@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2555: (2016-02-08 )
MRDYATTAAGFDLQRTAAATLSGTLQALNACVECCDRHALPGRIALFWEGKDGSRASYTFSELKALSGRFANFLQAQGVRPGDCVAGLLPRTPELLVTILGAWRLGAVYQPLFTAFGPKAIEHRVATAGSKVLVTDAANRDKLDELADPPLAVTVGGPKGQGIRRGDFSFWAELERYPAEFEPVPRSGEDPFLMMFTSGTTGLAKPVPVPLKAILAFVGYLREAVDLRPEDAFWNLADPGWAYGLYYAVAGPLAMGHPTTFYEGPFSVESTCRIIRDYGITNLAGSPTAYRLLMAAGAAAETALKGRLRAVSSAGEPLTPEVIRWFADRLGTTIHDHYGQTELGMVLCNHHALAHPVRVGAAGFACPGHRVVVLDDDLNELPPGQPGILALDRRRSPLMWFPGYQGLETAAFVGDYYLSGDTVELNEDGSISFVGRADDVITTSGYRVGPFDVESALIEHPAVMEAAVIGKPDPERTELVKAFVVLCAGHRPTPELADALQRYVRQRLSAHAYPREIEFLEELPKTPSGKIQRFLLRNQEIARQREAAPRAAAAN
Atome Classification :
(30 SA)
-------------------------------.........10........20....-.------------...30........40-----.--.--.......50.-......-.60........70....-....80........90........100.......110.......120.......130...-...----------.140------.----....----.---------------...150------..----......-.160...--...-----------...170..-....----.180----.......190.......200.......210.-......220-....-....230.......240.......250.......260-.-..---....270-...---......280.......290.....-..-300...-.....310.......320.......330-.---..---......340.......350.-......360.......370.....-------------..380.........390..-.-.--..---.--400..----...--..---410--..--.--......420.......430.......440.......450.......460.......470.......480......---.490-........500.-------......510.......520.......530.......540.......550...---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------MRDYATTAAGFD
L
Q
R
T
A
A
A
T
L
S
G
T
L
-
Q
------------
A
L
N
A
C
V
E
C
C
D
RHAL------P--G--
R
I
A
L
F
W
EGKD-GSRAS
Y
-
T
F
S
E
L
K
A
L
S
G
R
F
A
N
F
L
Q
-AQGVR
P
G
D
C
V
A
G
LLPR
T
P
E
L
L
V
T
I
L
G
A
W
R
L
G
A
V
Y
Q
P
L
F
T
AF
G
P
K
A
I
E
H
R
V
ATAG
S
K
V
L
V
T-DAA----------
N
R
--------
D
----
K
L
D
E
----L---------------ADP
P
--------
L
A
----
V
T
VGGP-KG--QGI--RRG-----------
D
F
S
F
W
A
E
L
-
E
RYP----AEFE----PVPRSGED
P
F
L
M
M
FTSGTTGLAKPVPV
P
L
K
A
-
I
L
A
F
V
G
Y
-
L
-
R
E
A
V-DLRPEDAFWNLADPG
W
A
Y
G
L
Y
Y
AVAGPLAMGHPTTFY-E-GP---F
S
V
E
S
---
T
C
R
---
I
I
R
D
YGITNLAGS
P
T
A
Y
R
L
L
M
AAG-
A
A
-
A
-
E
T
A
L
-
K
G
R
L
R
A
VSSAGEPL
T
P
E
V
I
R
W
F
A
D
R
L---G---
T
T
---
I
H
DHYGQ
T
E
L
G
M
V
LCNHHAL-AH
P
V
RVGAAGFACPG
H
R
V
V
V
LDD
D
-------------
L
N
E--LPPGQP
G
I
L
A
L
DRR-R-S--P
L
---
M
--WFPGY----QGL--
E
T
---
A
----
A
F
--
V
--
G
D
Y
YLSG
D
T
V
E
LNEDG
S
I
S
F
VGRAD
D
V
I
TTSG
Y
R
VG
P
F
D
V
E
S
A
L
IEHP
A
V
M
E
A
AVIGKPD
P
E
R
T
E
L
V
K
A
F
V
V
L
CA---GHR--P
T
P
E
L
A
D
A
L
Q
R
Y
-------
V
R
Q
R
L
S
AHAYP
R
E
I
E
F
L
E
ELPKTP
S
G
K
I
Q
R
F
L
L
R
N
Q
E
I
A
R
Q
R
EAAPRAAAAN---
1
PsiBlast_PDB
94.45
31%
-88
- C4 -
2P2B
2
ACSA_SALTY
A:
[75-627]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
G
V
R
AG
R
S
I
P
L
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVE
H
V
I
V
L
K
R
-
T
G
--
S
D
I
D
W
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PA
R
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
A
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
ATE
G
N
L
V
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
21
PsiBlast_CBE
93.99
31%
-89
- C4 -
2P2B
2
ACSA_SALTY
B:
[75-621]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
GVRAGRSIPL
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVEH
V
I
V
L
K
R
-
T
G
--
S
D
I
DW
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PAR
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
A
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
KCP
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
GHPQEGATEGNLV
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
25
PsiBlast_CBE
93.92
31%
-88
- C4 -
2P2J
2
ACSA_SALTY
B:
[75-626]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
GVRAGRSIPL
