@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0003: (2016-03-11 )
MMKDMTTGNPTKLIFLFAMPMLIGNLFQQFYTMIDAVIVGKFVSVDALAAVGATNSVNFFMISLIIGLMSGISVVVAQYFGFKDYDRLKDVIATATYAVVFSAIILTVAGVLLAKPLLILLRTPANILDDSTIFLTTLFIGILPMSLYNGMAAILRALGNSITPLIFLILSSLMNIALDFLFVVYMDMGVRGAAIATVLSQTAAAIAVIYYAYRHVPFMRIERAKFKLSTPLLKEMVRIGLPSGLQGSFISIGNMALQSLINGFGSSVVAAYTAASRIDSLTYQPGIAFGAASSMFAGQNIGAGKIDRVREGFWSGIKVVTAISIGITILVQLFARQFLLLFVDSSETEVINIGVSYLLIVSLFYVVVGILFVVRETLRGTGDAMVPLAMGIFELVSRLVIGFVLSLYIGYVGLWWATPVAWITATILGVWRYKSGAWQKKAVIRRK
Atome Classification :
(20 SA)
---.........10........20........30........40........50........60........70........80........-90........100.......110.......120.---......--130.-......140-....--...150.......160.-......170---.......180...----.....190.......200-.......210-..-.....--.220.......230--........240.....-..250.......260...-....-.270.......280.......290.......300.......310.......320.....--..330.......340.......350...-.....360.......370.......380.......390..-.-...-.400...-...--.-------.410.......420.......-430........440.....---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MMKDMTTGNP
T
K
L
I
F
L
F
A
M
P
M
L
I
G
N
L
F
Q
Q
F
Y
T
M
I
D
A
V
I
V
G
K
F
V
S
V
D
A
L
AAVGATNS
V
N
F
F
M
I
S
L
I
I
G
L
MS
G
I
S
V
V
V
A
Q
Y
FGFK
D
Y
D
R
L
K
-
D
V
I
A
T
A
T
Y
A
V
V
F
S
A
I
I
L
T
V
A
G
V
L
L
A
K
P
L
L
I
L
L
RT---
P
A
NILD--D
S
T
I
-
F
L
T
T
L
F
I
G
I
-
L
P
M
S
--
L
Y
N
G
M
A
A
I
L
R
A
LGNS
I
T
-
P
L
I
F
L
I
L
S
S
---
L
M
N
I
A
L
D
F
L
-
F
V
V
----
Y
M
DMGV
R
G
A
A
I
A
T
V
L
S
Q
T
-
A
A
A
I
A
V
I
Y
Y
--
A
Y
-RHV
P
F
--
M
R
I
E
R
A
KFKLS
T
P
---
L
L
K
E
M
V
R
IGLPSGLQG-
S
F
I
S
I
G
N
M
A
L
Q
S
L
-
I
N
G
F-
G
S
S
V
-
V
A
A
Y
T
A
A
S
RIDSLTYQPGIAFGA
A
S
S
MFAGQNIGA
G
K
I
D
R
V
R
E
G
F
WSG
I
K
V
V
T
A
I
S
I
G
I
--
T
I
L
V
Q
L
F
A
R
Q
F
L
L
L
F
VDSSE
T
E
V
I
-
N
I
G
-
V
S
Y
L
L
I
V
S
L
F
Y
V
V
V
G
I
L
F
V
V
R
E
T
LRGTGD
A
M
V
P
L
A
M
G
I
F
E
-
L
-
V
S
R
-
L
V
-
I
G
F
V
-
L
S
L
--
Y
-------
I
G
Y
V
G
L
W
WA
T
P
V
A
W
I
T
A
T
I
L
G
-
V
W
-RYKSGAW
Q
K
KAVIRRK---
7
PsiBlast_PDB
96.29
26%
-129
- C2 -
4MLB
22
?
