@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1958: (2018-01-23 )
MANRKIVVALGGNAILSSDPSAKAQQEALVETAKHLVKLIKNGDDLIITHGNGPQVGNLLLQHLASDSEKNPAFPLDSLVAMTEGSIGFWLKNALQNALLDEGIEKNVASVVTQVVVDKNDPAFVNLSKPIGPFYSEEEAKAEAEKSGATFKEDAGRGWRKVVASPKPVDIKEIETIRTLLNNGQVVVAAGGGGIPVVKENNGHLTGVEAVIDKDFASQRLAELVDADLFIVLTGVDYVFVNYNKPNQEKLEHVNVAQLEEYIKQDQFAPGSMLPKVEAAIAFVNGRPEGKAVITSLENLGALIESESGTIIEKG
Atome Classification :
(35 SA)
.........10....--...--.20--.--.--...--...30........40........50........60..-....--..70-........80........90........100.......110.......120.......130.......140-.-.......150.......160......-------.170.......180.......190.-....-..200.......210.......220.......230.......--240...-....250.......260.......270.......280..--...-..290........300....-.-..310...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAN
R
K
I
V
V
A
LGG
N
A
I--LSS--DPS--
A
--
K
--
A
Q
Q
--
E
A
L
V
E
T
A
K
H
L
V
K
L
IKNG
D
D
L
I
I
THGNGP
Q
V
G
N
L
L
L
Q
H
-
L
ASD--SEKN-PAFP
L
D
S
L
V
A
MTEG
S
I
G
F
W
L
K
N
A
L
Q
N
A
L
L
D
E
G
I
E
K
N
V
A
S
V
V
T
Q
V
VVDKND
P
A
F
V
NLSKPIGPFY
S
E
E
E
A
K
--
A
-
E
A
E
KSGAT
F
K
E
D
AGR
G
W
R
K
VVASPKP-------V
D
I
K
E
I
E
T
I
R
T
L
LNNG
Q
V
V
V
A
AGGG-G
I
P
V
-
V
KENNG
H
L
T
G
V
E
A
V
I
D
K
D
F
A
S
Q
R
L
A
E
L
VDA
D
L
F
I
V
L
TGV
D
Y
V
--
F
V
NYNK-P
N
Q
E
K
L
EHV
N
V
A
Q
L
E
E
Y
I
K
QDQFAPGSMLP
K
V
E
A
A
I
A
F
V--NGR-PE
G
K
-
A
V
I
T
S
L
E
N
L
G
A
L
I
ES-E-SG
T
I
IEKG
21
PsiBlast_CBE
93.82
64%
-92
- C4 -
-
2WE5
1
ARCC1_ENTFA
C:
[3-310]
---
K
K
M
V
V
A
L
G
G
N
A
I
--
L
S
N
--
D
A
S
--
A
--
H
--
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
A
A
D
--
S
E
K
N
-
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
----
E
A
M
Q
A
G
A
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
-------
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
G
Q
---
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
--
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
--
E
S
Q
-
P
N
K
Q
-
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
-
E
I
V
G
T
V
V
T
K
-
2
PsiBlast_PDB
92.72
64%
-93
- C4 -
-
2WE4
-
ARCC1_ENTFA
A:
[3-310]
---
K
K
M
V
V
A
L
G
G
N
A
I
--
L
S
N
--
D
A
S
--
A
--
H
--
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
A
A
D
--
S
E
K
N
-
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
----
E
A
M
Q
A
G
A
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
-------
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
G
Q
---
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
--
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
--
E
S
Q
-
P
N
K
Q
-
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
-
E
I
V
G
T
V
V
T
K
-
67
Fugue
92.65
64%
-89
- C4 -
-
1B7B
-
ARCC1_ENTFC
A:
[2-308]
--
G
K
K
M
V
V
A
L
G
G
N
A
I
--
L
S
N
--
D
A
S
--
A
--
H
--
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
A
A
D
--
S
E
K
N
-
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
--
E
-
A
M
Q
A
-
G
A
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
-------
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
G
Q
E
L
---
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
