@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5336: (2016-03-06 )
MSGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLA
Atome Classification :
(34 SA)
.........10........20...-....--.-30...-......40--........50........60........70......--..--80........90........100.......110...--.--.....120.......130.......140-.........150...---.--...---160.......170.......180.......190.......200.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSG
T
L
Y
I
V
SAPSGA
G
K
T
S
L
V
K
A
L
L
-DAAP--
E
-
V
-
R
V
S
-
V
SHTTRGM--RPGEVDG
V
N
Y
H
FT
S
R
E
E
F
L
A
M
L
E
R
N
E
F
L
E
H
A
E
V
F
G
N
--LY--G
T
S
Q
R
W
V
E
K
T
L
A
EGL
D
L
I
L
E
IDWQ
G
A
Q
Q
V
R
R
--LMP--E--A
Q
S
I
F
I
LPP
S
Q
E
A
L
R
Q
R
L
TNRGQ
D
S
D
---
E
V
I
E
R
R
M
R
E
A
V
S
E
M
S
---
H
--
Y
V
E
---
Y
D
H
L
V
IN
D
D
F
A
H
A
L
D
D
L
K
A
I
F
R
A
R
Q
L
R
Q
D
A
Q
Q
Q
R
H
A
E
L
L
G
R
L
LA
5
PsiBlast_PDB
97.71
62%
-99
- C4 -
2F3T
1
KGUA_ECOLI
A:
[4-206]
--
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
-
K
T
Q
P
LY
D
-
T
-
Q
V
S
-
V
S
H
T
T
R
Q
P
--
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
--
K
M
P
--
H
--
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
---
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
A
E
---
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
K
L
L
A
6
PsiBlast_PDB
97.55
60%
-99
- C4 -
1S96
2
KGUA_ECOLI
A:
[16-218]
--
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
-
K
T
Q
P
LY
D
-
T
-
Q
V
S
-
V
S
H
T
T
R
Q
P
--
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
--
K
M
P
--
H
--
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
---
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
A
E
---
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
K
L
L
A
3
PsiBlast_PDB
97.25
62%
-96
- C4 -
2ANC
-
KGUA_ECOLI
A:
[4-206]
--
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
-
K
T
Q
P
LY
D
-
T
-
Q
V
S
-
V
S
H
T
T
R
Q
P
--
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
--
K
M
P
--
H
--
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
---
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
A
E
---
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
K
L
L
A
21
PsiBlast_CBE
96.67
62%
-99
- C4 -
2F3T
1
KGUA_ECOLI
F:
[4-206]
--
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
-
K
T
Q
P
LY
D
-
T
-
Q
V
S
-
V
S
H
T
T
R
Q
P
--
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
--
K
M
P
--
H
--
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
---
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
A
E
---
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
K
L
L
A
1
PsiBlast_PDB
96.59
62%
-98
- C4 -
2AN9
3
KGUA_ECOLI
A:
[4-206]
--
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
-
K
T
Q
P
LY
D
-
T
-
Q
V
S
-
V
S
H
T
T
R
Q
P
--
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
--
K
M
P
--
H
--
