@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTH1: (2017-12-13 )
MKSFKVALAQFSPHIGNIDSNTQKMIEQANQAKKQDADLIIFPELSVIGYPAEDLLLRPNLNKRMQKAFAQLSEVKDIVMVFGFVNQTEDGQRYNSAAVMKDGQVLGVFNKHNLPNYGVFDEKRYFQKGHQHLVFEYLGHKFGVLICEDIWSINTVKQLSQLNVDTVLVLNSSPYEVGKPQHRKQTLSELAKQLHLNTVYVNQVGGQDDLIFDGTSFVSNQNGEIALQAPSFKEDLYIAEFDRDTKLYKVVESAPALETFAEIYQGLVMATRDYVERSGFPGVILGLSGGIDSALTLAIAVDAIGAERVQAVMMPYTYTSQISVEDAAEQARRMGVTFGIAEIHSIVNSFMQTLYPFFGNSPADATEENLQARARGTLLMGLSNKFGNLVLSTGNKSELSVGYCTLYGDMVGGFAVLKDVYKTIVFELAKYRNSLSETPVIPERVITRPPSAELRPDQKDQDSLPAYDVLDAILYAYIEEDLGQADIIAKGFDKEVVEKVIRLVDRNEYKRRQGAIGPRITSRAFSRERRYPIVNGWTAND
Atome Classification :
(20 SA)
---------.........10........20........30........40........50........60----------...-.....----70.-..--.---.------.---..80........---------90.-------------.-.--------.....100.......110.......120.......130--------------.----------------.----------------...---..------------------..140--------------.........150-..-.-.-...160.......-170-........180.......190.......200.....-.--.210.......220.......230.-----------------.---.-.....240-----------------.------------------------......--250.------------------------------------..-------------------------------------------------...------------.--------..260.......270.......280.......290.......300..----------------------------------.-----.----------------------------------.-----..310......-----.320....-----...330.......340.......350..-----...-.--.-----360.......370.......380.......390.......400....-...410.......420.......430-....----.----.---..440.......450.......460..--------.-....470.......----480----......---------..490-------------.--------.----.----......500----.....-...510...---------....------520----....-..-.-..530....-...540------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------MK
S
F
K
V
A
L
A
QFSPHIGNIDS
N
T
Q
K
M
I
E
Q
A
N
Q
AKKQDA
D
L
I
I
F
PE
L
S
V
IGYPAE
D
L
L
LRPN
L
----------
N
K
R
-
M
Q
K
A
F
----
A
Q
L
-
S
E
--
V
---
K
------
D
---
I
V
M
V
F
GFVNQTE---------DGQ-------------R-Y--------NS
A
A
VMKD
G
Q
V
L
G
V
FNKHNLPNYGVF
D
E
K
R
Y
F
Q
KG
H
----------------
Q
----------------
H
----------------
L
V
F
---
E
Y
------------------
L
G
H
----------------
K
F
G
V
L
I
C
E
D
IWS-
I
N
-
T
-
V
-
K
Q
L
S
QLNV
D
T
V
L
V
-LN--SSPYEVGK
P
Q
H
R
K
Q
T
L
S
E
L
A
K
QLHL
N
T
V
Y
V
NQVGGQ-D--
D
L
I
FDGTSFVSNQNG
E
I
A
L
QAP-SF-----------------K---E-D
L
Y
I
A
EFD-----------------R------------------------D
T
K
L
Y
K
--
V
--
V
------------------------------------ES-------------------------------------------------AP
A
------------
L
--------
E
T
F
A
E
I
Y
Q
G
L
V
M
A
T
R
D
Y
V
E
RSGF
P
G
V
I
L
GLSGGIDS
A
L
T
L
A
I
A
VDAI----------------------------------
G
-----
A
----------------------------------
E
-----
R
V
Q
A
VMMPYTY-----T
S
Q
I
S
V
E
D
-----
A
A
E
Q
A
R
RMGV
T
F
G
I
A
E
I
H
S
I
V
N
S
F
M
Q
T
L
-----
Y
P
F-F--G-----NSPAD
A
T
E
E
N
L
Q
A
RAR
G
T
L
L
M
GLSNKFG
N
L
V
L
STGNKS
E
L
S
V
G
Y
C
T
L
-
Y
G
DMVG
G
F
A
V
L
K
D
V
Y
K
T
I
V
F
E
L
A
K
Y
--
R
N
SL----S----E---TPVI
P
E
R
VITRPPSAELRPDQKDQDSL--------
P
-
A
Y
D
V
L
D
A
I
L
Y
A
Y
I
E
----
E
D-----LGQA
D
I
---------
I
AK---------------G--------F----
D
----
K
E
V
V
E
K
V
I
-----
R
L
V
D
R
-
N
E
Y
K
R
R
QGA---------IGP
R
------
I
------
T
S
R
A
-FS-R-ERRYPIVNG-WTAND-------
28
HHSearch
91.52
100%
-113
- C1 -
-
5KHA
3
?
