@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0223: (2016-03-13 )
MTIANSITDLIGKTPIVKLNRLPEAGSADVYVKLEFQNPGGSVKDRIANAMIESAEKSGALKPGDTIIEPTSGNTGIGLAMVAAAKGYQAIFVMPETMSLERRKLLQAYGAKLVLTPGPDGMKGAIAKAEELAKENNYFVPQQFHNPANPAVHEETTGPEIVEAFGKDGLDAFIAGVGTGGTVTGVGHVLKKNYPDVKIYALEPEESPVLSGGSPSPHKIQGIGAGFVPDTLDTKVYDGILKVSSEDALETAREVAKKEGILVGISSGATIKAALDLAKELGAGKKVLAIVASNGERYLSTPLYNFED
Atome Classification :
(71 SA)
------------------------------------.........10........20.-.--.----..-------..--.30........40........50........60..--.-.-..-.-.70........80........90........100.......110.....---..---120...---....130...-.--.--.-..140.......150.-......160......---.-170........180.......190-...-.....200...-----....-----210.------.-----.....220.......230.......240.......250.......260.......270......-.--280---..-......290-.......300..-....----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------MT
I
A
N
S
I
T
D
L
IGKT
P
I
V
K
LNRL-P--E----AG-------SA--
D
V
Y
V
K
L
E
F
QNPGG
S
V
K
D
R
I
A
N
A
M
I
E
S
A
EKSGALKP--G-D-
T
I
-
I
-EPTSGNT
G
I
G
L
A
M
V
A
AAKG
Y
Q
A
I
F
V
MPETM
S
L
E
R
R
K
L
L
Q
A
YG
A
K
L
V
LTP---GP---DGM
K
G
A
---
I
A
K
A
E
E
-
L
A
K-E--N--N-YFV
P
Q
QFHNPANPAVH-EETT
G
P
E
I
V
E
A
FGKD---
G
-
L
-
D
A
F
I
A
GVGTGG
T
V
T
G
V
G
H
V
L
K--KNY-PD
V
K
I
Y
A
LEPE-----ESPV-----LSGG------S-----PSP
H
K
I
Q
GIGAGFVPDTLD
T
K
V
Y
D
G
I
LKVS
S
E
D
A
L
E
T
A
R
E
V
A
K
KE
G
I
L
V
GISSGA
T
I
K
A
A
L
D
L
A
-
K
--
E
-L---GA-G
K
K
V
L
A
I
V
A-SNGE
R
Y
LSTPLY-NFED----------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
92.96
73%
-95
- C2 -
2EGU
-
?
A:
[3-308]
-------------------------------------
R
T
V
N
S
I
T
E
L
I
G
D
T
P
A
V
K
L
N
R
I
-
V
--
D
----
E
D
-------
S
A
--
D
V
Y
L
K
L
E
F
M
N
P
G
S
S
V
K
D
R
I
A
L
A
M
I
E
A
A
E
K
A
G
K
L
K
P
--
G
-
D
-
T
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
V
A
A
A
K
G
Y
K
A
V
L
V
M
P
D
T
M
S
L
E
R
R
N
L
L
R
A
Y
G
A
E
L
V
L
T
P
---
G
A
---
Q
G
M
R
G
A
---
I
A
K
A
E
E
-
L
V
R
-
E
--
H
--
G
-
Y
F
M
P
---------------
T
T
G
K
E
I
V
E
Q
M
G
D
----
Q
-
L
-
D
A
F
V
A
G
V
G
T
G
G
T
I
T
G
A
G
K
V
L
R
--
E
A
Y
-
P
N
I
K
I
Y
A
V
E
P
A
-----
D
---------------------------------------
D
I
L
D
T
S
I
Y
D
G
V
I
T
V
T
T
E
E
A
F
A
A
A
R
R
A
A
R
E
E
G
I
L
G
G
I
S
S
G
A
A
I
H
A
A
L
K
V
A
-
K
--
E
-
L
---
G
K
-
G
K
K
V
L
A
I
I
P
-
S
N
G
E
R
Y
L
S
T
P
L
Y
-
Q
F
E
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.85
73%
-96
- C2 -
2EGU
-
?
