@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3447: (2016-02-17 )
MSGLLDLLEIRKAYGDTRVLEGVALSLAPGEVVSLLGPSGCGKSTLLRIAAGLDDDFQGTVERNPILGFGPDGENGRSGGIGVVFQEPRLLPWLTVAQNVGFADGWLEDEHWVERLLADVGLAGCGGLLPKQLSGGMAQRAAIARGLYGRPQVLLLDEPFSAVDAFTRMRLQDLLQDVVQNYEISVLLVTHDLDEAFYLADRVLLMGGRPGHIRREFHVPLARPRDRRAVELAYLRGEALTEMQRAHVL
Atome Classification :
(45 SA)
.........10...-.---.-...---20........30........40........50...-----.....60---..--...-...70.-..---....-------.80........90........100.-----.------.-----..------..--110---.--........120.---------------..----....130.......140.......150.......160.......170.......180.......190.......200....-.-------..210....---...220.......230.......240.......---------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
G
L
L
D
L
L
E
I
R
K
A
Y-G---D-T
R
V
---LE
G
V
A
L
SLAPG
E
V
V
SLLGPSGC
G
K
S
T
L
L
R
I
AAGLD-----DDFQGTV---ER--NP
I
-
L
G
FGPD-GE---NGRS-------GG
I
G
V
V
FQEPRL
L
P
W
L
T
V
A
QNVGFA-----D------G-----WL------E
D
--
E
-----
H
--
W
V
E
R
L
L
A
D
VGLA---------------GC----GGL
L
P
K
Q
LSG
G
M
A
Q
R
A
A
I
A
RGLYGR
P
Q
V
L
L
LDEP
F
S
A
V
D
A
F
T
R
M
R
L
Q
D
L
L
Q
D
V
V
QNY
E
I
S
V
L
L
V
THDL
D
E
A
F
Y
L
A
D
R
V
L
L
M-G-------GRPGH
I
R
R
E
---FHVPLARPRDR
R
A
V
E
L
A
YLR
G
E
A
L
T
E
M
Q
R
AHVL---------------------------------------------------------------------------------------------
21
PsiBlast_CBE
84.44
38%
-134
- C1 -
1Z47
1
?
B:
[14-219]
---
T
I
E
F
V
G
V
E
K
I
Y
P
G
---
G
-
A
R
S
---
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
-----
R
P
T
K
G
D
V
---
W
I
GG
K
R
V
-
T
D
L
P
P
Q
-
K
R
---
N
------------
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
LRE--
K
------
R
-----
V
P
------
K
D
--
E
-----
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
---------------
S
Y
----
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
84.24
34%
-111
- C1 -
2OLJ
4
?
A:
[22-260]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
T
N
L
---
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
------
M
-----
K
V
RKWP
R
E
K
A
--
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
---------
G
G
Y
I
I
E
E
---
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
83.80
35%
-119
- C1 -
3PUW
5
MALK_ECOLI
A:
[4-228]
----
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
-
V
V
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
TIT
S
G
D
L
F
I
G
E
K
---
R
M
--
N
D
T
-----
P
P
-
A
E
---
R
G
-----------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
L
--
A
------
G
-----
A
K
------
K
E
V
I
N
-----
Q
--
R
V
N
Q
V
A
E
V
L
Q
L
A
---------------
H
L
----
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
-----------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
83.34
35%
-121
- C1 -
3PUV
5
MALK_ECOLI
A:
[4-228]
----
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
-
V
V
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
TIT
S
G
D
L
F
I
G
E
K
---
R
M
--
N
D
T
-----
P
P
-
A
E
---
R
G
-----------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
L
--
A
------
G
-----
A
K
------
K
E
V
I
N
-----
Q
--
R
V
N
Q
V
A
E
V
L
Q
L
A
---------------
H
L
----
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
-----------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
83.07
35%
-118
- C1 -
3RLF
3
MALK_ECOLI
A:
[4-228]
----
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
-
V
V
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
TIT
S
G
D
L
F
I
G
E
K
---
R
M
--
N
D
T
-----
P
P
-
A
E
---
R
G
-----------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
L
--
A
------
G
-----
A
K
------
K
E
V
I
N
-----
Q
--
R
V
N
Q
V
A
E
V
L
Q
L
A
---------------
H
L
----
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
-----------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
83.05
35%
-119
- C1 -
3PUX
5
MALK_ECOLI
B:
[4-238]
----
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
-
V
V
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
TIT
S
G
D
L
F
I
G
E
K
---
R
M
--
N
D
T
-----
P
P
-
A
E
---
R
G
-----------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
L
--
A
------
G
-----
A
K
------
K
E
V
I
N
-----
Q
--
R
V
N
Q
V
A
E
V
L
Q
L
A
---------------
H
L
----
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
-----------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
83.05
35%
-122
- C1 -
3PUY
3
MALK_ECOLI
A:
[4-228]
----
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
-
V
V
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
TIT
S
G
D
L
F
I
G
E
K
---
R
M
--
N
D
T
-----
P
P
-
A
E
---
R
G
-----------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
L
--
A
