@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTX8: (2017-12-15 )
MSSLIQPELFFSALSPAEQRIQQALEDIRQGKPVLVMDDFDRENEADLIVAAETLTVETMVRMIHDGSGIVCLCLTEELADHLELPPMVSQNSSQFHTAFTVTIEAAQGVTTGVSAKDRVTTIKTAIKDGAVASDLNRPGHVFPLRARNGGVLTRRGHTEGTIDLARLAGLKPAGVLCELTNPDGTMASGIQVLAYAQTHHLTVITIEELVQYRQQHGI
Atome Classification :
(35 SA)
.........10........20........30........40........50........60........70........80........90........100......-.110.......120.......130.......140.......150.......160.......170.......180.--.-..-----------.------------...190.......200.......210.......---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSSLI
Q
P
E
L
F
F
S
ALS
P
A
E
Q
R
I
Q
Q
A
L
E
D
I
RQGK
P
V
L
V
MDDFDRENEA
D
L
I
V
A
A
E
T
L
T
V
E
T
M
V
R
M
IHDGS
G
I
V
C
L
C
L
T
E
E
L
A
D
HLELPPMVSQNSS
Q
F
H
T
A
F
T
V
T
I
E
AAQ-GVTTGVSAKD
R
V
T
T
I
K
T
A
I
KDGAVASDLNRPG
H
V
F
P
L
RARNG
G
V
L
TRRGHTEG
T
I
D
L
A
R
LAGLKPA
G
V
L
C
E
LT-N--P-DG-----------
T
------------
M
AS
G
I
Q
V
L
A
Y
AQT
H
H
L
T
V
I
T
I
E
E
L
V
Q
Y
R
Q
QHGI---
50
Fugue
92.30
60%
-128
- C4 -
-
1G57
-
RIBB_ECOLI
A:
[5-213]
---------
L
L
S
S
F
G
T
P
F
E
R
V
E
N
A
L
A
A
L
R
E
G
R
G
V
M
V
L
D
----
E
N
E
G
D
M
I
F
P
A
E
T
M
T
V
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
E
D
R
R
K
Q
L
D
L
P
M
M
V
E
N
N
T
S
A
Y
G
T
G
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
I
T
T
V
R
A
A
I
A
D
G
A
K
P
S
D
L
N
R
P
G
H
V
F
P
L
R
A
Q
A
G
G
V
L
T
R
G
G
H
T
E
A
T
I
D
L
M
T
L
A
G
F
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
G
-----------
T
------------
M
A
R
A
P
E
C
I
E
F
A
N
K
H
N
M
A
L
V
T
I
E
D
L
V
A
Y
R
Q
A
H
E
----
5
PsiBlast_PDB
91.76
60%
-128
- C4 -
-
1G57
-
RIBB_ECOLI
A:
[5-212]
---------
L
L
S
S
F
G
T
P
F
E
R
V
E
N
A
L
A
A
L
R
E
G
R
G
V
M
V
L
D
----
E
N
E
G
D
M
I
F
P
A
E
T
M
T
V
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
E
D
R
R
K
Q
L
D
L
P
M
M
V
E
N
N
T
S
A
Y
G
T
G
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
I
T
T
V
R
A
A
I
A
D
G
A
K
P
S
D
L
N
R
P
G
H
V
F
P
L
R
A
Q
A
G
G
V
L
T
R
G
G
H
T
E
A
T
I
D
L
M
T
L
A
G
F
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
G
-----------
T
------------
M
A
R
A
P
E
C
I
E
F
A
N
K
H
N
M
A
L
V
T
I
E
D
L
V
A
Y
R
Q
A
H
-----
64
HHSearch
91.19
61%
-124
- C4 -
-
1G57
-
RIBB_ECOLI
A:
[9-213]
-------------
F
G
T
P
F
E
R
V
E
N
A
L
A
A
L
R
E
G
R
G
V
M
V
L
D
----
E
N
E
G
D
M
I
F
P
A
E
T
M
T
V
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
E
D
R
R
K
Q
L
D
L
P
M
M
V
E
N
N
T
S
A
Y
G
T
G
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
I
T
T
V
R
A
A
I
A
D
G
A
K
P
S
D
L
N
R
P
G
H
V
F
P
L
R
A
Q
A
G
G
V
L
T
R
G
G
H
T
E
A
T
I
D
L
M
T
L
A
G
F
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
G
-----------
T
------------
M
A
R
A
P
E
C
I
E
F
A
N
K
H
N
M
A
L
V
T
I
E
D
L
V
A
Y
R
Q
A
H
E
----
3
PsiBlast_PDB