A:
[6-308]
----------------------------------------
N
S
I
T
E
L
I
G
D
T
P
A
V
K
L
N
R
I
-
V
--
D
----
E
D
-------
S
A
--
D
V
Y
L
K
L
E
F
M
N
P
G
S
S
V
K
D
R
I
A
L
A
M
I
E
A
A
E
K
A
G
K
L
K
P
--
G
-
D
-
T
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
V
A
A
A
K
G
Y
K
A
V
L
V
M
P
D
T
M
S
L
E
R
R
N
L
L
R
A
Y
G
A
E
L
V
L
T
P
---
G
A
---
Q
G
M
R
G
A
---
I
A
K
A
E
E
-
L
V
R
-
E
--
H
--
G
-
Y
F
M
P
---------------
T
T
G
K
E
I
V
E
Q
M
G
-
D
---
Q
-
L
-
D
A
F
V
A
G
V
G
T
G
G
T
I
T
G
A
G
K
V
L
R
--
E
A
Y
-
P
N
I
K
I
Y
A
V
E
P
A
-----
D
---------------------------------------
D
I
L
D
T
S
I
Y
D
G
V
I
T
V
T
T
E
E
A
F
A
A
A
R
R
A
A
R
E
E
G
I
L
G
G
I
S
S
G
A
A
I
H
A
A
L
K
V
A
-
K
--
E
-
L
---
G
K
-
G
K
K
V
L
A
I
I
P
-
S
N
G
E
R
Y
L
S
T
P
L
Y
-
Q
F
E
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
90.00
51%
-72
- C2 -
3X43
1
?
A:
[2-304]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
--
E
----
H
T
-------
S
----
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
-
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
-
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
---
R
-
L
-
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
-
P
E
V
R
V
V
A
L
E
P
S
-----
N
A
A
M
-----
L
A
R
G
------
E
-----
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
-
E
--
H
-
A
---
P
E
-
G
T
V
L
L
A
M
L
P
-
D
T
G
E
R
Y
L
S
T
F
L
F
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Fugue
89.95
53%
-75
- C2 -
1OAS
1
CYSK_SALTY
A:
[1-315]
------------------------------------
S
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
----------
G
-------
N
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
-
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
D
P
Q
--
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
-
G
---
Q
-
V
-
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
-
T
D
L
I
T
V
A
V
E
P
T
-----
D
S
P
V
-----
I
A
Q
A
L
A
GE
E
I
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
-
E
D-
E
-
S
---
F
T
-
N
K
N
I
V
V
I
L
P
-
S
S
G
E
R
Y
L
S
T
A
L
F
-
A
D
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
89.42
52%
-72
* C2 *
1VE1
1
?
A:
[2-302]
-----------------------------------------
R
V
E
G
A
I
G
K
T
P
V
V
R
L
A
K
V
-
V
--
E
----
P
D
-------
M
A
--
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
GS
G
-
Q
-
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
A
---
R
E
E
A
L
R
-
L
K
E
-
E
--
L
--
G
-
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
----
R
-
I
-
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
-
P
H
V
K
V
I
A
V
E
P
A
-----
R
S
N
V
-----
L
S
G
G
------
K
-----
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
-
R
--
E
-
L
---
G
P
-
G
K
R
V
A
C
I
S
P
-
D
G
G
W
K
Y
L
S
T
P
L
Y
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
89.32
53%
-72
- C2 -
1OAS
1
CYSK_SALTY
A:
[7-311]
----------------------------------------
N
S
L
T
--
I
G
H
T
P
L
V
R
L
N
R
I
----------
G
-------
N
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
-
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
--
D
T
D
---
G
Q
V
-
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
-
T
D
L
I
T
V
A
V
E
P
T
-----
D
S
P
V
-----
I
A
Q
A
L
A
GE
E
I
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
-
E
D-
E
-
S
---
F
T
-
N
K
N
I
V
V
I
L
P
-
S
S
G
E
R
Y
L
S
T
A
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
89.25
52%
-74
- C2 -
2ECO
2
?
