@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PGAM5_HUMAN: (2018-07-13 )
MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRAGGDAEPRPAEPPAWAGGARPGPGVWDPNWDRREPLSLINVRKRNVESGEEELASKLDHYKAKATRHIFLIRHSQYHVDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPGVCKVSTDLLREGAPIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.....-.-.110-.--------.------.-.....120.......130......--.-----140.......150........160...---.-----...170.....-------..-------180.---..-------------.-------------.--.---------.------------------190------------.------........200.......210.....---.---------------------.220.......230.......240.....----.--------------------------------.------250--..-.......260.....-----------.--------.270.......280.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
F
R
Q
A
L
Q
L
A
A
CGLAG
G
S
A
A
V
L
F
S
A
V
AVGKPRAGGDAEPRPAEPPAWAGGARPGPGVWDPNWDRRE
P
L
S
L
I
N
V
R
KRNVES
G
E
E
E
L
A
S
K
L
D
H
Y
K
AKA
T
R
H
I
F
L
I
RH
S
Q
-
Y
-HVD--G--------S------L-EKDRTLTPLG
R
E
Q
A
E
L
T
G
L
R
L
A
S
L--G-----
L
K
F
N
K
I
V
H
S
S
M
-
T
R
A
I
E
T
T
D
I
I
S
R
HLP---G-----V
C
K
V
S
T
D
L
LRE-------GA-------PIEP---DP-------------P-------------V--S---------H------------------W--------------K------
P
E
A
V
Q
Y
Y
EDGA
R
I
E
A
A
F
R
N
Y
I
H
RADA---R---------------------QEEDS
Y
E
I
F
I
C
H
A
N
V
I
R
Y
I
V
C
R
A
LQFPPE----
G
--------------------------------
W
------
L
----
R
L
-
S
LNNG
S
I
T
H
L
V
IRPN-----------
G
--------
R
V
A
L
R
TLGDTGFMP
P
D
K
ITRS
21
PsiBlast_PDB
95.83
100%
-98
- C2 -
-
5MUF
-
PGAM5_HUMAN
A:
[5-238]
-------------------------------------------------------
G
V
W
D
P
N
W
D
R
R
E
------------------------
H
Y
K
A
K
A
T
R
H
I
F
L
I
R
H
S
Q
-
Y
-
H
V
D
--
G
--------
S
------
L
-
E
K
D
R
T
L
T
P
L
G
R
E
Q
A
E
L
T
G
L
R
L
A
S
L
--
G
-----
L
K
F
N
K
I
V
H
S
S
M
-
T
R
A
I
E
T
T
D
I
I
S
R
H
L
P
---
G
-----
V
C
K
V
S
T
D
L
L
R
E
-------
G
A
-------
P
I
E
P
---
D
P
-------------
P
-------------
V
--
S
---------
H
------------------
W
--------------
K
------
P
E
A
V
Q
Y
Y
E
D
G
A
R
I
E
A
A
F
R
N
Y
I
H
R
A
D
A
---
R
---------------------
Q
E
E
D
S
Y
E
I
F
I
C
H
A
N
V
I
R
Y
I
V
C
R
A
L
Q
F
P
P
E
----
G
--------------------------------
W
------
L
----
R
L
-
S
L
N
N
G
S
I
T
H
L
V
I
R
P
N
-----------
G
--------
R
V
A
L
R
T
L
G
D
T
G
F
M
P
P
D
K
I
T
R
S
23
PsiBlast_PDB
91.11
99%
-118
- C2 -
-
3O0T
8
PGAM5_HUMAN
A:
[2-202]
----------------------------------------------------------------------------------------
M
D
H
Y
K
A
K
A
T
R
H
I
F
L
I
R
H
S
Q
-
Y
-
H
V
D
--
G
--------
S
------
L
-
E
K
D
R
T
L
T
P
L
G
R
E
Q
A
E
L
T
G
L
R
L
A
S
L
--
G
-----
L
K
F
N
K
I
V
H
S
S
M
-
T
R
A
I
E
T
T
D
I
I
S
R
H
L
P
---
G
-----
V
C
K
V
S
T
D
L
L
R
E
-------
G
A
-------
P
I
E
P
---------------------------------------------------------------------------------------