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVEH
V
I
V
L
K
R
-
T
G
--
S
D
I
DW
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PAR
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
KCP
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
GHPQEGATEGNLV
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
A
I
M
R
R
I
L
R
K
--------------------
26
PsiBlast_CBE
93.57
31%
-90
- C4 -
2P20
1
ACSA_SALTY
B:
[75-625]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
G
V
R
AGRSIP
L
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVE
H
V
I
V
L
K
R
-
T
G
--
S
D
I
D
W
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PA
R
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
GHPQEGATE
G
N
L
V
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
A
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
24
PsiBlast_CBE
93.46
31%
-88
- C4 -
2P2Q
1
ACSA_SALTY
B:
[75-625]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
G
V
R
AGRSIP
L
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVE
H
V
I
V
L
K
R
-
T
G
--
S
D
I
D
W
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PA
R
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
GHPQEGATE
G
N
L
V
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
E
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
23
PsiBlast_CBE
93.45
31%
-90
- C4 -
2P2F
3
ACSA_SALTY
B:
[75-628]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
G
V
R
AGRSIP
L
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVE
H
V
I
V
L
K
R
-
T
G
--
S
D
I
D
W
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PA
R
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
ATE
G
N
L
V
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
5
PsiBlast_PDB
93.22
31%
-89
- C4 -
2P2J
2
ACSA_SALTY
A:
[75-627]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
G
V
R
AGRSIP
L
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVE
H
V
I
V
L
K
R
-
T
G
--
S
D
I
D
W
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PA
R
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
ATE
G
N
L
V
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
A
I
M
R
R
I
L
R
K
--------------------
6
PsiBlast_PDB
93.12
31%
-89
- C4 -
2P20
1
ACSA_SALTY
A:
[75-619]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
G
V
R
AGRSIP
L
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVE
H
V
I
V
L
K
R
-
T
G
--
S
D
I
D
W
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PA
R
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
GHPQEGATE
G
N
L
V
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
A
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
22
PsiBlast_CBE
93.03
31%
-87
- C4 -
2P2M
1
ACSA_SALTY
B:
[75-627]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
GVRAGASIPL
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVEH
V
I
V
L
K
R
-
T
G
--
S
D
I
DW
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PAR
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
KCP
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
GHPQEGATEGNLV
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
4
PsiBlast_PDB
93.03
31%
-89
- C4 -
2P2Q
1
ACSA_SALTY
A:
[75-625]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
G
V
R
AGRSIP
L
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVE
H
V
I
V
L
K
R
-
T
G
--
S
D
I
D
W
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PA
R
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
ATE
G
N
L
V
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
E
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
2
PsiBlast_PDB
92.99
31%
-89
- C4 -
2P2M
1
ACSA_SALTY
A:
[75-622]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
G
V
R
AGASIP
L
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVE
