@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5516: (2016-03-08 )
MPRTPHLLAIQSHVVFGHAGNAAAVFPMQRIGINVWPLNTVQFSNHTQYGRWTGQVLPPEQIPALVDGIAGIGELGNCDAVLSGYLGSAAQGRAILDVVARIKQANPRALYLCDPVMGHPEKGCIVAPEVSDFLLEEAAAVADYLCPNQLELDSFCDRQPNSLADCVEMARSLLARGPRAILVKHLNYPGKAGDTFEMLLVAADQAWHLQRPLLAFPRQPVGVGDLASGLFLSRLLLGDDLRNAFEFTGAAVHEVLLETQACGSYELELVRAQDRIAHPRVRFDAVRL
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.--...---.....130..---.----....140.......150.......160.......170.......180.......190......--.200---...-..-------...-------.210...-.-.-..220-.-----........230......-.240.......250.......260.-------------.-------------.-------------....270.......280......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPRT
P
H
L
L
A
I
Q
S
H
V
V
FGHAGN
A
A
A
V
F
P
M
Q
R
I
G
I
N
V
W
PL
N
T
V
Q
FSNHTQYGRWTGQVL
P
P
E
Q
I
P
A
L
V
D
G
I
A
GIGELG
N
C
D
A
V
L
S
G
YLGSAAQ
G
R
A
I
L
D
V
V
A
R
I
KQANP
R
A
L
Y
L
CDPVMGHP--E--KG
C
---
I
VAP
E
V
S
D
F
L
---
L
----
E
E
A
A
A
V
A
D
YLCPNQL
E
L
D
S
F
CDRQP
N
S
L
A
D
C
V
E
M
A
R
S
L
L
ARG
P
R
A
I
L
VKHLNYPGKAG
D
T
F
E
M
--
L
L
-----
V
AA-DQ-------AWH-------LQR
P
L
L
A-F-P-RQP---V-----
G
V
G
D
L
A
S
G
L
F
L
S
R
L
L
L
G
-
D
D
L
R
N
A
F
E
F
T
G
A
A
V
H
E
V
L
L
E
TQACG-------------S-------------
Y
-------------
E
L
E
L
V
RA
Q
D
RIAHP
R
V
R
F
DAVRL
1
PsiBlast_PDB
97.81
57%
-124
- C4 -
1TD2
1
PDXY_ECOLI
A:
[4-287]
-----
N
I
L
A
I
Q
S
H
V
V
Y
G
H
A
G
N
S
A
A
E
F
P
M
R
R
L
G
A
N
V
W
P
L
N
T
V
Q
F
S
N
H
T
Q
Y
G
K
W
T
G
C
V
M
P
P
S
H
L
T
E
I
V
Q
G
I
A
A
I
D
K
L
H
T
C
D
A
V
L
S
G
Y
L
G
S
A
E
Q
G
E
H
I
L
G
I
V
R
Q
V
K
A
A
N
P
Q
A
K
Y
F
C
D
P
V
M
G
H
P
--
E
--
K
G
C
---
I
V
A
P
G
V
A
E
F
H
---
V
----
R
H
G
L
P
A
S
D
I
I
A
P
N
L
V
E
L
E
I
L
C
E
H
A
V
N
N
V
E
E
A
V
L
A
A
R
E
L
I
A
Q
G
P
Q
I
V
L
V
K
H
L
A
R
A
G
Y
S
R
D
R
F
E
M
--
L
L
-----
V
T
A
-
D
E
-------
A
W
H
-------
I
S
R
P
L
V
D
-
F
-
G
M
R
Q
P
---
V
-----
G
V
G
D
V
T
S
G
L
L
L
V
K
L
L
Q
G
-
A
T
L
Q
E
A
L
E
H
V
T
A
A
V
Y
E
I
M
V
T
T
K
A
M
Q
-------------
E
-------------
Y
-------------
E
L
Q
V
V
A
A
Q
D
R
I
A
K
P
E
H
Y
F
S
A
T
K
L
2
PsiBlast_PDB
97.52
58%
-126
- C4 -
3PZS
7
PDXY_YERPE
A:
[6-289]
-----
N
I
L
S
I
Q
S
H
V
V
F
G
H
A
G
N
S
A
A
E
F
P
M
R
R
M
G
V
N
V
W
P
L
N
T
V
Q
F
S
N
H
T
Q
Y
G
H
W
T
G
C
V
M
P
A
S
H
L
T
D
I
V
Q
G
I
A
D
I
D
R
L
K
D
C
D
A
V
L
S
G
Y
I
G
S
P
E
Q
G
S
H
I
L
A
A
V
A
Q
V
K
Q
A
N
P
D
A
W
Y
F
C
D
P
V
M
G
H
P
--
E
--
K
G
C
---
I
V
A
P
G
V
A
E
F
F
---
C
----
N
E
A
L
P
A
S
D
M
I
A
P
N
L
L
E
L
E
Q
L
S
G
E
R
V
E
N
V
E
Q
A
V
Q
V
A
R
S
L
C
A
R
G
P
K
V
V
L
V
K
H
L
S
R
A
G
Y
H
A
D
C
F
E
M
--
L
L
-----
V
T
A
-
D
D
-------
A
W
H
-------
I
C
R
P
L
V
D
-
F
G
K
-
R
Q
P
---
V
-----
G
V
G
D
L
T
S
G
L
L
L
V
N
L
L
K
G
-
E
P
L
D
K
A
L
E
H
V
T
A
A
V
Y
E
V
M
L
K
T
Q
E
M
G
-------------
E
-------------
Y
-------------
E
L
Q
V
V
A
A
