@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : K9H3M2_9PROT: (2019-01-31 )
MASDRQDLSDRIARAIGHGVRRLSPLSGGCVGDVLRAELEDGAAPVVVKVADDAGGGLDIEGWMLRYLADTSRLPVPGVLHAEAGLLVMEEIQAGGGGISASCQEHAADLLADLHSVTWDAFGLERDTLIGGLHQPNPREASWRTFFRDHRLLYMADESHRAGRLPADVRRKVDTLAGRLDDWIEEPDAPALIHGDMWTGNVLCDGGRIAGFIDPAIYYGDAEIELAFSTLFGTFGEPFFRRYQEKRPLRPGFFEARRDLYNLYPLLVHVRLFGGSYVGSVSRTLDRFVG
Atome Classification :
(20 SA)
----....-.....10......--.-------.-----20........--------.30..-......40-------..------.......50.-.-.---.-..-------..----60........70-.-.....---.--------.-------80----.-------.--------------.----------.....90.....-----..---.-----------------100--........--.110......-.-120-.........130.......140.-...--..-----.150.--.-....-..160......----.---..170-.......180-----.----..-....---190........200..-..-.---..210..-..-.-.-.220....--..-------.---230-------.--.----------------------......-240----..--------..--.--..250-------.......----.------.260..-....-..270..----..---.---....280------........290---------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----MAS
D
-
R
Q
D
L
S
D
R
I
A
R
A
I
G
--
H
-------
G
-----
V
-
R
RLSPLSG--------
G
C
V
G
D
-
V
L
R
A
E
L
E--------DG------AA
P
V
V
V
K
V
AD-D-A---G-GG-------L
D
----
I
E
G
W
M
L
R
Y
L
ADT-S-RLPVP---
G
--------
V
-------
L
H----A-------E--------------A----------
G
L
L
V
M
E
E
I
QAGG-----GG---I-----------------
S
----
A
S
C
Q
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H
A
A
--
D
L
L
A
D
L
H
S
V
T
-
W
-
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---AFGLE
R
D
T
LIGGLHQPNPRE
A
S
W
-
R
T
F
--
F
R-----DH-
R
L
--
L
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Y
M
AD-ESH--RAGRL
P
----
A
---
D
V
R
R
K
-
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L
A
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R
L
D
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-----
W
----
I
E-EPDA---
P
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HGDMWTG
N
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C-DG-
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---
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FID-
P
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--------EK--R--PLR---------P
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L
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L
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--
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L
----FG---G---
S
Y
V
G
S
V
-------
S
R
T
L
D
R
FVG-----------------------------
23
HHSearch
87.13
32%
-29
- C7 -
-
3F7W
7
?
A:
[2-286]
---------
V
N
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R
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-----
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V
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D
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A
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A
A
L
------------------------------
2
PsiBlast_PDB
76.53
35%
-45
- C7 -
-
3F7W
7
?
A:
[31-281]
--------------------------------------------------------------
L
Y
R
V
E
L
A
--------
D
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------
T
-
P
L
F
V
K
A
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---
A
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-------
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---
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----------
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---
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-----------------
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----
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-----
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----
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---
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A
R
I
H
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W
N
G
N
V
L
W
Q
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D
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---
A
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-------
L
---
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--------
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--
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----------------------
L
---
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Y
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L
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R
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R
D
A
Y
N
--------
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V
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A
--
P
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A
---------
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G
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A
R
----
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L
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L
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--
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L
----
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G
---
A
---
A
Y
R
T
T
L
-------
V
D
T
-----------------------------------
1
PsiBlast_PDB
76.35
26%
-11
- C7 -
-
3JR1
3
?
A:
[22-307]
----------
K
S
I
S
Q
V
L
A
E
Q
F
G
A
Y
Y
-------
F
-----
I
-
K
H
K
E
K
L
Y
S
--------
G
E
M
N
E
-
I
W
L
--
I
N
--------
D
E
------
V
Q
T
V
F
V
K
I
N
E
-
R
-
S
---
Y
R
S
M
-------
F
R
----
A
E
A
D
Q
L
A
L
L
A
K
T
-
N
-
S
I
N
V
P
L
V
Y
G
--------
I
-------
G
N
----
S
-------
Q
--------------
G
H
---------
S
F
L
L
L
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A
L
N
K
S
K
-----
N
K
---
Q
-----------------
S
----
S
F
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--
I
F
A
--
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K
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A
Q
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H
Q
I
Q
-
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P
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---
K
Y
G
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W
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G
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W
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K
F
--
F
S
-----
E
N
-
R
I
--
G
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W
Q
L
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C
K
--
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K
G
L
I
F
----
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---
N
I
D
L
I
-
V
Q
I
V
A
D
T
L
S
------------
K
-
H
N
P
K
---
P
-
S
I
L
H
G
N
L
W
I
E
N
C
I
Q
-
V
D
-
D
---
K
I
F
-
V
C
N
-
P
A
-
C
-
Y
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W
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D
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S
---
S
L
--------
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P
F
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N
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Y
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----
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N
--------
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--
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--
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L
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----
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---
K
KQ-
S
Y
V
S
L
T
-------
Q
K
L
I
N
Q
I
L
------------------------------
44
Fugue
76.12
26%
6
- C7 -
-
3JR1
3
?
