@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TYL3: (2017-12-15 )
MREKHYFNQDRNFWINVQQNDVLAVKNLKEEYGISDEMLTYSLDKNERARVEYDSFDEALLLVSNVPHQQKVDNHYETSPIAFILKEDGLFTFTTPNTEYVIRLIRSLLERMPDMSVYSLLFRTLFLISDSFFPLIEEVNSERQRLNLKLREKTTNKNLLQLSDLEIGLVYLVTGTKQNVVLLEQIKALAIYRKLSEKEKEELDDALIEARQAVEMTNLASQILDQLSGTYNNLLNNNLNDTMKFLTVWSLILTVPTIVTGFFGMNLQLPFTHSVFGWGIALIISLVLSIWMLIALWRRIR
Atome Classification :
(20 SA)
-------------------------------------------.........10......---..-20.-.......30........40........50........60........70........80........90....-------...---.100.......-110-.-.----.----......120.......130.......140.......150..---.....160........170...--....180.......190.---......200--.........210...-....220.......230.......240.......250.......260......-.270.......280.......290.......300
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------------MREKHYFNQDR
N
F
W
I
N
V---QQ-ND
V
-
L
A
V
K
N
L
K
E
E
YGISDE
M
L
T
Y
SLDKNE
R
A
R
VEYDS
F
D
E
A
L
L
L
V
SNVP
H
Q
Q
K
VDNHYETS
P
I
A
F
I
L
KED
G
L
F
T
F
TT-------P
N
T
---
E
Y
V
I
R
L
I
R
S
L
L
-
E
---R-M----P----D
M
S
V
Y
S
L
L
F
R
T
L
F
L
ISD
S
F
F
P
L
I
E
E
V
N
S
E
R
Q
R
L
N
L
K
L
REKT---TNKN
L
L
-
Q
L
SDL
E
I
G
L
V
Y
L
V
TG--TKQ
N
V
V
L
L
E
Q
I
K
A
L
A
I
Y
R
---
K
L
S
E
K
E
K
----
E
E
L
D
D
A
L
I
E
A
R
Q
A
V
E
-
M
T
N
L
A
S
Q
I
L
D
Q
L
S
G
T
Y
N
N
L
L
NNN
L
N
D
T
M
K
F
L
T
V
W
S
L
I
L
T
V
P
T
I
V
T
G
F
FGM
N
L
Q-LPFTH
S
V
F
G
W
G
I
A
L
I
I
S
L
V
L
S
I
W
M
L
I
A
L
W
R
RIR
2
PsiBlast_PDB
87.73
23%
-
- C3 -
-
4CY4
-
CORA_METJA
A:
[23-313]
-------------------------------------------------
F
E
D
Y
R
L
I
W
I
D
C
---
Y
D
-
P
K
D
-
E
E
L
Y
K
L
S
K
K
I
G
I
S
V
S
D
L
Q
I
G
L
D
E
Q
E
I
P
R
V
E
E
D
--
E
D
F
Y
L
I
I
Y
K
A
P
L
---
F
E
E
D
I
T
T
T
S
L
G
I
Y
I
K
N
N
L
L
L
T
I
H
S
-------
D
K
I
---
K
A
I
G
R
L
H
K
L
I
S
-
T
---
K
-
K
----
P
RIVF
E
R
G
I
G
F
L
L
Y
H
I
L
N
E
I
T
R
S
Y
S
R
I
L
M
N
L
E
D
E
L
E
E
L
E
D
K
L
L
A
G
Y
---
D
R
E
V
M
E
-
K
I
L
G
L
R
K
T
L
V
Y
F
H
K
S
L
I
A
N
R
D
V
L
V
L
L
K
R
K
Y
L
P
I
T
T
---
K
---
E
D
R
----
E
N
F
E
D
L
Y
Y
D
T
L
Q
