@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : D4MJE0_9FIRM: (2019-01-27 )
MNEIKLGKKISEGKTVDVYESGDLAVKVFKPDAPKTVVFYEAFMDSKVEETGLNVPKIKEVELIDGKWAIATELIKGKTLAQIMQEEPENCDGYLDDMVELQLSIHAKKVTGISKLKDKLREEIESLDVIDHIKRYDLLTRLDSTPKHVKLCHGNFGPENIVVTDDNKVYIVDWIGASAGNASADVAKTYLKLALTSTETAEKYLNLFCKKTNTAKTYVQEWLPIMAASTLAKGVTSKEEKDLLFTWLDVVDYS
Atome Classification :
(20 SA)
-------------------------.......---..10....-....20--.----.----------.------......30.--.-----...--...40........50.---.....---...60.-----.-.---.---..----..70........80..-..----------.-----...90........100-.-.......110----..------.--.----------.---------.----.----..120--..-------.-----------..------.-----.-----.---130--.---..----......140--.-------..---.------..--...150---------........160...---..--.-.-170..--------------------....-----------.180-.........190...-------.--------.--.-------------.200.......210...--..-...-----220.......230....------...-----240-.........250..-------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------MNEIKLG---KKISEG
K
T
-
V
D
V
YE---S----G----------
D
------
L
A
V
K
V
FKPD--A-----P
K
T
--
V
V
F
Y
E
A
F
MDS
K
V
E
E-T---GLNVP---K
I
K
E
V
E
-----L-I---D---G
K
----
W
A
I
A
T
E
L
IK
G
K
T
L
A
Q
I
-
M
Q
----------E-----EPENC
D
G
Y
L
D
D
M
V
E
L
--
Q
-
L
S
I
H
A
K
KV------T
G
------
I
--
S
----------
K
---------
L
----
K
----
D
K
L
R
---
E
E
-------
I
-----------
E
S
------
L
-----
D
-----
V
---
I
----
D
---
H
I
----
K
R
Y
D
L
L
T
----R-------LD---S------TP--
K
H
V
K
L
----------CHGNFGP
E
N
I
V
V
TD---D
N
--
K
-
V
-
Y
I
V
D
W
--------------------IGAS-----------AG---NA
S
A
D
V
A
K
T
Y
L
K
L
AL-------T--------S--
T
-------------
E
T
A
E
K
Y
L
N
L
F
CK-KTN
T
--
A
K
-
T
Y
V
-----
Q
E
W
L
P
I
M
A
A
S
T
L
A
KGVT------S
K
E
-----E---K
D
L
L
F
T
W
L
D
VVDYS-------------------------
51
HHSearch
76.51
19%
10
- C3 -
-
4H05
-
?
A:
[14-251]
---------------------------
G
C
E
W
V
---
V
V
E
D
G
A
S
G
-
A
G
V
Y
R
---
L
----
R
----------
G
GG
R
E
--
L
F
V
K
V
A
A
L
G
--------
A
G
V
--
G
L
L
G
E
A
E
R
L
V
W
L
A
E
-
V
---
G
I
P
V
P
---
R
V
V
E
G
G
-----
G
-
D
---
E
---
R
V
----
A
W
L
V
T
E
A
V
P
G
R
P
A
S
A
R
-
W
P
-----------------
R
E
Q
R
L
D
V
A
V
A
L
A
G
L
--
A
-
R
S
L
H
A
L
D
W
------
E
R
------
C
--
P
FDRS
L
A
V
T
V
P
Q
---------
A
----
A
----
R
A
V
A
---
E
G
-------
S
-----------
V
D
------
L
-----
E
-----
D
---
L
DEER
K
---
G
W
----
S
G
E
R
L
L
A
----
E
-------
L
E
---
R
T
RP---
A
D
--
E
D
L
A
V
----------
C
H
G
D
L
C
P
D
N
V
L
L
D
P
---
R
T
CE
V
-
T
-
G
L
I
D
V
--------------------
G
R
V
G
-----------
R
A
---
D
R
H
S
D
L
A
L
V
L
R
E
L
A
H
-------
E
EDPWF---
G
--
P
-------------
E
C
S
A
A
F
L
R
E
Y
G
R
-
G
W
D
G
--
A
------------------------------------------------------------------------------------
50
HHSearch
75.58
19%
6
- C3 -
-
4H05
-
?
