@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H2JTW9_STRHJ: (2019-01-29 )
MGPVNTVRMREGEVGIDAPLVGRLIARQFPGWAALPVRRVDSSGTENAMFRLGTGLVVRLPRHPGAVADVTHEQRWLPRLGPLLPVATPEPAGLGAPDEDFPWPWSVYRWLDGRNPVAGAVAEPECLAERLGSFVAALRRIDPHDGPPASRGAPLATRDEPTRAALARLTGLTGLTDRIDTAAVTALWEEALRAPAHCGPPAWAHGDLSPGNVLVDGDGLGAVIDFGCAGVGDPAVDLIVAWNLLPASARDTFREAVGADDAEWARGRGWALSISLIQLPYYRHTNPALAENSRHVIAEILAEAGRR
Atome Classification :
(20 SA)
.........10........20........30.-.......40........50.----.----......60........70.....-...80..--.--.....90........100...----....110.-----......120---.-----------........130.......140...-...--.-150-.-------........---160........-.170-........180.......190-.-.--.....-200.......210....--.----..220.......230.......240..----.....250......----.-260-.....--....270....--...280...-.-...290.......300.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGPV
N
T
V
R
MREGEVGID
A
P
L
V
G
R
L
I
A
R
QFPGW-AA
L
P
V
R
RVDSSGTEN
A
M
F
RL----G----
T
G
L
V
V
RLPRHPGAVADV
T
H
E
Q
R
W
-
L
PRLGPL--L--PVATPEPAGLGAPDEDFPW
P
W
----
S
V
Y
R
WLDG-----RNPVAGA-----V-----------A
E
P
E
C
L
A
E
R
L
G
S
F
V
A
A
L
RRIDPHD-GPP--A-S---R-------GAPLATRD---
E
--
P
T
R
A
A
L
A
R
-
L
TG--LTGLTD
R
I
D
T
A
A
V
T
A
L
W
E
E
A
L
-R-A--PAHCG-PPAWAHGDLSPG
N
V
L
VD--G----DG
L
G
A
V
I
DFGCAGVGD
P
A
V
D
L
I
V
A
WNL----LPA
S
A
R
D
T
F
R
E
A
VG----A-D---
D
A
E
WA--RGR
G
W
A
L
S
I
S
L
--
I
QLPYYRHT-N-PALAEN
S
R
H
V
I
A
E
I
L
A
EAGRR
198
HHSearch
71.03
19%
-31
- C5 -
-
3TDW
1
?
A:
[4-300]
----------------
N
K
L
H
Y
T
T
M
I
M
T
Q
F
P
D
I
-
S
I
Q
S
V
E
S
L
G
-
E
G
F
R
N
Y
A
I
L
V
----
N
----
G
D
W
V
F
R
F
P
K
S
Q
Q
G
A
D
E
L
N
K
E
I
Q
L
-
L
P
L
L
V
G
C
--
V
--
K
V
N
I
P
Q
Y
V
Y
I
G
K
R
S
--
D
G
N
P
F
----
V
G
Y
R
K
V
Q
G
-----
Q
I
L
G
E
D
G
M
A
V
LP
D
-----------
D
A
K
D
R
L
A
L
Q
L
A
E
F
M
N
E
L
S
A
F
P
V
E
T
-
A
I
S
--
A
-
G
V
--
P
-------
V
T
N
L
K
N
K
I
---
L
--
L
L
S
E
A
V
E
D
Q
V
F
P
----
L
L
D
E
S
-
L
R
D
Y
L
T
L
R
F
Q
S
Y
M
-
T
-
H
P-
V
Y
T
R
Y
-
T
P
R
L
I
H
G
D
L
S
P
D
H
F
L
T
N
--
L
NSRQ
T
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
Y
L
L
E
D
----
C
G
E
L
F
T
R
-
Q
V
M
A
Y
R
GEV-
D
-
L
---
D
T
H
I
R
--
K
V
S
L
F
V
T
F
D
Q
V
--
S
Y
L
L
E
G
L
R
A
R
D
-
Q
D
W
I
S
E
G
L
E
L
L
E
E
D
K
A
N
N
---
3
PsiBlast_PDB
68.89
21%
-22
- C4 -
-
3UZR
5
?