L
I
D
-
M
S
A
T
Y
R
E
V
L
T
S
M
M
D
I
T
L
S
L
E
N
I
K
M
N
Q
I
M
K
I
L
T
M
V
T
T
I
F
A
V
P
M
W
I
T
G
I
Y
G
M
N
F
S
Y
L
P
L
A
N
N
P
Q
G
F
W
L
V
M
A
L
M
V
V
I
-
I
M
I
F
V
Y
I
F
R
R
--
22
HHSearch
80.87
22%
-
- C- -
-
4CY4
-
CORA_METJA
E:
[20-315]
----------------------------------------------
E
I
S
F
E
D
Y
R
L
I
W
I
D
C
---
Y
D
-
P
K
D
-
E
E
L
Y
K
L
S
K
K
I
G
I
S
V
S
D
L
Q
I
G
L
D
E
Q
E
I
P
R
V
E
E
D
--
E
D
F
Y
L
I
I
Y
K
A
P
L
F
E
E
---
D
I
T
T
T
S
L
G
I
Y
I
K
N
N
L
L
L
T
I
H
S
-------
D
K
I
---
K
A
I
G
R
L
H
K
L
I
S
-
T
---
K
-
K
PRIV
F
----
E
R
G
I
G
F
L
L
Y
H
I
L
N
E
I
T
R
S
Y
S
R
I
L
M
N
L
E
D
E
L
E
E
L
E
D
K
L
L
A
G
Y
----
D
R
E
V
M
E
K
I
L
G
L
R
K
T
L
V
Y
F
H
K
S
--
L
I
A
N
R
D
V
L
V
L
L
K
R
K
Y
-
L
P
---
I
T
T
K
E
D
R
----
E
N
F
E
D
L
Y
Y
D
T
L
Q
L
I
D
-
M
S
A
T
Y
R
E
V
L
T
S
M
M
D
I
T
L
S
L
E
N
I
K
M
N
Q
I
M
K
I
L
T
M
V
T
T
I
F
A
V
P
M
W
I
T
G
I
Y
G
M
N
F
S
Y
L
P
L
A
N
N
P
Q
G
F
W
L
V
M
A
L
M
V
V
I
I
M
I
F
V
Y
I
F
R
R
S
G
-
1
PsiBlast_PDB
79.46
23%
-89
- C3 -
-
4EV6
6
CORA_METJA
A:
[45-335]
-------------------------------------------------
F
E
D
Y
R
L
I
W
I
D
C
---
Y
D
-
P
K
D
-
E
E
L
Y
K
L
S
K
K
I
G
I
S
V
S
D
L
Q
I
G
L
D
E
Q
E
I
P
R
V
E
E
D
--
E
D
F
Y
L
I
I
Y
K
A
P
L
---
F
E
E
D
I
T
T
T
S
L
G
I
Y
I
K
N
N
L
L
L
T
I
H
S
-------
D
K
I
---
K
A
I
G
R
L
H
K
L
I
S
-
T
---
K
-
K
----
P
RIVF
E
R
G
I
G
F
L
L
Y
H
I
L
N
E
I
T
R
S
Y
S
R
I
L
M
N
L
E
D
E
L
E
E
L
E
D
K
L
L
A
G
Y
---
D
R
E
V
M
E
-
K
I
L
G
L
R
K
T
L
V
Y
F
H
K
S
L
I
A
N
R
D
V
L
V
L
L
K
R
K
Y
L
P
I
T
T
---
K
---
E
D
R
----
E
N
F
E
D
L
Y
Y
D
T
L
Q
L
I
D
-
M
S
A
T
Y
R
E
V
L
T
S
M
M
D
I
T
L
S
L
E
N
I
K
M
N
Q
I
M
K
I
L
T
M
V
T
T
I
F
A
V
P
M
W
I
T
G
I
Y
G
M
N
F
S
Y
L
P
L
A
N
N
P
Q
G
F
W
L
V
M
A
L
M
V
V
I
-
I
M
I
F
V
Y
I
F
R
R
--
36
Fugue
70.40
20%
-38
- C3 -
-
2HN2
-
CORA_THEMA
A:
[12-352]
----KKGLPPGTLVYTGKYRE
D
F
E
I
E
V
M
N
Y
S
IEE
F
R
E
F
K
T
TDV
E
S
V
L
P
F
R
D
S
S
T
P
T
W
I
N
I
---
T
G
I
H
R
T
-
D
V
V
Q
R
V
G
E
F
F
G
I
H
P
L
V
L
E
D
I
L
N
V
H
Q
R
P
K
V
E
F
--
F
E
N
Y
V
F
I
V
L
K
M
F
T
Y
D
K
N
L
H
E
L
E
S
E
Q
V
S
L
I
L
T
K
N
C
V
L
M
F