Q
E
T
I
V
T
P
I
C
Q
F
T
A
V
R
L
21
PsiBlast_CBE
96.70
57%
-123
- C4 -
1TD2
2
PDXY_ECOLI
B:
[4-287]
-----
N
I
L
A
I
Q
S
H
V
V
Y
G
H
A
G
N
S
A
A
E
F
P
M
R
R
L
G
A
N
V
W
P
L
N
T
V
Q
F
S
N
H
T
Q
Y
G
K
W
T
G
C
V
M
P
P
S
H
L
T
E
I
V
Q
G
I
A
A
I
D
K
L
H
T
C
D
A
V
L
S
G
Y
L
G
S
A
E
Q
G
E
H
I
L
G
I
V
R
Q
V
K
A
A
N
P
Q
A
K
Y
F
C
D
P
V
M
G
H
P
--
E
--
K
G
C
---
I
V
A
P
G
V
A
E
F
H
---
V
----
R
H
G
L
P
A
S
D
I
I
A
P
N
L
V
E
L
E
I
L
C
E
H
A
V
N
N
V
E
E
A
V
L
A
A
R
E
L
I
A
Q
G
P
Q
I
V
L
V
K
H
L
A
R
A
G
Y
S
R
D
R
F
E
M
--
L
L
-----
V
T
A
-
D
E
-------
A
W
H
-------
I
S
R
P
L
V
D
-
F
-
G
M
R
Q
P
---
V
-----
G
V
G
D
V
T
S
G
L
L
L
V
K
L
L
Q
G
-
A
T
L
Q
E
A
L
E
H
V
T
A
A
V
Y
E
I
M
V
T
T
K
A
M
Q
-------------
E
-------------
Y
-------------
E
L
Q
V
V
A
A
Q
D
R
I
A
K
P
E
H
Y
F
S
A
T
K
L
31
HHSearch
96.52
58%
-124
- C4 -
3PZS
7
PDXY_YERPE
A:
[5-289]
----
K
N
I
L
S
I
Q
S
H
V
V
F
G
H
A
G
N
S
A
A
E
F
P
M
R
R
M
G
V
N
V
W
P
L
N
T
V
Q
F
S
N
H
T
Q
Y
G
H
W
T
G
C
V
M
P
A
S
H
L
T
D
I
V
Q
G
I
A
D
I
D
R
L
K
D
C
D
A
V
L
S
G
Y
I
G
S
P
E
Q
G
S
H
I
L
A
A
V
A
Q
V
K
Q
A
N
P
D
A
W
Y
F
C
D
P
V
M
G
H
P
--
E
--
K
G
C
---
I
V
A
P
G
V
A
E
F
F
---
C
----
N
E
A
L
P
A
S
D
M
I
A
P
N
L
L
E
L
E
Q
L
S
G
E
R
V
E
N
V
E
Q
A
V
Q
V
A
R
S
L
C
A
R
G
P
K
V
V
L
V
K
H
L
S
R
A
G
Y
H
A
D
C
F
E
M
--
L
L
-----
V
T
A
-
D
D
-------
A
W
H
-------
I
C
R
P
L
V
D
F
G
-
K
-
R
Q
P
---
V
-----
G
V
G
D
L
T
S
G
L
L
L
V
N
L
L
K
G
-
E
P
L
D
K
A
L
E
H
V
T
A
A
V
Y
E
V
M
L
K
T
Q
E
M
G
-------------
E
-------------
Y
-------------
E
L
Q
V
V
A
A
Q
E
T
I
V
T
P
I
C
Q
F
T
A
V
R
L
53
Fugue
78.81
33%
-112
- C4 -
1LHP
-
PDXK_SHEEP
A:
[4-312]
---
E
C
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
S
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
D
G
L
K
L
-
N
H
V
N
Q
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
M
G
D
Q
--
R
--
N
G
E
GAM
Y
V
P
D
D
L
L
P
V
Y
---
R
----
E
K
V
V
P
V
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
T
G
R
K
I
H
S
Q
E
E
A
L
E
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
N
L
L
S
P
R
G
S
D
Y
L
M
--
A
L
-----
G
S
Q
-
R
T
-------
R
G
S
-------
V
V
T
Q
R
I
R
-
M
-
E
-
M
H
K
---
V
D
A
V
F
V
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
A
M
H
H
V
L
Q
R
T
I
K
C
A
-------------
K
-------------
A
K
SGEGVKPSPAQL
E
L
R
M
V
Q
S
K
K
D
I
E
S
P
E
I
V
V
Q
A
T
V
L
13
PsiBlast_PDB
78.30
29%
-112
- C4 -
2YXT
7
PDXK_HUMAN
A:
[3-312]
--
E
E
C
R
V
L
S
I
Q
S
H
V
I
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
I
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
A
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
E
G
L
R
-
L
N
N
M
N
K
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
L
G
D
K
--
G
--
E
G
S
---
M
Y
V
P
E
--
D
L
L
P
V
Y
K
----
E
K
V
V
P
L
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
S
G
R
K
I
H
S
Q
E