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
---
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
A
E
---
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
K
L
L
A
2
PsiBlast_PDB
96.45
62%
-93
- C4 -
2ANB
2
KGUA_ECOLI
A:
[4-206]
--
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
-
K
T
Q
P
LY
D
-
T
-
Q
V
S
-
V
S
H
T
T
R
Q
P
--
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
--
K
M
P
--
H
--
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
---
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
A
E
---
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
K
L
L
A
25
PsiBlast_CBE
95.26
62%
-95
- C4 -
2AN9
3
KGUA_ECOLI
B:
[4-206]
--
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
-
K
T
Q
P
LY
D
-
T
-
Q
V
S
-
V
S
H
T
T
R
Q
P
--
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
--
K
M
P
--
H
--
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
---
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
A
E
---
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
K
L
L
A
56
HHSearch
95.18
59%
-97
* C4 *
1S96
2
KGUA_ECOLI
A:
[15-216]
-
Q
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
-
K
T
Q
P
--
L
-
Y
-
D
T
Q
-
V
S
V
S
H
T
T
R
QP
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
--
K
M
P
--
H
--
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
---
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
A
E
---
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
K
L
--
22
PsiBlast_CBE
94.91
62%
-98
- C4 -
2F3T
1
KGUA_ECOLI
E:
[4-205]
--
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
-
K
T
Q
P
LY
D
-
T
-
Q
V
S
-
V
S
H
T
T
R
Q
P
--
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
--
K
M
P
--
H
--
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
G
Q
D
S
E
---
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
A
E
---
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
K
L
L
-
23
PsiBlast_CBE
94.82
62%
-101
- C4 -
2F3T
1
KGUA_ECOLI
B:
[4-206]
--
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
-
K
T
Q
P
LY
D
-
T
-
Q
V
S
-
V
S
H
T
T
R
Q
P
--
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
--
K
M
P
--
H
--
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
R
---
S
E
---
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
A
E
---
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
K
L
L
A
4
PsiBlast_PDB
94.82
62%
-96
- C4 -
2F3R
1
KGUA_ECOLI
A:
[4-206]
--
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
-
K
T
Q
P
LY
D
-
T
-
Q
V
S
-
V
S
H
T
T
R
Q
P
--
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
--
K
M
P
--
H
--
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
----
S
E
---
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
A
E
---
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
K
L
L
A
24
PsiBlast_CBE
92.42
62%
-93
- C4 -
2F3R
1
KGUA_ECOLI
B:
[4-204]
--
G
T
L
Y
I
V
S
