@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TZY1: (2017-12-17 )
MIKENFKRSVSRMNAFRSFQVIKEPVFHTAISDLPFTELAENEVLVKIAYSDVNYKDALAMSESGQVIRTYPMTPGIDLSGTVVQSNNPRFSKEDLVLATGFGLGVTHPGGYSQYQKVPGDWLVPLPKNMTLRQAMILGTAGFTAMLCVNALIRQGMTSDKKVVVTGASGGVGSTAIALLHKLGFQSIIAFSRKEESVTWLKSLGALQVVRPDEFLPETTKALGKQQIDYVIDTVGGEQLSSLLPLISYNGAVALCGNAGGIKLNATVLPFILRNIQLIGIDSVNVPIDQRLSLWQQMADLQIADELVVQEITLDQLPETASKLLAGTHQGRTLVNVGDHK
Atome Classification :
(20 SA)
.........10........20...------------.--------------....30-........40........50........60..----------------.-------------...----..70........80.......--.---------90........100----------------.--------------------...-...110.......120.......130.......140.......150....-.-.-.-160........170.......180.......190.......200.......210....-----------------.-.---.------------------220-.......----230.......240.......250.......260.......270.......280.......290......-.-300-...--.-..---..310-...----......320......-.330.......340
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
K
E
N
F
K
R
S
V
S
R
M
N
A
F
R
S
F
Q
V
I
K
E
------------
P
--------------
V
F
H
T
A
I-SDLP
F
T
E
LAEN
E
V
L
V
K
I
A
YSDVN
Y
K
D
ALAMSE----------------S-------------G
Q
V
----
I
R
T
YPMTPGIDL
S
G
T
V
VQSNN--P---------RFSKE
D
L
V
L
A
TGF----------------G--------------------LGV-THPGG
Y
S
Q
Y
Q
KVPG
D
W
L
VPLPKN
M
T
L
R
Q
A
M
I
LGT
A
G
F
T
A
M
L
C
V
N
A
L
I
RQG-M-T-S-D
K
-
K
V
V
V
TGASGGV
G
S
T
A
I
A
L
L
H
K
L
G
F
Q
S
I
I
A
F
SRK
E
E
S
V
T
W
L
K
SLG
A
L
Q
VVRPDEFL-----------------
P
-
E
---
T
------------------
T
K
A
-
L
G
K
Q
Q
I
D
----
Y
V
I
DTV
G
G
E
Q
L
S
S
L
L
P
L
ISYN
G
A
V
A
L
CGNAG
G
I
K
LN
A
T
V
L
P
F
I
LRN
I
Q
L
I
G
IDSVNV
P
I
D
Q
R
L
S
L
W
Q
Q
M
-
A
-
D
L
--
Q
I
A
--
D
-
E
L
---
V
V
Q
---
E
I
T
----
L
D
Q
L
P
E
T
A
S
K
L
L
AGT-HQG
R
T
L
V
NVGDHK
47
Fugue
96.23
46%
-70
- C1 -
-
1O89
-
ACUI_ECOLI
A:
[1-323]
---------------
L
Q
A
L
L
L
E
Q
Q
------------
T
----------------
L
A
S
V
-
Q
T
L
D
E
S
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
----------------
K
-------------
G
K
I
----
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
D
--
P
---------
R
F
H
A
G
Q
E
V
L
L
T
G
W
----------------
G
--------------------
V
G
E
-
N
H
W
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
-
V
-
R
-
P
-
Q
D
G
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
Q
-
V
V
A
V
S
G
R
E
S
T
H
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
F
--------------------
A
---
E
------------------
S
R
P
-
L
E
K
Q
V
W
A
----
G
A
I
D
T
V
G
D
K
V
L
A
K
V
L
A
Q
M
N
Y
G
G
C
V
A
A
C
G
L
A
G
G
F
T
L
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
P
P
E
R
R
A
Q
A
W
Q
R
L
-
V
-
A
D
LP
E
S
F
--
Y
-
T
Q
---
A
A
K
---
E
I
S
----
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
-
I
Q
G
R
T
L
V
K
V
----
1
PsiBlast_PDB
96.14
48%
-66
- C1 -
-
1O89
-
ACUI_ECOLI
A:
[16-323]
-------------------------------------------------------
S
V
-
Q
T
L
D
E
S
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
----------------
K
-------------
G
K
I
----
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
D
--
P
---------
R
F
H
A
G
Q
E
V
L
L
T
G
W
----------------
G
--------------------
V
G
E
-
N
H
W
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
-
V
-
R
P
Q
-
D
G
-
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
Q
-
V
V
A
V
S
G
R
E
S
T
H
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
F
--------------------
A
---
E
------------------
S
R
P
-
L
E
K
Q
V
W
A
----
G
A
I
D
T
V
G
D
K
V
L
A
K
V
L
A
Q
M
N
Y
G
G
C
V
A
A
C
G
L
A
G
G
F
T
L
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
P
P
E
R
R
A
Q
A
W
Q
R
L
V
A
-
D
L
P-
E
S
F
--
Y
-
T
Q
---
A
A
K
---
E
I
S
----
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
-
I
Q
G
R
T
L
V
K
V
----
3
PsiBlast_PDB
95.86
46%
-75
- C1 -
-
3NX4
2
?
