@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GBLP_HUMAN: (2018-07-13 )
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.-.......80........90.......------.100.......110.......120.......130.-.-.....140...--.....150.......160.......170.......180.......190.......200.-------------......210.......220.......230..---..--.....240..-.....-250-........260........270.......280...----....290...-..-..300.......310.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTE
Q
M
T
L
R
G
T
LKGHN
G
W
V
T
Q
IATTPQ
F
P
D
M
I
LSASR
D
K
T
I
I
M
W
K
LTRDETNYGI
P
Q
R
A
LRGHSH
F
V
S
D
V
V
IS-SDG
Q
F
A
L
SGSWDG
T
L
R
L
W
D
LTTGTT
T
------
R
R
FVGH
T
K
D
V
L
S
V
A
FSSDN
R
Q
I
VSGSRD
K
T
I
K
L
W
N-T-L
G
V
C
K
Y
T
-VQD--ES
H
S
E
W
V
S
C
V
R
FSPNSSN
P
I
I
V
SCG
W
D
K
L
V
K
V
W
NLAN
C
K
L
KTNHIGHTG
Y
L
N
T
V
T
VSPD-------------G
S
L
CASGGKDG
Q
A
M
L
W
DLNEG
K
H
L
Y
T
L--DG---G
D
--
I
I
N
A
L
CFSPN-
R
Y
W
L
C
-A-A-TGP
S
I
K
I
W
DL-EGK
I
I
V
D
E
L
K
Q
E
V
I
STSSKAEPPQ----C
T
S
L
A
WSADG-
Q
T
-
L
F
AGYTDN
L
V
R
V
W
Q
V
T
IGTR
1
PsiBlast_PDB
93.96
100%
-103
- C1 -
-
4AOW
-
RACK1_HUMAN
A:
[26-337]
--
E
Q
M
T
L
R
G
T
L
K
G
H
N
G
W
V
T
Q
I
A
T
T
P
Q
F
P
D
M
I
L
S
A
S
R
D
K
T
I
I
M
W
K
L
T
R
D
E
T
N
Y
G
I
P
Q
R
A
L
R
G
H
S
H
F
V
S
D
V
V
I
S
-
S
D
G
Q
F
A
L
S
G
S
W
D
G
T
L
R
L
W
D
L
T
T
G
T
T
T
------
R
R
F
V
G
H
T
K
D
V
L
S
V
A
F
S
S
D
N
R
Q
I
V
S
G
S
R
D
K
T
I
K
L
W
N
-
T
-
L
G
V
C
K
Y
T
-
V
Q
D
--
E
S
H
S
E
W
V
S
C
V
R
F
S
P
N
S
S
N
P
I
I
V
S
C
G
W
D
K
L
V
K
V
W
N
L
A
N
C
K
L
K
T
N
H
I
G
H
T
G
Y
L
N
T
V
T
V
S
P
D
-------------
G
S
L
C
A
S
G
G
K
D
G
Q
A
M
L
W
D
L
N
E
G
K
H
L
Y
T
L
--
D
G
---
G
D
--
I
I
N
A
L
C
F
S
P
N
-
R
Y
W
L
C
-
A
-
A
-
T
G
P
S
I
K
I
W
D
L
-
E
G
K
I
I
V
D
E
L
K
Q
E
-------
A
E
P
P
Q
----
C
T
S
L
A
W
S
A
D
G
-
Q
T
-
L
F
A
G
Y
T
D
N
L
V
R
V
W
Q
V
T
I
---
22
HHSearch
84.77
71%
-92
- C1 -
-
4D6V
-
?
