@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKR5: (2017-10-28 )
MNQKFKLPLAIAIASAVLVGCSSNKVKEAKPNPLPKLTESNKSLVPVFSRSVSSTNKADPLRLQLDASEGVVFTLDPKGEVAAYRGKQRLWEKKVSKLGLSSGVEAAEGIVVVGNSKGQLFALDQATGEQKWTAQLSGALLSPSLVQSGRVITIANDGTVFAHDVSSGQQVWAYKLPNVQFSLRGQPSPVSLDPRTVLIASANAYVYAIDTISGIPHFQRRVAVSEGRSDIQRLIDIDGDPVVAGQLMVTTSFQGQVTVTDLASQRVVWSEDSSSTKRPEVYDNKVFVSSTDGKLTAYDLTTGEQLWQNDSLLNRHLSNPVVLGSDLIVGDLDGVLHLIDPTTGKLIGRSKTSGEVNTLRVIEKQLYVSTRKGDLSIWQNR
Atome Classification :
(20 SA)
.........10........20....--....30........40......-------..50........60........70.......-..80...--.--.-------.--..--90.......---------.----------100-----.-.--...--.----..110.......120.......130.....-----.-----.-----140........-----------150...------.------...160.......170..--.....180----.-..------------------------------.---------------------------------.....190........200-.-----------------.----------------.....210..---.....220.......230.------------------......240------...---....250-........260......---------.270-...---------------.-------------------------------.---------------------------------------..280--.......290-------------------------------.---------------------------------------........300.......310.......320-.......330.......340.......350--...-.--...360.--......--..370.......380-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNQKFKL
P
L
A
I
A
I
A
S
A
V
L
VGCSSNK--VKEAKPNPLPKLTESNK
S
L
V
P
V
-------
F
S
RSVSSTNKAD
P
L
R
L
Q
L
DASE
G
-
V
V
F
T
LDP-KG
E
V
A
A
Y
--
R
--
G
-------
K
--
Q
R
--
L
W
E
K
K
V
S
KL---------G----------LS------S-G--VEA--A----E
G
I
V
V
V
GNSK
G
Q
L
F
A
L
DQATGE
Q
K
W
T
A
Q
LS-----G-----A-----L-L
S
P
S
L
VQSG-----------
R
V
I
T
I
A------N------D
G
T
V
F
A
H
DVSSG
Q
Q
V
W
A
Y
--KLP
N
V
Q
------
F
-
S
L------------------------------R---------------------------------GQPSPVS-LDP
R
T
V
L
I
ASA-N-----------------
A
----------------
Y
V
Y
A
IDTISG---I
P
H
F
Q
R
R
V
A
VSE
G
R
S
D
I
Q
R
------------------
L
IDIDGDP
V
------
V
A
G
---
Q
L
M
V
T
T--SFQG
Q
V
T
V
TDLASQ
R
V
V
---------WSED-SSS---------------T-------------------------------K---------------------------------------RPEVY--D
N
K
V
F
V
SS---------------------------------T---------------------------------------DG
K
L
T
A
Y
DLT
T
G
E
Q
L
WQN
D
S
L
L
N
R
HLSN
P
V
V
-LGSD
L
I
V
GDL
D
G
V
L
H
LIDPTTG
K
L
I
GRSKT--SGE-
V
--
N
T
L
R
--
V
--
I
E
K
Q
L
Y
--
V
STRKGDLSIWQNR--
22
Fugue
85.11
30%
-
- C2 -
-
4HDJ
-
BAMB_PSEAE
A:
[28-382]
-------------------------------
P
P
A
E
L
T
D
-
F
K
E
E
V
V
L
S
K
Q
-------
W
S
R
S
V
G
D
G
Q
G
D
L
Y
N
L
L
E
P
A
V
D
G
S
-
T
I
Y
A
A
S
A
-
E
G
R
V
M
A
I
--
Q
--
R
-------
E
TG
D
V
--
L
W
K
K
D
L
E
R
----------
P
----------
V
S
------
G
-
G
--
V
G
V
--
G
----
Y
G
L
V
L
V
G
T
L
R
G
D
V
I
A
L
D
E
A
T
G
K
K
K
W
T
K
R
V
N
-----
S
-----
E
-----
V
-
L
S
A
P
A
T
N
G
D
-----------
V
V
V
V
Q
T
------
Q
------
D
D
K
L
I
G
L
D
A
A
S
G
D
Q
R
W
I
Y
--
E
S
T
V
P
V
------
L
-
T
L
------------------------------
R
---------------------------------
G
T
G
A
P
L
I
--
A
G
N
M
A
L
A
G
L
A
-
S
-----------------
G
----------------
K
V
V
A
V
D
V
Q
R
G
---
L
P
I
W
E
Q
R
V
A
I
P
Q
G
R
S
E
L
D
R
------------------
V
V
D
I
D
G
G
L
L
------
L
S
G
---
D
T
L
Y
V
V
--
S
Y
Q
G
R
A
A
A
L
D
V
N
S
G
R
L
L
---------
W
Q
R
E
-
A
S
S
---------------
Y
-------------------------------
V
---------------------------------------
G
V
A
E
G
--
F
G
N
I
Y
V
S
Q
---------------------------------
A
---------------------------------------
S
G
S
V
E
G
L
D
S
R
G
A
S
S
L
W
N
N
D
A
L
A
R
R
Q
L
S
A
P
A
V
-
F
S
S
N
V
V
V
G
D
L
E
G
Y
V
H
L
L
S
Q
V
D
G
R
F
V
G
R
E
R
V
D
S
D
G
V
-
R
--
V
R
P
L
--
V
--
V
G
S
W
M
Y
--
V
F
G
N
G
G
K
L
V
A
Y
T
I
R
PG
3
HHSearch
83.80
30%
-
- C2 -
-
4HDJ
-
BAMB_PSEAE
A:
[28-379]
-------------------------------