A:
[15-323]
------------------------------------------------------
A
S
V
-
Q
H
L
E
E
S
Q
L
P
A
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
----------------
K
-------------
G
K
I
----
I
R
H
F
P
M
I
P
G
I
D
F
A
G
T
V
H
A
S
E
D
--
P
---------
R
F
H
A
G
Q
E
V
L
L
T
G
W
----------------
G
--------------------
V
G
E
-
N
H
W
G
G
L
A
E
R
A
R
V
K
G
D
W
L
V
A
L
P
A
G
L
S
S
R
N
A
M
I
I
G
T
A
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
-
I
-
R
P
Q
-
D
G
-
E
V
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
Q
-
V
A
A
V
S
G
R
E
S
T
H
G
Y
L
K
S
L
G
A
N
R
I
L
S
R
D
E
F
--------------------
A
---
E
------------------
S
R
P
-
L
E
K
Q
L
W
A
----
G
A
I
D
T
V
G
D
K
V
L
A
K
V
L
A
Q
M
N
Y
G
G
C
V
A
A
C
G
L
A
G
G
F
A
L
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
P
P
A
R
R
A
E
A
W
A
R
L
-
V
-
K
---
D
L
P
--
E
-
S
F
---
Y
A
Q
A
A
T
E
I
T
----
L
A
D
A
P
K
F
A
D
A
I
I
N
N
Q
-
V
Q
G
R
T
L
V
K
I
----
2
PsiBlast_PDB
95.15
48%
-63
- C1 -
-
1O8C
2
ACUI_ECOLI
A:
[37-344]
-------------------------------------------------------
S
V
-
Q
T
L
D
E
S
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
----------------
K
-------------
G
K
I
----
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
D
--
P
---------
R
F
H
A
G
Q
E
V
L
L
T
G
W
----------------
G
--------------------
V
G
E
-
N
H
W
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
-
V
-
R
P
Q
-
D
G
-
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
Q
-
V
V
A
V
S
G
R
E
S
T
H
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
F
--------------------
A
---
E
------------------
S
R
P
-
L
E
K
Q
V
W
A
----
G
A
I
D
T
V
G
D
K
V
L
A
K
V
L
A
Q
M
N
Y
G
G
C
V
A
A
C
G
L
A
G
G
F
T
L
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
P
P
E
R
R
A
Q
A
W
Q
R
L
V
A
-
D
L
P-
E
S
F
--
Y
-
T
Q
---
A
A
K
---
E
I
S
----
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
-
I
Q
G
R
T
L
V
K
V
----
21
PsiBlast_CBE
94.73
48%
-61
- C1 -
-
1O8C
2
ACUI_ECOLI
D:
[37-344]
-------------------------------------------------------
S
V
-
Q
T
L
D
E
S
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
----------------
K
-------------
G
K
I
----
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
D
--
P
---------
R
F
H
A
G
Q
E
V
L
L
T
G
W
----------------
G
--------------------
V
G
E
-
N
H
W
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
-
V
-
R
P
Q
-
D
G
-
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
Q
-
V
V
A
V
S
G
R
E
S
T
H
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
F
--------------------
A
---
E
------------------
S
R
P
-
L
E
K
Q
V
W
A
----
G
A
I
D
T
V
G
D
K
V
L
A
K
V
L
A
Q
M
N
Y
G
G
C
V
A
A
C
G
L
A
G
G
F
T
L
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
P
P
E
R
R
A
Q
A
W
Q
R
L
V
A
-
D
L
P-
E
S
F
--
Y
-
T
Q
---
A
A
K
---
E
I
S
----
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
-
I
Q
G
R
T
L
V
K
V
----
23
PsiBlast_CBE
94.62
48%
-60