A:
[7-301]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
-
V
--
E
----
P
D
-------
M
A
--
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
GS
G
-
Q
-
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
A
---
R
E
E
A
L
R
-
L
K
E
-
E
--
L
--
G
-
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
-
E
G
---
R
-
I
-
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
-
P
H
V
K
V
I
A
V
E
P
A
-----
R
S
N
V
-----
L
S
G
G
------
K
-----
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
-
R
--
E
-
L
---
G
P
-
G
K
R
V
A
C
I
S
P
-
D
G
G
W
K
Y
L
S
T
P
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
89.22
51%
-75
- C2 -
3X43
1
?
B:
[2-304]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
--
E
----
H
T
-------
S
----
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
-
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
-
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
---
R
-
L
-
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
-
P
E
V
R
V
V
A
L
E
P
S
-----
N
A
A
M
-----
L
A
R
G
------
E
-----
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
-
E
--
H
-
A
---
P
E
-
G
T
V
L
L
A
M
L
P
-
D
T
G
E
R
Y
L
S
T
F
L
F
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
89.20
53%
-73
- C2 -
1OAS
1
CYSK_SALTY
B:
[7-311]
----------------------------------------
N
S
L
T
--
I
G
H
T
P
L
V
R
L
N
R
I
----------
G
-------
N
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
-
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
--
D
T
D
---
G
Q
V
-
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
-
T
D
L
I
T
V
A
V
E
P
T
-----
D
S
P
V
-----
I
A
Q
A
LAGEEI
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
-
E
D-
E
-
S
---
F
T
-
N
K
N
I
V
V
I
L
P
-
S
S
G
E
R
Y
L
S
T
A
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
89.19
52%
-72
- C2 -
2EFY
2
?
B:
[7-301]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
-
V
--
E
----
P
D
-------
M
A
--
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
GS
G
-
Q
-
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
A
---
R
E
E
A
L
R
-
L
K
E
-
E
--
L
--
G
-
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
-
E
G
---
R
-
I
-
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
-
P
H
V
K
V
I
A
V
E
P
A
-----
R
S
N
V
-----
L
S
G
G
------
K
-----
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
-
R
--
E
-
L
---
G
P
-
G
K
R
V
A
C
I
S
P
-
D
G
G
W
K
Y
L
S
T
P
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
89.16
51%
-74
- C2 -
3X43
1
?
G:
[2-304]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
--
E
----
H
T
-------
S
----
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
-
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
-
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
---
R
-
L
-
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
-
P
E
V
R
V
V
A
L
E
P
S
-----
N
A
A
M
-----
L
A
R
G
------
E
-----
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
-
E
--
H
-
A
---
P
E
-
G
T
V
L
L
A
M
L
P
-
D
T
G
E
R
Y
L
S
T
F
L
F
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
89.14
55%
-70
- C2 -
1Z7W
2
CYSK1_ARATH
A:
[3-311]
------------------------------------
S
R
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
-
A
--
E
----
G
C
-------
V
G
--
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
G-
E
-
S
-
V
L
-
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
G
M
K
G
A
---
I
A
K
A
E
E
-
I
L
A
-
K
T-
P
--
N
-
G
Y
M
L
Q
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
----
K
-
I
-
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
--
E
Q
N
-
A
N
V
K
L
Y
G
V
E
P
V
-----
E
S
A
I
-----
L
S
G
G
------
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
-
Q
--
R
-
P
E--
N
A
-
G
K
L
F
V
A
I
F
P
-
S
F
G
E
R
Y
L
S
T
V
L
F
-
D
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
89.12
52%
-72
- C2 -
2EFY
2
?
A:
[7-301]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
-
V
--
E
----
P
D
-------
M
A
--
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
GS
G
-
Q
-
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
A
---
R
E
E
A
L
R
-
L
K
E
-
E
--
L
--
G
-
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
-
E
G
---
R
-
I
-
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
-
P
H
V
K
V
I
A
V
E
P
A
-----
R
S
N
V
-----
L
S
G
G
------
K
-----
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
-
R
--
E
-
L
---
G
P
-
G
K
R
V
A
C
I
S
P
-
D
G
G
W
K
Y
L
S
T
P
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
89.08
52%
-72
- C2 -
2ECQ
2
?
