@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSE7: (2017-12-07 )
MHPIVIIGSGMAGYTLAREFRKLNPEQELVMICADDAVNYAKPTLSNAFAGKKAPEQIPLGDAAKMSAQLNMRIEPFTWVKEILAERHELVLEKDGIISQQPYSKLILAVGANPIRLAIAGDGSDDIHVVNSLIDYRSFRENLAQRKDKRVVILGAGLIGCEFANDLLHSEYDVTVIDLAPQPLGRLLPSHIASAFQQNLEEAGVKFTLGTTVEKVSKINNGEDYAVTLANGQTLVADIVLSAIGLQPNISLAQSANIQTSRGVITNSLLETNQADIYAIGDCAEVNGTLLPYVMPIMQQARALAKTLSGQQTNVHYPAMPVAVKTPAAPLTVLPAPVDVDVNWETEEFDDGMLAKAIDNEGTLRGFVLLGATAGKQRLTLTKLVPDLIPAQA
Atome Classification :
(20 SA)
.........10........20........30........40.....-...-50...-.-....60........70........80........90...--.--....100.......110......-.120.---......130.......140.......150.......160.......170.......180.......190.......200.......210.......220----------------...-.-....230.......240.......250.......260.--........270.......280.......------290----.......------..300.......310-.....-..320-.-.-.....330.......340.----.-------.-------------.--.---------..--350..-......360.......370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MH
P
I
V
I
IGSGMA
G
Y
T
L
A
R
E
F
R
KLNPE
Q
E
L
V
M
I
CADDAVNYAKPTLS-NAF-AGKKA-P-EQIPLG
D
A
A
K
M
S
A
Q
L
N
MRIE
P
F
T
W
V
K
E
I
L
A
E
R
H
E
L
V
LEK--D--GIISQQPY
S
K
L
I
L
A
VGA
N
P
I
R
L
A
-
I
AGDG---SD
D
I
H
V
V
N
S
L
I
D
Y
R
S
F
R
E
N
L
A
QRKD
K
R
V
V
I
L
GAG
L
I
G
C
E
F
A
N
D
L
LHSEY
D
V
T
V
I
DLAP
Q
P
L
G
R
L
L
P
S
H
I
A
S
A
F
Q
Q
N
L
E
EAG
V
K
F
TLG
T
T
V
E
K
V
S
KINN-----------------GE
D
-
Y
-
A
V
T
LANG
Q
T
L
V
A
D
I
V
L
S
A
IGLQPNISLAQSANIQT--S--RG
V
I
T
N
S
L
LETNQA
D
I
Y
A
IGDCAEVNGT------
L
------
L
P
Y
V
M
P
I
------
M
Q
Q
A
R
A
L
A
K
T
LSGQQ-TNVHY-PAM
P
V
-
A
-V-KTPAA
P
L
T
VLPA
P
V
D
V
D
VN----W-------E-------------T--E---------EF--D-D
G
M
-
L
A
K
AIDNEG
T
L
R
G
F
V
L
L
GATAGK
Q
R
L
T
L
T
K
L
V
P
D
LIPAQA
37
HHSearch
97.81
43%
-131
- C1 -
-
2V3A
7
RURE_PSEAE
A:
[4-384]
R
A
P
L
V
I
I
G
T
G
L
A
G
Y
N
L
A
R
E
W
R
K
L
D
G
E
T
P
L
L
M
I
T
A
D
D
G
R
S
Y
S
K
P
M
L
S
-
T
G
F
-
S
K
N
K
D
-
A
-
D
G
L
A
M
A
E
P
G
A
M
A
E
Q
L
N
A
R
I
L
T
H
T
R
V
T
G
I
D
P
G
H
Q
R
I
W
I
G
---
E
-----
E
E
V
R
Y
R
D
L
V
L
A
W
G
A
E
P
I
R
V
P
-
V
E
G
D
A
---
Q
D
A
L
Y
P
I
N
D
L
E
D
Y
A
R
F
R
Q
A
A
A
G
--
K
R
R
V
L
L
L
G
A
G
L
I
G
C
E