A:
[14-309]
--N
L
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
--
A
-------
Y
-----
Y
-
F
I
K
H
K
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K
L
--------
Y
S
-
G
E
M
N
E
I
W
L
I
N
--------
D
E
------
V
Q
T
V
F
V
K
I
N
E
-
R
-
S
---
Y
-
R
S
M
------
F
R
----
A
E
A
D
Q
L
A
L
L
A
K
T
-
N
-
S
I
N
V
P
---
L
--------
V
-------
Y
G
I
G
N
S
Q
-------
G
--------------
H
----------
S
F
L
L
L
E
A
L
N
K
S
K
-----
N
----------------------
K
----
Q
S
S
F
T
I
F
A
--
E
K
I
A
Q
L
H
Q
I
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G
P
-
D
---
K
Y
G
L
D
F
D
T
W
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G
P
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N
D
W
Q
T
S
W
-
A
K
F
--
F
S
-----
E
N
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R
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--
G
-
W
Q
L
Q
-
I
C
K
--
E
K
G
L
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----
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---
N
I
D
L
I
-
V
Q
I
V
A
D
T
L
S
K
-----
H
--------
N
P
K
---
P
-
S
I
L
H
G
N
L
W
I
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C
I
Q
-
V
D
-
D
----
K
I
F
V
C
N
-
P
A
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C
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Y
-
W
G
D
R
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C
D
I
--
A
F
-------
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---
S
L
--------
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--
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----------------------
P
F
P
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N
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----
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--------
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---------
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G
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Y
L
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----
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Y
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---
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KKQ
S
Y
V
S
L
T
-------
Q
K
L
I
N
Q
I
L
H
K----------------------------
24
HHSearch
75.92
26%
-17
- C7 -
-
3JR1
3
?
A:
[19-306]
------
G
M
-
W
K
S
I
S
Q
V
L
A
E
Q
F
G
--
A
Y
Y
-----
F
-----
I
-
K
H
K
E
K
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S
--------
G
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M
N
E
-
I
W
L
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N
D
E
---------
V
------
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-
T
V
F
V
K
I
N
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S
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Y
---
R
-
S
M
-------
F
R
----
A
E
A
D
Q
L
A
L
L
A
K
T
-
N
-
S
I
N
V
P
---
L
--------
V
-------
Y
G
----
I
-------
G
--------------
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------
S
F
L
L
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A
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K
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K
----------
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-----------------
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S
S
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K
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N
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W
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W
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A
K
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N
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R
I
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G
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Q
L
Q
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K
G
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F
G
N
-
I
D
L
I
V
Q
I
V
A
D
-----
T
----
L
S
K
H
N
P
K
---
P
-
S
I
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N
L
W
I
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I
Q
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V
D
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D
---
K
-
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F
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C
N
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P
A
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C
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Y
-
W
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R
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C
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--
A
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-------
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--------
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P
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----
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I
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Y
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Q
---
S
Y
V
S
L
T
-------
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K
L
I
N
Q
I
-------------------------------
28
HHSearch
56.31
20%
-24
- C7 -
-
5IGH
-
?
A:
[9-298]
---------
T
S
Q
L
Y
A
L
A
A
R
-
H
G
--
L
-------
K
L
----
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--------
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I
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------
R
-
R
W
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I
P
R
R
A
E
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---
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A
K
-------
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----
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V
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A
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L
-
P
F
A
V
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---
D
--------
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-------
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----
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-------
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--------------
A
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-----
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---
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----
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A
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A
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---
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Q
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V
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A
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D
--
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R
V
R
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F
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V
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----------
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K
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-
L
H
R
W
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R
W
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-----
D
----
S
S
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W
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D
F
---
S
-
V
V
V
H
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Y
V
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H
V
L
I
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D
N
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---
R
V
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W
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--
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-------
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---
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--------
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--
F
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--------------------
E
G
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A
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T
----
Y
E
--------
A
A
--
G
--
G
R
V
W
--------
P
R
-
L
A
H
H
I
A
E
R
L
------
A
F
-
G
A
V
-
T
Y
A
L
-
F
A
L
--
D
S
----
G
N
---
E
---
E
Y
L
A
A
A
-------
K
A
Q
L
A
---------------------------------
27
HHSearch
54.11
20%
-21
- C7 -
-
5IGI
3
?