A:
[21-462]
----------
G
D
P
K
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
-
N
V
---
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
MGA
K
G
E
A
V
E
--
L
A
I
E
-
Y
A
R
V
L
L
A
G
A
-
F
I
I
V
--
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
-
A
M
L
A
M
V
L
G
S
---
G
L
N
I
V
L
D
P
I
-
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
-
V
T
S
L
F
I
A
Y
W
--
L
F
V
K
R
D
T
Y
--
V
D
I
T
L
R
D
F
S
P
S
R
E
---
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
-
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
T
A
G
-
G
E
N
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
T
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
--
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
S
E
S
A
Q
V
I
-
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
-
V
M
Q
-
V
G
-
F
A
Y
I
-
F
V
H
--
Y
TT-----
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
T
S
--------
6
PsiBlast_PDB
95.99
26%
-130
- C2 -
3WBN
6
?
A:
[14-454]
----------
G
D
P
K
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
-
N
V
---
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
MGA
K
G
E
A
V
E
--
L
A
I
E
-
Y
A
R
V
L
L
A
G
A
-
F
I
I
V
--
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
-
A
M
L
A
M
V
L
G
S
---
G
L
N
I
V
L
D
P
I
-
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
-
V
T
S
L
F
I
A
Y
W
--
L
F
V
K
R
D
T
Y
--
V
D
I
T
L
R
D
F
S
P
S
R
E
---
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
-
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
T
A
G
-
G
E
N
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
--
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
S
E
S
A
Q
V
I
-
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
-
V
M
Q
-
V
G
-
F
A
Y
I
-
F
V
H
--
Y
T
T-----
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
T
---------
8
PsiBlast_PDB
95.65
26%
-134
- C2 -
3W4T
9
?
A:
[14-454]
----------
G
D
P
K
K
A
I
V
R
L
S
I
A
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
-
N
V
---
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
GA
K
G
E
A
V
E
--
L
A
I
E
-
Y
A
R
V
L
L
A
G
A
-
F
I
I
V
--
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
-
A
M
L
A
M
V
L
G
S
---
G
L
N
I
V
L
D
P
I
-
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
-
V
T
S
L
F
I
A
Y
W
--
L
F
V
K
R
D
T
Y
--
V
D
I
T
L
R
D
F
S
P
S
R
E
---
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
-
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
T
A
G
-
G
E
N
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
--
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
-----
V
I
-
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
-
V
M
Q
-
V
G
-
F
A
Y
I
-
F
V
H
--
Y
T
T-----
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
T
---------
2
PsiBlast_PDB
94.93
26%
-131
- C2 -
3VVO
10
?
A:
[14-455]
----------
G
D
P
K
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
-
N
V
---
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
GA
K
G
E
A
V
E
--
L
A
I
E
-
Y
A
R
V
L
L
A
G
A
-
F
I
I
V
--
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
-
A
M
L
A
M
V
L
G
S
---
G
L
N
I
V
L
D
P
I
-
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
-
V
T
S
L
F
I
A
Y
W
--
L
F
V
K
R
D
T
Y
--
V
D
I
T
L
R
D
F
S
P
S
R
E
---
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
-
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
T
A
G
-
G
E
N
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
--
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
------
I
-
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
-
V
M
Q
-
V
G
-
F
A
Y
I
-
F
V
H
--
Y
TT-----
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
T
S
--------
5
PsiBlast_PDB
94.85
26%
-131
- C2 -
3VVS
13
?
A:
[14-454]
----------
G
D
P
K
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
-
N
V
---
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
GA
K
G
E
A
V
E
--
L
A
I
E
-
Y
A
R
V
L
L
A
G
A
-
F
I
I
V
--
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
-
A
M
L
A
M
V
L
G
S
---
G
L
N
I
V
L
D
P
I
-
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
-
V
T
S
L
F
I
A
Y
W
--
L
F
V
K
R
D
T
Y
--
V
D
I
T
L
R
D
F
S
P
S
R
E
---
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
-
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
T
A
G
-
G
E
N
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
--
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
-------
I
-
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
-
V
M
Q
-
V
G
-
F
A
Y
I
-
F
V
H
--
Y
TT-----
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
T
---------
4
PsiBlast_PDB
93.15
26%
-132
- C2 -
3VVR
4
?
