
---
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
----------
83
PsiBlast_CBE
92.44
32%
-100
- C6 -
1JIN
2
CPXJ_SACEN
A:
[10-403]
--------------------------------
S
F
H
V
D
W
Y
S
T
-
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
----
L
-----
G
Q
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
S
S
D
P
K
K
-
K
Y
P
G
V
E
V
E
F
P
A
Y
---
L
G
F
P
E
--
D
V
R
N
Y
---
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
---
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
G
D
S
G
V
--
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
A
A
R
G
A
F
G
R
W
S
S
E
I
L
V
M
D
P
E
R
A
E
Q
----
R
G
Q
A
A
R
E
V
V
N
----
F
I
L
D
L
V
E
R
--
R
-------
R
T
E
P
G
D
D
L
L
S
A
L
I
S
V
Q
D
D
D
D
G
R
----
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
A
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
-
E
T
T
T
-
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
S
Q
F
P
D
P
H
R
F
D
V
T
R
-
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
--
G
R
F
P
-
A
L
S
L
G
I
D
A
D
D
---
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
L
D
G
-------
21
PsiBlast_CBE
92.35
31%
-111
- C6 -
3EJE
3
BIOI_BACSU
H:
[6-394]
--------------------------------
T
A
S
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
----
G
SFL--
K
Y
P
G
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
K
V
R
T
P
L
P
E
S
S
T
---------------
K
Y
Q
D
L
S
H
V
---
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
---
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
K
K
K
--
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
--
A
L
T
E
G
N
I
M
A
V
Q
AMAY
F
K
-
E
L
I
Q
K
--
R
K
R
-------
H
P
Q
Q
D
M
I
S
M
L
L
K
-----
K
D
K
----
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
T
-
Q
M
T
A
-
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
-
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
--
Q
R
---
M
P
S
L
N
L
A
------
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
--------
24
PsiBlast_CBE
92.33
31%
-113
- C6 -
3EJD
3
BIOI_BACSU
H:
[7-393]
---------------------------------
A
S
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
----
G
SFL--
K
Y
P
G
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
K
V
R
T
P
L
P
E
S
S
T
---------------
K
Y
Q
D
L
S
H
V
---
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
---
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
K
K
K
--
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
--
A
L
T
E
G
N
I
M
A
V
Q
AMAY
F
K
-
E
L
I
Q
K
--
R
K
R
-------
H
P
Q
Q
D
M
I
S
M
L
L
K
G
-----
D
K
----
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
T
-
Q
M
T
A
-
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
-
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
--
Q
R
---
M
P
S
L
N
L
A
D
-----
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
---------
25
PsiBlast_CBE
92.18
31%
-112
- C6 -
3EJD
4
BIOI_BACSU
F:
[9-394]
-----------------------------------
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
----
G
S
F
L--
K
Y
P
G
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
K
V
R
T
P
L
P
E
S
S
T
---------------
K
Y
Q
D
L
S
H
V
---
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
---
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
K
K
K
--
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
--
A
L
T
E
G
N
I
M
A
V
Q
A
M
A
Y
F
K
-
E
L
I
Q
K
--
R
K
R
-------
H
P
Q
Q
D
M
I
S
M
L
L
K
G
R
----
D
K
----
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
T
-
Q
M
T
A
-
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
-
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
--
Q
R
---
M
P
S
L
N
L
A
------
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
--------
66
PsiBlast_CBE
87.66
32%
-111
- C6 -
3ZPI
13
PIKC_STRVZ
A:
[35-423]
----------------------------
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
E
-----
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
---------------
W
-----
R
N
S
T
T
P
L
T
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
---
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
GR
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
-------
T
D
A
F
V
F
P
D
--
D
P
A
Q
A
Q
T
A
M
A
E
----
M
S
-
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
D
G
S
R
L
T
S
---------
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
-
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
--
E
R
C
P
-
D
L
A
L
D
V
S
P
G
E
---
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
-----------
88
PsiBlast_CBE
87.13
33%
-103
- C6 -
2Z3U
8
?
A:
[9-382]
----------------------------
F
D
L
M
G
W
D
K
K
D
I
A
D
P
Y
P
V
Y
R
R
Y
R
E
A
A
P
V
H
R
----
T
A
S
G
P
G
K
P
D
T
Y
Y
V
F
T
Y
D
D
V
V
R
V
L
S
N
R
R
L
G
R
N
-
A
R
V
A
S
G
D
T
D
T
A
P
V
P
I
P--
T
E
H
R
A
L
R
T
V
V
------
E
N
W
L
V
F
L
D
P
P
H
H
T
E
L
R
S
L
L
T
T
E
F
S
P
S
I
V
T
G
L
R
P
---
R
I
A
E
L
A
S
A
L
L
D
R
L
R
A
Q
R
R
--
P
D
L
V
E
G
F
A
A
P
L
P
I
L
V
I
S
A
L
L
G
I
P
E
E
D
H
T
----
W
L
R
A
N
A
V
A
L
Q
E
A
S
T
T
R
AR
D
G
R
G
Y
A
R
A
E
A
A
S
Q
E
-
F
T
-
R
Y
F
R
R
--
E
V
D
R
R
G
G
D
D
R
D
D
L
L
T
L
L
V
R
A
R
D
T
G
S
----
P
----
L
S
V
D
G
I
V
G
T
C
V
H
L
L
T
A
G
H
E
T
T
T
N
F
L
A
K
A
V
L
T
L
R
A
H
R
D
V
L
D
E
L
R
T
T
P
E
S
T
P
A
A
V
E
E
L
M
R
Y
D
P
P
V
-
Q
A
V
T
-
R
W
A
Y
E
D
I
R
L
G
D
H
D
I
P
R
G
S
R
V
V
A
L
L
G
S
A
N
R
D
P
A
R
F
P
D
P
D
V
L
D
V
H
R
A
-
A
E
R
Q
V
G
F
G
L
G
I
H
Y
C
L
G
A
T
L
A
R
A
E
A
E
I
G
L
R
A
L
L
------------------------------------------------