A
P
S
G
A
G
K
S
S
L
I
Q
A
L
L
-
K
T
Q
P
LY
D
-
T
-
Q
V
S
-
V
S
H
T
T
R
Q
P
--
R
P
G
E
V
H
G
E
H
Y
F
F
V
N
H
D
E
F
K
E
M
I
S
R
D
A
F
L
E
H
A
E
V
F
G
N
--
Y
Y
--
G
T
S
R
E
A
I
E
Q
V
L
A
T
G
V
D
V
F
L
D
I
D
W
Q
G
A
Q
Q
I
R
Q
--
K
M
P
--
H
--
A
R
S
I
F
I
L
P
P
S
K
I
E
L
D
R
R
L
R
G
----
S
E
---
E
V
I
A
K
R
M
A
Q
A
V
A
E
M
S
---
H
--
Y
A
E
---
Y
D
Y
L
I
V
N
D
D
F
D
T
A
L
T
D
L
K
T
I
I
R
A
E
R
L
R
M
S
R
Q
K
Q
R
H
D
A
L
I
S
K
L
--
54
HHSearch
90.26
52%
-89
- C4 -
3TR0
3
KGUA_COXBU
A:
[5-203]
N
K
A
N
L
F
I
I
S
A
P
S
G
A
G
K
T
S
L
V
R
A
L
V
-
K
A
L
A
--
E
-
I
-
K
I
S
-
I
S
H
T
T
R
P
K
--
R
P
G
D
Q
E
G
V
D
Y
F
F
I
D
E
T
R
F
Q
A
M
V
K
E
G
A
F
L
E
H
A
T
I
Y
E
R
--
H
Y
--
G
T
E
K
D
W
V
L
R
Q
L
K
A
G
R
D
V
L
L
E
I
D
W
Q
G
A
R
Q
I
R
E
--
L
F
P
--
P
--
A
L
S
I
F
I
L
P
P
S
I
E
A
L
R
E
R
L
I
K
R
R
Q
D
D
T
---
A
I
I
E
Q
R
L
A
L
A
R
E
E
M
A
---
H
--
Y
K
E
---
F
D
Y
L
V
V
N
D
N
F
D
Q
A
V
Q
N
L
I
H
I
I
S
A
E
R
L
Q
R
D
V
----
Q
E
K
K
L
S
R
L
L
A
7
PsiBlast_PDB
89.13
50%
-85
- C4 -
3TR0
3
KGUA_COXBU
A:
[6-205]
-
K
A
N
L
F
I
I
S
A
P
S
G
A
G
K
T
S
L
V
R
A
L
V
-
K
A
L
A
--
E
-
I
-
K
I
S
-
I
S
H
T
T
R
P
K
--
R
P
G
D
Q
E
G
V
D
Y
F
F
I
D
E
T
R
F
Q
A
M
V
K
E
G
A
F
L
E
H
A
T
I
Y
E
R
--
H
Y
--
G
T
E
K
D
W
V
L
R
Q
L
K
A
G
R
D
V
L
L
E
I
D
W
Q
G
A
R
Q
I
R
E
--
L
F
P
--
P
--
A
L
S
I
F
I
L
P
P
S
I
E
A
L
R
E
R
L
I
K
R
R
Q
D
D
T
---
A
I
I
E
Q
R
L
A
L
A
R
E
E
M
A
---
H
--
Y
K
E
---
F
D
Y
L
V
V
N
D
N
F
D
Q
A
V
Q
N
L
I
H
I
I
S
A
E
R
L
Q
R
D
V
Q
E
K
K
L
S
R
L
L
A
E
L
--
18
PsiBlast_PDB
79.43
40%
-85
- C4 -
1GKY
3
KGUA_YEAST
A:
[5-186]
------
V
I
S
G
P
S
G
T
G
K
S
T
L
L
K
K
L
F
-
A
E
Y
P
--
D
S
F
-
G
F
S
-
V
S
S
T
T
R
T
P
--
R
A
G
E
V
N
G
K
D
Y
N
F
V
S
V
D
E
F
K
S
M
I
K
N
N
E
F
I
E
W
A
Q
F
S
G
N
--
Y
Y
--
G
S
T
V
A
S
V
K
Q
V
S
K
S
G
K
T
C
I
L
D
I
D
M
Q
G
V
K
S
V
K
A
--
I
-
P
--
E
LN
A
R
F
L
F
I
A
P
P
S
V
E
D
L
K
K
R
L
E
G
R
G
T
E
T
E
---
E
S
I
N
K
R
L
S
A
A
Q
A
E
L
A
------
Y
A
E
T
GA
H
D
K
V
I
V
N
D
D
L
D
K
A
Y
K
E
L
K
D
F
I
F
A
E
K
-------------------
58
HHSearch
79.42
36%
-95
- C4 -
1ZNW
-
KGUA_MYCTU
A:
[20-201]
-
V
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
V
R
C
L
R
-
E
R
I
P
--
N
-
L
-
H
F
S
-
V
S
A
T
T
R
A
P
--
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
L
H
R
S
--
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
--
T
M
P
--
E
--
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
T
E
T
A
---
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
G
D
---
F
D
K
V
V
V
N
R
R
L
E
S
A
C
A
E
L
V
S
L
L
V
----------------------
52
HHSearch
78.03
41%
-85
- C4 -
3TAU
3
KGUA_LISMO
A:
[7-204]
-
R
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
E
A
V
F
-
K
D
P
E
--
T
S
F
-
D
Y
S
-
I
S
M
T
T
R
L
P
--
R
E
G
E
Q
D
G
V
D
Y
Y
F
R
S
R
E
V
F
E
Q
A
I
K
D
G
K
M
L
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
L
E
Y
V
E
E
K
L
A
A
G
V
D
I
F
L
E
I
E
V
Q
G
A
M
Q
V
R
K
--
A
M
P
--
