@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQF3: (2017-11-26 )
MLNVLKHFKEKQMPSFQSADAQINYQTFGEPSSPALVFSNSLGTNYGMWQKQFNELKDQFFVICYDNRGHGSSSTPDGPYTVEQLGEDVVRLLDHLNISKAAFCGISMGGLTGQWLAIHYPNRFSHVVVANTAAKIGQEQAWLDRAKLVREQGLQPIATTAASRWFTDPFIQSHPSIVNNLCNDLSAGSAMGYANCCEALAKADVREQLKDIKIPVLVIAGPQDPVTTVADGEFMQQRIPQSKLAEIDASHISNVEQPEVFNKILKDFLVN
Atome Classification :
(20 SA)
.........10........20........30-.--........40........50..-....-..-60........70..-....---..80........90........-100.......110.......120.......-----------130....-----------------...140---.---....-----.-.----..-150.----....-.---..----.160--.......-----.--.170--.-......180--......-..--.-190.---.---.--..----.------.------..200--.--..--------..------...210.......220.......230.......240-.....-.-.250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
L
N
V
L
K
H
F
K
E
KQMPSFQSAD
A
Q
I
N
Y
Q
TFGE--P--SS
P
A
L
V
F
SNSLGTNY
G
M
W
Q
K
Q
F
-
N
E
L
K
-D
Q
-
F
F
V
I
C
YDNRGHGSS-STPD---GP
Y
T
V
E
Q
L
G
E
D
V
V
R
L
L
D
HLNIS-
K
A
A
F
CGISMGGL
T
G
Q
W
L
A
I
HYPNRF
S
H
V
V
V
-----------A
N
T
A
A
KI-----------------G
Q
E
Q
-----
A
---
W
L
D
R
-----
A
-
K
----
L
V
-
R
--
E
----QGLQ-
P
---
I
A
----
T
T
----
A
A
SRWFT-----
D
--
P
F
I
Q
--S-
H
P
S
I
V
N
N
----
L
C
N
D
LS-AG--S-A--M---
G
---
Y
--
A
N
----
C
------
C
------
E
A
L
A
---
K
--
A
D
--------
V
R
------
E
Q
L
K
DIKI
P
V
L
V
I
AGPQDP
V
T
TVA
D
G
E
F
M
Q
Q
RI
P
Q
S
-
K
L
A
E
I
-
D
-
A
S
H
ISNVE
Q
P
E
V
F
N
K
I
L
K
D
FLVN
102
HHSearch
85.57
42%
18
- C1 -
-
2XUA
1
?
H:
[4-264]
------------
M
P
Y
A
A
V
N
G
T
E
L
H
Y
R
I
D
G
E
RH
G
--
N
A
P
W
I
V
L
S
N
S
L
G
T
D
L
S
M
W
A
P
Q
V
-
A
A
L
S
-
K
H
-
F
R
V
L
R
Y
D
T
R
G
H
G
H
S
-
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A
P
K
---
G
P
Y
T
I
E
Q
L
T
G
D
V
L
G
L
M
D
T
L
K
I
A
-
R
A
N
F
C
G
L
S
M
G
G
L
T
G
V
A
L
A
A
R
H
A
D
R
I
E
R
V
A
L
-----------
C
N
T
A
A
R
I
-----------------
G
S
P
E
-----
V
---
W
V
P
R
-----
A
-
V
----
K
A
-
R
--
T
----
E
G
M
H
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A
---
L
A
----
D
A
----
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L
P
R
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F
T
-----
A
--
D
Y
M
E
--
R
-
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P
V
V
L
A
M
----
I
R
D
V
F
V
-
H
T
--
D
-
K
--
E
---
G
---
Y
--
A
S
----
N
------
C
------
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A
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D
---
A
--
A
D
--------
L
R
------
P
E
A
P
G
I
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V
P
A
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D
L
A
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A
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L
A
Q
A
I
A
G
A
-
R
Y
V
E
L
-
D
-
A
S
H
I
S
N
I
E
R
A
D
A
F
T
K
T
V
V
D
F
L
T
E
1
PsiBlast_PDB
83.67
41%
17
* C1 *
-
2XUA
-
?