F
A
N
D
L
S
S
G
G
Y
Q
L
D
V
V
A
P
C
E
Q
V
M
P
G
L
L
H
P
A
A
A
K
A
V
Q
A
G
L
E
G
L
G
V
R
F
H
L
G
P
V
L
A
S
L
K
K
A
-------------------
G
E
G
-
L
-
E
A
H
L
S
D
G
E
V
I
P
C
D
L
V
V
S
A
V
G
L
R
P
R
T
E
L
A
F
A
A
G
L
A
V
--
N
--
R
G
I
V
V
D
R
S
L
R
T
S
H
A
N
I
Y
A
L
G
D
C
A
E
V
D
G
L
------
N
------
L
L
Y
V
M
P
L
------
M
A
C
A
R
A
L
A
Q
T
L
A
G
N
P
-
S
Q
V
A
Y
-
G
P
M
P
V
-
T
-
V
-
K
T
P
A
C
P
L
V
V
S
P
P
P
R
G
M
D
G
Q
----
W
-------
L
-------------
V
--
E
---------
G
---
S
-
G
T
D
L
K
V
L
C
R
D
T
A
G
R
V
I
G
Y
A
L
T
G
A
A
-
V
N
E
K
L
A
L
N
K
E
L
P
G
L
M
A
---
36
HHSearch
97.01
43%
-135
- C1 -
-
2V3B
1
RURE_PSEAE
A:
[4-384]
R
A
P
L
V
I
I
G
T
G
L
A
G
Y
N
L
A
R
E
W
R
K
L
D
G
E
T
P
L
L
M
I
T
A
D
D
G
R
S
Y
S
K
P
M
L
S
-
T
G
F
-
S
K
N
K
D
-
A
-
D
G
L
A
M
A
E
P
G
A
M
A
E
Q
L
N
A
R
I
L
T
H
T
R
V
T
G
I
D
P
G
H
Q
R
I
W
I
G
---
E
-----
E
E
V
R
Y
R
D
L
V
L
A
W
G
A
E
P
I
R
V
P
-
V
E
G
D
A
---
Q
D
A
L
Y
P
I
N
D
L
E
D
Y
A
R
F
R
Q
A
A
A
G
--
K
R
R
V
L
L
L
G
A
G
L
I
G
C
E
F
A
N
D
L
S
S
G
G
Y
Q
L
D
V
V
A
P
C
E
Q
V
M
P
G
L
L
H
P
A
A
A
K
A
V
Q
A
G
L
E
G
L
G
V
R
F
H
L
G
P
V
L
A
S
L
K
K
A
-------------------
G
E
G
-
L
-
E
A
H
L
S
D
G
E
V
I
P
C
D
L
V
V
S
A
V
G
L
R
P
R
T
E
L
A
F
A
A
G
L
A
V
--
N
--
R
G
I
V
V
D
R
S
L
R
T
S
H
A
N
I
Y
A
L
G
D
C
A
E
V
D
G
L
------
N
------
L
L
Y
V
M
P
L
------
M
A
C
A
R
A
L
A
Q
T
L
A
G
N
P
-
S
Q
V
A
Y
-
G
P
M
P
V
-
T
-
V
-
K
T
P
A
C
P
L
V
V
S
P
P
P
R
G
M
D
G
Q
----
W
-------
L
-------------
V
--
E
---------
G
---
S
-
G
T
D
L
K
V
L
C
R
D
T
A
G
R
V
I
G
Y
A
L
T
G
A
A
-
V
N
E
K
L
A
L
N
K
E
L
P
G
L
M
A
---
1
PsiBlast_PDB
95.87
42%
-139
- C1 -
-
2V3A
7
RURE_PSEAE
A:
[6-383]
--
P
L
V
I
I
G
T
G
L
A
G
Y
N
L
A
R
E
W
R
K
L
D
G
E
T
P
L
L
M
I
T
A
D
D
G
R
S
Y
S
K
P
M
L
S
-
T
G
F
-
S
K
N
K
D
-
A
-
D
G
L
A
M
A
E
P
G
A
M
A
E
Q
L
N
A
R
I
L
T
H
T
R
V
T
G
I
D
P
G
H
Q
R
I
W
I
G
E
--
E
------
E
V
R
Y
R
D
L
V
L
A
W
G
A
E
P
I
R
V
P
-
V
E
G
D
A
---
Q
D
A
L
Y
P
I
N
D
L
E
D
Y
A
R
F
R
Q
A
A
A
G
K
R
--
R
V
L
L
L
G
A
G
L
I
G
C
E
F
A
N
D
L
S
S
G
G
Y
Q
L
D
V
V
A
P
C
E
Q
V
M
P
G
L
L
H
P
A
A
A
K
A
V
Q
A
G
L
E
G
L
G
V
R
F
H
L
G
P
V
L
A
S
L
K
K
A
-------------------
G
E
G
-
L
-
E
A
H
L
S
D
G
E
V
I
P
C
D
L
V
V
S
A
V
G
L
R
P
R
T
E
L
A
F
A
A
G
L
A
V
