@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : E3J6D5_FRAIE: (2019-01-28 )
MAAFDVLARLGVDPPDLELLRFGENALYAFRERRLVVRVARPSTDPTHVAQTVEFVRRVAARGMPVSEPADLTELVQPVVTSTGVVTLWTLHDVDEGCRVSAAELGGLVRQFHELAAPEADLLDEWEPFGLIRSRLAAAERDGFDRSLTGPLVDLLASLETAVDRLSARLGIGVMHGDMHYGNVLCLPGRRLLLIDFDQVCRGPREWDLVPNLVTVRRFGLAESDYQEFCAAYGFDLRTSPDVETLVRLRELGMVSWLLQQYGTSAVIDDEIRLRVGTIGESVGPPATRWWAH
Atome Classification :
(20 SA)
----------------------.........10-----...--.-.....20..---.---..--...30-----------.---------.--.-.....-40...-----.--....-50.....-...60-.-...-.---------...70.--..-------....---.-80-----..---.......-90.-----.....-----.----------------.-100.......110.....-------.----.120.---------.-----.--.-.---.---.---.---130--..-..--------.-----------..140---------.----.---------..-.--.---.------..150-----.----------...----.--...160..----.------.-.-.-.--------170---.---..---......180......--.---190--.........200....---...--210..---------------.-----------.-----..-.-----------220------------..-.--.-----------.....230..---.------.-----.-------------..240........-250----------.----------......260-----.....----------.---...270...-....280-----.........-290.--------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------M
A
A
F
D
V
L
A
R
L------GVD--P-P
D
L
E
L
L
R
FG---
E
---
N
A
--
L
Y
A
F
R
-----------E---------
R
--
R
-
L
V
V
R
V-ARPST-----
D
--
P
T
H
V
-
A
Q
T
V
E
F
V
-
R
R
V
A
A-R-GMP-V---------SEPA
D
L
--
T
E
-------
L
V
Q
P
---
V
-V------TS---T
G
V
V
T
L
W
-
T
LH-----DVDEG-----C----------------R-
V
S
A
A
E
L
G
G
L
V
R
Q
F
H
E
LAA-------P----
E
A
-
D
L
---------L-----D--E-W---
E
---
P
---
F
---
G
L
I
--
R
S
-
R
L
--------
A
-----------
A
AE-----------R----D---------GF-D--R---S------L
T
G
P
------
L
----------
V
D
L
----
L
--
A
S
L
E
T
A
V
D
----
R
------
L
-
S
-
A
-R--------L-----
G
---
I
G
---
V
MHGDMHYG
N
V
L
CLP--G---
R
----
R
L
L
L
I
D
F
D
Q
VCRGPRE---WDL--V
P
N
L
V
---------------
T
-----------
V
-----
R
R-F-----------G--------------LA-
E
--
S
-----------
D
Y
Q
E
F
C
A
AYG---F------D-----L-------------RTS-P
D
V
E
T
L
V
R
L
-
R
E
L
----------
G
----------
M
V
S
W
L
L
Q
-------QYGTS----------A---VIDD
E
I
R
L
R
-VGTIG-------ESVGPPATR-WWAH--------------------------------
21
Fugue
74.63
18%
-1
- C5 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
------------SAFT
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
------
G
I
R
--
V
D
S
G
L
T
P
L
N
S
Y
---
E
---
N
R
--
V
Y
Q
F
Q
D
ED--------
R
---------
R
--
R
-
F
V
V
K
F
-
Y
R
P
E
R
W----
T
--
A
D
Q
I
-
L
E
E
H
Q
F
A
-
L
Q
L
V
N
-
D
-
E
V
P
-
V
---------
A
A
P
V
A
F
NG
Q
T
-------
L
L
N
H
---
Q
-
G
------
F
Y
---
F
A
V
F
P
S
V
-
G
G
R
-----
Q
F
E
A
D
-----
N
----------------
I
-
D
Q
M
E
A
V
G
R
Y
L
G
R
M
H
Q
T
G
R
-------
K
----
Q
L
F
I
H
---------
R
-----
P
--
T
-
I
---
G
---
L
---
N
---
E
Y
L
--
I
E
-
P
R
--------
K
-----------
L
F
E
-----------
D
----
A
---------
T
L
I
P
--
S
---
G
------
L
K
A
A
------
F
----------
L
K
A
----
T
--
D
E
L
I
A
A
V
T
----
A
H
-----
W
-
R
-
E
-
D
--------
F
-----
T
---
V
L
---
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
--
G
---------
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
---
Q
D
L
WM
L
L
N
G
D
---------------
K
-----------
A
-----
E
Q
-
R
-----------
M
--------------
Q
L
-
E
--
T
-----------
I
I
E
A
Y
E
E
F
S
E
---
F
------
D
-----
T
-------------
A
E
I
-
G
L
I
E
P
L
R
A
M
-
R
L
V
----------
Y
----------
Y
L
A
W
L
M
R
-------
R
W
A
D
P
----------
A
---
F
P
K
N
F
P
W
L
T
-
G
E
D
Y
W
-------
L
R
Q
T
A
T
F
I
E
-
Q
A
K
V
L
Q
EPPLQLTPMY--------------------
38
HHSearch
70.38
19%
5
- C5 -
-
1ZYL
-
SRKA_ECOLI
A:
[15-287]
