@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0340: (2017-12-20 )
MIAVKTCGKLYWAGEYAILEPGQLALIKDIPIYMRAEIAFSDSYRIYSDMFDFAVDLRPNPDYSLIQETIALMGDFLAVRGQNLRPFSLAIYGKMEREGKKFGLGSSGSVVVLVVKALLALYNLSVDQNLLFKLTSAVLLKRGDNGSMGDLACIAAEDLVLYQSFDRQKVAAWLEEENLATVLERDWGFSISQVKPTLECDFLVGWTKEVAVSSHMVQQIKQNINQNFLTSSKETVVSLVEALEQGKSEKIIEQVEVASKLLEGLSTDIYTPLLRQLKEASQDLQAVAKSSGAGGGDCGIALSFDAQSTKTLKNRWADLGIELLYQERIGHDDKS
Atome Classification :
(20 SA)
----.........10....------....20........30........40........50.----.------.------.------.---------.------.---.-------60-.-..-----------------------..-----------...70........--80........90....----....100.......110.......120...------------.---------------...130.......140........150.....--.-.160.......170.......180........----190..-.....200.......-210...--..----------..220-..------------...------..---..230---.......240..-------.....250.......260..-...----..270----........280.....-..290.......300---.......---310.......320.....------------..330...---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----
M
I
A
V
K
TCG
K
L
Y
WAG
E
------
Y
A
I
LEPG
Q
L
A
L
I
KDI
P
I
Y
M
R
A
E
I
A
FSDS
Y
R
I
Y
S
D
M
F
D
----
F
------
A
------
V
------D---------L------R---P-------NP-
D
-
Y
S
-----------------------
L
I
-----------
Q
E
T
I
A
L
M
G
D
F
L
A
V--RGQNL
R
P
F
S
L
A
I
Y
G
K
M----EREGKKFGLGSSG
S
V
V
V
L
V
V
K
A
L
L
A
L
YNLS------------V---------------
D
Q
N
L
L
F
K
L
T
S
A
V
L
LK-RGDNGSMG
D
L
A
C
I
A
A
E
--
D
-
L
V
L
Y
Q
SF
D
R
Q
K
V
A
A
W
L
E
E
E
N
L
A
T
-
V
L
E
RDWGF----SISQV-KP
T
L
EC
D
F
L
VG
W
T
K
E
-
V
A
V
S
S
H
--
M
V
----------
Q
Q
I
---
K
Q
------------
N
I
N
------
Q
N
---FLTS
S
---
K
E
T
V
V
S
L
V
E
A
L
E
-------QG
K
S
E
K
I
I
E
Q
V
E
V
A
S
K
L
L
E
G
-LS
T
----
D
I
Y
T
-----
P
L
L
R
Q
L
K
E
A
S
Q
D
L
Q
A
V
-
A
KSSGAGGGDC
G
I
A
L
---
S
FDAQ
S
T
---
K
T
L
K
N
R
W
A
D
L
G
I
E
L
L
Y
Q
E
------------RIGHDDKS---
36
HHSearch
88.59
100%
-131
- C2 -
-
3GON
2
?