A:
[22-276]
------------
M
V
N
L
D
A
E
I
Y
E
H
L
-----
N
K
Q
-
I
K
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
----
N
----
E
Q
Y
V
V
K
V
P
K
R
D
S
V
R
I
S
Q
K
R
E
L
E
--
L
Y
R
F
L
E
N
--
C
--
K
L
S
Y
Q
I
P
A
V
V
Y
Q
S
D
-----
R
F
----
N
I
M
K
Y
I
K
G
-----
E
R
I
T
Y
E
Q
-----
Y
H
K
LS
E
------
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
-
S
V
S
--
L
-
F
---
S
-------
D
A
L
V
N
K
K
D
K
F
L
Q
--
D
K
K
L
L
I
S
I
-
L
E
K
--
E
Q
L
L
T
D
E
M
-
L
E
H
I
E
T
I
Y
E
N
I
L
S
N
-
A
--
V
L
F
K
Y
-
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
--
N
----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
---
L
----
L
D
C
S
T
D
D
F
------------------------
G
K
E
F
G
R
K
V
------
L
K
Y
Y
Q
H
K
-
A
-
P
E
V
A
E
----------------
203
HHSearch
67.96
17%
-20
- C5 -
-
5IQI
1
AACA_STAAU
C:
[9-302]
--------------
A
T
N
V
K
A
M
K
Y
L
I
E
H
Y
F
D
N
F
-
K
V
D
S
I
E
I
I
G
-
S
G
Y
D
S
V
A
Y
L
V
----
N
----
N
E
Y
I
F
K
T
K
F
S
T
N
K
K
K
G
F
A
K
E
K
A
I
-
Y
N
F
L
N
T
N
LE
T
--
N
V
K
I
P
N
I
E
Y
S
Y
I
S
D
---
E
L
S
I
----
L
G
Y
K
E
I
K
G
-----
T
F
L
T
P
E
I
Y
S
T
MS
E
-----------
E
E
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
T
D
-
I
S
E
--
C
-
T
---
I
-------
D
-
N
K
Q
N
V
L
---
E
--
E
Y
I
L
L
R
E
T
-
I
Y
N
----
D
L
T
D
I
--
E
K
D
Y
I
E
S
F
M
E
R
L
-
N
-
A
T-
T
V
F
E
G
-
K
K
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
--
G
N---
N
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
Y
L
L
E
D
SEEE
I
G
T
N
F
G
E
D
I
L
R
M
Y
G
NI--
D
-
I
---
E
K
A
K
E
--
Y
Q
D
I
V
E
E
Y
Y
P
I
--
E
T
I
V
Y
G
I
K
N
I
K
-
Q
E
F
I
E
N
G
R
K
E
I
Y
K
R
T
------
197
HHSearch
67.74
25%
-22
- C5 -
-
5UXD
2
?
A:
[5-298]
---------------
E
D
L
D
A
L
L
D
L
A
A
R
H
G
L
D
L
-
D
G
G
T
L
R
T
E
E
-
I
G
L
D
F
R
V
A
F
A
----
R
A
HDG
G
D
W
V
L
R
L
P
R
R
P
D
V
L
E
R
A
A
V
E
G
R
L
-
L
A
M
L
A
P
H
--
L
--
D
V
A
V
P
D
W
R
I
S
T
-------
S
E
L
----
I
A
Y
P
L
L
P
G
-----
S
P
G
L
T
V
A
-----
A
DG
E
V
S
W
HVD--
M
A
S
T
V
Y
A
R
S
L
G
S
V
V
A
Q
L
H
A
V
D
A
E
A
-
A
A
A
T
-
G
-
I
---
E
-------
V
R
S
P
A
Q
V
R
---
G
--
A
W
R
Q
D
L
A
R
-
V
G
A
--
E
F
E
I
-----
A
P
A
L
R
E
R
W
E
A
W
L
-
A
-
D
D-
G
C
W
P
G
-
H
S
V
L
T
H
G
E
L
Y
P
A
H
T
L
V
E
--
D
----
E
R
I
T
A
V
L
D
W
T
T
A
A
V
G
D
P
A
K
D
L
M
F
H
Q
V
S
----
A
P
S
A
I
F
E
V
A
L
Q
A
Y
A
----
E
G
G
---
G
R
P
W
P
G
L
A
R
H
C
T
E
M
F
S
A
A
P
L
G
Y
G
L
Y
A
L
A
T
G
E
-
A
A
H
R
E
A
A
A
A
A
L
N
P
P
E
------
2
PsiBlast_PDB
67.59
21%
17
- C4 -
-
3HAV
2
?