-----------------------
T
I
M
D
A
L
F
E
H
------
G
I
R
--
V
D
S
G
L
T
P
L
N
S
Y
---
E
---
N
R
--
V
Y
Q
F
Q
-----------
D
---------
E
DR
R
R
F
V
V
K
F
-
Y
R
P
E
R
W----
T
--
A
D
Q
I
-
L
E
E
H
Q
F
A
-
L
Q
L
V
N
-
D
-
E
V
P
-
V
---------
A
A
P
V
A
F
---
N
--------
G
Q
T
---
L
L
N
------
H
Q
---
G
F
Y
F
A
V
F
-
P
S
V
-----
G
G
R
Q
F
EAD--
N
----------------
I
-
D
Q
M
E
A
V
G
R
Y
L
G
R
M
H
Q
T
G
R
-------
K
----
Q
L
-
F
I
H--------
R
-----
P
--
T
-
I
---
G
---
L
---
N
EYL
I
E
P
--
R
K
-
L
F
--------
E
-----------
D
A
-----------------
T
---------
L
I
-
P
--
S
---
G
------
L
K
A
A
------
F
----------
L
K
A
----
T
--
D
E
L
I
A
A
V
T
----
A
------
H
W
R
-
E
-
D
--------
F
-----
T
---
V
L
---
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
-----------
G
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
---
Q
D
L
--
W
M
L
L
N
---------------
G
-----------
D
-----
K
A
----------------------------
E
Q
-
R
--
M
-----------
Q
L
E
T
I
I
E
A
Y
E
---
E
FSEF--
D
-----
T
-------------
A
E
I
-
G
L
I
E
P
L
R
A
M
-
R
L
V
----------
Y
----------
Y
L
A
W
L
M
R
-------
R
W
A
D
-----------------------------------------------------------------------------------
10
PsiBlast_PDB
68.57
23%
21
- C5 -
-
1ZYL
-
SRKA_ECOLI
A:
[38-289]
---------------------------------------------------------
E
---
N
R
--
V
Y
Q
F
Q
-----------
D
EDR------
R
--
R
-
F
V
V
K
F
-
Y
R
P
E
R
W----
T
--
A
D
Q
I
-
L
E
E
H
Q
F
A
-
L
Q
L
V
N
-
D
-
E
V
P
-
V
---------
A
A
P
V
A
F
--
N
G
---------
Q
T
---
L
-
L
------
N
H
---
Q
G
F
Y
F
----------------------------------------
A
V
F
P
S
V
G
G
--
R
Q
F
-----------------
E
A
-
D
N
---------
I
-----
D
--
Q
-
M
---
E
---
A
---
V
---
G
R
Y
--
L
G
-
R
M
--------
H
-----------
Q
T
G
-----------
R
----
K
QLFIHRPTI
G
L
-
N
--
E
---
Y
------
L
I
E
P
------
R
K
L
F
E
D
ATLIP
S
G
L
----
K
--
A
A
F
L
K
A
T
D
----
E
------
L
-
I
-
A
-
A
V
T
A
H
WRED
F
-----
T
---
V
L
---
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
--
G
---
P
------
M
F
V
D
L
D
D
A
R
N
G
P
A
V
QDL
W
M
L
--
L
N
G
D
K
---------------
A
-----------
E
-----
Q
R
-
M
-----------
Q
--------------
L
E
-
T
I
I
E
-----------
A
Y
E
E
F
S
E
------
F
------
D
-----
T
-------------
A
E
I
-
G
L
I
E
P
L
R
A
M
-
R
L
V
----------
Y
----------
Y
L
A
W
L
M
R
-------
R
W
A
D
P
----------
A
-----------------------------------------------------------------------
37
HHSearch
67.68
19%
4
- C5 -
-
6EF6
2
?
A:
[31-324]
------------------------
A
Q
Q
A
L
T
H
Y
------
D
V
S
--
D
N
A
S
L
R
L
L
N
L
S
---
E
---
N
A
--
T
Y
L
V
E
-----------
D
---------
G
E-
H
Q
S
I
L
R
V
-
H
R
Q
D
Y
-----
H
Q-
P
H
E
I
-
E
S
E
L
D
W
L
-
A
A
L
R
T
D
S
-
D
V
T
-
V
---------
P
T
V
V
P
A
---
R
-------
D
G
R
R
---
V
-
V
T
V
D
P
A
D-
V
---
P
R
H
V
V
H
F
-
E
M
V
-----
G
G
A
E
P
DEESL
T
----------------
L
-
D
D
F
Q
T
L
G
R
I
T
A
S
L
H
E
H
S
Q
-------
R
----
W
T
-
R
P
AG
F
G
-----
R
-----
F
--
S
-
W
---
D
---
W
---
E
---
H
C
L
GD
T
P
-
R
W
--------
G
-----------
R
W
Q
D----------
A
----
E
---------
G
V
-
G
--
A
---
S
------
E
T
A
L
------
L
----------
T
R
A
----
Q
--
D
L
L
H
R
K
L
E
----
E
------
Y
-
G
S
G
-
P
--------
D
-----
R
---
Y
G
---
L
I
H
A
D
L
R
L
A
N
L
L
V
D
S
--
S
TPQ
R
----
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
---
Y
D
F
--
G
T
A
V
S
---------------
F
-----------
I
-----
E
H
-
D
-----------
P
--------------
R
L
-
G
--
E
-----------
W
Q
E
S
W
V
A
G
Y
R
---
S
R
R
E
L
--
P
-----
A
-------------
A
D
E
-
A
M
L
P
S
F
V
F
L
-
R
R
L
----------
L
----------
L
L
A
W
M
G
S
-------
H
T
H
S
-----------------------------------------------------------------------------------
50
HHSearch
62.48
19%
-4
- C5 -
-
4PDY
1
?
