@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ08_V3_1000: (2017-09-12 )
MPVVHAFRASQSGLDAGAMKRSSDSHSPPFFFLSSACLAYRTSPMPSPRFARPELNGIITVRRFQRPQLETEAPIRKGDLKEPLEAVAGRVGLRARCSTSAPSADLCLVDDHELVLMGKLVDKGVYYITGGVCIDAEGSDTSSQSPTAALVSSTACGAAPQPPDITVGWCFDARMLLHRSDMNRSPETPHRLQRAIETLQGCERALDVLPVELLAPFTVHKDSSSGSDLGRAVPPISAANRSQWIPARLATYDEVCSFQDPQVYEHFLKSGAALVNLKSDVYCNDETSSVAVRLSAGAVIDASVAALRGVAASRSGTASSAAGRVHPLVSFCLVRPPGHHCTASQPSGFCLVNNVAIAVQQLRIRHASALPSGPPRIAILDLDVHFGEGTASFVEGACDPASLLYLSLHRYDKRQFYPFDGRGDTAYVGGSRHAASKGSICNVAVHTNGQQPARCEQVISDHLMNSVLEEIFLPRLAEFGPDLVMVSLGFDAAYGDPLGKMAVEGGFASVLSRLKWWCLHDGRTAGLVVVLEGGYNPEAVAQGVLSVALALSLPRTDPLLQRFLEEKSPKVWSDLRQRQERRHREWQQLREERAEEDVGAAPSGLGSELKPAASDEPEQVQEDALLLDRHKRWCAALVAKVQQIHREAMTRER
Atome Classification :
(40 SA)
----------------------------------------------------------------------.........10........20........30---........40........50....-...-----------------------------------------------------------------.60........70........80........90........100.......110.......120.......130.......140..---.....150.......160-----------........170......----------------.180---------------.---------------.-......190.......200------------........210..---.....220....---------...230.......240.......250.......260.......270--..---.----.--------------------....280--....---.....290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390........400.......410.......420.......430.......440.......450.......460.......470.......480.......490....--...500-.-.-.....510.......520.......-530.......540..---.....550....---...----------560.-.......570.......580.......590.......600.......610.......620.......630.......640.......650.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------------------------------MP
V
V
H
A
FRASQSGLDAGAMKRSSDSHSP
P
F
F
---
F
L
S
S
A
C
L
A
YRTSPMPSPRFARPEL-N
G
I
-----------------------------------------------------------------
I
T
V
R
RFQRPQLETEAPIRKG
D
L
K
E
P
L
E
A
V
A
G
RVG
L
R
A
RCSTSAPSA
D
L
C
L
VDDH
E
L
V
L
M
G
K
L
VDKG
V
Y
Y
I
TG
G
V
C
IDAEGSDTSSQ---SP
T
A
A
L
VSSTACGAAPQ------------PP
D
I
T
V
G
W
C
F
D
A
R
M
L
L
H
----------------RSD----------------M---------------N-RSPE
T
P
H
R
L
Q
R
A
I
E
T
L
Q
G
-------------
C
E
R
A
L
D
VL
P
V
E
LL---A
P
F
T
V
HKDSSSG---------SDLGRAVPPISAANRSQW
I
P
A
R
L
A
T
Y
D
E
VCSFQD
P
Q
V
Y
E
H
F
L
KSG---
A
A
---
L
----
V
--------------------NLKS
D
----
V
Y
CN---DET
S
S
V
A
V
R
L
SAG
A
V
I
D
A
S
V
A
A
L
R
G
VAASRSGTASSAAGR
V
H
P
L
V
S
F
CLVRPPGHHCTASQPS
G
F
C
L
V
N
N
V
A
I
A
V
Q
Q
L
R
I
R
H
ASALPSGP
P
R
I
A
I
L
D
L
D
V
HFGEG
T
-
A
S
F
V
EGAC
D
P
A
S
L
L
Y
L
S
L
HRY
D
K
RQFYPFDGRGD
T
A
Y
VGGSRHAASKG
S
I
C
N
V
A
V
HTNGQQ
P
A
R
C
E
Q
V
I
S
D
H
L
M
N
S
V
L
E
E
I
F
L
P
R
L
A
EFGP
D
L
V
M
V
S
LGFDAAYGD--P
L
G
K
M
A
-V-E-
G
G
F
A
S
V
L
S
R
L
K
W
W
C
LHDGR
T
A
G
L
V
V
-
V
L
EGGY
N
P
E
A
V
A
Q
G
V
---
L
S
V
A
L
A
LSLPRT---
D
P
L
----------
L
-
Q
R
-
F
L
E
EKS
P
K
V
W
S
D
L
R
Q
R
Q
E
R
R
H
R
E
W
Q
Q
L
R
E
E
R
AEEDVGAAPSGLGSELKPAASD
E
P
E
Q
V
Q
E
D
A
L
L
L
D
R
H
K
R
W
C
A
A
L
V
A
K
V
Q
Q
I
H
R
E
A
MTRER
86
Fugue
74.31
25%
6
* C2 *
-
5G0J
9
?