P
P
A
E
L
T
D
F
K
E
E
-
V
V
L
S
K
Q
-------
W
S
R
S
V
G
D
G
Q
G
D
L
Y
N
L
L
E
P
A
V
D
G
S
-
T
I
Y
A
A
S
A
-
E
G
R
V
M
A
I
QR
E
--
T
-------
G
--
D
V
--
L
W
K
K
D
L
E
-
R
---------
P
----------
V
S
------
G
-
G
--
V
G
V
--
G
----
Y
G
L
V
L
V
G
T
L
R
G
D
V
I
A
L
D
E
A
T
G
K
K
K
W
T
K
R
V
N
-----
S
-----
E
-----
V
-
L
S
A
P
A
T
N
G
D
-----------
V
V
V
V
Q
T
------
Q
------
D
D
K
L
I
G
L
D
A
A
S
G
D
Q
R
W
I
Y
--
E
S
T
V
P
V
------
L
-
T
L
------------------------------
R
---------------------------------
G
T
G
A
P
L
I
-
A
G
N
M
-
A
L
A
G
L
A
-
S
-----------------
G
----------------
K
V
V
A
V
D
V
Q
R
G
---
L
P
I
W
E
Q
R
V
A
I
P
Q
G
R
S
E
L
D
R
------------------
V
V
D
I
D
G
G
L
L
------
L
S
G
---
D
T
L
Y
V
V
--
S
Y
Q
G
R
A
A
A
L
D
V
N
S
G
R
L
L
---------
W
Q
R
E
-
A
S
S
---------------
Y
-------------------------------
V
---------------------------------------
G
V
A
E
G
--
F
G
N
I
Y
V
S
Q
---------------------------------
A
---------------------------------------
S
G
S
V
E
G
L
D
S
R
G
A
S
S
L
W
N
N
D
A
L
A
R
R
Q
L
S
A
P
A
V
-
F
S
S
N
V
V
V
G
D
L
E
G
Y
V
H
L
L
S
Q
V
D
G
R
F
V
G
R
E
R
V
--
D
S
D
-
G
VR
V
R
P
L
--
V
--
V
G
S
W
M
Y
--
V
F
G
N
G
G
K
L
V
A
Y
T
I
---
2
HHSearch
78.94
33%
-8
- C2 -
-
4IMM
-
?
A:
[45-391]
--------------------------------------------
V
L
T
Q
V
-------
S
S
I
R
L
D
Q
-------
D
L
Q
I
A
P
L
A
D
-
G
M
I
A
A
S
R
-
S
G
I
V
S
G
Y
--
M
--
G
-------
E
--
S
I
--
A
W
Q
Y
N
A
E
-
D
---------
V
----------
I
T
------
G
-
G
VG
I
D
D
--
Q
----
G
S
V
A
V
I
G
T
R
S
G
K
L
I
A
L
D
A
R
T
G
A
A
R
W
V
V
E
L
A
-----
S
-----
S
-----
S
-
L
A
P
A
L
I
S
G
D
-----------
K
V
I
V
I
T
------
N
------
S
G
T
I
F
G
L
D
I
N
S
G
A
T
V
W
Q
Y
--
A
T
Q
V
P
N
------
T
-
S
V
------------------------------
R
---------------------------------
G
M
A
K
P
L
A
-
L
D
A
R
T
V
L
I
G
G
A
-
D
-----------------
G
----------------
R
I
H
A
L
D
T
M
T
G
---
A
P
V
W
T
R
R
V
G
L
A
M
G
S
G
E
I
D
Q
------------------
L
R
D
I
D
G
T
P
T
------
V
V
D
---
H
Y
L
Y
A
A
--
S
Y
S
G
Q
L
A
G
F
D
M
T
T
G
R
T
M
---------
F
V
S
E
-
L
S
S
---------------
T
-------------------------------
K
---------------------------------------
K
L
T
T
L
--
A
D
A
V
I
G
S
S
---------------------------------
T
---------------------------------------
D
G
D
V
V
A
F
N
R
M
T
G
E
K
L
W
E
N
H
D
L
K
Y
R
G
L
T
N
P
V
T
-
I
G
T
Y
I
A
V
G
D
A
D
G
V
V
H
I
L
N
-
H
Q
G
Q
I
I
S
R
A
N
T
--
K
G
A
-
L
--
T
N
L
T
--
V
--
I
N
N
R
L
Y
--
A
Q
S
A
D
G
V
V
T
V
W
Q
----
32
PsiBlast_PDB
77.57
33%
-9
- C2 -
-
4IMM
-
?
A:
[45-391]
--------------------------------------------
V
L
T
Q
V
S
S
I
R
L
D
Q--------------
D
L
Q
I
A
P
L
A
D
-
G
M
I
A
A
S
R
-
S
G
I
V
S
G
Y
--
M
--
G
-------
E
--
S
I
--
A
W
Q
Y
N
A
E
D
V
---------
I
----------
T
G
------
G
V
G
--
I
D
D
--
Q
----
G
S
V
A
V
I
G
T
R
S
G
K
L
I
A
L
D
A
R
T
G
A
A
R
W
V
V
E
L
A
-----
S
-----
S
-----
S
-
L
A
P
A
L
I
S
G
D
-----------
K
V
I
V
I
T
------
N
------
S
G
T
I
F
G
L
D
I
N
S
G
A
T
V
W
Q
Y
A
T
Q
V
P
N
T
---------
S
V
------------------------------
R
---------------------------------
G
M
A
K
P
L
A
-
L
D
A
R
T
V
L
I
G
G
A
-
D
-----------------
G
----------------
R
I
H
A
L
D
T
M
T
G
---
A
P
V
W
T
R
R
V
G
L
A
M
G
S
G
E
I
D
Q
------------------
L
R
D
I
D
G
T
P
T
------
V
V
D
---
H
Y
L
Y
A
A
--
S
Y
S
G
Q
L
A
G
F
D
M
T
T
G
R
T
M
---------
F
V
S
E
-
L
S
S
---------------
T
-------------------------------
K
---------------------------------------
K
L
T
T
L
--
A
D
A
V
I
G
S
S
---------------------------------
T
---------------------------------------
D
G
D
V
V
A
F
N
R
M
T
G
E
K
L
W
E
N
H
D
L
K
Y
R
G
L
T
N
P
V
T
-
I
G
T
Y
I
A
V
G
D
A
D
G
V
V
H
I
L
N
H
-
Q
G
Q
I
I
S
R
A
N
T
--
K
G
A
-
L
--
T
N
L
T
--
V
--
I
N
N
R
L
Y
--
A
Q
S
A
D
G
V
V
T
V
W
Q
----
1
HHSearch
77.02
33%
-13
- C2 -
-
4IMM
-
?