--
N
--
R
G
I
V
V
D
R
S
L
R
T
S
H
A
N
I
Y
A
L
G
D
C
A
E
V
D
G
L
------
N
------
L
L
Y
V
M
P
L
------
M
A
C
A
R
A
L
A
Q
T
L
A
G
N
P
-
S
Q
V
A
Y
-
G
P
M
P
V
-
T
-
V
-
K
T
P
A
C
P
L
V
V
S
P
P
P
R
G
M
D
G
Q
----
W
-------
L
-------------
V
--
E
---------
G
S
--
G
-
T
D
L
-
K
V
L
C
R
D
T
A
G
R
V
I
G
Y
A
L
T
G
A
-
A
V
N
E
K
L
A
L
N
K
E
L
P
G
L
M
----
2
PsiBlast_PDB
95.13
42%
-144
- C1 -
-
2V3B
1
RURE_PSEAE
A:
[6-383]
--
P
L
V
I
I
G
T
G
L
A
G
Y
N
L
A
R
E
W
R
K
L
D
G
E
T
P
L
L
M
I
T
A
D
D
G
R
S
Y
S
K
P
M
L
S
-
T
G
F
-
S
K
N
K
D
-
A
-
D
G
L
A
M
A
E
P
G
A
M
A
E
Q
L
N
A
R
I
L
T
H
T
R
V
T
G
I
D
P
G
H
Q
R
I
W
I
G
E
--
E
------
E
V
R
Y
R
D
L
V
L
A
W
G
A
E
P
I
R
V
P
-
V
E
G
D
A
---
Q
D
A
L
Y
P
I
N
D
L
E
D
Y
A
R
F
R
Q
A
A
A
G
K
R
--
R
V
L
L
L
G
A
G
L
I
G
C
E
F
A
N
D
L
S
S
G
G
Y
Q
L
D
V
V
A
P
C
E
Q
V
M
P
G
L
L
H
P
A
A
A
K
A
V
Q
A
G
L
E
G
L
G
V
R
F
H
L
G
P
V
L
A
S
L
K
K
A
-------------------
G
E
G
-
L
-
E
A
H
L
S
D
G
E
V
I
P
C
D
L
V
V
S
A
V
G
L
R
P
R
T
E
L
A
F
A
A
G
L
A
V
--
N
--
R
G
I
V
V
D
R
S
L
R
T
S
H
A
N
I
Y
A
L
G
D
C
A
E
V
D
G
L
------
N
------
L
L
Y
V
M
P
L
------
M
A
C
A
R
A
L
A
Q
T
L
A
G
N
P
-
S
Q
V
A
Y
-
G
P
M
P
V
-
T
-
V
-
K
T
P
A
C
P
L
V
V
S
P
P
P
R
G
M
D
G
Q
----
W
-------
L
-------------
V
--
E
---------
G
S
--
G
-
T
D
L
-
K
V
L
C
R
D
T
A
G
R
V
I
G
Y
A
L
T
G
A
-
A
V
N
E
K
L
A
L
N
K
E
L
P
G
L
M
----
47
HHSearch
66.58
23%
-114
- C1 -
-
3EF6
8
TODA_PSEP1
A:
[3-370]
-
T
H
V
A
I
I
G
N
G
V
G
G
F
T
T
A
Q
A
L
R
A
E
G
F
E
G
R
I
S
L
I
G
D
E
P
H
L
P
Y
D
R
P
S
L
S
-
K
A
V
-
L
D
G
S
L
-
E
-
R
P
P
I
L
A
-
E
A
D
W
Y
G
E
A
R
I
D
M
L
T
G
P
E
V
T
A
L
D
V
Q
T
R
T
I
S
L
D
D
--
G
-----
T
T
L
S
A
D
A
I
V
I
A
T
G
S
R
A
R
T
M
A
-
L
P
G
S
Q
---
L
P
G
V
V
T
L
R
T
Y
G
D
V
Q
V
L
R
D
S
W
T
S
--
A
T
R
L
L
I
V
G
G
G
L
I
G
C
E
V
A
T
T
A
R
K
L
G
L
S
V
T
I
L
E
A
G
D
E
L
L
V
R
V
L
G
R
R
I
G
A
W
L
R
G
L
L
T
E
L
G
V
Q
V
E
L
G
T
G
V
V
G
F
S
G
E
-------------------
G
Q
L
-
E
-
Q
V
M
A
S
D
G
R
S
F
V
A
D
S
A
L
I
C
V
G
A
E
P
A
D
Q
L
A
R
Q
A
G
L
A
C
--
D
--
R
G
V
I
V
D
H
C
G
A
T
L
A
K
G
V
F
A
V
G
D
V
A
S
W
P
L
R
A
G
G
R
R
-
S
------
L
E
T
Y
M
N
A
------
Q
R
Q
A
A
A
V
A
A
A
I
L
G
K
N
-
V
S
A
---
P
Q
L
P
V
S
W
-
T
-
E
I
A
G
H
R
M
Q
M
A
G
D
I
E
G
P
G
D
-----
F
-------