- C1 -
-
1O8C
2
ACUI_ECOLI
B:
[37-344]
-------------------------------------------------------
S
V
-
Q
T
L
D
E
S
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
----------------
K
-------------
G
K
I
----
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
D
--
P
---------
R
F
H
A
G
Q
E
V
L
L
T
G
W
----------------
G
--------------------
V
G
E
-
N
H
W
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
-
V
-
R
P
Q
-
D
G
-
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
Q
-
V
V
A
V
S
G
R
E
S
T
H
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
F
--------------------
A
---
E
------------------
S
R
P
-
L
E
K
Q
V
W
A
----
G
A
I
D
T
V
G
D
K
V
L
A
K
V
L
A
Q
M
N
Y
G
G
C
V
A
A
C
G
L
A
G
G
F
T
L
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
P
P
E
R
R
A
Q
A
W
Q
R
L
V
A
-
D
L
P-
E
S
F
--
Y
-
T
Q
---
A
A
K
---
E
I
S
----
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
-
I
Q
G
R
T
L
V
K
V
----
22
PsiBlast_CBE
94.37
48%
-60
- C1 -
-
1O8C
2
ACUI_ECOLI
C:
[37-344]
-------------------------------------------------------
S
V
-
Q
T
L
D
E
S
R
L
P
E
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
----------------
K
-------------
G
K
I
----
I
R
N
F
P
M
I
P
G
I
D
F
A
G
T
V
R
T
S
E
D
--
P
---------
R
F
H
A
G
Q
E
V
L
L
T
G
W
----------------
G
--------------------
V
G
E
-
N
H
W
G
G
L
A
E
Q
A
R
V
K
G
D
W
L
V
A
M
P
Q
G
L
D
A
R
K
A
M
I
I
G
T
A
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
-
V
-
R
P
Q
-
D
G
-
E
I
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
Q
-
V
V
A
V
S
G
R
E
S
T
H
E
Y
L
K
S
L
G
A
S
R
V
L
P
R
D
E
F
--------------------
A
---
E
------------------
S
R
P
-
L
E
K
Q
V
W
A
----
G
A
I
D
T
V
G
D
K
V
L
A
K
V
L
A
Q
M
N
Y
G
G
C
V
A
A
C
G
L
A
G
G
F
T
L
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
P
P
E
R
R
A
Q
A
W
Q
R
L
V
A
-
D
L
P-
E
S
F
--
Y
-
T
Q
---
A
A
K
---
E
I
S
----
L
S
E
A
P
N
F
A
E
A
I
I
N
N
Q
-
I
Q
G
R
T
L
V
K
V
----
43
HHSearch
87.99
45%
-30
- C1 -
-
3NX4
2
?
B:
[1-323]
---------------
M
Q
A
L
I
L
E
Q
Q
------------
D
G-------------
K
T
L
A
S
V
-
Q
H
L
E
E
S
Q
L
P
A
G
D
V
T
V
D
V
H
W
S
S
L
N
Y
K
D
A
L
A
I
T
G
----------------
K
-------------
G
K
I
----
I
R
H
F
P
M
I
P
G
I
D
F
A
G
T
V
H
A
S
E
D
--
P
---------
R
F
H
A
G
Q
E
V
L
L
T
G
W
----------------
G
--------------------
V
G
E
-
N
H
W
G
G
L
A
E
R
A
R
V
K
G
D
W
L
V
A
L
P
A
G
L
S
S
R
N
A
M
I
I
G
T
A
G
F
T
A
M
L
C
V
M
A
L
E
D
A
G
I
R
-
P
-
Q
-
D
G
-
E
V
V
V
T
G
A
S
G
G
V
G
S
T
A
V
A
L
L
H
K
L
G
Y
Q
V
A
A
V
S
G
R
E
S
T
H
-
G
Y
L
K
S
L
G
A
N
R
I
L
S
R
D
E
F
A
-----------------
E
------------------------
S
R
P
-
L
E
K
Q
L
W
A
----
G
A
I
D
T
V
G
D
K
V
L
A
K
V
L
A
Q
M
N
Y
G
G
C
V
A
A
C
G
L
A
G
G
F
A
L
P
T
T
V
M
P
F
I
L
R
N
V
R
L
Q
G
V
D
S
V
M
T
P
P
A
R
R
A
E
A
W
A
R
L
-
V
-
K
D
--
L
P
E
SF
Y
-
A
Q
---
A
A
T
---
E
I
T
----
L
A
D
A
P
K
F
A
D
A
I
I
N
N
Q
-
V
Q
G
R
T
L
V
K
I
----
6
PsiBlast_PDB
87.93
45%
-53
- C1 -
-
4JXK
2
?