A:
[25-303]
-------------------------
Q
A
V
V
S
K
Y
------
D
L
A
--
I
-
Q
Q
R
---
H
A
D
---
G
---
N
---
I
E
V
W
T
-----------
D
S--------
K
G-
R
R
Y
A
A
K
R
-
S
S
I
A
---------
P
A
H
C
-
R
I
M
V
Q
C
L
-
R
H
A
Q
E
-
Q
-
G
F
T
K
F
---------
A
R
F
V
T
T
---
S
-------
S
N
A
P
---
Y
-
V
R
-----
H
G
---
D
F
T
Y
Y
V
T
-
E
W
V
-----
S
G
Q
P
A
-----
N
FGL-------------
P
-
E
H
V
A
Q
T
A
Y
T
L
A
Q
F
H
E
A
T
R
-------
S
----
F
R
-
T
D
---------
W
K----------D--
D
---
V
---
F
---
G
L
F
--
Q
A
-
R
W
--------
R
-----------
D
L
R
Q
M
W
L
G
A
D
----
R
KREK
D
---------
A
F
-
D
--
Q
L
L
L
S
------
M
R
D
E
------
L
----------
H
R
D
----
A
--
A
E
S
L
A
L
F
E
----
D
R
D
V
I
A
Y
L
E
A
-
E
-
R
--------
S
-----
S
---
G
G
---
W
C
H
L
D
V
I
P
S
N
C
L
Y
T
P
--
Q
---
H
----
Q
V
V
L
I
D
F
E
L
A
R
P
A
P
R
A
---
L
D
M
--
A
H
L
L
R
---------------
R
-----------
S
-----
L
E
R
G
-----------
N
--------------
W
D
-
G
--
H
-----------
L
A
Y
A
C
F
L
H
F
D
---
A
V
R
N
I
--
P
-----
K
-------------
S
E
Y
-
R
A
V
E
A
I
L
R
F
-
P
Y
---------------------------------------------------------------------------------------------------------------------------
24
Fugue
62.44
16%
18
- C5 -
-
4OCV
2
?
A:
[24-378]
--------------------T
N
E
A
L
F
D
V
A
S
H
F
------
A
L
E
--
G
-
T
V
D
S
I
E
P
Y
G
---
D
GH
I
N
T
--
T
Y
L
V
T
T
D---------
G
---------
P
--
R
-
Y
I
L
Q
R
-
M
N
T
G
I
FP---
D
--
T
V
N
L
-
M
R
N
V
E
L
V
T
S
T
L
K
A
-
Q
-
G
K
E
-
T
L
D
I
V
R
T
TSG
D
T
W
A
E
I
--
D
G
-------
G
A
W
R
---
V
-
Y
------
K
F
---
I
E
H
T
M
S
Y
-
N
L
V
-----
P
N
P
D
V
-----
F
----------------
R
-
E
A
G
R
A
F
G
D
F
Q
N
F
L
S
G
F
D
A
-------
N
----
Q
L
-
T
E
---------
T
-----
I
--
A
-
H
FHD
T
---
P
---
H
---
R
F
E
--
D
F
-
K
K
--------
A
-----------
L
A
A
-----------
D
----
E
---------
L
G
-
R
--
A
---
A
------
G
C
G
P
------
E
----------
I
E
F
----
Y
--
L
S
H
A
D
Q
Y
A
----
V
------
V
-
M
-
D
-
G
--------
L
R
D
GSI
P
---
L
R
---
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
TT
G
---
K
----
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
---
F
D
F
--
G
D
S
I
R
---------------
F
GASTALEDERD
L
-----
D
K
-
V
-----------
H
--------------
F
S
-
T
--
E
-----------
L
F
R
A
Y
T
E
G
F
V
---
G
------
E
-----
L
-------------
R
D
S
-
I
T
A
R
E
A
E
L
L
-
P
F
S
----------
G
N
L
L
T
M
E
C
G
M
R
F
L
A
D
Y
L
E
GDVYFAT
K
Y
P
E
H
----------
N
---
L
V
R
S
R
T
Q
I
K
-
L
V
R
E
M
-------
E
Q
R
A
D
E
T
R
A
-
I
V
A
D
V
M
E
T
T---------------------------
42
HHSearch
62.03
14%
5
- C5 -
-
5IGI
3
?