A:
[1-329]
----
M
I
A
V
K
T
C
G
K
L
Y
W
A
G
E
------
Y
A
I
L
E
P
G
Q
L
A
L
I
K
D
I
P
I
Y
M
R
A
E
I
A
F
S
D
S
Y
R
I
Y
S
D
M
F
D
----
F
------
A
------
V
------
D
---------
L
------
R
---
P
-------
N
P
-
D
-
Y
S
-----------------------
L
I
-----------
Q
E
T
I
A
L
M
G
D
F
L
A
V
--
R
G
Q
N
L
R
P
F
S
L
A
I
Y
G
K
M
----
E
R
E
G
K
K
F
G
L
G
S
S
G
S
V
V
V
L
V
V
K
A
L
L
A
L
Y
N
L
S
------------
V
---------------
D
Q
N
L
L
F
K
L
T
S
A
V
L
L
K
-
R
G
D
N
G
S
M
G
D
L
A
C
I
A
A
E
--
D
-
L
V
L
Y
Q
S
F
D
R
Q
K
V
A
A
W
L
E
E
E
N
L
A
T
-
V
L
E
R
D
W
G
F
----
S
I
S
Q
V
-
K
P
T
L
E
C
D
F
L
V
G
W
T
K
E
-
V
A
V
S
S
H
--
M
V
----------
Q
Q
I
---
K
Q
------------
N
I
N
------
Q
N
---
F
L
T
S
S
---
K
E
T
V
V
S
L
V
E
A
L
E
-------
Q
G
K
S
E
K
I
I
E
Q
V
E
V
A
S
K
L
L
E
G
-
L
S
T
----
D
I
Y
T
-----
P
L
L
R
Q
L
K
E
A
S
Q
D
L
Q
A
V
-
A
K
S
S
G
A
G
G
G
D
C
G
I
A
L
---
S
F
D
A
Q
S
T
---
K
T
L
K
N
R
W
A
D
L
G
I
E
L
L
Y
Q
E
------------
R
I
---------
1
PsiBlast_PDB
88.59
100%
-131
- C2 -
-
3GON
2
?
A:
[1-329]
----
M
I
A
V
K
T
C
G
K
L
Y
W
A
G
E
------
Y
A
I
L
E
P
G
Q
L
A
L
I
K
D
I
P
I
Y
M
R
A
E
I
A
F
S
D
S
Y
R
I
Y
S
D
M
F
D
----
F
------
A
------
V
------
D
---------
L
------
R
---
P
-------
N
P
-
D
-
Y
S
-----------------------
L
I
-----------
Q
E
T
I
A
L
M
G
D
F
L
A
V
--
R
G
Q
N
L
R
P
F
S
L
A
I
Y
G
K
M
----
E
R
E
G
K
K
F
G
L
G
S
S
G
S
V
V
V
L
V
V
K
A
L
L
A
L
Y
N
L
S
------------
V
---------------
D
Q
N
L
L
F
K
L
T
S
A
V
L
L
K
-
R
G
D
N
G
S
M
G
D
L
A
C
I
A
A
E
--
D
-
L
V
L
Y
Q
S
F
D
R
Q
K
V
A
A
W
L
E
E
E
N
L
A
T
-
V
L
E
R
D
W
G
F
----
S
I
S
Q
V
-
K
P
T
L
E
C
D
F
L
V
G
W
T
K
E
-
V
A
V
S
S
H
--
M
V
----------
Q
Q
I
---
K
Q
------------
N
I
N
------
Q
N
---
F
L
T
S
S
---
K
E
T
V
V
S
L
V
E
A
L
E
-------
Q
G
K
S
E
K
I
I
E
Q
V
E
V
A
S
K
L
L
E
G
-
L
S
T
----
D
I
Y
T
-----
P
L
L
R
Q
L
K
E
A
S
Q
D
L
Q
A
V
-
A
K
S
S
G
A
G
G
G
D
C
G
I
A
L
---
S
F
D
A
Q
S
T
---
K
T
L
K
N
R
W
A
D
L
G
I
E
L
L
Y
Q
E
------------
R
I
---------
2
PsiBlast_PDB
57.21
29%
-27
- C2 -
-
3K17
1
?