A:
[50-349]
-----------------------------------------------------------------
L
P
Q
G
E
V
T
I
Q
V
E
Y
S
S
V
N
F
K
D
A
L
A
L
T
P
----------------
K
-------------
G
G
V
----
V
R
E
Y
P
I
V
P
G
I
D
V
A
G
T
V
V
E
S
Q
S
--
P
---------
E
F
S
V
G
D
T
V
V
A
H
G
Y
----------------
D
--------------------
I
G
T
-
A
R
H
G
G
Y
A
Q
F
A
R
V
P
A
D
W
V
V
K
L
-
D
G
M
S
T
R
T
A
A
A
I
G
T
A
G
F
T
A
A
M
S
V
E
A
L
Q
S
R
G
-
V
-
E
P
G
-
N
G
-
P
V
L
V
T
G
A
S
G
G
V
G
T
V
A
V
D
L
L
S
A
A
G
F
E
-
V
V
A
S
S
G
K
P
E
K
A
E
L
L
T
Q
L
G
A
S
K
V
I
---
G
R
L
-----------------
P
-
E
PDT
K
------------------
P
R
P
-
L
G
K
A
Q
W
A
----
A
A
V
D
C
V
G
G
A
T
L
A
H
V
L
S
T
I
E
Y
G
G
A
V
A
A
S
G
L
T
G
G
P
K
L
E
T
T
V
L
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Q
Y
P
I
D
Q
R
R
R
L
W
G
R
L
-
A
S
D
L
--
A
P
S
--
R
L
E
S
---
I
T
H
---
D
V
P
----
I
A
D
V
V
S
V
I
D
Q
V
R
A
G
T
-
Y
S
G
R
A
V
V
A
V
----
5
PsiBlast_PDB
87.92
45%
-48
- C1 -
-
1Y9E
2
YHFP_BACSU
A:
[28-330]
----------------------------------------------------------------
D
L
P
K
D
G
V
L
I
K
V
A
Y
S
G
I
N
Y
K
D
G
L
A
G
K
A
----------------
G
-------------
G
N
I
----
V
R
E
Y
P
L
I
L
G
I
D
A
A
G
T
V
V
S
S
N
D
--
P
---------
R
F
A
E
G
D
E
V
I
A
T
S
Y
----------------
E
--------------------
L
G
V
-
S
R
D
G
G
L
S
E
Y
A
S
V
P
G
D
W
L
V
P
L
P
Q
N
L
S
L
K
E
A
M
V
Y
G
T
A
G
F
T
A
A
L
S
V
H
R
L
E
Q
N
G
-
L
-
S
-
P
-
E
K
G
S
V
L
V
T
G
A
T
G
G
V
G
G
I
A
V
S
M
L
N
K
R
G
Y
D
-
V
V
A
S
T
G
N
R
E
A
A
D
Y
L
K
Q
L
G
A
S
E
V
I
S
R
E
D
V
Y
-----------------
D
-
G
---
T
------------------
L
K
A
-
L
S
K
Q
Q
W
Q
----
G
A
V
D
P
V
G
G
K
Q
L
A
S
L
L
S
K
I
Q
Y
G
G
S
V
A
V
S
G
L
T
G
G
G
E
V
P
A
T
V
Y
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Y
C
P
M
D
V
R
A
A
V
W
E
R
M
-
S
-
S
D
--
L
K
P
--
D
-
Q
L
LTI
V
D
R
---
E
V
S
----
L
E
E
T
P
G
A
L
K
D
I
L
Q
N
R
-
I
Q
G
R
V
I
V
K
L
----
24
PsiBlast_CBE
87.86
45%
-51
- C1 -
-
4JXK
1
?