------
G
-----
A
K
------
K
E
V
I
N
-----
Q
--
R
V
N
Q
V
A
E
V
L
Q
L
A
---------------
H
L
----
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
-----------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
82.97
32%
-136
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-239]
---
M
I
K
L
S
N
I
T
K
V
F
-
H
---
Q
G
T
R
T
IQA
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
-----
R
P
T
E
G
S
V
LV-
D
G
--
Q
E
L
-
T
T
L
S
E
S
-
E
L
---
T
K
A
R
-------
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
LEL--
D
------
N
-----
T
P
------
K
D
--
E
VK---
R
--
R
V
T
E
L
L
S
L
V
G
L
G
---------------
D
K
----
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
-
S
-------
N
-----------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
82.93
35%
-116
- C1 -
4KI0
4
?
A:
[4-228]
----
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
-
V
V
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
TIT
S
G
D
L
F
I
G
E
K
---
R
M
--
N
D
T
-----
P
P
-
A
E
---
R
G
-----------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
L
--
A
------
G
-----
A
K
------
K
E
V
I
N
-----
Q
--
R
V
N
Q
V
A
E
V
L
Q
L
A
---------------
H
L
----
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
-----------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
82.86
35%
-120
- C1 -
3PUX
5
MALK_ECOLI
A:
[4-228]
----
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
-
V
V
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
TIT
S
G
D
L
F
I
G
E
K
---
R
M
--
N
D
T
-----
P
P
-
A
E
---
R
G
-----------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
L
--
A
------
G
-----
A
K
------
K
E
V
I
N
-----
Q
--
R
V
N
Q
V
A
E
V
L
Q
L
A
---------------
H
L
----
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
-----------------------------------------------------------------------------------------------------------------------
127
Fugue
82.69
32%
-103
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
---
G
-
A
R
S
---
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
-----
R
P
T
K
G
D
V
---
W
I
--
G
----
G
K
R
V
T
-
D
L
---
P
P
Q
K
-------
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-----
L
------
R
E
K
RVP
K
D
------
E
M
--
D
-----
A
--
R
V
R
E
L
L
R
F
M
R
L
E
---------------
S
Y
----
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
-
H
-------
E
G
N
V
E
Q
F
G
T
---
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
47
PsiBlast_CBE
82.59
35%
-119
- C1 -
3PUW
5
MALK_ECOLI
B:
[4-238]
----
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
-
V
V
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
TIT
S
G
D
L
F
I
G
E
K
---
R
M
--
N
D
T
-----
P
P
-
A
E
---
R
G
-----------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
L
--
A
------
G
-----
A
K
------
K
E
V
I
N
-----
Q
--
R
V
N
Q
V
A
E
V
L
Q
L
A
---------------
H
L
----
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
-----------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
82.56
35%
-122
- C1 -
2AWN
2
MALK_ECOLI
B:
[4-228]
----
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
-
V
V
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
TIT
S
G
D
L
F
I
G
E
K
---
R
M
--
N
D
T
-----
P
P
-
A
E
---
R
G
-----------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
L
--
A
------
G
-----
A
K
------
K
E
V
I
N
-----
Q
--
R
V
N
Q
V
A
E
V
L
Q
L
A
---------------
H
L
----
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
-----------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
82.27
32%
-131
- C1 -
3TUI
1
METN_ECOLI
C:
[24-239]
---
M
I
K
L
S
N
I
T
K
V
F
-
H
---
Q
G
T
R
T
IQA
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
-----
R
P
T
E
G
S
V
LV-
D
G
--
Q
E
L
-
T
T
L
S
E
S
-
E
L
---
T
K
A
R
-------
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
LEL--
D
------
N
-----
T
P
------
K
D
--
E
VK---
R
--
R
V
T
E
L
L
S
L
V
G
L
G
---------------
D
K
----
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
-
S
-------
N
-----------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
82.17
35%
-117
- C1 -
3RLF
3
MALK_ECOLI
B:
[4-228]
----
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
-
V
V
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
TITSG
D
L
F
I
G
E
K
---
R
M
--
N
D
T
-----
P
P
-
A
E
---
R
G
-----------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
LKL--
A
------
G
-----
A
K
------
K
E
VI
N
-----
Q
--
R
V
N
Q
V
A
E
V
L
Q
L
A
---------------
H
L
----
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-------
G
R
V
A
Q
V
G
K
P
LEL
Y
H
Y
P
A
D
R
-----------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.00
38%
-128
- C1 -
1Z47
1
?