E
A
V
Q
Y
Y
E
D
G
A
R
I
E
A
A
F
R
N
Y
I
H
R
A
D
A
---
R
---------------------
Q
E
E
D
S
Y
E
I
F
I
C
H
A
N
V
I
R
Y
I
V
C
R
A
L
Q
F
P
P
E
----
G
--------------------------------
W
------
L
----
R
L
-
S
L
N
N
G
S
I
T
H
L
V
I
R
P
N
-----------
G
--------
R
V
A
L
R
T
L
G
D
T
G
F
M
P
P
D
K
I
T
R
S
1
HHSearch
90.45
100%
-116
- C2 -
-
3O0T
8
PGAM5_HUMAN
A:
[4-202]
------------------------------------------------------------------------------------------
H
Y
K
A
K
A
T
R
H
I
F
L
I
R
H
S
Q
-
Y
-
H
V
D
--
G
--------
S
------
L
-
E
K
D
R
T
L
T
P
L
G
R
E
Q
A
E
L
T
G
L
R
L
A
S
L
--
G
-----
L
K
F
N
K
I
V
H
S
S
M
-
T
R
A
I
E
T
T
D
I
I
S
R
H
L
P
---
G
-----
V
C
K
V
S
T
D
L
L
R
E
-------
G
A
-------
P
I
E
P
---------------------------------------------------------------------------------------
E
A
V
Q
Y
Y
E
D
G
A
R
I
E
A
A
F
R
N
Y
I
H
R
A
D
A
---
R
---------------------
Q
E
E
D
S
Y
E
I
F
I
C
H
A
N
V
I
R
Y
I
V
C
R
A
L
Q
F
P
P
E
----
G
--------------------------------
W
------
L
----
R
L
-
S
L
N
N
G
S
I
T
H
L
V
I
R
P
N
-----------
G
--------
R
V
A
L
R
T
L
G
D
T
G
F
M
P
P
D
K
I
T
R
S
22
PsiBlast_PDB
90.05
99%
-126
- C2 -
-
3MXO
12
PGAM5_HUMAN
A:
[2-202]
----------------------------------------------------------------------------------------
M
D
H
Y
K
A
K
A
T
R
H
I
F
L
I
R
H
S
Q
-
Y
-
H
V
D
--
G
--------
S
------
L
-
E
K
D
R
T
L
T
P
L
G
R
E
Q
A
E
L
T
G
L
R
L
A
S
L
--
G
-----
L
K
F
N
K
I
V
H
S
S
M
-
T
R
A
I
E
T
T
D
I
I
S
R
H
L
P
---
G
-----
V
C
K
V
S
T
D
L
L
R
E
-------
G
A
-------
P
--------------------------------------------------------------------------------------------
V
Q
Y
Y
E
D
G
A
R
I
E
A
A
F
R
N
Y
I
H
R
A
D
A
---
R
---------------------
Q
E
E
D
S
Y
E
I
F
I
C
H
A
N
V
I
R
Y
I
V
C
R
A
L
Q
F
P
P
E
----
G
--------------------------------
W
------
L
----
R
L
-
S
L
N
N
G
S
I
T
H
L
V
I
R
P
N
-----------
G
--------
R
V
A
L
R
T
L
G
D
T
G
F
M
P
P
D
K
I
T
R
S
2
HHSearch
88.79
100%
-121
- C2 -
-
3MXO
13
PGAM5_HUMAN
B:
[4-202]
------------------------------------------------------------------------------------------
H
Y
K
A
K
A
T
R
H
I
F
L
I
R
H
S
Q
-
Y
-
H
V
D
--
G
--------
S
------
L
-
E
K
D
R
T
L
T
P
L
G
R
E
Q
A
E
L
T
G
L
R
L
A
S
L
--
G
-----
L
K
F
N
K
I
V
H
S
S
M
-
T
R
A
I
E
T
T
D
I
I
S
R
H
L
P
---
G
-----
V
C
K
V
S
T
D
L
L
R
E
-------
G
A
------------------------------------------------------------------------------------------
K
------
P
E
A
V
Q
Y
Y
E
D
G
A
R
I
E
A
A
F
R
N
Y
I
H
R
A
D
A
---
R
---------------------
Q
E
E
D
S
Y
E
I
F
I
C
H
A
N
V
I
R
Y
I
V
C
R
A
L
Q
F
P
P
E
----
G
--------------------------------
W
------
L
----
R
L
-
S
L
N
N
G
S
I
T
H
L
V
I
R
P
N
-----------
G
--------
R
V
A
L
R
T
L
G
D
T
G
F
M
P
P
D
K
I
T
R
S
24
PsiBlast_PDB
62.64
38%
-46
- C2 -
-
3EOZ
1
?