A:
[9-548]
----------
K
S
F
K
V
A
L
A
Q
F
S
P
H
I
G
N
I
D
S
N
T
Q
K
M
I
E
Q
A
N
Q
A
K
K
Q
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A
D
L
I
I
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P
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L
S
V
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Y
P
A
E
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L
L
L
R
P
N
L
----------
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K
R
-
M
Q
K
A
F
----
A
Q
L
-
S
E
--
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---
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------
D
---
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V
M
V
F
G
F
V
N
Q
T
E
---------
D
G
Q
-------------
R
-
Y
--------
N
S
A
A
V
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K
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N
K
H
N
L
P
N
Y
G
V
F
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E
K
R
Y
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Q
K
G
H
----------------
Q
----------------
H
----------------
L
V
F
---
E
Y
------------------
L
G
H
----------------
K
F
G
V
L
I
C
E
D
I
W
S
-
I
N
-
T
-
V
-
K
Q
L
S
Q
L
N
V
D
T
V
L
V
-
L
N
--
S
S
P
Y
E
V
G
K
P
Q
H
R
K
Q
T
L
S
E
L
A
K
Q
L
H
L
N
I
V
Y
V
N
Q
V
G
G
Q
-
D
--
D
L
I
F
D
G
T
S
F
V
S
N
Q
N
G
E
I
A
L
Q
A
P
-
S
F
-----------------
K
---
E
-
D
L
Y
I
A
E
F
D
-----------------
R
------------------------
D
T
K
L
Y
K
--
V
--
V
------------------------------------
E
S
-------------------------------------------------
A
P
A
------------
L
--------
E
T
F
A
E
I
Y
Q
G
L
V
M
A
T
R
D
Y
V
E
R
S
G
F
P
G
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I
L
G
L
S
G
G
I
D
S
A
L
T
L
A
I
A
V
D
A
I
----------------------------------
G
-----
A
----------------------------------
E
-----
R
V
Q
A
V
M
M
P
Y
T
Y
-----
T
S
Q
I
S
V
E
D
-----
A
A
E
Q
A
R
R
M
G
V
T
F
G
I
A
E
I
H
S
I
V
N
S
F
M
Q
T
L
-----
Y
P
F
-
F
--
G
-----
N
S
P
A
D
A
T
E
E
N
L
Q
A
R
A
R
G
T
L
L
M
G
L
S
N
K
F
G
N
L
V
L
S
T
G
N
K
S
E
L
S
V
G
Y
C
T
L
-
Y
G
D
M
V
G
G
F
A
V
L
K
D
V
Y
K
T
I
V
F
E
L
A
K
Y
--
R
N
S
L
----
S
----
E
---
T
P
V
I
P
E
R
V
I
T
R
--------------
S
L
--------
P
-
A
Y
D
V
L
D
A
I
L
Y
A
Y
I
E
----
E
D
-----
L
G
Q
A
D
I
---------
I
A
K
---------------
G
--------
F
----
D
----
K
E
V
V
E
K
V
I
-----
R
L
V
D
R
-
N
E
Y
K
R
R
Q
G
A
---------
I
G
P
R
------
I
------
T
S
R
A
-
F
S
-
R
-
E
R
R
Y
P
I
V
N
G
-
W
T
A
N
D
-------
1
PsiBlast_PDB
91.32
99%
-113
- C1 -
-
5KHA
3
?
A:
[9-548]
----------
K
S
F
K
V
A
L
A
Q
F
S
P
H
I
G
N
I
D
S
N
T
Q
K
M
I
E
Q
A
N
Q
A
K
K
Q
D
A
D
L
I
I
F
P
E
L
S
V
I
G
Y
P
A
E
D
L
L
L
R
P
N
L
----------
N
K
R
-
M
Q
K
A
F
----
A
Q
L
-
S
E
--
V
---
K
------
D
---
I
V
M
V
F
G
F
V
N
Q
T
E
---------
D
G
Q
-------------
R
-
Y
--------
N
S
A
A
V
M
K
D
G
Q
V
L
G
V
F
N
K
H
N
L
P
N
Y
G
V
F
D
E
K
R
Y
F
Q
K
G
H
----------------
Q
----------------
H
----------------
L
V
F
---
E
Y
------------------
L
G
H
----------------
K
F
G
V
L
I
C
E
D
I
W
S
-
I
N
-
T
-
V
-
K
Q
L
S
Q
L
N
V
D
T
V
L
V
-
L
N
--
S
S
P
Y
E
V
G
K
P
Q
H
R
K
Q
T
L
S
E
L
A
K
Q
L
H
L
N
I
V
Y
V
N
Q
V
G
G
Q
-
D
--
D
L
I
F
D
G
T
S
F
V
S
N
Q
N
G
E
I
A
L
Q
A
P
-
S
F
-----------------
K
---
E
-
D
L
Y
I
A
E
F
D
-----------------
R
------------------------
D
T
K
L
Y
K
--
V
--
V
------------------------------------
E
S
-------------------------------------------------
A
P
A
------------
L
--------
E
T
F
A
E
I
Y
Q
G
L
V
M
A
T
R
D
Y
V
E
R
S
G
F
P
G
V
I
L
G
L
S
G
G
I
D
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A
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T
L
A
I
A
V
D
A
I
----------------------------------
G
-----
A
----------------------------------
E
-----
R
V
Q
A
V
M
M
P
Y
T
Y
-----
T
S
Q
I
S
V
E
D
-----
A
A
E
Q
A
R
R
M
G
V
T
F
G
I
A
E
I
H
S
I
V
N
S
F
M
Q
T
L
-----
Y
P
F
-
F
--
G
-----
N
S
P
A
D
A
T
E
E
N
L
Q
A
R
A
R
G
T
L
L
M
G
L
S
N
K
F
G
N
L
V
L
S
T
G
N
K
S
E
L
S
V
G
Y
C
T
L
-
Y
G
D
M
V
G
G
F
A
V
L
K
D
V
Y
K
T
I
V
F
E
L
A
K
Y
--
R
N
S
L
----
S
----
E
---
T
P
V
I
P
E
R
V
I
T
R
--------------
S
L
--------
P
-
A
Y
D
V
L
D
A
I
L
Y
A
Y
I
E
----
E
D
-----
L
G
Q
A
D
I
---------
I
A
K
---------------
G
--------
F
----
D
----
K
E
V
V
E
K
V
I
-----
R
L
V
D
R
-
N
E
Y
K
R
R
Q
G
A
---------
I
G
P
R
------
I
------
T
S
R
A
-
F
S
-
R
-
E
R
R
Y
P
I
V
N
G
-
W
T
A
N
D
-------
21
PsiBlast_CBE
91.07
99%
-112
- C1 -
-
5KHA
3
?