V
-------------
S
--
R
---------
G
M
--
P
G
S
G
A
-
A
L
L
F
R
L
Q
E
R
R
I
Q
A
V
V
A
V
D
A
P
--------------------
46
HHSearch
65.02
23%
-110
- C1 -
-
4EMJ
1
TODA_PSEP1
A:
[2-370]
A
T
H
V
A
I
I
G
N
G
V
G
G
F
T
T
A
Q
A
L
R
A
E
G
F
E
G
R
I
S
L
I
G
D
E
P
H
L
P
Y
D
R
P
S
L
S
-
K
A
V
-
L
D
G
S
L
-
E
-
R
P
P
I
L
A
-
E
A
D
W
Y
G
E
A
R
I
D
M
L
T
G
P
E
V
T
A
L
D
V
Q
T
R
T
I
S
L
D
D
--
G
-----
T
T
L
S
A
D
A
I
V
I
A
T
G
S
R
A
R
T
M
A
-
L
P
G
S
Q
---
L
P
G
V
V
T
L
R
T
Y
G
D
V
Q
V
L
R
D
S
W
T
S
--
A
T
R
L
L
I
V
G
G
G
L
I
G
C
E
V
A
T
T
A
R
K
L
G
L
S
V
T
I
L
E
A
G
D
E
L
L
V
R
V
L
G
R
R
I
G
A
W
L
R
G
L
L
T
E
L
G
V
Q
V
E
L
G
T
G
V
V
G
F
S
G
E
-------------------
G
Q
L
-
E
-
Q
V
M
A
S
D
G
R
S
F
V
A
D
S
A
L
I
C
V
G
A
E
P
A
D
Q
L
A
R
Q
A
G
L
A
C
--
D
--
R
G
V
I
V
D
H
C
G
A
T
L
A
K
G
V
F
A
V
G
D
V
A
S
W
P
L
R
AGGRR-
S
------
L
E
T
Y
M
N
A
------
Q
R
Q
A
A
A
V
A
A
A
I
L
G
K
N
-
V
S
A
---
P
Q
L
P
V
S
W
-
T
-
E
I
A
G
H
R
M
Q
M
A
G
D
I
E
G
P
G
D
-----
F
-------
V
-------------
S
--
R
---------
G
M
--
P
G
S
G
A
-
A
L
L
F
R
L
Q
E
R
R
I
Q
A
V
V
A
V
D
A
P
--------------------
42
HHSearch
63.07
24%
-12
- C1 -
-
3NTD
2
?
A:
[1-430]
M
K
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
F
A
N
C
G
L
P
-
Y
H
I
-
S
G
E
I
A
Q
R
-
S
A
L
V
L
Q
T
P
E
S
F
K
A
R
F
N
V
E
V
R
V
K
H
E
V
V
A
I
D
R
A
A
K
L
V
T
V
R
R
LL
D
--
G
S
E
Y
Q
E
S
Y
D
T
L
L
L
S
P
G
A
A
P
I
V
P
P
-
I
P
G
V
D
---
N
P
L
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
Q
M
N
N
V
E
H
A
T
V
V
G
G
G
F
I
G
L
E
M
M
E
S
L
H
H
L
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
P
V
-
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
R
L
G
T
A
L
S
E
V
S
Y
Q
V
Q
T
H
V
A
S
DAAGEDTAHQHI
K
G
H
-
L
-
S
L
T
L
S
N
G
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
D
A
G
L
A
I
--
G
EL
G
G
I
K
V
N
A
M
M
Q
T
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
VTG
Q
A
C
L
------
V
P
L
A
G
P
A
------
N
R
Q
G
R
M
A
A
D
N
M
F
G
R
E
-
E
R
Y
Q
G
T
Q
G
T
A
I
-
C
---
K
V
F
D
L
A
V
G
A
T
G
K
N
E
K
Q
L
K
Q
----
A
G
I
A
F
---
E
K
V
Y
----------
V
--
H
TASHASYYP
G
A
--
E
-
V
V
S
F
K
L
L
F
D
P
V
K
G
T
I
F
G
A
Q
A
V
G
K
D
G
I
D
K
R
I
D
V
M
A
V
A
Q
-------
53
HHSearch
61.13
21%
-15
- C1 -
-
3ICS
4
?