A:
[2-313]
-
A
E
H
L
M
F
K
G
N
L
A
G
H
N
G
W
V
T
A
I
A
T
S
S
E
N
P
D
M
I
L
T
A
S
R
D
K
T
V
I
A
W
Q
L
T
R
E
D
N
L
Y
G
F
P
K
K
I
L
H
G
H
N
H
F
V
S
D
V
A
I
S
-
S
D
G
Q
F
A
L
S
S
S
W
D
H
T
L
R
L
W
D
L
N
T
G
L
T
T
------
K
K
F
V
G
H
T
G
D
V
L
S
V
S
F
S
A
D
N
R
Q
I
V
S
A
S
R
D
R
S
I
K
L
W
N
-
T
-
L
G
E
C
K
F
D
-
I
V
E
--
D
G
H
T
E
W
V
S
C
V
R
F
S
P
N
P
A
L
P
V
I
I
S
A
G
W
D
K
T
V
K
V
W
E
L
S
N
C
K
L
K
T
T
H
H
G
H
T
G
Y
L
N
T
L
A
V
S
P
D
-------------
G
S
L
A
A
S
G
G
K
D
G
I
T
M
L
W
D
L
N
E
G
K
H
L
Y
S
L
--
D
A
---
G
D
--
V
I
N
A
L
V
F
S
P
N
-
R
Y
W
L
C
-
A
-
A
-
T
A
S
S
I
K
I
F
D
L
-
E
S
K
S
L
V
D
D
L
Q
P
D
F
D
G
L
S
D
K
A
R
K
P
E
----
C
T
S
L
A
W
S
A
D
G
-
Q
T
-
L
F
A
G
F
S
D
N
L
V
R
V
W
A
V
V
----
2
PsiBlast_PDB
84.50
70%
-92
- C1 -
-
4D6V
-
?
A:
[2-314]
-
A
E
H
L
M
F
K
G
N
L
A
G
H
N
G
W
V
T
A
I
A
T
S
S
E
N
P
D
M
I
L
T
A
S
R
D
K
T
V
I
A
W
Q
L
T
R
E
D
N
L
Y
G
F
P
K
K
I
L
H
G
H
N
H
F
V
S
D
V
A
I
S
-
S
D
G
Q
F
A
L
S
S
S
W
D
H
T
L
R
L
W
D
L
N
T
G
L
T
T
------
K
K
F
V
G
H
T
G
D
V
L
S
V
S
F
S
A
D
N
R
Q
I
V
S
A
S
R
D
R
S
I
K
L
W
N
-
T
-
L
G
E
C
K
F
D
-
I
V
E
--
D
G
H
T
E
W
V
S
C
V
R
F
S
P
N
P
A
L
P
V
I
I
S
A
G
W
D
K
T
V
K
V
W
E
L
S
N
C
K
L
K
T
T
H
H
G
H
T
G
Y
L
N
T
L
A
V
S
P
D
-------------
G
S
L
A
A
S
G
G
K
D
G
I
T
M
L
W
D
L
N
E
G
K
H
L
Y
S
L
--
D
A
---
G
D
--
V
I
N
A
L
V
F
S
P
N
-
R
Y
W
L
C
-
A
-
A
-
T
A
S
S
I
K
I
F
D
L
-
E
S
K
S
L
V
D
D
L
Q
P
D
F
D
G
L
S
D
K
A
R
K
P
E
----
C
T
S
L
A
W
S
A
D
G
-
Q
T
-
L
F
A
G
F
S
D
N
L
V
R
V
W
A
V
V
V
---
25
HHSearch
79.57
54%
-101
- C1 -
-
3FRX
-
GBLP_YEAST
B:
[6-319]
---
V
L
V
L
R
G
T
L
E
G
H
N
G
W
V
T
S
L
A
T
S
A
G
Q
P
N
L
L
L
S
A
S
R
D
K
T
L
I
S
W
K
L
T
G
D
D
Q
K
F
G
V
P
V
R
S
F
K
G
H
S
H
I
V
Q
D
C
T
L
T
-
A
D
G
A
Y
A
L
S
A
S
W
D
K
T
L
R
L
W
D
V
A
T
G
E
T
Y
------
Q
R
F
V
G
H
K
S
D
V
M
S
V
D
I
D
K
K
A
S
M
I
I
S
G
S
R
D
K
T
I
K
V
W
T
-
I
-
K
G
Q
C
L
A
T
---
L
--
L
G
H
N
D
W
V
S
Q
V
R
V
V
P
N
--
S
V
T
I
I
S
A
G
N
D
K
M
V
K
A
W
N
L
N
Q
F
Q
I
E
A
D
F
I
G
H
N
S
N
I
N
T
L
T
A
S
P
D
-------------
G
T
L
I
A
S
A
G
K
D
G
E
I
M
L
W
N
L
A
A
K
K
A
M
Y
T
L
--
S
A
---
Q
D
--
E
V
F
S
L
A
F
S
P
N
-
R
Y
W
L
A
-
A
-
A
-
T
A
T
G
I
K
V
F
S
L
-
D
P
Q
Y
L
V
D
D
L
R
P
E
F
A
-
G
Y
S
K
A
A
E
P
H
----
A
V
S
L
A
W
S
A
D
G
-
Q
T
-
L
F
A
G
Y
T
D
N
V
I
R
V
W
Q
V
M
T
A
N
-
8
PsiBlast_PDB
77.41
53%
-100
- C1 -
-
3FRX
-
GBLP_YEAST
A:
[5-315]
--
E
V
L
V
L
R
G
T
L
E
G
H
N
G