A:
[7-347]
-----
L
Q
V
K
I
P
G
K
L
Y
V
A
G
E
------
Y
A
V
V
E
S
G
H
T
A
I
L
T
A
V
N
R
Y
I
T
L
T
L
E
D
S
E
R
N
E
L
W
I
P
H
Y
E
----
N
------
P
------
V
S
W
P
IG
G
E
---------
L
------
K
---
P
-------
D
G
-
E
H
W
T
-----------------------
F
T
-----------
A
E
A
I
N
I
A
T
T
F
L
K
S
--
E
G
I
E
L
T
P
V
K
M
V
I
E
T
E
L
I---
D
Q
S
G
A
K
Y
G
L
G
S
S
A
A
A
T
V
A
V
I
N
A
L
M
T
K
F
Y
P
E
------------
I
---------------
S
M
L
K
K
F
K
L
A
A
L
S
H
L
V
-
V
Q
G
N
G
S
C
G
D
I
A
S
C
M
Y
G
--
G
-
W
I
A
Y
T
T
F
D
Q
E
W
V
K
H
R
L
A
Y
K
S
L
E
W
-
F
M
K
E
P
W
P
M
L
Q
I
E
T
L
E
E
P
-
V
P
T
----
F
S
V
G
W
T
G
T
-
P
V
S
T
G
K
--
L
V
----------
S
Q
I
H
A
F
K
Q
------------
E
D
S
------
K
N
Y
Q
H
F
L
T
R
N
---
N
E
I
M
K
Q
I
I
Q
A
F
H
-------
T
K
D
E
E
L
L
Y
S
S
I
K
E
N
R
R
I
L
Q
E
-
L
G
T
K
A
GV
N
I
E
T
-----
S
L
L
K
E
L
A
D
S
A
E
N
M
G
G
A
-
G
K
S
S
G
S
G
G
G
D
C
G
I
A
F
---
S
K
T
K
E
L
A
---
E
K
L
V
N
E
W
E
K
L
G
I
K
H
L
--------------------------
41
HHSearch
56.78
30%
-20
- C2 -
-
3K17
1
?
B:
[7-350]
-----
L
Q
V
K
I
P
G
K
L
Y
V
A
G
E
------
Y
A
V
V
E
S
G
H
T
A
I
L
T
A
V
N
R
Y
I
T
L
T
L
E
D
S
E
R
N
E
L
W
I
P
H
Y
E
NPVS
W
PI----
G
------
G
------
E
---------
L
------
K
---
P
-------
D
G
E
H
-
W
T
-----------------------
F
T
-----------
A
E
A
I
N
I
A
T
T
F
L
K
S
--
E
G
I
E
L
T
P
V
K
M
V
I
E
T
E
L
IDQS
G
---
A
K
Y
G
L
G
S
S
A
A
A
T
V
A
V
I
N
A
L
M
T
K
F
Y
P
E
------------
I
---------------
S
M
L
K
K
F
K
L
A
A
L
S
H
L
V
-
V
Q
G
N
G
S
C
G
D
I
A
S
C
M
Y
G
--
G
-
W
I
A
Y
T
T
F
D
Q
E
W
V
K
H
R
L
A
Y
K
S
L
E
W
F
M
K
E
P
W
P
M
L
----
Q
I
E
T
L
-
E
E
-
P
V
P
T
F
S
V
G
W
T
G
T
-
P
V
S
T
G
K
--
L
V
----------
S
Q
I
---
H
A
------------
F
K
Q
EDSKNY
Q
H
---
F
L
T
R
N
---
N
E
I
M
K
Q
I
I
Q
A
F
H
-------
T
K
D
E
E
L
L
Y
S
S
I
K
E
N
R
R
I
L
Q
E
-
L
G
T
KAGV
N
I
E
T
-----
S
L
L
K
E
L
A
D
S
A
E
N
M
G
G
A
-
G
K
S
S
G
S
G
G
G
D
C
G
I
A
F
---
S
K
T
K
E
L
A
---
E
K
L
V
N
E
W
E
K
L
G
I
K
H
L
P
F
H
-----------------------
49
HHSearch
52.50
22%
-85
- C2 -
-
4HAC
-
?