A:
[17-772]
VQGKS
K
A
T
G
T
G
L
V
Y
V
DAFTRFHCLWDASHPEC
P
A
R
V
S
T
V
M
E
M
L
E
T
E
GLLGRCV
Q
V
E
A
R
A
V
T
E
D
E
L
L
LVHT
K
E
Y
V
E
L
M
K
S
T
Q
N
-
M
T
E
E
E
L
K
T
L
A
E
K
Y
D
S
V
Y
L
H
PG
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
INRPPGHHAQADKMNGFCMFN
N
L
A
I
A
A
R
Y
A
Q
K
R
HRVQ
R
V
L
I
V
D
WDVHHG
Q
G
I
Q
Y
I
F
E
EDPS
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
G
A
G
Q
G
Y
N
I
N
L
P
W
N
-
K
V
G
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
--
F
D
A
V
I
G
D
P
K
G
G
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
Q
GR
L
V
L
A
L
E
G
GYN
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
G
DPCPHLPSSGAPC
E
S
A
L
K
S
----------------
I
---------------
S
-
K
T
I
S
D
L
Y
P
F
W
K
S
L
Q
T
F
E
G
GPLSEVSP
L
P
A
P
V
C
A
E
V
K
V
S
S
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
H
N
M
W
D
S
HHPELPQ
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
I
K
S
S
E
HMK
P
R
---
D
----
L
--------------------
N
R
L
G
D
----
E
Y
N
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
--------------
T
G
Q
V
R
N
A
V
A
--
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
-----
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
---
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
-----
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
-------
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
T
P
-
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
--
A
G
R
---
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
---
S
M
C
T
S
M
L
-------------------------------------------------------------
L
G
D
S
P
P
S
L
D
H
-
L
T
P
L
K
T
S
A
T
V
S
I
N
N
---
V
L
R
A
H
A
P
F
W
S
S
L
R
V
N
I
P
E
S
L
R
L
S
L
----
58
HHSearch
73.17
30%
-20
- C3 -
-
2VQJ
9
A:
[6-389]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
----------------
Q
C
T
CGS-------------
S
---------------
S
-
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
-------------
T
G
L
----------------------------------------------
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
---
L
N
R
Q
K
L
----
D
S
K
K
L
L
G
S
L
A
S
V
F
VRLPCGGV
G
V
D
S
D
----
T
I
W
N
---
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
----------------
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
------
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
Q
A
F
Y
S
D
P
S
---
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
--
S
G
A
P
D
E
V
G
T
G
---
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
------
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
PT
P
L
G
G
Y
N
-
L
-
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
--
G
---
G
R
I
V
L
-
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
---
E
A
C
V
S
A
L
L
G
N
E
L
---
D
P
L
----------
P
-
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
--------------------------------------------------------------
6
PsiBlast_PDB
72.57
28%
-17
- C3 -
-
5EEM
5
?
B:
[8-363]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
----------------
W
---------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
-------------------------------------
F
S
R
H
E
E
----------------------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
-
H
I
S
I
I
K
S
S
---
E
H
---
M
KPRD
L
--------------------
N
R
L
G
D
EYNS
I
F
I
S
---
N
E
S
Y
T
C
A
L
-
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
--
R
N
A
V
A
--------------
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
-----
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
---
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
-----
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
-------
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
--
S
L
A
A
G
R
---
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
SMC
T
S
M
L
L
G
D
S
P
P
S
------
L
TPLKTSATVS
I
-
N
N
-
V
L
R
A
H
A
P
-
F
W
S
S
L
------------------------------------------------------------------------------
69
HHSearch
72.46
24%
-48
- C3 -
-
5G1A
10
HDAH_ALCSD
A:
[3-369]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
I
G
Y
V
W
N
T
L
Y
G
W
V
----------------
D
T
G
----------------
T
GSLAAANLTARMQPI
S
-
H
H
L
A
H
P
D
T
K
R
R
F
H
E
L
V
C
A
-------------
S
G
Q
----------------------------------------------
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
L
E
N
M
K
R
V
S
---
N
L
---
P
TGG-
D
--------------------
T
G
D
G
I
----
T
M
M
G
---
N
G
-
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
----------------
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
------
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
-
Q
D
I
W
W
N
D
P
S
---
V
L
T
I
S
L
H
Q
H
L
--
C
-
F
P
P
-
D
S
G
Y
S
T
E
R
G
A
G
---
N
G
H
G
Y
N
I
N
V
P
L
P
P
G
----------
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
S
M
L
D
--
P
L
A
R
M
M
-
V
-
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
-
I
C
D
G
R
I
V
F
-
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
---
L
A
V
I
E
E
L
T
G
V
R
S
---
L
P
D
----------
P
Y
H
E
-
F
L
A
--
G
M
G
G
N
T
L
L
D
A
E
R
A
A
I
E
-
I
V
P
L
L
A
D
--------------------------------------------------------------
2
PsiBlast_PDB
72.34
28%
-8
- C3 -
-
5G0J
5
?