A:
[9-298]
---------
T
S
Q
L
Y
A
L
A
A
R
-
H
G
--
L
-------
K
L
----
H
-
G
P
L
T
V
N
E
L
--------
G
L
D
Y
R
-
I
V
I
A
T
V
D
--------
D
G
------
R
-
R
W
V
L
R
I
P
R
R
A
E
V
---
S
-
A
K
-------
V
E
----
P
E
A
R
V
L
A
M
L
K
N
R
-
L
-
P
F
A
V
P
---
D
--------
W
-------
R
V
----
A
-------
N
--------------
A
E
L
V
A
Y
PMLE-
D
S
T
A
-
V
I
Q
P
G
S
S
-----
T
P
---
D
WVVPQD-----------
S
----
E
V
F
A
E
S
F
A
--
T
A
L
A
A
L
H
A
V
P
-
I
-
S
---
A
A
V
D
A
G
--
M
L
I
--
R
T
P
T
Q
A
R
Q
K
V
-
A
D
D
--
V
D
--------------
R
V
R
R
-------
E
F
V
V
N
----------
D
K
R
-
L
H
R
W
Q
R
W
L
D
D
-----
D
----
S
S
-
W
P
D
F
---
S
-
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
-
D
N
T
E
---
R
V
S
G
M
I
D
-
W
S
E
A
-
R
-
V
D
D
P
A
I
D
M
--
A
A
-------
H
---
L
M
--------
V
--
F
G
E
--------------------
E
G
L
A
K
L
-
L
L
T
----
Y
E
--------
A
A
--
G
--
G
R
V
W
--------
P
R
-
L
A
H
H
I
A
E
R
L
------
A
F
-
G
A
V
-
T
Y
A
L
-
F
A
L
--
D
S
----
G
N
---
E
---
E
Y
L
A
A
A
-------
K
A
Q
L
A
---------------------------------
47
Fugue
52.25
13%
-10
- C7 -
-
3HAM
3
?
A:
[1-299]
----
M
V
N
L
-
D
A
E
I
Y
E
H
L
N
K
Q
I
K
--
I
---------------
N
E
L
R
Y
L
S
S
--------
G
D
D
S
D
-
T
F
L
C
-----------
N
E
------
Q
Y
V
V
K
V
P
K
R
D
-
S
-
V
---
R
-
I
S
-------
Q
K
----
R
E
F
E
L
Y
R
F
L
E
N
C
-
K
L
S
Y
Q
I
P
---
A
--------
V
-------
V
Y
----
Q
-------
S
--------------
D
----------
R
F
N
I
M
K
Y
I
K
G
E
R
I
T
Y
--
E
Q
---
Y
-----------------
H
----
K
L
S
E
K
E
K
D
--
A
L
A
Y
D
E
A
T
F
L
-
K
-
E
---
L
H
S
I
E
I
D
C
S
V
S
L
F
S
D
A
L
V
N
K
K
D
K
-
F
L
Q
--
D
K
-----
K
L
-
L
I
--
S
-
I
L
E
K
-
E
Q
L
--
L
T
D
E
M
L
----
E
---
H
I
E
T
I
-
Y
E
N
I
L
N
N
A
V
L
-----
F
--------
K
Y
T
---
P
-
C
L
V
H
N
D
F
S
A
N
N
M
I
F
-
R
N
-
N
---
R
L
F
G
V
I
D
F
G
D
-
F
-
N
-
V
G
D
P
D
N
D
F
LC
L
L
-------
D
---
C
S
--------
T
--
D
----------------------
D
F
G
K
E
F
-
G
R
K
----
V
L
--------
K
Y
Y
Q
H
--
K
A
P
---------
E
V
A
E
R
K
A
----
E
------
L
N
-
D
V
Y
-
W
S
I
D
-
Q
I
I
--
Y
G
----
Y
E
---
R
---
K
D
R
E
M
L
-------
I
K
G
V
S
E
L
L
Q
TQAEMFIF---------------------
46
Fugue
51.77
15%
-17