W
V
T
S
L
A
T
S
A
G
Q
P
N
L
L
L
S
A
S
R
D
K
T
L
I
S
W
K
L
T
G
D
D
Q
K
F
G
V
P
V
R
S
F
K
G
H
S
H
I
V
Q
D
C
T
L
T
-
A
D
G
A
Y
A
L
S
A
S
W
D
K
T
L
R
L
W
D
V
A
T
G
E
T
Y
------
Q
R
F
V
G
H
K
S
D
V
M
S
V
D
I
D
K
K
A
S
M
I
I
S
G
S
R
D
K
T
I
K
V
W
T
-
I
-
K
G
Q
C
L
A
T
-
L
L
----
G
H
N
D
W
V
S
Q
V
R
V
V
P
N
--
S
V
T
I
I
S
A
G
N
D
K
M
V
K
A
W
N
L
N
Q
F
Q
I
E
A
D
F
I
G
H
N
S
N
I
N
T
L
T
A
S
P
D
-------------
G
T
L
I
A
S
A
G
K
D
G
E
I
M
L
W
N
L
A
A
K
K
A
M
Y
T
L
--
S
A
---
Q
D
--
E
V
F
S
L
A
F
S
P
N
-
R
Y
W
L
A
-
A
-
A
-
T
A
T
G
I
K
V
F
S
L
-
D
P
Q
Y
L
V
D
D
L
R
P
E
-
F
A
G
Y
S
K
A
A
E
P
H
----
A
V
S
L
A
W
S
A
D
G
-
Q
T
-
L
F
A
G
Y
T
D
N
V
I
R
V
W
Q
V
-----
3
PsiBlast_PDB
77.21
65%
-40
- C1 -
-
3DM0
-
MALE_ECOLI
A:
[372-691]
----
L
V
L
K
G
T
M
R
A
H
T
D
M
V
T
A
I
A
T
P
I
D
N
A
D
I
I
V
S
A
S
R
D
K
S
I
I
L
W
K
L
T
K
D
D
K
A
Y
G
V
A
Q
R
R
L
T
G
H
S
H
F
V
E
D
V
V
L
S
-
S
D
G
Q
F
A
L
S
G
S
W
D
G
E
L
R
L
W
D
L
A
A
G
V
S
T
------
R
R
F
V
G
H
T
K
D
V
L
S
V
A
F
S
L
D
N
R
Q
I
V
S
A
S
R
D
R
T
I
K
L
W
N
-
T
-
L
G
E
C
K
Y
T
-
I
S
E
GG
E
G
H
R
D
W
V
S
C
V
R
F
S
P
N
T
L
Q
P
T
I
V
S
A
S
W
D
K
T
V
K
V
W
N
L
S
N
C
K
L
R
S
T
L
A
G
H
T
G
Y
V
S
T
V
A
V
S
P
D
-------------
G
S
L
C
A
S
G
G
K
D
G
V
V
L
L
W
D
L
A
E
G
K
K
L
Y
S
L
--
E
A
---
N
S
--
V
I
H
A
L
C
F
S
P
N
-
R
Y
W
L
C
-
A
-
A
-
T
E
H
G
I
K
I
W
D
L
-
E
S
K
S
I
V
E
D
L
K
V
D
L
K
----------K
V
I
Y
C
T
S
L
N
W
S
A
D
G
-
S
T
-
L
F
S
G
Y
T
D
G
V
I
R
V
W
G
I
-----
4
PsiBlast_PDB
75.60
53%
-103
- C1 -
-
3RFH
-
GBLP_YEAST
A:
[5-315]
--
E
V
L
V
L
R
G
T
L
E
G
H
N
G
W
V
T
S
L
A
T
S
A
G
Q
P
N
L
L
L
S
A
S
R
D
K
T
L
I
S
W
K
L
T
G
D
D
Q
K
F
G
V
P
V
R
S
F
K
G
H
S
H
I
V
Q
D
C
T
L
T
-
A
D
G
A
Y
A
L
S
A
S
W
D
K
T
L
R
L
W
D
V
A
T
G
E
T
Y
------
Q
R
F
V
G
H
K
S
D
V
M
S
V
D
I
D
K
K
A
S
M
I
I
S
G
S
R
D
K
T
I
K
V
W
T
-
I
-
K
G
Q
C
L
A
T
-
L
L
----
G
H
N
D
W
V
S
Q
V
R
V
V
P
--------------------
L
N
Q
F
Q
I
E
A
D
F
I
G
H
N
S
N
I
N
T
L
T
A
S
P
D
-------------
G
T
L
I
A
S
A
G
K
D
G
E
I
M
L
W
N
L
A
A
K
K
A
M
Y
T
L
--
S
A
---
Q
D
--
E
V
F
S
L
A
F
S
P
N
-
R
Y
W
L
A
-
A
-
A
-
T
A
T
G
I
K
V
F
S
L
-
D
P
Q
Y
L
V
D
D
L
R
P
E
F
A
G
Y
S
A
A
A
E
-
P
H
----
A
V
S
L
A
W
S
A
D
G
-
Q
T
-
L
F
A
G
Y
T
D
N
V
I
R
V
W
Q
V
-----
6
PsiBlast_PDB
74.46
53%
-100
- C1 -
-
3RFG
-
GBLP_YEAST
A:
[6-315]
---
V
L
V
L
R
G
T
L
E
G
H
N
G
W
V
T
S
L
A
T
S
A
G
Q
P
N
L
L
L
S
A
S
R
D
K
T
L
I
S
W
K
L
T
G
D
D