A:
[19-212]
----------------------------------------------------------------------------------------------
N
T
T
K
H
I
I
L
V
R
H
G
---------------------------------
T
K
E
G
C
K
Q
A
D
I
T
G
K
K
L
K
D
I
L
N
N
-----
K
K
V
S
V
I
Y
H
S
D
M
-
I
R
A
K
E
T
A
N
I
I
S
K
Y
F
P
---
D
-----
A
N
L
I
N
D
P
N
L
N
E
-------
G
T
-----------------------------------------------------------------------------------------------------------
K
R
I
N
K
A
Y
E
T
Y
F
Y
K
P
S
G
--------------------------
D
E
D
E
Y
Q
L
V
I
C
H
G
N
V
I
R
Y
F
L
C
R
A
L
Q
I
P
L
F
----
A
--------------------------------
W
------
L
----
R
F
-
S
S
Y
N
C
G
I
T
W
L
V
L
D
D
E
-----------
G
--------
S
V
V
L
R
E
F
G
S
V
S
H
L
P
F
E
S
V
T
--
35
Fugue
61.16
38%
-39
- C2 -
-
3EOZ
1
?
A:
[19-214]
----------------------------------------------------------------------------------------------
N
T
T
K
H
I
I
L
V
R
H
G
T
---------------------------------
K
E
G
C
K
Q
A
D
I
T
G
K
K
L
K
D
I
L
-
N
-----
N
K
K
V
S
V
I
Y
H
S
D
M
I
R
A
K
E
T
A
N
I
I
S
K
Y
F
P
---
D
-----
A
N
L
I
N
D
P
N
L
N
E
------------------------------------------------------------------------------------------------------------------
G
T
K
R
I
N
K
A
Y
E
T
Y
F
Y
K
P
S
--------------------------
G
D
E
D
E
Y
Q
L
V
I
C
H
G
N
V
I
R
Y
F
L
C
R
A
L
Q
I
P
L
F
----
A
--------------------------------
W
------
L
----
R
F
-
S
S
Y
N
C
G
I
T
W
L
V
L
D
D
E
-----------
G
--------
S
V
V
L
R
E
F
G
S
V
S
H
L
P
F
E
S
V
T
Y
F
3
HHSearch
60.88
40%
-30
- C2 -
-
3EOZ
3
?
B:
[21-212]
------------------------------------------------------------------------------------------------
T
K
H
I
I
L
V
R
H
--------------------------------
R
L
T
K
E
G
C
K
Q
A
D
I
T
G
K
K
L
K
D
I
L
N
N
-----
K
K
V
S
V
I
Y
H
S
D
M
-
I
R
A
K
E
T
A
N
I
I
S
K
Y
F
P
---
D
-----
A
N
L
I
N
D
P
N
L
N
E
-------
G
T
-------
P
Y
L
P
---
D
P
-------------
L
-------------
P
--
R
---------
H
------------------
S
--------------
K
------
F
D
A
Q
K
I
K
E
D
N
K
R
I
N
K
A
Y
E
T
Y
F
Y
K
P
S
---------------------------
D
E
D
E
Y
Q
L
V
I
C
H
G
N
V
I
R
Y
F
L
C
R
A
L
Q
I
P
L
F
----
A
--------------------------------
W
------
L
----
R
F
---
Y
N
C
G
I
T
W
L
V
L
D
-------------
G
--------
S
V
V
L
R
E
F
G
S
V
S
H
L
P
F
E
S
V
T
--
12
HHSearch
58.91
21%
2
- C2 -
-
1FZT
-
PMGY_SCHPO
A:
[4-210]
---------------------------------------------------------------------------------------------
E
A
A
P
N
L
L
V
L
T
R
H
G
E
-
S
-
E
W
N
--
K
L
N
L
F
----
T
------
G
-
W
K
D
P
A
L
S
E
T
G
I
K
E
A
K
L
G
G
E
R
L
K
S
R
--
G
-----
Y
K
F
D
I
A
F
T
S
A
L
-
Q
R
A
Q
K
T
C
Q
I
I
L
E
E
V
G
---
E
PN---
L
E
T
I
K
S
E
K
L
N
E
-------
R
Y
YGDLQGL
N
K
D
D
---
A
R
-------------
K
K
WGA
E
Q
-------
V
--
Q
---------
I
------------------