E
--
G
I
F
I
F
L
T
P
P
D
L
S
E
L
K
N
R
-------
S
M
---
E
V
V
E
E
R
M
E
T
A
K
K
E
I
E
---
M
--
M
A
S
---
Y
D
Y
A
V
V
N
D
V
V
A
N
A
V
Q
K
I
K
G
I
V
E
T
E
H
L
K
T
E
R
V
I
H
R
Y
K
K
M
L
-----
59
HHSearch
77.95
39%
-85
- C4 -
1EX7
3
KGUA_YEAST
A:
[1-183]
--
S
R
P
I
V
I
S
G
P
S
G
T
G
K
S
T
L
L
K
K
L
F
-
A
E
Y
P
D-
S
-
F
-
G
F
S
-
V
S
S
T
T
R
T
P
--
R
A
G
E
V
N
G
K
D
Y
N
F
V
S
V
D
E
F
K
S
M
I
K
N
N
E
F
I
E
W
A
Q
F
S
G
N
--
Y
Y
--
G
S
T
V
A
S
V
K
Q
V
S
K
S
G
K
T
C
I
L
D
I
D
M
Q
G
V
K
S
V
K
A
IP
E
L
---
N
--
A
R
F
L
F
I
A
P
P
S
V
E
D
L
K
K
R
L
E
G
R
G
T
E
T
E
---
E
S
I
N
K
R
L
S
A
A
Q
A
E
L
A
---
Y
A
E
T
G
A
---
H
D
K
V
I
V
N
D
D
L
D
K
A
Y
K
E
L
K
D
F
I
F
----------------------
13
PsiBlast_PDB
77.70
37%
-97
- C4 -
1ZNY
1
KGUA_MYCTU
A:
[20-199]
--
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
V
R
C
L
R
-
E
R
I
P
--
N
-
L
-
H
F
S
-
V
S
A
T
T
R
A
P
--
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
--
L
H
R
S
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
--
T
M
P
--
E
--
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
T
E
T
A
---
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
G
D
---
F
D
K
V
V
V
N
R
R
L
E
S
A
C
A
E
L
V
S
L
L
-----------------------
17
PsiBlast_PDB
77.61
40%
-85
- C4 -
1EX7
3
KGUA_YEAST
A:
[5-186]
------
V
I
S
G
P
S
G
T
G
K
S
T
L
L
K
K
L
F
-
A
E
Y
P
--
D
S
F
-
G
F
S
-
V
S
S
T
T
R
T
P
--
R
A
G
E
V
N
G
K
D
Y
N
F
V
S
V
D
E
F
K
S
M
I
K
N
N
E
F
I
E
W
A
Q
F
S
G
N
--
Y
Y
--
G
S
T
V
A
S
V
K
Q
V
S
K
S
G
K
T
C
I
L
D
I
D
M
Q
G
V
K
S
V
K
A
--
I
-
P
--
E
LN
A
R
F
L
F
I
A
P
P
S
V
E
D
L
K
K
R
L
E
G
R
G
T
E
T
E
---
E
S
I
N
K
R
L
S
A
A
Q
A
E
L
A
------
Y
A
E
T
GA
H
D
K
V
I
V
N
D
D
L
D
K
A
Y
K
E
L
K
D
F
I
F
A
E
K
-------------------
12
PsiBlast_PDB
77.17
37%
-101
- C4 -
1ZNX
1
KGUA_MYCTU
A:
[20-199]
--
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
V
R
C
L
R
-
E
R
I
P
--
N
-
L
-
H
F
S
-
V
S
A
T
T
R
A
P
--
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
--
L
H
R
S
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
--
T
M
P
--
E
--
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
T
E
T
A
---
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
G
D
---
F
D
K
V
V
V
N
R
R
L
E
S
A
C
A
E
L
V
S
L
L
-----------------------
10
PsiBlast_PDB
77.14
37%
-95
- C4 -
1S4Q
4
KGUA_MYCTU
A:
[23-202]
--
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
V
R
C
L
R
-
E
R
I
P
--
N
-
L
-
H
F
S
-
V
S
A
T
T
R
A
P
--
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
--
L
H
R
S
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
--
T
M
P
--
E
--
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
T
E
T
A
---
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
G
D
---
F
D
K
V
V
V
N
R
R
L
E
S
A
C
A
E
L
V
S
L
L
-----------------------
14
PsiBlast_PDB
77.00
37%
-97
- C4 -
1ZNZ
1
KGUA_MYCTU
A:
[20-199]
--
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