A:
[13-263]
---------------------
E
L
H
Y
R
I
D
G
E
--
R
H
G
N
A
P
W
I
V
L
S
N
S
L
G
T
D
L
S
M
W
A
P
Q
V
-
A
A
L
S
-
K
H
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F
R
V
L
R
Y
D
T
R
G
H
G
H
S
-
E
A
P
K
---
G
P
Y
T
I
E
Q
L
T
G
D
V
L
G
L
M
D
T
L
K
I
A
-
R
A
N
F
C
G
L
S
M
G
G
L
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G
V
A
L
A
A
R
H
A
D
R
I
E
R
V
A
L
-----------
C
N
T
A
A
R
I
-----------------
G
S
P
E
-----
V
---
W
V
P
R
-----
A
-
V
----
K
A
-
R
--
T
----
E
G
M
H
-
A
---
L
A
----
D
A
----
V
L
P
R
W
F
T
-----
A
--
D
Y
M
E
--
R
-
E
P
V
V
L
A
M
----
I
R
D
V
F
V
-
H
T
--
D
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K
--
E
---
G
---
Y
--
A
S
----
N
------
C
------
E
A
I
D
---
A
--
A
D
--------
L
R
------
P
E
A
P
G
I
K
V
P
A
L
V
I
S
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T
H
D
L
A
A
T
P
A
Q
G
R
E
L
A
Q
A
I
A
G
A
-
R
Y
V
E
L
-
D
-
A
S
H
I
S
N
I
E
R
A
D
A
F
T
K
T
V
V
D
F
L
T
-
103
HHSearch
83.55
39%
-62
- C1 -
-
3OM8
2
?
B:
[9-266]
--------------
L
A
T
S
D
G
A
S
L
A
Y
R
L
D
G
A
--
A
--
E
K
P
L
L
A
L
S
N
S
I
G
T
T
L
H
M
W
D
A
Q
L
-
P
A
L
T
-
R
H
-
F
R
V
L
R
Y
D
A
R
G
H
G
A
S
-
S
V
P
P
---
G
P
Y
T
L
A
R
L
G
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D
V
L
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L
L
D
A
L
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V
R
-
R
A
H
F
L
G
L
S
L
G
G
I
V
G
Q
W
L
A
L
H
A
P
Q
R
I
E
R
L
V
L
-----------
A
N
T
S
A
W
L
-----------------
G
P
A
A
-----
Q
---
W
D
E
R
-----
I
-
A
----
A
V
L
Q
--
A
----
E
D
M
S
-
E
---
T
A
----
A
G
----
F
L
G
N
W
F
P
-----
P
--
A
L
L
E
--
R
-
A
E
P
V
V
E
R
----
F
R
A
M
L
M
-
A
T
--
N
-
R
--
H
---
G
---
L
--
A
G
----
S
------
F
------
A
A
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R
---
D
--
T
D
--------
L
R
------
A
Q
L
A
R
I
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R
P
T
L
V
I
A
G
A
Y
D
T
V
T
A
A
S
H
G
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L
I
A
A
S
I
A
G
A
-
R
L
V
T
L
-
P
-
A
V
H
L
S
N
V
E
F
P
Q
A
F
E
G
A
V
L
S
F
L
G
A
2
PsiBlast_PDB
83.08
38%
-65
- C1 -
-
3OM8
2
?