B:
[44-391]
-------------------------------------------
A
V
L
T
Q
V
-------
S
S
I
R
L
D
Q
-------
D
L
Q
I
A
P
L
A
D
-
G
M
I
A
A
S
R
-
S
G
I
V
S
G
Y
--
M
--
G
----------
S
I
--
A
W
Q
Y
N
A
E
-
D
---------
V
----------
I
T
------
G
-
G
V
G
I
D
D
--
Q
----
G
S
V
A
V
I
G
T
R
S
G
K
L
I
A
L
D
A
R
T
G
A
A
R
W
V
V
E
L
A
-----
S
-----
S
-----
S
-
L
A
P
A
L
I
S
G
D
-----------
K
V
I
V
I
T
------
N
------
S
G
T
I
F
G
L
D
I
N
S
G
A
T
V
W
Q
Y
--
A
T
-------------
V
------------------------------
R
---------------------------------
G
M
A
K
P
L
A
-
L
D
A
R
T
V
L
I
G
G
A
-
D
-----------------
G
----------------
R
I
H
A
L
D
T
M
T
G
---
A
P
V
W
T
R
R
V
G
L
---------------------------
L
R
D
I
D
G
T
P
T
------
V
V
D
---
H
Y
L
Y
A
A
--
S
Y
S
G
Q
L
A
G
F
D
M
T
T
G
R
T
M
---------
F
V
S
E
-
L
S
S
---------------
T
-------------------------------
K
---------------------------------------
K
L
T
T
L
--
A
D
A
V
I
G
S
S
---------------------------------
T
---------------------------------------
D
G
D
V
V
A
F
N
R
M
T
G
E
K
L
W
E
N
H
D
L
K
Y
R
G
L
T
N
P
V
T
-
I
G
T
Y
I
A
V
G
D
A
D
G
V
V
H
I
L
N
-
H
Q
G
Q
I
I
S
R
A
N
T
--
K
G
A
-
L
--
T
N
L
T
--
V
--
I
N
N
R
L
Y
--
A
Q
S
A
D
G
V
V
T
V
W
Q
----
33
PsiBlast_PDB
68.52
30%
-
- C2 -
-
4HDJ
-
BAMB_PSEAE
A:
[28-374]
-------------------------------
P
P
A
E
L
T
D
F
K
E
-
E
V
V
L
S
K
Q
-------
W
S
R
S
V
G
D
-
G
Q
G
D
L
Y
N
L
L
E
P
A
V
D
G
S
T
I
Y
A
A
S
A
-
E
G
R
V
M
A
I
--
Q
--
R
-------
E
--
T
G
DV
L
W
K
K
D
L
E
R
P
---------
V
----------
S
G
------
G
-
V
--
G
V
G
--
Y
----
G
L
V
L
V
G
-
T
L
R
G
D
V
I
A
L
D
E
A
T
G
K
K
K
W
T
K
R
V
N
-----
S
-----
E
-----
V
-
L
S
A
P
A
T
N
G
D
-----------
V
V
V
V
Q
T
------
Q
------
D
D
K
L
I
G
L
D
A
A
S
G
D
Q
R
W
I
Y
--
E
S
T
V
P
V
------
L
-
T
L
------------------------------
R
---------------------------------
G
T
G
A
P
L
--
I
A
G
N
M
A
L
A
G
L
A
-
S
-----------------
G
----------------
K
V
V
A
V
D
V
Q
R
G
---
L
P
I
W
E
Q
R
V
A
I
P
Q
G
R
S
E
L
D
R
------------------
V
V
D
I
D
G
G
L
L
------
L
S
G
---
D
T
L
Y
V
V
--
S
Y
Q
G
R
A
A
A
L
D
V
N
S
G
R
L
L
---------
W
Q
R
E
-
A
S
S
Y--------------
V
-------------------------------
G
---------------------------------------
V
A
E
G
F
--
G
N
-
I
Y
V
S
Q
---------------------------------
A
---------------------------------------
S
G
S
V
E
G
L
D
S
R
G
A
S
S
L
W
N
N
D
A
L
A
R
R
Q
L
S
A
P
A
V
-
F
S
S
N
V
V
V
G
D
L
E
G
Y
V
H
L
L
S
Q
V
D
G
R
F
V
G
R
E
R
V
--
D
S
D
-
G
--
V
R
V
R
P
L
V
--
V
G
S
W
M
Y
--
V
F
G
N
G
G
K
L
--------
38
PsiBlast_PDB
68.27
27%
0
- C2 -
-
3P1L
-
?