- C7 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
----
L
S
A
E
-
D
A
K
K
L
T
E
L
A
E
N
V
L
--
Q
-------
G
-----
W
-
D
V
Q
A
E
K
I
D
--------
V
I
Q
A
L
-
V
W
K
V
H
T
D
--------
S
G
--------
A
V
C
L
K
R
I
H
-
R
-
P
---
E
-
K
K
-------
A
L
----
F
S
I
F
A
Q
D
Y
L
A
K
K
-
G
M
N
V
P
G
I
---
L
P
N
KKGSL
Y
S
-------
K
H
----
G
-------
S
--------------
F
----------
L
F
V
V
Y
D
W
I
E
G
R
P
-----
F
E
---
L
-----------------
T
----
V
K
Q
D
L
E
F
I
M
-
K
G
L
A
D
F
H
T
A
S
-
V
-
G
Y
Q
P
P
N
G
V
P
I
F
T
K
L
G
R
W
P
N
H
Y
T
K
R
C
K
Q
M
E
T
W
--
K
L
M
A
E
A
E
K
E
-
D
P
--
F
-
S
Q
L
Y
-
L
Q
E
--
I
D
G
F
I
E
----
D
---
G
L
R
I
K
-
D
R
L
L
Q
S
T
Y
V
P
-----
W
----
T
E
-
Q
L
K
K
---
S
P
N
L
C
H
Q
D
Y
G
T
G
N
T
L
L
-
G
E
-
N
---
E
Q
I
W
V
I
D
-
L
D
-
T
-
V
-
S
F
D
L
P
I
R
D
--
L
R
-------
K
M
--
I
I
P
L
L
DTTGV
W
--
D
----------------------
D
E
T
F
N
V
M
L
N
A
----
Y
E
--------
S
R
--
A
--
P
L
T
-------------
E
E
Q
----
K
------
Q
V
M
F
I
D
M
L
F
P
Y
-
E
L
Y
--
D
V
----
I
R
---
E
---
K
Y
V
R
K
S
-------
A
L
P
K
E
E
L
E
S
A
F
E
Y
E
R
I
K
A
N
A
L
R
QLI-------------
33
HHSearch
51.75
16%
-24
- C7 -
-
2Q83
4
COTI_BACSU
A:
[22-294]
------------
L
A
E
N
V
L
Q
G
W
D
--
V
-------
Q
-----
A
-
E
K
I
D
V
I
Q
------------
A
L
-
V
W
K
V
H
T
D
--------
S
G
--------
A
V
C
L
K
R
I
H
-
R
-
P
---
E
-
K
K
-------
A
L
----
F
S
I
F
A
Q
D
Y
L
A
K
K
---
G
M
N
V
P
---
G
--------
I
-------
L
P
----
N
-------
K
--------------
K
GSL
Y
S
K
H
GS
F
L
F
V
V
Y
D
W
I
E
G
R
P
-----
F
E
L--
T
-----------------
V
----
K
Q
D
L
E
F
I
M
--
K
G
L
A
D
F
H
T
A
S
-
V
-
G
---
Y
Q
P
P
N
G
---
V
P
I
F
T
K
L
G
R
W
P
N
H
Y
-
T
K
R
--
C
K
-----
Q
---
M
--
E
-
T
W
K
L
-
M
A
E
A
E
K
E
D
P
F
S
Q
L
Y
L
Q
E
I
D
G
F
I
E
D
-
G
L
R
I
K
D
R
L
L
Q
ST
Y
V
P
W
T
---
E
Q
-
L
K
K
S
---
P
-
N
L
C
H
Q
D
Y
G
T
G
N
T
L
L
-
G
E
-
N
---
E
Q
I
W
V
I
D
-
L
D
T
V
-
S
-
F
D
L
P
I
R
D
L
--
R
K
-------
M
---
I
I
--------
P
--
L
L
DTTGVWD
D
-------------
E
T
F
N
V
M
-
L
N
A
----
Y
E
--------
S
R
--
A
--
P
L
T
---------
E
E
---------------------------------------------------------------------------------------------------
26
HHSearch
50.84
18%
10
- C7 -
-
6EF6
2
?
