@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ08_V3_1300: (2017-09-12 )
MTMPKRQRSDEKAAHHVQLSVESGSRFDAYIRGWMQGTVEQPLLRPSLLPPLTPLPTLAAPSKSGAAQTPATASAATTVGDLSRLCEWTPPSAVMPASRTAVVYDTSMLDHVSPDAGDYERPARLQSTLDHLTVIGLLPCCQRIPARTAKKHELRRVHCRELIDTVDQLDFFMGIQEGRGSVIGQDLFASEHTSRAARMAAGCVIEAVKAVLSGAATNAFAIVRPPGHHAGPANAAGYCLYNNVAVAARAAQAELAAAQAEHNPAGDAQQPRILILDWDVHHCDGTESIFYDDPSVLVISLHQYGNGHGHVLRKVSSAAAKNPAEISTPSKEAITADDLAALLSGGAIEPPPVSAPEASRPEAASDPPQGSTEGRRVRAAVDYNSLAAQIEEEGDAEIAALFGVDLNAASTSSSNSSSASTSSSVSADSTSVARNGTRPVHYAGDTVGVSFDETPRQRATGAEEEELFYPGTGHLNRVGGDATPAAQGRNINIPWPTHGMGDLEYLQLLHEVVLPAAREFRPELVLISCGFDSASGDLLGSMCLTPSGYYIMTRLMAQNFPKLVVALEGGYNVRNVALCSEAVMRALLESSGCPGDRLPKSRMLWCQASSLVADIKRMHAPYWSCFSPNM
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110..---------------.----------------.---------------....120.......130.......140.....-----..150.......160.......170..-..---------.--------------.-.180.......-190.......200.......210.......220....-.--..230.......240.......250.......260.......270.......280.......290.......300..-------------------.....-----------------------------------------------------------------310...----------------....320.....-------------..330..-----.....------340......-.350......------------------------------------.360.......370.......380-----------........390.......400----.......410.......420.......430.....---..440......-...450.......460....------...-------470.--..------------...----------..480..--------------.....490......---.500.......510.......520.......530.....--..540...-----....550.-......----560.-----.......570.......580.......590.......600---------------.---.-.......-610.......620.......630------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTMPKRQRSDEKA
A
H
H
V
Q
L
S
VESGS
R
F
D
A
Y
I
R
G
W
M
QGTVEQPLLRPSLLPPLTPLPTLAAPSKSGAAQTPATAS
A
A
T
T
V
G
D
L
S
R
LCEWTPPSAVMPAS
R
T
A
V
V
Y
DT
S
M
L
D-HVS---------------P----------------D---------------AGDYE
R
P
A
R
L
Q
S
T
L
D
H
L
T
V
I
G
L
L
P
C
C
Q
RIPAR-----T
A
K
K
H
E
L
R
R
V
H
C
R
E
L
I
D
T
V
D
Q
L
D
F
F
M
G
-
I
Q---------E--------------G-RGSVI
G
Q
D
L
FA-SE
H
T
S
R
A
A
R
M
A
A
G
C
V
I
E
A
V
K
A
V
L
SGAAT
N
A
F
A
I
VRPP-G--HHAGPANA
A
G
Y
C
L
YNNV
A
V
A
A
R
A
A
Q
A
E
L
A
A
A
QAEHNPAGDAQQ
P
R
I
L
I
L
DWDVHHCDGTESIFYDDP
S
V
L
V
I
S
L
HQY-------------------GNG
H
G
-----------------------------------------------------------------
H
V
L
R
K
V
----------------
S
S
AAAKNPAEIS-------------TPSKEAI-----
T
A
D
D
L
------
A
A
L
L
SGGAI-EPPPVSAPEA------------------------------------SRPEAASDPPQGSTEG
R
R
V
R
A
A
V------------
D
Y
N
S
L
A
A
Q
I
EEEGDA
E
I
A
A
L
F
----
G
V
DLNAASTSSSNSSSASTSSSVSADSTSVARNGT---R
P
V
--
H
YAG
D
T
-VGVSFDETPRQRATGAEEE
E
------
L
FY-------PG-T--GH------------LNR----------VGGDATP--------------AAQGRNINIPWPTH---GMG
D
L
E
Y
L
Q
L
L
H
E
V
VL
P
A
A
R
EFRP
E
L
V
L
I
SCGFDSASGD--
L
L
GSMCLT-----PS
G
Y
Y
I
M
T
-
R
L
M
A
QN----F-
P
K
-----
L
V
V
A
LEGGYNV
R
N
V
A
L
C
S
E
A
V
M
R
A
L
L
ESSGCPGDRLPK-----------------S---
R
-
M
L
W
C
Q
A
S
-
S
L
V
A
D
I
K
R
MHAPYWSCFSPNM--------
192
HHSearch
76.05
35%
-102
- C2 -
-
5JI5
6
?