E
A
L
R
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
D
L
P
S
P
Q
G
S
N
Y
----
L
I
-----
V
L
G
-
S
Q
-------
R
R
-G
S
V
V
---
M
E
R
I
R
M
D
-
I
-
R
-
K
V
D
A
V
F
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
T
L
H
H
V
L
Q
R
T
I
Q
C
A
-------------
K
A
Q
A
GEG
V
R
P
S
PMQ
L
-------------
E
L
R
M
V
Q
S
K
R
D
I
E
D
P
E
I
V
V
Q
A
T
V
L
14
PsiBlast_PDB
77.75
29%
-114
- C4 -
2YXU
8
PDXK_HUMAN
A:
[3-312]
--
E
E
C
R
V
L
S
I
Q
S
H
V
I
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
I
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
A
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
E
G
L
R
-
L
N
N
M
N
K
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
L
G
D
K
W
D
G
--
E
G
S
---
M
Y
V
P
E
--
D
L
L
P
V
Y
K
----
E
K
V
V
P
L
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
S
G
R
K
I
H
S
Q
E
E
A
L
R
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
D
L
P
S
P
Q
G
S
N
Y
----
L
I
-----
V
L
G
-
S
Q
-------
R
R
-GSV
V
---
M
E
R
I
R
M
D
-
I
-
R
-
K
V
D
A
V
F
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
T
L
H
H
V
L
Q
R
T
I
Q
C
A
-------------
K
A
Q
A
GEG
V
R
P
S
PMQ
L
-------------
E
L
R
M
V
Q
S
K
R
D
I
E
D
P
E
I
V
V
Q
A
T
V
L
11
PsiBlast_PDB
77.66
29%
-113
- C4 -
2AJP
26
PDXK_HUMAN
A:
[19-326]
----
S
R
V
L
S
I
Q
S
H
V
I
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
I
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
A
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
E
G
L
R
-
L
N
N
M
N
K
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
L
G
D
K
WD
G
--
E
G
S
---
M
Y
V
P
E
--
D
L
L
P
V
Y
K
----
E
K
V
V
P
L
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
S
G
R
K
I
H
S
Q
E
E
A
L
R
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
D
L
P
S
P
Q
G
S
N
Y
L
I
--
V
L
-----
G
S
Q
-
R
R
R-------
V
V
-------
M
E
R
I
R
M
D
-
I
-
R
-
K
V
D
A
V
F
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
T
L
H
H
V
L
Q
R
T
I
Q
C
A
-------------
K
A
Q
A
GEG
V
R
P
S
PMQ
L
-------------
E
L
R
M
V
Q
S
K
R
D
I
E
D
P
E
I
V
V
Q
A
T
V
L
6
PsiBlast_PDB
77.03
33%
-117
- C4 -
1RFU
3
PDXK_SHEEP
A:
[1-312]
M
E
E
E
C
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
S
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
D
G
L
K
-
L
N
H
V
N
Q
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
M
G
D
Q
--
R
--
N
G
E
----
G
A
M
Y
V
P
D
D
L
---
L
P
V
Y
R
E
K
V
V
P
V
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
T
G
R
K
I
H
S
Q
E
E
A
L
E
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
N
L
L
S
P
R
G
S
D
Y
L
M
--
A
L
G
S
Q
R
T
R
A
P
-
D
G
-------
S
V
V
-------
T
Q
R
I
R
M
E
-
M
-
H
-
K
V
D
A
V
F
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
A
M
H
H
V
L
Q
R
T
I
K
C
A
-------------
K
A
K
S
GEG
V
K
P
S
PAQ
L
-------------
E
L
R
M
V
Q
S
K
K
D
I
E
S
P