V
R
C
L
R
-
E
R
I
P
--
N
-
L
-
H
F
S
-
V
S
A
T
T
R
A
P
--
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
--
L
H
R
S
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
--
T
M
P
--
E
--
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
T
E
T
A
---
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
G
D
---
F
D
K
V
V
V
N
R
R
L
E
S
A
C
A
E
L
V
S
L
L
-----------------------
15
PsiBlast_PDB
76.60
37%
-96
- C4 -
1Z8F
2
KGUA_MYCTU
A:
[23-202]
--
G
R
V
V
V
L
S
G
P
S
A
V
G
K
S
T
V
V
R
C
L
R
-
E
R
I
P
--
N
-
L
-
H
F
S
-
V
S
A
T
T
R
C
P
--
R
P
G
E
V
D
G
V
D
Y
H
F
I
D
P
T
R
F
Q
Q
L
I
D
Q
G
E
L
L
E
W
A
E
I
H
G
G
--
L
H
R
S
G
T
L
A
Q
P
V
R
A
A
A
A
T
G
V
P
V
L
I
E
V
D
L
A
G
A
R
A
I
K
K
--
T
M
P
--
E
--
A
V
T
V
F
L
A
P
P
S
W
Q
D
L
Q
A
R
L
I
G
R
G
C
E
T
A
---
D
V
I
Q
R
R
L
D
T
A
R
I
E
L
A
---
A
--
Q
G
D
---
F
D
K
V
V
V
N
R
R
L
E
S
A
C
A
E
L
V
S
L
L
-----------------------
57
HHSearch
76.59
36%
-73
- C4 -
1LVG
3
KGUA_MOUSE
A:
[5-190]
---
R
P
V
V
L
S
G
P
S
G
A
G
K
S
T
L
L
K
K
L
F
-
Q
E
H
S
--
S
I
F
-
G
F
S
-
V
S
H
T
T
R
N
P
--
R
P
G
E
E
D
G
K
D
Y
Y
F
V
T
R
E
M
M
Q
R
D
I
A
A
G
D
F
I
E
H
A
E
F
S
G
N
--
L
Y
--
G
T
S
K
E
A
V
R
A
V
Q
A
M
N
R
I
C
V
L
D
V
D
L
Q
G
V
R
S
I
K
K
--
T
D
L
--
C
--
P
I
Y
I
F
V
Q
P
P
S
L
D
V
L
E
Q
R
L
R
L
R
N
T
E
T
E
---
E
S
L
A
K
R
L
A
A
A
R
T
D
M
E
SSK
E
--
P
G
L
---
F
D
L
V
I
I
N
D
D
L
D
K
A
Y
A
T
L
K
Q
A
L
S
E
E
I
K
------------------
53
HHSearch
75.71
32%
-76
- C4 -
2QOR
2
?
A:
[11-198]
-
R
I
P
P
L
V
V
C
G
P
S
G
V
G
K
G
T
L
I
K
K
V
L
-
S
E
F
P
S-
R
-
F
-
R
F
S
-
I
S
C
T
T
R
N
K
--
R
E
K
E
T
N
G
V
D
Y
Y
F
V
D
K
D
D
F
E
R
K
L
K
E
G
Q
F
L
E
F
D
K
Y
A
N
N
--
F
Y
--
G
T
L
K
S
E
Y
D
L
A
V
G
E
G
K
I
C
L
F
E
M
N
I
N
G
V
K
Q
L
K
E
--
S
K
H
IQ
D
--
G
I
Y
I
F
V
K
P
P
S
I
D
I
L
L
G
R
L
K
N
R
N
T
E
K
P
---
E
E
I
N
K
R
M
Q
E
L
T
R
E
M
D
---
E
A
D
K
V
G
---
F
N
Y
F
I
V
N
D
D
L
A
R
T
Y
A
E
L
R
E
Y
L
L
G
S
Y
-------------------
26
PsiBlast_CBE
75.14
40%
-86
- C4 -
4QRH
6
?
D:
[8-203]
-
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
D
P
S
T
--
S
-
Y
-
K
Y
S
-
I
S
M
T
T
R
Q
M
--
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
--
K
F
P
--
D
--
A
L
F
I
F
L
A
P
P
S
L
E
H
L
-----------------
I
Q
S
R
I
N
E
A
R
K
E
V
E
---
M
--
M
N
L
---
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
Y
R
K
-------
20
PsiBlast_PDB
74.26
38%
-66
- C4 -
1LVG
3
KGUA_MOUSE
A:
[8-182]
------
V
L
S
G
P
S
G
A
G
K
S
T
L
L
K
K
L
F
-
Q
E
H
S
--
S
-
I
F
G
F
S
-
V
S
H
T
T
R
N
P
--
R
P
G
E
E
D
G
K
D
Y
Y
F
V
T
R
E
M
M
Q
R
D
I
A
A
G
D
F
I
E
H
A
E
F
S
G
N
--
L
Y
--
G
T
S
K
E
A
V
R
A
V
Q
A
M
N
R
I
C
V
L
D
V
D
L
Q
G
V
R
S
I
K
K
--
T
D
L
--
C
--
P
I
Y
I
F
V
Q
P
P
S
L
D
V
L
E
Q
R
L
R
L
R
N
T
E
T
E
---
E
S
L
A
K
R
L
A
A
A
R
T
D
M
E
---
S
--
S
K
E
PGL
F
D
L
V
I
I
N
D
D
L
D
K
A
Y
A
T
L
K
--------------------------
27
PsiBlast_CBE
74.01
40%
-84
- C4 -
4QRH
4
?