A:
[10-314]
--------------------------------------------------------------------------------------------------
A
T
G
F
Y
S
H
A
D
C
L
Q
-
H
E
M
---------------
G
--------------------------------
Q
W
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
S
R
I
G
E
L
I
E
R
E
S
A
P
-----
L
A
D
E
A
A
L
L
R
V
H
T
K
A
H
V
D
Y
L
R
A
R
S
P
Q
S
------------------------------
G
Y
A
E
I
D
P
D
T
S
M
-
N
P
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
G
R
Y
D
N
A
F
C
S
V
R
P
P
-
G
--
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
V
-
H
------------
K
L
E
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
Q
H
-------------------
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
-------
P
F
-
T
--
G
A
------------
D
---------------------------------
N
Q
A
P
N
M
C
N
V
P
I
A
A
R
---
S
-
K
G
M
V
V
R
E
A
I
D
M
I
W
L
P
R
L
D
A
F
K
P
Q
M
L
F
V
S
A
G
F
D
A
H
R
E
D
--
D
L
G
N
M
A
L
V
-----
E
D
D
Y
A
W
I
T
-
Q
Q
I
R
L
V
A
D
K
Y
A
K
G
R
-----
I
V
S
C
L
E
G
G
Y
N
L
S
A
L
G
R
S
V
V
A
H
V
R
A
L
A
D
-----------------------------------------------------------------------
186
HHSearch
74.91
38%
-48
- C2 -
-
5G0Y
3
HDAH_PSEAE
B:
[2-334]
-------------------------------------------------------------------------------------------------
R
R
T
A
F
F
F
D
E
L
C
L
W
-
H
A
A
---------------
G
PHALTLPVGGWVQPPA
A
---------------
A
G
H
A
E
S
P
E
T
K
R
R
L
K
S
L
L
D
V
S
G
L
T
A
R
L
Q
L
R
S
A
P
-----
P
A
S
D
E
D
L
L
R
V
H
P
A
H
Y
L
E
R
F
K
A
L
S
D
A
G
-------------------------------
G
G
S
L
G
Q
D
A
P
I
-
G
P
G
S
Y
E
I
A
R
L
S
A
G
L
A
I
A
A
L
D
A
V
L
A
G
E
A
D
N
A
Y
S
L
S
R
P
P
-
G
--
H
H
C
L
P
D
Q
A
M
G
F
C
F
F
A
N
I
A
V
A
I
E
A
A
K
A
R
-
H
------------
G
V
E
R
V
A
V
L
D
W
D
V
H
H
G
N
G
T
Q
A
I
Y
Y
R
R
D
D
V
L
S
I
S
L
H
Q
D
-------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
F
P
-------
P
G
-
Y
--
S
G
------------
A
E
D
----------
I
G
E
D
-----------------
R
G
R
G
F
N
L
N
V
P
L
L
P
G
----
G
G
H
D
A
Y
M
Q
A
M
Q
R
I
V
L
P
A
L
E
R
F
R
P
Q
L
I
V
V
A
S
G
F
D
A
N
A
V
D
--
P
L
A
R
M
Q
L
H
-----
S
D
S
F
R
A
M
T
-
A
M
V
R
D
A
AERH
A
G
G
R
-----
L
V
V
V
H
E
G
G
Y
S
E
A
Y
V
P
F
C
G
L
A
V
I
E
E
L
S
G
V
R
S
A
-------------------------------------------------------------------
185
HHSearch
74.36
38%
-49
- C2 -
-
5G0X
7
HDAH_PSEAE
A:
[2-334]
-------------------------------------------------------------------------------------------------
R
R
T
A
F
F
F
D
E
L
C
L
W
-
H
A
A
---------------
G
P
HALTLPVGGWVQPPA
A
---------------
A
G
H
A
E
S
P
E
T
K
R
R
L
K
S
L
L
D
V
S
G
L
T
A
R
L
Q
L
R
S
A
P
-----
P
A
S
D
E
D
L
L
R
V
H
P
A
H
Y
L
E
R
F
K
A
L
S
D
A
G
-------------------------------
G
G
S
L
G
Q
D
A
P
I
-
G
P
G
S
Y
E
I
A
R
L
S
A
G
L
A
I
A
A
L
D
A
V
L
A
G
E
A
D
N
A
Y
S
L
S
R
P
P
-
G
--
H
H
C
L
P
D
Q
A
M
G
F
C
F
F
A
N
I
A
V
A
I
E
A
A
K
A
R
-
H
------------
G
V
E
R
V
A
V
L
D
W
D
V
H
H
G
N
G
T
Q
A
I
Y
Y
R
R
D
D
V
L
S
I
S
L
H
Q
D
-------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
F
P
-------
P
G
-
Y
--
S
G
------------
A
E
D
----------
I
G
E
D
-----------------
R
G
R
G
F
N
L
N
V
P
L
L
P
G
----
G
G
H
D
A
Y
M
Q
A
M
Q
R
I
V
L
P
A
L
E
R
F
R
P
Q
L
I
V
V
A
S
G
F
D
A
N
A
V
D
--
P
L
A
R
M
Q
L
H
-----
S
D
S
F
R
A
M
T
-
A
M
V
R
D
A
A
E
R
H
A
G
G
R
-----
L
V
V
V
H
E
G
G
Y
S
E
A
Y
V
P
F
C
G
L
A
V
I
E
E
L
S
G
V
R
S
A
-------------------------------------------------------------------
179
HHSearch
74.03
38%
-41
- C2 -
-
5EEI
12
?