A:
[32-362]
-------------------------------
K
M
S
P
L
P
T
V
-
E
N
Q
F
T
P
T
T
A
-------
W
S
T
S
V
G
S
G
I
G
N
F
Y
S
N
L
H
P
A
L
A
D
N
-
V
V
Y
A
A
D
R
-
A
G
L
V
K
A
L
--
N
--
A
-------
D
DG
K
E
--
I
W
S
V
S
L
A
E
K
---------
D
G
WFSKEPAL-
L
S
------
G
-
G
--
V
T
V
--
S
----
G
G
H
V
Y
I
G
S
E
K
A
Q
V
Y
A
L
N
T
S
D
G
T
V
A
W
Q
T
K
V
A
-----
G
-----
E
-----
A
-
L
S
R
P
V
V
S
D
G
-----------
L
V
L
I
H
T
------
S
------
N
G
Q
L
Q
A
L
N
E
A
D
G
A
V
K
W
T
V
--
N
L
D
M
P
S
------
L
-
S
L
------------------------------
R
---------------------------------
G
E
S
A
P
T
T
-
A
F
G
A
A
V
-
V
G
G
D
-
N
-----------------
G
----------------
R
V
S
A
V
L
M
E
Q
G
---
Q
M
I
W
Q
Q
R
I
S
Q
A
T
G
S
T
E
I
D
R
------------------
L
S
D
V
D
T
T
P
V
------
V
V
N
---
G
V
V
F
A
L
--
A
Y
N
G
N
L
T
A
L
D
L
R
S
G
Q
I
M
---------
W
K
R
E
-
L
G
S
---------------
V
-------------------------------
N
---------------------------------------
D
F
I
V
D
--
G
N
R
I
Y
L
V
D
---------------------------------
Q
---------------------------------------
N
D
R
V
M
A
L
T
I
D
G
G
V
T
L
W
T
Q
S
D
L
L
H
R
L
L
T
S
P
V
L
-
Y
N
G
N
L
V
V
G
D
S
E
G
Y
L
H
W
I
N
V
E
D
G
R
F
V
A
Q
Q
K
-------------------------------------------
36
PsiBlast_PDB
66.06
27%
-
- C2 -
-
2YH3
-
BAMB_ECOLI
A:
[13-342]
--------------------------------
S
S
P
L
P
T
V
-
E
N
Q
F
T
P
T
T
A
-------
W
S
T
S
V
G
S
G
I
G
N
F
Y
S
N
L
H
P
A
L
A
D
N
-
V
V
Y
A
A
D
R
-
A
G
L
V
K
A
L
--
N
--
A
-------
D
DG
K
E
--
I
W
S
V
S
L
A
E
K
---------
D
GWF
S
K
E
P
AL-
L
S
------
G
-
G
--
V
T
V
--
S
----
G
G
H
V
Y
I
G
S
E
K
A
Q
V
Y
A
L
N
T
S
D
G
T
V
A
W
Q
T
K
V
A
-----
G
-----
E
-----
A
-
L
S
R
P
V
V
S
D
G
-----------
L
V
L
I
H
T
------
S
------
N
G
Q
L
Q
A
L
N
E
A
D
G
A
V
K
W
T
V
--
N
L
D
M
P
S
------
L
-
S
L
------------------------------
R
---------------------------------
G
E
S
A
P
T
T
-
A
F
G
A
A
V
-
V
G
G
D
-
N
-----------------
G
----------------
R
V
S
A
V
L
M
E
Q
G
---
Q
M
I
W
Q
Q
R
I
S
Q
A
T
G
S
T
E
I
D
R
------------------
L
S
D
V
D
T
T
P
V
------
V
V
N
---
G
V
V
F
A
L
--
A
Y
N
G
N
L
T
A
L
D
L
R
S
G
Q
I
M
---------
W
K
R
E
-
L
G
S
---------------
V
-------------------------------
N
---------------------------------------
D
F
I
V
D
--
G
N
R
I
Y
L
V
D
---------------------------------
Q
---------------------------------------
N
D
R
V
M
A
L
T
I
D
G
G
V
T
L
W
T
Q
S
D
L
L
H
R
L
L
T
S
P
V
L
-
Y
N
G
N
L
V
V
G
D
S
E
G
Y
L
H
W
I
N
V
E
D
G
R
F
V
A
Q
Q
K
-------------------------------------------
37
PsiBlast_PDB
65.58
27%
-1
- C2 -
-
5LJO
-
?
B:
[10-340]
-------------------------------
K
M
S
P
L
P
T
V
-
E
N
Q
F
T
P
T
T
A
-------
W
S
T
S
V
G
S
G
I
G
N
F
Y
S
N
L
H
P
A
L
A
D
N
-
V
V
Y
A
A
D
R
-
A
G
L
V
K
A
L
--
N
--
A
-------
D
DG
K
E
--
I
W
S
V
S
L
A
E
K
---------
D
GWFSKEPAL-
L
S
------
G
-
G
--
V
T
V
--
S
----
G
G
H
V
Y
I
G
S
E
K
A
Q
V
Y
A
L
N
T
S
D
G
T
V
A
W
Q
T
K
V
A
-----
G
-----
E
-----
A
-
L
S
R
P
V
V
S
D
G
-----------
L
V
L
I
H
T
------
S
------
N
G
Q
L
Q
A
L
N
E
A
D
G
A
V
K
W
T
V
--
N
L
D
M
P
S
------
L
-
S
L
------------------------------
R
---------------------------------
G
E
S
A
P
T
T
-
A
F
G
A
A
V
-
V
G
G
D
-
N
-----------------
G
----------------
R
V
S
A
V
L
M
E
Q
G
---
Q
M
I
W
Q
Q
R
I
S
Q
A
T
G
S
T
E
I
D
R
------------------
L
S
D
V
D
T
T
P
V
------
V
V
N
---
G
V
V
F
A
L
--
A
Y
N
G
N
L
T
A
L
D
L
R
S
G
Q
I
M
---------
W
K
R
E
-
L
G
S
---------------
V
-------------------------------
N
---------------------------------------
D
F
I
V
D
--
G
N
R
I
Y
L
V
D
---------------------------------
Q
---------------------------------------
N
D
R
V
M
A
L
T
I
D
G
G
V
T
L
W
T
Q
S
D
L
L
H
R
L
L
T
S
P
V
L
-
Y
N
G
N
L
V
V
G
D
S
E
G
Y
L
H
W
I
N
V
E
D
G
R
F
V
A
Q
Q
K
-------------------------------------------
34
PsiBlast_PDB
62.76
27%
-
- C2 -
-
5D0O
-
?