--
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
--
E
S
Q
-
P
N
K
Q
-
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
-
E
I
V
G
T
V
V
---
1
PsiBlast_PDB
92.64
64%
-91
- C4 -
-
1B7B
-
ARCC1_ENTFC
A:
[3-308]
---
K
K
M
V
V
A
L
G
G
N
A
I
--
L
S
N
--
D
A
S
--
A
--
H
--
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
A
A
D
--
S
E
K
N
-
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
----
E
A
M
Q
A
G
A
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
-------
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
G
Q
---
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
--
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
--
E
S
Q
-
P
N
K
Q
-
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
-
E
I
V
G
T
V
V
---
22
PsiBlast_CBE
92.37
64%
-94
- C4 -
-
2WE5
1
ARCC1_ENTFA
B:
[3-310]
---
K
K
M
V
V
A
L
G
G
N
A
I
--
L
S
N
--
D
A
S
--
A
--
H
--
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
A
A
D
--
S
E
K
N
-
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
----
E
A
M
Q
A
G
A
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
-------
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
G
Q
---
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
--
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
--
E
S
Q
-
P
N
K
Q
-
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
-
E
I
V
G
T
V
V
T
K
-
3
PsiBlast_PDB
92.28
64%
-90
- C4 -
-
2WE5
1
ARCC1_ENTFA
A:
[3-310]
---
K
K
M
V
V
A
L
G
G
N
A
I
--
L
S
N
--
D
A
S
--
A
--
H
--
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
A
A
D
--
S
E
K
N
-
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
----
E
A
M
Q
A
G
A
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
-------
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
G
Q
---
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
--
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
--
E
S
Q
-
P
N
K
Q
-
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
-
E
I
V
G
T
V
V
T
K
-
68
Fugue
86.59
63%
-17
- C4 -
-
1B7B
-
ARCC1_ENTFC
A:
[2-308]
--
G
K
K
M
V
V
A
L
G
G
N
A
I
--
L
S
N
--
D
A
S
--
A
--
H
--
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
A
A
D
--
S
E
K
-
N
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
--
E
-
A
M
Q
A
-
G
A
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
-------
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
-
V
G
---
Q
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
--
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
--
E
S
Q
-
P
N
K
Q
-
A
I
I
T
S
L
E
N
L
G
S
--
M
S
-
G
-
D
E
I
V
G
T
V
V
48
HHSearch
84.06
63%
-13
- C4 -
-
2WE4
-
ARCC1_ENTFA
D:
[2-310]
--
G
K
K
M
V
V
A
L
G
G
N
A
I
--
L
S
N
--
D
A
S
--
A
--
H
--
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
A
A
D
S
---
E
K
N
-
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
-
E
A
E
A
--
K
-
E
A
M
Q
A
G
A
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
-------
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
V
G
Q
E
L
K
----
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
--