B:
[14-251]
---------------------------
G
C
E
W
V
---
V
V
E
D
G
A
S
G
-
A
G
V
Y
R
---
L
----
R
----------
G
GG
R
E
--
L
F
V
K
V
A
A
L
G
--------
A
G
V
--
G
L
L
G
E
A
E
R
L
V
W
L
A
E
-
V
---
G
I
P
V
P
---
R
V
V
E
G
G
-----
G
-
D
---
E
---
R
V
----
A
W
L
V
T
E
A
V
P
G
R
P
A
S
A
R
-
W
P
-----------------
R
E
Q
R
L
D
V
A
V
A
L
A
G
L
--
A
-
R
S
L
H
A
L
D
W
------
E
R
------
C
--
P
FDRS
L
A
V
T
V
P
Q
---------
A
----
A
----
R
A
V
A
---
E
G
-------
S
-----------
V
D
------
L
-----
E
-----
D
---
L
DEER
K
---
G
W
----
S
G
E
R
L
L
A
----
E
-------
L
E
---
R
T
RP---
A
D
--
E
D
L
A
V
----------
C
H
G
D
L
C
P
D
N
V
L
L
D
P
---
R
T
CE
V
-
T
-
G
L
I
D
V
--------------------
G
R
V
G
-----------
R
A
---
D
R
H
S
D
L
A
L
V
L
R
E
L
A
H
-------
E
EDPWF---
G
--
P
-------------
E
C
S
A
A
F
L
R
E
Y
G
R
-
G
W
D
G
--
A
------------------------------------------------------------------------------------
68
SP3
70.52
16%
25
- C3 -
-
1O6Y
1
PKNB_MYCTU
A:
[23-298]
--------------------TPSHL
S
D
R
Y
E
L
G
---
E
I
L
G
F
G
G
M
-
S
E
V
H
L
---
A
----
R
----------
D
LRLH
R
D
V
A
V
K
V
L
R
A
D
--
L
-----
A
R
D
--
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
-
A
---
A
L
N
H
P
AIV
A
V
Y
D
T
G
-----
E
-
A
---
E
---
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
-
V
H
----------
T
EGPM-
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
--
L
-
N
F
S
H
Q
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
I
----------
I
H
R
D
V
K
P
A
N
I
M
I
S
A
---
T
N
--
A
-
V
-
K
V
M
D
F
--------------------
G
I
A
R
AIAQYLS
P
E
Q
A
R
G
DSV
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
GEPP
F
--------
T
--
G
-------------
D
S
P
V
S
V
A
Y
Q
H
V
R
-
E
D
P
I
--
P
P
-
S
A
R
-----
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
KNPENR
Y
Q
T
-----
A
---
A
E
M
R
A
D
L
V
R
V
H
N
---------------------------
57
HHSearch
69.50
15%
22
- C3 -
-
3TDW
1
?
A:
[22-278]
-----------------------------
Q
S
V
---
E
S
L
G
E
G
F
R
-
N
Y
A
I
L
---
V
----
N
----------
G
D-----
W
V
F
R
F
P
K
S
Q
--
Q
-----
G
A
D
--
E
L
N
K
E
I
Q
L
L
P
L
L
V
G
-
C
V--
K
V
N
I
P
---
Q
Y
V
Y
I
G
-----
K
R
S
---
D
---
G
N
----
P
F
V
G
Y
R
K
V
Q
G
Q
I
L
G
E
D
-
G
M
A
V
--------
L
-----
P
D
D
A
K
D
R
L
A
L
Q
L
A
E
F
--
M
-
N
E
L
S
A
F
P
V
------
E
T
------
A
--
I
S
A
G
V
P
V
T
---
N
---------
L
----
K
----
N
K
I
L
---
L
L
-------
S
-----------
E
A
------
V
E
D
QVF
P
-----
L
---
L
----
D
---
E
S
----
L
R
D
Y
L
T
L
R
F
Q
S
Y
-------
M
T
HPV
Y
------
T
R
--
Y
T
P
R
L
----------
I
H
G
D
L
S
P
D
H
F
L
T
N
L
NSR
Q
T
--
P
L
T
-
G
I
I
D
F
--------------------
G
D
A
A
-----------
I
S
---
D
P
D
Y
D
Y
V
Y
L
L
E
D
C
G
--------------------
E
--------------
L
F
T
R
Q
V
M
A
Y
R
G
-
E
V
D
L
D
T
H
I
-
R
K
V
-----
S
L
F
V
T
F
D
Q
V
S
Y
L
L
E
G
L
----------------------------------------------------------
36
Fugue
67.68
14%
26
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
SAFT
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
GIRVD
S
G
L
T