W
R
RSYDIA-------
P
------
P
N
G
E
S
L
K
D
T
A
E
R
V
L
P
Y
Y
K
S
T
I
V
P
H
I
---------------------------
L
K
G
E
K
V
L
I
A
A
H
G
N
S
L
R
A
L
I
M
D
L
E
G
L
T
G
D
----
Q
--------------------------------
I
------
V
----
K
R
-
E
L
A
T
G
V
P
I
V
Y
H
L
D
K
D
-----------
G
--------
K
Y
V
S
K
E
L
I
D
------------
37
Fugue
58.79
16%
-120
* C2 *
-
1UJC
-
SIXA_ECOLI
A:
[1-156]
-------------------------------------------------------------------------------------------------
M
Q
V
F
I
M
R
H
G
D
-
A
-
A
L
D
--
A
--------
A
------
S
-
D
S
V
R
P
L
T
T
N
G
C
D
E
S
R
L
M
A
N
W
L
K
G
Q
--
K
-----
V
E
I
E
R
V
L
V
S
P
F
-
L
R
A
E
Q
T
L
E
E
V
G
D
C
L
N
--------------------------------------------
L
-------------
P
-------------
S
--
S
---------
A
------------------
E
--------------
V
------
L
P
E
L
T
P
C
G
D
V
G
L
V
S
A
Y
L
Q
A
L
T
N
E
------------------------------
G
V
A
S
V
L
V
I
S
H
L
P
L
V
G
Y
L
V
A
E
L
C
P
G
E
T
P
----
P
-----------------------------------------------
M
F
T
T
S
A
I
A
S
V
T
L
D
E
S
-----------
G
--------
N
G
T
F
N
W
Q
M
S
P
C
N
L
K
-------
11
HHSearch
55.93
24%
-20
- C2 -
-
2A6P
1
SUGPH_MYCTU
A:
[9-201]
-----------------------------------------------------------------------------------------------
R
N
H
R
L
L
L
L
R
H
G
E
-
T
-
A
W
S
--
T
L
G
R
H
----
T
------
G
-
G
T
E
V
E
L
T
D
T
G
R
T
Q
A
E
L
A
G
Q
L
L
G
E
L
--
E
-----
L
D
D
P
I
V
I
C
S
P
R
-
R
R
T
L
D
T
A
K
L
A
G
L
T
V
------------
N
E
V
T
G
L
L
A
E
WDYGSYE
G
L
-------
T
T
P
Q
---
I
R
E
SEP---------
D
-------------
W
--
L
---------
V
------------------
W
THG-----------
C
------
P
A
G
E
S
V
A
Q
V
N
D
R
A
D
S
A
V
A
L
A
L
E
H
M
-----------------------------
S
S
R
D
V
L
F
V
S
H
G
H
F
S
R
A
V
I
T
R
W
V
Q
L
P
L
A
----
E
--------------------------------
G
------
S
----
R
F
-
A
M
P
T
A
S
I
G
I
C
G
F
E
H
------------
G
--------
V
R
Q
L
A
V
L
G
L
T
G
H
---------
5
HHSearch
55.69
21%
0
- C2 -
-
4PZA
-
GPGP_MYCTU
B:
[2-218]
-----------------------------------------------------------------------------------------------
R
A
R
R
L
V
M
L
R
H
G
Q
-
T
-
D
Y
N
--
V
GSRM----
Q
------
G
-
Q
L
D
T
E
L
S
E
L
G
R
T
Q
A
V
A
A
A
E
V
L
G
K
---------
R
Q
P
L
L
I
V
S
S
D
L
-
R
R
A
Y
D
T
A
V
K
L
G
E
R
T
G
---------
L
V
V
R
V
D
T
R
L
R
E
-------
T
H
LGDWQGL
T
H
A
Q
---
I
D
A
D
AP---------
G
A
------------
R
--
L
---------
A
------------------
W
R
E
D
ATWA-------
P
------
H
G
G
E
S
R
V
D
V
A
A
R
S
R
P
L
V
A
E
L
V
A
S
E
P
E
WGG
A
---------------------
D
E
P
D
R
P
V
V
L
V
A
H
G
G
L
I
A
A
L
S
A
A
L
L
K
L
P
V
A
----
N
--------------------------------
W
------
P
----
A
L
G
G
M
G
N
A
S
W
T
Q
L
S
G
H
W
A
PGSDFES----
I
--------
R
W
R
L
D
V
W
N
A
S
A
Q
V
--------
20
HHSearch
55.14
21%
10
- C2 -
-
4ODI
-
?