H
V
I
V
L
K
R
-
T
G
--
S
D
I
D
W
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PA
R
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
ATE
G
N
L
V
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
3
PsiBlast_PDB
92.96
31%
-90
- C4 -
2P2F
3
ACSA_SALTY
A:
[75-622]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
G
V
R
AGRSIP
L
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVE
H
V
I
V
L
K
R
-
T
G
--
S
D
I
D
W
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PA
R
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
ATE
G
N
L
V
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
8
PsiBlast_PDB
92.94
31%
-87
- C4 -
1PG4
7
ACSA_SALTY
A:
[75-627]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
G
V
R
AG
R
S
I
P
L
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVE
H
V
I
V
L
K
R
-
T
G
--
S
D
I
D
W
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PA
R
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
ATE
G
N
L
V
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
7
PsiBlast_PDB
92.92
31%
-89
- C4 -
1PG3
5
ACSA_SALTY
A:
[75-626]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
G
V
R
AG
R
S
I
P
L
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVE
H
V
I
V
L
K
R
-
T
G
--
S
D
I
D
W
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PA
R
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
ATE
G
N
L
V
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
27
PsiBlast_CBE
92.83
31%
-87
- C4 -
1PG4
6
ACSA_SALTY
B:
[75-621]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
GVRAGRSIPL
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVEH
V
I
V
L
K
R
-
T
G
--
S
D
I
DW
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PAR
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
KCP
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
GHPQEGATEGNLV
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
35
PsiBlast_CBE
92.56
31%
-104
- C4 -
3ETC
10
?
B:
[53-562]
---------------------------------------------------------
E
------------
N
F
N
F
A
Y
D
V
V
D
V
Y
A
R
DS----
P
--
E
--
K
L
A
M
I
W
C
D
D
Y
-
G
N
E
K
I
F
-
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
-
I
A
E
----------
D
D
V
P
------
E
----
Q
V
D
E
A
H
A
E
C
---------------
G
D
I
P
--------
L
K
K
---
A
K
V
G
G
-------
D
V
--
L
E
G
-----------
W
I
D
F
R
K
E
L
-
E
E
S
S
----
P
I
F
E
RPTG
E
V
S
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
-
P
L
G
H
I
L
T
-
A
-
K
Y
W
Q
-
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
Y
-
D
Y
D
R
---
F
E
A
K
N
---
M
L
E
---
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
F
L
I
K
E
D
-
L
S
-
H
-
Y
N
F
---
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
---
G
---
I
K
---
L
M
E
G
F
G
Q
T
E
T
V
V
T
I
A
T
F
P
W
M
-
E
P
--
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
-------------
G
R
L
--
C
E
V
G
E
E
G
E
I
V
I
N
T
M
-
E
G
K
--
P
V
---
G
--
L
F
V
H
Y
GKD
P
E
R
T
--
E
E
---
T
----
W
H
--
D
--
G
-
Y
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
---
D
Y
T
--
P
S
D
S
L
K
N
E
L
Q
D
H
-------
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
L
P
K
---------------------------------
28
PsiBlast_CBE
92.38
31%
-88
- C4 -
1PG3
6
ACSA_SALTY
B:
[75-621]
-----------------------------------------------------------------------
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
-
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
GVRAGRSIPL
K
K
--------
N
----
V
D
D
A
----
L
---------------
K
N
P
N
--------
V
T
SVEH
V
I
V
L
K
R
-
T
G
--
S
D
I
DW
Q
E
G
-----------
R
D
L
W
W
R
D
L
I
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
-
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
PAR
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
-
I
-
