@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U1N1: (2017-12-20 )
MSFLEGKKIVIMGVANKKSIAWGCAEAMLKQGAEIIYTYQNERMKKSLVKLVGEEAFTVECDVSSDESIEKAMNAIGEYAGEIHGLVHAVAYANKEELSGNVSDISRDGYQLAQDISSYSLIAVSKYAQPFLAPNSGIVSMTYLGSERAIPNYNMMGIAKASLEAAIRYLAAEFSPKGIRVNGISAGAIKTLAVTGVKDYQKLIQLSESRTPDQQGVTIEEVGNACAFLISPLSSGIIGDIIYVDKGVHLS
Atome Classification :
(65 SA)
...-......10......--.--.20........30.........40........50.----.----.---.....60..--......70........80.-.......90......-----.-.-100...-.....110.......120.......130-.-....----..140.......150.--......160.......170..--.....180.......190.......200.......210....---...220.......230........240.......250---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSF-LEG
K
K
I
V
I
M
G
VANK--K--
S
I
A
W
G
C
A
E
A
M
L
K-QG
A
E
I
I
Y
T
Y
Q
N
E
R
M
K
K
S
L
V
K
L
V----G----E---E
A
F
T
V
E
C
DV--SS
D
E
S
I
E
K
A
M
N
A
I
G
E
Y
A
G
E
-
I
H
G
L
V
H
A
V
A
YA
N
K
E
E
-----L-S-G
N
-
V
S
D
-ISRD
G
Y
Q
L
A
Q
D
I
SS
Y
S
L
I
A
V
S
K
YAQPFL-A-PNS
G
----
I
V
S
M
T
YLGSERAIPNY--N
M
M
G
I
A
K
A
S
L
E
A
A
I
R
Y
L
A
A
EF--SPK
G
I
R
V
NGISAG
A
I
K
T
L
A
VT
G
V
K
D
Y
Q
K
L
I
Q
L
SESRTPDQQG---V
T
I
E
E
V
G
N
A
C
A
F
L
I
S
-
P
L
SSGI
I
G
D
I
I
Y
VDKGVHLS----
31
PsiBlast_CBE
88.85
45%
0
- C- -
-
1QSG
3
FABI_ECOLI
B:
[5-257]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
30
PsiBlast_CBE
88.85
45%
0
- C- -
-
1QSG
3
FABI_ECOLI
C:
[5-257]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
29
PsiBlast_CBE
88.85
45%
0
- C- -
-
1QSG
3
FABI_ECOLI
D:
[5-257]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
28
PsiBlast_CBE
88.85
45%
0
- C- -
-
1QSG
3
FABI_ECOLI
E:
[5-257]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
27
PsiBlast_CBE
88.85
45%
0
- C- -
-
1QSG
1
FABI_ECOLI
F:
[5-257]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
26
PsiBlast_CBE
88.85
45%
0
- C- -
-
1QSG
1
FABI_ECOLI
G:
[5-257]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
25
PsiBlast_CBE
88.85
45%
0
- C- -
-
1QSG
7
FABI_ECOLI
H:
[5-257]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
8
PsiBlast_PDB
88.85
45%
0
- C- -
-
1QSG
3
FABI_ECOLI
A:
[5-257]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
134
HHSearch
87.46
45%
0
- C- -
-
1QSG
3
FABI_ECOLI
E:
[5-256]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
--
A
--
S
KL
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
QL--
G
---
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
G
D
Y
-
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
-----
53
PsiBlast_CBE
86.18
45%
-69
- C1 -
-
1QG6
2
FABI_ECOLI
C:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
52
PsiBlast_CBE
85.66
45%
-69
- C1 -
-
1QG6
2
FABI_ECOLI
D:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
22
PsiBlast_CBE
85.53
45%
-70
- C1 -
-
3PJD
2
FABI_ECOLI
B:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
A
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
65
PsiBlast_CBE
85.27
45%
-68
- C1 -
-
1D8A
2
FABI_ECOLI
A:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
55
PsiBlast_CBE
85.04
45%
-69
- C1 -
-
1QG6
2
FABI_ECOLI
A:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
45
PsiBlast_CBE
84.91
44%
-62
- C1 -
-
2QIO
2
?