B:
[15-255]
---------------------------------------------------------------------------------------------
A
K
A
K
Y
T
L
V
L
I
R
H
G
E
-
S
-
T
W
N
--
K
E
N
R
F
----
T
------
G
-
W
T
D
V
P
L
S
P
V
G
E
Q
E
A
V
E
A
A
K
A
L
K
E
K
--
G
-----
F
E
F
D
V
A
Y
T
S
V
L
-
Q
R
A
V
V
T
C
W
T
V
L
K
G
T
D
---
M
CH---
I
P
V
K
S
S
W
R
L
N
E
RHYGALQ
G
L
-------
N
K
A
E
---
T
A
-------------
A
K
HG
D
E
Q
-------
V
--
K
---------
I
W
R
RSYDIP
P
P
P
L
E
KSDKR
W
PGNDAVYKMVPNEA
L
------
P
L
T
E
C
L
K
D
T
V
E
R
V
L
P
F
W
F
D
H
I
A
P
S
I
---------------------------
M
E
G
K
R
V
L
V
A
A
H
G
N
S
L
R
G
L
V
K
H
L
D
K
M
S
D
E
----
A
--------------------------------
V
------
L
----
E
L
-
N
I
P
T
G
V
P
L
V
Y
E
L
D
E
D
-----------
L
Q-------
P
V
R
H
Y
Y
L
L
D
E
A
E
L
K
A
K
M
----
19
HHSearch
55.12
21%
12
- C2 -
-
4ODI
-
?
A:
[14-255]
--------------------------------------------------------------------------------------------
M
A
K
A
K
Y
T
L
V
L
I
R
H
G
E
-
S
-
T
W
N
--
K
E
N
R
F
----
T
------
G
-
W
T
D
V
P
L
S
P
V
G
E
Q
E
A
V
E
A
A
K
A
L
K
E
K
--
G
-----
F
E
F
D
V
A
Y
T
S
V
L
-
Q
R
A
V
V
T
C
W
T
V
L
K
G
T
D
---
M
CH---
I
P
V
K
S
S
W
R
L
N
E
RHYGALQ
G
L
-------
N
K
A
E
---
T
A
-------------
A
K
HG
D
E
Q
-------
V
--
K
---------
I
W
R
RSYDIP
P
P
P
L
E
KSDKR
W
PGNDAVYKMVPNEA
L
------
P
L
T
E
C
L
K
D
T
V
E
R
V
L
P
F
W
F
D
H
I
A
P
S
I
---------------------------
M
E
G
K
R
V
L
V
A
A
H
G
N
S
L
R
G
L
V
K
H
L
D
K
M
S
D
E
----
A
--------------------------------
V
------
L
----
E
L
-
N
I
P
T
G
V
P
L
V
Y
E
L
D
E
D
-----------
L
Q-------
P
V
R
H
Y
Y
L
L
D
E
A
E
L
K
A
K
M
----
9
HHSearch
54.77
20%
-67
- C2 -
-
3E9C
-
TIGRB_DANRE
A:
[2-250]
-----------------------------------------------------------------------------------------------
L
T
F
A
L
T
I
V
R
H
G
E
-
T
--------------------------
D
T
P
L
S
D
T
G
H
Q
Q
A
A
A
A
G
R
Y
L
K
D
---------
L
H
F
T
N
V
F
V
S
N
L
-
Q
R
A
I
Q
T
A
E
I
I
L
G
N
N
L
HSS
A
-----
T
E
M
I
L
D
P
L
L
R
E
-------
R
G
F--------------------------------------------------------------------------------------------------
G
E
T
L
E
Q
V
K
T
R
F
K
M
F
L
K
S
L
F
Q
R
M
F
E
---
E
HGSALSSADQPVIAGLADDGA
Q
N
V