Q
E
-------
K
I
G
DVF
D
P
V
R
E
R
I
R
Y
N
R
-
G
---
I
-
I
----
R
----
K
K
R
A
D
Y
L
L
Y
S
L
I
D
A
L
V
D
D
Y
F
V
L
L
E
K
I
D
D
E
I
D
V
L
E
E
E
V
L
E
R
P
---
E
K
E
T
V
Q
-
R
T
H
Q
L
K
R
N
L
V
E
L
R
K
T
--
I
W
P
L
R
E
V
L
S
S
L
Y
R
D
V
-
P
P
---
L
I
E
K
E
T
V
----
P
Y
F
R
D
V
Y
D
H
T
I
Q
I
A
D
-
T
V
E
T
F
R
D
I
V
S
G
L
L
D
V
Y
L
S
S
V
S
N
K
T
N
E
V
M
K
V
L
T
I
I
A
T
I
F
M
P
L
T
F
I
A
G
I
Y
G
M
N
----------
F
G
Y
P
V
V
L
A
V
M
G
V
I
A
V
I
M
V
V
Y
F
K
K
K
K
-
21
HHSearch
69.15
19%
-16
- C3 -
-
3JCF
-
CORA_THEMA
B:
[56-350]
---------------------------------------------------
S
S
T
P
T
W
I
N
I
---
T
G
-
I
H
R
T
D
V
V
Q
R
V
G
E
F
F
G
I
H
P
L
V
L
E
D
I
L
N
V
H
Q
R
P
K
V
E
F
F
--
E
N
Y
V
F
I
V
L
K
M
F
T
Y
D
K
N
L
H
E
L
E
S
E
Q
V
S
L
I
L
T
K
N
C
V
L
M
F
Q
E
-------
K
I
G
---
D
V
F
D
P
V
R
E
R
I
R
-
Y
---
N
-
R
GII-
R
----
K
K
R
A
D
Y
L
L
Y
S
L
I
D
A
L
V
D
D
Y
F
V
L
L
E
K
I
D
D
E
I
D
V
L
E
E
E
V
L
E
R
P
---
E
-
K
E
T
V
Q
R
T
H
Q
L
K
R
N
L
V
E
L
R
K
T
--
I
W
P
L
R
E
V
L
S
S
L
Y
R
D
V
-
P
P
---
L
I
E
K
E
T
V
----
P
Y
F
R
D
V
Y
D
H
T
I
Q
I
A
D
-
T
V
E
T
F
R
D
I
V
S
G
L
L
D
V
Y
L
S
S
V
S
N
K
T
N
E
V
M
K
V
L
T
I
I
A
T
I
F
M
P
L
T
F
I
A
G
I
Y
G
M
N
F
E
Y
M
P
E
L
R
W
K
W
G
Y
P
V
V
L
A
V
M
G
V
I
A
V
I
M
V
V
Y
F
K
K
K
K
W
16
PsiBlast_PDB
69.00
22%
-75
- C3 -
-
4EGW
15
CORA_METJA
A:
[45-272]
-------------------------------------------------
F
E
D
Y
R
L
I
W
I
D
C
---
Y
D
-
P
K
D
-
E
E
L
Y
K
L
S
K
K
I
G
I
S
V
S
D
L
Q
I
G
L
D
E
Q
E
I
P
R
V
E
E
D
--
E
D
F
Y
L
I
I
Y
K
A
P
---
L
F
E
E
D
I
T
T
T
S
L
G
I
Y
I
K
N
N
L
L
L
T
I
H
S
-------
D
K
I
---
K
A
I
G
R
L
H
K
L
I
S
-
T
---
K
-
K
----
P
RIVF
E
R
G
I
G
F
L
L
Y
H
I
L
N
E
I
T
R
S
Y
S
R
I
L
M
N
L
E
D
E
L
E
E
L
E
D
K
L
L
A
G
Y
---
D
R
E
V
M
E
-
K
I
L
G
L
R
K
T
L
V
Y
F
H
K
S
L
I
A
N
R
D
V
L
V
L
L
K
R
K
Y
L
P
I
T
T
---
K
---
E
D
R
----
E
N
F
E
D
L
Y
Y
D
T
L
Q
L
I
D
-
M
S
A
T
Y
R
E
V
L
T
S
M
M
D
I
T
L
S
L
E
N
------------------------------------------------------------------
4
PsiBlast_PDB
68.26
23%
10
- C3 -
-
5JRW
-
CORA_THEMA
A:
[83-370]
--------------------------------------------------------