A:
[2-258]
-------------
V
N
L
D
A
E
I
Y
E
H
L
-----
N
K
Q
-
I
K
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
----
N
----
E
Q
Y
V
V
K
V
P
K
R
D
S
V
--
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
--
C
--
K
L
S
Y
Q
I
P
A
V
V
Y
Q
S
D
-----
R
F
----
N
I
M
K
Y
I
K
G
-----
E
R
I
T
Y
E
Q
-----
Y
H
K
LS
E
------
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
-
S
V
S
--
L
-
F
---
S
-------
D
A
L
V
N
K
K
D
K
F
L
Q
--
D
K
K
L
L
I
S
I
-
L
E
K
--
E
Q
L
L
T
D
E
M
-
L
E
H
I
E
T
I
Y
E
N
I
L
-
N
N
A
--
V
L
F
K
Y
-
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
--
N
----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
---
L
----
L
D
C
S
T
D
D
F
G
K
E
F
--------------------
G
R
K
V
----------
L
K
Y
Y
Q
H
K
-
A
-
P
E
V
A
E
----------------
204
HHSearch
67.57
17%
-22
* C5 *
-
5IQC
2
AACA_STAAU
A:
[9-301]
--------------
A
T
N
V
K
A
M
K
Y
L
I
E
H
Y
F
D
N
F
-
K
V
D
S
I
E
I
I
G
-
S
G
Y
D
S
V
A
Y
L
V
----
N
----
N
E
Y
I
F
K
T
K
F
S
T
N
K
K
K
G
Y
A
K
E
K
A
I
-
Y
N
F
L
N
T
N
--
L
ET
N
V
K
I
P
N
I
E
Y
S
Y
I
S
D
---
E
L
S
I
----
L
G
Y
K
E
I
K
G
-----
T
F
L
T
P
E
I
Y
S
T
MS
E
-----------
E
E
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
T
D
-
I
S
E
--
C
-
T
---
I
-------
D
N
K
Q
N
-
V
L
---
E
--
E
Y
I
L
L
R
E
T
-
I
Y
N
----
D
L
T
D
I
--
E
K
D
Y
I
E
S
F
M
E
R
L
-
N
-
A
T-
T
V
F
E
G
-
K
K
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
G-
N
----
N
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
Y
L
L
E
D
SEEE
I
G
T
N
F
G
E
D
I
L
R
M
Y
G
NI--
D
-
I
---
E
K
A
K
E
--
Y
Q
D
I
V
E
E
Y
Y
P
I
--
E
T
I
V
Y
G
I
K
N
I
K
-
Q
E
F
I
E
N
G
R
K
E
I
Y
K
R
-------
4
PsiBlast_PDB
66.84
21%
-21
- C4 -
-
4DCA
1
?