B:
[31-361]
-------------------------------
K
M
S
P
L
P
T
V
-
E
N
Q
F
T
P
T
T
A
-------
W
S
T
S
V
G
S
G
I
G
N
F
Y
S
N
L
H
P
A
L
A
D
N
-
V
V
Y
A
A
D
R
-
A
G
L
V
K
A
L
--
N
--
A
-------
D
DG
K
E
--
I
W
S
V
S
L
A
E
K
---------
D
GWF
S
K
E
P
AL-
L
S
------
G
-
G
--
V
T
V
--
S
----
G
G
H
V
Y
I
G
S
E
K
A
Q
V
Y
A
L
N
T
S
D
G
T
V
A
W
Q
T
K
V
A
-----
G
-----
E
-----
A
-
L
S
R
P
V
V
S
D
G
-----------
L
V
L
I
H
T
------
S
------
N
G
Q
L
Q
A
L
N
E
A
D
G
A
V
K
W
T
V
--
N
L
D
M
P
S
------
L
-
S
L
------------------------------
R
---------------------------------
G
E
S
A
P
T
T
-
A
F
G
A
A
V
-
V
G
G
D
-
N
-----------------
G
----------------
R
V
S
A
V
L
M
E
Q
G
---
Q
M
I
W
Q
Q
R
I
S
Q
-------
D
R
------------------
L
S
D
V
D
T
T
P
V
------
V
V
N
---
G
V
V
F
A
L
--
A
Y
N
G
N
L
T
A
L
D
L
R
S
G
Q
I
M
---------
W
K
R
E
-
L
G
S
---------------
V
-------------------------------
N
---------------------------------------
D
F
I
V
D
--
G
N
R
I
Y
L
V
D
---------------------------------
Q
---------------------------------------
N
D
R
V
M
A
L
T
I
D
G
G
V
T
L
W
T
Q
S
D
L
L
H
R
L
L
T
S
P
V
L
-
Y
N
G
N
L
V
V
G
D
S
E
G
Y
L
H
W
I
N
V
E
D
G
R
F
V
A
Q
Q
K
-------------------------------------------
40
PsiBlast_PDB
62.54
27%
-
- C2 -
-
3Q7O
-
BAMB_ECOLI
A:
[31-361]
-------------------------------
K
M
S
P
L
P
T
V
-
E
N
Q
F
T
P
T
T
A
-------
W
S
T
S
V
G
S
G
I
G
N
F
Y
S
N
L
H
P
A
L
A
D
N
-
V
V
Y
A
A
D
R
-
A
G
L
V
K
A
L
--
N
--
A
-------
D
DG
K
E
--
I
W
S
V
S
L
A
E
K
---------
D
GWFSKEPAL-
L
S
------
G
-
G
--
V
T
V
--
S
----
G
G
H
V
Y
I
G
S
E
K
A
Q
V
Y
A
L
N
T
S
D
G
T
V
A
W
Q
T
K
V
A
-----
G
-----
E
-----
A
-
L
S
R
P
V
V
S
D
G
-----------
L
V
L
I
H
T
------
S
------
N
G
Q
L
Q
A
L
N
E
A
D
G
A
V
K
W
T
V
--
N
L
D
M
P
S
------
L
-
S
L
------------------------------
R
---------------------------------
G
E
S
A
P
T
T
-
A
F
G
A
A
V
-
V
G
G
D
-
N
-----------------
G
----------------
R
V
S
A
V
L
M
E
Q
G
---
Q
M
I
W
Q
Q
R
I
S
Q
A
T
--------------------------
S
D
V
D
T
T
P
V
------
V
V
N
---
G
V
V
F
A
L
--
A
Y
N
G
N
L
T
A
L
D
L
R
S
G
Q
I
M
---------
W
K
R
E
-
L
G
S
---------------
V
-------------------------------
N
---------------------------------------
D
F
I
V
D
--
G
N
R
I
Y
L
V
D
---------------------------------
Q
---------------------------------------
N
D
R
V
M
A
L
T
I
D
G
G
V
T
L
W
T
Q
S
D
L
L
H
R
L
L
T
S
P
V
L
-
Y
N
G
N
L
V
V
G
D
S
E
G
Y
L
H
W
I
N
V
E
D
G
R
F
V
A
Q
Q
K
-------------------------------------------
35
PsiBlast_PDB
62.37
27%
12
- C2 -
-
4XGA
-
BAMA_ECOLI (first)
A:
[13-342]
--------------------------------
M
S
P
L
P
T
V
-
E
N
Q
F
T
P
T
T
A
-------
W
S
T
S
V
G
S
G
I
G
N
F
Y
S
N
L
H
P
A
L
A
D
N
-
V
V
Y
A
A
D
R
-
A
G
L
V
K
A
L
--
N
--
A
-------
D
DG
K
E
--
I
W
S
V
S
L
A
E
-----------EPAL------
L
S
------
G
-
G
--
V
T
V
--
S
----
G
G
H
V
Y
I
G
S
E
K
A
Q
V
Y
A
L
N
T
S
D
G
T
V
A
W
Q
T
K
V
A
-----
G
-----
E
-----
A
-
L
S
R
P
V
V
S
D
G
-----------
L
V
L
I
H
T
------
S
------
N
G
Q
L
Q
A
L
N
E
A
D
G
A
V
K
W
T
V
--
N
L
D
M
P
S
------
L
-
S
L
------------------------------
R
---------------------------------
G
E
S
A
P
T
T
-
A
F
G
A
A
V
-
V
G
G
D
-
N
-----------------
G
----------------
R
V
S
A
V
L
M
E
Q
G
---
Q
M
I
W
Q
Q
R
I
S
-------
I
D
R
------------------
L
S
D
V
D
T
T
P
V
------
V
V
N
---
G
V
V
F
A
L
--
A
Y
N
G
N
L
T
A
L
D
L
R
S
G
Q
I
M
---------
W
K
R
E
-
L
G
S
---------------
V
-------------------------------
N
---------------------------------------
D
F
I
V
D
--
G
N
R
I
Y
L
V
D
---------------------------------
Q
---------------------------------------
N
D
R
V
M
A
L
T
I
D
G
G
V
T
L
W
T
Q
S
D
L
L
H
R
L
L
T
S
P
V
L
-
Y
N
G
N
L
V
V
G
D
S
E
G
Y
L
H
W
I
N
V
E
D
G
R
F
V
A
Q
Q
K
-------------------------------------------
39
PsiBlast_PDB
61.24
27%
-
- C2 -
-
3Q54
-
?