Q
K
F
G
V
P
V
R
S
F
K
G
H
S
H
I
V
Q
D
C
T
L
T
-
A
D
G
A
Y
A
L
S
A
S
W
D
K
T
L
R
L
W
D
V
A
T
G
E
T
Y
------
Q
R
F
V
G
H
K
S
D
V
M
S
V
D
I
D
K
K
A
S
M
I
I
S
G
S
R
D
K
T
I
K
V
W
T
-
I
-
K
G
Q
C
L
A
T
-
L
L
----
G
H
N
D
W
V
S
Q
V
R
V
V
--------------------
N
L
N
Q
F
Q
I
E
A
D
F
I
G
H
N
S
N
I
N
T
L
T
A
S
P
D
-------------
G
T
L
I
A
S
A
G
K
D
G
E
I
M
L
W
N
L
A
A
K
K
A
M
Y
T
L
--
S
A
---
Q
D
--
E
V
F
S
L
A
F
S
P
N
-
R
Y
W
L
A
-
A
-
A
-
T
A
T
G
I
K
V
F
S
L
-
D
P
Q
Y
L
V
D
D
L
R
P
E
-
F
A
G
Y
S
K
A
A
E
P
H
----
A
V
S
L
A
W
S
A
D
G
-
Q
T
-
L
F
A
G
Y
T
D
N
V
I
R
V
W
Q
V
-----
10
PsiBlast_PDB
72.82
30%
-34
- C1 -
-
1VYH
-
LIS1_MOUSE
C:
[104-408]
----------
L
S
G
H
R
S
P
V
T
R
V
I
F
H
P
V
F
S
V
M
V
-
S
A
S
E
D
A
T
I
K
V
W
-----
D
Y
E
T
G
D
F
E
R
T
L
K
G
H
T
D
S
V
Q
D
I
S
F
D
-
H
S
G
K
L
L
A
S
C
S
A
D
M
T
I
K
L
W
D
F
Q
G
F
E
C
I
------
R
T
M
H
G
H
D
H
N
V
S
S
V
S
I
M
P
N
G
D
H
I
V
S
A
S
R
D
K
T
I
K
M
W
E
-
V
Q
T
G
Y
C
V
K
T
-
F
T
----
G
H
R
E
W
V
R
M
V
R
--
P
N
Q
D
G
T
L
I
A
S
C
S
N
D
Q
T
V
R
V
W
V
V
A
T
K
E
C
K
A
E
L
R
E
H
R
H
V
V
E
C
I
S
W
A
P
E
SSYSSISEATGSE
G
P
F
L
L
S
G
S
R
D
K
T
I
K
M
W
D
V
S
T
G
M
C
L
M
T
L
--
V
G
---
H
D
NW
V
R
G
V
L
F
H
S
G
G
-
K
F
I
L
S
-
C
-
A
-
D
D
K
T
L
R
V
W
D
Y
-
K
N
K
R
C
M
K
T
L
---------
N
A
H
E
H
F
----
V
T
S
L
D
F
H
K
T
A
-
P
Y
-
V
V
T
G
S
V
D
Q
T
V
K
V
W
E
------
38
HHSearch
68.98
21%
-44
- C1 -
-
4LG8
-
PRP19_HUMAN
A:
[68-354]
-----------
S
A
S
I
P
G
I
L
A
L
D
L
C
P
S
D
T
N
K
I
L
T
G
G
A
D
K
N
V
V
V
F
D
K
S
S
E
Q
-----
I
L
A
T
L
K
G
H
T
K
K
V
T
S
V
V
F
H
-
P
S
Q
D
L
V
F
S
A
S
P
D
A
T
I
R
I
W
S
V
P
N
A
S
C
V
------
Q
V
V
R
A
H
E
S
A
V
T
G
L
S
L
H
A
T
G
D
Y
L
L
S
S
S
D
D
Q
Y
W
A
F
S
D
-
I
-
Q
T
G
R
V
L
T
K
V
T
D
--
E
T
S
G
C
S
L
T
C
A
Q
F
H
P
D
G
L
--
I
F
G
T
G
T
M
D
S
Q
I
K
I
W
D
L
K
E
R
T
N
V
A
N
F
P
G
H
S
G
P
I
T
S
I
A
F
S
E
N
-------------
G
Y
Y
L
A
T
A
A
D
D
S
S
V
K
L
W
D
L
R
K
L
K
N
F
K
T
L
--
Q
L
D
N-
N
F
--
E
V
K
S
L
I
F
D
Q
S
-
G
T
Y
L
A
-
L
-
G
G
T
D
V
Q
I
Y
I
C
K
Q
-
W
T
E
I
L
H
--
F
---------
T
E
H
S
G
L
----
T
T
G
V
A
F
G
H
H
A
-
K
F
-
I
A
S
T
G
M
D
R
S
L
K
F
Y
S
L
-----
17
PsiBlast_PDB
68.45
32%
-16
- C1 -
-
2G99
-
WDR5_HUMAN
A:
[4-262]
----------------------------------------------
P
V
K
P
N
Y
A
L
-
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
F
E
------
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
-
S
G
K
C
L
K