P
V
H
A
L
M
V
S
H
G
A
F
I
R
I
S
V
R
H
L
V
E
D
L
Q
C
C
L
P
A
G
--------------------------------
L
------
K
M
N
Q
V
F
S
-
P
C
P
N
T
G
I
S
R
F
I
F
T
I
H
-----------
R
E
ES
V
L
R
A
T
R
I
Q
G
V
F
I
N
R
K
D
H
L
--------
10
HHSearch
54.55
18%
20
- C2 -
-
2YN2
1
YNK8_YEAST
A:
[11-246]
-----------------------------------------------------------------------------------------------
A
I
E
N
I
Y
I
A
R
H
G
Y
R
S
-
N
W
L
PK
G
--------
P
YPPPPT
G
I
D
N
D
V
P
L
S
E
H
G
V
E
Q
A
H
E
L
A
N
Y
I
S
K
L
--
D
-----
V
K
P
E
M
I
F
S
S
P
F
-
Y
R
C
L
E
T
S
K
P
T
V
E
A
L
K
---------
I
P
L
Y
V
D
R
G
V
G
E
-------
W
Y
K
P-----
D
R
P
I
---
I
P
E
P
A
T
H
E
V
M
S
K
F
F
P
S
-------------
M
IS
P
---------
D
------------------
W
EPSIIP--------
S
------
N
K
G
E
T
E
E
D
I
F
E
R
C
H
K
F
W
P
V
F
I
D
R
V
E
R
---
K
---------------------
F
P
N
V
K
T
I
M
I
V
T
H
A
A
T
K
S
A
L
G
M
N
L
L
K
F
S
S
A
----
K
EPIDNK--------------------------
G
------
T
----
F
I
-
R
N
G
S
C
A
I
D
K
F
E
L
---PFEE-------
R
--------
E
W
K
L
T
M
N
G
N
T
S
F
L
T
N
G
-----
6
HHSearch
54.04
21%
25
- C2 -
-
4PZA
-
GPGP_MYCTU
A:
[3-219]
------------------------------------------------------------------------------------------------
A
R
R
L
V
M
L
R
H
G
Q
-
T
-
D
-----RM------
Q
------
G
-
Q
L
D
T
E
L
S
E
L
G
R
T
Q
A
V
A
A
A
E
V
L
G
K
---------
R
Q
P
L
L
I
V
S
S
D
L
-
R
R
A
Y
D
T
A
V
K
L
G
E
R
T
G
---------
L
V
V
R
V
D
T
R
L
R
E
-------
T
H
LGDWQGL
T
H
A
Q
---
I
D
A
D
AP---------
G
A
------------
R
--
L
---------
A
------------------
W
R
E
D
A
TWA-------
P
------
H
G
G
E
S
R
V
D
V
A
A
R
S
R
P
L
V
A
E
L
V
A
S
E
P
E
WGG
A
---------------------
D
E
P
D
R
P
V
V
L
V
A
H
G
G
L
I
A
A
L
S
A
A
L
L
K
L
P
V
A
----
N
--------------------------------
W
------
P
----
A
L
G
G
M
G
N
A
S
W
T
Q
L
S
G
H
W
-FES--------
I
--------
R
W
R
L
D
V
W
N
A
S
A
Q
V
S
-------
4
HHSearch
53.85
18%
15
- C2 -
-
2YN0
-
TFC7_YEAST
A:
[2-250]
------------------------------------------------------------------------------------------------
V
N
T
I
Y
I
A
R
H
G
Y
-
R
S
N
W
L
--
P
EGPYPDPL
T
------
G
I
D
S
D
V
P
L
A
E
H
G
V
Q
Q
A
K
E
L
A
H
Y
L
L
S
L
--
D
-----
N
Q
P
E
A
A
F
A
S
P
F
-
Y
R