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
---
K
E
KCP
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
GHPQEGATEGNLV
I
T
D
--
S
W
P
G
Q
A
R
T
L
F
G
D
H
E
-
R
-
F
--
E
Q
---
T
--
Y
F
S
T
F
----
K
N
M
----------------------
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
69
Fugue
92.02
29%
-86
- C4 -
1PG4
7
ACSA_SALTY
A:
[5-647]
HKHAIP
A
N
I
A
D
RCLIN
P
E
Q
Y
E
T
K
Y
K
Q
S
I
N
D
P
D
T
F
W
G
E
Q
G
K
I
L
D
W
I
T
P
Y
Q
K
V
K
N
T
S
F
-
A
PG
N
V
S
I
K
W
YED
G
T
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
NG
D
--
R
T
A
I
I
W
E
G
D
D
T
S
Q
S
K
H
I
-
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
----------
V
R
AG
R
S
I
P
L
K
K
----
N
V
D
D
----
A
---------------
L
K
N
P
NVTSVE
H
V
I
V
----
L
K
R
T
G
S
-
D
I
--
D
W
Q
--
E
G
R
-----------
D
L
W
W
R
D
L
I
-
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
-
T
-
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
W
P
T
---
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
-
D
K
-
A
-
I
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
KEK
C
P
---
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
-------------
G
H
P
--
Q
E
G
A
T
E
G
N
L
V
I
T
D
S
-
W
-
P
--
G
Q
---
A
RT
L
F
G
D
H
----
E
R
F
--
E
Q
---
T
----
Y
F
ST
F
--
K
N
M
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
I
A
A
G
D
A
D
P
G
V
V
E
K
L
L
E
E
K
Q
A
43
HHSearch
92.01
31%
-85
- C4 -
1PG4
7
ACSA_SALTY
A:
[67-632]
---------------------------------------------------
I
K
W
Y
E
D
G
------------
T
L
N
L
A
A
N
C
L
D
R
H
L
Q
------
E
NG
D
--
R
T
A
I
I
W
E
G
D
D
T
S
Q
S
K
H
I
-
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
-
A
D
E
----------
G
V
--------
R
----
A
G
R
S
----
I
P
L
K
K
N
V
D
D
A
L
K
NPNV
T
S
V
E
--------
H
V
----
I
V
L
K
R
T
-
G
S
D
I
D
W
Q
--
E
G
R
-----------
D
L
W
W
R
D
L
I
-
E
K
A
S
----
P
E
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
-
T
F
K
Y
V
F
-
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
PNW
P
T
P
A
R
---
M
C
Q
---
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
-
D
K
-
A
I
E
G
T
D
-
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
GKE
K
---
C
P
---
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
-
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
-------------
G
H
P
--
Q
E
G
A
T
E
G
N
L
V
I
T
D
--
S
-
W
--
P
----
G
--
Q
A
R
T
L
----
F
G
D
--
H
E
---
R
F
E
Q
T
Y
F
--
S
TF
K
N
M
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
---
G
E
E
--
P
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
I
A
A
G
D
---------------
30
PsiBlast_CBE
91.80
33%
-93
- C4 -
2WD9
2
ACS2A_HUMAN
B:
[61-560]
--------------------------------------------------------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
-
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
-
G
D
E
----------
V
I
--------
Q
----
E
V
D
T
----
V
---------------
A
S
E
C
--------
P
S
----
L
R
I
K
L
L
-
V
S
--
E
K
S
--
C
D
G
-----------
W
L
N
F
K
K
L
L
-
N
E
A
S
----
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
M
-
D
-
A
G
W
T
-
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
-
L
P
K--
F
D
P
L
V
---
I
L
K
---
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
-
L
S
-
S
-
Y
K
F
---
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
-
K
--
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
-------------
G
N
V
--
L
P
P
G
T
E
G
D
I
G
I
R
V
K
P
I
-
R
--
P
I
---
G
--
I
F
S
G
Y
----
V
D
N
P
D
K
T
---
A
----
A
N
--
I
R-
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
QFL
S
H
D
--
P
E
-
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------------
14
PsiBlast_PDB
91.78
33%
-91
- C4 -
3EQ6
2
ACS2A_HUMAN
A:
[61-560]
--------------------------------------------------------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
-