A:
[12-264]
-----------------
S
D
G
A
S
L
A
Y
R
L
D
G
A
--
A
--
E
K
P
L
L
A
L
S
N
S
I
G
T
T
L
H
M
W
D
A
Q
L
-
P
A
L
T
-
R
H
-
F
R
V
L
R
Y
D
A
R
G
H
G
A
S
-
S
V
P
P
---
G
P
Y
T
L
A
R
L
G
E
D
V
L
E
L
L
D
A
L
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V
R
-
R
A
H
F
L
G
L
S
L
G
G
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V
G
Q
W
L
A
L
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A
P
Q
R
I
E
R
L
V
L
-----------
A
N
T
S
A
W
L
-----------------
G
P
A
A
-----
Q
---
W
D
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R
I
----
A
-
A
----
V
L
-
Q
--
A
----
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D
M
S
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E
---
T
A
----
A
G
----
F
L
G
N
W
F
P
-----
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--
A
L
L
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R
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A
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P
V
V
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----
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R
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M
L
M
-
A
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--
N
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R
--
H
---
G
---
L
--
A
G
----
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------
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------
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A
V
R
---
D
--
T
D
--------
L
R
------
A
Q
L
A
R
I
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R
P
T
L
V
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A
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A
Y
D
T
V
T
A
A
S
H
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L
I
A
A
S
I
A
G
A
-
R
L
V
T
L
-
P
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A
V
H
L
S
N
V
E
F
P
Q
A
F
E
G
A
V
L
S
F
L
--
116
HHSearch
66.01
25%
-12
- C1 -
-
5A62
-
?
A:
[7-268]
----------------
P
S
N
S
V
S
T
Y
Y
E
D
H
G
D
--
A
--
R
S
Y
P
L
V
L
I
H
P
I
G
G
N
I
L
I
W
D
Y
E
I
-
Q
L
L
L
K
S
G
-
F
R
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Y
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L
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G
H
H
R
T
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N
M
G
K
T--
G
A
Y
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D
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I
D
D
L
R
R
L
L
E
H
L
N
I
G
-
K
C
T
I
I
G
H
S
I
G
G
I
I
S
S
M
Y
A
A
Q
H
P
G
K
V
D
A
I
I
M
-----------
I
N
G
S
P
K
K
-----------------
F
Q
E
K
-----
D
---
L
E
K
H
-----
F
-
R
----
T
--
R
--
E
----
V
A
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T
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Q
---
G
M
----
K
A
----
L
A
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H
K
L
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-----
S
LD
E
A
R
D
LF
A
-
D
K
R
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A
D
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----
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------
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A
L
Y
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P
--
G
N
--------
V
V
------
Q
G
L
R
A
S
G
C
K
V
F
A
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V
G
S
D
D
D
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-
R
L
I
K
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T
K
E
E
I
P
E
M
-
E
L
R
V
L
-
Q
G
S
D
H
W
V
V
I
E
K
P
K
E
M
Y
D
I
L
M
G
F
L
A
I
3
PsiBlast_PDB
64.23
28%
-39
- C1 -
-
5EGN
-
?
A:
[2-260]
-------------
P
H
V
E
N
D
G
V
K
I
Y
Y
D
S
Y
G
E
------
G
V
P
I
V
F
L
H
P
F
S
T
N
G
G
I
W
Y
F
Q
T
-
F
P
F
A
-
Q
T
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I
V
I
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G
H
G
R
S
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D
K
P
A
---
T
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Y
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M
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A
D
D
V
V
A
V
L
D
A
L
K
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D
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R
A
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N
S
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G
G
M
I
A
M
Q
L
N
L
D
H
P
Q
R
V
I
G
N
L
I
-----------
L
S
S
G
T
G
L
-----------------
G
E
G
M
P
P
E
A
G
A
---
A
F
Q
N
-----
D
-
Y
----
I
G
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--
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----
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G
L
L
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E
---
G
A
----
V
S
----
A
R
S
K
--------------
R
--
E
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R
P
E
I
L
A
V
----
M
K
A
H
F
S
-
V
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S
--------
N
---
F
--
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----
H
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V
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A
A
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PNGVFAWN
I
K
------
D
R
L
S
S
I
Q
A
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T
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V
A
G
E
E
D
L
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T
T
V
A
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L
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G
A
-
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L
R
V
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D
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V
G
H
F
Y
Q
L
E
R
P
S
E
F
N
E
L
L
R
G
F
V
--
112
HHSearch
64.09
25%
-47
- C1 -
-
5EGN
-
?