W
I
N
I
T
GI
H
R
-
T
D
V
---
V
Q
R
V
G
E
F
F
G
I
H
P
L
V
L
E
R
I
L
N
V
H
Q
R
P
K
V
E
F
--
F
E
N
Y
V
F
I
V
L
K
M
F
T
Y
D
K
N
L
H
E
L
E
S
E
Q
V
S
L
I
L
T
K
N
C
V
L
M
F
Q
E
KIGDVF
D
P
V
R
---
E
R
-
I
R
Y
N
R
G
I
I
R
K
---
K
-
R
----
A
----
D
Y
L
L
Y
S
L
I
D
----
A
L
V
D
D
Y
F
V
L
L
E
K
I
D
D
E
I
D
V
L
E
E
E
V
L
E
R
P
---
E
K
E
T
V
Q
-
R
T
H
Q
L
K
R
N
L
V
E
L
------
R
K
T
I
W
P
L
R
E
V
L
S
-
S
L
Y
R
DVP
P
L
I
E
K
E
T
V
P
Y
F
R
R
V
Y
D
H
T
I
Q
I
A
D
T
V
E
T
F
R
D
I
V
S
G
L
L
D
----
V
Y
L
S
S
V
S
N
K
T
N
E
V
M
K
V
L
T
I
I
A
T
I
F
M
P
L
T
F
I
A
G
I
Y
G
M
N
F
E
Y
M
P
E
L
R
W
K
W
G
Y
P
V
V
L
A
V
M
G
V
I
A
V
I
M
V
V
Y
F
K
K
K
--
7
PsiBlast_PDB
67.12
23%
5
- C3 -
-
3JCF
-
CORA_THEMA
A:
[61-348]
--------------------------------------------------------
W
I
N
I
T
GI
H
R
-
T
D
V
---
V
Q
R
V
G
E
F
F
G
I
H
P
L
V
L
E
D
I
L
N
V
H
Q
R
P
K
V
E
F
--
F
E
N
Y
V
F
I
V
L
K
M
F
T
Y
D
K
N
L
H
E
L
E
S
E
Q
V
S
L
I
L
T
K
N
C
V
L
M
F
Q
E
K
IGDVF
D
P
V
R
---
E
R
-
I
R
Y
N
R
G
I
I
R
K
---
K
-
R
----
A
----
D
Y
L
L
Y
S
L
I
D
----
A
L
V
D
D
Y
F
V
L
L
E
K
I
D
D
E
I
D
V
L
E
E
E
V
L
E
R
P
---
E
K
E
T
V
Q
-
R
T
H
Q
L
K
R
N
L
V
E
L
------
R
K
T
I
W
P
L
R
E
V
L
S
-
S
L
Y
R
D
VP
P
L
I
E
K
E
T
V
P
Y
F
R
D
V
Y
D
H
T
I
Q
I
A
D
T
V
E
T
F
R
D
I
V
S
G
L
L
D
----
V
Y
L
S
S
V
S
N
K
T
N
E
V
M
K
V
L
T
I
I
A
T
I
F
M
P
L
T
F
I
A
G
I
Y
G
M
N
F
E
Y
M
P
E
L
R
W
K
W
G
Y
P
V
V
L
A
V
M
G
V
I
A
V
I
M
V
V
Y
F
K
K
K
--
6
PsiBlast_PDB
66.85
23%
14
- C3 -
-
4I0U
1
CORA_THEMA
A:
[61-348]
--------------------------------------------------------
W
I
N
I
T
GI
H
R
-
T
D
V
---
V
Q
R
V
G
E
F
F
G
I
H
P
L
V
L
E
D
I
L
N
V
H
Q
R
P
K
V
E
F
--
F
E
N
Y
V
F
I
V
L
K
M
F
T
Y
D
K
N
L
H
E
L
E
S
E
Q
V
S
L
I
L
T
K
N
C
V
L
M
F
Q
E
KIGDVF
D
P
V
R
---
E
R
-
I
R
Y
N
R
G
I
I
R
K
---
K
-
R
----
A
----
D
Y
L
L
Y
S
L
I
D
----
A
L
V
D
D
Y
F
V
L
L
E
K
I
D
D
E
I
D
V
L
E
E
E
V
L
E
R
P
---
E
K
E
T
V
Q
-
R
T
H
Q
L
K
R
N
L
V
E
L
------
R
K
T
I
W
P
L
R
E
V
L
S
-
S
L
Y
R
DVP
P
L
I
E
K
E
T
V
P
Y
F
R
D
V
Y
D
H
T
I
Q
I
A
D
T
V
E
T
F
R
D
I
V
S
G
L
L
D
----
V
Y
L
S
S
V