A:
[21-310]
----
M
V
S
C
S
A
P
G
K
I
Y
L
F
G
E
------
H
A
V
V
-
Y
G
E
T
A
I
A
C
A
V
E
L
R
T
R
V
R
A
E
L
N
D
S
--
I
T
I
Q
S
-
Q
----
I
------
G
------
R
------
T
---------
G
------
L
---
D
-------
F
E
-
K
-
H
P
-----------------------
Y
V
-----------
S
A
V
I
E
K
M
R
K
S
I
-------
P
I
N
G
V
F
L
T
V
D
S
D
I
----
P
---
V
G
S
G
L
G
S
S
A
A
V
T
I
A
S
I
G
A
L
N
E
L
F
G
F
G
------------
L
---------------
S
L
Q
E
I
A
K
L
G
H
E
I
E
I
K
-
V
Q
G
A
A
S
P
T
D
T
Y
V
S
T
F
G
--
G
-
V
V
T
I
P
E
R
R
--
K
L
------------------------------
K
-
T
P
D
C
G
I
V
I
G
D
T
G
V
-
F
S
S
T
K
E
--
L
V
----------
A
N
V
---
R
Q
------------
L
R
E
S
Y
P
D
L
I
E
P
---
L
M
T
S
I
---
G
K
I
S
R
I
G
E
Q
L
V
L
-------
S
G
D
Y
A
S
I
G
R
L
M
N
V
N
Q
G
L
L
D
A
-
L
G
------
V
N
I
-----
L
E
L
S
Q
L
I
Y
S
A
R
A
A
G
A
F
G
A
K
I
T
G
A
G
G
G
G
C
M
V
A
L
---
T
A
P
E
-
K
C
---
N
Q
V
A
E
A
V
A
G
A
G
G
K
V
T
I
-------------------------
50
HHSearch
51.65
22%
-86
* C2 *
-
4HAC
-
?
B:
[21-310]
----
M
V
S
C
S
A
P
G
K
I
Y
L
F
G
E
------
H
A
V
V
-
Y
G
E
T
A
I
A
C
A
V
E
L
R
T
R
V
R
A
E
L
N
D
S
--
I
T
I
Q
S
-
Q
----
I
------
G
------
R
------
T
---------
G
------
L
---
D
-------
F
E
-
K
-
H
P
-----------------------
Y
V
-----------
S
A
V
I
E
K
M
R
K
S
I
-------
P
I
N
G
V
F
L
T
V
D
S
D
I
----
P
---
V
G
S
G
L
G
S
S
A
A
V
T
I
A
S
I
G
A
L
N
E
L
F
G
F
G
------------
L
---------------
S
L
Q
E
I
A
K
L
G
H
E
I
E
I
K
-
V
Q
G
A
A
S
P
T
D
T
Y
V
S
T
F
G
--
G
-
V
V
T
I
P
E
R
R
--
K
L
------------------------------
K
-
T
P
D
C
G
I
V
I
G
D
T
G
V
-
F
S
S
T
K
E
--
L
V
----------
A
N
V
---
R
Q
------------
L
R
E
S
Y
P
D
L
I
E
P
---
L
M
T
S
I
---
G
K
I
S
R
I
G
E
Q
L
V
L
-------
S
G
D
Y
A
S
I
G
R
L
M
N
V
N
Q
G
L
L
D
A
-
L
G
------
V
N
I
-----
L
E
L
S
Q
L
I
Y
S
A
R
A
A
G
A
F
G
A
K
I
T
G
A
G
G
G
G
C
M
V
A
L
---
T
A
P
E
-
K
C
---
N
Q
V
A
E
A
V
A
G
A
G
G
K
V
T
I
-------------------------
38
HHSearch
50.65
19%
-28
- C2 -
-
4USK
1
?
A:
[5-331]
----
I
I
R
A
R
A
P
L
R
L
G
L
A
G
G
GTDV
A
P
Y
A
D
T
-
F
G
G
Y
V
L
N
A
T
I
D
R
Y
A
Y
A
V
I
K
T
L
T
I
P
A
V
R
F
V
S
T
D
----
Q
------
Q
------
V
------
E
K
H
Q
LISE--
P
------
L
E--
L
-------
N
G
-
T
-
L
N
-----------------------
L
H
-----------
K
A
V
Y
N
H
M
I
R
N
Y
N
H
----
G
K
P
I
A
L
E
L
S
T
F
C
D
A
----
P
---
A
G
S
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
N
L
P
------------
L
---------------
D
D
Y
A
I
A
Q
L
A
Y
R
I
E
R
V
D
C
G
L
A
G
G
R
Q
D
Q
Y
S
A
T
F
G
--
G
-
F
N
F
M
E
F
Y
A
A
A
R
T
----
I
V
N
P
L
---------------
R
I
K
N
W
V
L
C
E
L
E
A
S
L
V
L
F
Y
T
G
V
-
S
R
E
S
A
K
--
I
I
----------
Q
D
Q
---
S
D
------------
N
V
V
S
HK
T
A
A
I
E
---
A
M
H
G
I
---
K
R
E
A
L
V
M
K
E
A
L
L
-------
K
G
D
F
K
A
F
V
A
S
M
R
L
G
W
D
N
K
K
N
-
S
A
R
----
T
V
S
N
-----
A
H
I
D
E
I
Y
D
A
A
I
R
A
G
A
Q
A
G
K
V
S
G
A
G
G
G
G
F
M
L
F
F
---
V
P
T
E
K
R
----
M
D
L
I
R
T
L
G
E
Y
D
G
Q
V
S
N
-------------------------
39
HHSearch
50.54
19%
-27
- C2 -
-
4UTG
2
?