A:
[11-300]
-----------------------
Q
L
Y
A
L
A
A
R
H
------
G
L
K
--
L
H
G
P
L
T
V
N
E
L
G
L--
D
---
Y
R
--
I
V
I
A
T
-----------
V
---------
D
DG
R
R
W
V
L
R
I
-
P
R
R
A
E
-----
V
--
S
A
K
V
-
E
P
E
A
R
V
L
-
A
M
L
K
N
-
R
L
P
F
A
-
V
---------
P
D
W
R
V
A
---
N
-------
A
E
L
V
---
A
-
Y
------
P
M
---
L
E
D
S
T
A
--
V
I
Q
-----
P
G
S
S
T
-----
P
DWVVPQDS--------
E
-
V
F
A
E
S
F
A
T
A
L
A
A
L
H
A
V
P
I
-------
S
----
A
A
-
V
D
---------
A
GM---
L
--
I
-
R
---
T
---
P
T
Q
A
R
---
Q
K
V
--
A
D
-
D
V
--------
D
-----------
R
V
R
----------------
R
---------
E
F
-
V
----------------
V
------
N
----------
D
K
R
----
L
--
H
R
W
Q
R
W
L
D
----
D
------
D
S
S
-
W
-
P
--------
D
-----
F
---
S
V
---
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T-
E
---
R
----
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
---
I
D
M
--
A
A
H
L
M
---------------
V
-----------
F
------------------------------------
G
-
E
--
E
-----------
G
L
A
K
L
L
L
T
Y
E
---
A
------
A
G
G
R
V
W
P
-------------
R
L
A
-
H
H
I
A
E
R
L
A
F
-
G
A
V
----------
T
----------
Y
A
L
F
A
L
D
-------
S
--
G
N
----------
E
---
E
Y
L
A
A
A
K
A
Q
-
L
A
A
A
------------------------------------------------------
43
HHSearch
60.73
14%
5
- C5 -
-
5IGH
-
?
A:
[11-300]
-----------------------
Q
L
Y
A
L
A
A
R
H
------
G
L
K
--
L
H
G
P
L
T
V
N
E
L
G
L--
D
---
Y
R
--
I
V
I
A
T
-----------
V
---------
D
DG
R
R
W
V
L
R
I
-
P
R
R
A
E
-----
V
--
S
A
K
V
-
E
P
E
A
R
V
L
-
A
M
L
K
N
-
R
L
P
F
A
-
V
---------
P
D
W
R
V
A
---
N
-------
A
E
L
V
---
A
-
Y
------
P
M
---
L
E
D
S
T
A
M
-
V
I
Q
-----
P
G
S
S
T
-----
P
D
W
V
V
P
QDS--------
E
-
V
F
A
E
S
F
A
T
A
L
A
A
L
H
A
V
P
I
-------
S
----
A
A
-
V
D
---------
A
G
M
---
L
--
I
-
R
---
T
---
P
T
Q
A
R
---
Q
K
V
--
A
D
-
D
V
--------
D
-----------
R
V
R
----------------
R
---------
E
F
-
V
----------------
V
------
N
----------
D
K
R
----
L
--
H
R
W
Q
R
W
L
D
----
D
------
D
S
S
-
W
-
P
--------
D
-----
F
---
S
V
---
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
T-
E
---
R
----
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
---
I
D
M
--
A
A
H
L
M
---------------
V
-----------
F
------------------------------------
G
-
E
--
E
-----------
G
L
A
K
L
L
L
T
Y
E
---
A
------
A
G
G
R
V
W
P
-------------
R
L
A
-
H
H
I
A
E
R
L
A
F
-
G
A
V
----------
T
----------
Y
A
L
F
A
L
D
-------
S
--
G
N
----------
E
---
E
Y
L
A
A
A
K
A
Q
-
L
A
A
A
------------------------------------------------------
33
Fugue
60.46
17%
-21
- C5 -
-
3CSV
11
?
A:
[4-333]
--------------------S
R
E
D
E
I
R
D
F
L
A
T
------
H
G
Y
--
A
-
D
W
N
R
T
P
R
Y
------------
Q
R
L
R
S
-----------
P
---------
T
--
G
-
A
K
A
V
L
M
D
W
S
P
E
-----
E
--
G
G
D
T
-
Q
P
F
V
D
L
A
-
Q
Y
L
R
N
-
L
-
D
I
S
-
A
-----------
P
E
I
Y
--
A
E
-------
E
H
A
R
G
L
L
L
-
I
------
E
D
---
L
G
D
A
L
F
T
-
E
V
I
-----
N
N
D
P
A
-----
Q
----------------
E
M
P
L
Y
R
A
A
V
D
L
L
I
H
L
H
D
A
Q
T
-------
P
----
E
L
-
A
R
---------
L
-----
D
----------------
P
---
E
T
L
--
S
E
M
T
R
--------
L
-----------
A
F
S
----------------
E
---------
Y
R
-
Y
--
A
---
I
------
L
G
D
A
------
A
----------
E
D
N
----
R
--
K
R
F
E
H
R
F
A
----
Q
------
I
-
L
-
S
-
A
--------
Q
-----
L
---
E
G
DMV
F
V
H
R
D
F
H
A
Q
N
L
L
W
L
P
--
E
---
R
EGLA
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
---
Y
D
L
--
V
S
L
L
Q
---------------
D
-----------
A
RRDVP
A
Q
-
V
-----------
E
--------------
A
Q
M
I
--
D
-----------
H
Y
I
Q
A
T
G
V
D
E
---
S
------
H
-----
F
-------------
R
S
A
-
Y
A
V
I
A
V
Q
R
N
M
R
I
L
----------
G
----------
I
F
A
R
L
S
Q
-------
R
F
G
K
R
----------
H
---
Y
I
E
-
F
V
P
R
V
-
W
A
H
F
E
-------
R
G
L
A
H
P
A
L
A
-
S
A
A
E
E
I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A-------------
36
HHSearch