P
L
N
---
S
Y
E
N
R
V
Y
Q
-
F
Q
D
E
D
---
R
----
R
----------
R
------
F
V
V
K
F
Y
R
P
E
--
R
W----
T
A
D
--
Q
I
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
---
E
V
P
V
A
---
A
P
V
A
F
N
GQT
L
L
N
-
H
---
Q
---
G
F
----
Y
F
A
V
F
P
S
V
G
G
R
Q
F
E
A
D
-
N
I
----------
D
-----
Q
M
E
A
V
G
R
Y
L
G
R
M
H
Q
T
G
R
K
-
Q
L
F
I
H
R
P
T
------
I
G
------
L
--
N
----------
E
---------
Y
----
L
----
I
E
P
R
---
K
L
-------
F
-----------
E
D
------
A
-----
T
-----
L
---
I
----
P
---
S
G
----
L
K
A
A
F
L
K
----
A
-------
T
D
---
E
------
L
I
--
A
A
V
T
A
H
WRED
F
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
-----
R
D
--
G
-
P
-
M
F
V
D
L
--------------------
D
D
A
R
-----------
N
G
---
P
A
V
Q
D
L
W
M
L
L
N
G
D
K
A
-------
E
--------
Q
--
R
-------------
M
Q
L
E
T
I
I
E
A
Y
E
E
-
F
S
E
F
--
D
T
-
A
E
I
-----
G
L
I
E
P
L
R
A
M
R
L
V
Y
Y
L
A
W
------
L
M
R
R
WAD
P
A
---
F
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY
63
SP3
66.76
12%
16
- C3 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
--------------------GSPAA
W
V
E
R
L
F
G
Y
D
W
A
Q
Q
T
I
G
C
S
D
A
A
V
F
R
---
L
S
A
Q
G
R
----------
P
------
V
L
F
V
K
T
D
L
S
--
G
-----
A
L
N
--
E
L
Q
D
E
A
A
R
L
S
W
L
A
T
-
T
---
G
V
P
C
A
---
A
V
L
D
V
V
-----
T
-
E
---
A
---
G
R
----
D
W
L
L
L
G
E
V
P
G
Q
D
L
L
S
S
-
H
L
----------
A
---------
P
A
E
K
V
S
I
M
A
D
A
--
M
-
R
R
L
H
T
L
D
P
ATCPFD
H
Q
------
A
--
K
----------
H
---------
R
----
I
----
E
R
A
R
---
T
R
-------
M
E
A
GLVDQDDLD
E
E
------
H
-----
Q
-----
G
---
L
----
A
---
P
A
----
E
L
F
A
R
L
K
----
A
-------
R
M
---
P
------
D
G
--
E
D
L
V
V
----------
T
H
G
D
A
C
L
P
N
I
M
V
E
N
---
G
R
--
F
-
S
-
G
F
I
D
C
--------------------
G
R
L
G
-----------
V
A
---
D
R
Y
Q
D
I
A
L
A
T
R
D
I
A
E
E
------
L
--------
G
--
G
-------------
E
W
A
D
R
F
L
V
L
Y
-
G
-
I
A
A
P
--
D
S
-
Q
R
I
-----
A
F
Y
R
L
L
D
E
F
F
----------------------------------------------------------------
53
HHSearch
64.66
16%
48
- C3 -
-
4GKI
1
?
C:
[27-255]
----------------------------
Y
R
W
A
---
R
D
N
V
G
Q
S
G
-
A
T
I
Y
R
---
L
----
Y
----------
G
KPNA
P
E
L
F
L
K
H
G
K
G
S
--------
V
A
N
--
D
V
T
D
E
M
V
R
L
N
W
L
T
A
-----
F
M
P
L
P
---
T
I
K
H
F
I
-----
R
-
T
---
P
---
D
D
----
A
W
L
L
T
T
A
I
P
G
K
T
A
F
Q
V
-
L
E
----------
E
-----
Y
P
D
S
G
E
N
I
V
D
A
L
A
V
F
--
L
-
R
R
L
H
S
I
P
V
------
C
N
------
C
--
P
----------
F
NSD
R
V
F
R
--
L
----
A
----
Q
A
Q
S
---
R
M
-------
N
-----------
N
G
------
L
VDA--
S
-----
D
F--
D
----
D
ERN
G
W
----
P
V
E
Q
V
W
K
----
E
-------
M
H
---
K
L
LP---
F
S
--
P
D
S
V
V
----------
T
H
G
D
F
S
L
D
N
L
I
F
D
E
---
G
K
--
L
-
I
-
G
C
I
D
V
--------------------
G
R
V
G
-----------
I
A
---
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
E
-------
F
--------
S
--
P
-------------
S
L
Q
K
R
L
F
Q
K
Y
G
I
-
D
------------------------------------------------------------------------------------------
43
HHSearch
64.32
14%
29
- C- -
-
3N4U
-
?