C:
[1-254]
M
E
L
-
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
--
R
--
S
I
A
W
G
I
A
R
S
L
H
N
-
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
DTLE
G
----
Q
---
E
S
L
V
L
P
C
D
V
--
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
T
-
I
H
G
V
A
H
C
I
A
F
A
N
R
D
D
-----
L
-
K
-
G
E
-
F
V
D
-
T
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
-
T
-
E
G
G
N
----
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
--
G
Q
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
---
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
I
-----
54
PsiBlast_CBE
84.86
45%
-69
- C1 -
-
1QG6
2
FABI_ECOLI
B:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
44
PsiBlast_CBE
84.71
44%
-61
- C1 -
-
2QIO
2
?
D:
[1-254]
M
E
L
-
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
--
R
--
S
I
A
W
G
I
A
R
S
L
H
N
-
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
DTLE
G
----
Q
---
E
S
L
V
L
P
C
D
V
--
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
T
-
I
H
G
V
A
H
C
I
A
F
A
N
R
D
D
-----
L
-
K
-
G
E
-
F
V
D
-
T
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
-
T
-
E
G
G
N
----
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
--
G
Q
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
---
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
I
-----
36
PsiBlast_CBE
84.37
45%
-68
- C1 -
-
1I2Z
2
FABI_ECOLI
B:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
23
PsiBlast_CBE
84.21
45%
-69
- C1 -
-
3PJE
2
FABI_ECOLI
B:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
S
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
48
PsiBlast_CBE
84.17
44%
-55
- C1 -
-
3OJF
2
FABI_BACCR
D:
[2-254]
-
E
L
-
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
--
R
--
S
I
A
W
G
I
A
R
S
L
H
N
-
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
DTLE
G
----
Q
---
E
S
L
V
L
P
C
D
V
--
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
T
-
I
H
G
V
A
H
C
I
A
F
A
N
R
D
D
-----
L
-
K
-
G
E
-
F
V
D
-
T
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
-
T
-
E
G
G
N
----
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
--
G
Q
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
---
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
I
-----
10
PsiBlast_PDB
83.76
45%
-67
- C1 -
-
1I2Z
2
FABI_ECOLI
A:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
14
PsiBlast_PDB
83.65
45%
-68
- C1 -
-
1MFP
2
FABI_ECOLI
A:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
37
PsiBlast_CBE
83.48
45%
-64
- C1 -
-
1C14
2
FABI_ECOLI
B:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
3
PsiBlast_PDB
83.43
45%
-73
- C1 -
-
3PJD
2
FABI_ECOLI
A:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
A
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
21
PsiBlast_CBE
83.20
48%
-16
- C1 -
-
3OIF
2
FABI_BACSU
D:
[1-256]
M
N
F
S
L
E
G
R
N
I
V
V
M
G
V
A
N
K
--
R
--
S
I
A
W
G
I
A
R
S
L
H
E
-
A
G
A
R
L
I
F
T
Y
A
G
E
R
L
E
K
S
V
H
E
L
A
----
G
T
LDR
N
---
D
S
I
I
L
P
C
D
V
--
T
N
D
A
E
I
E
T
C
F
A
S
I
K
E
Q
V
G
V
-
I
H
G
I
A
H
C
I
A
F
A
N
K
E
E
-----
L
-
V
-
G
E
-
Y
L
N
-
T
N
R
D
G
F
L
L
A
H
N
I
S
S
Y
S
L
T
A
V
V
K
A
A
R
P
M
M
-
T
-
E
G
G
S
----
I
V
T
L
T
Y
L
G
G
E
L
V
M
P
N
Y
--
N
V
M
G
V
A
K
A
S
L
D
A
S
V
K
Y
L
A
A
D
L
--
G
K
E
N
I
R
V
N
S
I
S
A
G
P
I
R
T
L
S
A
K
G
-
S
D
F
N
S
I
L
K
D
I
E
E
R
A
P
L
R
R
T
---
T
T
P
E
E
V
G
D
T
A
A
F
L
F
S
-
D
M
S
R
G
I
T
G
E
N
L
H
V
D
S
G
F
H
I
T
----
9
PsiBlast_PDB
82.99
45%
-72
- C1 -
-
1C14
2
FABI_ECOLI
A:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
4
PsiBlast_PDB
82.96
45%
-74
- C1 -
-
3PJE
2
FABI_ECOLI
A:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
S
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
60
PsiBlast_CBE
82.90
45%
-66
- C1 -
-
1DFH
2
FABI_ECOLI
B:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
63
PsiBlast_CBE
82.88
45%
-64
- C1 -
-
1DFG
2
FABI_ECOLI
A:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
32
PsiBlast_CBE
82.88
45%
-69
- C1 -
-
1MFP
2
FABI_ECOLI
B:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
61
PsiBlast_CBE
82.66
45%
-62
- C1 -
-
1DFH
2
FABI_ECOLI
A:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
66
PsiBlast_CBE
82.51
49%
-52
- C1 -
-
4M89
2
?