T
-
L
K
----
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
S
N
--
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
D
-------------
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
K
T
L
I
D
D
D
---
N
P
--
P
V
S
F
V
K
F
S
P
N
G
K
Y
I
L
A
-
A
-
T
-
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
-------
T
Y
T
G
H
K
N
E
K
-
Y
----
C
I
F
A
N
F
S
V
T
G
G
K
W
-
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
-----
32
HHSearch
64.77
23%
-78
- C1 -
-
4YVD
-
PLRG1_HUMAN
A:
[56-352]
------
L
Y
R
V
I
S
G
H
L
G
W
V
R
C
I
A
V
E
P
G
N
-
Q
W
F
V
T
G
S
A
D
R
T
I
K
I
W
D
L
A
S
G
K
L
-----
K
L
S
L
T
G
H
I
S
T
V
R
G
V
I
V
S
-
T
R
S
P
Y
L
F
S
C
G
E
D
K
Q
V
K
C
W
D
L
E
Y
N
K
V
I
------
R
H
Y
H
G
H
L
S
A
V
Y
G
L
D
L
H
P
T
I
D
V
L
V
T
C
S
R
D
S
T
A
R
I
W
D
-
V
-
R
T
K
A
S
V
H
--
T
L
--
S
G
H
T
N
A
V
A
T
V
R
C
Q
A
A
E
P
--
Q
I
I
T
G
S
H
D
T
T
I
R
L
W
D
L
V
A
G
K
T
R
V
T
L
T
N
H
K
K
S
V
R
A
V
V
L
H
P
R
-------------
H
Y
T
F
A
S
G
S
-
P
D
N
I
K
Q
W
K
F
P
D
G
S
F
I
Q
N
L
--
S
G
H--
N
A
--
I
I
N
T
L
T
V
N
S
D
-
G
V
L
V
S
-
G
-
A
-
D
N
G
T
M
H
L
W
D
W
-
R
T
G
Y
N
F
Q
R
V
H
A
----------
E
S
G
----
I
F
A
C
A
F
D
Q
S
E
-
S
R
-
L
L
T
A
E
A
D
K
T
I
K
V
Y
R
E
D
----
14
PsiBlast_PDB
61.35
32%
-17
- C1 -
-
2XL3
2
WDR5_MOUSE
A:
[32-288]
------------------------------------------------
K
P
N
Y
A
L
-
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
F
E
------
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
-
S
G
K
C
L
K
T
-
L
K
----
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
S
N
--
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
D
-------------
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
K
T
L
I
D
D
D
---
N
P
--
P
V
S
F
V
K
F
S
P
N
G
K
Y
I
L
A
-
A
-
T
-
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
-------
T
Y
T
G
H
K
N
E
K
-
Y
----
C
I
F
A
N
F
S
V
T
G
-
G
K
W
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
-----
16
PsiBlast_PDB
61.21
32%
-12
- C1 -
-
3EMH
-
WDR5_HUMAN
A:
[17-272]
-------------------------------------------------
P
N
Y
A
L
-
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
F
E
------
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
-
S
G
K
C
L
K
T
-
L
K
----
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
S
N
--
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
D
-------------