H:
[2-259]
-------------
P
H
V
E
N
D
G
V
K
I
Y
Y
D
S
Y
G
------
E
G
V
P
I
V
F
L
H
P
F
S
T
N
G
G
I
W
Y
F
Q
T
-
F
P
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A
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Q
T
-
N
H
V
I
V
I
D
H
R
G
H
G
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K
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A
---
T
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Y
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M
E
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A
D
D
V
V
A
V
L
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A
L
K
V
D
-
R
A
V
F
V
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N
S
I
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G
M
I
A
M
Q
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N
L
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H
P
Q
R
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I
G
N
L
I
-----------
L
S
S
G
T
G
L
-----------------
G
E
G
M
-----
P
---
P
E
A
G
-------
A
----
A
F
-
Q
--
N
----
D
Y
I
G
-
A
---
F
-----
G
G
----
L
L
E
G
A
V
S
-----
A
--
R
S
K
R
--
E
-
R
P
E
I
L
A
V
----
M
K
A
H
F
S
-
V
P
SN
F
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P
--
K
---
H
---
V
--
F
D
AATA
D
------
P
------
N
G
V
F
---
A
--
W
N
--------
I
K
------
D
R
L
S
S
I
Q
A
P
T
L
V
V
A
G
E
E
D
L
V
T
T
V
A
N
N
Q
L
L
A
D
N
I
P
G
A
-
E
L
R
V
I
-
N
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V
G
H
F
Y
Q
L
E
R
P
S
E
F
N
E
L
L
R
G
F
---
111
HHSearch
62.62
25%
-46
- C1 -
-
5EGN
-
?
F:
[2-261]
-------------
P
H
V
E
N
D
G
V
K
I
Y
Y
D
S
Y
G
------
E
G
V
P
I
V
F
L
H
P
F
S
T
N
G
G
I
W
Y
F
Q
T
-
F
P
F
A
-
Q
T
-
N
H
V
I
V
I
D
H
R
G
H
G
R
S
-
D
K
P
A
---
T
G
Y
S
I
M
E
H
A
D
D
V
V
A
V
L
D
A
L
K
V
D
-
R
A
V
F
V
G
N
S
I
G
G
M
I
A
M
Q
L
N
L
D
H
P
Q
R
V
I
G
N
L
I
-----------
L
S
S
G
T
G
L
-----------------
G
E
G
M
-----
P
---
P
E
A
G
-------
A
----
A
F
-
Q
--
N
----
D
Y
I
G
-
A
---
F
-----
G
G
----
L
L
E
G
A
V
S
-----
A
--
R
S
K
R
--
E
-
R
P
E
I
L
A
V
----
M
K
A
H
F
S
-
V
P
SN
F
-
P
--
K
---
H
---
V
--
F
D
AATA
D
------
P
------
N
G
V
F
---
A
--
W
N
--------
I
K
------
D
R
L
S
S
I
Q
A
P
T
L
V
V
A
G
E
E
D
L
V
T
T
V
A
N
N
Q
L
L
A
D
N
I
P
G
A
-
E
L
R
V
I
-
N
D
V
G
H
F
Y
Q
L
E
R
P
S
E
F
N
E
L
L
R
G
F
V
A
-
8
PsiBlast_PDB
60.15
29%
-35
- C1 -
-
4UHF
3
?
A:
[41-268]
---------------------------------------------------
M
W
K
A
Q
R
-
E
E
L
C
-
D
E
-
F
R
V
I
V
P
D
L
R
G
F
G
E
S
-
Q
V
I
P
---
G
V
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
-----------
C
D
T
R
A
R
P
-----------------
D
S
P
E
-----
A
K
E
N
R
R
R
V
-----
A
-
E
----
R
V
-
R
--
R
----
E
G
P
G
-
F
---
I
A
----
E
E
----
M
I
P
R
L
C
C
-----
E
--
S
T
F
R
--
N
-
H
P
E
V
I
E
K
----
I
R
Q
M
I
L
-
S
A
--
P
-
P
--
E
---
G
---
V
--
A
A
----
A
------
A
------
L
G
M
A
E
--
R
--
P
D
--------
S
T
------
D
L
L
P
A
L
S
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
E
A
M
A
R
T
I
P
Q
S
-
Q
F
V
V
I
P
D
-
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
--
6
PsiBlast_PDB
59.99
29%
-31
- C1 -
-
4UHD
1
?
