@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4202: (2016-02-24 )
MTDRFTRLLGIQQPIIQAPMLGVSTPALAAAVSNAGGLGSIAITGSAAEKGRALIREVRGLTDKPFNVNLFCHRPGQADPARERAWLDYLKPLFAEFGAEPPVRLKNIYLSFLEDPTLLPMLLEERPAAVSFHFGAPPRDQVRALQAVGIRVLVCATTPEEAALVEAAGADAVVAQGIEAGGHRGVFEPERGDAAIGTLALVRLLAARGSLPVVAAGGIMDGRGIRAALELGASAVQMGTAFVLCPESSANAAYREALKGPRAARTALTVTMSGRSARGLPNRMFFDAAAPGVPPLPDYPFVYDATKALQTAALARGNHDFAAQWAGQGAALARELPAAELLRTLVEELRG
Atome Classification :
(20 SA)
-.........10........20........30........40-....-....50........60........70........80........90..-......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260......---.270.......280.....--....290.--....-..300--.....-....310.......320.......330-....-..-.340.......350----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MT
D
R
F
T
R
L
LGIQQ
P
I
IQAPMLGVS
T
P
A
L
A
A
A
V
SNAGG
L
G
S
I
-
A
I
TG-S
A
A
E
K
G
R
A
L
I
R
E
V
RGLTDKP
F
N
V
N
L
F
C
HRPGQAD
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
-
F
A
E
FGAEP
P
V
R
L
K
N
I
Y
L
S
F
LEDP
T
L
L
P
M
L
L
EERP
A
A
V
S
F
HFGAP
P
R
D
Q
V
R
A
L
Q
A
VG
I
R
V
L
V
C
ATTPE
E
A
A
L
V
EAAGA
D
A
V
V
A
Q
G
I
EAGGHRGVFEPERGD
A
A
I
G
T
L
A
L
V
R
L
L
A
ARGSL
P
V
V
A
AGGIMDG
R
G
I
R
A
A
L
E
L
G
A
S
A
VQM
G
T
A
F
V
LCPESSA
N
A
A
Y
R
E
A
LKGPRAA
R
T
A
L
---
T
V
T
MSGRSARGL--PNR
M
F
--FDAAAPGV--PPLP-DYP----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
ARGN
H
D
F
A
A
Q
WAGQ
G
A
A
L
-
A
R
EL-
P
A
-
A
E
L
L
R
T
L
V
E
E
LRG-----------
21
PsiBlast_CBE
98.99
100%
-105
- C2 -
4Q4K
1
?
B:
[2-351]
--
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
-
F
A
E
F
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
---
T
V
T
M
S
G
R
S
A
R
G
L
--
P
N
R
M
F
--
F
D
A
A
A
P
G
V
--
P
P
L
P
-
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
L
-
P
A
-
A
E
L
L
R
T
L
V
E
E
L
R
G
-----------
22
PsiBlast_CBE
98.52
100%
-104
- C2 -
4QIS
1
?
B:
[7-355]
--
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
-
F
A
E
F
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
---
T
V
T
M
S
G
R
S
A
R
G
L
--
P
N
R
M
F
--
F
D
A
A
A
P
G
V
--
P
P
L
P
-
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
L
-
P
A
-
A
E
L
L
R
T
L
V
E
E
L
R
------------
1
PsiBlast_PDB
98.39
100%
-104
* C2 *
4Q4K
1
?
A:
[1-351]
-
M
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
-
F
A
E
F
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
---
T
V
T
M
S
G
R
S
A
R
G
L
--
P
N
R
M
F
--
F
D
A
A
A
P
G
V
--
P
P
L
P
-
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
L
-
P
A
-
A
E
L
L
R
T
L
V
E
E
L
R
G
-----------
23
PsiBlast_CBE
98.37
99%
-106
- C2 -
4QIT
2
?
B:
[8-356]
--
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
-
F
A
E
F
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
---
T
V
T
M
S
G
R
S
A
R
G
L
--
P
N
R
M
F
--
F
D
A
A
A
P
G
V
--
P
P
L
P
-
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
L
-
P
A
-
A
E
L
L
R
T
L
V
E
E
L
R
------------
24
PsiBlast_CBE
98.29
99%
-107
- C2 -
4QIU
2
?