B:
[8-548]
---------
M
K
S
F
K
V
A
L
A
Q
F
S
P
H
I
G
N
I
D
S
N
T
Q
K
M
I
E
Q
A
N
Q
A
K
K
Q
D
A
D
L
I
I
F
P
E
L
S
V
I
G
Y
P
A
E
D
L
L
L
R
P
N
L
----------
N
K
R
-
M
Q
K
A
F
----
A
Q
L
-
S
E
--
V
---
K
------
D
---
I
V
M
V
F
G
F
V
N
Q
T
E
---------
D
G
Q
-------------
R
-
Y
--------
N
S
A
A
V
M
K
D
G
Q
V
L
G
V
F
N
K
H
N
L
P
N
Y
G
V
F
D
E
K
R
Y
F
Q
K
G
H
----------------
Q
----------------
H
----------------
L
V
F
---
E
Y
------------------
L
G
H
----------------
K
F
G
V
L
I
C
E
D
I
W
S
-
I
N
-
T
-
V
-
K
Q
L
S
Q
L
N
V
D
T
V
L
V
-
L
N
--
S
S
P
Y
E
V
G
K
P
Q
H
R
K
Q
T
L
S
E
L
A
K
Q
L
H
L
N
I
V
Y
V
N
Q
V
G
G
Q
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D
--
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F
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S
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A
P
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S
F
-----------------
K
---
E
-
D
L
Y
I
A
E
F
D
-----------------
R
------------------------
D
T
K
L
Y
K
--
V
--
V
------------------------------------
E
S
-------------------------------------------------
A
P
A
------------
L
--------
E
T
F
A
E
I
Y
Q
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L
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M
A
T
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D
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V
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S
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A
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A
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D
A
I
----------------------------------
G
-----
A
----------------------------------
E
-----
R
V
Q
A
V
M
M
P
Y
T
Y
-----
T
S
Q
I
S
V
E
D
-----
A
A
E
Q
A
R
R
M
G
V
T
F
G
I
A
E
I
H
S
I
V
N
S
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M
Q
T
L
-----
Y
P
F
-
F
--
G
------
S
P
A
D
A
T
E
E
N
L
Q
A
R
A
R
G
T
L
L
M
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L
S
N
K
F
G
N
L
V
L
S
T
G
N
K
S
E
L
S
V
G
Y
C
T
L
-
Y
G
D
M
V
G
G
F
A
V
L
K
D
V
Y
K
T
I
V
F
E
L
A
K
Y
--
R
N
S
L
----
S
----
E
---
T
P
V
I
P
E
R
V
I
T
R
--------------
S
L
--------
P
-
A
Y
D
V
L
D
A
I
L
Y
A
Y
I
E
----
E
D
-----
L
G
Q
A
D
I
---------
I
A
K
---------------
G
--------
F
----
D
----
K
E
V
V
E
K
V
I
-----
R
L
V
D
R
-
N
E
Y
K
R
R
Q
G
A
---------
I
G
P
R
------
I
------
T
S
R
A
-
F
S
-
R
-
E
R
R
Y
P
I
V
N
G
-
W
T
A
N
D
-------
3
PsiBlast_PDB
65.14
40%
10
- C1 -
-
3N05
-
?
A:
[5-581]
------------
L
R
L
A
L
N
Q
I
D
S
T
V
G
D
I
A
G
N
A
E
A
I
L
R
W
T
R
H
S
A
E
Q
G
A
H
L
V
A
F
P
E
M
A
L
T
G
Y
P
V
E
D
L
A
L
R
S
S
F
----------
V
E
A
-
S
R
T
A
L
R
E
L
A
A
R
L
-
A
E
E
G
F
---
G
------
E
---
L
P
V
L
V
G
Y
L
D
R
S
E
---------
S
A
Q
P------------
K
-
Y
GQPAGAPR
N
A
A
A
V
L
H
R
G
R
V
A
L
T
F
A
K
H
H
L
P
N
Y
G
V
F
D
E
F
R
Y
F
V
P
G
D
----------------
T
----------------
M
----------------
P
I
V
---
R
L
------------------
H
G
V
----------------
D
I
A
L
A
I
C
E
D
L
W
Q
-
D
G
G
R
-
V
-
P
A
A
R
S
A
G
A
G
L
L
L
S
-
V
N
--
A
S
P
Y
E
R
D
K
D
D
T
R
L
E
L
V
R
K
R
A
Q
E
A
G
C
T
T
A
Y
L
A
M
I
G
G
Q
-
D
--
E
L
V
F
D
G
D
S
I
V
V
D
R
D
G
E
V
V
A
R
A
P
-
Q
F
-----------------
S
---
E
-
G
C
V
V
L
D
L
D
L
P
A
A
EAE
P
P
T
G
V
VDDGL
R
------------------------
I
D
R
L
V
I
--
S
--
E
------------------------------------
E
P
-------------------------------------------------
L
P
A
YEAELAGGY
A
D
R
L
--------
D
A
D
E
E
V
Y
S
A
L
V
V
G
L
R
A
Y
V
A
K
N
G
F
R
S
V
L
I
G
L
S
G
G
I
D
S
A
L
V
A
A
I
A
C
D
A
L
----------------------------------
G
-----
A
----------------------------------
Q
-----
N
V
Y
G
V
S
M
P
S
K
Y
-----
S
S
D
H
S
K
G
D
-----
A
A
E
L
A
R
R
T
G
L
N
F
R
T
V
S
I
E
P
M
F
D
A
Y
M
A
S
L
-------------------
G
L
T
G
L
A
E
E
N
L
Q
S
R
L
R
G
T
T
L
M
A
I
S
N
Q
E
G
H
I
V
L
A
P
G
N
K
S
E
L
A
V
G
Y
S
T
L
-
Y
G
D
S
V
G
A
Y
G
P
I
K
D
V
Y
K
T
S
I
F
R
L
A
E
W
--
R
N
R
A
----
A
A
E
R
G
Q
---
T
P
P
I
P
E
A
S
I
T
K
P
-------------------------
D
Y
P
V
L
D
A
I
L
E
L
Y
V
D
----
R
D
-----
T
G
A
D
A
I
---------
V
A
A
---------------
G
--------
Y
----
D
----
R
E
L
V
V
K
T
L
-----
R
M
V
D
T
-
A
E
Y
K
R
R
Q
Y
P
---------
P
G
T
K
------
I
------
S
A
K
G
-
F
G
-
K
-
D
R
R
L
P
I
T
N
R
-
W
-----------
31
HHSearch
62.56
43%
12
- C1 -
-
3N05
-
?