A:
[25-276]
---------------
L
D
A
E
I
Y
E
H
L
-----
N
K
Q
-
I
K
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
----
N
----
E
Q
Y
V
V
K
V
P
K
R
D
S
V
R
I
S
Q
K
R
E
L
E
--
L
Y
R
F
L
E
N
--
C
--
K
L
S
Y
Q
I
P
A
V
V
Y
Q
S
D
-----
R
F
----
N
I
M
K
Y
I
K
G
-----
E
R
I
T
Y
E
Q
-----
Y
H
K
LS
E
------
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
-
S
V
S
--
L
-
F
---
S
-------
D
A
L
V
N
K
K
D
K
F
L
Q
--
D
K
K
L
L
I
S
I
-
L
E
K
--
E
Q
L
L
T
D
E
M
-
L
E
H
I
E
T
I
Y
E
N
I
L
S
N
-
A
--
V
L
F
K
Y
-
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
--
N
----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
---
L
----
L
D
C
S
T
D
D
F
------------------------
G
K
E
F
G
R
K
V
------
L
K
Y
Y
Q
H
K
-
A
-
P
E
V
A
E
----------------
1
PsiBlast_PDB
66.45
21%
17
- C4 -
-
3HAM
3
?
A:
[2-255]
-------------
V
N
L
D
A
E
I
Y
E
H
L
-----
N
K
Q
-
I
K
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
----
N
----
E
Q
Y
V
V
K
V
P
K
R
D
S
V
--
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
--
C
--
K
L
S
Y
Q
I
P
A
V
V
Y
Q
S
D
-----
R
F
----
N
I
M
K
Y
I
K
G
-----
E
R
I
T
Y
E
Q
-----
Y
H
K
LS
E
------
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
-
S
V
S
--
L
-
F
---
S
-------
D
A
L
V
N
K
K
D
K
F
L
Q
--
D
K
K
L
L
I
S
I
-
L
E
K
--
E
Q
L
L
T
D
E
M
-
L
E
H
I
E
T
I
Y
E
N
I
L
-
N
N
A
--
V
L
F
K
Y
-
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
--
N
----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
---
L
----
L
D
C
S
T
D
D
F
G
K
E
F
--------------------
G
R
K
V
----------
L
K
Y
Y
Q
H
K
-
A
-
P
E
V
A
E
----------------
207
HHSearch
65.43
18%
-19
- C5 -
-
4DCA
1
?
A:
[25-296]
---------------
L
D
A
E
I
Y
E
H
L
N
K
----
Q
I
-
K
I
N
E
L
R
Y
L
S
-
S
G
D
D
S
D
T
F
L
C
----
N
----
E
Q
Y
V
V
K
V
P
K
R
D
S
V
R
I
S
Q
K
R
E
L
E
L
-
Y
R
F
L
E
N
C
K-
L
--
S
Y
Q
I
P
A
V
V
Y
Q
S
-------
D
R
F
----
N
I
M
K
Y
I
K
G
-----
E
R
I
T
Y
E
Q
Y
H
K
LS
E
-----------
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
-
S
V
S
L
F
S
-
D
A
--
L
-------
V
N
K
K
D
K
F
L
---
Q
--
D
K
K
L
L
I
S
I
-
L
E
K
--
E
Q
L
L
T
D
E
--
M
L
E
H
I
E
T
I
Y
E
N
I
-
L
-
S
NA
V
L
F
K
Y
-
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
--
N
----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
C
STDD
F
G
K
E
F
G
R
K
V
L
K
Y
Y
Q
HK--
A
-
P
---
E
V
A
E
R
--
K
A
E
L
N
D
V
Y
W
S
I
--
D
Q
I
I
Y
G
Y
E
-------------------------
14
PsiBlast_PDB
63.88
18%
-11
- C4 -
-
3SG8
1
?
A:
[9-265]
--------------------
V
E
K
A
I
E
Q
L
Y
P
D
F
-
T
I
N
T
I
E
-
I
S
G
E
G
N
D
C
I
A
Y
E
I
----
N
----
R
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
-
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
----
A
G
F
T
K
I
K
G
V
P
LT
P
L
L
L
N
N
L
P
-----
K
-----------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
-
S
-
G
F
K
--
S
-
N
---
L
-------
V
L
D
F
R
E
K
I
---
N
--
E
D
N
K
K
I
K
K
-
L
L
S
RE
L
K
G
P
Q
----
M
K
K
V
D
D
F
Y
R
D
I
L
-
E
-
N
--
E
I
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
TE
K
----
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
--------------------
S
L
M
----
E
-
D
---
D
E
E
Y
----
G
M
E
F
V
S
K
I
------
L
N
H
Y
K
H
K
-
D
I
P
T
V
L
E
K
Y
R
-------------
9
PsiBlast_PDB
63.76
18%
-14
- C4 -
-
5C4L
1
?