A:
[41-268]
---------------------------------------------------
M
W
K
A
Q
R
-
E
E
L
C
-
D
E
-
F
R
V
I
V
P
D
L
R
G
F
G
E
S
-
Q
V
I
P
---
G
V
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
-----------
C
D
T
R
A
R
P
-----------------
D
S
P
E
-----
A
K
E
N
R
R
R
V
-----
A
-
E
----
R
V
-
R
--
R
----
E
G
P
G
-
F
---
I
A
----
E
E
----
M
I
P
R
L
C
C
-----
E
--
S
T
F
R
--
N
-
H
P
E
V
I
E
K
----
I
R
Q
M
I
L
-
S
A
--
P
-
P
--
E
---
G
---
V
--
A
A
----
A
------
A
------
L
G
M
A
E
--
R
--
P
D
--------
S
T
------
D
L
L
P
A
L
S
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
E
A
M
A
R
T
I
P
Q
S
-
Q
F
V
V
I
P
D
-
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
--
105
HHSearch
59.78
14%
-60
- C1 -
-
4K2A
-
?
C:
[6-287]
-------------
H
H
R
A
V
L
G
S
T
M
A
Y
R
E
T
G
R
--
S
--
D
A
P
H
V
L
F
L
H
G
N
P
T
S
S
Y
I
W
R
N
I
M
-
P
L
V
A
-
P
V
-
G
H
C
I
A
P
D
L
I
G
Y
G
Q
S
-
G
K
P
D
---
I
S
Y
R
F
F
D
Q
A
D
Y
L
D
A
L
I
D
E
L
G
I
A
-
S
A
Y
L
V
A
Q
D
W
G
T
A
L
A
F
H
L
A
A
R
R
P
Q
L
V
R
G
L
A
F
-----------
M
E
F
I
R
P
M
-----------------
R
D
W
S
-----
D
---
F
H
Q
H
DA---
A
R
E
----
T
F
-
R
--
K
FRT-
P
G
V
G
-
E
---
A
M
ILDN
N
A
----
F
V
E
R
V
L
P
-----
G
--
S
I
L
R
T-
L
-
S
E
E
E
M
A
A
----
Y
R
A
P
F
A
-
T
R
--
E
-
S
RM
P
---
T
---
L
ML
P
R
----
E
LPIAGE
P
------
A
D
V
T
---
Q
AL
T
A
--------
A
H
------
A
A
L
A
A
S
T
Y
P
K
L
L
F
V
G
S
P
G
A
L
V
S
P
A
F
A
A
E
F
A
K
T
L
K
H
C
-
A
V
I
Q
L
-
G
A
G
G
H
Y
L
Q
E
D
H
P
E
A
I
G
R
S
V
A
G
W
I
A
G
7
PsiBlast_PDB
59.59
29%
-30
- C1 -
-
4UHE
2
?
A:
[41-268]
---------------------------------------------------
M
W
K
A
Q
R
-
E
E
L
C
-
D
E
-
F
R
V
I
V
P
D
L
R
G
F
G
E
S
-
Q
V
I
P
---
G
V
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
-----------
C
D
T
R
A
R
P
-----------------
D
S
P
E
-----
A
K
E
N
R
R
R
V
-----
A
-
E
----
R
V
-
R
--
R
----
E
G
P
G
-
F
---
I
A
----
E
E
----
M
I
P
R
L
C
C
-----
E
--
S
T
F
R
--
N
-
H
P
E
V
I
E
K
----
I
R
Q
M
I
L
-
S
A
--
P
-
P
--
E
---
G
---
V
--
A
A
----
A
------
A
------
L
G
M
A
E
--
R
--
P
D
--------
S
T
------
D
L
L
P
A
L
S
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
E
A
M
A
R
T
I
P
Q
S
-
Q
F
V
V
I
P
D
-
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
--
4
PsiBlast_PDB
59.50
29%
-32
- C1 -
-
4UHH
2
?