A:
[23-278]
-----------------------------
N
T
I
---
E
I
S
G
E
G
N
D
-
C
I
A
Y
E
---
I
----
N
----------
R
D-----
F
I
F
K
F
P
K
H
S
--
R
-----
G
S
T
--
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
---
P
L
P
I
P
---
E
V
V
F
T
G
-----
M
-
P
---
S
ETY
Q
M
----
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
-
L
L
----------
N
N
L---
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
--
L
-
S
E
L
H
S
I
N
I
------
S
G
------
F
--
K
SNLVL-----
D
---------
F
----
R
----
E
K
I
N
---
E
D
-------
N
-----------
K
K
------
I
-----
K
K
L
L
S
R
E
---
L
----
K
---
G
P
----
Q
M
K
K
V
D
D
----
F
Y
R
D
I
L
E
N
E
I
---
Y
------
F
K
--
Y
Y
P
C
L
----------
I
H
N
D
F
S
S
D
H
I
L
F
D
T
EK-
N
T
--
I
-
C
-
G
I
I
D
F
--------------------
G
D
A
A
-----------
I
S
---
D
P
D
N
D
F
I
S
L
M
E
D
D
E
E
-------
Y
--------
G
--
M
-------------
E
F
V
S
K
I
L
N
H
Y
K
H
-
K
D
I
P
--
T
V
L
E
K
Y
-----
R
M
K
E
K
Y
W
S
F
E
K
I
I
Y
------------------------------------------------------------
55
HHSearch
64.10
15%
16
- C3 -
-
3ATS
1
Y3168_MYCTU
A:
[28-317]
------------------------------------
V
D
S
T
G
M
S
-
S
E
T
I
I
---
L
----
T
A
R
W
Q
Q
DG
R
S
I
Q
Q
K
----
L
V
A
R
V
A
P
A
A
--
E
DVPVF
P
T
Y
--
R
L
D
H
Q
F
E
V
I
R
L
V
G
E
L
T
---
D
V
P
V
P
---
R
V
R
W
I
E
-----
T
-
T
GDV
L
---
G
T
----
P
F
F
L
M
D
Y
V
E
G
V
V
P
P
D
V
-
M
P
YTFGDNWFAD
A
-----
P
A
E
R
Q
R
Q
L
Q
D
A
T
V
A
A
--
L
-
A
T
L
H
S
I
P
N
------
A
Q
------
N
T
F
S
FLT----------------------
D
----
T
T
L
H
---
R
H
F
N
W
V
R
S
W
Y
-----------
D
F
------
A
-----
V
E
G
---
I
---
G
----
R
---
S
P
----
L
L
E
R
T
F
E
----
W
-------
L
Q
---
S
H
WP
D
D
A
A
A
--
R
E
P
V
L
----------
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
---
F
Q
--
P
-
V
-
A
V
L
D
W
--------------------
E
M
V
A
-----------
L
G
---
P
R
E
L
D
V
A
W
M
I
F
A
H
R
V
-------
F
--------
Q
--
E
L
A
G
L
A
TLPGLPEV
M
R
E
D
D
V
R
A
T
Y
Q
A
-
L
T
G
V
--
E
L
-
G
D
L
-----
H
W
F
Y
V
Y
S
G
V
M
W
A