90.36
61%
-119
- C4 -
-
3LS6
1
RIBB_SALTY
A:
[7-211]
-----------
S
S
F
G
T
P
F
E
R
V
E
L
A
L
D
A
L
R
E
G
R
G
V
M
V
L
D
D
E
D
R
E
N
E
G
D
M
I
F
P
A
E
T
M
T
V
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
E
D
R
R
K
Q
L
D
L
P
M
M
V
E
N
N
T
S
A
Y
G
T
G
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
V
T
T
V
R
A
A
I
K
D
G
A
K
P
S
D
L
N
R
P
G
H
V
F
P
L
R
A
Q
A
G
G
V
L
T
R
G
G
H
T
E
A
T
I
D
L
M
T
L
A
G
F
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
G
-----------
T
------------
M
A
R
A
P
E
C
I
A
F
A
G
Q
H
N
M
A
V
V
T
I
E
D
L
V
A
Y
R
Q
A
------
2
PsiBlast_PDB
89.97
61%
-134
- C4 -
-
3LRJ
-
RIBB_SALTY
A:
[9-212]
-------------
F
G
T
P
F
E
R
V
E
L
A
L
D
A
L
R
E
G
R
G
V
M
V
L
D
-----
N
E
G
D
M
I
F
P
A
E
T
M
T
V
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
E
D
R
R
K
Q
L
D
L
P
M
M
V
E
N
N
T
S
A
Y
G
T
G
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
V
T
T
V
R
A
A
I
K
D
G
A
K
P
S
D
L
N
R
P
G
H
V
F
P
L
R
A
Q
A
G
G
V
L
T
R
G
G
H
T
E
A
T
I
D
L
M
T
L
A
G
F
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
G
-----------
T
------------
M
A
R
A
P
E
C
I
A
F
A
G
Q
H
N
M
A
V
V
T
I
E
D
L
V
A
Y
R
Q
A
H
-----
6
PsiBlast_PDB
88.47
60%
-132
- C4 -
-
1G58
-
RIBB_ECOLI
A:
[5-212]
---------
L
L
S
S
F
G
T
P
F
E
R
V
E
N
A
L
A
A
L
R
E
G
R
G
V
M
V
L
D
-----
N
E
G
D
M
I
F
P
A
E
T
M
T
V
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
E
D
R
R
K
Q
L
D
L
P
M
M
V
E
--------
G
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
I
T
T
V
R
A
A
I
A
D
G
A
K
P
S
D
L
N
R
P
G
H
V
F
P
L
R
A
Q
A
G
G
V
L
T
R
G
G
H
T
E
A
T
I
D
L
M
T
L
A
G
F
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
G
-----------
T
------------
M
A
R
A
P
E
C
I
E
F
A
N
K
H
N
M
A
L
V
T
I
E
D
L
V
A
Y
R
Q
A
H
-----
13
PsiBlast_PDB
88.43
61%
-120
- C4 -
-
3H07
-
RIBB_YERPE
A:
[14-210]
------------------
E
R
V
E
R
A
I
D
A
L
R
N
G
R
G
V
M
V
L
D
D
E
S
R
E
N
E
G
D
M
V
F
A
A
E
A
M
T
L
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
D
E
R
R
Q
Q
L
D
L
P
M
M
V
T
H
N
S
S
Q
F
Q
T
A
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
L
T
T
I
R
K
A
I
A
D
N
A
K
P
A
D
L
N
R
P
G
H
V
F
P
L
R
G
Q
P
G
G
V
L
S
R
R
G
H
T
E
A
S
I
D
L
A
T
L
A
G
Y
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
G
-----------
S
------------
M
A
H
A
P
E
V
I
A
F
A
K
L
H
D
M
P
V
V
T
I
D
D
L
A
A
Y
L
Q
-------
48
Fugue
88.36
59%
-105
- C4 -
-
1G57
-
RIBB_ECOLI
A:
[5-213]
---------
L
L
S
S
F
G
T
P
F
E
R
V
E
N
A
L
A
A
L
R
E
G
R
G
V
M
V
L
D
----
E
N
E
G
D
M
I
F
P
A
E
T
M
T
V
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
E
D
R
R
K
Q
L
D
L
P
M
M
V
E
N
N
T
S
A
Y
G
T
G
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
I
T
T
V
R
A
A
I
A
D
G
A
K
P
S
D
L
N
R
P
G
H
V
F
P
L
R
A
Q
A
G
G
V
L
T
R
G
G
H
T
E
A
T
I
D
L
M
T
L
A
G
F
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