A:
[31-361]
-------------------------------
K
M
S
P
L
P
T
V
-
E
N
Q
F
T
P
T
T
A
-------
W
S
T
S
V
G
S
G
I
G
N
F
Y
S
N
L
H
P
A
L
A
D
N
-
V
V
Y
A
A
D
R
-
A
G
L
V
K
A
L
--
N
--
A
-------
D
DG
K
E
--
I
W
S
V
S
L
A
E
K
---------
D
GWFSKEPAL-
L
S
------
G
-
G
--
V
T
V
--
S
----
G
G
H
V
Y
I
G
S
E
K
A
Q
V
Y
A
L
N
T
S
D
G
T
V
A
W
Q
T
K
V
A
-----
G
-----
E
-----
A
-
L
S
R
P
V
V
S
D
G
-----------
L
V
L
I
H
T
------
S
------
N
G
Q
L
Q
A
L
N
E
A
D
G
A
V
K
W
T
V
--
N
--------------
L
------------------------------
R
---------------------------------
G
E
S
A
P
T
T
-
A
F
G
A
A
V
-
V
G
G
D
-
N
-----------------
G
----------------
R
V
S
A
V
L
M
E
Q
G
---
Q
M
I
W
Q
Q
R
I
S
Q
-------
D
R
------------------
L
S
D
V
D
T
T
P
V
------
V
V
N
---
G
V
V
F
A
L
--
A
Y
N
G
N
L
T
A
L
D
L
R
S
G
Q
I
M
---------
W
K
R
E
-
L
G
S
---------------
V
-------------------------------
N
---------------------------------------
D
F
I
V
D
--
G
N
R
I
Y
L
V
D
---------------------------------
Q
---------------------------------------
N
D
R
V
M
A
L
T
I
D
G
G
V
T
L
W
T
Q
S
D
L
L
H
R
L
L
T
S
P
V
L
-
Y
N
G
N
L
V
V
G
D
S
E
G
Y
L
H
W
I
N
V
E
D
G
R
F
V
A
Q
Q
K
-------------------------------------------
31
Fugue
58.08
16%
6
- C2 -
-
4ZOX
-
SQT1_YEAST
A:
[53-431]
M
S
N
N
S
L
T
Y
F
D
K
H
T
D
S
V
F
A
I
G
H
H
P
N
L
P
L
V
C
T
G
G
G
D
N
L
A
H
L
W
T
S
H
S
Q
P
-
P
K
-------
F
A
G
T
L
T
G
Y
G
E
-
S
V
I
S
C
S
F
T
S
E
G
G
-
F
L
V
T
A
D
M
-
S
G
K
V
L
V
H
--
M
--
G
Q
KGGAQW
K
--
L
A
--
S
Q
M
Q
E
V
E
E
I
---------
V
----------
W
L
------
K
-
T
--
H
P
T
--
I
----
A
R
T
F
A
F
G
A
T
D
G
S
V
W
C
Y
Q
I
N
E
Q
D
G
S
L
E
Q
L
M
S
-----
G
-----
F
-----
V
-
H
Q
Q
D
C
S
M
G
E
F
I
NTDKGENT
L
E
L
V
T
C
S
------
L
------
D
S
T
I
V
A
W
N
C
F
T
G
Q
Q
L
F
K
I
--
T
Q
A
E
I
K
GLEAPW
I
-
S
L
------------------------------
S
---------------------------------
L
A
P
E
T
L
T
-
K
G
N
S
G
V
V
A
C
G
S
-
N
-----------------
N
----------------
G
L
L
A
V
I
N
C
N
N
GGA
I
L
H
L
S
T
V
I
E
L
K
P
E
Q
D
E
L
D
A
------------------
S
I
E
S
I
S
W
S
S
------
K
F
S
---
L
M
A
I
G
L
--
V
C
-
G
E
I
L
L
Y
D
T
S
A
W
R
V
R
---------
H
K
F
V
L
E
D
S
---------------
V
-------------------------------
T
---------------------------------------
K
L
M
F
D
--
N
D
D
L
F
A
S
C
---------------------------------
I
---------------------------------------
N
G
K
V
Y
Q
F
N
A
R
T
G
Q
-------------
E
K
F
V
C
-
V
G
H
N
M
G
V
L
D
F
I
-
L
L
H
P
V
A
N
T
G
T
E
Q
-------------------------
K
R
K
V
I
--
T
A
G
D
E
G
V
S
L
V
F
E
V
P
N-
18
HHSearch
54.42
15%
-9
- C2 -
-
4IMM
-
?