B:
[50-349]
-----------------------------------------------------------------
L
P
Q
G
E
V
T
I
Q
V
E
Y
S
S
V
N
F
K
D
A
L
A
L
T
P
----------------
K
-------------
G
G
V
----
V
R
E
Y
P
I
V
P
G
I
D
V
A
G
T
V
V
E
S
Q
S
--
P
---------
E
F
S
V
G
D
T
V
V
A
H
G
Y
----------------
D
--------------------
I
G
T
-
A
R
H
G
G
Y
A
Q
F
A
R
V
P
A
D
W
V
V
K
L
-
D
G
M
S
T
R
T
A
A
A
I
G
T
A
G
F
T
A
A
M
S
V
E
A
L
Q
S
R
G
-
V
-
E
P
G
-
N
G
-
P
V
L
V
T
G
A
S
G
G
V
G
T
V
A
V
D
L
L
S
A
A
G
F
E
-
V
V
A
S
S
G
K
P
E
K
A
E
L
L
T
Q
L
G
A
S
K
V
I
---
G
R
L
-----------------
P
-
E
PDT
K
------------------
P
R
P
-
L
G
K
A
Q
W
A
----
A
A
V
D
C
V
G
G
A
T
L
A
H
V
L
S
T
I
E
Y
G
G
A
V
A
A
S
G
L
T
G
G
P
K
L
E
T
T
V
L
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Q
Y
P
I
D
Q
R
R
R
L
W
G
R
L
-
A
S
D
L
--
A
P
S
--
R
L
E
S
---
I
T
H
---
D
V
P
----
I
A
D
V
V
S
V
I
D
Q
V
R
A
G
T
-
Y
S
G
R
A
V
V
A
V
----
30
HHSearch
85.87
40%
-29
- C1 -
-
4JXK
2
?
A:
[25-350]
--------------
E
F
T
A
W
I
A
R
E
N
------------
E
G-------------
A
I
G
L
S
Q
-
E
T
V
G
E
S
F
L
P
Q
G
E
V
T
I
Q
V
E
Y
S
S
V
N
F
K
D
A
L
A
L
T
P
----------------
K
-------------
G
G
V
----
V
R
E
Y
P
I
V
P
G
I
D
V
A
G
T
V
V
E
S
Q
S
--
P
---------
E
F
S
V
G
D
T
V
V
A
H
G
Y
----------------
D
--------------------
I
G
T
-
A
R
H
G
G
Y
A
Q
F
A
R
V
P
A
D
W
V
V
K
L
-
D
G
M
S
T
R
T
A
A
A
I
G
T
A
G
F
T
A
A
M
S
V
E
A
L
Q
S
R
G
-
V
-
E
-
P
G
N
G
-
P
V
L
V
T
G
A
S
G
G
V
G
T
V
A
V
D
L
L
S
A
A
G
F
E
V
V
A
S
S
G
K
P
E
K
A
-
E
L
L
T
Q
L
G
A
S
K
V
I
G
R
L
P
E
P
-----------------
D
-
T
---
K
------------------
P
R
P
-
L
G
K
A
Q
W
A
----
A
A
V
D
C
V
G
G
A
T
L
A
H
V
L
S
T
I
E
Y
G
G
A
V
A
A
S
G
L
T
G
G
P
K
L
E
T
T
V
L
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Q
Y
P
I
D
Q
R
R
R
L
W
G
R
L
-
A
-
S
D
--
L
A
P
SR
L
-
E
S
---
I
T
H
---
D
V
P
----
I
A
D
V
V
S
V
I
D
Q
V
R
A
G
T
-
Y
S
G
R
A
V
V
A
V
A
---
41
HHSearch
83.98
43%
-19
- C1 -
-
1Y9E
2
YHFP_BACSU
F:
[2-330]
------------
S
T
L
F
Q
A
L
Q
A
E
K
N
------------
A
D-------------
D
V
S
V
H
V
-
K
T
I
S
T
E
D
L
P
K
D
G
V
L
I
K
V
A
Y
S
G
I
N
Y
K
D
G
L
A
G
K
A
----------------
G
-------------
G
N
I
----
V
R
E
Y
P
L
I
L
G
I
D
A
A
G
T
V
V
S
S
N
D
--
P
---------
R
F
A
E
G
D
E
V
I
A
T
S
Y
----------------
E
--------------------
L
G
V
-
S
R
D
G
G
L
S
E
Y
A
S
V
P
G
D
W
L
V
P
L
P
Q
N
L
S
L
K
E
A
M
V
Y
G
T
A
G
F
T
A
A
L
S
V
H
R
L
E
Q
N
G
-
L
S
P
-
E
-
K
G
-
S
V
L
V
T
G
A
T
G
G
V
G
G
I
A
V
S
M
L
N
K
R
G
Y
D
V
V
A
S
T
G
N
R
E
A
A
-
D
Y
L
K
Q
L
G
A
S
E
V
I
S
R
E
D
V
Y
-----------------
D
-
G
---
T
------------------
L
K
A
-
L
S
K
Q
Q
W
Q
----
G
A
V
D
P
V
G
G
K
Q
L
A
S
L
L
S
K
I
Q
Y
G
G
S
V
A
V
S
G
L
T
G
G
G
E
V
P
A
T
V
Y
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Y
C
P
M
D
V
R
A
A
V
W
E
R
M
-
S
-
S
D
--
L
K
P
DQ
L
-
L
T
I--
V
D
R
---
E
V
S
----
L
E
E
T
P
G
A
L
K
D
I
L
Q
N
R
-
I
Q
G
R
V
I
V
K
L
----
28
HHSearch
67.88
21%
-22
- C1 -
-
3KRT
-
?