E
I
V
V
Q
A
T
V
L
16
PsiBlast_PDB
76.90
29%
-114
- C4 -
4EN4
9
PDXK_HUMAN
A:
[3-312]
--
E
E
C
R
V
L
S
I
Q
S
H
V
I
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
I
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
A
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
E
G
L
R
-
L
N
N
M
N
K
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
L
G
D
K
W
D
G
--
E
G
S
---
M
Y
V
P
E
--
D
L
L
P
V
Y
K
----
E
K
V
V
P
L
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
S
G
R
K
I
H
S
Q
E
E
A
L
R
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
D
L
P
S
P
Q
G
S
N
Y
----
L
I
-----
V
L
G
-
S
Q
-------
R
R
R
N
PA
G
S
V
V
M
E
R
I
R
M
D
-
I
-
R
-
K
V
D
A
V
F
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
T
L
H
H
V
L
Q
R
T
I
Q
C
A
-------------
K
A
Q
A
GEG
V
R
P
S
PMQ
L
-------------
E
L
R
M
V
Q
S
K
R
D
I
E
D
P
E
I
V
V
Q
A
T
V
L
28
PsiBlast_CBE
76.89
33%
-118
- C4 -
1RFU
3
PDXK_SHEEP
C:
[1-312]
M
E
E
E
C
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
S
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
D
G
L
K
-
L
N
H
V
N
Q
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
M
G
D
Q
--
R
--
N
G
E
----
G
A
M
Y
V
P
D
D
L
---
L
PVYR
E
K
V
V
P
V
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
T
G
R
K
I
H
S
Q
E
E
A
L
E
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
N
L
L
S
P
R
G
S
D
Y
L
M
--
A
L
GSQRT
R
A
P
-
D
G
-------
S
V
V
-------
T
Q
R
I
R
M
E
-
M
-
H
-
K
V
D
AVF
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
A
M
H
H
V
L
Q
R
T
I
K
C
A
-------------
K
AKSGEGVKPSPAQ
L
-------------
E
L
R
M
V
Q
S
K
K
D
I
E
S
P
E
I
V
V
Q
A
T
V
L
22
PsiBlast_CBE
76.85
33%
-114
- C4 -
1RFV
2
PDXK_SHEEP
B:
[4-312]
---
E
C
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
S
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
D
G
L
K
-
L
N
H
V
N
Q
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
M
G
D
Q
--
R
--
N
G
E
----
G
A
M
Y
V
P
D
D
L
---
L
P
V
Y
R
E
K
V
V
P
V
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
T
G
R
K
I
H
S
Q
E
E
A
L
E
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
N
L
L
S
P
R
G
S
D
Y
L
M
--
A
L
G
S
Q
R
T
R
A
P
-
D
G
-------
S
V
V
-------
T
Q
R
I
R
M
E
-
M
-
H
-
K
V
D
A
V
F
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
A
M
H
H
V
L
Q
R
T
I
K
C
A
-------------
K
A
K
S
GEGVKPSPAQ
L
-------------
E
L
R
M
V
Q
S
K
K
D
I
E
S
P
E
I
V
V
Q
A
T
V
L
15
PsiBlast_PDB
76.54
29%
-111
- C4 -
3KEU
10
PDXK_HUMAN
A:
[3-312]
--
E
E
C
R
V
L
S
I
Q
S
H
V
I
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
I
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
A
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
E
G
L
R
-
L
N
N
M
N
K
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
L
G
D
K
W
D
G
--
E
G
S
---
M
Y
V
P
E
--
D
L
L
P
V
Y
K
----
E