A:
[2-583]
---------
S
L
Q
L
R
L
A
L
N
Q
I
D
S
T
V
G
D
I
A
G
N
A
E
A
I
L
R
W
T
R
H
S
A
E
Q
G
A
H
L
V
A
F
P
E
M
A
L
T
G
Y
P
V
E
D
L
A
L
R
S
S
F
----------
V
E
A
-
S
R
T
A
L
----
R
E
L
-
A
A
--
R
---
L
A
E
E
GFG
E
---
L
P
V
L
V
G
Y
L
D
R
S
E
SAQPKYGQP
A
G
A
-------------
P
-
R
--------
N
A
A
A
V
L
H
R
G
R
V
A
L
T
F
A
K
H
H
L
P
N
Y
G
V
F
D
E
F
R
Y
F
V
P
G
D
----------------
T
----------------
M
----------------
P
I
V
---
R
L
------------------
H
G
V
----------------
D
I
A
L
A
I
C
E
D
L
W
Q
-
D
G
-
G
R
V
-
P
A
A
R
S
A
G
A
G
L
L
L
S
-
V
N
--
A
S
P
Y
E
R
D
K
D
D
T
R
L
E
L
V
R
K
R
A
Q
E
A
G
C
T
T
A
Y
L
A
M
I
G
G
Q
-
D
--
E
L
V
F
D
G
D
S
I
V
V
D
R
D
G
E
V
V
A
R
A
P
-
Q
F
-----------------
S
---
E
-
G
C
V
V
L
D
L
D
-----------------
L
------------------------
P
A
A
E
A
E
--
P
--
P
T
G
V
VDDGL
R
I
D
R
L
V
ISEEPLPAYEAELAG-------
G
Y
-------------------------------------------------
A
D
R
------------
L
--------
D
A
D
E
E
V
Y
S
A
L
V
V
G
L
R
A
Y
V
A
K
N
G
F
R
S
V
L
I
G
L
S
G
G
I
D
S
A
L
V
A
A
I
A
C
D
A
L
----------------------------------
G
-----
A
----------------------------------
Q
-----
N
V
Y
G
V
S
M
P
S
K
Y
-----
S
S
D
H
S
K
G
D
-----
A
A
E
L
A
R
R
T
G
L
N
F
R
T
V
S
I
E
P
M
F
D
A
Y
M
A
S
L
-----
G
-------------
L
-
T
G
L
A
E
E
N
L
Q
S
R
L
R
G
T
T
L
M
A
I
S
N
Q
E
G
H
I
V
L
A
P
G
N
K
S
E
L
A
V
G
Y
S
T
L
-
Y
G
D
S
V
G
A
Y
G
P
I
K
D
V
Y
K
T
S
I
F
R
L
A
E
W
--
R
N
R
A
----
A
A
E
R
G
Q
---
T
P
P
I
P
E
A
S
I
T
K
P
-------------------------
D
Y
P
V
L
D
A
I
L
E
L
Y
V
D
----
R
D
-----
T
G
A
D
A
I
---------
V
A
A
---------------
G
--------
Y
----
D
----
R
E
L
V
V
K
T
L
-----
R
M
V
D
T
-
A
E
Y
K
R
R
Q
Y
P
---------
P
G
T
K
------
I
------
S
A
K
G
-
F
G
-
K
-
D
R
R
L
P
I
T
N
R
-
W
R
E
---------
2
PsiBlast_PDB
58.96
46%
7
- C1 -
-
4F4H
-
?
A:
[6-558]
----------
K
T
-
R
I
A
L
A
Q
L
N
V
T
V
G
D
F
A
G
N
V
A
K
I
V
A
A
A
Q
A
A
H
D
A
G
A
H
F
L
I
A
P
E
L
A
L
S
G
Y
P
P
E
D
L
L
L
R
P
A
F
Y
A
A
S
D
A
A
L
A
E
L
A
A
-
Q
L
K
P
F
----
A
G
L
-
A
------------------
V
L
V
G
H
P
L
R
A
P
--------------ANRAIERGVPPVD
T
-
Y
--------
N
A
A
S
L
I
V
G
G
E
V
A
G
T
Y
R
K
Q
D
L
P
N
T
E
V
F
D
E
K
R
Y
F
A
T
D
A
----------------
A
----------------
P
----------------
Y
V
F
---
E
L
------------------
N
G
V
----------------
K
F
G
V
V
I
C
E
D
V
W
H
-
A
S
-
A
-
A
-
Q
L
A
K
A
A
G
A
Q
V
L
I
V
-
P
N
--
G
S
P
Y
H
M
N
K
D
A
V
R
I
D
I
L
R
A
R
I
R
E
T
G
L
P
M
V
Y
V
N
L
V
G
G
Q
-
D
--
E
L
V
F
D
G
G
S
F
V
L
D
G
A
G
E
L
V
A
K
M
P
-
Q
F
-----------------
E
---
E
-
G
N
A
I
V
E
F
D
-----------------
G
------------------------
A
R
A
L
P
A
--
A
--
I
------------------------------------
A
P
-------------------------------------------------
A
L
S
------------
V
--------
E
--
A
Q
V
Y
R
A
L
V
L
G
V
R
D
Y
I
G
K
N
G
F
P
G
A
I
I
G
L
S
G
G
V
D
S
A
L
V
L
A
V
A
V
D
A
L
----------------------------------
G
-----
A
----------------------------------
E
-----
R
V
R
A
V
M
M
P
S
R
Y
-----
T
A
G
I
S
T
T
D
-----
A
A
D
M
A
R
R
V
G
V
R
Y
D
E
I
A
I
A
P
M
F
D
A
F
R
A
S
L
-----
A
A
E
-
F
--
A
-----
G
L
A
E
D
A
T
E
E
N
I
Q
A
R
I
R
G
T
L
L
M
A
L
S
N
K
F
G
S
I
V
L
T
T
G
N
K
S
E
M
A
V
G
Y
C
T
L
-
Y
G
D
M
A
G
G
F
A
V
I
K
D
I
A
K
T
L
V
Y
R
L
C
R
Y
--
R
N
A
A
----
A
----
E
YGQ
P
D
I
V
P
E
R
I
L
T
R
---------------
L
--------
P
-
P
Y
D
V
L
D
A
I
M
R
M
Y
M
E
----
E
D
-----
R
P
L
A
E
I
---------
V
A
A
---------------
G
--------
Y
----
S
----
E
A
D
V
K
R
V
T
-----
R
L
I
K
I
-
N
E
Y
K
R
R
Q
A
P
---------
V
G
I
R
------
V
------
T
H
R
A
-
F
G
-
R
-
D
W
R
Y
P
I
T
S
--------------
6
PsiBlast_PDB
55.24
26%
-23
- C1 -
-
3SYT
6
NADE_MYCTU
A:
[14-539]
-------------
R
V
A
A
C
T
H
H
T
T
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
----------
L
D
A
-
V
E
D
A
L
----
L
D
L
V
T
E
--
S
---
A
------
D
---
L
L
P
V
L
V
V
G
A
P
L
R
---------
H
R
H
-------------
R
I
Y
--------
N
T
A
V
V
I
H
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
----------------
G
----------------
E
R
G
T
I
R
I
GGADVAFGTD
L
L
F
A
A
S
D
L
------------------
P
G
F
----------------
V
L
H
V
E
I
C
E
D
M
F
V
-
P
M
-
P
-
P
-
S
A
E
A
A
L
A
G
A
T
V
L
A
N
L
S
--
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
-
S
TT
D
L
A
W
D
G
Q
T
M
I
W
-
E
N
G
A
L
L
A
E
S
E
-
R
F
PK
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
---
E
-
R
L
R
M
G
T
F
D
-----------------
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
LDPPAG
D
I
G
L
L
R
--
E
--
V
------------------------------------
E
R
-------------------------------------------------
F
P
F
------------
V
PAD
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
----------------------------------
D
-----
R
----------------------------------
E
GRPRS
D
I
L
A
F
A
L
P
G
F
-----------
K