C
L
E
T
V
Q
P
I
A
K
L
L
E
---------
I
P
V
Y
L
E
R
G
I
G
E
W
Y
-----
R
P
-------
D
R
K
P
V
I
P
V
P
-------------
A
G
Y
E
I
L
S
K
F
F
PGVI
S
--
Q
---------
E
------------------
W
--------------
D
STLTPN
E
K
G
E
T
E
Q
E
M
Y
M
R
F
K
K
F
W
P
L
F
I
E
R
V
E
K
---
E
---------------------
Y
P
N
V
E
C
I
L
L
V
T
H
A
A
S
K
I
A
L
G
M
S
L
L
G
Y
D
N
P
----
R
--------------------------------
M
SLNENG
D
----
K
I
-
R
S
G
S
C
S
L
D
K
Y
E
I
L
K
K
SYDF
T
Y
I
P
FSD
R
--------
K
W
V
L
T
M
N
G
N
T
E
F
L
S
S
G
E
----
14
HHSearch
52.63
21%
-10
- C2 -
-
3F3K
3
SHB17_YEAST
B:
[2-263]
---------------------------------------------------------------------------------------------
P
S
L
T
P
R
C
I
I
V
R
H
G
Q
-
T
-
E
W
S
--
K
S
GQY----
T
------
G
-
L
T
D
L
P
L
T
P
Y
G
E
G
Q
M
L
R
T
G
E
S
V
F
R
N
--
N
QFLNP
D
N
I
T
Y
I
F
T
S
P
R
-
L
R
A
R
Q
T
V
D
L
V
L
K
P
L
S
---
D
E
Q
R
A
K
I
R
V
V
V
D
D
D
L
R
E
-------
W
E
YGDYEGM
L
T
R
E
---
I
I
-------------
E
L
R
K
S
R
GLDKERP-
W
--
N
---------
I
------------------
W
RDG-----------
C
------
E
N
G
E
T
T
Q
Q
I
G
L
R
L
S
R
A
I
A
R
I
Q
N
L
H
R
K
---
H
Q
S
-------------------
E
G
R
A
S
D
I
M
V
F
A
H
G
H
A
L
R
Y
F
A
A
I
W
F
G
L
G
V
Q
----
K
K
CETIEEIQNVKSYDDDT
V
P
Y
V
K
L
E
S
Y
R
H
L
VD
N
------
P
----
C
F
-
L
L
D
A
G
G
I
G
V
L
S
Y
A
H
H
-----------
N
ID------
E
P
A
L
E
L
A
G
P
F
V
S
P
P
E
------
17
HHSearch
52.45
19%
1
- C2 -
-
3R7A
1
?
B:
[8-232]
-------------------------------------------------------------------------------------------
E
T
D
S
N
V
V
T
L
Y
V
T
R
H
G
K
-
T
-
I
L
N
--
T
N
HRA----
Q
------
G
-
W
A
D
S
P
L
V
E
K
G
V
E
V
A
T
N
L
G
T
G
L
K
D
---------
I
H
F
M
N
A
Y
S
S
D
S
-
G
R
A
I
E
T
A
N
L
V
L
K
Y
S
E
---
Q
SK---
L
K
L
E
Q
R
K
K
L
R
E
LNFGIFE
G
E
-------
K
L
D
N
---
M
W
-------------
D
A
V
G
K
A
A
GVTSPEE
L
--
L
KFS
I
Q
E
V
I
D
L
------------------
I
R
A
A
DP---------
T
------
K
Q
A
E
D
W
E
L
F
S
T
R
I
K
A
E
I
D
K
I
S
E
E
A
A
--------------------------
K
D
G
G
G
N
V
L
V
V
V
H
G
L
L
I
T
T
L
I
E
M
L
D
S
S
K
----------------------------------------------
T
----
K
L
-
G
V
E
N
A
S
V
T
K
I
V
Y
Q
D
------------
G
--------
I
Y
T
V
E
S
V
G
D
M
S
Y
V
A
K
G
K
----