A:
[14-454]
----------
G
D
P
K
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
-
N
V
---
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
GA
K
G
E
A
V
E
--
L
A
I
E
-
Y
A
R
V
L
L
A
G
A
-
F
I
I
V
--
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
-
A
M
L
A
M
V
L
G
S
---
G
L
N
I
V
L
D
P
I
-
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
-
V
T
S
L
F
I
A
Y
W
--
L
F
V
K
R
D
T
Y
--
V
D
I
T
L
R
D
F
S
P
S
R
E
---
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
-
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
T
A
G
--
E
N
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
--
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
------
I
-
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
-
V
M
Q
-
V
G
-
F
A
Y
I
-
F
V
H
-----------
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
T
---------
1
PsiBlast_PDB
90.94
26%
-131
- C2 -
3VVN
12
?
A:
[14-454]
----------
G
D
P
K
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
-
N
V
---
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
GA--
E
A
V
E
--
L
A
I
E
-
Y
A
R
V
L
L
A
G
A
-
F
I
I
V
--
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
-
A
M
L
A
M
V
L
G
S
---
G
L
N
I
V
L
D
P
I
-
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
-
V
T
S
L
F
I
A
Y
W
--
L
F
V
K
R
D
T
Y
--
V
D
I
T
L
R
D
F
S
P
S
R
E
---
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
-
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
T
A
G
-
G
E
N
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
--
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
----
A
Q
V
I
-
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
-
V
M
Q
-
V
G
-
F
A
Y
I
-
F
V
H
--
Y
TT-----
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
T
---------
17
HHSearch
90.86
25%
-132
- C2 -
3W4T
9
?
A:
[9-444]
-----
V
Q
L
L
R
G
D
P
K
K
A
I
V
R
L
S
I
A
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
-
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
M
G
A
---
K
G
E
A
V
E
--
L
A
I
E
-
Y
A
R
V
L
L
A
G
A
-
F
I
I
V
--
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
-
A
M
L
A
M
V
L
G
S
---
G
L
N
I
V
L
D
P
I
-
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
-
V
T
S
L
F
I
A
Y
W
--
L
F
V
K
R
D
T
Y
--
V
D
I
T
L
R
D
F
S
P
S
R
E
---
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
-
L
S
M
S
I
A
M
F
F
L
N
S
V
-
A
I
T
A
G
G
E
N
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
--
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
-----
V
I
K
G
D
L
-
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
-
T
L
V
M
Q
-
V
G
-
F
A
Y
I
-
F
V
H
Y
T
T
-------
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
-
F
L
-
W
G
-----------------
3
PsiBlast_PDB
86.50
26%
-128
- C2 -
3VVP
1
?
A:
[14-453]
----------
G
D
P
K
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
-
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
-
N
V
---
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
-------
A
V
E
--
L
A
I
E
-
Y
A
R
V
L
L
A
G
A
-
F
I
I
V
--
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
-
A
M
L
A
M
V
L
G
S
---
G
L
N
I
V
L
D
P
I
-
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
-
V
T
S
L
F
I
A
Y
W
--
L
F
V
K
R
D
T
Y
--
V
D
I
---
D
F
S
P
S
R
E
---
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
-
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
T
A
G
-
G
E
N
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
--
V
A
F
I
M
L
---------------------
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
-
V
M
Q
-
V
G
-
F
A
Y
I
-
F
V
H
--
Y
TT-----
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
----------
22
Fugue
85.79
25%
-123
* C2 *
4LZ6
-
?