N
N
-----
A
I
K
L
A
R
A
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G----
H
P
Y
S
V
--
G
-----
E
K
V
Y
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
--
V
I
S
A
----
G
----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
55.11
25%
-6
* C1 *
-
3SEQ
3
NADE_MYCTU
A:
[10-667]
---------
H
G
F
V
R
V
A
A
C
T
H
H
T
T
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
----------
L
D
A
-
V
E
D
A
L
----
L
D
L
-
V
T
--
E
S
A
D
L
------
L
---
P
V
L
V
V
G
A
P
L
R
H
----------
R
H
R
-------------
I
-
Y
--------
N
T
A
V
V
I
H
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
----------------
G
E
---------------
R
----------------
G
T
I
---
R
I
GGADVAFGTD
L
L
F
A
A
SDL
P
G
F
----------------
V
L
H
V
E
I
A
E
D
M
F
V
-
P
M
-
P
-
P
S
A
E
A
A
L
A
G
A
T
V
L
A
N
-
L
S
--
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
-
S
TT
D
L
A
W
D
G
Q
T
M
I
W
-
E
N
G
A
L
L
A
E
S
E
-
R
F
-----------------
P
K
G
-
V
-
R
R
S
V
A
D
V
D
-----------------
T
------------------------
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
ELTES
F
R
R
I
D
F
A
LDPPAGDIGLL
R
E
V
E
R
F
PFVPAD
P
------------------------------------------
Q
R
L
------------
Q
--------
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
----------------------------------
D
-----
R
----------------------------------
E
GRPRS
D
I
L
A
F
A
L
P
G
F
-----------
K
N
N
-----
A
I
K
L
A
R
A
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
-----
G
H
P
-
Y
SV
G
E----
K
V
-
Y
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
--
V
I
S
A
----
G
EFG
E
K
---
V
G
E
V
L
Q
S
V
L
D
T
E
I
T
--------
S
E
A
K
V
--------
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
----
Y
G
-----
F
R
P
S
K
I
---------
A
F
L
A
W
H
A
WNDAE
R
G
N
W
P
P
G
FPKSE
R
P
S
Y
S
L
A
E
I
----
R
H
W
L
Q
I
F
V
-----
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
---------
N
G
P
K
------
V
------
S
H
G
G
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
-
A
R
----------
11
PsiBlast_PDB
55.09
26%
-32
- C1 -
-
3SZG
4
NADE_MYCTU
A:
[14-540]
-------------
R
V
A
A
C
T
H
H
T
T
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
----------
L
D
A
-
V
E
D
A
L
----
L
D
L
V
T
E
--
S
---
A
------
D
---
L
L
P
V
L
V
V
G
A
P
L
R
---------
H
R
H
-------------
R
I
Y
--------
N
T
A
V
V
I
H
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
----------------
G
----------------
E
R
G
T
I
R
I
GGADVAFGTD
L
L
F
A
A
S
D
L
------------------
P
G
F
----------------
V
L
H
V
E
I
A
E
D
M
F
V
-
P
M
-
P
-
P
-
S
A
E
A
A
L
A
G
A
T
V
L
A
N
L
S
--
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
-
S
TT
D
L
A
W
D
G
Q
T
M
I
W
-
E
N
G
A
L
L
A
E
S
E
-
R
F
PK
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
---
E
-
R
L
R
M
G
T
F
D
-----------------
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
LDPPAG
D
I
G
L
L
R
--
E
--
V
------------------------------------
E
R
-------------------------------------------------
F
P
F
------------
V
PAD
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
----------------------------------
D
-----
R
----------------------------------
E
GRPRS
D
I
L
A
F
A
L
P
G
F
-----------
K
N
N
-----
A
I
K
L
A
R
A
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G----
H
----------------
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
--
V
I
S
A
----
G
----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
54.29
26%
-18
- C1 -
-
3SEQ
3
NADE_MYCTU
A:
[14-539]
-------------
R
V
A
A
C
T
H
H
T
T
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
----------
L
D
A
-
V
E
D
A
L
----
L
D
L
V
T
E
--
S
---
A
------
D
---
L
L
P
V
L
V
V
G
A
P
L
R
---------
H
R
H
-------------
R
I
Y
--------
N
T
A
V
V
I
H
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
----------------
G
----------------
E
R
G
T
I
R
I
GGADVAFGTD
L
L
F
A
A
S
D
L
------------------
P
G
F
----------------
V
L
H
V
E
I
A
E
D
M
F
V
-
P
M
-
P
-
P
-
S
A
E
A
A
L
A
G
A
T
V
L
A
N
L
S
--
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
-
S
TT
D
L
A
W
D
G
Q
T
M
I
W
-
E
N
G
A
L
L
A
E
S
E
-
R
F
PK
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
---
E
-
R
L
R
M
G
T
F
D
-----------------
D
N
R
R
H
H
R
ELTES
F
R
R
I
D
F
A
LDPPAG
D
I
G
L
L
R
--
E
--
V
------------------------------------
E
R
-------------------------------------------------
F
P
F
------------
V
PAD
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
----------------------------------
D
-----
R
----------------------------------
E
GRPRS
D
I
L
A
F
A
L
P
G
F
-----------
K
N
N
-----
A
I
K
L
A
R
A
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G----
H
P
Y
S
V
--
G
-----
E
K
V
Y
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