60.18
15%
-35
* C5 *
-
2PPQ
-
KHSE_AGRFC
A:
[12-320]
------------------------
L
R
N
F
L
T
Q
Y
------
D
V
G
S-
L
-
T
S
Y
K
G
I
A
E
--------
N
S
--
N
F
L
L
H
-----------
T
---------
T
K
-
D
P
L
I
L
T
L
-
Y
E
K
----------
K
N
D
L
-
P
F
F
L
G
L
M
-
Q
H
L
A
A
-
K
-
G
L
S
-
C
---------
P
L
P
L
P
R
---
K
-------
D
G
E
L
---
L
-
G
E
-----
L
S
---
G
R
P
A
A
L
I
-
S
F
L
-----
E
G
M
W
L
RKP--
E
----------------
A
-
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
A
S
E
-------
G
----
F
E
-
I
K
---------
R
-----
P
--
N
-
A
---
L
---
S
---
V
---
D
G
W
--
K
V
-
L
W
--------
D
-----------
K
S
E
ER---------
A
----
D
---------
E
V
-
E
--
K
-------------
G
------
L
----------
R
E
E
----
I
--
R
P
E
I
D
Y
L
A
----
A
------
H
W
P
-
K
-
D
--------
L
-----
P
---
A
G
---
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
--
D
---
E
----
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
---
Y
D
V
--
S
I
C
L
N
---------------
A
-----------
W
-----
C
F
-
E
KDG--------
A
--------------
Y
N
-
V
--
T
-----------
K
G
K
A
L
L
E
G
Y
Q
---
S
V
R
P
L
--
S
-----
E
-------------
A
E
L
-
E
A
L
P
L
L
S
R
G
-
S
A
L
----------
R
----------
F
F
L
T
R
L
Y
-------
D
W
L
T
T
PAGALVVKKD
P
L
--
E
Y
L
R
K
L
R
F
H
-
R
T
I
A
N
-------
V
A
E
Y
G
L
A
---------------------------------------
41
HHSearch
60.13
16%
7
- C5 -
-
3I1A
4
?
B:
[14-291]
--------------------------
L
L
K
V
H
Y
------
G
I
D
--
I
-
H
T
A
Q
F
I
Q
G
G
A--
D
---
T
N
A
F
A
Y
Q
A
D
-----------
S
---------
E
S-
K
S
Y
F
I
K
L
-
K
Y
G
Y
H
-----------
D
-
E
I
N
L
S
I
I
-
R
L
L
H
D
-
S
-
G
I
K
E
I
---------
I
F
P
I
H
T
---
L
-------
E
A
K
L
---
F
-
Q
Q
-----
L
K
---
H
F
K
I
I
A
Y
-
P
F
I
-----
H
A
P
N
G
FT
Q
N
L
T
----------------
G
-
K
Q
W
K
Q
L
G
K
V
L
R
Q
I
H
E
T
S
V
-------
P
----
I
S
-
I
Q
---------
Q
-----
Q
LR
K
-
E
---
I
---
Y
---
S
---
P
K
W
--
R
E
-
I
V
--------
R
-----------
S
F
Y
NQIE-------
F
DNSD
D
---------
K
L
-
T
--
A
A
F
K
S
------
F
F
N
Q
------
N
----------
S
A
A
----
I
--
H
R
L
V
D
T
S
E
K
L
S
K
K
------
I
-
Q
P
D
-
L
--------
D
-----
K
---
Y
V
---
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---
E
----
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
---
R
D
L
--
M
F
I
G
G
---------------
G
-----------
V
-----
G
N
-
V
-----------
W
--------------
N
K
-
P
--
H
-----------
E
I
Q
Y
F
Y
E
G
Y
G
---
E
------
I
-----
N
-------------
V
D
K
-
T
I
L
S
Y
Y
R
H
E
-
R
I
V
----------
E
----------
D
I
A
V
-------------------------------------------------------------------------------------------------
49
HHSearch
58.47
12%
-10
- C5 -
-
4OCV
2
?
A:
[27-326]
-----------------------
A
L
F
D
V
A
S
H
F
------
A
L
E
GT
V
-
D
S
I
E
P
Y
G
D
G
H--
I
---
N
T
--
T
Y
L
V
T
-----------
T
---------
D
G
-
P
R
Y
I
L
Q
R
-
M
N
T
G
I
-----
F
PD
T
V
N
L
M
R
N
V
E
L
V
T
-
S
T
L
K
A
-
Q
-
G
K
E
-
T
---------
L
D
I
V
R
T
---
T
-------
S
G
D
T
---
W
-
A
E-----
I
D
---
G
G
A
W
R
V
Y
-
K
F
I
-----
E
H
T
M
S
Y
NLVP
N
----------------
P
-
D
V
F
R
E
A
G
R
A
F
G
D
F
Q
N
F
L
S
-------
G
----
F
D
-
A
N
---------
Q
LTETI
A
--
H
-
F
---
H
D--
T
---
P
---
H
R
F
--
E
D
-
F
K
--------
K
-----------
A
L
A
-----------
A
----
D
ELG------
R
A
-
A
GC
G
---
P
------
E
I
E
F
------
Y
----------
L
S
H
----
A
--
D
Q
Y
A
V
V
M
D
----
G
------
L
-
R
D
G
-
S
--------
I
-----
P
---
L
R
---
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
TT
G
---
K
----
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
---
F
D
F
--
G
D
S
I
R
---------------
F
-----------
G
-----
A
S
-
T
ALEDERDLDK
V
H
--------------
F
S
-
T
--
E
-----------
L
F
R
A
Y
T
E
G
F
V
---
G
E
L
R
DSI
T
-----
A
-------------
R
E
A
-
E
L
L
P
F
S
G
N
L
-
L
T
M
----------
E
----------
C
G
M
R
-------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
58.46
25%
-64
- C4 -
-
4PDY
1
?