A:
[12-219]
-
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
---
G
-
A
R
S
---
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
-----
R
P
T
K
G
D
V
---
W
I
GG
K
R
V
-
T
D
L
P
P
Q
-
K
R
---
N
------------
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
R
E
--
K
------
R
-----
V
P
------
K
D
--
E
-----
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
---------------
S
Y
----
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
81.87
35%
-122
- C1 -
3PUZ
2
MALK_ECOLI
A:
[4-228]
----
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
-
V
V
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
TIT
S
G
D
L
F
I
G
E
K
---
R
M
--
N
D
T
-----
P
P
-
A
E
---
R
G
-----------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
LKL--
A
------
G
-----
A
K
------
K
E
V
I
N
-----
Q
--
R
V
N
Q
V
A
E
V
L
Q
L
A
---------------
H
L
----
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
-----------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
81.78
35%
-119
- C1 -
2R6G
2
MALK_ECOLI (first)
B:
[4-228]
----
V
Q
L
Q
N
V
T
K
A
W
-
G
---
E
-
V
V
V
---
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
TITSG
D
L
F
I
G
E
K
---
R
M
--
N
D
T
-----
P
P
-
A
E
---
R
G
-----------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
LKL--
A
------
G
-----
A
K
------
K
E
VI
N
-----
Q
--
R
V
N
Q
V
A
E
V
L
Q
L
A
---------------
H
L
----
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-------
G
R
V
A
Q
V
G
K
P
LEL
Y
H
Y
P
A
D
R
-----------------------------------------------------------------------------------------------------------------------
103
HHSearch
81.67
35%
-116
- C1 -
1Z47
1
?
A:
[13-237]
--
M
T
I
E
F
V
G
V
E
K
I
Y
-
P
G--
G
-
A
R
S
---
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
-----
R
P
T
K
G
D
V
---
W
I
--
G
G
K
-
R
V
T
D
L
-------
P
P
Q
K
-------
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-----
L
------
R
-----
E
K
RVP
K
D
-
E
M
--
D
-----
A
--
R
V
R
E
L
L
R
F
M
R
L
E
---------------
S
Y
----
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
-
H
---------
E
G
N
V
E
Q
F
---
G
T
P
E
E
V
Y
E
K
P
--------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
81.57
32%
-130
- C1 -
3TUI
1
METN_ECOLI
H:
[24-239]
---
M
I
K
L
S
N
I
T
K
V
F
-
H
---
Q
G
T
R
T
IQA
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
-----
R
P
T
E
G
S
V
LV-
D
G
--
Q
E
L
-
T
T
L
S
E
S
-
E
L
---
T
K
A
R
-------
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
LEL--
D
------
N
-----
T
P
------
K
D
--
E
VK---
R
--
R
V
T
E
L
L
S
L
V
G
L
G
---------------
D
K
----
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
-
S
-------
N
-----------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
79.96
35%
-118
- C1 -
3C41
3
?
K:
[3-219]
---
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
-
T
N
L--
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
MKVR--
K
-----
W
P
------
R
E
KA
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
-------
G
--
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
79.91
35%
-118
- C1 -
2OLJ
4
?
A:
[22-240]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
-
T
N
L
--
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
MKVR--
K
-----
W
P
------
R
E
K
A
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
-------
G
--
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
79.77
35%
-118
- C1 -
3C4J
4
?
B:
[22-240]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
-
T
N
L--
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
MKVR--
K
-----
W
P
------
R
E
KA
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
-------
G
--
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.41
33%
-110
- C1 -
4U00
3
?
A:
[3-234]
--
P
I
I
R
I
R
N
L
H
K
W
F
-
G
---
P
-
L
H
V
---
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
-----
D
F
Q
E
G
E
V
---
V
V
--
D
G
L
-
S
V
K
D
D
R
-
A
L
---
R
E
I
R
-------
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
-----
P
M
R
V
R--
R
-----
W
P
------
R
E
K
A
E
-----
K
--
K
A
L
E
L
L
E
R
V
G
I
L
---------------
D
Q
----
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
GGQIVEE
G
R
P
E
E
I
----------
F
T
R
P
K
E
E
R
T
-----------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
79.36
35%
-115
- C1 -
2OLK
2
?