B:
[36-446]
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
R
L
S
E
E
D
E
I
I
M
V
E
R
G
E
Y
I
S
F
A
N
C
G
L
P
-
Y
Y
I
-
G
G
V
I
T
-
E
R
Q
K
L
L
V
Q
T
V
E
R
M
S
K
R
F
N
L
D
I
R
V
L
S
E
V
V
K
I
N
K
E
E
K
T
I
T
I
K
N
--
V
TT
N
E
T
Y
N
E
A
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
P
S
-
I
P
G
I
E
E--
A
K
A
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
D
E
K
K
P
R
H
A
T
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
R
E
R
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
P
I
D
-
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
V
F
E
D
G
V
D
A
L
E
E
N
---------------------
G
-
A
-
V
V
R
L
K
S
G
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
A
K
G
A
G
L
A
L
--
G
VR
G
T
I
K
V
N
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
VTE
T
E
T
M
------
I
P
L
A
W
P
A
------
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
T
D
S
L
Y
K
G
-
T
L
G
T
S
-
V
-
A
-
K
V
F
D
L
T
V
A
T
T
G
L
N
E
K
I
L
K
R
L
N
I
P
Y
E
V
V
----
H
-------------
V
--
Q
A
N
SHAGYYP
N
A
--
T
-
P
V
L
I
K
L
I
F
N
K
D
S
G
K
I
Y
G
A
Q
T
L
G
R
D
G
V
D
K
R
M
D
V
I
A
T
A
I
-------
52
HHSearch
60.77
21%
-18
- C1 -
-
3ICT
3
?
A:
[36-446]
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
R
L
S
E
E
D
E
I
I
M
V
E
R
G
E
Y
I
S
F
A
N
C
G
L
P
-
Y
Y
I
-
G
G
V
I
T
-
E
R
Q
K
L
L
V
Q
T
V
E
R
M
S
K
R
F
N
L
D
I
R
V
L
S
E
V
V
K
I
N
K
E
E
K
T
I
T
I
K
N
--
V
TT
N
E
T
Y
N
E
A
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
P
S
-
I
P
G
I
E
E--
A
K
A
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
D
E
K
K
P
R
H
A
T
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
R
E
R
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
P
I
D
-
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
V
F
E
D
G
V
D
A
L
E
E
N
---------------------
G
-
A
-
V
V
R
L
K
S
G
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
A
K
G
A
G
L
A
L
--
G
VR
G
T
I
K
V
N
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
VTE
T
E
T
M
------
I
P
L
A
W
P
A
------
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
T
D
S
L
Y
K
G
-
T
L
G
T
S
-
V
-
A
-
K
V
F
D
L
T
V
A
T
T
G
L
N
E
K
I
L
K
R
L
N
I
P
Y
E
V
V
----
H
-------------
V
--
Q
A
N
SHAGYYP
N
A
--
T
-
P
V
L
I
K
L
I
F
N
K
D
S
G
K
I
Y
G
A
Q
T
L
G
R
D
G
V
D
K
R
M
D
V
I
A
T
A
I
-------
57
HHSearch
60.60
26%
-28
- C1 -
-
1Q1W
1
CAMA_PSEPU
A:
[4-380]
N
D
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
K
A
Y
L
-
A
G
K
A
T
-
A
-
E
S
L
Y
L
-
R
T
P
D
A
Y
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
S
D
--
G
-----
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
P
-
V
A
S
G