A:
[8-364]
-------------------------------------------------------------------------------------------------
P
I
T
G
L
V
Y
D
Q
R
M
M
L
-
H
H
N
---------------
M
W---------------
D
---------------
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
-----
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
I
K
S
S
E
H
M
K
P
-
R
D
---------
L
--------------
N
-
R
L
G
D
E
Y
N
S
I
F
I
-
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
-
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
------------
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
-------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
------
A
F
F
-------
P
N
-
S
--
E
D
AN----------
Y
D
K
----------
V
G
L
G
-----------------
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
V
T
-----
P
E
G
Y
A
H
L
T
-
H
Q
L
M
S
L
----
A
A
G
R
-----
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
---
L
D
H
-----------------
L
---
T
-
P
L
K
T
S
A
T
-
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------
180
HHSearch
73.91
38%
-41
- C2 -
-
5EFG
4
?
A:
[7-364]
------------------------------------------------------------------------------------------------
S
P
I
T
G
L
V
Y
D
Q
R
M
M
L
-
H
H
N
---------------
M
W---------------
D
---------------
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
-----
L
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
S
I
I
K
S
S
E
H
M
K
P
-
R
D
---------
L
--------------
N
-
R
L
G
D
E
Y
N
S
I
F
I
-
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
I
V
R
P
P
-
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
R
------------
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
R
Y
-------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
------
A
F
F
-------
P
N
-
S
--
E
D
AN----------
Y
D
K
----------
V
G
L
G
-----------------
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
V
T
-----
P
E
G
Y
A
H
L
T
-
H
Q
L
M
S
L
----
A
A
G
R
-----
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
---
L
D
H
-----------------
L
---
T
-
P
L
K
T
S
A
T
-
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
-----------
176
HHSearch
70.31
37%
-26
- C2 -
-
2VQJ
9
A:
[6-390]
-----------------------------------------------------------------------------------------------
P
R
F
T
T
G
L
V
Y
D
T
L
M
L
K
-
H
Q
C
---------------
T
CGS-------------
S
---------------
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
-----
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
L
N
R
Q
K
L
D
S--------
K
K
L
L
G
S
L
A
S
V
F
VRLP
C
-
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
-
G
--
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
-
L
------------
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
-------------------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
------
N
F
F
-------
P
G
-
S
--
G
A
------------
P
D
E
----------
V
G
T
G
-----------------
P
G
V
G
F
N
V
N
M
A
F
T
G
G
LDP
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
PT
P
L
G
G
Y
N
L
S
-----
A
R
C
F
G
Y
L
T
-
K
Q
L
M
G
L
----
A
G
G
R
-----
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
---
L
P
E
-----------------
K
V
L
Q
Q
-
R
P
N
A
N
A
V
-
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
---------
190
HHSearch
69.82
29%
-47
- C2 -
-
5G1A
10
HDAH_ALCSD
A:
[3-369]
-------------------------------------------------------------------------------------------------
H
A
I
G
Y
V
W
N
T
L
Y
G
W
-
V
D
T
---------------
G
----------------
T
GSLAAANLTARMQPI
S
H
H
L
A
H
P
D
T
K
R
R
F
H
E
L
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
-----
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
L
E
N
M
K
R
V
S
N
L
P
T
-----------------------------
G
G
D
T
G
D
G
I
T
M
M
-
G
N
G
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
-
G
--
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
-
L
------------
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
H
-------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
F
P
-------
P
D
-
S
--
G
Y
------------
S
T
E
----------
R
G
A
G
-----------------
N
G
H
G
Y
N
I
N
V
P
L
P
P
G
----
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
S
M
L
D
--
P
L
A
R
M
M
V
T
-----
A
D
G
F
R
Q
M
A
-
R
R
T
I
D
C
A
A
D
I
C
D
G
R
-----
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
L
P
---
D
P
Y
-----------------
H
---
E
F
L
A
G
M
G
G
N
-
T
L
L
D
A
E
R
A
A
I
E
-
I
V
P
L
L
A
D
----------
178
HHSearch
69.47
34%
0
- C- -
-
5TD7
11
?