A:
[77-353]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
P
--
L
----
A
D
G
M
I
A
A
S
R
S
G
I
V
S
G
Y
M
G
--
E
S
I
A
W
Q
Y
N
A
E
-----
D
-----
V
-----
I
T
G
G
V
G
I
D
D
Q
G
S----------
V
A
V
I
G
T
------
R
------
S
G
K
L
I
A
L
D
A
R
T
G
A
A
R
W
V
V
--
E
L
A
S
S
S
---------------------------------------------------------------------------
L
A
P
A
L
I
-
S
G
D
K
-
V
I
V
I
T
N
-
S
-----------------
G
----------------
T
I
F
G
L
D
I
N
S
G
---
A
T
V
W
Q
Y
A
T
Q
V
P
N
T
-----
S
------------------
V
R
G
M
A
K
P
L
A
------
L
D
A
---
R
T
V
L
I
G
--
G
A
D
G
R
I
H
A
L
D
T
M
T
G
A
P
V
---------
W
T
R
R
-
V
G
L
AMGSGEIDQLRD---
I
D------------------------------
G
---------------------------------------
T
P
T
V
V
--
D
H
Y
L
Y
A
A
S
---------------------------------
Y
---------------------------------------
S
G
Q
L
A
G
F
D
M
T
T
G
R
T
M
F
V
S
E
L
S
S
---
T
K
K
L
T
T
-
L
A
D
A
V
I
G
S
S
T
D
G
D
V
V
A
F
N
R
M
T
G
E
K
L
W
E
N
H
D
--
L
K
Y
R
G
L-
T
N
P
V
--
T
--
I
G
T
Y
I
A
--
V
G
D
A
D
G
V
V
H
I
L
N
----
17
HHSearch
53.23
16%
-
- C2 -
-
4HDJ
-
BAMB_PSEAE
A:
[40-338]
----------------------------------------------------------------------------------------------------
V
-------
L
--
S
K
--
Q
W
S
R
S
V
G
D
G
---------
Q
GDLY------
N
L
------
L
-
E
--
P
A
V
--
D
----
G
S
T
I
Y
A
A
S
A
E
G
R
V
M
A
I
Q
R
E
T
G
D
V
L
W
K
K
D
L
E
-----
R
-----
P
-----
V
-
S
G
G
V
G
V
G
Y
G
-----------
L
V
L
V
G
T
------
L
------
R
G
D
V
I
A
L
D
E
A
T
G
K
K
K
W
T
K
--
R
V
N
S
E
V
---------------------------------------------------------------------------
L
S
A
P
A
T
-
N
G
D
V
-
V
V
V
Q
T
Q
-
D
-----------------
D
----------------
K
L
I
G
L
D
A
A
S
G
---
D
Q
R
W
I
Y
E
S
T
V
P
V
L
------------------------
T
L
R
G
T
G
A
P
L
------
I
A
G
---
N
M
A
L
A
G
--
L
A
S
G
K
V
V
A
V
D
V
Q
R
G
L
P
I
---------
W
E
Q
R
-
V
A
I
---------------
P
QGRSELD
R
V
V
D
I
D
------------------
G
---------------------------------------
G
L
L
L
S
--
G
D
T
L
Y
V
V
S
---------------------------------
Y
---------------------------------------
Q
G
R
A
A
A
L
D
V
N
S
G
R
L
L
W
Q
R
E
A
S
S
Y
---
V
G
V
A
E
-
G
F
G
N
I
Y
V
S
Q
A
S
G
S
V
E
G
L
D
S
R
G
A
S
S
L
W
N
N
D
A
--
L
A
R
R
Q
L-
S
A
P
A
--
V
--
F
S
S
N
V
V
--
V
G
D
L
E
G
Y
V
H
L
L
S
Q
---
19
HHSearch
52.87
15%
-18
- C2 -
-
4IMM
-
?
B:
[77-353]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
P
--
L
----
A
D
G
M
I
A
A
S
R
S
G
I
V
S
G
Y
M
G
---
S
I
A
W
Q
Y
N
A
E
-----
D
-----
V
-----
I
T
G
G
V
G
I
D
D
Q
G
S----------
V
A
V
I
G
T
------
R
------
S
G
K
L
I
A
L
D
A
R
T
G
A
A
R
W
V
V
--
E
L
A
S
S
S
---------------------------------------------------------------------------
L
A
P
A
L
I
-
S
G
D
K
-
V
I
V
I
T
N
-
S
-----------------
G
----------------
T
I
F
G
L
D
I
N
S
G
---
A
T
V
W
Q
Y
A
T
-----------------------------
V
R
G
M
A
K
P
L
A
------
L
D
A
---
R
T
V
L
I
G
--
G
A
D
G
R
I
H
A
L
D
T
M
T
G
A
P
V
---------
W
T
R
R
-
V
G
L
LRD------------
I
D------------------------------
G
---------------------------------------
T
P
T
V
V
--
D
H
Y
L
Y
A
A
S
---------------------------------
Y
---------------------------------------
S
G
Q
L
A
G
F
D
M
T
T
G
R
T
M
F
V
S
E
L
S
S
---
T
K
K
L
T
T
-
L
A
D
A
V
I
G
S
S
T
D
G
D
V
V
A
F
N
R
M
T
G
E
K
L
W
E
N
H
D
--
L
K
Y
R
G
L
-
T
N
P
V
--
T
--
I
G
T
Y
I
A
--
V
G
D
A
D
G
V
V
H
I
L
N
----
10
HHSearch
51.29
19%
6
- C2 -
-
4MAE
2
?