A:
[41-268]
---------------------------------------------------
M
W
K
A
Q
R
-
E
E
L
C
-
D
E
-
F
R
V
I
V
P
D
L
R
G
F
G
E
S
-
Q
V
I
P
---
G
V
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
-----------
C
D
T
R
A
R
P
-----------------
D
S
P
E
-----
A
K
E
N
R
R
R
V
-----
A
-
E
----
R
V
-
R
--
R
----
E
G
P
G
-
F
---
I
A
----
E
E
----
M
I
P
R
L
C
C
-----
E
--
S
T
F
R
--
N
-
H
P
E
V
I
E
K
----
I
R
Q
M
I
L
-
S
A
--
P
-
P
--
E
---
G
---
V
--
A
A
----
A
------
A
------
L
G
M
A
E
--
R
--
P
D
--------
S
T
------
D
L
L
P
A
L
S
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
E
A
M
A
R
T
I
P
Q
S
-
Q
F
V
V
I
P
D
-
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
--
16
PsiBlast_PDB
59.44
25%
-64
- C1 -
-
3V48
3
RUTD_ECOSE
A:
[15-250]
------------------------------------
A
P
V
V
V
L
I
S
G
L
G
G
S
G
S
Y
W
L
P
Q
L
-
A
V
L
E
-
Q
E
-
Y
Q
V
V
C
Y
D
Q
R
G
T
G
N
N
P
D
T
L
A
---
E
D
Y
S
I
A
Q
M
A
A
E
L
H
Q
A
L
V
A
A
G
I
E
-
H
Y
A
V
V
G
H
A
L
G
A
L
V
G
M
Q
L
A
L
D
Y
P
A
S
V
T
V
L
I
S
-----------
V
N
G
W
L
R
I
N
A
H
T
R
R
C
F
Q
V
R
E
R
L
L
Y
S
G
G
A
Q
-----
A
---
W
V
E
A
-----
Q
-
P
----
L
F
-----------
L
Y
-
P
A
D
W
M
A
----
A
R
----
A
P
R
L
E
A
E
-----
D
--
A
L
A
L
--
A
-
H
F
Q
G
K
N
N
----
L
L
R
R
L
N
------------------------------------------
A
L
K
---
R
--
A
D
--------
F
S
------
H
H
A
D
R
I
R
C
P
V
Q
I
I
C
A
S
D
D
L
L
V
P
T
A
C
S
S
E
L
H
A
A
L
P
D
S
Q
K
M
V
M
P
-
Y
-
G
G
H
A
C
N
V
T
D
P
E
T
F
N
---------
5
PsiBlast_PDB
59.37
29%
-35
- C1 -
-
4UHC
-
?
A:
[41-268]
---------------------------------------------------
M
W
K
A
Q
R
-
E
E
L
C
-
D
E
-
F
R
V
I
V
P
D
L
R
G
F
G
E
S
-
Q
V
I
P
---
G
V
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
-----------
C
D
T
R
A
R
P
-----------------
D
S
P
E
-----
A
K
E
N
R
R
R
V
-----
A
-
E
----
R
V
-
R
--
R
----
E
G
P
G
-
F
---
I
A
----
E
E
----
M
I
P
R
L
C
C
-----
E
--
S
T
F
R
--
N
-
H
P
E
V
I
E
K
----
I
R
Q
M
I
L
-
S
A
--
P
-
P
--
E
---
G
---
V
--
A
A
----
A
------
A
------
L
G
M
A
E
--
R
--
P
D
--------
S
T
------
D
L
L
P
A
L
S
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
E
A
M
A
R
T
I
P
Q
S
-
Q
F
V
V
I
P
D
-
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
--
115
HHSearch
58.96
19%
-60
- C1 -
-
5W15
-
?