A:
[59-255]
-------------------------------------------------------------------------------------------------------
R
S
S
I
-----
A
--
P
A
H
C
-
R
I
M
V
Q
C
L
-
R
H
A
Q
E
-
Q
-
G
F
T
-
K
---------
F
A
R
F
V
T
--
T
S
-------
S
N
A
P
---
Y
-
V
------
R
H
GD
F
T
Y
Y
V
T
E
W
V
S
G
Q
-----
P
A
N
F
G
-----
L
----------------
P
-
E
H
V
A
Q
T
A
Y
T
L
A
Q
F
H
E
A
T
R
---------------
S
F
---------
R
-----
T
--
D
-
W
---
K
----DD
V
F
---
G
L
F
--
Q
A
-
R
W
--------
R
D
L
R
Q
M
W
L
G
A
D
R
K
R
E
-----------
K
----
D
---------
A
F
-
D
--
Q
---
L
------
L
L
S
M
------
R
----------
D
E
L
H
R
D
A
A
--
E
S
L
A
L
F
E
D
----
R
D
V
I
A
Y
L
E
-
A
-
E
-
R
--------
S
-----
S
---
G
G
---
W
C
H
L
D
V
I
P
S
N
C
L
Y
T
P
--
Q
---
H
----
Q
V
V
L
I
D
F
E
L
A
R
P
A
P
R
A
---
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
58.33
16%
3
- C5 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
LGGAWK
T
V
P
--
L
-
E
H
L
R
I
S
R
I
K
---
G
G
MS
N
M
--
L
F
L
C
R
L
S
EVYPPIRNE
P
---------
N
--
K
-
V
L
L
R
V
-
Y
F
N
P
E
-----
T
--
E
S
H
L
-
V
A
E
S
V
I
F
-
T
L
L
S
E
-
R
-
H
L
G
-------------
P
K
L
Y
--
G
I
-------
F
S
G
G
---
R
-
L
------
E
E
---
Y
I
P
S
R
P
L
-
S
C
H
-----
E
I
S
L
-----------------------
A
-
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
V
-------
P
IWKE
P
D
-
Y
L
---------
C
-----
E
--
A
-
L
---
Q
---
R
---
W
---
L
K
Q
--
L
T
-
G
T
--------
V
-----------
D
A
E
-----------
H
----
R
---------
F
D
-
L
--
P
---
E
------
E
C
G
V
------
S
----------
S
V
N
----
C
--
L
D
L
A
R
E
L
E
----
F
------
L
-
R
-
A
-
H
--------
I
S
L
SKS
P
---
V
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
-----------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
---
F
D
F
--
A
N
H
F
I
E
W
T
IDYDIDEAPF
Y
K
I
-----------
Q
-----
T
E
-
N
-----------
F
--------------
P
E
-
N
--
D
-----------
Q
M
L
E
F
F
L
N
Y
L
---
R
------
E
-----
Q
-------------
G
N
T
-
R
E
N
E
L
Y
K
K
S
-
E
D
L
----------
V
----------
Q
E
T
L
P
F
V
P
V
S
H
F
--
F
W
G
V
W
----------
G
---
L
L
Q
V
E
L
S
P
V
-
G
F
G
F
A
-------
D
Y
G
R
D
R
L
S
L
-
Y
F
K
H
K
Q
L
L
K
N
LA------------------------
22
Fugue
57.66
13%
-26
- C5 -
-
3I1A
2
?