A:
[1-446]
QKQ
Q
S
E
R
L
G
T
E
A
I
P
K
L
L
R
S
L
S
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
D
T
I
F
I
S
Y
A
V
G
I
E
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
-
Q
V
F
G
N
I
L
T
V
I
L
V
L
S
V
I
G
F
I
S
A
F
T
L
L
G
P
A
L
Q
L
F
G
A
---
T
S
V
T
Q
G
--
Y
A
T
D
-
Y
L
F
P
I
L
L
G
S
-
I
F
F
F
--
F
A
F
A
A
N
N
I
I
R
S
E
G
N
A
T
F
-
A
M
V
T
M
I
V
P
A
---
V
L
N
I
L
L
D
V
L
-
F
I
F
----
G
L
N
M
G
V
L
G
A
S
I
A
T
V
I
A
Q
A
-
S
V
T
G
L
V
L
R
Y
--
F
L
-
T
G
K
S
T
--
L
S
L
H
W
S
D
L
R
M
K
G
S
---
V
I
K
E
V
C
L
V
G
L
P
A
F
V
Q
Q
-
S
S
A
S
L
M
M
I
A
I
N
S
M
-
L
L
R
F
-
G
S
D
F
Y
V
G
V
F
G
L
V
Q
R
I
M
M
F
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
I
V
G
Y
N
Y
G
A
K
Q
Y
S
R
L
R
E
T
V
M
L
G
F
K
V
A
T
I
F
S
I
G
I
--
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
--
T
A
D
R
E
V
I
-
Q
A
G
-
V
S
A
M
H
I
L
F
C
V
T
F
L
I
G
A
Q
I
V
A
G
G
L
Y
Q
S
L
G
K
P
K
Q
A
L
I
L
S
L
S
R
Q
I
-
I
F
L
-
I
P
-
L
V
L
I
-
L
P
H
--
I
-------
F
G
L
S
G
V
W
W
A
F
P
I
A
D
V
L
S
F
I
L
T
-
V
V
-
L
L
Y
----
R
D
R
N
V
F
F
L
K
---
9
PsiBlast_PDB
82.31
25%
-130
- C2 -
4LZ6
-
?
A:
[15-433]
--------------
K
L
L
R
S
L
S
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
D
T
I
F
I
S
Y
A
V
G
I
E
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
-
Q
V
F
G
N
I
L
T
V
I
L
V
L
S
V
I
G
F
I
S
A
F
T
L
L
G
P
A
L
Q
L
F
G
A
---
T
S
V
T
Q
G
--
Y
A
T
D
-
Y
L
F
P
I
L
L
G
S
-
I
F
F
F
--
F
A
F
A
A
N
N
I
I
R
S
E
G
N
A
T
F
-
A
M
V
T
M
I
V
P
A
---
V
L
N
I
L
L
D
V
L
-
F
I
F
----
G
L
N
M
G
V
L
G
A
S
I
A
T
V
I
A
Q
A
-
S
V
T
G
L
V
L
R
Y
--
F
L
-
T
G
K
S
T
--
L
S
L
H
W
S
D
L
R
M
K
G
S
---
V
I
K
E
V
C
L
V
G
L
P
A
F
V
Q
Q
-
S
S
A
S
L
M
M
I
A
I
N
S
M
-
L
L
R
F
-
G
S
D
F
Y
V
G
V
F
G
L
V
Q
R
I
M
M
F
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
I
V
G
Y
N
Y
G
A
K
Q
Y
S
R
L
R
E
T
V
M
L
G
F
K
V
A
T
I
F
S
I
G
I
--
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
--
T
A
D
R
E
V
I
-
Q
A
G
-
V
S
A
M
H
I
L
F
C
V
T
F
L
I
G
A
Q
I
V
A
G
G
L
Y
Q
S
L
G
K
P
K
Q
A
L
I
L
S
L
S
R
-
Q
-
I
I
F
-
L
I
P
L
V
L
I
-
L
P
H
--
I
-------
F
G
L
S
G
V
W
W
A
F
P
I
A
D
V
L
S
F
I
L
T
-
V
---------------------
23
Fugue
81.36
18%
-115
- C2 -
3MKT
-
?
A:
[2-461]
---
E
N
S
V
H
R
Y
K
K
E
A
S
N
L
I
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
I
M
A
G
G
V
S
A
I
D
-
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
-
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
I
A
V
L
F
Q
T
Q
-
F
I
I
R
F
M
D
V
---
E
E
A
M
A
T
--
K
T
V
G
-
Y
M
H
A
V
I
F
A
V
-
P
A
Y
L
--
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
T
K
P
-
A
M
V
I
G
F
I
G
L
---
L
L
N
I
P
L
N
W
I
-
F
V
Y
GKFG
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
-
I
M
L
L
L
L
L
F
Y
--
I
V
-
T
S
K
R
L
AH
V
K
V
F
E
T
F
H
K
P
Q
P
K
---
E
L
I
R
L
F
R
L
G
F
P
V
A
A
A
L
-
F
F
E
V
T
L
F
A
V
V
A
L
L
-
V
A
P
L
-
G
S
T
V
-
V
A
A
H
Q
V
A
L
N
F
S
S
L
V
F
M
F
P
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
--
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
--
T
E
N
Q
V
V
V
-
A
L
A
-
M
Q
L
L
L
F
A
A
I
Y
Q
C
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
Y
K
D
M
T
A
I
F
H
R
T
F
I
S
-
Y
-
W
V
L
G
L
P
-
T
G
Y
I
-
L
G
M
--
T
NWLTEQP
L
G
A
K
G
F
W
L
G
F
I
I
G
L
S
A
A
A
L
M
L
-
G
Q
-
R
L
Y
W
L
Q
K
Q
S
D
D
V
Q
L
H
L
A
A
K
10
PsiBlast_PDB
79.92
25%
-145
- C- -
4LZ9
1
?