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
-
G
D
E
----------
V
I
--------
Q
----
E
V
D
T
----
V
---------------
A
S
E
C
--------
P
S
----
L
R
I
K
L
L
-
V
S
--
E
K
S
--
C
D
G
-----------
W
L
N
F
K
K
L
L
-
N
E
A
S
----
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
M
-
D
-
A
G
W
T
-
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
-
L
P
K--
F
D
P
L
V
---
I
L
K
---
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
-
L
S
-
S
-
Y
K
F
---
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
-
K
--
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
-------------
G
N
V
--
L
P
P
G
T
E
G
D
I
G
I
R
V
K
P
I
-
R
--
P
I
---
G
--
I
F
S
G
Y
----
V
D
N
P
D
K
T
---
A
----
A
N
--
I
R-
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
QFL
S
H
D
--
P
E
-
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------------
45
HHSearch
91.53
32%
-100
- C4 -
3C5E
7
ACS2A_HUMAN
A:
[35-562]
---------------------------------------------------------
A
------------
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
GK
R
P-
P
--
S
P
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
-
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
-
G
D
E
----------
V
I
--------
Q
----
E
V
D
T
V
ASE
C
---------------
P
S
L
R
--------
I
K
----
L
L
V
S
E
K
-------
S
--
C
D
G
-----------
W
L
N
F
K
K
L
L
-
N
E
A
S
----
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
M
-
D
-
A
G
W
T
-
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
L
-
P
K
---
F
D
P
L
V
---
I
L
K
---
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
-
L
S
----
S
Y
K
-
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
---
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
-------------
G
N
V
--
L
P
P
G
T
E
G
D
I
G
I
R
V
K
-
P
-
I
R
P
I
----
G
--
I
F
S
G
Y
----
V
D
N
--
P
D
K
T
A
A
----
N
I
--
R
--
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
---
Q
F
L
SH
D
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
----------------
32
PsiBlast_CBE
91.41
33%
-91
- C4 -
3EQ6
2
ACS2A_HUMAN
B:
[61-560]
--------------------------------------------------------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
-
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
-
G
D
E
----------
V
I
--------
Q
----
E
V
D
T
----
V
---------------
A
S
E
C
--------
P
S
----
L
R
I
K
L
L
-
V
S
--
E
K
S
--
C
D
G
-----------
W
L
N
F
K
K
L
L
-
N
E
A
S
----
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
M
-
D
-
A
G
W
T
-
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
-
L
P
K--
F
D
P
L
V
---
I
L
K
---
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
-
L
S
-
S
-
Y
K
F
---
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
-
K
--
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
-------------
G
N
V
--
L
P
P
G
T
E
G
D
I
G
I
R
V
K
P
I
-
R
--
P
I
---
G
--
I
F
S
G
Y
----
V
D
N
PD
K
T
---
A
----
A
N
--
I
R-
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
QFL
S
H
D
--
P
E
-
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------------
17
PsiBlast_PDB
91.33
33%
-87
- C4 -
1RY2
1
ACS1_YEAST
A:
[81-646]
-----------------------------------------------------------------------
L
N
A
C
Y
N
C
V
D
R
H
A
L
K
T----
P
--
N
--
K
K
A
I
I
F
E
G
D
E
P
G
Q
G
Y
S
I
-
T
Y
K
E
L
L
E
E
V
C
Q
V
A
Q
V
L
T
Y
S
M
G
V
R
K
G
D
T
V
A
V
Y
M
P
M
V
P
E
A
I
I
T
L
L
A
I
S
R
I
G
A
I
H
S
V
V
F
A
G
F
S
S
N
S
L
R
D
R
I
N
D
G
D
S
K
V
V
I
T
T
D
E
S
----------
N
R
--------
G
G
K
V
I
E
T
K
R
----
I
---------------
V
D
D
A
--------
L
R
----
E
T
P
G
V
R
-
H
V
--
L
V
Y
--
R
K
T
NNPS
V
A
F
H
A
PR
D
L
D
W
A
T
E
K
-
K
K
Y
K
----
T
Y
Y
P
----
C
T
P
V
D
S
E
D
P
L
F
L
L
Y
T
S
G
S
T
G
A
P
K
G
V
Q
H
S
T
A
G
Y
L
L
G
A
L
L
T
-
M
-
R
Y
T
F
-
D
T
H
Q
E
D
V
F
F
T
A
G
D
I
G
W
I
T
G
H
T
Y
V
V
Y
G
P
L
L
Y
G
C
A
T
L
V