A:
[3-330]
---------------KQPIQ
A
Q
Q
L
I
E
L
L
K
V
H
Y
------
G
I
D
--
I
-
H
T
A
Q
F
I
Q
G
G
ADT
N
---
A
F
--
A
Y
Q
A
D
S
E---------
S
---------
K
--
S
-
Y
F
I
K
L
-
K
Y
G
Y
------
H
--
D
E
I
N
-
L
S
I
I
R
L
L
-
H
D
S
G
I
-
K
-
E
I
I
-
F
---------
P
I
H
--
T
--
L
E
-------
A
K
L
F
---
Q
-
Q
------
L
K
---
H
F
K
I
I
A
Y
-
P
F
I
H
A
P
N
G
F
T
Q
N
L
-----
T
----------------
G
-
K
Q
W
K
Q
L
G
K
V
L
R
Q
I
H
E
T
S
V
-------
P
----
I
S
-
I
Q
Q
Q
LRKEIYS
P
-----
K
--
W
-
R
---
E
---
I
---
V
---
R
S
F
--
Y
N
-
Q
I
EFDNSDD
K
L
-----------
T
A
A
-----------
F
----
K
---------
S
F
-
F
--
N
---
Q
------
N
S
A
A
------
I
----------
H
R
L
----
V
--
D
T
S
E
K
L
S
K
----
K
------
I
-
Q
-
P
D
L
--------
D
-----
K
---
Y
V
---
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
---
E
----
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
---
R
D
L
--
M
F
I
G
G
---------------
G
-----------
V
-----
G
N
-
V
-----------
W
--------------
N
K
-
P
--
H
-----------
E
I
Q
Y
F
Y
E
G
Y
G
EIN
V
------
D
-----
K
-------------
T
I
L
-
S
Y
Y
R
H
E
R
I
V
-
E
D
I
----------
A
----------
V
Y
G
Q
D
L
L
-------
S
R
N
Q
N
----------
N
---
Q
S
R
L
E
S
F
K
Y
-
F
K
E
M
F
-------
D
P
N
N
V
V
E
I
A
-
F
A
T
E
--------------------------------
32
Fugue
55.51
14%
-26
- C5 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
--T
L
P
A
V
I
S
R
W
L
S
S
V
LPGGAA
P
E
V
T
V
E
S
G
V
D
S
------
T
G
M
--
S
-
S
E
T
I
I
L
T
A
R
---
W
---
Q
Q
--
D
G
R
S
I
-----------
Q
---------
Q
--
K
-
L
V
A
R
V
-
A
P
A
A
E
DVPVF
P
--
T
Y
R
L
-
D
H
Q
F
E
V
I
-
R
L
V
G
E
-
L
T
D
V
P
-
V
---------
P
R
V
R
W
I
--
E
T
TGDVLG
T
P
F
F
L
---
M
-
D
------
Y
V
---
E
G
V
V
P
P
D
-
V
M
P
-----
Y
T
F
G
D
-----
N
----------------
W
-
F
A
D
A
P
A
E
R
Q
R
Q
L
Q
D
A
T
V
A
-------
A
----
L
A
-
T
L
H
S
IPN
A
---
Q
-----
N
--
T
-
F
---
S
---
F
---
L
---
T
D
T
--
T
L
-
H
R
--------
H
-----------
F
N
W
-----------
V
----
R
---------
S
W
-
Y
--
D
---
F
------
A
V
E
G
I
G
R
S
P
L
L
----------
E
R
T
----
F
--
E
W
L
Q
S
H
W
P
----
D
------
D
-
A
-
A
-
A
--------
R
-----
E
---
P
V
---
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
--
F
---
Q
----
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
---
L
D
V
--
A
W
M
I
F
---------------
A
-----------
H
-----
R
V
-
F
-----------
Q
--------------
E
L
-
A
--
G
L
A
TLPGLPEVM
R
E
D
D
V
R
A
T
Y
Q
---
A
------
L
-----
T
-------------
G
V
E
L
G
D
L
H
W
F
Y
V
Y
-
S
G
V
----------
M
----------
W
A
C
V
F
M
R
-------
T
G
A
R
R
----------
V
---
H
F
G
E
I
E
K
P
D
D
V
E
S
L
F
-------
Y
H
A
G
L
M
K
H
L
L
G
E
E
H
--------------------------------
46
HHSearch
54.33
20%
2
- C5 -
-
5UXD
2
?
A:
[9-250]
-----------------------
A
L
L
D
L
A
A
R
H
------
G
L
D
LD
G
-
G
T
L
R
T
E
E
I
G
L--
D
---
F
R
--
V
A
F
A
R
-----------
A
---------
H
DG
G
D
W
V
L
R
L
-
P
R
R
P
D
-----
V
--
L
E
R
A
-
A
V
E
G
R
L
L
-
A
M
L
A
P
H
L
-
D
V
A
-
V
---------
P
D
W
R
I
S
---
T
-----------------------------
S
E
L
I
A
Y
-
P
L
L
-----
P
G
S
P
G
-----
L
T
V
A
ADG
E
V
S
W
HVDMAS
T
-
V
Y
A
R
S
L
G
S
V
V
A
Q
L
H
A
V
D
A
-------
E
----
A
A
-
A
A
T
G-------
I
-----
E
--
V
-
R
---
S
P
A
Q
V
---
R
---
G
A
W
--
R
Q
-
D
L
--------
A
-----------
R
V
G
----------------
A
---------
E
-----
F
---
E
------
I
A
P
A
------
L
----------
R
---------
E
R
W
E
A
W
L
A
----
D
------
D
G
C
-
W
-
P
--------
G
-----
H
---
S
V
---
L
T
H
G
E
L
Y
P
A
H
T
L
V
E
D
--
E
---
R
----
I
T
A
V
L
D
W
T
T
A
A
V
G
D
P
A
---
K
D
L
--
M
F
H
Q
V
---------------
S
-----------
A
------------------------------------
P
-
S
--
A
-----------
I
F
E
V
A
L
Q
A
Y
A
---
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
53.48
17%
15
- C5 -
-
1NW1
-
CKA2_CAEEL
A:
[75-415]
-------------------------------------------
H
-
L
R
I
S
R
I
K
G
G