B:
[5-331]
----
I
I
R
A
R
A
P
L
R
L
G
L
A
G
G
GTDVAP
Y
A
D
T
-
F
G
G
Y
V
L
N
A
T
I
D
R
Y
A
Y
A
V
I
K
T
L
T
I
P
A
V
R
F
V
S
T
D
----
Q
------
Q
------
V
------
E
KHQLISE--
P
------
L
E--
L
-------
N
G
-
T
-
L
N
-----------------------
L
H
-----------
K
A
V
Y
N
H
M
I
R
N
Y
N
H
----
G
K
P
I
A
L
E
L
S
T
F
C
D
A
----
P
---
A
G
S
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
N
L
P
------------
L
---------------
D
D
Y
A
I
A
Q
L
A
Y
R
I
E
R
V
D
C
G
L
A
G
G
R
Q
D
Q
Y
S
A
T
F
G
--
G
-
F
N
F
M
E
F
Y
A
A
A
R
T
----
I
V
N
P
L
---------------
R
I
K
N
W
V
L
C
E
L
E
A
S
L
V
L
F
Y
T
G
V
-
S
R
E
S
A
K
--
I
I
----------
Q
D
Q
---
S
D
------------
N
V
V
SHKTAA
I
E
---
A
M
H
G
I
---
K
R
E
A
L
V
M
K
E
A
L
L
-------
K
G
D
F
K
A
F
V
A
S
M
R
L
G
W
D
N
K
K
N
-
S
A
R
----
T
V
S
N
-----
A
H
I
D
E
I
Y
D
A
A
I
R
A
G
A
Q
A
G
K
V
S
G
A
G
G
G
G
F
M
L
F
F
---
V
P
T
E
K
R
----
M
D
L
I
R
T
L
G
E
Y
D
G
Q
V
S
N
-------------------------
43
HHSearch
45.97
22%
5
- C2 -
-
1KKH
2
MVK_METJA
A:
[6-315]
-----
M
I
I
E
T
P
S
K
V
I
L
F
G
E
------
H
A
V
V
-
Y
G
Y
R
A
I
S
M
A
I
D
L
T
S
T
I
E
I
K
E
T
Q
E
D
E
I
I
L
N
L
N
D
----
L
N
K
S
L
G
L
N
------
L
------
N
---------
E
IKNINP
N
---
N
-------
F
G
-
D
-
F
K
-----------------------
Y
C
-----------
L
C
A
I
K
N
T
L
D
Y
L
N
I
----
E
P
K
T
G
F
K
I
N
I
S
S
K
I
----
P
---
I
S
C
G
L
G
S
S
A
S
I
T
I
G
T
I
K
A
V
S
G
F
Y
N
K
E
------------
L
---------------
K
D
D
E
I
A
K
L
G
Y
M
V
E
K
E
-
I
Q
G
K
A
S
I
T
D
T
S
T
I
T
Y
K
--
G
-
I
L
E
I
K
N
N
K
F
R
K
I
----
K
G
--------------------
E
F
E
-
E
F
L
K
N
C
K
F
L
I
V
Y
A
E
K
R
K
K
K
T
A
E
--
L
V
----------
N
E
V
---
A
K
------------
I
E
N
-----------
K
D
E
I
F
---
K
E
I
D
K
V
I
D
E
A
L
K
-------
I
K
N
K
E
D
F
G
K
L