--
V
I
S
A
----
G
----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
54.07
26%
-19
- C1 -
-
3SEZ
3
NADE_MYCTU
A:
[14-541]
-------------
R
V
A
A
C
T
H
H
T
T
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
----------
L
D
A
-
V
E
D
A
L
----
L
D
L
V
T
E
--
S
---
A
------
D
---
L
L
P
V
L
V
V
G
A
P
L
R
---------
H
R
H
-------------
R
I
Y
--------
N
T
A
V
V
I
H
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
----------------
G
----------------
E
R
G
T
I
R
I
GGADVAFGTD
L
L
F
A
A
S
D
L
------------------
P
G
F
----------------
V
L
H
V
E
I
A
E
D
M
F
V
-
P
M
-
P
-
P
-
S
A
E
A
A
L
A
G
A
T
V
L
A
N
L
S
--
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
-
S
TT
D
L
A
W
D
G
Q
T
M
I
W
-
E
N
G
A
L
L
A
E
S
E
-
R
F
PK
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
---
E
-
R
L
R
M
G
T
F
D
-----------------
D
N
R
R
H
H
R
ELTES
F
R
R
I
D
F
A
LDPPAG
D
I
G
L
L
R
--
E
--
V
------------------------------------
E
R
-------------------------------------------------
F
P
F
------------
V
PAD
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
----------------------------------
D
-----
R
----------------------------------
E
GRPRS
D
I
L
A
F
A
L
P
G
F
-----------
K
N
N
-----
A
I
K
L
A
R
A
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G----
H
P
Y
S
V
--
G
-----
E
K
V
Y
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
--
V
I
S
A
----
G
----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.84
26%
-22
- C1 -
-
3DLA
7
NADE_MYCTU
A:
[14-541]
-------------
R
V
A
A
C
T
H
H
T
T
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
----------
L
D
A
-
V
E
D
A
L
----
L
D
L
V
T
E
--
S
---
A
------
D
---
L
L
P
V
L
V
V
G
A
P
L
R
---------
H
R
H
-------------
R
I
Y
--------
N
T
A
V
V
I
H
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
----------------
G
----------------
E
R
G
T
I
R
I
GGADVAFGTD
L
L
F
A
A
S
D
L
------------------
P
G
F
----------------
V
L
H
V
E
I
C
E
D
M
F
V
-
P
M
-
P
-
P
-
S
A
E
A
A
L
A
G
A
T
V
L
A
N
L
S
--
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
-
S
TT
D
L
A
W
D
G
Q
T
M
I
W
-
E
N
G
A
L
L
A
E
S
E
-
R
F
PK
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
---
E
-
R
L
R
M
G
T
F
D
-----------------
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
LDPPAG
D
I
G
L
L
R
--
E
--
V
------------------------------------
E
R
-------------------------------------------------
F
P
F
------------
V
PAD
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
----------------------------------
D
-----
R
----------------------------------
E
GRPRS
D
I
L
A
F
A
L
P
G
----------
H
T
K
N
N
-----
A
I
K
L
A
R
A
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G----
H
----------------
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
--
V
I
S
A
----
G
----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
52.18
25%
-14
- C1 -
-
3ILV
-
?
A:
[2-617]
----------
S
T
I
R
I
G
G
A
A
V
N
Q
T
P
I
D
W
E
N
N
V
K
N
I
L
D
A
I
E
E
A
K
N
A
N
V
E
I
L
C
L
P
E
L
C
I
T
G
Y
G
C
E
D
L
F
L
T
D
W
V
----------
A
E
T
-
A
I
E
Y
C
----
F
E
I
-
A
A
--
S
C--
T
------
D
---
I
T
V
S
L
G
L
P
M
R
I
----------
A
G
I
-------------
T
-
Y
--------
N
C
V
C
L
V
E
N
G
I
V
K
G
F
S
A
K
Q
F
L
A
N
E
G
V
H
Y
E
T
R
W
F
T
A
W
P
----------------
R
N
H
T
T
T
F
L
Y
ND
V
K
Y
P
F
G
D
----------------
V
L
Y
---
N
V
------------------
K
D
A
----------------
R
I
G
F
E
I
C
E
D
-------------
H
Y
E
K
G
A
T
L
V
L
N
-
P
S
--
A
S
H
F
A
F
G
K
S
A
I
R
Y
D
L
V
I
G
G
S
E
R
F
D
C
T
Y
V
Y
A
N
L
L
G
N
E
-
A
G-
R
M
I
Y
D
G
E
V
-
L
I
A
H
K
G
K
L
I
Q
R
N
D
-
R
L
-----------------
S
FKN
V
-
N
L
I
Y
A
D
I
A
-----------------
T
------------------------------------------------------------------------------------------------------------------------------------------
L
--------
E
K
E
F
E
F
W
E
A
T
S
L
G
L
F
D
Y
M
R
K
S
R
S
K
G
F
V
L
S
L
S
G
G
A
D
S
S
A
C
A
I
M
V
A
E
M
I
----------------------------------
R
-----
K
G
L
K
E
L
G
L
T
A
F
L
Q
K
S
NMETLFDLPALQHLPF
E
E
Q
A
K
-----
K
I
T
A
V
F
L
T
T
A
Y
Q
S
T
RN
S
G
D
E
T
Y
T
S
-----
A
K
T
L
A
E
S
I
G
A
T
F
Y
N
W
S
V
D
E
E
I
E
Q
Y
K
A
T
I
-----
E
N
V
-
I
--
E
R
P
L
T
W
E
K
-
D
D
I
T
L
Q
N
I
Q
A
R
G
R
A
P
I
I
W
M
L
T
N
V
K
Q
A
L
L
I
T
T
S
N
R
S
E
G
D
V
G
Y
A
T
M
-
D
G
D
T
A
G
G
I
A
P
I
A
G
V
D
K
D
F
I
R
S
W
L
R
W
--
A
E
K
N
-------------
R
N
Q
H
G
L
H
I
V
N
---------------
D
L
--------
M
-
P
Y
D
V
L
A
R
I
E
R
K
A
I
K
----
E
R
-----
L
S
P
V
Q
V
---------
Y
T
A
---------------
L
L
T
E
GP---
Y
----
T
K
N
E
F
K
Y
W
V
K
K
F
F
-----
R
L
W
S
I
-
N
Q
W
K
R
E
R
L
A
---------
P
S
F
H
------
M
------
D
D
F
N
-
I
D
P
R
S
W
Y
R
F
P
I
L
S
S
G
F
A
K
---------
7
PsiBlast_PDB
51.84
24%
-6
- C1 -
-
3ILV
-
?