M--
S
---
N
M
--
L
F
L
C
R
-----------
L
S
EVYPPIRN
E
P-
N
K
V
L
L
R
V
-
Y
F
N
P
E
-----
T
--
E
S
H
L
-
V
A
E
S
V
I
F
-
T
L
L
S
E
-
R
-
H
L
G
-----------
P
K
L
Y
G
I
---
F
-----------------------------
S
G
G
R
L
E
-
E
Y
I
-----
P
S
R
P
L
-----
S
C
H
E
I
S
L----------
A
-
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
V
-------
P
----
I
W
-
K
E
---------
P
-----
D
--
Y
L
C
---
E
---
A
---
L
---
Q
R
W
--
L
K
-
Q
L
--------
T
-----------
G
T
V
-----------
D
----
A
E
H
R
F
-----
D
L
-
P
--
E
---
E
CGVSSV
N
C
L
D
------
L
----------
A
R
E
----
L
--
E
F
L
R
A
H
I
S
----
L
----------
S
-
K
--------
S
-----
P
---
V
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
-----------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
---
F
D
F
--
A
N
H
F
I
---------------
E
-----------
W
-----
T
I
D
Y
-----------
D
IDEAPF
Y
K
I
Q
TENF
P
E
-
N
--
D
-----------
Q
M
L
E
F
F
L
N
Y
L
---
R
------
E
-----
Q
GNTRENE
L
Y
K
K
S
E
D
L
V
-
Q
E
T
L
P
F
V
P
V
-
S
H
F
----------
F
----------
W
G
V
W
G
L
L
-------
Q
V
E
L
S
----------
P
VGF
G
F
A
D
Y
G
R
D
R
-
L
S
L
Y
------------------------------------------------------
31
Fugue
52.22
13%
-3
- C5 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
---------------KTPL
Y
E
T
L
N
E
S
S
A
V
A
L
A
------
V
K
L
--
G
-
L
T
L
T
C
Q
E
I
G
---
D
GNL
N
Y
--
V
F
H
I
Y
-----------
D
---------
R
--
A
-
L
I
I
K
Q
-
A
V
P
Y
W
-----
P
--
L
T
I
D
-
R
A
R
I
E
S
S
-
A
L
I
R
Q
-
G
-
E
H
V
-
P
---------
H
L
V
P
R
V
--
F
Y
-------
S
D
T
E
MA-
V
-
T
------
V
M
---
E
D
L
S
H
L
K
-
I
A
R
-----
K
G
L
I
E
-----
G
----------------
E
-
N
Y
P
H
L
S
Q
H
I
G
E
F
L
G
K
T
L
F
Y
S
SDYAL
E
----
P
K
-
V
K
---------
K
-----
Q
--
L
-
V
---
K
---
Q
---
F
---
T
N
P
--
E
L
-
C
D
--------
I
-----------
T
E
R
LVFTDPFFDHD
T
----
N
---------
D
F
-
E
--
E
---
E
------
L
R
P
F
------
V
----------
E
K
L
----
W
N
N
D
S
V
K
I
E
A
A
----
K
------
L
-
K
-
K
-
S
--------
F
-----
L
TSA
E
T
---
L
I
H
G
D
L
H
T
G
S
I
F
A
S
E
------
H
----
E
T
K
V
I
D
P
E
F
A
F
Y
G
P
I
G
---
F
D
V
--
G
Q
F
I
A
---------------
N
-----------
L
-----
F
L
-
N
-----------
A
--------------
L
S
-
R
--
D
-----------
G
A
D
R
E
P
L
Y
E
H
---
V
------
N
-----
Q
-------------
V
W
E
-
T
F
E
E
T
F
S
E
A
-
W
Q
K
DSLDVYANID
G
----------
Y
L
T
D
T
L
S
-------
H
I
F
E
E
----------
A
---
I
G
F
A
G
C
E
L
I
-
R
R
T
I
G
LAHV
A
D
L
D
T
I
V
P
F
D
K
R
-
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
KRSEFKT
I
T
D
V
I
E
L
F
K
L
L
V
K
52
HHSearch
51.62
17%
16
- C5 -
-
1NW1
-
CKA2_CAEEL
B:
[75-415]
-------------------------------------------
H
-
L
R
I
S
R
I
K
G
G
M--
S
---
N
M
--
L
F
L
C
R
-----------
L
S
EVYPPIRN
E
P-
N
K
V
L
L
R
V
-
Y
F
N
P
E
-----
T
--
E
S
H
L
-
V
A
E
S
V
I
F
-
T
L
L
S
E
-
R
-
H
L
G
-----------
P
K
L
Y
G
I
---
F
-----------------------------
S
G
G
R
L
E
-
E
Y
I
-----
P
S
R
P
L
-----
S
C
H
E
I
S
L----------
A
-
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
V
-------
P
----
I
W
-
K
E
---------
P
-----
D
--
Y
L
C
---
E
---
A
---
L
---
Q
R
W
--
L
K
-
Q
L
--------
T
-----------
G
T
V
-----------
D
----
A
E
H
R
F
-----
D
L
-
P
--
E
---
E
CGVSSV
N
C
L
D
------
L
----------
A
R
E
----
L
--
E
F
L
R
A
H
I
S
----
L
----------
S
-
K
--------
S
-----
P
---
V
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
-----------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
---
F
D
F
--
A
N
H
F
I
---------------
E
-----------
W
-----
T
I
D
Y
-----------
D
IDEAPF
Y
K
I
Q
TENF
P
E
-
N
--
D
-----------
Q
M
L
E
F
F
L
N
Y
L
---
R
------
E
-----
Q
GNTRENE
L
Y
K
K
S
E
D
L
V
-
Q
E
T
L
P
F
V
P
V
-
S
H
F
----------
F
----------
W
G
V
W
G
L
L
-------
Q
V
E
L
S
----------
P
VGF
G
F
A
D
Y
G
R
D
R
-
L
S
L
Y
------------------------------------------------------