S
N
K
T
N
E
V
M
K
V
L
T
I
I
A
T
I
F
M
P
L
T
F
I
A
G
I
Y
G
M
N
F
E
Y
M
P
E
L
R
W
K
W
G
Y
P
V
V
L
A
V
M
G
V
I
A
V
I
M
V
V
Y
F
K
K
K
--
10
PsiBlast_PDB
65.73
23%
19
- C3 -
-
2IUB
-
CORA_THEMA
A:
[73-360]
--------------------------------------------------------
W
I
N
I
T
GI
H
R
-
T
D
V
---
V
Q
R
V
G
E
F
F
G
I
H
P
L
V
L
E
D
I
L
N
V
H
Q
R
P
K
V
E
F
--
F
E
N
Y
V
F
I
V
L
K
M
F
T
Y
D
K
N
L
H
E
L
E
S
E
Q
V
S
L
I
L
T
K
N
C
V
L
M
F
Q
E
KIGDVF
D
P
V
R
---
E
R
-
I
R
Y
N
R
G
I
I
R
K
---
K
-
R
----
A
----
D
Y
L
L
Y
S
L
I
D
----
A
L
V
D
D
Y
F
V
L
L
E
K
I
D
D
E
I
D
V
L
E
E
E
V
L
E
R
P
---
E
K
E
T
V
Q
-
R
T
H
Q
L
K
R
N
L
V
E
L
------
R
K
T
I
W
P
L
R
E
V
L
S
-
S
L
Y
R
DVP
P
L
I
E
K
E
T
V
P
Y
F
R
D
V
Y
D
H
T
I
Q
I
A
D
T
V
E
T
F
R
D
I
V
S
G
L
L
D
----
V
Y
L
S
S
V
S
N
K
T
N
E
V
M
K
V
L
T
I
I
A
T
I
F
M
P
L
T
F
I
A
G
I
Y
--------------
G
Y
P
V
V
L
A
V
M
G
V
I
A
V
I
M
V
V
Y
F
K
K
K
--
23
HHSearch
65.36
21%
-64
- C3 -
-
4EGW
12
CORA_METJA
B:
[46-272]
--------------------------------------------------
E
D
Y
R
L
I
W
I
D
C
---
Y
D
-
P
K
D
-
E
E
L
Y
K
L
S
K
K
I
G
I
S
V
S
D
L
Q
I
G
L
D
E
Q
E
I
P
R
V
E
E
D
--
E
D
F
Y
L
I
I
Y
K
A
P
L
F
E
E
---
D
I
T
T
T
S
L
G
I
Y
I
K
N
N
L
L
L
T
I
H
S
-------
D
K
I
---
K
A
I
G
R
L
H
K
L
I
S
-
T
---
K
-
K
PRIV
F
----
E
R
G
I
G
F
L
L
Y
H
I
L
N
E
I
T
R
S
Y
S
R
I
L
M
N
L
E
D
E
L
E
E
L
E
D
K
L
L
A
G
Y
----
D
R
E
V
M
E
K
I
L
G
L
R
K
T
L
V
Y
F
H
K
S
--
L
I
A
N
R
D
V
L
V
L
L
K
R
K
Y
-
L
P
---
I
T
T
K
E
D
R
----
E
N
F
E
D
L
Y
Y
D
T
L
Q
L
I
D
-
M
S
A
T
Y
R
E
V
L
T
S
M
M
D
I
T
L
S
L
E
N
------------------------------------------------------------------
3
PsiBlast_PDB
64.99
23%
17
- C3 -
-
5JTG
-
CORA_THEMA
A:
[83-370]
--------------------------------------------------------
W
I
N
I
T
G
I
H
R
-
T
D
V
---
V
Q
R
V
G
E
F
F
G
I
H
P
L
V
L
E
K
I
L
N
V
H
Q
R
P
K
V
E
F
--
F
E
N
Y
V
F
I
V
L
K
M
F
T
Y
D
K
N
L
H
E
L
E
S
E
Q
V
S
L
I
L
T
K
N
C
V
L
M
F
Q
E
KIGDVF
D
P
V
R
---
E
R
-
I
R
Y
N
R
G
I
I
R
K
---
K
-
R
----
A
----
D
Y
L
L
Y
S
L
I
D
----
A
L
V
D
D
Y
F
V
L
L
E
K
I
D
D
E
I
D
V
L
E
E
E
V
L
E
R
P
---
E
K
E
T
V