B:
[2-251]
-
G
F
-
L
Q
G
K
K
I
L
I
T
G
M
I
S
E
--
R
--
S
I
A
Y
G
I
A
K
A
C
R
E
-
Q
G
A
E
L
A
F
T
Y
V
V
D
K
L
E
E
R
V
R
K
M
A
----
A
----
E
LD-
S
E
L
V
F
R
C
D
V
--
A
S
D
D
E
I
N
Q
V
F
A
D
L
G
K
H
W
D
G
-
L
D
G
L
V
H
S
I
G
F
A
P
K
E
A
-----
L
-
S
-
G
D
-
F
L
D
S
I
S
R
E
A
F
N
T
A
H
E
I
S
A
Y
S
L
P
A
L
A
K
A
A
R
P
M
M
R
G
-
R
N
S
A
----
I
V
A
L
S
Y
L
G
A
V
R
A
I
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
I
R
F
T
A
A
C
L
--
G
K
E
G
I
R
C
N
G
I
S
A
G
P
I
K
T
L
A
A
S
G
I
A
D
F
G
K
L
L
G
H
V
A
A
H
N
P
L
R
R
N
---
V
T
I
E
E
V
G
N
T
A
A
F
L
L
S
-
D
L
S
S
G
I
T
G
E
I
T
Y
V
D
G
G
--------
6
PsiBlast_PDB
82.05
45%
-63
- C1 -
-
4JQC
2
FABI_ECOLI
A:
[21-274]
M
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
2
PsiBlast_PDB
81.68
48%
-14
- C1 -
-
3OIG
2
FABI_BACSU
A:
[1-256]
M
N
F
S
L
E
G
R
N
I
V
V
M
G
V
A
N
K
--
R
--
S
I
A
W
G
I
A
R
S
L
H
E
-
A
G
A
R
L
I
F
T
Y
A
G
E
R
L
E
K
S
V
H
E
L
A
----
G
T
LDR
N
---
D
S
I
I
L
P
C
D
V
--
T
N
D
A
E
I
E
T
C
F
A
S
I
K
E
Q
V
G
V
-
I
H
G
I
A
H
C
I
A
F
A
N
K
E
E
-----
L
-
V
-
G
E
-
Y
L
N
-
T
N
R
D
G
F
L
L
A
H
N
I
S
S
Y
S
L
T
A
V
V
K
A
A
R
P
M
M
-
T
-
E
G
G
S
----
I
V
T
L
T
Y
L
G
G
E
L
V
M
P
N
Y
--
N
V
M
G
V
A
K
A
S
L
D
A
S
V
K
Y
L
A
A
D
L
--
G
K
E
N
I
R
V
N
S
I
S
A
G
P
I
R
T
L
S
A
K
G
I
S
D
F
N
S
I
L
K
D
I
E
E
R
A
P
L
R
R
T
---
T
T
P
E
E
V
G
D
T
A
A
F
L
F
S
-
D
M
S
R
G
I
T
G
E
N
L
H
V
D
S
G
F
H
I
T
----
64
PsiBlast_CBE
81.66
45%
-63
- C1 -
-
1D8A
2
FABI_ECOLI
B:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
135
HHSearch
81.15
47%
-53
- C1 -
-
4M89
2
?