A:
[382-761]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
G
P
L
S
E
V
---
S
P
L
P
A
P
V
C
A
E
V
K
V
S
S
P
-----------------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
----------------
W
---------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
-------------------------------------
F
S
R
H
E
E
----------------------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
-
H
I
S
I
I
K
S
S
---
E
H
---
M
K
P
R
D
L
--------------------
N
R
L
G
D
EYNS
I
F
I
S
---
N
E
S
Y
T
C
A
L
-
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
--
R
N
A
V
A
--------------
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
-----
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
---
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
-----
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
-------
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
--
S
L
A
A
G
R
---
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
---
D
H
L
TPLK
T
S
A
T
V
S
I
-
N
N
-
V
L
R
A
H
A
P
-
F
W
S
S
L
R
-----------------------------------------------------------------------------
62
HHSearch
72.19
30%
-17
- C3 -
-
5G0X
8
HDAH_PSEAE
A:
[2-357]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
T
A
F
F
F
D
E
L
C
L
W
H
----------------
A
A
G
P
HALTLPVGGWVQPPA
A
---------------
A
-
G
H
A
E
S
P
E
T
K
R
R
L
K
S
L
L
D
V
-------------
S
G
L
----------------------------------------------
T
A
R
L
Q
L
R
S
A
P
P
A
S
D
E
D
L
L
R
V
H
P
A
H
Y
L
E
R
F
K
A
L
S
---
D
A
G--
G
----
G
--------------------
S
L
G
Q
D
----
A
P
I
G
---
P
G
-
S
Y
E
I
A
R
L
S
A
G
L
A
I
A
A
L
D
A
V
L
A
G
----------------
E
A
D
N
A
Y
S
L
S
R
P
P
G
H
H
C
L
P
D
Q
A
M
G
F
C
F
F
A
N
I
A
V
A
I
E
A
A
K
A
R
H
------
G
V
E
R
V
A
V
L
D
W
D
V
H
H
G
N
G
T
-
Q
A
I
Y
Y
R
R
D
D
---
V
L
S
I
S
L
H
Q
D
G
--
C
F
P
P
G
--
Y
S
G
A
E
D
I
G
E
D
---
R
G
R
G
F
N
L
N
V
P
L
L
P
G
----------
G
G
H
D
A
Y
M
Q
A
M
Q
R
I
V
L
P
A
L
E
R
F
R
P
Q
L
I
V
V
A
S
G
F
D
A
N
A
V
D
--
P
L
A
R
M
Q
-
L
-
H
S
D
S
F
R
A
M
T
A
M
V
R
D
A
A
E
R
-
H
A
G
G
R
L
V
V
-
V
H
E
G
G
Y
S
E
A
Y
V
P
F
C
G
---
L
A
V
I
E
E
L
S
G
V
R
S
---
A
V
-------------------------
R
D
P
L
R
D
F
I
E
L
Q
Q
P
N
A
A
F
R
D
F
Q
R
------------------------------------------------------------
68
HHSearch
72.04
24%
-45
- C3 -
-
5G1B
7
HDAH_ALCSD
A:
[3-369]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
I
G
Y
V
W
N
T
L
Y
G
W
V
----------------
D
T
G
----------------
T
GSLAAANLTARMQPI
S
-
H
H
L
A
H
P
D
T
K
R
R
F
H
E
L
V
C
A
-------------
S
G
Q
----------------------------------------------
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
L
E
N
M
K
R
V
S
---
N
L
---
P
TGG-
D
--------------------
T
G
D
G
I
----
T
M
M
G
---
N
G
-
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
----------------
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
------
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
-
Q
D
I
W
W
N
D
P
S
---
V
L
T
I
S
L
H
Q
H
L
--
C
-
F
P
P
-
D
S
G
Y
S
T
E
R
G
A
G
---
N
G
H
G
Y
N
I
N
V
P
L
P
P
G
----------
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
S
M
L
D
--
P
L
A
R
M
M
-
V
-
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
-
I
C
D
G
R
I
V
F
-
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
---
L
A
V
I
E
E
L
T
G
V
R
S
---
L
P
D
----------
P
Y
H
E
-
F
L
A
--
G
M
G
G
N
T
L
L
D
A
E
R
A
A
I
E
E
I
V
P
L
L
A
D
--------------------------------------------------------------
63
HHSearch
71.92
30%
-18
- C3 -
-
5G0Y
3
HDAH_PSEAE
B:
[2-357]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
T
A
F
F
F
D
E
L
C
L
W
H
----------------
A
A
G
PHALTLPVGGWVQPPA
A
---------------
A
-
G
H
A
E
S
P
E
T
K
R
R
L
K
S
L
L
D
V
-------------
S
G
L
----------------------------------------------
T
A
R
L
Q
L
R
S
A
P
P
A
S
D
E
D
L
L
R
V
H
P
A
H
Y
L
E
R
F
K
A
L
S
---
D
A
G--
G
----
G
--------------------
S
L
G
Q
D
----
A
P
I
G
---
P
G
-
S
Y
E
I
A
R
L
S
A
G
L
A
I
A
A
L
D
A
V
L
A
G
----------------
E
A
D
N
A
Y
S
L
S
R
P
P
G
H
H
C
L
P
D
Q
A
M
G
F
C
F
F
A
N
I
A
V
A
I
E
A
A
K
A
R
H
------
G
V
E
R
V
A
V
L
D
W
D
V
H
H
G
N
G
T
-
Q
A
I
Y
Y
R
R
D
D
---
V
L
S
I
S
L
H
Q
D
G
--
C
F
P
P
G
--
Y
S
G
A
E
D
I
G
E
D
---
R
G
R
G
F
N
L
N
V
P
L
L
P
G
----------
G
G
H
D
A
Y
M
Q
A
M
Q
R
I
V
L
P
A
L
E
R
F
R
P
Q
L
I
V
V
A
S
G
F
D
A
N
A
V
D
--
P
L
A
R
M
Q
-
L
-
H
S
D
S
F
R
A
M
T
A
M
V
R
D
A
A
E
R
-
H
A
G
G
R
L
V
V
-
V
H
E
G
G
Y
S
E
A
Y
V
P
F
C
G
---
L
A
V
I
E
E
L
S
G
V
R
S
---
A
V
-------------------------
R
D
P
L
R
D
F
I
E
L
Q
Q
P
N
A
A
F
R
D
F
Q
R
------------------------------------------------------------
13
PsiBlast_PDB
71.27
28%
-10
- C3 -
-
5EFJ
9
?
D:
[8-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
----------------
W
---------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
-------------------------------------
F
S
R
H
E
E
----------------------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
-
H
I
S
I
I
K
S
S
---
E
H
---
M
KPRD
L
--------------------
N
R
L
G
D
EYNS
I
F
I
S
---
N
E
S
Y
T
C
A
L
-
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
--
R
N
A
V
A
--------------
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
-----
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
---
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
-----
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
-------
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
--
S
L
A
A
G
R
---
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
SMC
T
S
M
L
L
G
D
S
P
P
S
L
----
H
L
TPLKTSATVS
I
-
N
N
-
V
L
R
A
H
A
P
-
F
W
S
S
L
R
-----------------------------------------------------------------------------
5
PsiBlast_PDB
71.24
28%
-12
- C3 -
-
5EEK
30
?