--------------------------------------------------------------
44
HHSearch
63.68
17%
44
- C3 -
-
5IQC
2
AACA_STAAU
A:
[29-257]
-----------------------------
D
S
I
---
E
I
I
G
S
G
Y
D
-
S
V
A
Y
L
---
V
----
N
----------
N
E
-----
Y
I
F
K
T
K
F
S
T
--
N
-----
K
K
K
--
G
Y
A
K
E
K
A
I
Y
N
F
L
N
T
-
N
LET
N
V
K
I
P
---
N
I
E
Y
S
Y
-----
I
-
S
---
D
---
E
L
----
S
I
L
G
Y
K
E
I
K
G
T
F
L
T
P
E
-
I
Y
----------
S
T
M---
S
E
E
E
Q
N
L
L
K
R
D
I
A
S
F
--
L
-
R
Q
M
H
G
L
D
Y
------
T
D
------
I
--
S
ECTID-----
N
---------
K
----
Q
----
N
V
L
E
E
Y
I
L
L
-------
R
-----------
E
T
------
I
Y----
N
-----
D
---
L
----
T
D
I
E
K
D
----
Y
I
E
S
F
M
E
----
R
-------
L
N
---
A
TTV---
F
E
--
G
K
K
C
L
----------
C
H
N
D
F
S
C
N
H
L
L
L
D
G
---
N
N
--
R
-
L
T
G
I
I
D
F
--------------------
G
D
S
G
-----------
I
I
---
D
E
Y
C
D
F
I
Y
L
L
E
D
S
E
E
-------
E
--------
I
G-
T
-------------
N
F
G
E
D
I
L
R
M
Y
G
N
--------------------------------------------------------------------------------------------
42
HHSearch
63.59
17%
47
- C3 -
-
5IQI
1
AACA_STAAU
C:
[29-257]
-----------------------------
D
S
I
---
E
I
I
G
S
G
Y
D
-
S
V
A
Y
L
---
V
----
N
----------
N
E
-----
Y
I
F
K
T
K
F
S
T
--
N
-----
K
K
K
--
G
F
A
K
E
K
A
I
Y
N
F
L
N
T
-
N
LET
N
V
K
I
P
---
N
I
E
Y
S
Y
-----
I
-
S
---
D
---
E
L
----
S
I
L
G
Y
K
E
I
K
G
T
F
L
T
P
E
-
I
Y
----------
S
T
M---
S
E
E
E
Q
N
L
L
K
R
D
I
A
S
F
--
L
-
R
Q
M
H
G
L
D
Y
------
T
D
------
I
--
S
ECTID-----
N
---------
K
----
Q
----
N
V
L
E
---
E
Y
-------
I
-----------
L
L
------
R
E
TIY-
N
-----
D
---
L
T
D
I
-
E
---
K
D
----
Y
I
E
S
F
M
E
----
R
-------
L
N
---
A
TTV---
F
E
--
G
K
K
C
L
----------
C
H
N
D
F
S
C
N
H
L
L
L
D
G
---
N
N
--
R
L
T
-
G
I
I
D
F
--------------------
G
D
S
G
-----------
I
I
---
D
E
Y
C
D
F
I
Y
L
L
E
D
S
E
E
-------
E
--------
I
G-
T
-------------
N
F
G
E
D
I
L
R
M
Y
G
N
--------------------------------------------------------------------------------------------
52
HHSearch
63.22
16%
57
- C3 -
-
4GKH
2
?