A:
[29-285]
--------------------
V
E
K
A
I
E
Q
L
Y
P
D
F
-
T
I
N
T
I
Q
-
I
S
G
K
G
N
D
C
I
A
Y
E
I
----
N
----
R
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
-
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
----
A
G
F
T
K
I
K
G
V
P
LT
P
L
L
L
N
N
L
P
-----
K
-----------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
-
S
-
G
F
K
--
S
-
N
---
L
-------
V
L
D
F
R
E
K
I
---
N
--
E
D
N
K
K
I
K
K
-
L
L
S
RE
L
K
G
P
Q
----
M
K
K
V
D
D
F
Y
R
D
I
L
-
E
-
N
--
E
I
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
TE
K
----
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
--------------------
S
L
M
----
E
-
D
---
D
E
E
Y
----
G
M
E
F
V
S
K
I
------
L
N
H
Y
K
H
K
-
D
I
P
T
V
L
E
K
Y
R
-------------
13
PsiBlast_PDB
63.42
18%
-11
- C4 -
-
3SG9
1
?
A:
[9-265]
--------------------
V
E
K
A
I
E
Q
L
Y
P
D
F
-
T
I
N
T
I
E
-
I
S
G
E
G
N
D
C
I
A
Y
E
I
----
N
----
R
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
-
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
----
A
G
F
T
K
I
K
G
V
P
LT
P
L
L
L
N
N
L
P
-----
K
-----------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
-
S
-
G
F
K
--
S
-
N
---
L
-------
V
L
D
F
R
E
K
I
---
N
--
E
D
N
K
K
I
K
K
-
L
L
S
RE
L
K
G
P
Q
----
M
K
K
V
D
D
F
Y
R
D
I
L
-
E
-
N
--
E
I
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
TE
K
----
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
--------------------
S
L
M
----
E
-
D
---
D
E
E
Y
----
G
M
E
F
V
S
K
I
------
L
N
H
Y
K
H
K
-
D
I
P
T
V
L
E
K
Y
R
-------------
10
PsiBlast_PDB
62.92
18%
-11
- C4 -
-
6CD7
-
?
A:
[10-266]
--------------------
V
E
K
A
I
E
Q
L
Y
P
D
F
-
T
I
N
T
I
E
-
I
S
G
E
G
N
D
C
I
A
Y
E
I
----
N
----
R
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
-
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
----
A
G
F
T
K
I
K
G
V
P
LT
P
L
L
L
N
N
L
P
-----
K
-----------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
-
S
-
G
F
K
--
S
-
N
---
L
-------
V
L
D
F
R
E
K
I
---
N
--
E
D
N
K
K
I
K
K
-
L
L
S
RE
L
K
G
P
Q
----
M
K
K
V
D
D
F
Y
R
D
I
L
-
E
-
N
--
E
I
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
TE
K
----
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
--------------------
S
L
M
----
E
-
D
---
D
E
E
Y
----
G
M
E
F
V
S
K
I
------
L
N
H
Y
K
H
K
-
D
I
P
T
V
L
E
K
Y
R
-------------
211
HHSearch
62.88
15%
-11
- C5 -
-
3JR1
3
?