A:
[7-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
-----------------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
----------------
W
---------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
-------------------------------------
F
S
R
H
E
E
----------------------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
-
H
I
S
I
I
K
S
S
---
E
H
---
M
K
P
R
D
L
--------------------
N
R
L
G
D
E
Y
NS
I
F
I
S
---
N
E
S
Y
T
C
A
L
-
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
--
R
N
A
V
A
--------------
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
-----
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
---
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
-----
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
-------
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
--
S
L
A
A
G
R
---
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
-----
L
TPLK
T
S
A
T
V
S
I
-
N
N
-
V
L
R
A
H
A
P
-
F
W
S
S
L
R
-----------------------------------------------------------------------------
71
HHSearch
71.04
30%
-55
- C3 -
-
5JI5
6
?
A:
[10-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
G
F
Y
S
H
A
D
C
L
Q
H
----------------
E
M
G
--------------------------------
Q
-
W
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
-------------
S
R
I
----------------------------------------------
G
E
L
I
E
R
E
S
A
P
L
A
D
E
A
A
L
L
R
V
H
T
K
A
H
V
D
Y
L
R
A
R
S
---
P
Q
---
S
GY--
A
--------------------
E
I
D
P
D
----
T
S
M
N
---
P
H
-
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
----------------
R
Y
D
N
A
F
C
S
V
R
P
P
G
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
V
H
------
K
L
E
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
-
E
A
A
F
S
N
D
A
R
---
V
L
M
C
S
I
F
Q
H
---
P
F
Y
P
F
--
T
G
A
D
N
---------
Q
A
P
N
M
C
N
V
P
I
A
A
R
----------
S
K
G
M
V
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
E
D
--
D
L
G
N
M
A
-
L
-
V
E
D
D
Y
A
W
I
T
Q
Q
I
R
L
V
A
D
K
Y
-
A
K
G
R
I
V
S
-
C
L
E
G
G
Y
N
L
S
A
L
G
R
S
V
---
V
A
H
V
R
A
L
A
D
-------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.81
28%
-12
- C3 -
-
5EFB
4
?
D:
[8-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
----------------
W
---------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
-------------------------------------
F
S
R
H
E
E
----------------------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
-
H
I
S
I
I
K
S
S
---
E
H
---
M
KPRD
L
--------------------
N
R
L
G
D
EYNS
I
F
I
S
---
N
E
S
Y
T
C
A
L
-
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
--
R
N
A
V
A
--------------
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
-----
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
---
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
-----
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
-------
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
--
S
L
A
A
G
R
---
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
SMC
T
S
M
L
L
G
D
S
P
P
S
L
-----
L
TPLKTSATVS
I
-
N
N
-
V
L
R
A
H
A
P
-
F
W
S
S
L
R
-----------------------------------------------------------------------------
14
PsiBlast_PDB
70.62
28%
-13
- C3 -
-
5EFK
8
?
B:
[9-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
----------------
W
---------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
-------------------------------------
F
S
R
H
E
E
----------------------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
-
H
I
S
I
I
K
S
S
---
E
H
---
M
K
P
R
D
L
--------------------
N
R
L
G
D
E
Y
NS
I
F
I
S
---
N
E
S
Y
T
C
A
L
-
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
--
R
N
A
V
A
--------------
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
-----
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
---
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
-----
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
-------
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
--
S
L
A
A
G
R
---
V
L
I
-
I
L
E
G
G
F
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
----
H
L
TPLK
T
S
A
T
V
S
I
-
N
N
-
V
L
R
A
H
A
P
-
F
W
S
S
L
R
-----------------------------------------------------------------------------
7
PsiBlast_PDB
70.53
28%
-14
- C3 -
-
5EEN
4
?
B:
[8-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
----------------
W
---------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
-------------------------------------
F
S
R
H
E
E
----------------------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
-
H
I
S
I
I
K
S
S
---
E
H
---
M
KPRD
L
--------------------
N
R
L
G
D
EYNS
I
F
I
S
---
N
E
S
Y
T
C
A
L
-
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
--
R
N
A
V
A
--------------
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
-----
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
---
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
-----
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
-------
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
--
S
L
A
A
G
R
---
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
SMC
T
S
M
L
L
G
D
S
P
P
S
L
------PLKTSATVS-
I
-
N
N
-
V
L
R
A
H
A
P
-
F
W
S
S
L
R
-----------------------------------------------------------------------------
11
PsiBlast_PDB
70.36
28%
-8
- C3 -
-
5EFG
4
?
D:
[8-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
----------------
W
---------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
-------------------------------------
F
S
R
H
E
E
----------------------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
-
H
I
S
I
I
K
S
S
---
E
H
---
M
KPRD
L
--------------------
N
R
L
G
D
EYNS
I
F
I
S
---
N
E
S
Y
T
C
A
L
-
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
--
R
N
A
V
A
--------------
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
-----
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
---
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
-----
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
-------
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
--
S
L
A
A
G
R
---
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
SMC
T
S
M
L
L
G
D
S
P
P
S
L
---
D
H
L
TPLKTSATVS
I
-
N
N
-
V
L
R
A
H
A
P
-
F
W
S
S
L
R
-----------------------------------------------------------------------------
8
PsiBlast_PDB
70.34
28%
-10
- C3 -
-
5EF7
4
?