A:
[27-255]
----------------------------
Y
R
W
A
---
R
D
N
V
G
Q
S
G
-
A
T
I
Y
R
---
L
----
Y
----------
G
KPN
A
P
E
L
F
L
K
H
G
K
G
S
--------
V
A
N
--
D
V
T
D
E
M
V
R
L
N
W
L
T
A
-----
F
M
P
L
P
---
T
I
K
H
F
I
-----
R
-
T
---
P
---
D
D
----
A
W
L
L
T
T
A
I
P
G
K
T
A
F
Q
V
-
L
E
----------
E
-----
Y
P
D
S
G
E
N
I
V
D
A
L
A
V
F
--
L
-
R
R
L
H
S
I
P
V
------
C
N
------
C
--
P
----------
F
NSD
R
V
F
R
--
L
----
A
----
Q
A
Q
S
---
R
M
-------
N
-----------
N
G
------
L
VDA--
S
-----
D
F--
D
----
D
ERN
G
W
----
P
V
E
Q
V
W
K
----
E
-------
M
H
---
K
L
L
P
---
F
S
--
P
D
S
V
V
----------
T
H
G
D
F
S
L
D
N
L
I
F
D
E
---
G
K
--
L
-
I
-
G
C
I
D
V
--------------------
G
R
V
G
-----------
I
A
---
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
E
-------
F
--------
S
--
P
-------------
S
L
Q
K
R
L
F
Q
K
Y
G
I
-
D
------------------------------------------------------------------------------------------
49
HHSearch
63.18
15%
23
* C3 *
-
1ND4
1
KKA2_KLEPN
A:
[24-259]
------------------------------
W
A
---
Q
Q
T
I
G
C
S
D
-
A
A
V
F
R
---
L
----
S
----------
A
Q
G
R
P
V
-
L
F
V
K
T
D
L
S
G
--------
A
L
N
--
E
L
Q
D
E
A
A
R
L
S
W
L
A
T
-
T
---
G
V
P
C
A
---
A
V
L
D
V
V
-----
T
-
E
---
A
---
G
R
----
D
W
L
L
L
G
E
V
P
G
Q
D
L
L
S
S
-
H
L
----------
A
---------
P
A
E
K
V
S
I
M
A
D
A
--
M
-
R
R
L
H
T
L
D
P
------
A
T
------
C
--
P
FDHQ
A
K
H
R
I
E
R
---------
A
----
R
----
T
R
M
E
---
A
G
-------
L
-----------
V
D
------
Q
-----
D
-----
D
---
L
DEEH
Q
---
G
L
----
A
P
A
E
L
F
A
----
R
-------
L
K
---
A
R
MP---
D
G
--
E
D
L
V
V
----------
T
H
G
D
A
C
L
P
N
I
M
V
E
N
---
G
R
--
F
-
S
-
G
F
I
D
C
--------------------
G
R
L
G
-----------
V
A
---
D
R
Y
Q
D
I
A
L
A
T
R
D
I
A
E
E
------
L
--------
G
--
G
-------------
E
W
A
D
R
F
L
V
L
Y
G
I
-
A
-
A
P
--
D
S
-
Q
R
I
-----
A
F
Y
R
L
---------------------------------------------------------------------
54
HHSearch
62.16
15%
13
- C3 -
-
3ATT
2
Y3168_MYCTU
A:
[28-317]
------------------------------------
V
D
S
T
G
M
S
-
S
E
T
I
I
---
L
----
T
A
R
W
Q
Q
DG
R
S
I
Q
Q
K
----
L
V
A
R
V
A
P
A
A
--
E
DVPVF
P
T
Y
--
R
L
D
H
Q
F
E
V
I
R
L
V
G
E
L
T
---
D
V
P
V
P
---
R
V
R
W
I
E
-----
T
-
T
GDV
L
---
G
T
----
P
F
F
L
M
D
Y
V
E
G
V
V
P
P
D
V
-
M
P
YTFGDNWFAD
A
-----
P
A
E
R
Q
R
Q
L
Q
D
A
T
V
A
A
--
L
-
A
T
L
H
S
I
P
N
------
A
Q
------
N
T
F
S
FLT----------------------
D
----
T
T
L
H
---
R
H
F
N
W
V
R
S
W
Y
-----------
D
F
------
A
-----
V
E
G
---
I
---
G
----
R
---
S
P
----
L
L
E
R
T
F
E
----
W
-------
L
Q
---
S
H
WP
D
D
A
A
A
--
R
E
P
V
L
----------
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
---
F
Q
--
P
-
V
-
A
V
L
D
W
--------------------
E
M
V
A
-----------
L
G
---
P
R
E
L
D
V
A
W
M
I
F
A
H
R
V
-------
F
--------
Q
--
E
L
A
G
L
A
TLPGLPEV
M
R
E
D
D
V
R
A
T
Y
Q
A
-
L
T
G
V
--
E
L
-
G
D
L
-----
H
W
F
Y
V
Y
S
G
V
M
W
A
--------------------------------------------------------------
71
SP3
59.72
15%
19
- C3 -
-
1UWH
1
BRAF_HUMAN
A:
[1-276]
-------------------DDWEIP
D
G
Q
I
T
V
G
---
Q
R
I
G
S
G
S
F
-
G
T
V
Y
K
G
K
W
H
----
G
----------
D
------
V
A
V
K
M
L
N
V
T
--
A
-----
P
T
P
--
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
-
K
----
T
R
H
V
---
N
I
L
L
F
M
-----
G
-
Y
ST-
A
---
P
Q
----
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
-
L
H
----------
I
IE
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
--
M
-
D
Y
L
H
A
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
I
----------
I
H
R
D
L
K
S
N
N
I
F
L
H
E
---
D
L
--
T
-
V
-
K
I
G
D
F
GLATVLSGSILWMA
P
E
V
I
R
M
Q
D
K
N
-----------
P
Y
---
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
-------
L
M
T
GQLPYS
N
--
I
-------------
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
--
D
L
-
S
K
V
RSNCP
K
A
M
K
R
L
M
A
E
C
----
L
K
K
------
K
R
D
-----
E
RPL
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
LPK----------------------
61
HHSearch
59.60
15%
43
- C3 -
-
4DCA
1
?