B:
[38-537]
-------------------------------------------
S
R
L
R
L
A
-------
W
S
F
S
T
G
A
L
R
---
G
H
E
G
G
P
L
V
V
G
T
-
T
M
Y
V
H
S
A
Y
P
N
H
V
Y
A
L
DL
T
--
Q
-------
K
PY
A
I
--
K
W
Q
Y
T
P
V
Q
N
---------
S
QAVAVACCDV
V
N
------
R
-
G
--
L
A
Y
--
A
----
N
G
K
I
F
M
T
T
L
D
G
Q
I
I
A
L
D
A
N
T
G
K
E
L
W
K
M
K
H
A
DVTKG
E
-----
T
-----
I
-
T
G
A
P
L
V
V
K
D
-----------
K
V
L
V
G
V
SGGEFG
V
------
R
G
R
V
G
A
Y
D
I
N
T
G
N
R
V
W
L
A
--
Y
S
Q
G
P
D
------
E
-
E
V
------------------------------
L
LDSDFNKEFPQHGGPGDGTKTWPGEQWKLGGGT
T
W
G
W
Y
S
Y
D
P
A
L
D
L
F
Y
Y
G
T
S
-
N
PGTWNAEQRKGGDNKWS
C
----------------
T
I
F
A
R
R
P
D
T
G
---
K
A
R
W
A
Y
Q
M
T
P
W
D
S
W
D
Y
D
G
V
------------------
N
E
M
I
L
P
D
L
T
------
V
K
G
KKT
P
C
L
V
H
F
--
D
R
N
G
F
G
Y
V
L
D
R
R
T
G
Q
L
I
EAQPFVYVN
W
A
K
E
-
I
S
K
---------------
E
NDRPVEIPEKRTKQGVDTKGICPNSMGGKDQ
Q
---------------------------------------
P
A
A
F
S
PQ
T
G
L
F
Y
V
P
T
---------------------------------
N
NMCMNYEGVEATYTAGAPYVGANVLMYSGHEGKDDY---
Y
G
A
F
I
C
Y
D
A
L
K
G
K
R
V
W
E
I
H
E
H
F
-
P
V
W
S
G
P
V
V
T
A
G
G
L
A
F
Y
G
T
M
D
G
W
F
K
A
V
D
I
K
T
G
K
V
L
W
Q
Q
K
L
--
G
S
G
-
I
IG
N
P
I
T
--
F
LG
P
D
K
K
Q
Y
VA
V
Y
S
G
V
G
G
W
F
G
I
A
V
---
16
HHSearch
49.10
20%
36
- C2 -
-
1W6S
3
DHM1_METEA
C:
[38-514]
-------------------------------------------
K
Q
L
R
P
A
-------
W
T
F
S
T
G
L
L
N
---
G
H
E
G
A
P
L
V
V
D
G
-
K
M
Y
I
H
T
S
F
P
N
N
T
F
A
L
G-
L
DD
P
-------
G
--
T
I
--
L
W
Q
D
K
P
K
Q
N
---------
P
AARA------
V
A
CCDLVN
R
-
G
--
L
A
Y
WP
G
DGKT
P
A
L
I
L
K
T
Q
L
D
G
N
V
A
A
L
N
A
E
T
G
E
T
V
W
K
V
E
N
S
-----
D
IKVGS
T
-----
L
-
T
I
A
P
Y
V
V
K
D
-----------
K
V
I
I
G
S
------
S
GAELGV
R
G
Y
L
T
A
Y
D
V
K
T
G
E
Q
V
W
R
A
--
Y
A
T
G
P
D
------
K
-
D
L
LLASDFNIKNPHYGQKGLGTGTWEGDAWKI
G
GGT------------------------------
N
W
G
W
Y
A
Y
D
P
G
T
N
L
I
Y
F
G
T
G
-
N
-----------------
P
APWNETMRPGDNKWTM
T
I
F
G
R
D
A
D
T
G
---
E
A
K
F
G
Y
Q
K
T
P
H
D
E
W
-----------------------
D
Y
A
G
V
N
V
M
M
LSEQKD
K
D
G
KAR
K
L
L
T
H
P
--
D
R
N
G
I
V
Y
T
L
D
R
T
D
G
A
L
V
---------
S
A
N
K
-
L
D
D
TVNVFKSVDLKTGQP
V
RDPEYGTRMDHLAKDICPSAMGYHNQ-----
G
---------------------------------------
H
D
S
Y
D
PK
R
E
L
F
F
M
G
I
---------------------------------
N
HICMDWEPFMLPYKAGQFFVGATLNMYPGPKGDRQNYEG
L
G
Q
I
K
A
Y
N
A
I
T
G
D
Y
K
W
E
K
M
E
R
F
A
V
W
G
G
T
M
A
T
-
A
G
D
L
V
F
Y
G
T
L
D
G
Y
L
K
A
R
D
S
D
T
G
D
L
L
W
K
F
K
I
--
P
S
--------------------------------------
12
HHSearch
48.85
16%
7
- C2 -
-
4MH1
1
?
B:
[46-528]
-------------------------------------------
G
Q
L
Q
L
V
-------
W
A
R
G
M
Q
P
G
K
----
V
Q
V
T
P
L
I
H
D
G
-
V
M
Y
L
A
N
P
-
G
D
V
I
Q
A
I
DA
K
--
T
-------
G
--
D
L
--
I
W
E
H
R
R
Q
L
P
NIATLNSFG
E
----------
P
T
------
R
-
G
--
M
A
L
--
Y
----
G
T
N
V
Y
F
V
S
W
D
N
H
L
V
A
L
D
M
G
T
G
Q
V
V
F
D
V
D
R
G
-----
Q
------DER
V
S
N
-
S
S
G
P
I
V
A
N
G
-----------
T
I
V
A
G
S
------
T
------
G
C
F
V
S
G
H
D
S
A
T
G
E
E
L
W
R
N
--
Y
F
I
----------W
M
T
------------------------------
G
---------------------------------
A
W
G
Q
I
T
Y
D
P
V
T
N
L
V
H
Y
G
S
-G
T
-----------------
N
----------------
T
R
F
A
V
R
P
D
T
G
---
E
I
V
W
R
H
Q
T
L
P
R
D
N
W
D
Q
E
C
T
F
E
M
M
V
T
N
V
DVQPSTEMEG
L
Q
S
I
N
P
N
A
A
------
T
G
E
---
R
R
V
L
T
G
VP
C
K
T
G
T
M
W
Q
F
D
A
E
T
G
E
F
L
---------
W
A
R
D
-
T
N
Y
---------------
Q
-------------------------------
N
MIESIDENG
I
V
T
V
N
EDAILKELD
V
E
Y
D
V
C
PTFLGGRDWP
S
A
A
L
N
PD
S
G
I
Y
F
I
P
L
N
N
V
C
Y
D
M
M
A
V
D
QEFTSMD
V
Y
N
T
S
N
V
T
K
L
P
PGKD
M
---------------------------------------
I
G
R
I
D
A
I
D
I
S
T
G
R
T
L
W
S
V
E
R
A
A
A
N
Y
S
P
V
L
S
T
-
G
G
G
V
L
F
N
G
G
T
D
R
Y
F
R
A
L
S
Q
E
T
G
E
T
L
W
Q
T
R
L
--
A
T
V
-
A
S
G
Q
A
I
S
--
Y
E
-
V
D
G
M
Q
Y
--
V
A
I
A
G
G
G
---------