A
VGK
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
I
A
--
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
Q
V
C
G
F
E
M
S
T
D
-----------------
Q
Q
K
V
T
-
A
V
L
C
E
D
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
--
D
--
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
------
L
YD
R
W
V
R
I
E
S
V
P
N
A
------
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
V
--
P
-
R
D
-
E
A
A
P
W
F
W
-
S
-
D
Q
Y
E
I
G
L
K
M
V
G
L
S
E
G
Y
D
R
I
----
I
---------------------
V
--
R
---------
G
S
LA
Q
-
P
D
F
-
S
V
F
Y
L
-
Q
G
D
R
V
L
A
V
D
T
V
N
R
P
--------------------
44
HHSearch
59.56
20%
-125
- C1 -
-
3KLJ
1
NROR_CLOAB
A:
[9-356]
S
T
K
I
L
I
L
G
A
G
P
A
G
F
S
A
A
K
A
A
L
G
K
C
--
D
D
I
T
M
I
N
S
E
K
Y
L
P
Y
Y
R
P
R
L
N
-
E
I
I
-
A
K
N
K
S
-
I
-
D
D
I
L
-
I
K
K
N
D
W
Y
E
K
N
N
I
K
V
I
T
S
E
F
A
T
S
I
D
P
N
N
K
L
V
T
L
K
S
--
G
-----
E
K
I
K
Y
E
K
L
I
I
A
S
G
S
I
A
N
K
I
K
-
V
P
H
A
-----
D
E
I
F
S
L
Y
S
Y
D
D
A
L
K
I
K
D
E
C
K
N
--
K
G
K
A
F
I
I
G
G
G
I
L
G
I
E
L
A
Q
A
I
I
D
S
G
T
P
A
S
I
G
I
I
L
E
Y
P
L
E
R
Q
L
D
R
D
G
G
L
F
L
K
D
K
L
D
R
L
G
I
K
I
Y
T
N
S
N
F
E
E
M
----------------------------------
G
D
L
I
R
S
S
C
V
I
T
A
V
G
V
K
P
N
L
D
F
I
K
D
T
E
I
A
S
--
K
--
R
G
I
L
V
N
D
H
M
E
T
S
I
K
D
I
Y
A
C
G
D
V
A
E
F
Y
G
K
------
N
------
P
G
L
I
N
I
A
------
N
K
Q
G
E
V
A
G
L
N
A
C
G
E
D
-
A
S
Y
S
E
-
I
I
P
S
P
-
I
-
L
-
K
V
S
G
I
S
I
I
S
C
G
D
I
E
N
N
K
P
S
----
K
-------
V
-------------
F
R
-
S
---------
T
Q
--
E
-
D
K
Y
-
I
V
C
M
L
K
-
E
N
K
I
D
A
A
A
V
I
G
D
V
--------------------
49
HHSearch
59.15
20%
-68
- C1 -
-
4FX9
3
CDR_PYRHO
B:
[6-409]
K
K
K
V
V
I
I
G
G
G
A
A
G
M
S
A
A
S
R
V
K
R
L
K
P
E
W
D
V
K
V
F
E
A
T
E
W
V
S
H
A
P
C
G
I
P
-
Y
V
V
-
E
G
L
S
T
-
P
-
D
K
L
M
Y
Y
P
P
E
V
F
I
K
K
R
G
I
D
L
H
L
N
A
E
V
I
E
V
D
T
G
Y
V
R
V
R
E
N
G
--
G
----
E
K
S
Y
E
W
D
Y
L
V
F
A
N
G
A
S
P
Q
V
P
A
-
I
E
G
V
N
---
L
K
G
V
F
T
A
D
L
P
P
D
A
L
A
I
R
E
Y
M
E
K
Y
K
V
E
N
V
V
I
I
G
G
G
Y
I
G
I
E
M
A
E
A
F
A
A
Q
G
K
N
V
T
M
I
V
R
G
E
R
V
L
R
R
S
F
D
K
E
V
T
D
I
L
E
E
K
L
K
K
-
H
V
N
L
R
L
Q
E
I
T
M
K
I
E
G
E
--------------------
E
R
-
V
-
E
K
V
V
T
D
A
G
E
Y
K
A
E
L
V
I
L
A
T
G
I
K
P
N
I
E
L
A
K
Q
L
G
V
R
I
--
G
ET
G
A
I
W
T
N
E
K
M
Q
T
S
V
E
N
V
Y
A
A
G
D
V
A
E
T
R
H
V
ITG
R
R
V
W
------
V
P
L
A
P
A
G
------
N
K
M
G
Y
V
A
G
S
N
I
A
G
K
E
-
L
H
F
P
G
-
V
L
G
T
A
-
V
-
T
-
K
F
M
D
V
E
I
G
K
T
G
L
T
E
M
E
A
L
K
----
E
GY-----
D
V
R
T
A
F
I
K
A
S
TRPH
Y
--
Y
P--------
G
G
--
R
-
E
I
W
L
K
G
V
V
D
N
E
T
N
R
L
L
G
V
Q
V
V
G
S
D
-
I
L
P
R
I
D
T
A
A
A
M
L
-------
41
HHSearch
57.73
20%
-92
- C1 -
-
3OC4
1
?