B:
[22-240]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
-
T
N
L--
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
MKVR--
K
-----
W
P
------
R
E
KA
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
-------
G
--
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
79.32
36%
-113
- C1 -
4YMU
2
?
A:
[6-209]
--------
D
V
Y
K
N
F
-
G
---
S
-
L
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
-----
E
P
T
K
G
E
V
---
F
I
--
D
G
V
K
I
N
N
G
K
V
-
N
I
---
N
K
V
R
-------
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
-----
P
VKVKKM
N
-----
K
K
------
E
A
--
E
-----
E
--
L
A
V
D
L
L
A
K
V
G
L
L
---------------
D
K
----
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
---------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
79.10
35%
-117
- C1 -
2Q0H
4
?
B:
[22-240]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
-
T
N
L--
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
MKVR--
K
-----
W
P
------
R
E
K
A
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
-------
G
--
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
78.83
35%
-114
- C1 -
2OLK
1
?
D:
[22-240]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
-
T
N
L--
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
MKVR--
K
-----
W
P
------
R
E
KA
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
-------
G
--
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
78.71
35%
-113
- C1 -
2OLK
1
?
A:
[22-240]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
-
T
N
L
--
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
MKVR--
K
-----
W
P
------
R
E
K
A
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
-------
G
--
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
78.00
35%
-112
- C1 -
2OLK
1
?
C:
[22-240]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
-
T
N
L--
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
MKVR--
K
-----
W
P
------
R
E
KA
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
-------
G
--
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
78.00
35%
-113
- C1 -
3C41
3
?
J:
[3-219]
---
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
-
T
N
L--
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
MKVR--
K
-----
W
P
------
R
E
KA
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
-------
G
--
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
77.80
36%
-112
- C1 -
4YMV
1
?
A:
[6-209]
--------
D
V
Y
K
N
F
-
G
---
S
-
L
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
-----
E
P
T
K
G
E
V
---
F
I
--
D
G
V
K
I
N
N
G
K
V
-
N
I
---
N
K
V
R
-------
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
-----
P
VKVKKM
N
-----
K
K
------
E
A
--
E
-----
E
--
L
A
V
D
L
L
A
K
V
G
L
L
---------------
D
K
----
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
---------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
77.52
35%
-112
- C1 -
2OLJ
3
?
B:
[22-240]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
-
T
N
L--
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
MKVR--
K
-----
W
P
------
R
E
KA
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
-------
G
--
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.74
36%
-109
- C1 -
4YMU
2
?
J:
[6-209]
--------
D
V
Y
K
N
F
-
G
---
S
-
L
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
-----
E
P
T
K
G
E
V
---
F
I
--
D
G
V
K
I
N
N
G
K
V
-
N
I
---
N
K
V
R
-------
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
-----
P
VKVKKM
N
-----
K
K
------
E
A
--
E
-----
E
--
L
A
V
D
L
L
A
K
V
G
L
L
---------------
D
K
----
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
---------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
76.64
35%
-110
- C1 -
3C4J
3
?
A:
[22-240]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
-
T
N
L
--
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
M
K
V
R--
K
-----
W
P
------
R
E
K
A
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
-------
G
--
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
76.34
35%
-113
- C1 -
2Q0H
4
?
A:
[23-240]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
---
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-----
D
F
D
E
G
E
I
---
I
I
--
D
G
I
-
N
L
K
A
K
D
-
T
N
L
--
N
K
V
R
-------
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-----
P
M
K
V
R--
K
-----
W
P
------
R
E
K
A
E
-----
A
--
K
A
M
E
L
L
D
K
V
G
L
K
---------------
D
K
----
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
-------
G
--
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.84
36%
-110
- C1 -
4YMV
1
?