K
V
V
P
L
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
S
G
R
K
I
H
S
Q
E
E
A
L
R
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
D
L
P
S
P
Q
G
S
N
Y
----
L
I
-----
V
L
G
-
S
Q
-------
R
R
-S
V
V
----
M
E
R
I
R
M
D
-
I
-
R
-
K
V
D
A
V
F
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
T
L
H
H
V
L
Q
R
T
I
Q
C
A
-------------
K
A
Q
A
GEGVRPSPMQ
L
-------------
E
L
R
M
V
Q
S
K
R
D
I
E
D
P
E
I
V
V
Q
A
T
V
L
32
HHSearch
76.48
31%
-109
- C4 -
2YXT
7
PDXK_HUMAN
A:
[3-312]
--
E
E
C
R
V
L
S
I
Q
S
H
V
I
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
I
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
A
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
E
G
L
R
L
N
N
-
M
N
K
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
L
G
D
K
---G
E
G
S
M
---
Y
V
P
E
D
L
L
P
V
Y
---
K
----
E
K
V
V
P
L
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
S
G
R
K
I
H
S
Q
E
E
A
L
R
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
D
L
P
S
P
----
Q
G
S
N
Y
L
I
-----
V
L
G
S
Q
R
RG
S
V
V
M
E
R
I
R
-------
M
D
I
R
K
V
D
-----
A
V
F
---
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
T
L
H
H
V
L
Q
R
T
I
Q
C
A
K
A
Q
A
GEG
V
R
P
S
PM
Q
-------------
L
-------------
E
L
R
M
V
Q
S
K
R
D
I
E
D
P
E
I
V
V
Q
A
T
V
L
27
PsiBlast_CBE
76.34
33%
-115
- C4 -
1RFU
3
PDXK_SHEEP
D:
[1-312]
M
E
E
E
C
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
S
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
D
G
L
K
-
L
N
H
V
N
Q
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
M
G
D
Q
--
R
--
N
G
E
----
G
A
M
Y
V
P
D
D
L
---
L
PVYR
E
K
V
V
P
V
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
T
G
R
K
I
H
S
Q
E
E
A
L
E
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
N
L
L
S
P
R
G
S
D
Y
L
M
--
A
L
GSQRT
R
A
P
-
D
G
-------
S
V
V
-------
T
Q
R
I
R
M
E
-
M
-
H
-
K
V
D
AVF
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
A
M
H
H
V
L
Q
R
T
I
K
C
A
-------------
K
AKSGEGVKPSPAQ
L
-------------
E
L
R
M
V
Q
S
K
K
D
I
E
S
P
E
I
V
V
Q
A
T
V
L
25
PsiBlast_CBE
76.30
33%
-117
- C4 -
1RFU
1
PDXK_SHEEP
F:
[1-312]
M
E
E
E
C
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
S
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
D
G
L
K
-
L
N
H
V
N
Q
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
M
G
D
Q
--
R
--
N
G
E
----
G
A
M
Y
V
P
D
D
L
---
L
PVYR
E
K
V
V
P
V
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
T
G
R
K
I
H
S
Q
E
E
A
L
E
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
N
L
L
S
P
R
G
S
D
Y
L
M
--
A
L
GSQRT
R
A
P
-
D
G
-------
S
V
V
-------
T
Q
R
I
R
M
E
-
M
-
H
-
K
V
D
AVF
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
A
M
H
H
V
L
Q
R
T
I
K
C
A
-------------
K
AKSGEGVKPSPAQ
L
-------------
E
L
R
M
V
Q
S
K
K
D
I
E
S
P
E
I
V
V
Q
A
T
V
L
29
PsiBlast_CBE