D:
[15-275]
--------------
R
F
N
F
E
G
H
R
I
A
W
G
T
L
G
------
E
G
P
P
L
V
L
V
H
G
T
P
F
S
S
Q
V
W
R
R
I
A
-
P
W
L
A
-
R
R
-
H
R
V
F
F
Y
D
L
L
G
Y
G
Q
S
-
D
M
P
D
---
A
D
V
S
L
G
R
Q
N
V
L
F
G
A
L
L
D
E
W
K
I
S
-
R
P
R
V
L
A
H
D
Y
G
G
A
T
V
L
R
A
H
F
L
D
G
I
A
Y
S
D
L
T
L
-----------
V
N
P
V
A
I
A
-----------------
P
Q
G
S
-----
P
---
F
V
R
H
-----
V
-
A
----
Q
H
-
E
AA
F
----
T
G
L
P
-
A
Y--
A
H
----
H
A
----
L
V
S
A
Y
I
G
-----
Q
--
A
V
A
Q
--
P
L
S
D
D
V
L
S
I
----
Y
R
A
P
W
L
T
P
A
--
G
-
Q
--
A
---
A
---
F
--
Y
R
----
Q
------
I
------
A
Q
M
R
QRY
I
--
E
D
--------
A
E
------
A
R
Y
A
P
P
D
F
P
V
R
I
V
W
G
E
D
D
R
W
I
P
L
E
Q
G
Q
A
L
A
D
R
I
A
N
G
-
K
L
I
R
V
-
P
R
A
G
H
L
V
Q
E
D
A
P
E
A
I
V
A
A
V
L
D
R
---
106
HHSearch
58.74
13%
-71
- C1 -
-
1CQW
-
DHAA_RHOSD
A:
[8-289]
-----------
D
P
H
Y
V
E
V
L
G
E
R
M
H
Y
V
D
V
G
P
--
R
--
D
G
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
-
P
H
V
A
-
P
S
-
H
R
C
I
A
P
D
L
I
G
M
G
K
S
-
D
K
P
D
---
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
-
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
-----------
M
E
F
I
R
P
I
-----------------
P
T
W
D
-----
E
---
W
P
E
F
-----
A
-
R
E
T
F
Q
A
F
-
R
--
T
----
A
D
V
G
R
E
---
L
I
IDQ-
N
A
----
F
I
E
G
V
L
P
-----
K
--
C
V
V
R
P-
L
-
T
E
V
E
M
D
H
----
Y
R
E
P
F
L
-
K
P
V-
D
-
R
--
E
P
L
W
R
---
F
--
P
N
----
E
------
I
PIAGEP
A
N
I
V
A
L
-
V
--
E
A
--------
Y
M
------
N
W
L
H
Q
S
P
V
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
A
A
R
L
A
E
S
L
P
N
C
-
K
T
V
D
I
-
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
G
107
HHSearch
58.43
23%
-14
- C1 -
-
4Q3L
1
?