A:
[16-309]
------------
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
A
Y
Y
F
I
K
H
K
E
K
L
Y
-
S
G
E
M
N
E
I
W
L
I
----
N
DE
V
-
Q
T
V
F
V
K
I
N
E
R
S
-
Y
R
S
M
F
R
A
E
A
D
Q
-
L
A
L
L
A
K
T
--
N
--
S
I
N
V
P
L
V
Y
G
I
G
N
S
Q
---
G
H
S
F
----
L
L
L
E
A
L
N
K
-----
S
K
N
K
-----------------------
Q
S
S
F
T
I
F
A
E
K
I
A
Q
L
H
Q
I
Q
G
P
D
K
Y
G
L
D
F
D
-
T
W
L
G
P
I
Y
Q
P
N
D
W
Q
T
S
W
A
K
F
F
---
S
EN
R
I
G
W
Q
L
Q
I
-
C
K
E
--
K
-
G
L
I
F
G
-
N
I
D
L
I
V
Q
I
V
A
D
T
L
-
S
-----
K
H
N
P
-
K
P
S
I
L
H
G
N
L
W
I
E
N
C
I
Q
V
--
D
----
D
K
I
F
-
V
C
N
P
-
A
C
Y
W
G
D
R
E
C
D
I
A
F
S
S
L
F
----
E
--
P
F
P
T
N
F
Y
Q
R
Y
N
E
I
Y
P
L
-
E
---
E
G
Y
L
E
--
R
K
L
I
Y
Q
L
Y
Y
L
L
--
N
F
S
Y
R
Y
Y
N
K
-
K
-
Q
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
----
202
HHSearch
62.67
20%
-7
- C5 -
-
5IGI
3
?
A:
[6-298]
--------------
T
A
D
T
S
Q
L
Y
A
L
A
A
R
-
H
G
L
K
-
L
H
G
P
L
T
V
N
E
-
L
G
L
D
Y
R
I
V
I
A
T
V
DD
G
----
R
R
W
V
L
R
I
P
R
R
A
E
V
S
A
K
V
E
P
E
A
R
V
-
L
A
M
L
K
N
R
--
L
--
P
F
A
V
P
D
W
R
V
A
N
A
E
L
V
--
A
Y
P
M
LEDS
T
A
-
V
I
Q
P
G
-----
S
S
T
P
D
W
V
-----
V
P----------
Q
D
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
A
V
P
I
S
A
-
A
V
D
--
A
G
M
---
L
-------
I
R
T
P
T
Q
A
R
---
Q
--
K
V
A
D
D
V
D
R
-
V
R
R
--
E
F
V
---
V
-
N
-
D
K
R
L
H
R
W
Q
R
W
L
-
D
-
D
D-
S
S
W
P
D
-
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
--
N
T---
E
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
----
F
G
E
E
G
L
A
K
L
L
L
T
Y
E
A
---
A
G
G
R
V
W
P
R
L
A
H
--
H
I
A
E
R
L
A
F
G
A
V
--
T
Y
A
L
F
A
L
D
S
G
N
-
E
E
Y
L
A
A
A
K
A
Q
L
A
---------
16
PsiBlast_PDB
62.49
18%
-9
- C4 -
-
4DT8
1
?
A:
[9-265]
--------------------
V
E
K
A
I
E
Q
L
Y
P
D
F
-
T
I
N
T
I
E
-
I
S
G
E
G
N
D
C
I
A
Y
E
I
----
N
----
R
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
-
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
----
A
G
F
T
K
I
K
G
V
PLT
P
L
L
L
N
N
L
P
-----
K
-----------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
-
S
-
G
F
K
--
S
-
N
---
L
-------
V
L
D
F
R
E
K
I
---
N
--
E
D
N
K
K
I
K
K
-
L
L
S
RE
L
K
G
P
Q
----
M
K
K
V
D
D
F
Y
R
D
I
L
-
E
-
N
--
E
I
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
TE
K
----
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
--------------------
S
L
M
----
E
-
D
---
D
E
E
Y
----
G
M
E
F
V
S
K
I
------
L
N
H
Y
K
H
K
-
D
I
P
T
V
L
E
K
Y
R
-------------
18
PsiBlast_PDB
62.26
18%
-18
- C4 -
-
4DTA
1
?