A:
[15-433]
--------------
K
L
L
R
S
L
S
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
D
T
I
F
I
S
Y
A
V
G
I
E
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
-
Q
V
F
G
N
I
L
T
V
I
L
V
L
S
V
I
G
F
I
S
A
F
T
L
L
G
P
A
L
Q
L
F
G
A
---
T
S
V
T
Q
G
--
Y
A
T
D
-
Y
L
F
P
I
L
L
G
S
-
I
F
F
F
--
F
A
F
A
A
N
N
I
I
R
S
E
G
N
A
T
F
-
A
M
V
T
M
I
V
P
A
---
V
L
N
I
L
L
D
V
L
-
F
I
F
----
G
L
N
M
G
V
L
G
A
S
I
A
T
V
I
A
Q
A
-
S
V
T
G
L
V
L
R
Y
--
F
L
-
T
G
K
S
T
--
L
S
L
H
W
S
D
L
R
M
K
G
S
---
V
I
K
E
V
C
L
V
G
L
P
A
F
V
Q
Q
-
S
S
A
S
L
M
M
I
A
I
N
S
M
-
L
L
R
F
-
G
S
D
F
Y
V
G
V
F
G
L
V
Q
R
I
M
M
F
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
I
V
G
Y
N
Y
G
A
K
Q
Y
S
R
L
R
E
T
V
M
L
G
F
K
V
A
T
I
F
S
I
G
I
--
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
--
T
A
D
R
E
V
I
-
Q
A
G
-
V
S
A
M
H
I
L
F
C
V
T
F
L
I
G
A
Q
I
V
A
G
G
L
Y
Q
S
L
G
K
P
K
Q
A
L
I
L
S
L
S
R
-
Q
-
I
I
F
-
L
I
P
L
V
L
I
-
L
P
H
--
I
-------
F
G
L
S
G
V
W
W
A
F
P
I
A
D
V
L
S
F
I
L
T
-
V
---------------------
14
PsiBlast_PDB
73.25
22%
-110
- C2 -
4HUL
1
?
A:
[14-393]
--------------
R
L
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
A
G
K
E
D
-
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
---
A
G
K
T
G
-
E
A
G
E
T
G
R
Q
G
I
W
F
-
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
P
F
R
N
---
W
L
T
L
S
D
Y
V
E
G
T
M
-
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
--
M
V
H
---
R
A
L
H
A
Y
A
S
S
L
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
-
F
V
Y
GKFG
M
P
A
L
G
G
A
G
C
G
V
A
T
M
A
V
F
W
-
F
S
A
L
A
L
W
I
Y
--
I
A
-
K
E
-
K
F
--
F
R
P
F
G
L
T
A
K
F
G
K
P
DWA
V
F
K
Q
I
W
K
I
G
A
P
I
G
L
S
Y
-
F
L
E
A
S
A
F
S
F
I
V
F
L
-
I
A
P
F
-
G
E
D
Y
-
V
A
A
Q
Q
V
G
I
S
L
S
G
I
L
Y
M
I
P
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
--
Y
I
S
G
V
S
L
V
S
G
W
V
L
A
V
--
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
A
V
L
-
S
I
A
-
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
------------------------------------------------------------------------------
16
PsiBlast_PDB
72.76
22%
-111
- C2 -
4HUN
1
?