A:
[3-413]
-----------------------------------------------------------------------------------------------
A
A
S
G
S
A
L
I
F
D
E
E
M
S
R
-
Y
K
L
---------------
L
----------------
W
TDP------------
A
C
E
I
E
V
P
E
R
L
T
V
S
Y
E
A
L
R
T
H
G
L
A
Q
R
C
K
A
V
P
V
R
-----
Q
A
T
E
Q
E
I
L
L
A
H
S
E
E
Y
L
E
A
V
K
Q
T
P
G
M
N
V
-
E
E
---------
L
--------------
M
-
A
F
S
K
K
Y
N
D
V
Y
F
-
H
Q
N
I
Y
H
C
A
K
L
A
A
G
A
T
L
Q
L
V
D
S
V
M
K
R
E
V
R
N
G
M
A
L
V
R
P
P
-
G
--
H
H
S
Q
R
S
A
A
N
G
F
C
V
F
N
N
V
A
F
A
A
L
Y
A
K
K
N
-
Y
------------
N
L
N
R
I
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
C
F
E
E
D
P
S
V
L
Y
F
S
W
H
R
Y
-------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
------
S
F
W
-------
P
N
-
L
PE
S
D
------------
Y
S
S
----------
V
G
K
G
-----------------
K
G
S
G
F
N
I
N
L
P
W
N
K
V
---
G
M
T
N
S
D
Y
L
A
A
F
F
H
V
L
L
P
V
A
Y
E
F
D
P
E
L
V
I
V
S
A
G
F
D
S
A
I
G
D
--
P
E
G
E
M
C
A
L
-----
P
E
I
F
A
H
L
T
-
H
L
L
M
P
L
----
A
A
G
K
-----
M
C
V
V
L
E
G
G
F
N
L
T
S
L
G
Q
S
V
C
Q
T
V
H
S
L
L
G
D
P
T
P
R
---
I
S
G
-----------------
L
---
G
-
T
A
C
D
S
A
L
-
E
S
I
Q
N
V
R
N
V
Q
S
S
Y
W
S
S
F
K
H
----------
203
Fugue
68.47
34%
-15
- C1 -
-
5G0J
9
?
A:
[17-772]
--------------------
V
Q
G
K
S
K
----------------------------------------------------------------------
A
T
G
T
G
L
V
Y
V
D
A
F
T
R
F
H
C
L
---------------
W
----------------
D
---------------
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
E
G
L
L
G
R
C
V
Q
V
E
A
R
-----
A
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
T
E
-
E
E
---------
L
--------------
K
-
T
L
A
E
K
Y
D
S
V
Y
L
-
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
F
S
I
N
R
P
P
-
G
--
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
H
-------------
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
EDGSFWPHLKESDSSSVGS
G
A
G
Q
G
Y
N
I
N
L
P
W
NKVGME
S
G
D
Y
I
T
A
F
Q
QL
L
L
P
V
A
Y
E
F
QPQ
L
V
L
V
AAGFDAVIGDPKGG
M
Q
V
S
P
E
C
F
S
I
L
T
H
M
L
K
G
V
A
Q
GR
L
V
L
A
L
E
G
GYN
L
Q
S
T
A
E
G
V
C
A
S
M
R
S
L
L
GDPCPHLPSSG
A
P
C
E
S
A
L
K
S
I
S
K
T
I
S
D
L
YPFWKS
L
Q
T
F
E
G
G
P
L
S
E
V
S
P
L
P
A
P
V
C
A
E
VKVSS
P
I
T
G
L
V
Y
D
QRMMLHHNMWDSHHPELPQ
R
I
S
R
I
F
S
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
A
R
L
A
T
E
E
E
L
A
L
CHS
S
K
H
I
S
I
I
K
S
S
E
H
M
K
P
R
D
L
N
R
L
G
D
EYN
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
G
Q
V
R
N
A
V
A
IV
R
P
P
GH
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T
RES
L
R
V
L
I
V
D
WDVHHG
N
G
-
T
--
Q
H
I
F
EEDDS
V
L
Y
I
S
L
H
R
----------
Y
E
D
G
A
F
F
PNSEDANYDKVGLG
K
G
R
G
Y
N
V
N
I
P
W
N
G
G
---
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
M
P
I
A
R
E
F
A
P
E
L
V
L
V
S
A
G
F
D
A
A
R
G
D
--
P
L
G
G
F
Q
V
T
-----
P
E
G
Y
A
H
L
T
H
Q
L
M
S
L
A
----
A
-
G
R
-----
V
L
I
I
L
E
G
G
Y
N
L
T
S
I
S
E
S
M
S
M
C
T
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
P
------------------------
L
K
T
S
A
T
-
V
S
I
N
N
V
L
R
A
H
A
P
F
W
S
S
L
R
V
N
I
PESLRLSL
191
HHSearch
67.66
29%
-43
- C2 -
-
5G1B
7
HDAH_ALCSD
A:
[3-369]
-------------------------------------------------------------------------------------------------
H
A
I
G
Y
V
W
N
T
L
Y
G
W
-
V
D
T
---------------
G
----------------
T
GSLAAANLTARMQPI
S
H
H
L
A
H
P
D
T
K
R
R
F
H
E
L
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
-----