B:
[2-255]
-
G
F
-
L
Q
G
K
K
I
L
I
T
G
M
I
S
E
--
R
--
S
I
A
Y
G
I
A
K
A
C
R
E
-
Q
G
A
E
L
A
F
T
Y
V
V
D
K
L
E
E
R
V
R
K
M
A
----
A
EL--
D
---
S
E
L
V
F
R
C
D
V
--
A
S
D
D
E
I
N
Q
V
F
A
D
L
G
K
H
W
D
G
-
L
D
G
L
V
H
S
I
G
F
A
P
K
E
A
-----
L
S
G
-
D
F
-
L
D
S
-
I
S
R
E
A
F
N
T
A
H
E
I
S
A
Y
S
L
P
A
L
A
K
A
A
R
P
M
M
-
R
G
R
N
S
A
----
I
V
A
L
S
Y
L
G
A
V
R
A
I
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
I
R
F
T
A
A
C
L
--
G
K
E
G
I
R
C
N
G
I
S
A
G
P
I
K
T
L
A
A
S
G
I
A
D
F
G
K
L
L
G
H
V
A
A
H
N
P
L
R
R
N
---
V
T
I
E
E
V
G
N
T
A
A
F
L
L
S
-
D
L
S
S
G
I
T
G
E
I
T
Y
V
D
G
G
Y
S
I
N
----
67
PsiBlast_CBE
80.88
49%
-50
- C1 -
-
4M89
2
?
A:
[2-251]
-
G
F
-
L
Q
G
K
K
I
L
I
T
G
M
I
S
E
--
R
--
S
I
A
Y
G
I
A
K
A
C
R
E
-
Q
G
A
E
L
A
F
T
Y
V
V
D
K
L
E
E
R
V
R
K
M
A
----
A
----
E
L
D-
S
E
L
V
F
R
C
D
V
--
A
S
D
D
E
I
N
Q
V
F
A
D
L
G
K
H
W
D
G
-
L
D
G
L
V
H
S
I
G
F
A
P
K
E
A
-----
L
-
S
-
G
D
-
F
L
D
S
I
S
R
E
A
F
N
T
A
H
E
I
S
A
Y
S
L
P
A
L
A
K
A
A
R
P
M
M
R
G
-
R
N
S
A
----
I
V
A
L
S
Y
L
G
A
V
R
A
I
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
I
R
F
T
A
A
C
L
--
G
K
E
G
I
R
C
N
G
I
S
A
G
P
I
K
T
L
A
A
S
G
I
A
D
F
G
K
L
L
G
H
V
A
A
H
N
P
L
R
R
N
---
V
T
I
E
E
V
G
N
T
A
A
F
L
L
S
-
D
L
S
S
G
I
T
G
E
I
T
Y
V
D
G
G
--------
62
PsiBlast_CBE
80.64
45%
-65
- C1 -
-
1DFG
2
FABI_ECOLI
B:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
24
PsiBlast_CBE
80.58
45%
-74
- C1 -
-
3PJF
2
FABI_ECOLI
B:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
V
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
7
PsiBlast_PDB
80.41
45%
-62
- C1 -
-
4JX8
2
FABI_ECOLI
A:
[21-274]
M
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
33
PsiBlast_CBE
80.24
45%
-67
- C1 -
-
1LXC
2
FABI_ECOLI
B:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
-------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
39
PsiBlast_CBE
79.79
45%
-61
- C1 -
-
5CG1
2
FABI_ECOLI
B:
[45-297]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
--------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
17
PsiBlast_PDB
79.65
45%
-65
- C1 -
-
5CG1
2
FABI_ECOLI
A:
[45-297]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
---------
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
34
PsiBlast_CBE
78.78
45%
-76
- C1 -
-
1LX6
2
FABI_ECOLI
B:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
-------------
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
12
PsiBlast_PDB
78.71
45%
-70
- C1 -
-
1LX6
2
FABI_ECOLI
A:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
-------------
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
5
PsiBlast_PDB
78.64
45%
-65
- C1 -
-
3PJF
2
FABI_ECOLI
A:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
V
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
----------
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
73
PsiBlast_CBE
78.51
42%
-62
- C1 -
-
5TRT
4
?