M
T
K
N
H
E
L
L
K
K
-
L
N
------
I
S
T
-----
P
K
L
D
R
I
V
D
I
G
N
R
F
G
F
G
-
A
K
L
T
G
A
G
G
G
G
C
V
I
I
L
---
V
N
E
E
K
E
----
K
E
L
L
K
E
L
N
K
E
D
V
R
I
F
N
C
R
------------
M
----------
47
HHSearch
45.04
19%
-11
- C2 -
-
2R42
1
KIME_RAT
A:
[6-368]
-----
L
L
V
S
A
P
G
K
V
I
L
H
G
E
------
H
A
V
V
-
H
G
K
V
A
L
A
V
A
L
N
L
R
T
F
L
V
L
R
P
Q
S
N
G
K
V
S
L
N
L
P
N
----
V
------
G
I
K
Q
V
W
D
V
------
A
T
L
Q
L
LDTGF------------QLEK
L
--
K
K
-
V
-
A
G
-----------------------
L
P
R
D
C
V
G
NE
G
L
S
L
L
A
F
L
Y
L
Y
L
A
I
C
R
K
---
Q
R
T
L
P
S
L
D
I
M
V
W
S
E
L
----
P
---
P
G
A
G
L
G
S
S
A
A
Y
S
V
C
V
A
A
A
L
L
T
A
C
E
E
V
------------
T
NPLKDRGS
I
G
S
W
P
E
E
D
L
K
S
I
N
K
W
A
Y
E
G
E
R
V
-
I
H
G
N
P
S
G
V
D
N
S
V
S
T
W
G
--
G
-
A
L
R
Y
Q
Q
G
K
M
S
S
--------------------------
L
K
----
R
L
P
A
L
Q
I
L
L
T
N
T
K
V
-
P
R
S
T
K
A
--
L
V
----------
A
G
V
---
R
S
------------
R
L
I
K
F
P
E
I
M
A
P
---
L
L
T
S
I
---
D
A
I
S
L
E
C
E
R
V
L
G
E
M
A
A
APV
P
E
Q
Y
L
V
L
E
E
L
M
D
M
N
Q
H
H
L
N
A
-
L
G
------
V
G
H
-----
A
S
L
D
Q
L
C
Q
V
T
A
A
H
G
L
H
-
S
K
L
T
G
A
G
G
G
G
C
G
I
T
L
---
L
K
P
G
L
E
R
A
K
V
E
A
A
K
Q
A
L
T
G
C
G
F
D
C
W
--------------------------
22
PsiBlast_CBE
42.89
40%
-263
- C1 -
-
4UTG
2
?
B:
[115-159]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
N
L
P
------------
L
---------------
D
D
Y
A
I
A
Q
L
--
A
Y
R
I
E
-
R
V
D
C
G
L
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
42.30
40%
-258
- C1 -
-
4UTG
2
?
A:
[115-159]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
N
L
P
------------
L
---------------
D
D
Y
A
I
A
Q
L
--
A
Y
R
I
E
-
R
V
D
C
G
L
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
41.65
40%
-252
- C1 -
-
4UT4
1
?