A:
[14-393]
--------------
R
L
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
A
G
K
E
D
-
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
---
A
G
K
T
G
-
E
A
G
E
T
G
R
Q
G
I
W
F
-
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
P
F
R
N
---
W
L
T
L
S
D
YV
E
G
T
M
-
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
--
M
V
H
---
R
A
L
H
A
Y
A
S
S
L
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
-
F
V
Y
GKFG
M
P
A
L
G
G
A
G
C
G
V
A
T
M
A
V
F
W
-
F
S
A
L
A
L
W
I
Y
--
I
A
-
K
E
-
K
F
--
F
R
P
F
G
L
T
A
K
F
G
K
P
DWA
V
F
K
Q
I
W
K
I
G
A
P
I
G
L
S
Y
-
F
L
E
A
S
A
F
S
F
I
V
F
L
-
I
A
P
F
-
G
E
D
Y
-
V
A
A
Q
Q
V
G
I
S
L
S
G
I
L
Y
M
I
P
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
--
Y
I
S
G
V
S
L
V
S
G
W
V
L
A
V
--
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
A
V
L
-
S
I
A
-
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
------------------------------------------------------------------------------
15
PsiBlast_PDB
72.19
22%
-113
- C2 -
4HUM
1
?
A:
[14-393]
--------------
R
L
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
A
G
K
E
D
-
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
---
A
G
K
T
G
-
E
A
G
E
T
G
R
Q
G
I
W
F
-
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
P
F
R
N
---
W
L
T
L
S
D
YV
E
G
T
M
-
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
--
M
V
H
---
R
A
L
H
A
Y
A
S
S
L
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
-
F
V
Y
GKFG
M
P
A
L
G
G
A
G
C
G
V
A
T
M
A
V
F
W
-
F
S
A
L
A
L
W
I
Y
--
I
A
-
K
E
-
K
F
--
F
R
P
F
G
L
T
A
K
F
G
K
P
DWA
V
F
K
Q
I
W
K
I
G
A
P
I
G
L
S
Y
-
F
L
E
A
S
A
F
S
F
I
V
F
L
-
I
A
P
F
-
G
E
D
Y
-
V
A
A
Q
Q
V
G
I
S
L
S
G
I
L
Y
M
I
P
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
--
Y
I
S
G
V
S
L
V
S
G
W
V
L
A
V
--
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
A
V
L
-
S
I
A
-
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
------------------------------------------------------------------------------
13
PsiBlast_PDB
70.65
22%
-109
- C2 -
4HUK
1
?
A:
[14-393]
--------------
R
L
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
A
G
K
E
D
-
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
---
A
G
K
T
G
-
E
A
G
E
T
G
R
Q
G
I
W
F
-
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
P
F
R
N
---
W
L
T
L
S
D
YV
E
G
T
M
-
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
--
M
V
H
---
R
A
L
H
A
Y
A
S
S
L
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
-
F
V
Y
G
K
FG
M
P
A
L
G
G
A
G
C
G
V
A
T
M
A
V
F
W
-
F
S
A
L
A
L
W
I
Y
--
I
A
-
K
E
-
K
F
--
F
R
P
F
G
L
T
A
K
F
G
K
P
DWA
V
F
K
Q
I
W
K
I
G
A
P
I
G
L
S
Y
-
F
L
E
A
S
A
F
S
F
I
V
F
L
-
I
A
P
F
-
G
E
D
Y
-
V
A
A
Q
Q
V
G
I
S
L
S
G
I
L
Y
M
I
P
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
--
Y
I
S
G
V
S
L
V
S
G
W
V
L
A
V
--
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
A
V
L
-
S
I
A
-
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
------------------------------------------------------------------------------
25
Fugue
70.14
16%