Q
-
R
T
H
Q
L
K
R
N
L
V
E
L
------
R
K
T
I
W
P
L
R
E
V
L
S
-
S
L
Y
R
DVP
P
L
I
E
K
E
T
V
P
Y
F
R
K
V
Y
D
H
T
I
Q
I
A
D
T
V
E
T
F
R
D
I
V
S
G
L
L
D
----
V
Y
L
S
S
V
S
N
K
T
N
E
V
M
K
V
L
T
I
I
A
T
I
F
M
P
L
T
F
I
A
G
I
Y
--------------
G
Y
P
V
V
L
A
V
M
G
V
I
A
V
I
M
V
V
Y
F
K
K
K
--
37
Fugue
63.97
16%
-31
- C3 -
-
2IUB
-
CORA_THEMA
A:
[17-361]
RLSAKKGLPPGTLVYTGKYRE
D
F
E
I
E
V
M
N
Y
S
IE
E
F
R
E
F
K
T
TDV
E
S
V
L
P
F
R
D
S
S
T
P
T
W
I
N
I
---
T
G
I
H
R
T
-
D
V
V
Q
R
V
G
E
F
F
G
I
H
P
L
V
L
E
D
I
L
N
V
H
Q
R
P
K
V
E
F
F
--
E
N
Y
V
F
I
V
L
K
M
F
T
Y
D
K
N
L
H
E
L
E
S
E
Q
V
S
L
I
L
T
K
N
C
V
L
M
F
Q
E
-------
K
I
G
---
D
V
F
D
P
V
R
E
R
I
R
-
Y
NRG
I
-
I
----
R
----
K
K
R
A
D
Y
L
L
Y
S
L
I
D
A
L
V
D
D
Y
F
V
L
L
E
K
I
D
D
E
I
D
V
L
E
E
E
V
L
E
R
P
---
E
K
E
T
V
Q
-
R
T
H
Q
L
K
R
N
L
V
E
L
R
K
T
--
I
W
P
L
R
E
V
L
S
S
L
Y
R
D
V
-
P
P
---
L
I
E
K
E
T
V
----
P
Y
F
R
D
V
Y
D
H
T
I
Q
I
A
D
-
T
V
E
T
F
R
D
I
V
S
G
L
L
D
V
Y
L
S
S
V
S
N
K
T
N
E
V
M
K
V
L
T
I
I
A
T
I
F
M
P
L
T
F
I
A
G
I
Y
G
Y
P
V
V
-
L
A
V
M
G
V
I
A
V
I
M
V
V
Y
--------------
F
K
K
K
K
8
PsiBlast_PDB
63.77
23%
3
- C3 -
-
3JCG
-
CORA_THEMA
A:
[61-348]
--------------------------------------------------------
W
I
N
I
T
GI
H
R
-
T
D
V
---
V
Q
R
V
G
E
F
F
G
I
H
P
L
V
L
E
D
I
L
N
V
H
Q
R
P
K
V
E
F
--
F
E
N
Y
V
F
I
V
L
K
M
F
T
Y
D
K
N
L
H
E
L
E
S
E
Q
V
S
L
I
L
T
K
N
C
V
L
M
F
Q
E
KIGDVF
D
P
V
R
---
E
R
-
I
R
Y
N
R
G
I
I
R
K
---
K
-
R
----
A
----
D
Y
L
L
Y
S
L
I
D
----
A
L
V
D
D
Y
F
V
L
L
E
K
I
D
D
E
I
D
V
L
E
E
E
V
L
E
R
P
---
E
K
E
T
V
Q
-
R
T
H
Q
L
K
R
N
L
V
E
L
------
R
K
T
I
W
P
L
R
E
V
L
S
-
S
L
Y
R
DVP
P
L
I
E
K
E
T
V
P
Y
F
R
D
V
Y
D
H
T
I
Q
I
A
D
T
V
E
T
F
R
D
I
V
S
G
L
L
D
----
V
Y
L
S
S
V
S
N
K
T
N
E
V
M
K
V
L
T
I
I
A
T
I
F
M
P
L
T
F
I
A
G
I
Y
G
M
N
F
E
Y
M
P
E
L
R
W
K
W
G
Y
P
V
V
L
A
V
M
G
V
I
A
V
I
M
V
V
Y
F
K
K
K
--
9
PsiBlast_PDB
63.37
23%
2
- C3 -
-
3JCH
-
CORA_THEMA
A:
[61-348]
--------------------------------------------------------
W
I
N
I
T
GI
H
R
-
T
D
V
---
V
Q
R
V
G
E
F
F
G
I
H
P
L
V
L
E
D
I
L
N
V
H
Q
R
P
K
V
E
F
--
F