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
L
E
N
M
K
R
V
S
N
L
P
T
-----------------------------
G
G
D
T
G
D
G
I
T
M
M
-
G
N
G
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
-
G
--
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
-
L
------------
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
H
-------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
F
P
-------
P
D
-
S
--
G
Y
------------
S
T
E
----------
R
G
A
G
-----------------
N
G
H
G
Y
N
I
N
V
P
L
P
P
G
----
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
S
M
L
D
--
P
L
A
R
M
M
V
T
-----
A
D
G
F
R
Q
M
A
-
R
R
T
I
D
C
A
A
D
I
C
D
G
R
-----
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
L
P
---
D
P
Y
-----------------
H
---
E
F
L
A
G
M
G
G
N
-
T
L
L
D
A
E
R
A
A
I
E
E
I
V
P
L
L
A
D
----------
200
Fugue
65.69
29%
-39
- C2 -
-
1ZZ1
5
HDAH_ALCSD
A:
[2-368]
--------------------------------------------------------------------------------------------------
A
I
G
Y
V
W
N
T
L
Y
G
W
-
V
D
T
GTGSLAAANLTARMQ
P
----------------
I
---------------
S
H
H
L
A
H
P
D
T
K
R
R
F
H
E
L
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
-----
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
L
E
N
M
K
R
V
S
N
-----
L
---------
P
--------------
T
-
G
G
D
T
G
D
G
I
T
M
M
-
G
N
G
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
-
G
--
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
-------------
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
H
-------------------
L
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-------
P
D
-
S
--
G
Y
------------
S
T
E
----------
R
G
A
G
-----------------
N
G
H
G
Y
N
I
N
V
P
L
P
P
----
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
S
M
L
D
--
P
L
A
R
M
M
V
T
-----
A
D
G
F
R
Q
M
A
-
R
R
T
I
D
C
----
A
-
A
D
ICDGR
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
L
P
D
P
Y
H
E
F
-----------------
L
---
A
-
G
M
G
G
N
T
L
L
D
A
E
R
A
A
I
E
E
I
V
P
L
L
A
D
I
------------
197
HHSearch
62.96
22%
-80
- C2 -
-
4BZ5
4
?
B:
[2-366]
--------------------------------------------------------------------------------------------------
S
V
G
I
V
Y
G
D
Q
Y
R
Q
-
L
C
C
-------------------------------------------------
S
S
P
K
F
G
D
R
Y
A
L
V
M
D
L
I
N
A
Y
K
L
I
P
E
L
S
R
V
P
P
L
QWDS
P
S
R
M
Y
E
A
V
T
A
F
H
S
T
E
Y
V
D
A
L
K
K
L
Q
M
L
H
C
-
E
E
K
E
L
T
A
D
D
E
L
L
--------------
M
-
D
S
F
S
L
N
Y
D
C
P
G
-
F
P
S
V
F
D
Y
S
L
A
A
V
Q
G
S
L
A
A
A
S
A
L
I
C
R
H
C
---
E
V
V
I
N
W
G
-
G
GW
H
H
A
K
R
S
E
A
S
G
F
C
Y
L
N
D
I
V
L
A
I
H
R
L
V
S
S
-
T
-------------
Q
T
R
V
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
E
A
F
W
Y
S
P
R
V
V
T
F
S
V
H
H
A
-------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------
G
F
F
-------
P
G
-
T
--
G
T
------------
W
N
M
V
DNDKL
P
I
F
L
N
G
A
G
-----------------
R
G
R
F
S
A
F
N
L
P
L
E
E
G
----
I
N
D
L
D
W
S
N
A
I
G
P
I
L
D
S
L
N
I
V
I
Q
P
S
Y
V
V
V
Q
C
G
A
D
C
L
A
T
D
--
P
H
R
I
F
R
L
T
NFYPS
L
S
G
Y
L
Y
A
I
-
K
K
I
L
S
W
----
K
-
V
P
-----
T
L
I
L
G
G
G
G
Y
N
F
P
D
T
A
R
L
W
T
R
V
T
A
L
T
I
E
E
----------------------------------------------------------------------
189
HHSearch
61.00
21%
-41
- C2 -
-
5DC8
4
HDAC8_HUMAN
A:
[14-376]
-------------------------------------------------------------------------------------------------
L
V
P
V
Y
I
Y
S
P
E
Y
V
S
-
M
C