75.92
33%
-116
- C4 -
1RFU
3
PDXK_SHEEP
B:
[1-312]
M
E
E
E
C
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
S
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
D
G
L
K
-
L
N
H
V
N
Q
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
M
G
D
Q
--
R
--
N
G
E
----
G
A
M
Y
V
P
D
D
L
---
L
PVYR
E
K
V
V
P
V
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
T
G
R
K
I
H
S
Q
E
E
A
L
E
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
N
L
L
S
P
R
G
S
D
Y
L
M
--
A
L
GSQRT
R
A
P
-
D
G
-------
S
V
V
-------
T
Q
R
I
R
M
E
-
M
-
H
-
K
V
D
AVF
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
A
M
H
H
V
L
Q
R
T
I
K
C
A
-------------
K
AKSGEGVKPSPAQ
L
-------------
E
L
R
M
V
Q
S
K
K
D
I
E
S
P
E
I
V
V
Q
A
T
V
L
24
PsiBlast_CBE
75.63
33%
-116
- C4 -
1RFU
1
PDXK_SHEEP
G:
[1-312]
M
E
E
E
C
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
S
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
D
G
L
K
-
L
N
H
V
N
Q
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
M
G
D
Q
--
R
--
N
G
E
----
G
A
M
Y
V
P
D
D
L
---
L
PVYR
E
K
V
V
P
V
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
T
G
R
K
I
H
S
Q
E
E
A
L
E
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
N
L
L
S
P
R
G
S
D
Y
L
M
--
A
L
GSQRT
R
A
P
-
D
G
-------
S
V
V
-------
T
Q
R
I
R
M
E
-
M
-
H
-
K
V
D
AVF
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
A
M
H
H
V
L
Q
R
T
I
K
C
A
-------------
K
AKSGEGVKPSPAQ
L
-------------
E
L
R
M
V
Q
S
K
K
D
I
E
S
P
E
I
V
V
Q
A
T
V
L
30
PsiBlast_CBE
75.47
33%
-112
- C4 -
1LHR
3
PDXK_SHEEP
B:
[4-312]
---
E
C
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
S
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
D
G
L
K
-
L
N
H
V
N
Q
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
M
G
D
Q
--
R
--
N
G
E
----
G
A
M
Y
V
P
D
D
L
---
L
P
V
Y
R
E
K
V
V
P
V
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
T
G
R
K
I
H
S
Q
E
E
A
L
E
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
N
L
L
S
P
R
G
S
D
Y
L
M
--
A
L
G
S
Q
R
T
R
A
P
-
D
G
-------
S
V
V
-------
T
Q
R
I
R
M
E
-
M
-
H
-
K
V
D
A
V
F
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
A
M
H
H
V
L
Q
R
T
I
K
C
A
-------------
K
A
K
S
GEGVKPSPAQ
L
-------------
E
L
R
M
V
Q
S
K
K
D
I
E
S
P
E
I
V
V
Q
A
T
V
L
17
PsiBlast_PDB
75.39
29%
-112
- C4 -
4EOH
9
PDXK_HUMAN
A:
[4-312]
---
E
C
R
V
L
S
I
Q
S
H
V
I
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
I
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
A
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
E
G
L
R
-
L
N
N
M
N
K
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
L
G
D
K
W
D
G
--
E
G
S
---
M
Y
V
P
E
--
D
L
L
P
V
Y
K
----
E
K
V
V
P
L
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
S
G
R
K
I
H
S
Q
E
E
A
L
R
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