A:
[22-420]
------
I
A
A
L
P
L
P
E
S
Y
R
A
I
T
V
H
K
D
------------
E
TEMFAGLETRDKDP
R
K
S
I
H
L
-
D
D
V
P
V
P
E
L
G
P
G
E
A
L
V
A
V
M
A
S
S
V
N
Y
N
S
V
H
T
S
I
F
----------------
E
PLST
F
G
F
L
E
R
Y
G
R
V
S
D
LAKR
H
D
L
P
Y
H
V
I
G
S
D
L
A
G
V
V
L
R
T
G
P
GV
N
---------
A
W
Q
A
G
D
E
V
V
A
H
C
L
----------------
S
VELESSDGHNDTMLDPEQRI
W
G
F
E
T
N
F
G
G
L
A
E
I
A
L
V
K
S
N
Q
L
M
P
K
P
D
H
L
S
W
E
E
A
A
A
P
G
L
V
N
S
T
A
Y
R
Q
L
V
S
R
N
G
A
G
-
M
-
K
-
Q
-
G
D
-
N
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
T
Q
F
A
L
A
G
G
A
N
P
I
C
V
V
S
S
P
Q
K
A
-
E
I
C
R
A
M
G
A
E
A
I
I
D
R
N
A
E
G
YRFWKDENTQD
P
K
E
W
K
R
F
G
K
---
R
------------------
I
R
E
L
T
G
G
E
D
I
D
----
I
V
F
E
H
P
G
R
E
T
F
G
A
S
V
F
V
T
R
K
G
G
T
I
T
T
C
A
S
T
S
G
Y
M
H
E
Y
D
N
R
Y
L
W
M
S
L
K
R
I
I
G
S
H
F
A
N
------
Y
R
E
A
W
E
A
-
N
-
R
L
--
I
A
K
GR
I
-
H
P
T--
L
S
K
---
V
Y
S
----
L
E
D
T
G
Q
A
A
Y
D
V
H
R
N
L
-
H
Q
G
K
V
G
V
L
-----
27
HHSearch
67.17
21%
-22
- C1 -
-
3KRT
-
?
D:
[22-420]
------
I
A
A
L
P
L
P
E
S
Y
R
A
I
T
V
H
K
D
------------
E
TEMFAGLETRDKDP
R
K
S
I
H
L
-
D
D
V
P
V
P
E
L
G
P
G
E
A
L
V
A
V
M
A
S
S
V
N
Y
N
S
V
H
T
S
I
F
----------------
E
PLSTFGFLERYGR
V
S
D
LAKR
H
D
L
P
Y
H
V
I
G
S
D
L
A
G
V
V
L
R
T
G
P
GV
N
---------
A
W
Q
A
G
D
E
V
V
A
H
C
L
----------------
S
VELESSDGHNDTMLDPEQRI
W
G
F
E
T
N
F
G
G
L
A
E
I
A
L
V
K
S
N
Q
L
M
P
K
P
D
H
L
S
W
E
E
A
A
A
P
G
L
V
N
S
T
A
Y
R
Q
L
V
S
R
N
G
A
G
-
M
-
K
-
Q
-
G
D
-
N
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
T
Q
F
A
L
A
G
G
A
N
P
I
C
V
V
S
S
P
Q
K
A
-
E
I
C
R
A
M
G
A
E
A
I
I
D
R
N
A
E
G
YRFWKDENTQDPKEWKR
F
G
K
---
R
------------------
I
R
E
L
T
G
G
E
D
I
D
----
I
V
F
E
H
P
G
R
E
T
F
G
A
S
V
F
V
T
R
K
G
G
T
I
T
T
C
A
S
T
S
G
Y
M
H
E
Y
D
N
R
Y
L
W
M
S
L
K
R
I
I
G
S
H
F
A
N
------
Y
R
E
A
W
E
A
-
N
-
R
L
--
I
A
K
GR
I
-
H
P
T--
L
S
K
---
V
Y
S
----
L
E
D
T
G
Q
A
A
Y
D
V
H
R
N
L
-
H
Q
G
K
V
G
V
L
-----
34
HHSearch
65.84
20%
-14
- C1 -
-
4A0S
4
?