B:
[7-356]
--
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
-
F
A
E
F
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
---
T
V
T
M
S
G
R
S
A
R
G
L
--
P
N
R
M
F
--
F
D
A
A
A
P
G
V
--
P
P
L
P
-
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
L
-
P
A
-
A
E
L
L
R
T
L
V
E
E
L
R
G
-----------
3
PsiBlast_PDB
97.81
99%
-108
- C2 -
4QIT
2
?
A:
[7-356]
-
M
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
-
F
A
E
F
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
---
T
V
T
M
S
G
R
S
A
R
G
L
--
P
N
R
M
F
--
F
D
A
A
A
P
G
V
--
P
P
L
P
-
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
L
-
P
A
-
A
E
L
L
R
T
L
V
E
E
L
R
------------
4
PsiBlast_PDB
97.56
99%
-105
- C2 -
4QIU
2
?
A:
[7-356]
--
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
-
F
A
E
F
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
---
T
V
T
M
S
G
R
S
A
R
G
L
--
P
N
R
M
F
--
F
D
A
A
A
P
G
V
--
P
P
L
P
-
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
L
-
P
A
-
A
E
L
L
R
T
L
V
E
E
L
R
G
-----------
2
PsiBlast_PDB
96.90
100%
-107
- C2 -
4QIS
1
?
A:
[9-354]
----
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
-
A
I
T
G
-
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
-
F
A
E
F
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
---
T
V
T
M
S
G
R
S
A
R
G
L
--
P
N
R
M
F
--
F
D
A
A
A
P
G
V
--
P
P
L
P
-
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
-
A
R
E
L
-
P
A
-
A
E
L
L
R
T
L
V
E
E
L
-------------
7
PsiBlast_PDB
72.57
32%
-91
- C2 -
3BO9
13
?
A:
[18-314]
----
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
-
G
S
G
A
-
M
K
P
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
V
S
P
----------
W
A
D
-----------------------------
D
L
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
T
K
-
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
---------
E
V
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
---
T
G
A
K
L
G
H
P
A
R
V
L
RT
P
F
A
R
K
--
I
Q
E
M
E
F
E
N
--
P
M
Q
A
-
E
E
M
----
L
V
G
S
L
-
R
R
A
V
V
E
G
D
L
E
R
G
S
F
M
-----
V
G
Q
S
A
G
L
-
I
D
E
I
K
P
V
-
K
Q
I
I
E
D
I
L
K
E
F
K
------------
63
HHSearch
71.99
36%
-94
- C2 -
3BO9
13
?
A:
[16-315]
--
R
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
-
G
S
G
A
-
M
K
P
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
V
S
P
W
A
---------------------------------------
D
D
L
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
T
-
K
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
E
V
---------
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
---
T
G
A
K
L
G
H
P
A
R
V
L
--
R
T
P
F
A
--
R
K
I
Q
E
M
E
---
F
E
N
--
P
M
Q
----
A
E
E
M
L
-
V
G
S
L
R
R
-
A
V
V
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
-
I
D
E
I
K
P
V
-
K
Q
I
I
E
D
I
L
K
E
F
K
E
-----------
25
PsiBlast_CBE
70.80
33%
-98
- C2 -
2Z6J
4
?
B:
[1-302]
-
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
-
G
G
G
N
-
A
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
P
-------------------------------------
F
V
E
D
--
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
S
K
Y
M
E
R
F
H
E
A
-
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
---
S
A
Q
----
A
V
R
A
I
--
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
F---------------
E
Q
M
-
G
A
G
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
-
T
A
-
E
E
I
L
K
D
L
-----------------
61
HHSearch
70.55
37%
-94
- C2 -
2Z6I
5
?
A:
[1-308]
-
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
-
G
G
G
N
-
A
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
P
F
-------------------------------------
V
--
E
D
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
S
-
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
K
L
---------
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
---
S
A
Q
H
F
G
H
A
V
R
A
I
--
K
N
Q
L
T
--
R
D
F
E
L
A
E
K
--
D
A
F
K
Q---DL
E
I
F
E
Q
M
G
-
A
G
A
L
-
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
-
V
S
K
E
E
T
A
-
E
E
I
L
K
D
L
Y
Y
G
A
A
K
-----------
5
PsiBlast_PDB
70.01
33%
-96
- C2 -
2Z6J
5
?