D
L
P
S
P
Q
G
S
N
Y
----
L
I
-----
V
L
G
-
S
Q
-------
R
R
-V
V
-----
M
E
R
I
R
M
D
-
I
-
R
-
K
V
D
A
V
F
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
T
L
H
H
V
L
Q
R
T
I
Q
C
A
-------------
K
A
Q
A
GEG
V
R
P
S
PMQ
L
-------------
E
L
R
M
V
Q
S
K
R
D
I
E
D
P
E
I
V
V
Q
A
T
V
L
8
PsiBlast_PDB
74.22
33%
-113
- C4 -
1YGJ
1
PDXK_SHEEP
A:
[4-312]
---
E
C
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
S
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
D
G
L
K
-
L
N
H
V
N
Q
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
M
G
D
Q
--
R
--
N
G
E
----
G
A
M
Y
V
P
D
D
L
---
L
P
V
Y
R
E
K
V
V
P
V
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
T
G
R
K
I
H
S
Q
E
E
A
L
E
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
N
L
L
S
P
R
G
S
D
Y
L
M
--
A
L
G
S
Q
RT
R
A
P
-
D
G
-------
S
V
V
-------
T
Q
R
I
R
M
E
-
M
-
H
-
K
V
D
A
V
F
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
A
M
H
H
V
L
Q
R
T
I
K
C
A
-------------
K
A
K
S
GEG
V
K
P
S
PAQ
L
-------------
E
L
R
M
V
Q
S
K
K
D
I
E
S
P
E
I
V
V
Q
A
T
V
L
5
PsiBlast_PDB
74.14
33%
-109
- C4 -
1RFT
4
PDXK_SHEEP
A:
[4-312]
---
E
C
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
S
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
D
G
L
K
-
L
N
H
V
N
Q
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
M
G
D
Q
--
R
--
N
G
E
----
G
A
M
Y
V
P
D
D
L
---
L
P
V
Y
R
E
K
V
V
P
V
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
T
G
R
K
I
H
S
Q
E
E
A
L
E
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
N
L
L
S
P
R
G
S
D
Y
L
M
--
A
L
G
S
Q
R
T
R
A
P
-
D
G
-------
S
V
V
-------
T
Q
R
I
R
M
E
-
M
-
H
-
K
V
D
A
V
F
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
A
M
H
H
V
L
Q
R
T
I
K
C
A
-------------
K
A
K
S
GEGVKPSPAQ
L
-------------
E
L
R
M
V
Q
S
K
K
D
I
E
S
P
E
I
V
V
Q
A
T
V
L
9
PsiBlast_PDB
71.85
33%
-109
- C4 -
1YGK
1
PDXK_SHEEP
A:
[4-312]
---
E
C
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
Y
S
H
W
K
G
Q
V
L
N
S
D
E
L
Q
E
L
Y
D
G
L
K
-
L
N
H
V
N
Q
Y
D
Y
V
L
T
G
Y
T
R
D
K
S
F
L
A
M
V
V
D
I
V
Q
E
L
K
Q
Q
N
P
R
L
V
Y
V
C
D
P
V
M
G
D
Q
--
R
--
N
G
E
----
G
A
M
Y
V
P
D
D
L
---
L
P
V
Y
R
E
K
V
V
P
V
A
D
I
I
T
P
N
Q
F
E
A
E
L
L
T
G
R
K
I
H
S
Q
E
E
A
L
E
V
M
D
M
L
H
S
M
G
P
D
T
V
V
I
T
S
S
N
L
L
S
P
R
G
S
D
Y
L
M
--
A
L
G
S
Q
R
T
R
A
P
-
D
G
-------
S
V
V
-------
T
Q
R
I
R
M
E
-
M
-
H
-
K
V
D
AVF
V
-----
G
T
G
D
L
F
A
A
M
L
L
A
W
T
H
K
H
P
N
N
L
K
V
A
C
E
K
T
V
S
A
M
H
H
V
L
Q
R
T
I
K
C
A
-------------
K
AKSGE
G
V
K
P
S
PAQ
L
-------------
E
L
R
M
V
Q
S
K
K
D
I
E
S
P
E
I
V
V
Q
A
T
V
L
10
PsiBlast_PDB
69.94
33%
-104
- C4 -
1YHJ
1
PDXK_SHEEP
A:
[6-312]
-----
R
V
L
S
I
Q
S
H
V
V
R
G
Y
V
G
N
R
A
A
T
F
P
L
Q
V
L
G
F
E
V
D
A
V
N
S
V
Q
F
S
N
H
T
G
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