A:
[115-159]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
N
L
P
------------
L
---------------
D
D
Y
A
I
A
Q
L
--
A
Y
R
I
E
-
R
V
D
C
G
L
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
41.48
21%
-50
- C2 -
-
2R3V
-
KIME_HUMAN
C:
[6-370]
-----
L
L
V
S
A
P
G
K
V
I
L
H
G
E
------
H
A
V
V
-
H
G
K
V
A
L
A
V
S
L
N
L
R
T
F
L
R
L
Q
P
H
S
N
G
K
V
D
L
S
L
P
N
----
I
------
G
IKRAWD
V
ARLQSL
D
---------
T
SFL----VTT
P
TSEQVEK
L
K
E
V
-
A
G
-----------------------
L
P
DDCAVTER---
L
A
V
L
A
F
L
Y
L
Y
L
S
I
CR
K
Q
R
A
L
P
S
L
D
I
V
V
W
S
E
L
----
P
---
P
G
A
G
L
G
S
S
A
A
Y
S
V
C
L
A
A
A
L
L
T
V
C
E
E
I
PNPLKDGDCVNR
W
TKE------------
D
L
E
L
I
N
K
W
A
F
Q
G
E
R
M
-
I
H
G
N
P
S
G
V
D
N
A
V
S
T
W
G
--
G
-
A
L
R
Y
H
Q
G
K
---
I
--------------------------
S
S
L
-
K
R
S
P
A
L
Q
I
L
L
T
N
T
K
V
-
P
R
N
T
R
A
--
L
V
----------
A
G
V
---
R
N
------------
R
L
L
KFPEIV
A
P
---
L
L
T
S
I
---
D
A
I
S
L
E
C
E
R
V
L
G
EMGEAPA
P
E
Q
Y
L
V
L
E
E
L
I
D
M
N
Q
H
H
L
N
A
-
L
G
------
V
G
H
-----
A
S
L
D
Q
L
C
Q
V
T
R
A
R
G
L
H
-
S
K
L
T
G
A
G
G
G
G
C
G
I
T
L
---
L
K
P
G
L
E
Q
PEV
E
A
T
K
Q
A
L
T
S
C
G
F
D
C
L
E
T
------------------------
56
HHSearch
40.96
19%
-22
- C2 -
-
2DEI
2
GAL1_PYRHO
A:
[1-325]
----
M
I
K
V
K
S
P
G
R
V
N
L
I
G
E
------
H
T
D
Y
-
T
Y
G
Y
V
M
P
M
A
I
N
L
Y
T
K
I
E
A
E
K
H
G
E
--
V
I
L
Y
S
E
H
----
F
G
E
E
R
K
F
S
------
L
------
N
---------
D
L-----
R
K--
E
-------
N
S
-
W
-
I
D
-----------------------
Y
V
-----------
K
G
I
F
W
V
L
K
E
S
-
D
-----
Y
E
V
G
G
I
K
G
R
V
S
G
N
L
----
P
---
L
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
T
L
D
K
L
Y
N
L
K
------------
L
---------------
D
S
L
S
K
V
L
L
A
K
K
A
E
N
E
F
V
G
V
P
C
G
I
L
D
Q
F
A
V
V
F
G
RE
G
N
V
I
F
L
D
T
H
T
L
-
D
Y
--------------------------
E
Y
I
-
P
F
P
K
D
V
S
I
L
V
F
Y
T
G
V
-
R
R
E
L
A
S
S
E
Y
A
E
R
K
H
I
A
E
E
S
L
K
I
L
---
G
K
GSSKEVREGELS
K
L
P
------
P
L
H
R
K
F
F
G
Y
I
V
R
E
N
A
R
V
L
E
V
R
D
A
L
K
-------
E
G
N
V
E
E
V
G
K
I
L
T
T
A
H
W
D
L
A
K
N
Y
E
------
V
S
C
-----
K
E
L
D
F
F
V
E
R
A
L
K
L
G
A
Y
G
A
R
L
T
G
A
G
F
G
G
S
A
I
A
L
---
V
D
K
E
D
A
----
E
T
I
G
E
E
I
----------------------------------
8
PsiBlast_PDB
40.57
40%
-235
- C1 -
-
4USK
-
?
A:
[115-159]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
N
L
P
------------
L
---------------
D
D
Y
A
I
A
Q
L
--
A
Y
R
I
E
-
R
V
D
C
G
L
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
40.56
40%
-251
* C1 *
-
4UT4
1
?