-128
- C2 -
4D10
-
CSN2_HUMAN
B:
[34-447]
-----
V
D
L
E
N
Q
Y
Y
N
S
K
A
L
K
E
D
D
P
K
A
A
L
S
S
F
Q
K
V
L
E
L
E
G
E
K
G
E
W
G
F
K
A
L
K
Q
M
I
K
I
N
F
K
L
T
N
F
P
E
M
M
N
R
Y
K
Q
L
L
T
Y
I
R
S
A
V
T
R
N
Y
S
E
K
S
I
N
S
I
L
-
D
Y
I
S
T
S
K
Q
M
D
L
L
Q
E
F
Y
E
T
T
L
E
A
L
---------
K
D
---
A
K
N
-----
D
R
L
W
-
F
K
T
N
T
K
L
G
K
-
L
Y
L
E
R
E
E
Y
G
K
L
Q
K
I
L
R
Q
L
H
Q
S
C
Q
-
T
Q
L
L
E
I
Y
A
L
---
E
I
Q
M
Y
T
A
Q
K
N
N
K
K
----
L
K
A
L
Y
E
Q
S
L
H
I
K
S
A
I
P
H
P
L
I
M
G
V
I
R
E
C
G
--
G
K
-
M
H
L
R
E
--
G
E
F
E
K
A
H
T
D
F
-
F
E
---
A
F
K
N
Y
D
E
S
G
S
P
R
R
T
T
C
L
K
Y
L
V
L
A
N
M
L
M
K
S
G
-
I
N
P
F
-
D
S
Q
E
-
A
K
P
Y
K
N
D
P
E
I
--------
L
A
M
T
N
L
V
S
A
Y
Q
N
N
D
--
I
T
E
F
E
K
I
L
K
T
N
H
S
N
I
M
D
D
P
F
I
R
E
H
I
--
E
E
L
L
R
N
I
R
T
Q
V
L
I
K
L
I
K
P
---------------------
Y
T
R
I
H
I
P
F
I
S
K
E
L
N
I
D
V
A
D
V
E
S
L
L
V
Q
C
I
L
D
-
N
-
T
I
H
-
G
R
-
I
D
Q
V
N
Q
L
L
--
E
-------
L
D
H
------
Q
K
R
G
G
A
R
Y
T
A
L
D
-
K
W
-
T
N
Q
L
N
S
L
N
Q
A
V
V
S
K
L
A
---
12
PsiBlast_PDB
69.06
20%
-112
- C2 -
3MKU
1
?
A:
[18-385]
--------------------
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
I
M
A
G
G
V
S
A
I
D
-
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
I
---
A
V
L
F
Q
T
Q
F
I
I
R
F
M
D
---
V
E
E
A
M
A
--
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
-
P
A
Y
L
--
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
T
K
P
-
A
M
V
I
G
F
I
G
L
---
L
L
N
I
P
L
N
W
I
-
F
V
Y
GKFG
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
-
I
M
L
L
L
L
L
F
Y
IV
T
S
-
K
R
L
A
H
--
V
K
V
F
E
T
F
H
K
P
Q
P
K
---
E
L
I
R
L
F
R
L
G
F
P
V
A
-
A
A
-
L
F
F
E
V
T
L
F
A
V
V
A
L
L
V
A
P
L
-
G
S
T
V
-
V
A
A
H
Q
V
A
L
N
F
S
S
L
V
F
M
F
P
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
--
G
E
Q
D
T
K
G
A
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
--
V
V
V
-
A
L
A
-
M
Q
L
L
L
F
A
A
I
Y
Q
C
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
Y
K
D
-----------------------------------------------------------------------------------
11
PsiBlast_PDB
68.78
20%
-109
- C2 -
3MKT
-
?
A:
[19-386]
--------------------
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
I
M
A
G
G
V
S
A
I
D
-
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
I
---
A
V
L
F
Q
T
Q
F
I
I
R
F
M
D
---
V
E
E
A
M
A
--
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
-
P
A
Y
L
--
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
T
K
P
-
A
M
V
I
G
F
I
G
L
---
L
L
N
I
P
L
N
W
I
-
F
V
Y
GKFG
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
-
I
M
L
L
L
L
L
F
Y
IV
T
S
-
K
R
L
A
H
--
V
K
V
F
E
T
F
H
K
P
Q
P
K
---
E
L
I
R
L
F
R
L
G
F
P
V
A
-
A
A
-
L
F
F
E
V
T
L
F
A
V
V
A
L
L
V
A
P
L
-
G
S
T
V
-
V
A
A
H
Q
V
A
L
N
F
S
S
L
V
F
M
F
P
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
--
G
E
Q
D
T
K
G
A
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
--
V
V
V
-
A
L
A
-
M
Q
L
L
L
F
A
A
I
Y
Q
C
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
Y
K
D
-----------------------------------------------------------------------------------