A:
[3-404]
-
L
K
I
V
I
I
G
A
S
F
A
G
I
S
A
A
I
A
S
R
K
K
Y
P
Q
A
E
I
S
L
I
D
K
Q
A
T
V
G
Y
L
S
G
-------------------
R
-
Y
I
T
E
E
E
L
R
R
Q
K
I
Q
L
L
L
N
R
E
V
V
A
M
D
V
E
N
Q
L
I
A
W
T
R
--
K
--
E
E
Q
Q
W
Y
S
Y
D
K
L
I
L
A
T
G
A
S
Q
F
S
T
Q
-
I
R
G
S
Q
---
T
E
K
L
L
K
Y
K
F
L
S
----
A
V
P
L
L
E
N
--
S
Q
T
V
A
V
I
G
A
G
P
I
G
M
E
A
I
D
F
L
V
K
M
K
K
T
V
H
V
F
E
S
L
E
N
L
L
P
K
Y
F
D
K
E
M
V
A
E
V
Q
K
S
L
E
K
Q
A
V
I
F
H
F
E
E
T
V
L
G
I
E
E
T
-
A
------------------
N
G
-
I
-
V
L
E
-
T
S
E
Q
E
I
S
C
D
S
G
I
F
A
L
N
L
H
P
Q
L
A
Y
L
D
K
-
K
I
Q
R
N
L
D
--
Q
T
I
A
V
D
A
Y
L
Q
T
S
V
P
N
V
F
A
I
G
D
C
I
S
V
M
N
E
------
P
VA
E
T
F
Y
A
P
L
V
N
N
A
------
V
R
T
G
L
V
V
A
N
N
L
E
E
K
T
-
H
R
F
I
G
-
S
L
R
T
M
-
G
-
T
-
K
V
G
D
Y
Y
L
A
S
T
G
L
T
E
T
E
G
L
F
----
F
PQT
L
A
S
I
I
-------------
V
--
R
Q
P
A
PPLQ--
H
G
--
T
-
E
I
L
G
K
L
I
Y
D
K
V
T
Q
R
V
L
G
A
Q
L
C
S
K
N
N
C
L
E
K
I
N
T
L
A
L
S
I
-------
3
PsiBlast_PDB
57.70
29%
-40
- C1 -
-
1Q1R
1
CAMA_PSEPU
A:
[7-319]
---
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
-
K
A
Y
L
A
G
K
A
T
-
A
-
E
S
L
Y
L
R
T
P
D
A
Y
A
A
Q
-
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
-
S
--
D
--
G
--
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
P
-
V
A
S
G
A
VGK
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
I
--
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
Q
V
C
G
F
E
M
S
T
D
-----------------
Q
Q
K
-
V
T
A
V
L
C
E
D
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
--
D
--
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
------
L
------
Y
D
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
57.38
20%
-65
- C1 -
-
4FX9
3
CDR_PYRHO
A:
[6-409]
K
K
K
V
V
I
I
G
G
G
A
A
G
M
S
A
A
S
R
V
K
R
L
K
P
E
W
D
V
K
V
F
E
A
T
E
W
V
S
H
A
P
C
G
I
P
-
Y
V
V
-
E
G
L
S
T
-
P
-
D
K
L
M
Y
Y
P
P
E
V
F
I
K
K
R
G
I
D
L
H
L
N
A
E
V
I
E
V
D
T
G
Y
V
R
V
R
--
G
--
G
----
E
K
S
Y
E
W
D
Y
L
V
F
A
N
G
A
S
P
Q
V
P
A
-
I
E
G
V
N
---
L
K
G
V
F
T
A
D
L
P
P
D
A
L
A
I
R
E
Y
M
E
K
Y
K
V
E
N
V
V
I
I
G
G
G
Y
I
G
I
E
M
A
E
A
F
A
A
Q
G
K
N
V
T
M
I
V
R
G
E
R
V
L
R
R
S
F
D
K
E
V
T
D
I
L
E
E
K
L
K
K
-
H
V
N
L
R
L
Q
E
I
T
M
K
I
E
G
E
--------------------
E
R
-
V
-
E
K
V
V
T
D
A
G
E
Y
K
A
E
L
V
I
L
A
T
G
I
K
P
N
I
E
L
A
K
Q
L
G
V
R
I
--
G
ET
G
A
I
W
T
N
E
K
M
Q
T
S
V
E
N
V
Y
A
A
G
D
V
A
E
T
R
H
V
ITG
R
R
V
W
------
V
P
L
A
P
A
G
------
N
K
M
G
Y
V
A
G
S
N
I
A
G
K
E
-
L
H
F
P
G
-
V
L
G
T
A
-
V
-
T
-
K
F
M
D
V
E
I
G
K
T
G
L
T
E
M
E
A
L
K
----
E
GY-----
D
V
R
T
A
F
I
K
A
S
TRPH
Y
--
Y
P--------
G
G
--
R
-
E
I
W
L
K
G
V
V
D
N
E
T
N
R
L
L
G
V
Q
V
V
G
S
D
-
I
L
P
R
I
D
T
A
A
A
M
L
-------
45
HHSearch
57.12
22%
-51
- C1 -
-
2GR3
3
?