A:
[27-317]
---------
D
V
T
I
A
Q
Q
A
L
T
H
Y
D
--
V
-------
S
-----
D
N
A
S
L
R
L
L
-
N
--------
L
S
E
N
A
-
T
Y
L
V
E
D
G
--------
E
-------
H
-
Q
S
I
L
R
V
H
R
Q
D
-
Y
HQ-
P
-
H
E
-------
I
E
----
S
E
L
D
W
L
A
A
L
R
T
D
-
S
-
D
V
T
V
P
---
T
--------
V
-------
V
P
----
A
-------
R
DGRR
V
V
T
V
D
P
A
DV
P
R
----------
H
V
V
H
F
E
M
V
G
G
A
E
-----
P
D
EES
L
-----------------
T
----
L
D
D
F
Q
T
L
G
--
R
I
T
A
S
L
H
E
H
S
-
Q
-
R
---
W
T
R
P
A
G
---
F
G
R
F
----
S
W
--
D
W
-
E
H
C
--
L
G
-----
D
T
P
R
W
--
G
-
R
W
Q
D
-
A
------
E
G
V
G
----
A
---
S
E
T
A
L
-
L
T
R
A
Q
D
L
L
H
R
-----
K
L
E
E
Y
G
S
-
G
P
D
R
---
Y
-
G
L
I
H
A
D
L
R
L
A
N
L
L
V
-
D
S
-
S
TPQ
R
T
I
T
V
I
D
-
F
D
D
C
-
G
-
F
G
W
Y
F
Y
D
F
--
G
T
-------
A
---
V
S
--------
F
--
I
EHDPR
L
G
---------------
E
W
Q
E
S
W
-
V
A
G
----
Y
R
--------
S
R
--
R
--
E
L
P
---------
A
A
-
D
E
A
M
----
L
------
P
S
-
F
V
F
-
L
R
R
L
-
L
L
L
--
A
W
----------------------------------------------------------------
50
Fugue
50.68
14%
-16
- C7 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
------
T
L
-
P
A
V
I
S
R
W
L
S
S
V
L
P
--
G
-------
G
AA
P
E
V
T
-
V
E
S
G
V
D
S
T
--------
G
M
S
S
E
-
T
I
I
L
T
A
R
--------
W
Q
Q
DG
R
S
I
Q
Q
K
L
V
A
R
V
A
P
-
A
-
A
---
E
-
D
V
PVFPTYR
L
D
----
H
Q
F
E
V
I
R
L
V
G
E
L
-
T
-
D
V
P
V
P
---
R
--------
V
-------
R
W
----
I
ETTGDVL
G
--------------
T
----------
P
F
F
L
M
D
Y
V
E
--------
G
V
---
V
-----------------
P
----
P
D
V
M
P
Y
T
F
GD
N
W
F
A
D
A
P
A
E
R
-
Q
-
R
---
Q
L
Q
D
A
T
V
A
A
L
A
T
L
H
S
I
P
N
A
Q
N
T
F
-
S
F
L
TD
T
T
-----
L
H
-
R
H
--
F
-
N
W
V
R
-
S
W
Y
--
D
F
A
V
E
G
----
I
---
G
R
S
P
L
-
L
E
R
T
F
E
W
L
Q
S
-----
H
----
W
P
-
D
D
A
A
A
RE
P
-
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
-
R
D
-
F
---
Q
P
V
A
V
L
D
-
W
E
-
M
V
A
-
L
G
P
R
E
L
D
V
--
A
W
-------
M
---
I
F
--------
A
--
H
----------------------
R
V
F
Q
E
L
-
A
G
L
----
A
T
LPGLPEVM
R
E
--
D
--
D
V
R
---------
A
T
Y
Q
A
L
T
----
G
V
E
L
G
DL
H
W
-
F
Y
V
-
Y
S
G
V
-
M
W
A
--
C
V
----
F
M
---
R
---
T
G
A
R
R
V
H
F
GEIEK
P
D
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
EEH----------------
39
HHSearch
50.06
15%
-11
* C7 *
-
2PPQ
-
KHSE_AGRFC
A:
[8-277]
-------
T
-
E
D
E
L
R
N
F
L
T
Q
-
Y
D
--
V
G------
S
-----
L
-
T
S
Y
K
G
I
A
E
-----------
N
S
-
N
F
L
L
H
T
T
--------
K
-------
D
-
P
L
I
L
T
L
Y
E
K------
K
-
N
D
-------
L
P
----
F
F
L
G
L
M
Q
H
L
A
A
K
---
G
L
S
C
P
---
L
--------
P
-------
L
P
----
R
-------
K
--------------
D
GEL
L
G
E
L
SG
R
P
A
A
L
I
S
F
L
E
G
M
W
-----
L
R
K--
P
-----------------
E
----
A
K
H
C
R
E
V
G
--
K
A
L
A
A
M
H
L
A
S
-
E
-
G
---
F
-
E
I
K
R
----
P
N
A
L
S
----
V
D
G
W
-
K
V
L
--
W
D
-----
K
---
S
--
E
-
E
R
A
D
---------
E
V
E
----
K
---
G
L
R
E
E
-
I
R
P
E
I
D
Y
L
A
A
-----
H
----
W
P
-
K
D
L
P
---
A
-
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
-
L
G
-
D
---
E
L
S
G
L
I
D
-
F
Y
F
A
-
C
-
N
D
L
L
A
Y
D
V
--
S
I
-------
C
---
L
N
--------
A
--
W
CFEKDGAYN
V
------------
T
K
G
K
A
L
-
L
E
G
----
Y
Q
--------
S
V
--
R
--
P
L
S
---------
E
A
-
E
L
E
A
----
L
------
P
L
-
L
S
R
-
G
S
A
L
-
R
F
F
--------------------------------------------------------------------
25
HHSearch
48.37
21%
-33
- C7 -
-
5UXD
2
?