-------------GT----------
M
A
R
A
P
E
C
I
E
F
A
N
K
H
N
M
A
L
V
T
I
E
D
L
V
A
Y
R
Q
A
H
E
----
25
PsiBlast_CBE
88.25
61%
-123
- C4 -
-
3LQU
1
RIBB_SALTY
B:
[11-212]
---------------
T
P
F
E
R
V
E
L
A
L
D
A
L
R
E
G
R
G
V
M
V
L
D
----
E
N
E
G
D
M
I
F
P
A
E
T
M
T
V
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
E
D
R
R
K
Q
L
D
L
P
M
M
V
E
N
N
T
S
A
Y
G
T
G
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
V
T
T
V
R
A
A
I
K
D
G
A
K
P
S
D
L
N
R
P
G
H
V
F
P
L
R
A
Q
A
G
G
V
L
T
R
G
G
H
T
E
A
T
I
D
L
M
T
L
A
G
F
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
G
-----------
T
------------
M
A
R
A
P
E
C
I
A
F
A
G
Q
H
N
M
A
V
V
T
I
E
D
L
V
A
Y
R
Q
A
H
-----
1
PsiBlast_PDB
87.68
61%
-115
- C4 -
-
3LQU
1
RIBB_SALTY
A:
[8-212]
------------
S
F
G
T
P
F
E
R
V
E
L
A
L
D
A
L
R
E
G
R
G
V
M
V
L
D
D
E
D
R
E
N
E
G
D
M
I
F
P
A
E
T
M
T
V
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
E
D
R
R
K
Q
L
D
L
P
M
M
V
E
N
N
T
S
A
Y
G
T
G
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
V
T
T
V
R
A
A
I
K
D
G
A
K
P
S
D
L
N
R
P
G
H
V
F
P
L
R
A
Q
A
G
G
V
L
T
R
G
G
H
T
E
A
T
I
D
L
M
T
L
A
G
F
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
G
-----------
T
------------
M
A
R
A
P
E
C
I
A
F
A
G
Q
H
N
M
A
V
V
T
I
E
D
L
V
A
Y
R
Q
A
H
-----
58
HHSearch
87.37
60%
-112
* C4 *
-
4P6P
2
RIBB_VIBCH
B:
[29-233]
-------------
F
G
D
P
I
T
R
V
E
N
A
L
Q
A
L
R
E
G
R
G
V
L
L
L
D
D
E
D
R
E
N
E
G
D
I
I
Y
A
V
E
S
L
T
T
A
Q
M
A
L
M
I
R
E
C
S
G
I
V
C
L
C
L
T
E
A
Q
A
D
R
L
A
L
P
P
M
V
V
N
N
N
S
A
N
Q
T
A
F
T
V
S
I
E
A
K
H
-
G
V
T
T
G
V
S
A
Q
D
R
V
T
T
I
K
T
A
A
N
P
Q
A
K
P
E
D
L
A
R
P
G
H
V
F
P
L
R
A
R
A
G
G
V
L
A
R
R
G
H
T
E
G
T
V
D
L
M
Q
M
A
G
L
Q
P
A
G
V
L
C
E
L
T
-
N
--
P
-
D
G
-----------
S
------------
M
A
K
T
P
E
I
I
E
F
G
K
L
H
N
M
P
V
L
T
I
E
D
M
V
Q
Y
R
I
Q
F
D
----
49
Fugue
86.87
58%
-100
- C4 -
-
1IEZ
-
RIBB_ECOLI
A:
[1-217]
-----
M
N
Q
T
L
L
S
S
F
G
T
P
F
E
R
V
E
N
A
L
A
A
L
R
E
G
R
G
V
M
V
L
D
D
E
D
R
E
N
E
G
D
M
I
F
P
A
E
T
M
T
V
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
E
D
R
R
K
Q
L
D
L
P
M
M
V
E
N
N
T
S
A
Y
G
T
G
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
I
T
T
V
R
A
A
I
A
D
G
A
K
P
S
D
L
N
R
P
G
H
V
F
P
L
R
A
Q
A
G
G
V
L
T
R
G
G
H
T
E
A
T
I
D
L
M
T
L
A
G
F
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
G
-----------
T
------------
M
A
R
A
P
E
C
I
E
F
A
N
K
H
N
M
A
L
V
T
I
E
D
L
V
A
Y
R
Q
A
H
E
R
KAS
10
PsiBlast_PDB
86.53
62%
-119
- C4 -
-
4P77
3
RIBB_VIBCH
A:
[35-231]
-------------------
R
V
E
N
A
L
Q
A
L
R
E
G
R
G
V
L
L
L
D
D
E
D
R
E
N
E
G
D
I
I
Y
A
V
E
S
L
T
T
A
Q
M
A
L
M
I
R
E
C
S
G
I
V
C
L
C
L
T
E
A
Q
A
D
R
L
A
L
P
P
M
V
V
N
N
N
--
N
Q
T
A
F
T
V
S
I
E
A
K
H
-
G
V
T
T
G
V
S
A
Q
D
R
V
T
T
I
K
T
A
A
N
P
Q
A
K
P
E
D
L
A
R
P
G
H
V
F
P
L
R
A
R
A
G
G
V
L
A
R