A:
[7-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
-----------------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
----------------
W
---------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
-------------------------------------
F
S
R
H
E
E
----------------------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
-
H
I
S
I
I
K
S
S
---
E
H
---
M
K
P
R
D
L
--------------------
N
R
L
G
D
E
Y
NS
I
F
I
S
---
N
E
S
Y
T
C
A
L
-
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
--
R
N
A
V
A
--------------
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
-----
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
---
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
-----
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
-------
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
--
S
L
A
A
G
R
---
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
---
D
H
L
TPLK
T
S
A
T
V
S
I
-
N
N
-
V
L
R
A
H
A
P
-
F
W
S
S
L
R
-----------------------------------------------------------------------------
12
PsiBlast_PDB
70.23
28%
-8
- C3 -
-
5EFH
7
?
D:
[9-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
----------------
W
---------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
-------------------------------------
F
-
R
H
E
E
----------------------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
-
H
I
S
I
I
K
S
S
---
E
H
---
M
KPRD
L
--------------------
N
R
L
G
D
EYNS
I
F
I
S
---
N
E
S
Y
T
C
A
L
-
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
--
R
N
A
V
A
--------------
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
-----
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
---
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
-----
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
-------
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
--
S
L
A
A
G
R
---
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
SMC
T
S
M
L
L
G
D
S
P
P
S
L
---
D
H
L
TPLKTSATVS
I
-
N
N
-
V
L
R
A
H
A
P
-
F
W
S
S
L
R
-----------------------------------------------------------------------------
64
HHSearch
70.12
28%
-6
* C3 *
-
5EFG
4
?
A:
[7-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
W---------------
D
---------------
S
-
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
-------------
L
R
L
----------------------------------------------
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
I
K
S
S
E
---
H
M
---
K
P
R
D
L
N
R
L
G
-----------------
D
E
Y
N
S
----
I
F
I
S
---
N
E
-
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
----------------
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
-----
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
E
D
D
S
---
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
---
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---------
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
--
A
---
G
R
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
---
S
M
C
T
S
M
L
L
G
D
S
P
---
P
S
L
------------
D
H
-
L
T
-
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
---------------------------------------------------------------
65
HHSearch
69.58
28%
-5
- C3 -
-
5EEI
12
?
A:
[8-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
W---------------
D
---------------
S
-
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
-------------
L
R
L
----------------------------------------------
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
I
K
S
S
E
---
H
M
---
K
P
R
D
L
N
R
L
G
-----------------
D
E
Y
N
S
----
I
F
I
S
---
N
E
-
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
----------------
Q
V
R
N
A
V
A
I
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
-----
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
E
D
D
S
---
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
L
G
---
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---------
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
--
A
---
G
R
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
---
S
M
C
T
S
M
L
L
G
D
S
P
---
P
S
L
------------
D
H
-
L
T
-
P
L
K
T
S
A
T
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
---------------------------------------------------------------
15
PsiBlast_PDB
69.57
28%
-9
- C3 -
-
5EFN
6
?
B:
[8-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------
I
T
G
L
V
Y
D
Q
R
M
M
L
H
----------------
H
N
M
----------------
W
---------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
-------------------------------------
F
S
R
H
E
E
----------------------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
C
H
S
S
K
-
H
I
S
I
I
K
S
S
---
E
H
---
M
KPRD
L
--------------------
N
R
L
G
D
EYNS
I
F
I
S
---
N
E
S
Y
T
C
A
L
-
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
--
R
N
A
V
A
--------------
I
V
R
P
P
G
H
A
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
-----
L
T
A
R
Y
A
Q
S
I
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
-
Q
H
I
F
E
---
E
D
D
S
V
L
Y
I
S
L
H
R
Y
E
D
G
A
F
F
P
N
S
E
D
A
N
Y
D
K
V
G
-----
L
G
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
-------
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
-
V
-
T
P
E
G
Y
A
H
L
T
H
Q
L
M
--
S
L
A
A
G
R
---
V
L
I
-