E
N
Y
V
F
I
V
L
K
M
F
T
Y
D
K
N
L
H
E
L
E
S
E
Q
V
S
L
I
L
T
K
N
C
V
L
M
F
Q
E
KIGDVF
D
P
V
R
---
E
R
-
I
R
Y
N
R
G
I
I
R
K
---
K
-
R
----
A
----
D
Y
L
L
Y
S
L
I
D
----
A
L
V
D
D
Y
F
V
L
L
E
K
I
D
D
E
I
D
V
L
E
E
E
V
L
E
R
P
---
E
K
E
T
V
Q
-
R
T
H
Q
L
K
R
N
L
V
E
L
------
R
K
T
I
W
P
L
R
E
V
L
S
-
S
L
Y
R
DVP
P
L
I
E
K
E
T
V
P
Y
F
R
D
V
Y
D
H
T
I
Q
I
A
D
T
V
E
T
F
R
D
I
V
S
G
L
L
D
----
V
Y
L
S
S
V
S
N
K
T
N
E
V
M
K
V
L
T
I
I
A
T
I
F
M
P
L
T
F
I
A
G
I
Y
G
M
N
F
E
Y
M
P
E
L
R
W
K
W
G
Y
P
V
V
L
A
V
M
G
V
I
A
V
I
M
V
V
Y
F
K
K
K
--
5
PsiBlast_PDB
62.87
23%
5
- C3 -
-
2BBJ
-
CORA_THEMA
A:
[61-348]
--------------------------------------------------------
W
I
N
I
T
GI
H
R
-
T
D
V
---
V
Q
R
V
G
E
F
F
G
I
H
P
L
V
L
E
D
I
L
N
V
H
Q
R
P
K
V
E
F
--
F
E
N
Y
V
F
I
V
L
K
M
F
T
Y
D
K
N
L
H
E
L
E
S
E
Q
V
S
L
I
L
T
K
N
C
V
L
M
F
Q
E
KIGDVF
D
P
V
R
---
E
R
-
I
R
Y
N
R
G
I
I
R
K
---
K
-
R
----
A
----
D
Y
L
L
Y
S
L
I
D
----
A
L
V
D
D
Y
F
V
L
L
E
K
I
D
D
E
I
D
V
L
E
E
E
V
L
E
R
P
---
E
K
E
T
V
Q
-
R
T
H
Q
L
K
R
N
L
V
E
L
------
R
K
T
I
W
P
L
R
E
V
L
S
-
S
L
Y
R
DVP
P
L
I
E
K
E
T
V
P
Y
F
R
D
V
Y
D
H
T
I
Q
I
A
D
T
V
E
T
F
R
D
I
V
S
G
L
L
D
----
V
Y
L
S
S
V
S
N
K
T
N
E
V
M
K
V
L
T
I
I
A
T
I
F
M
P
L
T
F
I
A
G
I
Y
G
M
N
F
-------
W
K
W
G
Y
P
V
V
L
A
V
M
G
V
I
A
V
I
M
V
V
Y
F
K
K
K
--
27
HHSearch
62.21
19%
-40
- C3 -
-
5N77
-
?
B:
[19-257]
-----------------------------------------------
E
S
Q
P
L
V
N
A
V
W
I
D
L
---
V
E
-
P
D
D
-
D
E
R
L
R
V
Q
S
E
L
G
Q
S
L
A
T
R
P
E
L
E
D
I
E
A
S
A
R
F
F
E
D
--
D
D
G
L
H
I
H
S
F
F
F
F
E
D
A
-
E
D
H
A
G
N
S
T
V
A
F
T
I
R
D
G
R
L
F
T
L
R
E
-------
R
E
L
---
P
A
F
R
L
Y
R
M
R
A
R
-
S
---
Q
S
M
----
V
----
D
G
N
A
Y
E
L
L
L
D
L
F
E
T
K
I
E
Q
L
A
D
E
I
E
N
I
Y
S
D
L
E
Q
L
S
R
V
I
M
E
G
H
Q
G
D
E
Y
D
E
A
L
S
T
L
A
E
L
E
D
I
G
W
K
V
R
L
C
--
L
M
D
T
Q
R
A
L
N
F
L
V
R
K
A
------
R
L
P
G
G
Q
L
----
E
Q
A
R
E
I
L
R
D
I
E
S
L
L
P
-
H
N
E
S
L
F
Q
K
V
N
F
L
M
Q
A
A
M
G
F
I
N
I
E
Q
N
R
I
I
K
----------------------------------------------------------
26
HHSearch
62.08
19%
-40
- C3 -
-
5N78
6
?