R
G
H
T
E
G
T
V
D
L
M
Q
M
A
G
L
Q
P
A
G
V
L
C
E
L
T
-
N
--
P
-
D
G
-----------
S
------------
M
A
K
T
P
E
I
I
E
F
G
K
L
H
N
M
P
V
L
T
I
E
D
M
V
Q
Y
R
I
Q
------
9
PsiBlast_PDB
86.38
62%
-120
- C4 -
-
4P6P
2
RIBB_VIBCH
A:
[35-231]
-------------------
R
V
E
N
A
L
Q
A
L
R
E
G
R
G
V
L
L
L
D
D
E
D
R
E
N
E
G
D
I
I
Y
A
V
E
S
L
T
T
A
Q
M
A
L
M
I
R
E
C
S
G
I
V
C
L
C
L
T
E
A
Q
A
D
R
L
A
L
P
P
M
V
V
N
N
N
S
A
N
Q
T
A
F
T
V
S
I
E
A
K
H
-
G
V
T
T
G
V
S
A
Q
D
R
V
T
T
I
K
T
A
A
N
P
Q
A
K
P
E
D
L
A
R
P
G
H
V
F
P
L
R
A
R
A
G
G
V
L
A
R
R
G
H
T
E
G
T
V
D
L
M
Q
M
A
G
L
Q
P
A
G
V
L
C
E
L
T
-
N
--
P
-
D
G
-----------
S
------------
M
A
K
T
P
E
I
I
E
F
G
K
L
H
N
M
P
V
L
T
I
E
D
M
V
Q
Y
R
I
Q
------
4
PsiBlast_PDB
86.31
60%
-107
- C4 -
-
1IEZ
-
RIBB_ECOLI
A:
[5-212]
---------
L
L
S
S
F
G
T
P
F
E
R
V
E
N
A
L
A
A
L
R
E
G
R
G
V
M
V
L
D
D
E
D
R
E
N
E
G
D
M
I
F
P
A
E
T
M
T
V
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
E
D
R
R
K
Q
L
D
L
P
M
M
V
E
N
N
T
S
A
Y
G
T
G
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
I
T
T
V
R
A
A
I
A
D
G
A
K
P
S
D
L
N
R
P
G
H
V
F
P
L
R
A
Q
A
G
G
V
L
T
R
G
G
H
T
E
A
T
I
D
L
M
T
L
A
G
F
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
G
-----------
T
------------
M
A
R
A
P
E
C
I
E
F
A
N
K
H
N
M
A
L
V
T
I
E
D
L
V
A
Y
R
Q
A
H
-----
67
HHSearch
86.09
61%
-99
- C4 -
-
1IEZ
-
RIBB_ECOLI
A:
[7-213]
-----------
S
S
F
G
T
P
F
E
R
V
E
N
A
L
A
A
L
R
E
G
R
G
V
M
V
L
D
D
E
D
R
E
N
E
G
D
M
I
F
P
A
E
T
M
T
V
E
Q
M
A
L
T
I
R
H
G
S
G
I
V
C
L
C
I
T
E
D
R
R
K
Q
L
D
L
P
M
M
V
E
N
N
T
S
A
Y
G
T
G
F
T
V
T
I
E
A
A
E
-
G
V
T
T
G
V
S
A
A
D
R
I
T
T
V
R
A
A
I
A
D
G
A
K
P
S
D
L
N
R
P
G
H
V
F
P
L
R
A
Q
A
G
G
V
L
T
R
G
G
H
T
E
A
T
I
D
L
M
T
L
A
G
F
K
P
A
G
V
L
C
E
L
T
-
N
--
D
-
D
G
-----------
T
------------
M
A
R
A
P
E
C
I
E
F
A
N
K
H
N
M
A
L
V
T
I
E
D
L
V
A
Y
R
Q
A
H
E
----
32
PsiBlast_CBE
85.56
62%
-116
- C4 -
-
4P6C
2
RIBB_VIBCH
B:
[36-232]
-------------------
R
V
E
N
A
L
Q
A
L
R
E
G
R
G
V
L
L
L
D
D
E
D
R
E
N
E
G
D
I
I
Y
A
V
E
S
L
T
T
A
Q
M
A
L
M
I
R
E
C
S
G
I
V
C
L
C
L
T
E
A
Q
A
D
R
L
A
L
P
P
M
V
V
N
N
N
S
A
N
Q
T
A
F
T
V
S
I
E
A
K
H
-
G
V
T
T
G
V
S
A
Q
D
R
V
T
T
I
K
T
A
A
N
P
Q
A
K
P
E
D
L
A
R
P
G
H
V
F
P
L
R
A
R
A
G
G
V
L
A
R
R
G
H
T
E
G
T
V
D
L
M
Q
M
A
G
L
Q
P
A
G
V
L
C
E
L
T
-
N
--
P
-
D
G
-----------
S
------------
M
A
K
T
P
E
I
I
E
F
G
K
L
H
N
M
P
V
L
T
I
E
D
M
V
Q
Y
R
I
Q
------
7
PsiBlast_PDB
85.30
62%
-116
- C4 -
-
4P6C
2
RIBB_VIBCH
A:
[36-232]
-------------------
R
V
E
N
A
L
Q
A
L
R
E
G
R
G
V
L
L
L
D
D
E
D
R
E
N
E
G
D
I
I
Y
A
V
E
S
L
T
T
A
Q
M
A
L
M
I
R
E
C
S
G
I
V
C
L
C
L
T
E
A
Q
A
D
R
L
A
L
P
P
M
V
V
N
N
N
S
A
N
Q
T
A
F
T
V
S
I
E
A
K
H
-
G
V
T
T
G
V
S
A
Q
D
R
V
T
T
I
K
T
A
A
N
P
Q
A
K
P
E
D
L
A
R
P
G
H
V
F
P
L
R
A
R
A
G
G
V
L
A
R
R
G
H
T
E
G
T
V
D
L
M
Q
M
A
G
L
Q
P
A
G
V
L
C
E
L
T
-
N
--
P
-