C:
[20-415]
----------
P
V
P
D
T
Y
L
A
L
H
L
R
A
E
DADMFKGVADKD
V
--------------
R
K
S
L
R
L
-
G
E
V
P
M
P
E
L
A
P
D
E
V
L
V
A
V
M
A
S
S
I
N
Y
N
T
V
W
S
A
M
F
EPIPTFHFLKQNARQG
G
-------------
W
A
T
R---
H
D
Q
P
Y
H
V
L
G
S
D
C
S
G
V
V
V
R
T
G
I
GV
R
---------
R
W
K
P
G
D
H
V
I
V
H
P
A
----------------
H
VDEQEPATHGDGMLGTEQRA
W
G
F
E
T
N
F
G
G
L
A
E
Y
G
V
V
R
A
S
Q
L
L
P
K
P
A
H
L
T
W
E
E
A
A
V
S
P
L
C
A
G
T
A
Y
R
M
L
V
S
D
R
G
A
Q
-
M
-
K
-
Q
-
G
D
-
I
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
I
Q
F
V
K
N
G
G
G
I
P
V
A
V
V
S
S
A
Q
K
E
-
A
A
V
R
A
L
G
C
D
L
V
I
N
R
A
E
L
G
-----------------
I
-
T
D--
D
IADDPRRVVETGRKLAKL
V
V
E
-
K
A
G
R
E
P
D
----
I
V
F
E
H
T
G
R
V
T
F
G
L
S
V
I
V
A
R
R
G
G
T
V
V
T
C
G
S
S
S
G
Y
L
H
T
F
D
N
R
Y
L
W
M
K
L
K
K
I
V
G
S
H
G
A
--
N
----
H
E
E
Q
Q
A
T
-
N
-
R
L
--
F
E
S
GA
V
-
V
P
A--
M
S
A
---
V
Y
P
----
L
A
E
A
A
E
A
C
R
V
V
Q
T
S
R
-
Q
V
G
K
V
A
V
L
C
M
A
--
33
HHSearch
65.00
20%
-15
- C1 -
-
4A0S
4
?
B:
[20-415]
----------
P
V
P
D
T
Y
L
A
L
H
L
R
A
E
DADMFKGVADKD
V
--------------
R
K
S
L
R
L
-
G
E
V
P
M
P
E
L
A
P
D
E
V
L
V
A
V
M
A
S
S
I
N
Y
N
T
V
W
S
A
M
F
EPIPTFHFLKQNARQG
G
-------------
W
A
T
R---
H
D
Q
P
Y
H
V
L
G
S
D
C
S
G
V
V
V
R
T
G
I
GV
R
---------
R
W
K
P
G
D
H
V
I
V
H
P
A
----------------
H
VDEQEPATHGDGMLGTEQRA
W
G
F
E
T
N
F
G
G
L
A
E
Y
G
V
V
R
A
S
Q
L
L
P
K
P
A
H
L
T
W
E
E
A
A
V
S
P
L
C
A
G
T
A
Y
R
M
L
V
S
D
R
G
A
Q
-
M
-
K
-
Q
-
G
D
-
I
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
I
Q
F
V
K
N
G
G
G
I
P
V
A
V
V
S
S
A
Q
K
E
-
A
A
V
R
A
L
G
C
D
L
V
I
N
R
A
E
L
G
-----------------
I
-
T
D--
D
IADDPRRVVETGRKLAKL
V
V
E
-
K
A
G
R
E
P
D
----
I
V
F
E
H
T
G
R
V
T
F
G
L
S
V
I
V
A
R
R
G
G
T
V
V
T
C
G
S
S
S
G
Y
L
H
T
F
D
N
R
Y
L
W
M
K
L
K
K
I
V
G
S
H
G
A
--
N
----
H
E
E
Q
Q
A
T
-
N
-
R
L
--
F
E
S
GA
V
-
V
P
A--
M
S
A
---
V
Y
P
----
L
A
E
A
A
E
A
C
R
V
V
Q
T
S
R
-
Q
V
G
K
V
A
V
L
C
M
A
--
16
PsiBlast_PDB
64.02
24%
-10
- C1 -
-
3PII
2
ADH3_GEOSE
A:
[10-337]
----------------------
K
E
------------
P
--------------
L
---
K
I
-
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
G
----------------
D
-------------
W
P
V
----
K
P
K
L
P
L
I
P
G
H
E
G
V
G
-
I
V
E
E
V
G
--
P
GVTHLKVG
D
R
V
G
I
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
GQETLCEH
Q
K
N
--------------------
A
G
Y
-
S
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