G:
[21-290]
-----------
G
V
S
I
F
T
Y
Q
E
K
D
I
Y
Y
E
I
D
G
T
LD
I
--
N
S
D
V
I
V
I
L
N
G
I
M
M
S
T
K
S
W
D
A
F
V
-
E
N
F
S
-
K
N
-
H
V
L
L
R
Y
D
M
F
D
Q
G
Q
S
-
S
K
I
E
---
E
S
Y
T
Q
T
I
Q
V
E
L
L
K
N
L
L
E
H
L
G
I
A
-
Q
A
N
I
V
G
I
S
Y
G
A
S
I
A
L
Q
F
A
A
K
Y
P
T
M
I
K
R
M
V
V
-----------
A
N
V
V
A
K
T
-----------------
S
P
W
L
K----
D
---
I
G
D
G
-----
W
-
N
----
E
V
A
K
--
T
----
G
N
G
L
-
A
---
Y
Y
----
H
I
----
T
I
P
Y
I
Y
S
-----
P
--
Q
F
Y
T
--
L
-
H
N
D
W
M
E
K
RKEL
L
V
P
L
F
S
-
T
R
T-
F
-
L
--
D
---
R
---
M
--
I
R
----
L
------
T
------
K
S
A
E
---
T
--
H
D
--------
V
I
------
K
D
L
P
N
I
K
T
P
T
L
I
I
S
S
E
E
D
Y
L
T
P
P
F
E
Q
K
Y
L
Q
E
H
L
Q
N
A
-
E
L
V
S
I
-
P
N
C
G
H
A
S
M
Y
E
V
P
K
T
F
T
A
L
V
L
G
F
F
G
Q
9
PsiBlast_PDB
58.41
25%
-3
- C1 -
-
1Q0R
2
RDMC_STREF
A:
[2-271]
--------
S
E
R
I
V
P
S
---
G
D
V
E
L
W
S
D
D
F
G
D
--
P
--
A
D
P
A
L
L
L
V
M
G
G
N
L
S
A
L
G
W
P
D
E
F
A
R
R
L
A
-
D
G
G
L
H
V
I
R
Y
D
H
R
D
T
G
R
S
-
T
T
R
D
FAA
H
P
Y
G
F
G
E
L
A
A
D
A
V
A
V
L
D
G
W
G
V
D
-
R
A
H
V
V
G
L
S
M
G
A
T
I
T
Q
V
I
A
L
D
H
H
D
R
L
S
S
L
T
M
L
LGGGLDID
F
D
A
N
I
E
R
V
M
R
GEPTLDGLP-------
G
P
Q
Q
-----
P
---
F
L
D
A
-----
L
-
A
----
L
M
-
N
--
Q
P
A
--
E
G
R
A
-
A
---
E
V
----
A
K
----
R
V
S
K
W
R
I
L
S
GTG
V
--
P
F
D
D
--
A
-
E
Y
A
R
W
E
E
----
R
A
I
D
H
A
-
G
G
--
V
L
A
--
E
---
P
---
Y
--
A
H
----
Y
------
S
------
L
T
L
P
---
P
--
P
S
--------
R
A
------
A
E
L
R
E
V
T
V
P
T
L
V
I
Q
A
E
H
D
P
I
A
P
A
P
H
G
K
H
L
A
G
L
I
P
T
A
-
R
L
A
E
I
--------------------------
113
HHSearch
58.29
20%
-30
- C1 -
-
4INZ
1
?
B:
[21-304]
-------------
Q
Y
I
N
V
N
G
V
N
L
H
Y
I
S
K
G
------
Q
G
E
L
M
L
F
L
H
G
F
P
D
F
S
H
I
W
R
H
Q
I
-
D
E
F
S
-
N
D
-
F
H
T
V
A
L
D
L
R
G
Y
N
L
S
-
E
K
P
S
G
L-
E
S
Y
E
I
D
V
L
V
E
D
I
R
Q
V
I
E
G
L
G
Y
S
-
S
C
T
L
V
V
H
D
W
G
A
G
I
G
W
T
F
A
Y
R
Y
P
E
Y
V
Q
K
L
I
A
-----------
F
N
G
P
H
P
Y
-----------------
T
F
M
R
-----
E
---
L
R
T
N
K
N
Q
Q
K
A
-
S
----
E
Y
-
A
--
K
W
F
Q
K
Q
E
V
Q
-
D
---
Y
M
----
E
R
DNF
S
G
L
R
K
L
V
I
D
----
P
--
G
V
K
K
GY
L
-
T
A
D
D
V
Q
A
----
Y
M
N
S
W
E
-
N
G
--
S
-
V
--
L
---
S
M
L
S
Y
--
Y
R
----
N
------
L
------
K
I
F
T
---
E
--
E
D
--------
L
R
RKSLFP
L
E
E
E
V
L
N
I
P
V
Q
I
I
W
G
N
Q
D
P
T
F
M
P
E
N
L
D
G
I
E
E
Y
V
P
N
I
-
S
V
H
R
L
-
A
E
A
S
H
A
P
Q
H
E
K
P
Q
E
V
N
N
V
M
W
N
F
L
N
K