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
--
E
-
S
Q
P
N
K
Q
-
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
T
K
-
47
HHSearch
83.88
63%
-17
- C4 -
-
2WE5
1
ARCC1_ENTFA
A:
[2-310]
--
G
K
K
M
V
V
A
L
G
G
N
A
I
--
L
S
N
--
D
A
S
--
A
--
H
--
A
Q
Q
--
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
A
A
D
S
---
E
K
N
-
P
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
-
E
A
E
A
--
K
-
E
A
M
Q
A
G
A
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
-------
I
D
I
H
E
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
-
G
I
P
V
V
G
Q
E
L
K
----
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
V
--
C
I
N
Y
G
K
-
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
--
E
-
S
Q
P
N
K
Q
-
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
T
K
-
29
PsiBlast_CBE
80.35
45%
8
- C4 -
-
1E19
1
CPKA_PYRFU
B:
[2-310]
--
G
K
R
V
V
I
A
L
G
G
N
A
L
QQ
R
G
Q
--
K
G
S
--
Y
--
E
--
E
M
M
--
D
N
V
R
K
T
A
R
Q
I
A
E
I
I
A
R
G
Y
E
V
V
I
T
H
G
N
G
P
Q
V
G
S
L
L
L
H
M
-
D
A
G
Q
--
A
T
Y
G
I
P
A
Q
P
M
D
V
A
G
A
M
S
Q
G
W
I
G
Y
M
I
Q
Q
A
L
K
N
E
L
R
K
R
G
M
E
K
K
V
V
T
I
I
T
Q
T
I
V
D
K
N
D
P
A
F
Q
N
P
T
K
P
V
G
P
F
Y
D
E
E
T
A
K
--
R
-
L
A
R
E
K
G
W
I
V
K
E
D
S
G
R
G
W
R
R
V
V
P
S
P
D
P
-------
K
G
H
V
E
A
E
T
I
K
K
L
V
E
R
G
V
I
V
I
A
S
G
G
G
-
G
V
P
V
-
I
L
E
-
D
G
E
I
K
G
V
E
A
V
I
D
K
D
L
A
G
E
K
L
A
E
E
V
N
A
D
I
F
M
I
L
T
D
V
N
G
A
--
A
L
Y
Y
G
T
-
E
K
E
Q
W
L
R
E
V
K
V
E
E
L
R
K
Y
Y
E
E
G
H
F
K
A
G
S
M
G
P
K
V
L
A
A
I
R
F
I
--
E
W
G
-
G
E
-
R
-
A
I
I
A
H
L
E
K
A
V
E
A
L
E
G
-
K
-
T
G
T
-----
4
PsiBlast_PDB
80.02
45%
9
- C4 -
-
1E19
1
CPKA_PYRFU
A:
[2-310]
--
G
K
R
V
V
I
A
L
G
G
N
A
L
QQ
R
G
Q
--
K
G
S
--
Y
--
E
--
E
M
M
--
D
N
V
R
K
T
A
R
Q
I
A
E
I
I
A
R
G
Y
E
V
V
I
T
H
G
N
G
P
Q
V
G
S
L
L
L
H
M
-
D
A
G
Q
--
A
T
Y
G
I
P
A
Q
P
M
D
V
A
G
A
M
S
Q
G
W
I
G
Y
M
I
Q
Q
A
L
K
N
E
L
R
K
R
G
M
E
K
K
V
V
T
I
I
T
Q
T
I
V
D
K
N
D
P
A
F
Q
N
P
T
K
P
V
G
P
F
Y
D
E
E
T
A
K
--
R
-
L
A
R
E
K
G
W
I
V
K
E
D
S
G
R
G
W
R
R
V
V
P
S
P
D
P
-------
K
G
H
V
E
A
E
T
I
K
K
L
V
E
R
G
V
I
V
I
A
S
G
G
G
-
G
V
P
V
-
I
L
E
-
D
G
E
I
K
G
V
E
A
V
I
D
K
D
L
A
G
E
K
L
A
E
E
V
N
A
D
I
F
M
I
L
T
D
V
N
G
A
--
A
L
Y
Y
G
T
-
E
K
E
Q
W
L
R
E
V
K
V
E
E
L
R
K
Y
Y
E
E
G
H
F
K
A
G
S
M
G
P
K
V
L
A
A
I
R
F
I
--
E
W
G
-
G
E
-
R
-
A
I
I
A
H
L
E
K
A
V
E
A
L
E
G
-
K
-
T
G
T
-----
9
PsiBlast_PDB
75.75
41%
9
- C4 -
-
2E9Y
-
?
A:
[4-316]
--
G
R
L
A
V
I
A
L
G
G
N
A
I
--
A
G
P
GM
D
V
S
--
V
--
E
--
S
Q
T
--
A
A
V
K
R
A
S
S
I
I
A
D
V
L
A
D
G
W
R
S
V
I
T
H
G
N
G
P
Q
V
G
Y
L
S
E
A
F
-
E
A
L
P
--
P
E
R
--
P
R
Q
P
L
Y
I
A
T
A
M
T
Q
A
W
I
G
L
L
L
K
H
S
L
E
E
E
L
R
R
R
G
L
N
V
L
V
P
V
V
I
S
R
V
L
V
D
V
S
D
P
S
F
N
N
P
S
K
P
V
G
P
I
Y
G
R
E
E
A
E
--
E
-
L
S
R
R
Y
G
W
V
F
K
R
D
P
R
G
G
F
R
R
V
V
P
S
P
R
P
-------
V
S
I
V
D
R
D
L
I
A
E
A
S
A
E
S
P
A
V
V
A
L
G
G
G
-
G
V
P
V
-
V
E
R
P
G
G
V
L
E
P
V
E
A
V
V
D
K
D
L
A
S
S
L
L
A
T
Q
L
N
A
D
L
L
V
I
L
T
D
V
P
G
V
--
A
V
N
Y
G
R
-
E
G
E
R
W
L
R
R
A
A
A
S
E
L
K
K
Y
L
R
E
G
H
F
P
P
G
S
M
G
P
K
V
E
A
A
I
S
F
V
E
R
T
G
K
-
P
----
A
V
I
G
S
L
E
E
A
R
Q
V
L
S
L
-
Q
-
A
G
T
V
V
M
L
G
45
HHSearch
75.59
41%
4
- C4 -
-
2E9Y
-
?