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
SMC
T
S
M
L
L
G
D
S
P
P
S
L
---
D
H
L
TPLKTSATVS
I
-
N
N
-
V
L
R
A
H
A
P
-
F
W
S
S
L
R
-----------------------------------------------------------------------------
50
PsiBlast_CBE
68.60
31%
-114
- C3 -
-
5G11
5
HDAH_PSEAE
B:
[112-358]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
S
A
G
L
A
I
A
A
L
D
A
V
L
A
G
E
A
D
N
----------------
A
Y
S
L
S
R
P
P
G
H
H
C
L
P
D
Q
A
M
G
F
C
F
F
A
N
I
A
V
A
I
E
A
A
K
A
R
H
------
G
V
E
R
V
A
V
L
D
W
D
V
H
H
G
N
G
T
-
Q
A
I
Y
Y
R
R
D
D
---
V
L
S
I
S
L
H
Q
--
D
G
C
F
P
P
--
G
Y
S
G
A
E
D
I
G
E
D
R
---
G
R
G
F
N
L
N
V
P
L
L
P
G
G
G
H
D
A
Y
M
Q
----------
A
M
Q
R
I
V
L
P
A
L
E
R
F
R
P
Q
L
I
V
V
A
S
G
F
D
A
N
A
V
D
--
P
L
A
R
M
Q
-
L
-
H
-
S
D
S
F
R
A
M
T
A
M
V
R
D
A
A
E
R
H
A
G
G
R
L
V
V
-
V
H
E
G
G
F
S
E
A
Y
V
P
F
C
G
---
L
A
V
I
E
E
L
S
G
V
R
S
AVR
D
P
-----------
L
-
R
D
-
F
I
E
L
Q
Q
P
N
A
A
F
R
D
F
Q
R
Q
--------------------------------------------------------------------------
42
PsiBlast_CBE
68.11
32%
-114
- C3 -
-
5G10
5
HDAH_PSEAE
B:
[112-358]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
S
A
G
L
A
I
A
A
L
D
A
V
L
A
G
E
A
D
N
----------------
A
Y
S
L
S
R
P
P
G
H
H
C
L
P
D
Q
A
M
G
F
C
F
F
A
N
I
A
V
A
I
E
A
A
K
A
R
H
------
G
V
E
R
V
A
V
L
D
W
D
V
H
H
G
N
G
T
-
Q
A
I
Y
Y
R
R
D
D
---
V
L
S
I
S
L
H
Q
--
D
G
C
F
P
P
--
G
Y
S
G
A
E
D
I
G
E
D
R
---
G
R
G
F
N
L
N
V
P
L
L
P
G
G
G
H
D
A
Y
M
Q
----------
A
M
Q
R
I
V
L
P
A
L
E
R
F
R
P
Q
L
I
V
V
A
S
G
F
D
A
N
A
V
D
--
P
L
A
R
M
Q
-
L
-
H
-
S
D
S
F
R
A
M
T
A
M
V
R
D
A
A
E
R
H
A
G
G
R
L
V
V
-
V
H
E
G
G
Y
S
E
A
Y
V
P
F
C
G
---
L
A
V
I
E
E
L
S
G
V
R
S
AVR
D
P
-----------
L
-
R
D
-
F
I
E
L
Q
Q
P
N
A
A
F
R
D
F
Q
R
Q
--------------------------------------------------------------------------
43
PsiBlast_CBE
67.82
32%
-115
- C3 -
-
5G10
5
HDAH_PSEAE
A:
[112-358]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
S
A
G
L
A
I
A
A
L
D
A
V
L
A
G
E
A
D
N
----------------
A
Y
S
L
S
R
P
P
G
H
H
C
L
P
D
Q
A
M
G
F
C
F
F
A
N
I
A
V
A
I
E
A
A
K
A
R
H
------
G
V
E
R
V
A
V
L
D
W
D
V
H
H
G
N
G
T
-
Q
A
I
Y
Y
R
R
D
D
---
V
L
S
I
S
L
H
Q
--
D
G
C
F
P
P
--
G
Y
S
G
A
E
D
I
G
E
D
R
---
G
R
G
F
N
L
N
V
P
L
L
P
G
G
G
H
D
A
Y
M
Q
----------
A
M
Q
R
I
V
L
P
A
L
E
R
F
R
P
Q
L
I
V
V
A
S
G
F
D
A
N
A
V
D
--
P
L
A
R
M
Q
-
L
-
H
-
S
D
S
F
R
A
M
T
A
M
V
R
D
A
A
E
R
H
A
G
G
R
L
V
V
-
V
H
E
G
G
Y
S
E
A
Y
V
P
F
C
G
---
L
A
V
I
E
E
L
S
G
V
R
S
AVR
D
P
-----------
L
-
R
D
-
F
I
E
L
Q
Q
P
N
A
A
F
R
D
F
Q
R
Q
--------------------------------------------------------------------------
41
PsiBlast_CBE
66.98
32%
-114
- C3 -
-
5LI3
5
HDAH_PSEAE
A:
[113-359]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
S
A
G
L
A
I
A
A
L
D
A
V
L
A
G
E
A
D
N
----------------
A
Y
S
L
S
R
P
P
G
H
H
C
L
P
D
Q
A
M
G
F
C
F
F
A
N
I
A
V
A
I
E
A
A
K
A
R
H
------
G
V
E
R
V
A
V
L
D
W
D
V
H
H
G
N
G
T
-
Q
A
I
Y
Y
R
R
D
D
---
V
L
S
I
S
L
H
Q
--
D
G
C
F
P
P
--
G
Y
S
G
A
E
D
I
G
E
D
R
---
G
R
G
F
N
L
N
V
P
L
L
P
G
G
G
H
D
A
Y
M
Q
----------
A
M
Q
R
I
V
L
P
A
L
E
R
F
R
P
Q
L
I
V
V
A
S
G
F
D
A
N
A
V
D
--
P
L
A
R
M
Q
-
L
-
H
-
S
D
S
F
R
A
M
T
A
M
V
R
D
A
A
E
R
H
A
G
G
R
L
V
V
-
V
H
E
G
G
Y
S
E
A
Y
V
P
F
C
G
---
L
A
V
I
E
E
L
S
G
V
R
S
AVR
D
P
-----------
L
-
R
D
-
F
I
E
L
Q
Q
P
N
A
A
F
R
D
F
Q
R
Q
--------------------------------------------------------------------------
32
PsiBlast_CBE
66.91
33%
-70
- C3 -
-
3C10
4
HDAC7_HUMAN
A:
[141-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------
G
V
D
T
D
----
T
I
W
N
---
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
-----
A
S
R
E
L
K
N
G
-----------
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
------
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
---
D
P
-
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
-----
S
G
E
G
F
N
V
N
V
A
W
-
A
G
G
L
D
P
P
-----
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
PA
P
L
G
G
Y
H
-
V
-
S
-
A
K
C
F
G
Y
M
T
Q
Q
----
L
M
N
L
A
G
G
A
V
V
L
-
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
---
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
----------
S
-
E
E
-
G
W
K
Q
K
--------------------------------------------------------------------------------------
40
PsiBlast_CBE
66.84
32%
-113
- C3 -
-
5LI3
5
HDAH_PSEAE
B:
[113-359]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
S
A
G
L
A
I
A
A
L
D
A
V
L
A
G
E
A
D
N
----------------
A
Y
S
L
S
R
P
P
G
H
H
C
L
P
D
Q
A
M
G
F
C
F
F
A
N
I
A
V
A
I
E
A
A
K
A
R
H
------
G
V
E
R
V
A
V
L
D
W
D
V
H
H
G
N
G
T
-
Q
A
I
Y
Y
R
R
D
D
---
V
L
S
I
S
L
H
Q
--
D
G
C
F
P
P
--
G
Y
S
G
A
E
D
I
G
E
D
R
---
G
R
G
F
N
L
N
V
P
L
L
P
G
G
G
H
D
A
Y
M
Q
----------
A
M
Q
R
I
V
L
P
A
L
E
R
F
R
P
Q
L
I
V
V
A
S
G
F
D
A
N
A
V
D
--
P
L
A
R
M
Q
-
L
-
H
-
S
D
S
F
R
A
M
T
A
M
V
R
D
A
A
E
R
H
A
G
G
R
L
V
V
-
V
H
E
G
G
Y
S
E
A
Y
V
P
F
C
G
---
L
A
V
I
E
E
L
S
G
V
R
S
AVR
D
P
-----------
L
-
R
D
-
F
I
E
L
Q
Q
P
N
A
A
F
R
D
F
Q
R
Q
--------------------------------------------------------------------------
35
PsiBlast_CBE
66.17
33%
-70
- C3 -
-
3C0Z
4
HDAC7_HUMAN
A:
[141-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------
G
V
D
T
D
----
T
I
W
N
---
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
-----
A
S
R
E
L
K
N
G
-----------
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