-------------------------------------------------
D
S
L
A
K
I
P
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
H
K
Q
M
R
I
V
K
P
K
-----
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
S
Q
E
G
D
-
D
D
HP-------
D
--------------
S
-
I
E
Y
G
L
G
Y
D
C
P
A
-
T
E
G
I
F
D
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
N
W
-
S
G
G
-
W
--
A
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---------------
K
F
E
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
-------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------
G
F
F
-------
P
G
-
T
--
G
D
------------
V
S
D
----------
V
G
L
G
-----------------
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
--
P
M
C
S
F
N
M
T
-----
P
V
G
I
G
K
C
L
-
K
Y
I
L
Q
W
----
Q
-
L
A
-----
T
L
I
L
G
G
G
G
F
N
L
A
N
T
A
R
C
W
T
Y
L
T
G
V
I
L
G
K
T
L
S
S
--
E
I
P
D
HEFFTAYGPDYVL
E
I
T
P
S
---
C
-
R
P
D
R
N
E
P
-
H
R
I
Q
Q
I
L
N
Y
I
K
G
N
L
K
H
V
------------
182
HHSearch
60.10
24%
-36
* C2 *
-
5IWG
7
HDAC2_HUMAN
A:
[2-367]
------------------------------------------------------------------------------------------------
K
K
K
V
C
Y
Y
Y
D
G
D
I
G
N
-
Y
Y
Y
---------------
G
--------------------------------
Q
G
H
P
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Y
G
L
Y
R
K
M
E
I
Y
R
P
H
-----
K
A
T
A
E
E
M
T
K
Y
H
S
D
E
Y
I
K
F
L
R
S
I
R
P
D
N
M
-
S
E
Y
S
K
------
Q
--------------
M
-
Q
R
F
N
V
G
E
D
C
P
V
-
F
D
G
L
F
E
F
C
Q
L
S
T
G
G
S
V
A
G
A
V
K
L
N
R
Q
Q
--
T
D
M
A
V
N
W
A
G
-
G
L-
H
H
A
K
K
S
E
A
S
G
F
C
Y
V
N
D
I
V
L
A
I
L
E
L
L
K
---------------
Y
H
Q
R
V
L
Y
I
D
I
D
I
H
H
G
D
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
S
F
H
K
Y
-------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
F
-------
P
G
-
T
--
G
D
------------
L
R
D
----------
I
G
A
G
-----------------
K
G
K
Y
Y
A
V
N
F
P
M
R
D
G
----
I
D
D
E
S
Y
G
Q
I
F
K
P
I
I
S
K
V
M
E
M
Y
Q
P
S
A
V
V
L
Q
C
G
A
D
S
L
S
G
D
--
R
L
G
C
F
N
L
T
-----
V
K
G
H
A
K
C
V
-
E
V
V
K
T
F
----
N
-
L
P
-----
L
L
M
L
G
G
G
G
Y
T
I
R
N
V
A
R
C
W
T
Y
E
T
A
V
A
L
D
C
E
I
P
N
--
E
L
P
Y
NDYFEYFGPDFKL
H
I
S
P
S
---
N
-
M
T
N
Q
N
T
P
-
E
Y
M
E
K
I
K
Q
R
L
F
E
N
L
R
M
L
------------
194
HHSearch
58.50
27%
-16
- C2 -
-
1C3R
3
?
A:
[2-320]
-------------------------------------------------------------------------------------------------
K
K
V
K
L
I
G
T
L
D
Y
G
K
-
Y
R
Y
---------------
P
--------------------------------
K
N
H
P
L
K
I
P
R
V
S
L
L
L
R
F
K
D
A
M
N
L
I
D
E
K
E
L
I
K
S
R
-----
P
A
T
K
E
E
L
L
L
F
H
T
E
D
Y
I
N
T
L
M
E
A
E
R
S
Q
S
-
V
P
---------
K
G
A
------------
R
E
K
Y
N
I
G
G
Y
E
N
P
V
-
S
Y
A
M
F
T
G
S
S
L
A
T
G
S
T
V
Q
A
I
E
E
F
L
K
G
N
--
V
A
---
F
N
P
A
-
G
GM
H
H
A
F
K
S
R
A
N
G
F
C
Y
I
N
N
P
A
V
G
I
E
Y
L
R
K
K
--------------
G
F
K
R
I
L
Y
I
D
L
D
A
H
H
C
D
G
V
Q
E
A
F
Y
D
T
D
Q
V
F
V
L
S
L
H
Q
S
-------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------
Y
A
F
-------
P
F
E
K
--
G
F
------------
L
E
E
----------
I
G
E
G
-----------------
K
G
K
G
Y
N
L
N
I
P
L
P
K
G
----
L
N
D
N
E
F
L
F
A
L
E
K
S
L
E
I
V
K
E
V
F
E
P
E
V
Y
L
L
Q
L
G
T
D
P
L
L
E
D
--
Y
L
S
K
F
N
L
S
-----
N
V
A
F
L
K
A
F
-
N
I
V
R
E
V
----
F
-
G
E
-----
G
V
Y
L
G
G
G
G
Y
H
P
Y
A
L
A
R
A
W
T
L
I
W
C
E
L
S
G
R
E
V
P
E
------------------------------------------------------------------
193
HHSearch
58.03
27%
-13
- C2 -
-
1C3P
-
?