A:
[7-371]
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
-
K
D
F
-
M
A
H
G
D
-
A
-
E
K
I
R
----
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
--
G
-----
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
L
Q
G
A
T
----
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
--
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
G
-------------------------
V
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
--
D
--
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
LSGRFE
R
------
I
E
T
W
S
N
A
------
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
T
--
A
P
G
Y
-
A
E
L
P
W
-
Y
-
F
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
S
G
D
E
E
I
----
V
-------
R
-------------
G
--
E
VS-------
L
D
--
A
-
P
K
F
-
T
L
I
E
L
-
Q
K
G
R
I
V
G
A
T
C
V
N
N
A
--------------------
43
HHSearch
56.33
22%
-54
- C1 -
-
4H4R
12
?
A:
[7-371]
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
P
L
S
-
K
D
F
-
M
A
H
G
D
-
A
-
E
K
I
----
R
L
D
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
--
G
-----
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
L
Q
G
A
T
----
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
R
P
--
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
A
G
V
H
V
S
L
V
C
T
G
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
G
-------------------------
V
V
L
L
D
D
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
--
D
--
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
------
L
SGRFER
I
E
T
W
S
N
A
------
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
T
--
A
P
G
Y
-
A
E
L
P
W
-
Y
W
S
-
D
Q
G
A
L
R
I
Q
V
A
G
L
A
S
G
D
E
E
I
----
V
-------
R
-------------
G
EV
S
---------
L
D
--
A
-
P
K
F
-
T
L
I
E
L
-
Q
K
G
R
I
V
G
A
T
C
V
N
N
A
--------------------
5
PsiBlast_PDB
56.30
29%
-40
- C1 -
-
3LB8
1
CAMA_PSEPU
A:
[6-318]
---
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
-
K
A
Y
L
A
G
K
A
T
-
A
-
E
S
L
Y
L
R
T
P
D
A
Y
A
A
Q
-
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
-
S
--
D
--
G
--
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
P
-
V
A
S
G
A
VGK
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
I
--
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
Q
V
C
G
F
E
M
S
T
D
-----------------
Q
Q
K
-
V
T
A
V
L
C
E
D
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
--
D
--
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
------
L
------
Y
D
R
W
V
R
I
ES
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
55.83
29%
-39
- C1 -
-
1Q1W
1
CAMA_PSEPU
A:
[7-319]
---
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
-
K
A
Y
L
A
G
K
A
T
-
A
-
E
S
L
Y
L
R
T
P
D
A
Y
A
A
Q
-
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
-
S
--
D
--
G
--
R
A
L
D
Y
D
R
L
V
L
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T
G
G
R
P
R
P
L
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-
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VGK
A
N
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F
R
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L
R
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L
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A
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C
I
R
R
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--
A
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R
L
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V
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G
G
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I
G
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A
A
T
A
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L
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V
C
G
F
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M
S
T
D
-----------------
Q
Q
K
-
V
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A
V
L
C
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G
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C
A
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F
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------
L
------
Y
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W
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V
P
N
A
L
E
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K
I
A
A
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L
C
G
K
------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
54.49
20%
-87
- C1 -
-
3OC4
1
?
B:
[2-404]
S
L
K
I
V
I
I
G
A
S
F
A
G
I
S
A
A
I
A
S
R
K
K
Y
P
Q
A
E
I
S
L
I
D
K
Q
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T
V
G
Y
L
S
G
------------------
A
R
-
Y
I
T
E
E
E
L
R
R
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K
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Q
L
L
L
N
R
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V
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A
W
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--
K
--
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W
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L
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L
A
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A
S
Q
F
S
T
Q
-
I
R
G
S
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---
T
E
K
L
L
K
Y
K
F
------
A
V
P
L
L
E
N
--
S
Q
T
V
A
V
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G
A
G
P
I
G
M
E
A
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F
L
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L
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K
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V
I
F
H
F
E
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T
V
L
G
I
E
E
T
-
A
------------------
N
G
-
I
-
V
L
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-
T
S
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Q
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S
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V
P
N
V
F
A
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G
D
C
I
S
V
M
N
E
------
P
VA
E
T
F
Y
A
P
L
V
N
N
A
------
V
R
T
G
L
V
V
A
N
N
L
E
E
K
T
-
H
R
F
I
G
-
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-
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D
Y
Y
L
A
S
T
G
L
T
E
T
E
G
L
F
----
F
P
Q
T
L
A
S
I
I
-------------
V
--
R
Q
P
A
PP----
H
G
--
T
-
E
I
L
G
K
L
I
Y
D
K
V
T
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V
L
G
A
Q
L
C
S
K
N
N
C
L
E
K
I
N
T
L
A
L
S
I
-------