A:
[4-316]
--
G
R
L
A
V
I
A
L
G
G
N
A
I
--
A
G
P
--
G
M
D
VS
V
--
E
--
S
Q
T
--
A
A
V
K
R
A
S
S
I
I
A
D
V
L
A
D
G
W
R
S
V
I
T
H
G
N
G
P
Q
V
G
Y
L
S
E
A
F
-
E
A
L
P
--
P
E
R
--
P
R
Q
P
L
Y
I
A
T
A
M
T
Q
A
W
I
G
L
L
L
K
H
S
L
E
E
E
L
R
R
R
G
L
N
V
L
V
P
V
V
I
S
R
V
L
V
D
V
S
D
P
S
F
N
N
P
S
K
P
V
G
P
I
Y
G
-
R
E
E
A
--
E
E
L
S
R
R
Y
G
W
V
F
K
R
D
P
R
G
G
F
R
R
V
V
P
S
P
R
P
-------
V
S
I
V
D
R
D
L
I
A
E
A
S
A
E
S
P
A
V
V
A
L
G
G
G
-
G
V
P
V
-
V
E
R
P
G
G
V
L
E
P
V
E
A
V
V
D
K
D
L
A
S
S
L
L
A
T
Q
L
N
A
D
L
L
V
I
L
T
D
V
P
G
V
--
A
V
N
Y
G
R
-
E
G
E
R
W
L
R
R
A
A
A
S
E
L
K
K
Y
L
R
E
G
H
F
P
P
G
S
M
G
P
K
V
E
A
A
I
S
F
V
--
E
-
R
-
T
G
K
P
-
A
V
I
G
S
L
E
E
A
R
Q
V
L
S
L
-
Q
-
A
G
T
V
V
M
L
G
35
PsiBlast_CBE
75.25
40%
10
- C4 -
-
4JZ9
1
?
B:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
YD
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
34
PsiBlast_CBE
75.01
40%
10
- C4 -
-
4JZ9
1
?
C:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
YD
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
40
PsiBlast_CBE
74.81
40%
14
- C4 -
-
4JZ7
1
?
C:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
YD
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
39
PsiBlast_CBE
74.77
40%
8
- C4 -
-
4JZ7
1
?
D:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
YD
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
6
PsiBlast_PDB
74.60
40%
10
- C4 -
-
4JZ8
1
?
A:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
46
HHSearch
74.23
44%
57
- C4 -
-
1E19
1
CPKA_PYRFU
A:
[2-314]
--
G
K
R
V
V
I
A
L
G
G
N
A
L
--
Q
Q
R
--
G
Q
K
--
G
S
Y
E
--
E
M
M
--
D
N
V
R
K
T
A
R
Q
I
A
E
I
I
A
R
G
Y
E
V
V
I
T
H
G
N
G
P
Q
V
G
S
L
L
L
H
M
-
D
A
G
Q
A
T
Y
G
-
I
-
P
A
Q
P
M
D
V
A
G
A
M
S
Q
G
W
I
G
Y
M
I
Q
Q
A
L
K
N
E
L
R
K
R
G
M
E
K
K
V
V
T
I
I
T
Q
T
I
V
D
K
N
D
P
A
F
Q
N
P
T
K
P
V
G
P
F
Y
D
-
E
E
T
A
--
K
R
L
A
R
E
K
G
W
I
V
K
E
D
S
G
R
G
W
R
R
V
V
P
S
P
D
P
-------
K
G
H
V
E
A
E
T
I
K
K
L
V
E
R
G
V
I
V
I
A
S
G
G
G
-
G
V
P
V
-
I
L
E
-
D
G
E
I
K
G
V
E
A
V
I
D
K
D
L
A
G
E
K
L
A
E
E
V
N
A
D
I
F
M
I
L
T
D
V
N
G
A
A
L
Y
Y
G
T
E
K
---
E
Q
W
L
R
E
V
K
V
E
E
L
R
K
Y
Y
E
E
G
H
F
K
A
G
S
M
G
P
K
V
L
A
A
I
R
F
I
--
E
-
W
-
G
G
E
R
-
A
I
I
A
H
L
E
K
A
V
E
A
L
E
G
-
K
-
T
G
T
Q
V
L
P
-
7
PsiBlast_PDB
74.03
40%
11
- C4 -
-
4JZ9
1
?
A:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
33
PsiBlast_CBE
73.93
40%
12
- C4 -
-
4JZ9
1
?
D:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
YD
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
38
PsiBlast_CBE
73.90
40%
14
- C4 -
-
4JZ8
1
?
B:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
------
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
8
PsiBlast_PDB
73.77
40%
9
- C4 -
-
4OLC
2
?
A:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D
-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
--------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
32
PsiBlast_CBE
73.50
40%
14
- C4 -
-
4OLC
2
?
B:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
YD
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
--------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
37
PsiBlast_CBE
73.49
40%
13
- C4 -
-
4JZ8
1
?
C:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
YD
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
------
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
31
PsiBlast_CBE
73.39
40%
11
- C4 -
-
4OLC
2
?
C:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
YD
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
--------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
36
PsiBlast_CBE
73.36
40%
15
- C4 -
-
4JZ8
1
?
D:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
YD
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
------
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
30
PsiBlast_CBE
73.31
40%
8
- C4 -
-
4OLC
1
?
D:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
YD
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
A
K
D-
L
-
M
A
A
N
P
G
K
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
--------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
44
PsiBlast_CBE
70.32
40%
10
- C4 -
-
3KZF
1
?
B:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
---------------
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
--
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
--
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
5
PsiBlast_PDB
69.58
40%
5
- C4 -
-
4JZ7
1
?
A:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
---------------------------------
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
59
HHSearch
69.49
36%
18
* C4 *
-
4JZ9
1
?
A:
[3-316]
S
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
--
Y
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
A
---
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
-
E
Q
E
A
K
D
L
-
M
A
A
N
P
G
K
I
L
R
E
D
--
A
G
R
-----
G
W
R
V
V
V
PSPRP
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
-
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
-
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
-
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
--
Q
-
A
-
T
G
K
M
-
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
58
HHSearch
68.88
36%
17
- C4 -
-
4JZ8
1
?
D:
[3-316]
S
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
--
Y
D
T
QR
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
A
---
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
-
E
Q
E
A
KD
L
-
M
A
A
N
P
G
K
I
L
R
E
D
--
A
G
R
-----
G
W
R
V
VVPSPRP
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
-
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
-
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
-
N
-----
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
--
Q
-
A
-
T
G
K
M
-
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
43
PsiBlast_CBE
68.82
40%
8
- C4 -
-
3KZF
1
?
C:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
--------------------------
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
Y
K
-----
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
41
PsiBlast_CBE
68.31
40%
11
- C4 -
-
4JZ7
1
?
B:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
---------------------------------
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
I
N
Y
K
K
-
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-
42
PsiBlast_CBE
67.46
40%
15
- C4 -
-
3KZF
1
?
D:
[4-316]
-
A
G
K
T
V
V
I
A
L
G
G
N
A
M
--
L
Q
A
--
K
E
K
--
G
--
D
Y
D
T
Q
R
--
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
-
Q
A
A
---
A
G
V
S
-
P
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
---------------
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
-------
L
E
I
V
E
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
-
G
I
P
C
-
K
R
E
N
K
-
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
A
--
C
--------
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
--
G
S
M
G
P
K
V
R
A
A
I
E
F
T
----
Q
-
A
T
G
K
M
S
I
I
T
S
L
S
T
A
V
D
A
L
N
G
-
K
-
C
G
T
R
I
I
K
-