J:
[6-209]
--------
D
V
Y
K
N
F
-
G
---
S
-
L
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
-----
E
P
T
K
G
E
V
---
F
I
--
D
G
V
K
I
N
N
G
K
V
-
N
I
---
N
K
V
R
-------
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
-----
P
VKVKKM
N
-----
K
K
------
E
A
--
E
-----
E
--
L
A
V
D
L
L
A
K
V
G
L
L
---------------
D
K
----
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
---------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
71.85
34%
-116
- C1 -
3TIF
6
Y796_METJA
B:
[21-226]
---------------------------
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
-----
K
P
T
E
G
E
V
---
Y
I
--
D
N
I
-
K
T
N
D
L
D
-
D
D
ELT
K
I
R
R
-------
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
LIFKY
R
------
G
-----
A
M
------
S
G
--
E
-----
E
--
R
R
K
R
A
L
E
C
L
K
M
A
---------------
E
L
EERF
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
-
G
E
R
I
I
Y
L
----------
K
D
G
E
V
E
R
E
---------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
71.39
34%
-113
- C1 -
3TIF
7
Y796_METJA
A:
[21-226]
---------------------------
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
-----
K
P
T
E
G
E
V
---
Y
I
--
D
N
I
-
K
T
N
D
L
D
-
D
D
E
L
T
K
I
R
R
-------
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
LIFKY
R
------
G
-----
A
M
------
S
G
--
E
-----
E
--
R
R
K
R
A
L
E
C
L
K
M
A
---------------
E
L
EERF
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
-
G
E
R
I
I
Y
L
----------
K
D
G
E
V
E
R
E
---------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
70.68
34%
-113
- C1 -
1L2T
4
Y796_METJA
B:
[21-226]
---------------------------
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
-----
K
P
T
E
G
E
V
---
Y
I
--
D
N
I
-
K
T
N
D
L
D
-
D
D
ELT
K
I
R
R
-------
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
LIFKY
R
------
G
-----
A
M
------
S
G
--
E
-----
E
--
R
R
K
R
A
L
E
C
L
K
M
A
---------------
E
L
EERF
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
-
G
E
R
I
I
Y
L
----------
K
D
G
E
V
E
R
E
---------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
70.67
34%
-113
- C1 -
1L2T
4
Y796_METJA
A:
[21-226]
---------------------------
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
-----
K
P
T
E
G
E
V
---
Y
I
--
D
N
I
-
K
T
N
D
L
D
-
D
D
E
L
T
K
I
R
R
-------
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
LIFKY
R
------
G
-----
A
M
------
S
G
--
E
-----
E
--
R
R
K
R
A
L
E
C
L
K
M
A
---------------
E
L
EERF
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
-
G
E
R
I
I
Y
L
----------
K
D
G
E
V
E
R
E
---------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
69.78
33%
-143
- C1 -
1VCI
1
?
A:
[13-223]
----
V
K
L
E
N
L
T
K
R
F
-
G
---
N
-
F
T
A
---
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
-----
E
P
T
E
G
R
I
Y
FG
D
R
--
D
-
V
-
T
Y
L
P
P
K
-
D
R
---
N
------------
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
F
P
L----
K
------
K
-----
F
P
------
K
D
--
E
I
D
K
R
V
R
--
W
A
A
E
L
L
Q
---
I
E
---------------
E
L
----
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
-
N
-------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
52.04
31%
-103
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[340-543]
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
ARP
E
-
V
P
I
---
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
-----
D
P
A
S
G
T
I
---
S
L
-----------
D
-
G
H
---
D
I
R
Q
LN
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
AD---
D
------
P
-----
S
S
------
V
T
--
A
-----
E
--
E
I
Q
R
V
-
A
E
V
A
N
A
V
A
F
I
R
N
FPQGFN
T
V
V
G
E
----
K
G
V
L
---
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
--
T
V
L
V
I
A
H
R
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
51.33
31%
-99
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[340-543]
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
ARP
E
-
V
P
I
---
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
-----
D
P
A
S
G
T
I
---
S
L
-----------
D
-
G
H
---
D
I
R
Q
LN
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
AD---
D
------
P
-----
S
S
------
V
T
--
A
-----
E
--
E
I
Q
R
V
-
A
E
V
A
N
A
V
A
F
I
R
N
FPQGFNTVV
G
E
----
K
G
V
L
---
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
--
T
V
L
V
I
A
H
R
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
48.42
31%
-106
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[371-574]
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
ARP
E
-
V
P
I
---
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
-----
D
P
A
S
G
T
I
---
S
L
-----------
D
-
G
H
---
D
I
R
Q
LN
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
-
C
S
I
A
E
N
I
A
Y
G
AD---
D
------
P
-----
S
S
------
V
T
--
A
-----
E
--
E
I
Q
R
V
-
A
E
V
A
N
A
V
A
F
I
R
N
FPQGFN
T
V
V
G
E
----
K
G
V
L
---
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
--
T
V
L
V
I
A
H
H
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------