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
K
T
L
I
D
D
D
---
N
P
--
P
V
S
F
V
K
F
S
P
N
G
K
Y
I
L
A
-
A
-
T
-
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
-------
T
Y
T
G
H
K
N
E
K
-
Y
----
C
I
F
A
N
F
S
V
T
G
G
K
W
-
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
-----
46
HHSearch
60.75
23%
-3
- C1 -
-
5MZH
-
DAW1_CHLRE
A:
[87-379]
-------
F
K
V
L
R
A
H
I
L
P
L
T
N
C
A
F
N
K
S
G
-
D
R
F
I
T
G
S
Y
D
R
T
C
K
V
W
N
T
F
T
G
E
-----
E
V
F
T
L
E
G
H
K
N
V
V
Y
A
I
A
F
N
N
P
Y
G
D
K
I
V
T
G
S
F
D
K
T
C
K
L
W
D
A
Y
T
G
Q
L
Y
------
Y
T
L
K
G
H
Q
T
E
I
V
C
L
S
F
N
P
Q
S
T
I
I
A
T
G
S
M
D
N
T
A
K
L
W
D
-
V
-
E
T
G
Q
E
R
--
A
T
L
--
A
G
H
R
A
E
I
V
S
L
G
F
N
T
G
G
D
--
L
I
V
T
G
S
F
D
H
D
S
R
L
W
D
V
R
T
G
Q
C
V
H
V
L
S
G
H
R
G
E
V
S
S
T
Q
F
N
Y
A
-------------
G
T
L
V
V
S
G
S
I
D
C
T
S
R
L
W
D
V
R
S
G
R
C
L
S
V
K
--
Q
G
H--
T
D
--
E
V
L
D
V
A
F
D
A
A
-
G
T
K
M
V
S
A
-
S
-
A
D
G
S
A
R
L
Y
H
T
-
L
T
G
V
C
Q
H
T
L
---------
V
G
H
E
G
E
----
I
S
K
V
A
F
N
P
Q
G
-
T
R
-
L
I
T
A
S
S
D
K
T
C
R
L
W
D
C
D
T
G
--
40
HHSearch
60.73
25%
-16
- C1 -
-
2PBI
4
GNB5_MOUSE
D:
[57-354]
-------
R
R
T
L
K
G
H
G
N
K
V
L
C
M
D
W
C
K
D
K
-
R
R
I
V
S
S
S
Q
D
G
K
V
I
V
W
D
S
F
T
T
N
-----
K
E
H
A
V
T
M
P
C
T
W
V
M
A
C
A
Y
A
-
P
S
G
C
A
I
A
C
G
G
L
D
N
K
C
S
V
Y
P
L
T
F
D
K
N
E
NMAAKK
K
S
V
A
M
H
T
N
Y
L
S
A
C
S
F
T
N
S
D
M
Q
I
L
T
A
S
G
D
G
T
C
A
L
W
D
-
V
-
E
S
G
Q
L
L
Q
--
S
F
--
H
G
H
G
A
D
V
L
C
L
D
L
A
P
S
E
T
G
N
T
F
V
S
G
G
C
D
K
K
A
M
V
W
D
M
R
S
G
Q
C
V
Q
A
F
E
T
H
E
S
D
V
N
S
V
R
Y
Y
P
S
-------------
G
D
A
F
A
S
G
S
D
D
A
T
C
R
L
Y
D
L
R
A
D
R
E
V
A
I
Y
--
S
K
ESI
I
F
--
G
A
S
S
V
D
F
S
L
S
-
G
R
L
L
F
-
A
G
Y
-
N
D
Y
T
I
N
V
W
D
V
-
L
K
G
S
R
V
S
I
L
F
---------
G
H
E
N
R
----
V
S
T
L
R
V
S
P
D
G
-
T
A
-
F
C
S
G
S
W
D
H
T
L
R
V
W
A
------
35
HHSearch
60.55
25%
-19
- C1 -
-
2PBI
3
GNB5_MOUSE
B:
[57-354]
-------
R
R
T
L
K
G
H
G
N
K
V
L
C
M
D
W
C
K
D
K
-
R
R
I
V
S
S
S
Q
D
G
K
V
I
V
W
D
S
F
T
T
N
K
-----
E
H
A
V
T
M
P
C
T
W
V
M
A
C
A
Y
A
-
P
S
G
C
A
I
A
C
G
G
L
D
N
K
C
S
V
Y
P
L
T
F
D
K
N
E
NMAAK
K
K
S
V
A
M
H
T
N
Y
L
S
A
C
S
F
T
N
S
D
M
Q
I
L
T
A
S
G
D
G
T
C
A
L
W
D
-
V
-
E
S
G
Q
L
L
Q
--
S
F
--
H
G
H
G
A
D
V
L
C
L
D
L
A
P
S
E
T
G
N
T
F
V
S
G
G
C
D
K
K
A
M
V
W
D
M
R
S
G
Q
C
V
Q
A
F
E
T
H
E
S
D
V
N
S
V
R
Y
Y
P
S
-------------
G
D
A
F
A
S
G
S
D
D
A
T
C
R
L
Y
D
L
R
A
D
R
E
V
A
I
Y