A:
[41-278]
------------------------------
E
L
---
R
Y
L
S
S
G
D
D
-
S
D
T
F
L
---
C
----
N
----------
E
Q-----
Y
V
V
K
V
P
K
R
D
--
S
-----
V
R
I
--
S
Q
K
R
E
L
E
L
Y
R
F
L
E
N
-
C
KL-
S
Y
Q
I
P
---
A
V
V
Y
Q
----------------
S
D
----
R
F
N
I
M
K
Y
I
K
G
E
R
I
T
Y
E
Q
Y
H
----------
K
L----
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
--
L
-
K
E
L
H
S
I
E
I
------
D
C
------
S
--
V
----------
S
L
F
S
D
A
LVN
K
K
----
D
----
K
F
L
Q
D
K
K
L
L
-------
I
-----------
S
I
------
L
E
K
E
--
Q
-----
L
---
L
----
T
---
D
E
M
L
E
-
H
I
E
T
I
Y
E
----
N
-------
I
L
---
S
NAVL--
F
K
--
Y
T
P
C
L
----------
V
H
N
D
F
S
A
N
N
M
I
F
R
N
---
N
R
--
L
-
F
-
G
V
I
D
F
--------------------
G
D
F
N
-----------
V
G
---
D
P
D
N
D
F
L
C
L
L
D
C
S
T
D
-------
D
--------
F
G-
K
-------------
E
F
G
R
K
V
L
K
Y
Y
Q
H
-
K
A
P
E
--
V
A
-
E
R
K
-------------------------------------------------------------------------------
64
SP3
59.46
14%
81
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
-------------AKMRIS
P
E
L
K
K
L
I
E
K
Y
R
C
V
---
K
D
T
E
G
M
S
P
-
A
K
V
Y
K
---
L
V
G
EN
E
----------
N
------
L
Y
L
K
M
T
D
S
R
--
Y
-----
K
G
T
TY
D
V
E
R
E
K
D
M
M
L
W
L
-
E
-
G
---
K
L
P
V
P
---
K
V
L
H
F
E
-----
R
-
H
---
D
---
G
W
----
S
N
L
L
M
S
E
A
D
G
V
L
C
S
E
E
--
Y
----------
E
-----
D
E
Q
S
P
E
K
I
I
E
L
Y
A
E
C
--
I
-
R
L
F
H
S
I
D
I
------
S
D
CPYTNS
L
--
D
----------
S
---------
R
----
L
----
A
E
L
D
---
Y
L
-------
L
-----------
N
N
DLADVD
C
-----
E
-----
N
---
W
----
E
---
E
D
TPFK
D
P
R
E
L
Y
D
----
F
-------
L
K
---
T
------
E
K
P
E
E
E
L
V
F
----------
S
H
G
D
L
G
D
S
N
I
F
V
K
D
---
G
K
--
V
-
S
-
G
F
I
D
L
--------------------
G
R
S
G
-----------
R
A
---
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
E
-------
D
IG------
E
--
E
-------------
Q
Y
V
E
L
F
F
D
L
L
---
G
I
K
P
--
D
W
-
E
K
I
-----
K
Y
Y
I
L
L
D
E
L
F
----------------------------------------------------------------
38
Fugue
59.40
17%
-8
- C3 -
-
4WW7
1
BUD32_YEAST
A:
[4-257]
-------------------------
E
F
I
D
K
V
S
---
S
Y
L
T
P
D
V
D
-
I
A
P
I
S
---
Q
----
G
------------------
A
A
I
V
F
T
T
T
--
T
--------------
H
P
Y
L
P
R
A
K
D
S
-
H
---
Q
K
Y
I
I
---
K
Y
R
P
R
T
-----
L
-
N
---
E
---
S
R
----
L
L
A
K
L
Y
L
I
P
G
L
C
V
P
Q
L
-
I
A
----------
C
-----
D
P
Y
N
------
G
F
I
W
L
--
E
F
L
G
E
D
L
P
G
G
------
H
G
------
F
--
S
----------
N
---------
L
----
K
----
N
F
L
W
---
M
H
-------
D
-----------