B:
[9-260]
M
G
F
-
L
D
G
K
R
I
L
L
T
G
L
L
S
N
--
R
--
S
I
A
Y
G
I
A
K
A
C
K
R
-
E
G
A
E
L
A
F
T
Y
V
G
D
R
F
K
D
R
I
T
E
F
A
----
A
----
E
F
G-
S
E
L
V
F
P
C
D
V
--
A
D
D
A
Q
I
D
A
L
F
A
S
L
K
T
H
W
D
S
-
L
D
G
L
V
H
S
I
G
F
A
P
R
E
A
-----
I
-
A
-
G
D
-
F
L
D
G
L
T
R
E
N
F
R
I
A
H
D
I
S
A
Y
S
F
P
A
L
A
K
A
A
L
P
M
L
-
S
-
D
D
A
S
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
T
M
G
L
A
K
A
A
L
E
A
S
V
R
Y
L
A
V
S
L
--
G
A
K
G
V
R
V
N
A
I
S
A
G
P
I
K
--------
S
F
G
K
I
L
D
F
V
E
S
N
S
P
L
K
R
N
---
V
T
I
E
Q
V
G
N
A
G
A
F
L
L
S
-
D
L
A
S
G
V
T
A
E
V
M
H
V
D
S
G
F
N
------
42
PsiBlast_CBE
78.45
45%
-69
- C1 -
-
4CV3
2
?
B:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
-----------------
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
40
PsiBlast_CBE
78.43
45%
-69
- C1 -
-
4D46
2
?
B:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
------
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
13
PsiBlast_PDB
77.72
45%
-65
- C1 -
-
1LXC
2
FABI_ECOLI
A:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
-------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
11
PsiBlast_PDB
77.67
45%
-61
- C1 -
-
1I30
2
FABI_ECOLI
A:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
--------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
35
PsiBlast_CBE
77.50
45%
-64
- C1 -
-
1I30
2
FABI_ECOLI
B:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
--------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
127
HHSearch
77.42
48%
-9
- C1 -
-
3OIG
2
FABI_BACSU
A:
[3-255]
-
F
S
-
L
E
G
R
N
I
V
V
M
G
V
--
A
NK
R
--
S
I
A
W
G
I
A
R
S
L
H
E
-
A
G
A
R
L
I
F
T
Y
A
G
E
R
L
E
K
S
V
H
E
L
A
----
G
T
LDR
N
---
D
S
I
I
L
P
C
D
V
--
T
N
D
A
E
I
E
T
C
F
A
S
I
K
E
Q
V
G
V
-
I
H
G
I
A
H
C
I
A
F
A
N
K
E
E
-----
L
-
V
-
G
E
-
Y
L
N
-
T
N
R
D
G
F
L
L
A
H
N
I
S
S
Y
S
L
T
A
V
V
K
A
A
R
P
M
M
-
T
-
E
G
G
S
----
I
V
T
L
T
Y
L
G
G
E
L
V
M
P
N
Y
--
N
V
M
G
V
A
K
A
S
L
D
A
S
V
K
Y
L
A
A
D
L
--
G
K
E
N
I
R
V
N
S
I
S
A
G
P
I
R
T
L
S
A
K
G
I
S
D
F
N
S
I
L
K
D
I
E
E
R
A
P
L
R
R
T
---
T
T
P
E
E
V
G
D
T
A
A
F
L
F
S
-
D
M
S
R
G
I
T
G
E
N
L
H
V
D
S
G
F
H
I
-----
56
PsiBlast_CBE
77.11
45%
-68
- C1 -
-
1DFI
1
FABI_ECOLI
D:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
----------
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
20
PsiBlast_PDB
77.08
45%
-67
- C1 -
-
4CV3
2
?
A:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
-----------------
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
43
PsiBlast_CBE
76.85
45%
-63
- C1 -
-
4CV2
2
?
B:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
------------------
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
59
PsiBlast_CBE
76.67
45%
-70
- C1 -
-
1DFI
1
FABI_ECOLI
A:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
----------
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
38
PsiBlast_CBE
76.43
45%
-66
- C1 -
-
5CG2
2
FABI_ECOLI
B:
[45-297]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
-----------------
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
57
PsiBlast_CBE
76.42
45%
-67
- C1 -
-
1DFI
1
FABI_ECOLI
C:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
----------
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
58
PsiBlast_CBE
76.32
45%
-70
- C1 -
-
1DFI
1
FABI_ECOLI
B:
[2-253]
--
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
LG-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
----------
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
1
PsiBlast_PDB
76.31
48%
-11
- C1 -
-
3OIF
2
FABI_BACSU
A:
[1-256]
M
N
F
S
L
E
G
R
N
I
V
V
M
G
V
A
N
K
--
R
--
S
I
A
W
G
I
A
R
S
L
H
E
-
A
G
A
R
L
I
F
T
Y
A
G
E
R
L
E
K
S
V
H
E
L
A
----
G
T
LDR
N
---
D
S
I
I
L
P
C
D
V
--
T
N
D
A
E
I
E
T
C
F
A
S
I
K
E
Q
V
G
V
-
I
H
G
I
A
H
C
I
A
F
A
N
K
E
E
-----
L
-
V
-
G
E
-
Y
L
N
-
T
N
R
D
G
F
L
L
A
H
N
I
S
S
Y
S
L
T
A
V
V
K
A
A
R
P
M
M
-
T
-
E
G
G
S
----
I
V
T
L
T
Y
L
G
G
E
L
V
M
P
N
Y
--
N
V
M
G
V
A
K
A
S
L
D
A
S
V
K
Y
L
A
A
D
L
--
G
K
E
N
I
R
V
N
S
I
S
A
G
P
I
R
T
L
S
A
K
G
I
S
D
F
N
S
I
L
K
D
I
E
E
R
A
P
L
R
R
T
---
T
T
P
E
E
V
G
D
T
A
A
F
L
F
S
-
D
M
S
R
G
I
T
G
E
N
L
H
V
D
S
G
F
H
I
T
----
41
PsiBlast_CBE
75.87
45%
-62
- C1 -
-
4D46
2
?
A:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
------------------
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
18
PsiBlast_PDB
75.41
45%
-65
- C1 -
-
5CG2
2
FABI_ECOLI
A:
[45-297]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
-----------------
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
19
PsiBlast_PDB
73.65
45%
-68
- C1 -
-
4CV2
2
?
A:
[2-254]
-
G
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
G-
S
D
I
V
L
Q
C
D
V
--
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
-----
L
-
D
-
G
D
Y
V
N
A
-
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
-
N
-
P
G
S
A
----
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
--
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
-------------------
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
----
136
Fugue
67.65
43%
-40
- C1 -
-
1DFI
1
FABI_ECOLI
A:
[1-257]
G
-
F
-
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
I
A
Y
G
I
A
Q
A
M
H
R
E
-
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
----
A
----
Q
L
GS
D
-
I
V
L
Q
C
D
V
AE--
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
-K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
LDGDY
V
-
N
-
A
V
-
T
-----
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
------
L
N
PG
S
A
L
L
T
L
S
Y
L
G
A
E
R
-
A
I
P
N
YN-
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
-
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
---------
M
L
A
H
C
E
A
-
V
T
P
I
--
R
R
T
V
-
T
I
E
D
V
G
N
S
A
A
F
L
C
S
D-
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
AMNE