F
-
E
-
G
T
---
P
A
Y
P
N
---
Y
S
R
Y
W
D
I
I
D
E
H
K
V
T
Q
F
Y
V
A
P
T
A
L
R
L
L
K
R
A
G
-
D
S
Y
I
-
E
N
H
S
-
L
K
S
L
R
C
L
G
S
V
G
E
P
I
A
A
E
V
W
E
W
Y
S
E
K
I
---
G
---
K
N
E
I
P
I
V
D
T
Y
W
Q
T
E
S
G
S
H
L
V
T
P
L
A
G
G
V
T
P
M
K
P
G
S
A
S
F
P
F
F
G
I
D
A
V
V
L
D
P
N
-------------
T
G
E
E
L
N
T
S
H
A
E
G
V
L
A
V
K
A
A
-
W
-
P
--
S
F
ART
I
--
W
K
N
H
D
----
R
Y
L
--
D
T
YL-
N
----
P
Y
--
P
--
G
-
Y
Y
F
T
G
D
G
A
A
K
D
K
D
G
Y
I
W
I
L
G
R
V
D
D
V
V
N
V
S
G
H
R
L
S
T
A
E
I
E
A
A
I
I
E
D
P
I
V
A
E
C
A
V
V
G
F
N
D
D
L
T
G
Q
A
V
A
A
F
V
V
L
K
-----------------
L
Q
D
I
K
K
H
L
V
F
T
V
R
K
D
I
G
P
F
A
A
P
K
L
I
I
L
V
D
D
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
--------------------
12
PsiBlast_PDB
91.11
33%
-95
- C4 -
3DAY
18
ACS2A_HUMAN
A:
[61-560]
--------------------------------------------------------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
-
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
-
G
D
E
----------
V
I
--------
Q
----
E
V
D
T
----
V
---------------
A
S
E
C
--------
P
S
----
L
R
I
K
L
L
-
V
S
--
E
K
S
--
C
D
G
-----------
W
L
N
F
K
K
L
L
-
N
E
A
S
----
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
M
-
D
-
A
G
W
T
-
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
-
L
P
K--
F
D
P
L
V
---
I
L
K
---
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
-
L
S
-
S
-
Y
K
F
---
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
-
K
--
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
-------------
G
N
V
--
L
P
P
G
T
E
G
D
I
G
I
R
V
K
P
I
-
R
--
P
I
---
G
--
I
F
S
G
Y
----
V
D
N
P
D
K
T
---
A
----
A
N
--
I
R-
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
--
R
G
E
V
V
K
A
F
V
V
L
A
S
QFL
S
H
D
--
P
E
-
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------------
16
PsiBlast_PDB
91.00
31%
-106
- C4 -
3ETC
11
?
A:
[53-559]
---------------------------------------------------------
E
------------
N
F
N
F
A
Y
D
V
V
D
V
Y
A
R
DS----
P
--
E
--
K
L
A
M
I
W
C
D
D
Y
-
G
N
E
K
I
F
-
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
-
I
A
E
----------
D
D
V
P
------
E
----
Q
V
D
E
A
H
A
E
C
---------------
G
D
I
P
--------
L
K
K
---
A
K
V
G
G
-------
D
V
--
L
E
G
-----------
W
I
D
F
R
K
E
L
-
E
E
S
S
----
P
I
F
E
RPTG
E
V
S
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
-
P
L
G
H
I
L
T
-
A
-
K
Y
W
Q
-
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
Y
-
D
Y
D
R
---
F
E
A
K
N
---
M
L
E
---
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
F
L
I
K
E
D
-
L
-----
N
F
---
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
---
G
---
I
K
---
L
M
E
G
F
G
Q
T
E
T
V
V
T
I
A
T
F
P
W
M
-
E
P
--
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
-------------
G
R
L
--
C
E
V
G
E
E
G
E
I
V
I
N
T
M
-
E
G
K
--
P
V
---
G
--
L
F
V
H
Y
GKD
P
E
R
T
--
E
E
---
T
----
W
H
--
D
--
G
-
Y
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
---
D
Y
T
--
P
S
D
S
L
K
N
E
L
Q
D
H
-------
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
------------------------------------
11
PsiBlast_PDB
90.64
33%
-96
- C4 -
3C5E
7
ACS2A_HUMAN
A:
[61-560]
--------------------------------------------------------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
-
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
-
G
D
E
----------
V
I
--------
Q
----
E
V
D
T
----
V
---------------
A
S
E
C
--------
P
S
----
L
R
I
K
L
L
-
V
S
--
E
K
S
--
C
D
G
-----------
W
L
N
F
K
K
L
L
-
N
E
A
S
----
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
M
-
D
-
A
G
W
T
-
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
-
L
P
K--
F
D
P
L
V
---
I
L
K
---
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
-
L
S
-
S
-
Y
K
F
---
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
-
K
--