A:
[6-254]
-------
D
-
L
D
A
L
L
D
L
A
A
R
H
G
L
D-
L
-------
D
-----
G
-
G
T
L
R
T
E
E
I
--------
G
L
D
F
R
-
V
A
F
A
R
A
H
--------
D
G
------
G
-
D
W
V
L
R
L
P
R
R
P
D
V
---
L
-
E
R
-------
A
A
----
V
E
G
R
L
L
A
M
L
A
P
H
-
L
-
D
V
A
V
P
---
D
--------
W
-------
R
I
----
S
-------
T
--------------
S
----------
E
L
I
A
Y
P
L
L
P
G
S
P
-----
G
L
T
--
V
A
ADG
E
V
S
W
HVDMA----
S
----
T
V
Y
A
R
S
L
G
--
S
V
V
A
Q
L
H
A
V
D
-
A
-
E
---
A
A
A
A
T
G
I
---
E
V
-
R
S
P
A
Q
V
R
G
A
W
-
R
Q
D
--
L
A
-----
R
---------
V
G
-------
A
E
F
E
I
A
----
P
---
A
L
R
----
E
R
W
E
A
W
L
A
D
-----
D
----
G
C
-
W
P
G
H
---
S
-
V
L
T
H
G
E
L
Y
P
A
H
T
L
V
-
E
D
-
E
---
R
I
T
A
V
L
D
-
W
T
T
A
-
A
-
V
G
D
P
A
K
D
L
--
M
F
-------
H
---
Q
V
--------
S
--
A
P
S
--------------------
A
I
F
E
V
A
-
L
Q
A
----
Y
A
--------
E
G
--
G
--
G
R
---------------------------------------------------------------------------------------------------------------
29
HHSearch
46.99
15%
24
- C7 -
-
5IWU
2
?
A:
[1-299]
----
M
S
K
D
-
I
K
Q
V
I
E
I
A
K
K
H
N
L
F-
L
-------
K
-----
E
-
E
T
I
Q
F
N
E
S
--------
G
L
D
F
Q
-
A
V
F
A
Q
D
N
--------
N
G
------
I
-
D
W
V
L
R
L
P
R
R
E
D
V
---
M
-
P
R
-------
T
K
----
V
E
K
Q
A
L
D
L
V
N
K
Y
A
I
-
S
F
Q
A
P
---
N
--------
W
-------
I
I
----
Y
-------
T
--------------
E
----------
E
L
I
A
Y
K
K
L
D
G
V
P
-----
A
G
---
T
IDHNIGNYIWEIDINNV
P
----
E
L
F
H
K
S
L
G
--
R
V
L
A
E
L
H
S
I
P
-
S
-
N
---
K
A
A
A
L
D
L
---
V
-
V
H
T
P
E
E
A
R
M
S
M
-
K
Q
R
--
M
D
-----
A
---------
V
R
A
-
K
------
F
G
V
G
----
E
---
N
---
L
-
W
N
R
W
Q
A
W
L
N
D
-----
D
----
D
M
-
W
P
K
K
---
T
-
G
L
I
H
G
D
V
H
A
G
H
T
M
I
-
D
K
-
D
A--
N
V
T
G
L
I
D
-
W
T
E
A
-
K
-
V
T
D
V
S
H
D
F
--
I
F
-------
N
---
Y
R
--------
A
--
F
G
E
--------------------
E
G
L
E
A
L
-
I
L
A
----
Y
K
--------
E
I
--
G
--
G
Y
Y
---------
W
P
K
M
K
E
H
----
I
------
I
E
-
L
N
A
-
A
Y
P
V
-
S
I
A
--
E
F
A
L
V
S
G
I
---
E
---
E
Y
E
Q
M
A
-------
K
E
A
L
E
V
--------------------------------
60
SP3
46.67
17%
-7
- C7 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
---------------------
G
--
S
-------
P
-----
A
-
A
W
V
E
R
L
F
G
Y
D
W
A
Q
QTI
G
C
S
D
A
-
A
V
F
R
L
S
A
--------
Q
G
------
R
P
V
L
F
V
K
T
D
L
S
G
-
A
---
L
-
N
E
-------
L
Q
----
D
E
A
A
R
L
S
W
L
A
-
T
-
T
-
G
V
P
C
A
---
A
--------
V
-------
L
D
V
V
T
E
A
-------
G
--------------
R
----------
D
W
L
L
L
G
E
V
P
G
Q
D
-----
L
L
---
S
-----------------
S