D
G
-----------
S
------------
M
A
K
T
P
E
I
I
E
F
G
K
L
H
N
M
P
V
L
T
I
E
D
M
V
Q
Y
R
I
Q
------
30
PsiBlast_CBE
85.23
62%
-117
- C4 -
-
4P6P
2
RIBB_VIBCH
B:
[35-231]
-------------------
R
V
E
N
A
L
Q
A
L
R
E
G
R
G
V
L
L
L
D
D
E
D
R
E
N
E
G
D
I
I
Y
A
V
E
S
L
T
T
A
Q
M
A
L
M
I
R
E
C
S
G
I
V
C
L
C
L
T
E
A
Q
A
D
R
L
A
L
P
P
M
V
V
N
N
N
S
A
N
Q
T
A
F
T
V
S
I
E
A
K
H
-
G
V
T
T
G
V
S
A
Q
D
R
V
T
T
I
K
T
A
A
N
P
Q
A
K
P
E
D
L
A
R
P
G
H
V
F
P
L
R
A
R
A
G
G
V
L
A
R
R
G
H
T
E
G
T
V
D
L
M
Q
M
A
G
L
Q
P
A
G
V
L
C
E
L
T
-
N
--
P
-
D
G
-----------
S
------------
M
A
K
T
P
E
I
I
E
F
G
K
L
H
N
M
P
V
L
T
I
E
D
M
V
Q
Y
R
I
Q
------
28
PsiBlast_CBE
85.19
62%
-117
- C4 -
-
4P8E
6
RIBB_VIBCH
B:
[35-231]
-------------------
R
V
E
N
A
L
Q
A
L
R
E
G
R
G
V
L
L
L
D
D
E
D
R
E
N
E
G
D
I
I
Y
A
V
E
S
L
T
T
A
Q
M
A
L
M
I
R
E
C
S
G
I
V
C
L
C
L
T
E
A
Q
A
D
R
L
A
L
P
P
M
V
V
N
N
N
S
A
N
Q
T
A
F
T
V
S
I
E
A
K
H
-
G
V
T
T
G
V
S
A
Q
D
R
V
T
T
I
K
T
A
A
N
P
Q
A
K
P
E
D
L
A
R
P
G
H
V
F
P
L
R
A
R
A
G
G
V
L
A
R
R
G
H
T
E
G
T
V
D
L
M
Q
M
A
G
L
Q
P
A
G
V
L
C
E
L
T
-
N
--
P
-
D
G
-----------
S
------------
M
A
K
T
P
E
I
I
E
F
G
K
L
H
N
M
P
V
L
T
I
E
D
M
V
Q
Y
R
I
Q
------
11
PsiBlast_PDB
85.06
62%
-117
- C4 -
-
4P8E
5
RIBB_VIBCH
A:
[35-231]
-------------------
R
V
E
N
A
L
Q
A
L
R
E
G
R
G
V
L
L
L
D
D
E
D
R
E
N
E
G
D
I
I
Y
A
V
E
S
L
T
T
A
Q
M
A
L
M
I
R
E
C
S
G
I
V
C
L
C
L
T
E
A
Q
A
D
R
L
A
L
P
P
M
V
V
N
N
N
S
A
N
Q
T
A
F
T
V
S
I
E
A
K
H
-
G
V
T
T
G
V
S
A
Q
D
R
V
T
T
I
K
T
A
A
N
P
Q
A
K
P
E
D
L
A
R
P
G
H
V
F
P
L
R
A
R
A
G
G
V
L
A
R
R
G
H
T
E
G
T
V
D
L
M
Q
M
A
G
L
Q
P
A
G
V
L
C
E
L
T
-
N
--
P
-
D
G
-----------
S
------------
M
A
K
T
P
E
I
I
E
F
G
K
L
H
N
M
P
V
L
T
I
E
D
M
V
Q
Y
R
I
Q
------
8
PsiBlast_PDB
84.96
62%
-123
- C4 -
-
4P6D
1
RIBB_VIBCH
A:
[35-231]
-------------------
R
V
E
N
A
L
Q
A
L
R
E
G
R
G
V
L
L
L
D
D
E
D
R
E
N
E
G
D
I
I
Y
A
V
E
S
L
T
T
A
Q
M
A
L
M
I
R
E
C
S
G
I
V
C
L
C
L
T
E
A
Q
A
D
R
L
A
L
P
P
-------------
T
V
S
I
E
A
K
H
-
G
V
T
T
G
V
S
A
Q
D
R
V
T
T
I
K
T
A
A
N
P
Q
A
K
P
E
D
L
A
R
P
G
H
V
F
P
L
R
A
R
A
G
G
V
L
A
R
R
G
H
T
E
G
T
V
D
L
M
Q
M
A
G
L
Q
P
A
G
V
L
C
E
L
T
-
N
--
P
-
D
G
-----------
S
------------
M
A
K
T
P
E
I
I
E
F
G
K
L
H
N
M
P
V
L
T
I
E
D
M
V
Q
Y
R
I
Q
------
29
PsiBlast_CBE
84.46
62%
-123
- C4 -
-
4P77
2
RIBB_VIBCH
B:
[35-231]
-------------------
R
V
E
N
A
L
Q
A
L
R
E
G
R
G
V
L
L
L
D
D
E
D
R
E
N
E
G
D
I
I
Y
A
V
E
S
L
T
T
A
Q
M
A
L
M
I
R
E
C
S
G
I
V
C
L
C
L
T
E
A
Q
A
D
R
L
A
L
P
P
M
V
V
-------
T
A
F
T
V
S
I
E
A
K
H
-
G
V
T
T
G
V
S
A
Q
D
R
V
T
T
I
K
T
A
A
N
P
Q
A
K
P
E
D
L
A
R
P
G
H
V
F
P
L
R
A
R
A
G
G
V
L
A
R
R
G
H
T
E
G
T
V
D
L
M
Q
M
A
G
L
Q
P
A
G
V
L
C
E
L
T
-
N
--
P
-
D
G
-----------
S
------------
M
A
K
T
P
E
I
I
E
F
G
K
L
H
N
M
P
V
L
T
I
E
D
M
V
Q
Y
R
I
Q
------
61
HHSearch
83.85
44%
-125
- C4 -
-
4FFJ
5
?