------
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
---
D
P
-
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
-----
S
G
E
G
F
N
V
N
V
A
W
-
A
G
G
L
D
P
P
-----
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
PA
P
L
G
G
Y
H
-
V
-
S
-
A
K
C
F
G
Y
M
T
Q
Q
----
L
M
N
L
A
G
G
A
V
V
L
-
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
---
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
----------
S
-
E
E
-
G
W
K
Q
K
--------------------------------------------------------------------------------------
51
PsiBlast_CBE
66.06
31%
-113
- C3 -
-
5G11
5
HDAH_PSEAE
A:
[112-358]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
S
A
G
L
A
I
A
A
L
D
A
V
L
A
G
E
A
D
N
----------------
A
Y
S
L
S
R
P
P
G
H
H
C
L
P
D
Q
A
M
G
F
C
F
F
A
N
I
A
V
A
I
E
A
A
K
A
R
H
------
G
V
E
R
V
A
V
L
D
W
D
V
H
H
G
N
G
T
-
Q
A
I
Y
Y
R
R
D
D
---
V
L
S
I
S
L
H
Q
--
D
G
C
F
P
P
--
G
Y
S
G
A
E
D
I
G
E
D
R
---
G
R
G
F
N
L
N
V
P
L
L
P
G
G
G
H
D
A
Y
M
Q
----------
A
M
Q
R
I
V
L
P
A
L
E
R
F
R
P
Q
L
I
V
V
A
S
G
F
D
A
N
A
V
D
--
P
L
A
R
M
Q
-
L
-
H
-
S
D
S
F
R
A
M
T
A
M
V
R
D
A
A
E
R
H
A
G
G
R
L
V
V
-
V
H
E
G
G
F
S
E
A
Y
V
P
F
C
G
---
L
A
V
I
E
E
L
S
G
V
R
S
AVR
D
P
-----------
L
-
R
D
-
F
I
E
L
Q
Q
P
N
A
A
F
R
D
F
Q
R
Q
--------------------------------------------------------------------------
34
PsiBlast_CBE
66.00
33%
-74
- C3 -
-
3C0Z
4
HDAC7_HUMAN
B:
[141-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------
G
V
D
T
D
----
T
I
W
N
---
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
-----
A
S
R
E
L
K
N
G
-----------
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
------
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
---
D
P
-
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
-----
S
G
E
G
F
N
V
N
V
A
W
-
A
G
G
L
D
P
P
-----
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
PA
P
L
G
G
Y
H
-
V
-
S
-
A
K
C
F
G
Y
M
T
Q
Q
----
L
M
N
L
A
G
G
A
V
V
L
-
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
---
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
----------
S
-
E
E
-
G
W
K
Q
K
--------------------------------------------------------------------------------------
29
PsiBlast_CBE
65.25
33%
-66
- C3 -
-
3ZNR
4
HDAC7_HUMAN
A:
[141-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------
G
V
D
T
D
----
T
I
W
N
---
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
-----
A
S
R
E
L
K
N
G
-----------
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
------
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
---
D
P
-
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
-----
S
G
E
G
F
N
V
N
V
A
W
-
A
G
G
L
D
P
P
-----
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
PA
P
L
G
G
Y
H
-
V
-
S
-
A
K
C
F
G
Y
M
T
Q
Q
----
L
M
N
L
A
G
G
A
V
V
L
-
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
---
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
----------
S
-
E
E
-
G
W
K
Q
K
--------------------------------------------------------------------------------------
25
PsiBlast_CBE
65.21
33%
-66
- C3 -
-
3ZNS
4
HDAC7_HUMAN
B:
[141-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------
G
V
D
T
D
----
T
I
W
N
---
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
-----
A
S
R
E
L
K
N
G
-----------
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
------
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
---
D
P
-
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
-----
S
G
E
G
F
N
V
N
V
A
W
-
A
G
G
L
D
P
P
-----
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
PA
P
L
G
G
Y
H
-
V
-
S
-
A
K
C
F
G
Y
M
T
Q
Q
----
L
M
N
L
A
G
G
A
V
V
L
-
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
---
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
----------
S
-
E
E
-
G
W
K
Q
K
--------------------------------------------------------------------------------------
24
PsiBlast_CBE
64.72
33%
-66
- C3 -
-
3ZNS
4
C:
[141-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------
G
V
D
T
D
----
T
I
W
N
---
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
-----
A
S
R
E
L
K
N
G
-----------
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
------
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
---
D
P
-
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
-----
S
G
E
G
F
N
V
N
V
A
W
-
A
G
G
L
D
P
P
-----
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
PA
P
L
G
G
Y
H
-
V
-
S
-
A
K
C
F
G
Y
M
T
Q
Q
----
L
M
N
L
A
G
G
A
V
V
L
-
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
---
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
----------
S
-
E
E
-
G
W
K
Q
K
--------------------------------------------------------------------------------------
31
PsiBlast_CBE
64.71
33%
-68
- C3 -
-
3C10
4
HDAC7_HUMAN
B:
[141-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------
G
V
D
T
D
----
T
I
W
N
---
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
-----
A
S
R
E
L
K
N
G
-----------
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
------
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
---
D
P
-
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
-----
S
G
E
G
F
N
V
N
V
A
W
-
A
G
G
L
D
P
P
-----
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
PA