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
-------------
G
N
V
--
L
P
P
G
T
E
G
D
I
G
I
R
V
K
P
I
-
R
--
P
I
---
G
--
I
F
S
G
Y
----
V
D
N
P
D
K
T
---
A
----
A
N
--
I
R-
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
QFL
S
H
D
--
P
E
-
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------------
15
PsiBlast_PDB
89.75
33%
-96
- C4 -
3GPC
2
ACS2A_HUMAN
A:
[61-560]
--------------------------------------------------------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
-
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
-
G
D
E
----------
V
I
--------
Q
----
E
V
D
T
----
V
---------------
A
S
E
C
--------
P
S
----
L
R
I
K
L
L
-
V
S
--
E
K
S
--
C
D
G
-----------
W
L
N
F
K
K
L
L
-
N
E
A
S
----
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
--
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
M
-
D
-
A
G
W
T
-
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
-
L
P
K--
F
D
P
L
V
---
I
L
K
---
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
-
L
S
-
S
-
Y
K
F
---
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
-
K
--
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
-------------
G
N
V
--
L
P
P
G
T
E
G
D
I
G
I
R
V
K
P
I
-
R
--
P
I
---
G
--
I
F
S
G
Y
----
V
D
N
P
D
K
T
---
A
----
A
N
--
I
R-
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
QFL
S
H
D
--
P
E
-
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------------
31
PsiBlast_CBE
89.56
33%
-96
- C4 -
3GPC
2
ACS2A_HUMAN
B:
[61-560]
--------------------------------------------------------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
-
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
-
G
D
E
----------
V
I
--------
Q
----
E
V
D
T
----
V
---------------
A
S
E
C
--------
P
S
----
L
R
I
K
L
L
-
V
S
--
E
K
S
--
C
D
G
-----------
W
L
N
F
K
K
L
L
-
N
E
A
S
----
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
---
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
M
-
D
-
A
G
W
T
-
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
-
L
P
K--
F
D
P
L
V
---
I
L
K
---
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
-
L
S
-
S
-
Y
K
F
---
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
M
-
K
--
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
-------------
G
N
V
--
L
P
P
G
T
E
G
D
I
G
I
R
V
K
P
I
-
R
--
P
I
---
G
--
I
F
S
G
Y
----
V
D
N
P
D
K
T
---
A
----
A
N
--
I
R-
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
QFL
S
H
D
--
P
E
-
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
------------------
46
HHSearch
89.15
31%
-97
- C4 -
3ETC
11
?
A:
[54-559]
----------------------------------------------------------------------
N
F
N
F
A
Y
D
V
V
D
V
Y
A
R
------
D
SP
E
--
K
L
A
M
I
W
C
D
D
Y
-
G
N
E
K
I
F
-
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
-
I
A
E
----------
D
D
--------
V
P
E
--
Q
V
D
E
----
A
---------------
H
A
E
C
--------
G
D
----
I
P
L
K
K
A
K
V
G
--
G
D
V
--
L
E
G
-----------
W
I
D
F
R
K
E
L
-
E
E
S
S
PIFE
R
P
T
G
----
E
V
S
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
-
P
L
G
H
I
L
T
-
A
-
K
Y
W
Q
-
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
Y
-
D
Y
D
R
---
F
E
A
K
N
---
M
L
E
---
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
F
L
I
K
E
D
-
L
-------
N
-
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
---
G
---
I
K
---
L
M
E
G
F
G
Q
T
E
T
V
V
T
I
A
T
F
P
W
M
---
E
P
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
-------------
G
R
L
--
C
E
V
G
E
E
G
E
I
V
I
N
T
M
-
E
-
G
K-
P
V
---
G
--
L
F
V
H
Y
----
G
K
D
--
P
E
R
T
E
E
----
T
W
--
H
--
D
G
Y
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
---
D
Y
T
--
P
S
D
S
L
K
N
E
L
Q
D
H
-------
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
------------------------------------