Q
D
------
P
-----
Y
-----
S
---
D
----
L
---
V
A
----
T
T
L
R
K
V
G
----
R
-------
Q
I
---
G
------
L
L
--
H
W
N
D
Y
----------
C
H
G
D
L
T
S
S
N
I
V
L
V
R
---
D
G
--
A
-
R
-
W
T
P
H
L
--------------------
I
D
F
G
-----------
L
G
---
S
V
S
N
L
V
E
D
K
G
V
D
L
Y
V
-------
L
--------
E
--
R
-------------
A
I
L
S
T
H
S
----
K
-
H
A
E
K
--
Y
N
-
A
W
I
-----
M
E
G
F
E
E
V
Y
R
E
Q
G
A
K
G
A
K
------
K
L
K
-----
E
---
V
T
K
R
F
E
E
V
R
L
R
G
R
K
R------------------------
46
HHSearch
59.34
17%
67
- C3 -
-
3TM0
2
KKA3_ENTFL
A:
[15-246]
---------------------------
K
Y
R
C
V
---
K
D
T
E
G
M
S
P
-
A
K
V
Y
K
---
L
----
V
----------
G
EN
E
N
--
L
Y
L
K
M
T
D
S
R
YK
G
-----
T
T
Y
--
D
V
E
R
E
K
D
M
M
L
W
L
E
G
-----
K
L
P
V
P
---
K
V
L
H
F
E
-----
R
-
H
---
D
---
G
W
----
S
N
L
L
M
S
E
A
D
G
V
L
C
S
E
E
-
Y
E
----------
D
------
E
Q
S
P
E
K
I
I
E
L
Y
A
E
C
--
I
-
R
L
F
H
S
I
D
I
------
S
D
------
C
--
P
YTNS
L
D
----
S
---------
R
----
L
A
E
L
D
Y
L
L
N
---
N
D
-------
L
-----------
A
D
------
V
-----
D
CEN--
W
---
E
EDT-
P
---
F
K
----
D
P
R
E
L
Y
D
----
F
-------
L
K
---
T
E
K----
P
E
--
E
E
L
V
F
----------
S
H
G
D
L
G
D
S
N
I
F
V
K
D
---
G
K
--
V
-
S
-
G
F
I
D
L
--------------------
G
R
S
G
-----------
R
A
---
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
E
-------
D
--------
I
GE
E
-------------
Q
Y
V
E
L
F
F
D
L
L
G
I
--------------------------------------------------------------------------------------------
47
HHSearch
59.19
17%
63
- C3 -
-
1L8T
2
KKA3_ENTFL
A:
[15-246]
---------------------------
K
Y
R
C
V
---
K
D
T
E
G
M
S
P
-
A
K
V
Y
K
---
L
----
V
----------
G
EN
E
N
--
L
Y
L
K
M
T
D
S
R
YK
G
-----
T
T
Y
--
D
V
E
R
E
K
D
M
M
L
W
L
E
G
-----
K
L
P
V
P
---
K
V
L
H
F
E
-----
R
-
H
---
D
---
G
W
----
S
N
L
L
M
S
E
A
D
G
V
L
C
S
E
E
-
Y
E
----------
D
------
E
Q
S
P
E
K
I
I
E
L
Y
A
E
C
--
I
-
R
L
F
H
S
I
D
I
------
S
D
------
C
--
P
YTNS
L
D
----
S
---------
R
L
A
E
L
D
----
Y
L
L
N
---
N
D
-------
L
-----------
A
D
------
V
-----
D
CEN--
W
EED
T
----
P
---
F
K
----
D
P
R
E
L
Y
D
----
F
-------
L
K
---
T
E
K----
P
E
--
E
E
L
V
F
----------
S
H
G
D
L
G
D
S
N
I
F
V
K
D
---
G
K
--
V
-
S
-
G
F
I
D
L
--------------------
G
R
S
G
-----------
R
A
---
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
E
-------
D
--------
I
GE
E
-------------
Q
Y
V
E
L
F
F
D
L
L
G
I
--------------------------------------------------------------------------------------------