B:
[115-159]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
N
L
P
------------
L
---------------
D
D
Y
A
I
A
Q
L
--
A
Y
R
I
E
-
R
V
D
C
G
L
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
40.52
19%
2
- C2 -
-
1KVK
1
KIME_RAT
A:
[1-394]
MLS
E
V
L
L
V
S
A
P
G
K
V
I
L
H
G
E
------
H
A
V
V
H
-
G
K
V
A
L
A
V
A
L
N
L
R
T
F
L
V
L
R
P
Q
S
N
G
K
V
S
L
N
L
P
N
----
V
------
G
------
I
------
K
---------
Q
------
V
---
W
-------
D
V
-
A
-
T
L
Q
L
LDTE
K
L
K
K
V
A
G
L
P
R
D
C
V
G
NE
G
L
S
-----------
L
L
A
F
L
Y
L
Y
L
A
I
C
R
--
K
Q
R
T
L
P
S
L
D
I
M
V
W
S
E
L
----
P
P
G
A
---
G
L
G
S
S
A
A
Y
S
V
C
V
A
A
A
L
L
T
A
C
E
E
V
-----------------------------
T
N
P
L
K
D
R
G
S
I
G
S
W
P
-
E
E
D
L
K
S
I
N
K
W
A
Y
E
G
E
R
--
V
-
I
H
G
N
P
S
G
V
D
N
S
V
S
T
W
------
G
G
-
A
L
R
Y
Q
Q
G
-----
K
M
S
S
L
-
K
R
L
P
A
L
Q
I
L
L
T
N
T
K
V
-
P
R
S
T
K
A
--
L
V
----------
A
G
V
---
R
S
------------
R
L
I
K
F
P
E
I
M
A
P
---
L
L
T
S
I
---
D
A
I
S
L
E
C
E
R
V
L
G
-------
E
M
A
A
A
P
V
P
E
Q
Y
L
V
L
E
E
L
M
D
M
-
N
Q
H
----
H
L
N
A
L
GVGH
A
S
L
D
Q
L
C
Q
V
T
A
A
H
G
L
H
-
S
K
L
T
G
A
G
G
G
G
C
G
I
T
L
L
K
P
G
L
E
R
A
K
V
---
E
A
A
K
Q
A
L
T
G
C
G
F
D
C
W
E
T
S
IGAP
G
V
S
M
H
S
AT
S
I
E
D
P
V
R
Q
A
L
G
57
HHSearch
40.24
19%
-23
- C2 -
-
2CZ9
2
GAL1_PYRHO
A:
[1-325]
----
M
I
K
V
K
S
P
G
R
V
N
L
I
G
E
------
H
T
D
Y
-
T
Y
G
Y
V
M
P
M
A
I
N
L
Y
T
K
I
E
A
E
K
H
G
E
--
V
I
L
Y
S
E
H
----
F
G
E
E
R
K
F
S
------
L
------
N
---------
D
L-----
R
K--
E
-------
N
S
-
W
-
I
D
-----------------------
Y
V
-----------
K
G
I
F
W
V
L
K
E
S
-
D
-----
Y
E
V
G
G
I
K
G
R
V
S
G
N
L
----
P
---
L
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
T
L
D
K
L
Y
N
L
K
------------
L
---------------
D
S
L
S
K
V
L
L
A
K
K
A
E
N
E
F
V
G
V
P
C
G
I
L
D
Q
F
A
V
V
F
G
RE
G
N
V
I
F
L
D
T
H
T
L
-
D
Y
--------------------------
E
Y
I
-
P
F
P
K
D
V
S
I
L
V
F
Y
T
G
V
-
R
----
S
S
E
Y
A
E
R
K
H
I
A
E
E
S
L
K
I
L
---
G
K
GSSKEVREGELS
K
L
P
------
P
L
H
R
K
F
F
G
Y
I
V
R
E
N
A
R
V
L
E
V
R
D
A
L
K
-------
E
G
N
V
E
E
V
G
K
I
L
T
T
A
H
W
D
L
A
K
N
Y
E
------
V
S
C
-----
K
E
L
D
F
F
V
E
R
A
L
K
L
G
A
Y
G
A
R
L
T
G
A
G
F
G
G
S
A
I
A
L
---
V
D
K
E
D
A
----
E
T
I
G
E
E
I
----------------------------------
7
PsiBlast_PDB
40.09
40%
-238
- C1 -
-
4USM
-
?
A:
[115-159]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
N
L
P
------------
L
---------------
D
D
Y
A
I
A
Q
L
--
A
Y
R
I
E
-
R
V
D
C
G
L
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------