E:
[19-257]
-----------------------------------------------
E
S
Q
P
L
V
N
A
V
W
I
D
L
---
V
E
-
P
D
D
-
D
E
R
L
R
V
Q
S
E
L
G
Q
S
L
A
T
R
P
E
L
E
D
I
E
A
S
A
R
F
F
E
D
--
D
D
G
L
H
I
H
S
F
F
F
F
E
D
A
-
E
D
H
A
G
N
S
T
V
A
F
T
I
R
D
G
R
L
F
T
L
R
E
-------
R
E
L
---
P
A
F
R
L
Y
R
M
R
A
R
-
S
---
Q
S
M
----
V
----
D
G
N
A
Y
E
L
L
L
D
L
F
E
T
K
I
E
Q
L
A
D
E
I
E
N
I
Y
S
D
L
E
Q
L
S
R
V
I
M
E
G
H
QGD
E
Y
D
E
A
L
S
T
L
A
E
L
E
D
I
G
W
K
V
R
L
C
--
L
M
D
T
Q
R
A
L
N
F
L
V
R
K
A
------
R
L
P
G
G
Q
L
----
E
Q
A
R
E
I
L
R
D
I
E
S
L
L
P
-
H
N
E
S
L
F
Q
K
V
N
F
L
M
Q
A
A
M
G
F
I
N
I
E
Q
N
R
I
I
K
----------------------------------------------------------
25
HHSearch
49.57
8%
-74
- C3 -
-
3CK6
-
?
E:
[26-247]
-------------------------------------------------
E
H
I
Q
P
N
H
W
Y
H
C
---
E
R
-
L
H
P
--
D
I
R
G
W
L
E
D
N
H
V
P
R
A
T
V
D
H
L
L
A
D
E
S
R
P
S
F
H
P
L
D
-
D
D
N
F
M
L
I
L
R
G
I
N
M
N
E
N
A
S
P
E
D
M
L
S
I
R
I
L
Y
F
Q
G
A
L
I
S
T
R
K
-------
I
P
S
---
R
A
I
M
E
I
R
Q
A
L
A
-
E
---
H
-
K
----
G
----
P
K
S
L
A
S
L
L
N
Q
I
I
E
G
L
N
G
K
I
D
L
Y
L
D
T
I
E
E
T
L
N
E
F
D
V
N
--
D
-------
E
S
T
Y
N
H
I
-
A
A
Q
K
A
L
I
S
I
K
R
F
--
I
R
P
Q
Q
Y
A
I
R
D
L
I
E
S
E
-
S
E
---
L
V
T
-
S
R
P
----
H
Q
Y
R
F
A
H
N
N
I
T
R
I
N
E
-
T
I
E
F
Y
L
G
E
V
A
L
F
Q
D
E
I
K
H
N
R
D
E
K
----------------------------------------------------------------
24
HHSearch
47.97
8%
-74
- C3 -
-
3CK6
-
?
C:
[26-246]
-------------------------------------------------
E
H
I
Q
P
N
H
W
Y
H
C
---
E
R
-
L
H
P
--
D
I
R
G
W
L
E
D
N
H
V
P
R
A
T
V
D
H
L
L
A
D
E
S
R
P
S
F
H
P
L
D
-
D
D
N
F
M
L
I
L
R
G
I
N
M
N
E
N
A
S
P
E
D
M
L
S
I
R
I
L
Y
F
Q
G
A
L
I
S
T
R
K
-------
I
P
S
---
R
A
I
M
E
I
R
Q
A
L
A
-
E
---
H
-
K
----
G
----
P
K
S
L
A
S
L
L
N
Q
I
I
E
G
L
N
G
K
I
D
L
Y
L
D
T
I
E
E
T
L
N
E
F
D
V
N
--
D
-------
E
S
T
Y
N
H
I
-
A
A
Q
K
A
L
I
S
I
K
R
F
--
I
R
P
Q
Q
Y
A
I
R
D
L
I
E
S
E
-
S
E
---
L
V
T
-
S
R
P
----
H
Q
Y
R
F
A
H
N
N
I
T
R
I
N
E
-
T
I
E
F
Y
L
G
E
V
A
L
F
Q
D
E
I
K
H
N
R
D
E
-----------------------------------------------------------------