A:
[2-202]
----------------
E
Y
R
K
I
Q
E
A
L
E
A
L
Q
K
G
R
L
V
L
V
I
D
D
K
D
--
N
E
G
D
L
I
C
S
A
Q
A
A
T
T
E
N
V
N
F
M
A
T
Y
A
K
G
L
I
C
M
P
M
S
E
S
L
A
N
Q
L
M
L
S
P
M
V
E
-------
T
A
F
T
V
S
I
D
Y
K
--
E
T
T
T
G
I
S
A
E
E
R
G
L
T
A
R
M
C
V
A
E
D
I
T
P
S
D
F
R
R
P
G
H
M
F
P
L
I
A
K
K
G
G
V
L
E
R
N
G
H
T
E
A
T
V
D
L
L
K
L
A
G
L
K
E
C
G
L
C
C
E
I
M
-
N
--
H
-
D
G
-----------
K
------------
M
M
R
T
D
D
L
I
Q
F
S
K
K
H
N
I
P
L
I
T
I
K
E
L
Q
E
Y
R
K
V
Y
D
----
18
PsiBlast_PDB
83.11
45%
-130
- C4 -
-
4FFJ
5
?
A:
[4-199]
------------------
R
K
I
Q
E
A
L
E
A
L
Q
K
G
R
L
V
L
V
I
D
D
K
D
--
N
E
G
D
L
I
C
S
A
Q
A
A
T
T
E
N
V
N
F
M
A
T
Y
A
K
G
L
I
C
M
P
M
S
E
S
L
A
N
Q
L
M
L
S
P
M
V
E
-------
T
A
F
T
V
S
I
D
Y
K
E
--
T
T
T
G
I
S
A
E
E
R
G
L
T
A
R
M
C
V
A
E
D
I
T
P
S
D
F
R
R
P
G
H
M
F
P
L
I
A
K
K
G
G
V
L
E
R
N
G
H
T
E
A
T
V
D
L
L
K
L
A
G
L
K
E
C
G
L
C
C
E
I
M
-
N
--
H
-
D
G
-----------
K
------------
M
M
R
T
D
D
L
I
Q
F
S
K
K
H
N
I
P
L
I
T
I
K
E
L
Q
E
Y
R
K
-------
63
HHSearch
80.14
41%
-83
- C4 -
-
1K4O
1
RIB3_MAGO7
A:
[12-224]
-----------------
F
D
A
I
P
D
V
I
Q
A
F
K
N
G
E
F
V
V
V
L
D
D
P
S
R
E
N
E
A
D
L
I
I
A
A
E
S
V
T
T
E
Q
M
A
F
M
V
R
H
S
S
G
L
I
C
A
P
L
T
P
E
R
T
T
A
L
D
L
P
Q
M
V
T
H
N
A
D
P
R
G
T
A
Y
T
V
S
V
D
A
E
H
P
S
T
T
T
G
I
S
A
H
D
R
A
L
A
C
R
M
L
A
A
P
D
A
Q
P
S
H
F
R
R
P
G
H
V
F
P
L
R
A
V
A
G
G
V
R
A
R
R
G
H
T
E
A
G
V
E
L
C
R
L
A
G
K
R
P
V
A
V
I
S
E
I
V
-
D
--
D
-
G
Q
EVEGRAVRAA
P
G
------------
M
L
R
G
D
E
C
V
A
F
A
R
R
W
G
L
K
V
C
T
I
E
D
M
I
A
H
V
E
K
T
E
----
38
PsiBlast_CBE
79.64
40%
-91
- C4 -
-
1K4O
1
RIB3_MAGO7
A:
[15-222]
--------------------
I
P
D
V
I
Q
A
F
K
N
G
E
F
V
V
V
L
D
D
P
S
R
E
N
E
A
D
L
I
I
A
A
E
S
V
T
T
E
Q
M
A
F
M
V
R
H
S
S
G
L
I
C
A
P
L
T
P
E
R
T
T
A
L
D
L
P
Q
M
V
T
H
N
A
D
P
R
G
T
A
Y
T
V
S
V
D
A
E
H
P
S
T
T
T
G
I
S
A
H
D
R
A
L
A
C
R
M
L
A
A
P
D
A
Q
P
S
H
F
R
R
P
G
H
V
F
P
L
R
A
V
A
G
G
V
R
A
R
R
G
H
T
E
A
G
V
E
L
C
R
L
A
G
K
R
P
V
A
V
I
S
E
I
V
-
D
----
D
G
-----------
Q
EVEGRAVRAA
P
G
M
L
R
G
D
E
C
V
A
F
A
R
R
W
G
L
K
V
C
T
I
E
D
M
I
A
H
V
E
K
------
36
PsiBlast_CBE
79.62
45%