--
S
K
ESI
I
F
--
G
A
S
S
V
D
F
S
L
S
-
G
R
L
L
F
-
A
G
Y
-
N
D
Y
T
I
N
V
W
D
V
-
L
K
G
S
R
V
S
I
L
F
---------
G
H
E
N
R
----
V
S
T
L
R
V
S
P
D
G
-
T
A
-
F
C
S
G
S
W
D
H
T
L
R
V
W
A
------
12
PsiBlast_PDB
60.50
31%
-18
- C1 -
-
5M25
1
WDR5_HUMAN
A:
[133-388]
-------------------------------------------------
P
N
Y
A
L
-
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
F
E
------
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
-
S
G
K
C
L
K
T
-
L
K
----
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
S
N
--
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
D
-------------
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
K
T
L
I
D
D
D
---
N
P
--
P
V
S
F
V
K
F
S
P
N
G
K
Y
I
L
A
-
A
-
T
-
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
-------
T
Y
T
G
H
K
N
E
K
-
Y
----
C
I
F
A
N
F
S
V
T
G
-
G
K
W
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
-----
18
PsiBlast_PDB
60.42
32%
-11
- C1 -
-
4GM3
-
WDR5_HUMAN
A:
[10-267]
-----------------------------------------------
V
K
P
N
Y
A
L
-
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
F
E
------
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
-
S
G
K
C
L
K
T
-
L
K
----
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
S
N
--
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
D
-------------
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
K
T
L
I
D
D
D
---
N
P
--
P
V
S
F
V
K
F
S
P
N
G
K
Y
I
L
A
-
A
-
T
-
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
-------
T
Y
T
G
H
K
N
E
K
-
Y
----
C
I
F
A
N
F
S
V
T
G
G
K
W
-
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
-----
19
PsiBlast_PDB
60.23
32%
-13
- C1 -
-
4GM8
-
WDR5_HUMAN
A:
[10-267]
-----------------------------------------------
V
K
P
N
Y
A
L
-
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
F
E
------
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
-
S
G
K
C
L
K
T
-
L
K
----
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
S
N
--
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
D
-------------
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
K
T
L
ID-----
N
P
--
P
V
S
F
V
K
F
S
P
N
G
K
Y
I
L
A
-
A
-
T
-
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
-------
T
Y
T
G
H
K
N
E
K
-
Y
----
C
I
F
A
N
F
S
V
T
G
G
K
W
-
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
-----