C:
[8-205]
-
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
D
P
S
T
--
S
-
Y
-
K
Y
S
-
I
S
M
T
T
R
Q
M
--
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
--
K
F
P
--
D
--
A
L
F
I
F
L
A
P
P
S
L
E
H
L
---------------------
I
N
E
A
R
K
E
V
E
---
M
--
M
N
L
---
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
Y
R
K
M
I
-----
29
PsiBlast_CBE
73.78
40%
-94
- C4 -
2J41
4
KGUA_STAAC
D:
[5-202]
-
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
D
P
S
T
--
S
-
Y
-
K
Y
S
-
I
S
M
T
T
R
Q
M
--
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
--
K
F
P
--
D
--
A
L
F
I
F
L
A
P
P
S
---------------------------
E
A
R
K
E
V
E
---
M
--
M
N
L
---
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
Y
R
K
M
I
-----
31
PsiBlast_CBE
73.65
40%
-92
- C4 -
2J41
3
KGUA_STAAC
B:
[5-202]
-
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
D
P
S
T
--
S
-
Y
-
K
Y
S
-
I
S
M
T
T
R
Q
M
--
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
--
K
F
P
--
D
--
A
L
F
I
F
L
A
P
P
S
-------------------------------
E
V
E
---
M
--
M
N
L
---
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
Y
R
K
M
I
-----
28
PsiBlast_CBE
73.58
40%
-84
- C4 -
4QRH
3
?
B:
[8-205]
-
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
D
P
S
T
--
S
-
Y
-
K
Y
S
-
I
S
M
T
T
R
Q
M
--
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
--
K
F
P
--
D
--
A
L
F
I
F
L
A
P
P
S
L
E
H
L
----------------------
N
E
A
R
K
E
V
E
---
M
--
M
N
L
---
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
Y
R
K
M
I
-----
30
PsiBlast_CBE
72.97
40%
-91
- C4 -
2J41
3
KGUA_STAAC
C:
[5-197]
-
K
G
L
L
I
V
L
S
G
P
S
G
V
G
K
G
T
V
R
K
R
I
F
E
D
P
S
T
--
S
-
Y
-
K
Y
S
-
I
S
M
T
T
R
Q
M
--
R
E
G
E
V
D
G
V
D
Y
F
F
K
T
R
D
A
F
E
A
L
I
K
D
D
Q
F
I
E
Y
A
E
Y
V
G
N
--
Y
Y
--
G
T
P
V
Q
Y
V
K
D
T
M
D
E
G
H
D
V
F
L
E
I
E
V
E
G
A
K
Q
V
R
K
--
K
F
P
--
D
--
A
L
F
I
F
L
A
P
P
S
----------------------
Q
S
R
I
N
E
A
R
K
E
V
E
---
M
--
M
N
L
---
Y
D
Y
V
V
V
N
D
E
V
E
L
A
K
N
R
I
Q
C
I
V
E
A
E
H
L
K
R
E
R
V
E
A
K
----------
35
PsiBlast_CBE
64.35
34%
-71
- C4 -
4WSI
1
MPP5_HUMAN
A:
[202-374]
------
I
L
I
G
P
Q
N
C
G
Q
N
E
L
R
Q
R
L
M
-
N
K
E
K
--
D
-
R
-
F
A
S
A
V
P
H
T
T
R
S
R
--
R
D
Q
E
V
A
G
R
D
Y
H
F
V
S
R
Q
A
F
E
A
D
I
A
A
G
K
F
I
E
H
G
E
F
E
K
N
--
L
Y
--
G
T
S
I
D
S
V
R
Q
V
I
N
S
G
K
I
C
L
L
S
L
R
T
Q
S
L
K
T
L
R
N
--
S
D
L
--
K
--
P
Y
I
I
F
I
A
P
P
S
Q
E
R
L
R
A
L
L
--------E
L
R
E
I
I
E
-
K
T
R
E
M
E
Q
N
N
G
---
H
--
Y
-----
F
D
T
A
I
V
N
S
D
L
D
K
A
Y
Q
E
L
---------------------------