-100
- C4 -
-
1TKU
1
RIB3_CANAL
B:
[8-201]
--------------------
I
E
E
A
L
E
A
Y
K
N
G
E
F
L
I
V
M
D
D
E
D
R
E
N
E
G
D
L
I
M
A
A
E
L
I
T
Q
E
K
M
A
F
L
V
R
Y
S
S
G
Y
V
C
V
P
L
S
E
E
R
A
N
Q
L
E
L
P
P
M
L
A
------
G
T
A
Y
T
I
T
C
D
F
A
E
-
G
T
T
T
G
I
S
A
H
D
R
A
L
T
T
R
S
L
A
N
P
N
S
K
P
Q
D
F
I
K
P
G
H
I
L
P
L
R
A
V
P
G
L
L
K
K
R
R
G
H
T
E
A
A
V
Q
L
S
T
L
A
G
L
Q
P
A
G
V
I
C
E
L
V
R
D
--
E
-
D
G
-----------
L
------------
M
M
R
L
D
D
C
I
Q
F
G
K
K
H
G
I
K
I
I
N
I
N
Q
L
V
E
Y
---------
60
HHSearch
79.32
44%
-94
- C4 -
-
1TKU
1
RIB3_CANAL
B:
[3-204]
---------------
N
I
F
T
P
I
E
E
A
L
E
A
Y
K
N
G
E
F
L
I
V
M
D
D
E
D
R
E
N
E
G
D
L
I
M
A
A
E
L
I
T
Q
E
K
M
A
F
L
V
R
Y
S
S
G
Y
V
C
V
P
L
S
E
E
R
A
N
Q
L
E
L
P
P
M
L
A
------
G
T
A
Y
T
I
T
C
D
F
A
E
-
G
T
T
T
G
I
S
A
H
D
R
A
L
T
T
R
S
L
A
N
P
N
S
K
P
Q
D
F
I
K
P
G
H
I
L
P
L
R
A
V
P
G
L
L
K
K
R
R
G
H
T
E
A
A
V
Q
L
S
T
L
A
G
L
Q
P
A
G
V
I
C
E
L
V
-
R
--
D
E
D
G
-----------
L
------------
M
M
R
L
D
D
C
I
Q
F
G
K
K
H
G
I
K
I
I
N
I
N
Q
L
V
E
Y
I
S
K
------
20
PsiBlast_PDB
78.59
45%
-97
- C4 -
-
1TKU
1
RIB3_CANAL
A:
[8-201]
--------------------
I
E
E
A
L
E
A
Y
K
N
G
E
F
L
I
V
M
D
D
E
D
R
E
N
E
G
D
L
I
M
A
A
E
L
I
T
Q
E
K
M
A
F
L
V
R
Y
S
S
G
Y
V
C
V
P
L
S
E
E
R
A
N
Q
L
E
L
P
P
M
L
A
------
G
T
A
Y
T
I
T
C
D
F
A
E
-
G
T
T
T
G
I
S
A
H
D
R
A
L
T
T
R
S
L
A
N
P
N
S
K
P
Q
D
F
I
K
P
G
H
I
L
P
L
R
A
V
P
G
L
L
K
K
R
R
G
H
T
E
A
A
V
Q
L
S
T
L
A
G
L
Q
P
A
G
V
I
C
E
L
V
R
D
--
E
-
D
G
-----------
L
------------
M
M
R
L
D
D
C
I
Q
F
G
K
K
H
G
I
K
I
I
N
I
N
Q
L
V
E
Y
---------
35
PsiBlast_CBE
78.47
45%
-100
- C4 -
-
2RIU
1
RIB3_CANAL
A:
[8-201]
--------------------
I
E
E
A
L
E
A
Y
K
N
G
E
F
L
I
V
M
D
D
E
D
R
E
N
E
G
D
L
I
M
A
A
E
L
I
T
Q
E
K
M
A
F
L
V
R
Y
S
S
G
Y
V
C
V
P
L
S
E
E
R
A
N
Q
L
E
L
P
P
M
L
A
------
G
T
A
Y
T
I
T
C
D
F
A
E
-
G
T
T
T
G
I
S
A
H
D
R
A
L
T
T
R
S
L
A
N
P
N
S
K
P
Q
D
F
I
K
P
G
H
I
L
P
L
R
A
V
P
G
L
L
K
K
R
R
G
H
T
E
A
A
V
Q
L
S
T
L
A
G
L
Q
P
A
G
V
I
C
E
L
V
R
D
--
E
-
D
G
-----------
L
------------
M
M
R
L
D
D
C
I
Q
F
G
K
K
H
G
I
K
I
I
N
I
N
Q
L
V
E
Y
---------
66
HHSearch