HLA
P
A
E
K
V
S
I
M
A
--
D
A
M
R
R
L
H
T
L
D
-
P
-
A
---
T
C
P
F
D
H
----------------
Q
-
A
K
H
--
R
I
-----
E
R
-
A
R
--
T
-
R
M
E
A
-
G
L
V
--
D
Q
D
D
L
D
----
E
---
E
H
Q
G
L
A
P
A
E
L
F
A
R
L
K
A
-----
R
----
M
P
-
D
G
E
D
---
L
-
V
V
T
H
G
D
A
C
L
P
N
I
M
V
-
E
N
-
G
---
R
F
S
G
F
I
D
-
C
G
-
R
-
L
G
V
A
D
R
Y
Q
D
I
--
A
L
-------
A
---
T
R
--------
D
I
A
E
----------------------
E
L
G
G
E
W
-
A
D
R
----
F
L
--------
V
L
--
Y
--
G
I
A
---------
A
P
D
-
S
Q
R
----
I
------
A
F
-
Y
R
L
-
L
D
E
F
-
F
----------------------------------------------------------------------
36
HHSearch
46.53
14%
-23
- C7 -
-
1NW1
-
CKA2_CAEEL
B:
[54-392]
----------
E
R
A
H
M
L
C
A
R
F
L
G
--
G
AWKTVPL
E
-----
H
-
L
R
I
S
R
I
K
G
--------
G
M
S
N
M
-
L
F
L
C
R
L
S
EVYPPIRN
E
P
------
N
-
K
V
L
L
R
V
Y
F
N
P
E
T
---
E
-
S
H
-------
L
V
----
A
E
S
V
I
F
T
L
L
S
E
R
---
H
L
G
-
P
---
K
--------
L
-------
Y
G
----
I
-------
F
--------------
S
----------
G
G
R
L
E
E
Y
I
P
S
R
P
-----
L
S
---
C
H
E
I
S
-------------
L
----
A
H
M
S
T
K
I
A
--
K
R
V
A
K
V
H
Q
L
E
-
V
-
P
---
I
W
K
E
P
--------
D
Y
L
C
E
A
L
Q
R
W
-
L
K
Q
--
L
T
-----
G
T
--
V
--
D
-
A
E
H
R
F
D
L
P
--
E
E
C
G
V
S
----
S
---
V
N
C
L
D
-
L
A
R
E
L
E
F
L
R
A
-----
H
----
I
S
L
S
K
S
P
---
V
-
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
-
P
K
------
R
L
V
L
I
D
-
F
E
Y
A
-
S
-
Y
N
Y
R
A
F
D
F
--
A
N
-------
H
---
F
I
--------
E
--
W
T
IDYDIDEAPF
Y
K
I
Q
TENFPE
N
D
Q
M
L
E
F
-
F
L
N
----
Y
L
--------
R
E
--
Q
--
G
N
T
RENE
L
Y
K
K
S
E
D
-
L
V
Q
E
----
T
------
L
P
-
F
V
P
-
V
S
H
F
-
F
W
G
--
V
W
----
G
L
----------------------------------------------------------
52
Fugue
46.28
14%
4
- C7 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
SAFT
F
Q
T
L
-
H
P
D
T
I
M
D
A
L
F
E
H
G
--
I
-------
R
-----
V
-
D
S
G
L
T
P
L
N
--------
S
Y
E
N
R
-
V
Y
Q
F
Q
D
E
--------
D
R
------
R
-
R
F
V
V
K
F
Y
R
-
P
-
E
RWT
A
-
D
Q
-------
I
L
----
E
E
H
Q
F
A
L
Q
L
V
N
--
D
-
E
V
P
V
A
---
A
--------
P
V
A
F
NGQT
L
L
----
N
-------
H
--------------
Q
----------
G
F
Y
F
A
V
F
P
S
V
G
G
-----
R
Q
---
F
EAD--------------
N
----
I
D
Q
M
E
A
V
G
--
R
Y
L
G
R
M
H
Q
T
G
-
R
-
K
----------------
Q
L
F
I
H
R
P
T
I
G
-
L
N
E
--
Y
L
-----
I
E
-
P
R
--
K
-
L
F
E
D
-
A
T
L
--
I
P
S
G
L
K
----
A
---
A
F
L
K
A
-
T
D
E
L
I
A
A
V
T
A
-----
H
----
W
R
-
E
D
F
T
---
V
-
L
R
L
H
G
D
C
H
A
G
N
I
L
W
-
R
D
-
G
P
--
M
F
V
D
L
D
D
-
A
R
-
N
-
G
-
P
A
V
Q