A:
[17-618]
-------------------------
D
W
E
N
N
V
K
N
I
L
D
A
I
E
E
A
K
N
A
N
V
E
I
L
C
L
P
E
L
C
I
T
G
Y
G
C
E
D
L
F
L
T
D
W
V
----------
A
E
T
A
I
E
Y
C
F
----
E
I
A
-
A
S
--
C
---
T
------
D
---
I
T
V
S
L
G
L
P
M
R
I
A
----------
G
I
-------------
T
-
Y
--------
N
C
V
C
L
V
E
N
G
I
V
K
G
F
S
A
K
Q
F
L
A
N
E
G
V
H
Y
E
T
R
W
F
T
A
W
P
----------------
R
----------------
N
----------------
H
T
T
---
T
F
------------------
L
Y
N
D
V
K
Y
P
F
G
D
V
L
Y
N
V
KD
A
R
I
G
F
E
I
C
E
D
---------------
H
Y
E
K
G
A
T
L
V
-
L
N
P
S
A
S
H
F
A
F
G
K
S
A
I
R
Y
D
L
V
I
G
G
S
E
R
F
D
C
T
Y
V
Y
A
N
L
L
G
N
E
A
G
--
R
M
I
Y
D
G
E
V
L
I
A
H
K
G
K
L
I
Q
R
N
D
R
L
S
F
-----------------
K
---
N
V
N
L
I
Y
A
D
I
A
-----------------
T
------------------------------------------------------------------------------------------------------------------------------------------
L
--------
E
K
E
F
E
F
W
E
A
T
S
L
G
L
F
D
Y
M
R
K
S
R
S
K
G
F
V
L
S
L
S
G
G
A
D
S
S
A
C
A
I
M
V
A
E
M
I
R
K
G
L
K
E
L
G
L
T
A
F
L
Q
K
S
NMETLFDLPALQHLPF
E
E
Q
-----
A
----------------------------------
K
-----
K
I
T
A
V
F
L
T
T
A
Y
-----
Q
S
T
R
N
S
G
D
E
T
Y
T
S
A
K
T
L
A
E
S
I
G
A
T
F
Y
N
W
S
V
D
E
E
I
E
Q
Y
K
A
T
I
E
N
V
I
E
R
P
L
-
T
--
W
-----
E
K
D
-
D
I
T
L
Q
N
I
Q
A
R
G
R
A
P
I
I
W
M
L
T
N
V
K
Q
A
L
L
I
T
T
S
N
R
S
E
G
D
V
G
Y
A
T
M
-
D
G
D
T
A
G
G
I
A
P
I
A
G
V
D
K
D
F
I
R
S
W
L
R
W
A
E
K
N
R
N
----
Q
----
H
---
G
L
H
I
V
N
-------------------
D
L
--------
M
-
P
Y
D
V
L
A
R
I
E
R
K
A
I
K
----
E
R
-----
L
S
P
V
Q
V
Y
T
A
L
L
T
E
GP
Y
T
K
---------------
N
--------
E
----
F
----
K
Y
W
V
K
K
F
F
-----
R
L
W
S
I
-
N
Q
W
K
R
E
R
L
A
P
S
F
H
M
D
DFN
I
D
P
R
SW
Y
R
F
P
I
------
L
S
S
G
-
F
A
-
K
-
E
---------------------
51
Fugue
50.96
25%
12
- C1 -
-
3DLA
7
NADE_MYCTU
A:
[1-680]
SMNFYSAYQ
H
G
F
V
R
V
A
A
C
T
H
H
T
T
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
----------
L
D
A
-
V
E
D
A
L
----
L
D
L
-
V
T
--
E
---
S
------
A
DLL
P
V
L
V
V
G
A
P
L
R
H
----------
R
H
R
-------------
I
-
Y
--------
N
T
A
V
V
I
H
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
G
E
R
G
T
I
R
I
GGADVAFG
T
----------------
D
----------------
L
L
F
---
A
A
------------------
S
D
L
PG
F
-------------
V
L
H
V
E
I
C
E
D
M
F
V
P
M
P
-
P
-
S
-
A
E
A
A
L
A
G
A
T
V
L
A
N
-
L
S
--
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
-
S
TT
D
L
A
W
D
G
Q
T
M
I
W
E
-
N
G
A
L
L
A
E
S
E
-
R
F
-----------------
P
---
K
-
G
V
R
R
S
V
A
D
-----------------
V
------------------------
D
T
E
L
L
R
--
S
--
E
------------------------------------
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
LDPPAGDIGLL
R
E
V
E
RFPFVPAD
P
Q
R
L
------------
Q
--------
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
----------------------------------
D
R
E
GRP
R
----------------------------------
S
-----
D
I
L
A
F
A
L
P
G
H
----------
T
K
N
N
-----
A
I
K
L
A
R
A
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
--------------------
G
H
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
--
V
I
S
A
GEFG
E
----
K
---
V
G
E
V
L
Q
S
V
L
D
T
E
I
T
A
K
V
G
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
YGF
R
-
P
S
K
I
A
F
L
A
W
H
A
W
N
D
----
A
E
R
G
N
W
P
P
G
F
P
K
S
---------
E
R
P
---------------
S
--------
Y
----
S
----
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
-
S
Q
F
K
R
S
A
L
P
---------
N
G
P
K
------
V
S
HG
G
A
L
S
P
R
G
-
D
W
-
R
-
A
P
S
D
M
S
A
R
I
-
W
L
D
Q
I
D
R
EVPKG
8
PsiBlast_PDB
49.58
26%
-
- C1 -
-
3SDB
-
NADE_MYCTU
A:
[13-538]
-------------
R
V
A
A
C
T
H
H
T
T
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
----------
L
D
A
-
V
E
D
A
L
----
L
D
L
V
T
E
--
S
---
A
------
D
---
L
L
P
V
L
V
V
G
A
P
L
R
---------
H
R
H
-------------
R
I
Y
--------
N
T
A
V
V
I
H
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
----------------
G
----------------
E
R
G
T
I
R
I
GGADVAFGTD
L
L
F
A
AS
D
L
------------------
P
G
F
----------------
V
L
H
V
E
I
A
E
D
M
F
V
-
P
M
-
P
-
P
-
S
A
E
A
A
L
A
G
A
T
V
L
A
N
L
S
--
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
-
S
TT
D
L
A
W
D
G
Q
T
M
I
W
-
E
N
G
A
L
L
A
E
S
E
-
R
F
PK
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
---
E
-
R
L
R
M
G
T
F
D
-----------------
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
LDPPAG
D
I
G
L
L
R
--
E
--
V
------------------------------------
E
R
-------------------------------------------------
F
P
F
------------
V
PAD
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
----------------------------------
D
-----
R
----------------------------------
E
GRPRS
D
I
L
A
F
A
L
P
G
-------------
N