---
K
A
L
K
V
T
G
-
A
-
K
-
P
-
G
E
-
W
V
A
I
Y
G
I
-
G
G
F
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
---
L
-----------------
K
-
E
---
D
------------------
A
A
K
-
F
M
K
E
K
V
G
GVH
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
------
L
P
P
E
E
M
P
I
P
I
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
-----
L
--
Q
F
A
--
A
-
E
G
---
K
V
K
---
T
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
-
I
N
G
R
V
V
L
T
L
E
---
39
HHSearch
62.09
21%
-2
- C1 -
-
1YB5
5
QOR_HUMAN
A:
[28-351]
-------------
K
L
M
R
A
V
R
V
F
E
F
------------
G
G
-------------
P
E
V
L
K
L
R
S
D
I
A
V
P
I
P
K
D
H
Q
V
L
I
K
V
H
A
C
G
V
N
P
V
E
T
Y
I
R
S
G
----------------
T
-------------
Y
S
R
----
K
P
L
L
P
Y
T
P
G
S
D
V
A
G
V
I
E
A
V
G
D
NA
S
---------
A
F
K
K
G
D
R
V
F
T
S
S
T
------------------------------------------
I
S
G
G
Y
A
E
Y
A
L
A
A
D
H
T
V
Y
K
L
P
E
K
L
D
F
K
Q
G
A
A
I
G
I
P
Y
F
T
A
Y
R
A
L
I
H
S
A
C
---
V
-
K
-
A
-
G
E
-
S
V
L
V
H
G
A
S
G
G
V
G
L
A
A
C
Q
I
A
R
A
Y
G
L
K
I
L
G
T
A
G
T
E
E
G
Q
-
K
I
V
L
Q
N
G
A
H
E
V
F
N
H
R
E
V
N
-----------------
Y
-
I
D
--
K
------------------
I
K
K
Y
V
G
E
K
G
I
D
----
I
I
I
E
M
L
A
N
V
N
L
S
K
D
L
S
L
L
S
H
G
G
R
V
I
V
V
G
S
R
G
T
I
E
I
--
N
P
R
D
T
M
A
K
E
S
S
I
I
G
V
T
L
F
S
S
T
K
E
E
F
Q
Q
Y
A
A
A
L
-
Q
-
A
G
--
M
E
I
GW
L
-
K
P
V
--
I
G
S
---
Q
Y
P
----
L
E
K
V
A
E
A
H
E
N
I
I
H
G
S
G
A
T
G
K
M
I
L
L
L
----
4
PsiBlast_PDB
60.04
45%
-27
- C1 -
-
1TT7
-
YHFP_BACSU
A:
[28-330]
----------------------------------------------------------------
D
L
P
K
D
G
V
L
I
K
V
A
Y
S
G
I
N
Y
K
D
G
L
A
G
K
A
----------------
G
-------------
G
N
I
----
V
R
E
Y
P
L
I
L
G
I
D
A
A
G
T
V
V
S
S
N
D
--
P
---------
R
F
A
E
G
D
E
V
I
A
T
S
Y
----------------
E
--------------------
L
G
V
-
S
R
D
G
G
L
S
E
Y
A
S
V
P
G
D
W
L
V
P
L
P
Q
N
L
S
L
K
E
A
M
V
Y
G
T
A
G
F
T
A
A
L
S
V
H
R
L
E
Q
N
G
-
L
-
S
-
P
-
E
K
G
S
V
L
V
T
G
A
T
G
G
V
G
G
I
A
V
S
M
L
N
K
R
G
Y
D
-
V
V
A
S
T
G
N
R
E
A
A
D
Y
L
K
Q
L
G
A
S
E
V
I
S
R
E
D
V
Y
-----------------
D
-
G
---
T
------------------
L
K
A
-
L
S
K
Q
Q
W
Q
----
G
A
V
D
P
V
G
G
K
Q
L
A
S
L
L
S
K
I
Q
Y
G
G
S
V
A
V
S
G
L
T
G
G
G
E
V
P
A
T
V
Y
P
F
I
L
R
G
V
S
L
L
G
I
D
S
V
Y
C
P
M
D
V
R
A
A
V
W
E
R
M
-
S
-
S
D
--
L
K
P
--
D
-
Q
L
LTI
V
D
R
---
E
V
S
----
L
E
E
T
P
G
A
L
K
D
I
L
Q
N
R
-
I
Q
G
R
V
I
V
K
L
----