A:
[2-320]
-------------------------------------------------------------------------------------------------
K
K
V
K
L
I
G
T
L
D
Y
G
K
-
Y
R
Y
---------------
P
--------------------------------
K
N
H
P
L
K
I
P
R
V
S
L
L
L
R
F
K
D
A
M
N
L
I
D
E
K
E
L
I
K
S
R
-----
P
A
T
K
E
E
L
L
L
F
H
T
E
D
Y
I
N
T
L
M
E
A
E
R
C
Q
C
-
V
P
KGA------
R
--------------
E
-
K
Y
N
I
G
G
Y
E
N
P
V
-
S
Y
A
M
F
T
G
S
S
L
A
T
G
S
T
V
Q
A
I
E
E
F
L
K
G
N
--
V
A
---
F
N
P
A
-
G
GM
H
H
A
F
K
S
R
A
N
G
F
C
Y
I
N
N
P
A
V
G
I
E
Y
L
R
K
K
--------------
G
F
K
R
I
L
Y
I
D
L
D
A
H
H
C
D
G
V
Q
E
A
F
Y
D
T
D
Q
V
F
V
L
S
L
H
Q
S
-------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------
Y
A
F
-------
P
F
E
K
--
G
F
------------
L
E
E
----------
I
G
E
G
-----------------
K
G
K
G
Y
N
L
N
I
P
L
P
K
G
----
L
N
D
N
E
F
L
F
A
L
E
K
S
L
E
I
V
K
E
V
F
E
P
E
V
Y
L
L
Q
L
G
T
D
P
L
L
E
D
--
Y
L
S
K
F
N
L
S
-----
N
V
A
F
L
K
A
F
-
N
I
V
R
E
V
----
F
-
G
E
-----
G
V
Y
L
G
G
G
G
Y
H
P
Y
A
L
A
R
A
W
T
L
I
W
C
E
L
S
G
R
E
V
P
E
------------------------------------------------------------------
184
HHSearch
57.94
23%
-39
- C2 -
-
5ICN
4
HDAC1_HUMAN
B:
[8-375]
------------------------------------------------------------------------------------------------
R
R
K
V
C
Y
Y
Y
D
G
D
V
G
N
-
Y
Y
Y
---------------
G
--------------------------------
Q
G
H
P
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Y
G
L
Y
R
K
M
E
I
Y
R
P
H
-----
K
A
N
A
E
E
M
T
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
R
P
D
N
M
-
S
E
Y
S
K
------
Q
--------------
M
-
Q
R
F
N
V
G
E
D
C
P
V
-
F
D
G
L
F
E
F
C
Q
L
S
T
G
G
S
V
A
S
A
V
K
L
N
K
Q
Q
--
T
D
I
A
V
N
W
A
G
G
L
--
H
H
A
K
K
S
E
A
S
G
F
C
Y
V
N
D
I
V
L
A
I
L
E
L
L
K
---------------
Y
H
Q
R
V
L
Y
I
D
I
D
I
H
H
G
D
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
S
F
H
K
Y
-------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
F
-------
P
G
-
T
--
G
D
------------
L
R
D
----------
I
G
A
G
-----------------
K
G
K
Y
Y
A
V
N
Y
P
L
R
D
G
----
I
D
D
E
S
Y
E
A
I
F
K
P
V
M
S
K
V
M
E
M
F
Q
P
S
A
V
V
L
Q
C
G
S
D
S
L
S
G
D
--
R
L
G
C
F
N
L
T
-----
I
K
G
H
A
K
C
V
-
E
F
V
K
S
F
----
N
-
L
P
-----
M
L
M
L
G
G
G
G
Y
T
I
R
N
V
A
R
C
W
T
Y
E
T
A
V
A
L
D
T
E
I
P
N
--
E
L
P
Y
NDYFEYFGPDFKL
H
I
S
P
S
---
N
-
M
T
N
Q
N
T
N
-
E
Y
L
E
K
I
K
Q
R
L
F
E
N
L
R
M
L
P
H
----------
183
HHSearch
57.77
24%
-34
- C2 -
-
4LY1
10
HDAC2_HUMAN
B:
[2-368]
------------------------------------------------------------------------------------------------
K
K
K
V
C
Y
Y
Y
D
G
D
I
G
N
-
Y
Y
Y
---------------
G
--------------------------------
Q
G
H
P
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Y
G
L
Y
R
K
M
E
I
Y
R
P
H
-----
K
A
T
A
E
E
M
T
K
Y
H
S
D
E
Y
I
K
F
L
R
S
I
R
P
D
N
M
-
S
E
Y
S
K
------
Q
--------------
M
-
Q
R
F
N
V
G
E
D
C
P
V
-
F
D
G
L
F
E
F
C
Q
L
S
T
G
G
S
V
A
G
A
V
K
L
N
R
Q
Q
--
T
D
M
A
V
N
W
A
G
-
G
L-
H
H
A
K
K
S
E
A
S
G
F
C
Y
V
N
D
I
V
L
A
I
L
E
L
L
K
---------------
Y
H
Q
R
V
L
Y
I
D
I
D
I
H
H
G
D
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
S
F
H