P
L
G
G
Y
H
-
V
-
S
-
A
K
C
F
G
Y
M
T
Q
Q
----
L
M
N
L
A
G
G
A
V
V
L
-
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
---
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
----------
S
-
E
E
-
G
W
K
Q
K
--------------------------------------------------------------------------------------
30
PsiBlast_CBE
64.69
33%
-70
- C3 -
-
3C10
4
C:
[141-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------
G
V
D
T
D
----
T
I
W
N
---
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
-----
A
S
R
E
L
K
N
G
-----------
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
------
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
---
D
P
-
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
-----
S
G
E
G
F
N
V
N
V
A
W
-
A
G
G
L
D
P
P
-----
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
PA
P
L
G
G
Y
H
-
V
-
S
-
A
K
C
F
G
Y
M
T
Q
Q
----
L
M
N
L
A
G
G
A
V
V
L
-
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
---
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
----------
S
-
E
E
-
G
W
K
Q
K
--------------------------------------------------------------------------------------
33
PsiBlast_CBE
64.65
33%
-72
- C3 -
-
3C0Z
4
C:
[141-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------
G
V
D
T
D
----
T
I
W
N
---
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
-----
A
S
R
E
L
K
N
G
-----------
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
------
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
---
D
P
-
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
-----
S
G
E
G
F
N
V
N
V
A
W
-
A
G
G
L
D
P
P
-----
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
PA
P
L
G
G
Y
H
-
V
-
S
-
A
K
C
F
G
Y
M
T
Q
Q
----
L
M
N
L
A
G
G
A
V
V
L
-
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
---
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
----------
S
-
E
E
-
G
W
K
Q
K
--------------------------------------------------------------------------------------
26
PsiBlast_CBE
64.62
33%
-65
- C3 -
-
3ZNS
4
HDAC7_HUMAN
A:
[141-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------
G
V
D
T
D
----
T
I
W
N
---
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
-----
A
S
R
E
L
K
N
G
-----------
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
------
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
---
D
P
-
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
-----
S
G
E
G
F
N
V
N
V
A
W
-
A
G
G
L
D
P
P
-----
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
PA
P
L
G
G
Y
H
-
V
-
S
-
A
K
C
F
G
Y
M
T
Q
Q
----
L
M
N
L
A
G
G
A
V
V
L
-
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
---
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
----------
S
-
E
E
-
G
W
K
Q
K
--------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.35
36%
-122
- C3 -
-
5EEF
5
?
A:
[131-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
R
V
Q
------
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
-
Q
Y
I
F
E
E
--
D
P
-
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
---
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
V
G
M
E
S
G
-------
D
Y
I
--
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
--
P
K
G
G
M
Q
-
V
-
S
-
P
E
C
F
S
I
L
T
H
M
----
L
K
G
V
A
Q
G
R
L
V
L
-
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
-------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.28
36%
-118
- C3 -
-
5G0G
5
?
A:
[146-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
R
V
Q
------
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
-
Q
Y
I
F
E
E
--
D
P
-
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
---
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
V
G
M
E
S
G
-------
D
Y
I
--
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
--
P
K
G
G
M
Q
-
V
-
S
-
P
E
C
F
S
I
L
T
H
M
----
L
K
G
V
A
Q
G
R
L
V
L
-
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
-------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
63.03
36%
-116
- C3 -
-
5EEF
6
?
B:
[131-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
I
N
R
P
P
G
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
R
V
Q
------
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
-
Q
Y
I
F
E
E
--
D
P
-
S
V
L
Y
F
S
V
H
R
Y
E
D
G
S
F
W
P
H
L
K
E
S
D
S
S
S
V
G
S
---
G
A
G
Q
G
Y
N
I
N
L
P
W
N
K
V
G
M
E
S
G
-------
D
Y
I
--
T
A
F
Q
Q
L
L
L
P
V
A
Y
E
F
Q
P
Q
L
V
L
V
A
A
G
F
D
A
V
I
G
D
--
P
K
G
G
M
Q
-
V
-
S
-
P
E
C
F
S
I
L
T
H
M
----
L
K
G
V
A
Q
G
R
L
V
L
-
A
L
E
G
G
Y
N
L
Q
S
T
A
E
G
V
-------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
55.92
35%
-60
- C3 -
-
5JI5
4
?
A:
[124-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
C
S
V
R
P
P
G
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
-----
R
H
A
L
E
V
-
H
K
L
E
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
----
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
---
P
F
Y
P
F
T
G
A
D
N
Q
A
-----------
P
N
M
C
N
V
P
I
------
A
A
R
S
K
G
M
V
----
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
E
D
--
D
L
G
N
M
A
L
V
-
E
-
D
D
Y
A
W
I
T
Q
Q
I
R
--
L
V
A
D
K
Y
A
K
G
R
I
V
S
C
L
E
G
G
Y
N
L
S
A
L
G
R
S
V
---
V
A
H
V
R
A
L
A
--------------------------------------------------------------------------------------------------------------------