A:
[1-302]
-
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
-
G
G
G
N
-
A
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
P
-------------------------------------
F
V
E
D
--
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
S
K
Y
M
E
R
F
H
E
A
-
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
---
S
A
Q
---
H
A
V
R
A
I
--
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
F---------------
E
Q
M
-
G
A
G
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
-
T
A
-
E
E
I
L
K
D
L
-----------------
6
PsiBlast_PDB
68.94
32%
-94
- C2 -
2Z6I
5
?
A:
[4-302]
----
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
-
G
G
G
N
-
A
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
P
-------------------------------------
F
V
E
D
--
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
S
K
Y
M
E
R
F
H
E
A
-
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
---
S
A
Q
H
F
G
H
A
V
R
A
I
--
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
F
K
Q
----
D
L
E
----
I
F
E
Q
M
-
G
A
G
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
-
T
A
-
E
E
I
L
K
D
L
-----------------
84
Fugue
68.63
31%
-93
- C2 -
2GJL
1
2NPD_PSEAE
A:
[3-326]
V
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
-
P
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
L
P
T
Q
K
P
V
P
-----------------------------------
Y
A
E
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
-
D
P
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
E
D
D
-------
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
---
I
M
R
S
L
R
N
T
A
R
V
A
--
R
N
A
I
S
--
Q
E
V
L
A
I
E
A
--
R
G
G
A
-
G
Y
A
----
D
I
A
A
L
V
S
G
Q
R
G
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
-
I
D
D
E
P
A
C
-
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
RQR
L
E
G
M
L
A
62
HHSearch
67.54
30%
-97
- C2 -
2GJL
1
2NPD_PSEAE
A:
[4-315]
-
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
-
S
A
L
T
Q
P
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
L
P
T
Q
K
P
V
---------------------------------
P
Y
--
A
E
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
G
-
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
E
D
D
-------
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
---
I
M
R
S
L
R
N
T
A
R
V
A
--
R
N
A
I
S
--
Q
E
V
L
A
I
E
A
--
R
G
G
A
-
G
Y
A
----
D
I
A
A
L
V
S
G
Q
R
G
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
-
I
D
D
E
P
A
C
-
A
E
L
L
R
D
I
V
E
Q
A
R
Q
-----------
9
PsiBlast_PDB
67.11
30%
-88
- C2 -
2GJN
2
2NPD_PSEAE
A:
[7-314]
----
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
-
P
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
--------------
T
L
L
P
T
Q
K
P
V
P
Y
A
E
Y
R
A
A
----------------------
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
-------
E
D
D
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
MR
S
L
R
N
T
A
R
V
A
R
N
A
--
I
S
Q
E
V
--
L
A
I
E
A
R
G
G
--
A
G
Y
A
-
D
I
A
----
A
L
V
S
G
-
Q
R
G
R
Q
V
--
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
-
I
D
D
E
-
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
------------
8
PsiBlast_PDB
66.74
30%
-90
- C2 -
2GJL
1
2NPD_PSEAE
A:
[7-314]
----
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
-
P
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
--------------
T
L
L
P
T
Q
K
P
V
P
Y
A
E
Y
R
A
A
----------------------
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
-------
E
D
D
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
MR
S
L
R
N
T
A
R
V
A
R
N
A
--
I
S
Q
E
V
--
L
A
I
E
A
R
G
G
--
A
G
Y
A
-
D
I
A
----
A
L
V
S
G
-
Q
R
G
R
Q
V
--
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
-
I
D
D
E
-
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
------------
26
PsiBlast_CBE
64.16
32%
-98
- C2 -
4IQL
6
?
B:
[22-262]
---
N
R
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
-
G
A
G
S
-
M
H
P
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
---------------------
P
L
-
L
-----------------
Y
P
E
M
D
K
I
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
-
K
V
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
R
E
E
T
T
-------
T
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
---
S
L
K
A
V
S
P
T
-
R
L
L
--
K
N
K
F
Y
--
Q
D
V
F
A
-----------------------------------------------------------------------------------
10
PsiBlast_PDB
63.86
32%
-97
- C2 -
4IQL
7
?
A:
[22-262]
---
N
R
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
-
G
A
G
S
-
M
H
P
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
---------------------
P
L
-
L
-----------------
Y
P
E
M
D
K
I
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
-
K
V
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
R
E
E
T
T
-------
T
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
---
S
L
K
A
V
S
P
T
-
R
L
L
--
K
N
K
F
Y
--
Q
D
V
F
A
-----------------------------------------------------------------------------------