76.96
46%
-83
- C4 -
-
3MIO
2
RIBBA_MYCTA
A:
[2-206]
---------------
T
R
L
D
S
V
E
R
A
V
A
D
I
A
A
G
K
A
V
I
V
I
D
D
E
D
R
E
N
E
G
D
L
I
F
A
A
E
K
A
T
P
E
M
V
A
F
M
V
R
Y
T
S
G
Y
L
C
V
P
L
D
G
A
I
C
D
R
L
G
L
L
P
M
Y
-----------
T
V
T
V
D
A
R
N
-
G
I
G
T
G
I
S
A
S
D
R
A
T
T
M
R
L
L
A
D
P
T
S
V
A
D
D
F
T
R
P
G
H
V
V
P
L
R
A
K
D
G
G
V
L
R
R
P
G
H
T
E
A
A
V
D
L
A
R
M
A
G
L
Q
P
A
G
A
I
C
E
I
V
-
S
QK
D
-
E
G
-----------
S
------------
M
A
H
T
D
E
L
R
V
F
A
D
E
H
G
L
A
L
I
T
I
A
D
L
I
E
W
R
R
K
H
E
----
15
PsiBlast_PDB
76.72
46%
-89
- C4 -
-
3MIO
2
RIBBA_MYCTA
A:
[7-205]
--------------------
V
E
R
A
V
A
D
I
A
A
G
K
A
V
I
V
I
D
D
E
D
R
E
N
E
G
D
L
I
F
A
A
E
K
A
T
P
E
M
V
A
F
M
V
R
Y
T
S
G
Y
L
C
V
P
L
D
G
A
I
C
D
R
L
G
L
L
P
M
Y
-----------
T
V
T
V
D
A
R
N
-
G
I
G
T
G
I
S
A
S
D
R
A
T
T
M
R
L
L
A
D
P
T
S
V
A
D
D
F
T
R
P
G
H
V
V
P
L
R
A
K
D
G
G
V
L
R
R
P
G
H
T
E
A
A
V
D
L
A
R
M
A
G
L
Q
P
A
G
A
I
C
E
I
V
-
S
QK
D
-
E
G
-----------
S
------------
M
A
H
T
D
E
L
R
V
F
A
D
E
H
G
L
A
L
I
T
I
A
D
L
I
E
W
R
R
K
H
-----
65
HHSearch
76.11
46%
-84
- C4 -
-
3MIO
4
RIBBA_MYCTA
B:
[2-206]
---------------
T
R
L
D
S
V
E
R
A
V
A
D
I
A
A
G
K
A
V
I
V
I
D
D
E
D
R
E
N
E
G
D
L
I
F
A
A
E
K
A
T
P
E
M
V
A
F
M
V
R
Y
T
S
G
Y
L
C
V
P
L
D
G
A
I
C
D
R
L
G
L
L
P
M
------------
T
V
T
V
D
A
R
N
-
G
I
G
T
G
I
S
A
S
D
R
A
T
T
M
R
L
L
A
D
P
T
S
V
A
D
D
F
T
R
P
G
H
V
V
P
L
R
A
K
D
G
G
V
L
R
R
P
G
H
T
E
A
A
V
D
L
A
R
M
A
G
L
Q
P
A
G
A
I
C
E
I
V
-
S
QK
D
-
E
G
-----------
S
------------
M
A
H
T
D
E
L
R
V
F
A
D
E
H
G
L
A
L
I
T
I
A
D
L
I
E
W
R
R
K
H
E
----
33
PsiBlast_CBE
75.55
46%
-91
- C4 -
-
3MIO
4
RIBBA_MYCTA
B:
[7-205]
--------------------
V
E
R
A
V
A
D
I
A
A
G
K
A
V
I
V
I
D
D
E
D
R
E
N
E
G
D
L
I
F
A
A
E
K
A
T
P
E
M
V
A
F
M
V
R
Y
T
S
G
Y
L
C
V
P
L
D
G
A
I
C
D
R
L
G
L
L
P
M
------------
T
V
T
V
D
A
R
N
-
G
I
G
T
G
I
S
A
S
D
R
A
T
T
M
R
L
L
A
D
P
T
S
V
A
D
D
F
T
R
P
G
H
V
V
P
L
R
A
K
D
G
G
V
L
R
R
P
G
H
T
E
A
A
V
D
L
A
R
M
A
G
L
Q
P
A
G
A
I
C
E
I
V
-
S
QK
D
-
E
G
-----------
S
------------
M
A
H
T
D
E
L
R
V
F
A
D
E
H
G
L
A
L
I
T
I
A
D
L
I
E
W
R
R
K
H
-----