N
-----
A
I
K
L
A
R
A
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
-----------------------
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
--
V
I
S
A
----
G
----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
49.05
35%
-78
- C1 -
-
2E18
1
NADE_PYRHO
B:
[11-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
L
E
F
I
R
E
K
G
N
N
G
V
V
I
G
I
S
G
G
V
D
S
A
T
V
A
Y
L
A
T
K
A
L
----------------------------------
G
-----
K
----------------------------------
E
-----
K
V
L
G
L
I
M
P
Y
F
E
-------
N
K
D
V
E
D
-----
A
K
L
V
A
E
K
L
G
I
G
Y
K
V
I
N
I
K
P
I
V
D
S
F
V
E
N
L
-----
E
L
N
-----------
L
-
D
R
K
G
L
G
N
I
M
S
R
T
R
M
I
M
L
Y
A
H
A
N
S
L
G
R
I
V
L
G
T
S
N
R
S
E
F
L
T
G
Y
F
T
K
-
W
G
D
G
A
S
D
Y
A
P
I
I
N
L
Y
K
T
E
V
W
E
I
A
K
R
--
I
G
------------------
V
P
E
R
I
V
K
K
K
P
S
A
G
L
W
E
G
Q
T
D
E
D
E
L
--------
G
I
S
Y
N
L
L
D
E
I
L
W
R
M
I
D
----
L
K
-----
I
G
K
E
E
I
---------
A
K
D
L--------------
G
--------
I
----
P
----
L
S
L
V
E
R
V
E
-----
E
L
I
K
K
-
S
E
H
K
R
R
L
-
P
---------
I
G
P
S
------
F
------
E
D
L
I
-
V
G
-------------------------
32
HHSearch
48.97
25%
-
- C1 -
-
3SDB
-
NADE_MYCTU
A:
[9-666]
---------
H
G
F
V
R
V
A
A
C
T
H
H
T
T
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
----------
L
D
A
-
V
E
D
A
L
----
L
D
L
-
V
T
--
E
S
A
D
L
------
L
---
P
V
L
V
V
G
A
P
L
R
H
----------
R
H
R
-------------
I
-
Y
--------
N
T
A
V
V
I
H
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
----------------
G
E
---------------
R
----------------
G
T
I
---
R
I
GGADVAFGTD
L
L
F
A
ASDL
P
G
F
----------------
V
L
H
V
E
I
A
E
D
M
F
V
-
P
M
-
P
-
P
S
A
E
A
A
L
A
G
A
T
V
L
A
N
-
L
S
--
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
-
S
TT
D
L
A
W
D
G
Q
T
M
I
W
-
E
N
G
A
L
L
A
E
S
E
-
R
F
-----------------
P
K
G
-
V
-
R
R
S
V
A
D
V
D
-----------------
T
------------------------
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
LDPPAGDIGLL
R
E
V
E
R
F
PFVPAD
P
------------------------------------------
Q
R
L
------------
Q
--------
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
----------------------------------
D
-----
R
----------------------------------
E
GRPRS
D
I
L
A
F
A
L
P
G
-------------
N
N
-----
A
I
K
L
A
R
A
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
-----------------------
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
--
V
I
S
A
----
G
EFG
E
K
---
V
G
E
V
L
Q
S
V
L
D
T
E
I
T
--------
S
E
A
K
V
--------
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
----
Y
G
-----
F
R
P
S
K
I
---------
A
F
L
A
W
H
A
W
NDAE
R
G
N
W
P
P
G
FPKSE
R
P
S
Y
S
L
A
E
I
----
R
H
W
L
Q
I
F
V
-----
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
---------
N
G
P
K
------
V
------
S
H
G
G
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
-
A
R
----------
34
HHSearch
47.53
26%
-84
- C1 -
-
1XNG
3
NADE_HELPY
B:
[4-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Q
K
L
I
V
Y
L
C
D
F
L
E
K
E
V
Q
K
R
G
F
K
K
V
V
Y
G
L
S
G
G
L
D
S
A
V
V
G
V
L
C
Q
K
V
F
----------------------------------
K
----------------------------------------
E
-----
N
A
H
A
L
L
M
P
S
S
V
-----
S
M
P
E
N
K
T
D
-----
A
L
N
L
C
E
K
F
S
I
P
Y
T
E
Y
S
I
A
P
Y
D
A
I
F
S
S
H
F
-----
K
D
------------
A
-
S
L
T
R
K
G
N
F
C
A
R
L
R
M
A
F
L
Y
D
Y
S
L
K
S
D
S
L
V
I
G
T
S
N
K
S
E
R
M
L
G
Y
G
T
L
-
F
G
D
L
A
C
A
I
N
P
I
G
E
L
F
K
T
E
V
Y
E
L
A
R
R
--
L
N
------------------
I
P
K
K
I
L
N
K
P
P
S
A
D
L
F
V
G
Q
S
D
E
K
D
L
--------
G
Y
P
Y
S
V
I
D
P
L
L
K
D
I
E
A
LFQT
K
P
-----
I
D
T
E
T
L
---------
A
Q
L
---------------
G
--------
Y
----
D
----
E
I
L
V
K
N
I
T
-----
S
R
I
Q
K
-
N
A
F
K
L
E
-
L
P
---------
A
I
A
K
------
R
------
F
N
P
E
-
L
E
-------------------------
23
PsiBlast_CBE
46.81
33%
-83
- C1 -
-
2E18
1
NADE_PYRHO
B:
[6-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
V
I
E
R
I
L
E
F
I
R
E
K
G
N
N
G
V
V
I
G
I
S
G
G
V
D
S
A
T
V
A
Y
L
A
T
K
A
L
----------------------------------
G
-----
K
----------------------------------
E
-----
K
V
L
G
L
I
M
P
Y
F
E
-----
N
K
D
--
V
E
D
-----
A
K
L
V
A
E
K
L
G
I
G
Y
K
V
I
N
I
K
P
I
V
D
S
F
V
E
N
L
-----
E
L
N
-
L
--
D
-----
R
K
G
L
G
----
N
I
M
S
R
T
R
M
I
M
L
Y
A
H
A
N
S
L
G
R
I
V
L
G
T
S
N
R
S
E
F
L
T
G
Y
F
T
K
-
W
G
D
G
A
S
D
Y
A
P
I
I
N
L
Y
K
T
E
V
W
E
I
A
K
R
--
I
G
------------------
V
P
E
R
I
V
K
K
K
P
S
A
G
L
W
E
G
Q
T
D
E
D
E
L
--------
G
I
S
Y
N
L
L
D
E
I
L
W
R
M
I
D
----
L
K
-----
I
G
K
E
E
I
---------
A
K
D
L--------------
G
--------
I
----
P
----
L
S
L
V
E
R
V
E
-----
E
L
I
K
K
-
S
E
H
K
R
R
L
-
P
---------
I
G
P
----------------------------------------------