K
Y
-------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
F
-------
P
G
-
T
--
G
D
------------
L
R
D
----------
I
G
A
G
-----------------
K
G
K
Y
Y
A
V
N
F
P
M
R
D
G
----
I
D
D
E
S
Y
G
Q
I
F
K
P
I
I
S
K
V
M
E
M
Y
Q
P
S
A
V
V
L
Q
C
G
A
D
S
L
S
G
D
--
R
L
G
C
F
N
L
T
-----
V
K
G
H
A
K
C
V
-
E
V
V
K
T
F
----
N
-
L
P
-----
L
L
M
L
G
G
G
G
Y
T
I
R
N
V
A
R
C
W
T
Y
E
T
A
V
A
L
D
C
E
I
P
N
--
E
L
P
Y
NDYFEYFGPDFKL
H
I
S
P
S
---
N
-
M
T
N
Q
N
T
P
-
E
Y
M
E
K
I
K
Q
R
L
F
E
N
L
R
M
L
P
-----------
187
HHSearch
57.68
23%
-41
- C2 -
-
4BKX
8
HDAC1_HUMAN
B:
[8-375]
------------------------------------------------------------------------------------------------
R
R
K
V
C
Y
Y
Y
D
G
D
V
G
N
-
Y
Y
Y
---------------
G
--------------------------------
Q
G
H
P
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Y
G
L
Y
R
K
M
E
I
Y
R
P
H
-----
K
A
N
A
E
E
M
T
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
R
P
D
N
M
-
S
E
Y
S
K
------
Q
--------------
M
-
Q
R
F
N
V
G
E
D
C
P
V
-
F
D
G
L
F
E
F
C
Q
L
S
T
G
G
S
V
A
S
A
V
K
L
N
K
Q
Q
--
T
D
I
A
V
N
W
A
G
G
L
--
H
H
A
K
K
S
E
A
S
G
F
C
Y
V
N
D
I
V
L
A
I
L
E
L
L
K
Y
---------------
H
Q
R
V
L
Y
I
D
I
D
I
H
H
G
D
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
S
F
H
K
Y
-------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
F
-------
P
G
-
T
--
G
D
------------
L
R
D
----------
I
G
A
G
-----------------
K
G
K
Y
Y
A
V
N
Y
P
L
R
D
G
----
I
D
D
E
S
Y
E
A
I
F
K
P
V
M
S
K
V
M
E
M
F
Q
P
S
A
V
V
L
Q
C
G
S
D
S
L
S
G
D
--
R
L
G
C
F
N
L
T
-----
I
K
G
H
A
K
C
V
-
E
F
V
K
S
F
----
N
-
L
P
-----
M
L
M
L
G
G
G
G
Y
T
I
R
N
V
A
R
C
W
T
Y
E
T
A
V
A
L
D
T
E
I
P
N
--
E
L
P
Y
NDYFEYFGPDFKL
H
I
S
P
S
---
N
-
M
T
N
Q
N
T
N
-
E
Y
L
E
K
I
K
Q
R
L
F
E
N
L
R
M
L
P
H
----------
188
HHSearch
55.93
22%
-40
- C2 -
-
1T64
6
HDAC8_HUMAN
B:
[14-376]
-------------------------------------------------------------------------------------------------
L
V
P
V
Y
I
Y
S
P
E
Y
V
S
-
M
C
-------------------------------------------------
D
S
L
A
K
I
P
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
H
K
Q
M
R
I
V
K
P
K
-----
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
S
Q
E
G
D
-
D
D
HP-------
D
--------------
S
-
I
E
Y
G
L
G
Y
D
C
P
A
-
T
E
G
I
F
D
Y
A
A
A
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G
G
A
T
I
T
A
A
Q
C
L
I
D
G
M
C
K
V
A
I
N
W
-
S
G
G
-
W
--
H
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
---------------
K
F
E
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
K
F
-------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------
G
F
F
-------
P
G
-
T
--
G
D
------------
V
S
D
----------
V
G
L
G
-----------------
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
G
----
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
V
V
L
Q
L
G
A
D
T
I
A
G
D
--
P
M
C
S
F
N
M
T
-----
P
V
G
I
G
K
C
L
-
K
Y
I
L
Q
W
----
Q
-
L
A
-----
T
L
I
L
G
G
G
G
Y
N
L
A
N
T
A
R
C
W
T
Y
L
T
G
V
I
L
G
K
T
L
S
S
--
E
I
P
D
HEFFTAYGPDYVLEITP
S
---
C
-
R
P
D
R
N
E
P
-
H
R
I
Q
Q
I
L
N
Y
I
K
G
N
L
K
H
V
------------