D
L
W
M
--
L
L
-------
N
GD
K
A
E
--------
Q
--
R
----------------------
M
Q
L
E
T
I
-
I
E
A
----
Y
E
--------
E
F
--
S
--
E
F
D
---------
T
A
E
I
G
L
I
----
E
------
P
L
-
R
A
M
-
R
L
V
Y
-
Y
L
A
--
W
L
----
M
R
---
R
---
W
A
D
P
A
F
-------
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY
37
HHSearch
45.98
14%
-25
- C7 -
-
1NW1
-
CKA2_CAEEL
A:
[54-392]
----------
E
R
A
H
M
L
C
A
R
F
L
G
--
G
AWKTVPL
E
-----
H
-
L
R
I
S
R
I
K
G
--------
G
M
S
N
M
-
L
F
L
C
R
L
S
EVYPPIRN
E
P
------
N
-
K
V
L
L
R
V
Y
F
N
P
E
T
---
E
-
S
H
-------
L
V
----
A
E
S
V
I
F
T
L
L
S
E
R
---
H
L
G
-
P
---
K
--------
L
-------
Y
G
----
I
-------
F
--------------
S
----------
G
G
R
L
E
E
Y
I
P
S
R
P
-----
L
S
---
C
H
E
I
S
-------------
L
----
A
H
M
S
T
K
I
A
--
K
R
V
A
K
V
H
Q
L
E
-
V
-
P
---
I
W
K
E
P
--------
D
Y
L
C
E
A
L
Q
R
W
-
L
K
Q
--
L
T
-----
G
T
--
V
--
D
-
A
E
H
R
F
D
L
P
--
E
E
C
G
V
S
----
S
---
V
N
C
L
D
-
L
A
R
E
L
E
F
L
R
A
-----
H
----
I
S
L
S
K
S
P
---
V
-
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
-
P
K
------
R
L
V
L
I
D
-
F
E
Y
A
-
S
-
Y
N
Y
R
A
F
D
F
--
A
N
-------
H
---
F
I
--------
E
--
W
T
IDYDIDEAPF
Y
K
I
Q
TENFPE
N
D
Q
M
L
E
F
-
F
L
N
----
Y
L
--------
R
E
--
Q
--
G
N
T
RENE
L
Y
K
K
S
E
D
-
L
V
Q
E
----
T
------
L
P
-
F
V
P
-
V
S
H
F
-
F
W
G
--
V
W
----
G
L
----------------------------------------------------------
54
Fugue
45.88
12%
3
- C7 -
-
3I1A
2
?
A:
[3-330]
---K
Q
P
I
Q
-
A
Q
Q
L
I
E
L
L
K
V
H
Y
G
--
I
-------
D
-----
I
-
H
T
A
Q
F
I
Q
G
--------
G
A
D
T
N
-
A
F
A
Y
Q
A
D
--------
S
E
------
S
K
S
Y
F
I
K
L
K
Y
-
G
-
Y
---
H
-
D
E
-------
I
N
----
L
S
I
I
R
L
L
H
D
S
G
I
-
K
-
E
I
I
F
P
---
I
HTLEAK--
L
-------
F
Q
----
Q
-------
L
--------------
K
----------
H
F
K
I
I
A
Y
P
F
I
H
A
P
N
GFT
Q
N
---
L
-----------------
T
----
G
K
Q
W
K
Q
L
G
--
K
V
L
R
Q
I
H
E
T
S
-
V
-
P
---
I
S
I
Q
Q
Q
L
R
K
E
I
Y
S
P
K
W
R
E
I
V
R
S
F
-
Y
N
Q
--
I
E
-----
F
D
-
N
S
DD
K
-
L
T
A
A
-
F
K
S
--
F
F
N
Q
N
S
----
A
---
A
I
H
R
L
-
V
D
T
S
E
K
L
S
K
K
-----
I
----
Q
P
-
D
L
D
K
---
Y
-
V
L
C
H
S
D
I
H
A
G
N
V
L
V
-
G
N
-
E
---
E
S
I
Y
I
I
D
W
D
E
-
P
-
M
-
L
A
P
K
E
R
D
L
--
M
F
IGGGVGN
V
---
W
N
--------
K
--
P
----------------------
H
E
I
Q
Y
F
-
Y
E
G
----
Y
G
--------
E
I
--
N
VD
K
T
I
---------
L
S
Y
Y
R
H
E
----
R
------
I
V
-
E
D
I
-
A
V
Y
G
-
Q
D
L
L
S
R
N
----
Q
N
---
N
---
Q
S
R
L
E
S
-------
F
K
Y
F
K
E
M
F
D
PNN
V
V
E
I
A
F
A
T
E-----------------