A:
[9-265]
--------------------
V
E
K
A
I
E
Q
L
Y
P
D
F
-
T
I
N
T
I
E
-
I
S
G
E
G
N
D
C
I
A
Y
E
I
----
N
----
R
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
-
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
----
A
------
G
-----
M
T
K
I
K
G
V
-----
P
LT
P
L
L
L
N
N
LP
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
-
S
-
G
F
K
--
S
-
N
---
L
-------
V
L
D
F
R
E
K
I
---
N
--
E
D
N
K
K
I
K
K
-
L
L
S
RE
L
K
G
P
Q
----
M
K
K
V
D
D
F
Y
R
D
I
L
-
E
-
N
--
E
I
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
TE
K
----
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
--------------------
S
L
M
----
E
-
D
---
D
E
E
Y
----
G
M
E
F
V
S
K
I
------
L
N
H
Y
K
H
K
-
D
I
P
T
V
L
E
K
Y
R
-------------
8
PsiBlast_PDB
61.92
18%
-15
- C4 -
-
5C4K
1
?
A:
[29-285]
--------------------
V
E
K
A
I
E
Q
L
Y
P
D
F
-
T
I
N
T
I
Q
-
I
S
G
K
G
N
D
C
I
A
Y
E
I
----
N
----
R
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
-
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
----
A
G
F
T
K
I
K
G
V
PLT
P
L
L
L
N
N
L
P
-----
K
-----------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
-
S
-
G
F
K
--
S
-
N
---
L
-------
V
L
D
F
R
E
K
I
---
N
--
E
D
N
K
K
I
K
K
-
L
L
S
RE
L
K
G
P
Q
----
M
K
K
V
D
D
F
Y
R
D
I
L
-
E
-
N
--
E
I
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
TE
K
----
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
--------------------
S
L
M
----
E
-
D
---
D
E
E
Y
----
G
M
E
F
V
S
K
I
------
L
N
H
Y
K
H
K
-
D
I
P
T
V
L
E
K
Y
R
-------------
5
PsiBlast_PDB
61.57
19%
-6
- C4 -
-
4DTB
1
?
A:
[9-265]
--------------------
V
E
K
A
I
E
Q
L
Y
P
D
F
-
T
I
N
T
I
E
-
I
S
G
E
G
N
D
C
I
A
Y
E
I
----
N
----
R
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
-
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
----
A
G
Y
T
K
I
K
G
V
P
LT
P
L
L
L
N
N
L
P
-----
K
-----------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
-
S
-
G
F
K
--
S
-
N
---
L
-------
V
L
D
F
R
E
K
I
---
N
--
E
D
N
K
K
I
K
K
-
L
L
S
RE
L
K
G
P
Q
----
M
K
K
V
D
D
F
Y
R
D
I
L
-
E
-
N
--
E
I
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
TE
K
----
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
--------------------
S
L
M
----
E
-
D
---
D
E
E
Y
----
G
M
E
F
V
S
K
I
------
L
N
H
Y
K
H
K
-
D
I
P
T
V
L
E
K
Y
R
-------------
7
PsiBlast_PDB
61.44
18%
-12
- C4 -
-
4N57
1
?
A:
[29-285]
--------------------
V
E
K
A
I
E
Q
L
Y
P
D
F
-
T
I
N
T
I
Q
-
I
S
G
K
G
N
D
C
I
A
Y
E
I
----
N
----
R
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
-
L
K
R
I
H
N
K
--
L
--
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
Y
Q
M
S
F
----
A
G
F
T
K
I
K
G
V
P
LT
P
L
L
L
N
N
L
P
-----
K
-----------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
-
S
-
G
F
K
--
S
-
N
---
L
-------
V
L
D
F
R
E
K
I
---
N
--
E
D
N
K
K
I
K
K
-
L
L
S
RE
L
K
G
P
Q
----
M
K
K
V
D
D
F
Y
R
D
I
L
-
E
-
N
--
E
I
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
TE
K
----
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
--------------------
S
L
M
----
E
-
D
---
D
E
E
Y
----
G
M
E
F
V
S
K
I
------
L
N
H
Y
K
H
K
-
D
I
P
T
V
L
E
K
Y
R
-------------