A:
[7-301]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
-
V
--
E
----
P
D
-------
M
A
--
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
GS
G
-
Q
-
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
A
---
R
E
E
A
L
R
-
L
K
E
-
E
--
L
--
G
-
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
-
E
G
---
R
-
I
-
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
-
P
H
V
K
V
I
A
V
E
P
A
-----
R
S
N
V
-----
L
S
G
G
------
K
-----
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
-
R
--
E
-
L
---
G
P
-
G
K
R
V
A
C
I
S
P
-
D
G
G
W
K
Y
L
S
T
P
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
88.94
53%
-63
- C2 -
1D6S
2
CYSK_SALTY
B:
[7-311]
----------------------------------------
N
S
L
T
--
I
G
H
T
P
L
V
R
L
N
R
I
----------
G
-------
N
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
-
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
--
D
T
D
---
G
Q
V
-
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
-
T
D
L
I
T
V
A
V
E
P
T
-----
D
S
P
V
-----
I
A
Q
A
LAGEEI
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
-
E
D-
E
-
S
---
F
T
-
N
K
N
I
V
V
I
L
P
-
S
S
G
E
R
Y
L
S
T
A
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
88.80
52%
-73
- C2 -
1VE1
1
?
A:
[7-301]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
-
V
--
E
----
P
D
-------
M
A
--
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
GS
G
-
Q
-
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
A
---
R
E
E
A
L
R
-
L
K
E
-
E
--
L
--
G
-
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
-
E
G
---
R
-
I
-
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
-
P
H
V
K
V
I
A
V
E
P
A
-----
R
S
N
V
-----
L
S
G
G
------
K
-----
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
-
R
--
E
-
L
---
G
P
-
G
K
R
V
A
C
I
S
P
-
D
G
G
W
K
Y
L
S
T
P
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
88.79
51%
-73
- C2 -
3X43
1
?
C:
[2-304]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
--
E
----
H
T
-------
S
----
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
-
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
-
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
---
R
-
L
-
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
-
P
E
V
R
V
V
A
L
E
P
S
-----
N
A
A
M
-----
L
A
R
G
------
E
-----
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
-
E
--
H
-
A
---
P
E
-
G
T
V
L
L
A
M
L
P
-
D
T
G
E
R
Y
L
S
T
F
L
F
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
88.65
55%
-69
- C2 -
1O58
2
?
A:
[12-303]
----------------------------------------
H
M
M
E
R
L
I
G
S
T
P
I
V
R
L
D
S
I
-
D
-----------------
S
--
R
I
F
L
K
L
E
K
N
N
P
G
G
S
V
K
D
R
P
A
L
F
M
I
L
D
A
E
K
R
G
L
L
----
K
-
N
-
G
I
-
V
-
E
P
T
S
G
N
M
G
I
A
I
A
M
I
G
A
K
R
G
H
R
V
I
L
T
M
P
E
T
M
S
V
E
R
R
K
V
L
K
M
L
G
A
E
L
V
L
T
P
---
G
E
---
L
G
M
K
G
A
---
V
E
K
A
L
E
-
I
S
R
-
E
--
T
--
G
-
A
H
M
L
N
Q
F
E
N
P
Y
N
V
Y
S
H
-
Q
F
T
T
G
P
E
I
L
K
Q
M
D
Y
----
Q
-
I
-
D
A
F
V
A
G
V
G
T
G
G
T
I
S
G
V
G
R
V
L
K
--
G
F
F
G
N
G
V
K
I
V
A
V
E
P
A
-----
K
S
P
V
-----
L
S
G
G
------
Q
-----
P
G
K
H
A
I
Q
G
I
G
A
G
F
V
P
K
I
L
D
R
S
V
I
D
E
V
I
T
V
E
D
E
E
A
Y
E
M
A
R
Y
L
A
K
K
E
G
L
L
V
G
I
S
S
G
A
N
V
A
A
A
L
K
V
A
-
Q
--
K
-
L
---
G
P
-
D
A
R
V
V
T
V
A
P
-
D
H
A
E
R
Y
L
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
88.52
51%
-70
- C2 -
3X43
1
?
D:
[2-304]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
--
E
----
H
T
-------
S
----
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
-
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
-
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
---
R
-
L
-
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
-
P
E
V
R
V
V
A
L
E
P
S
-----
N
A
A
M
-----
L
A
R
G
------
E
-----
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
-
E
--
H
-
A
---
P
E
-
G
T
V
L
L
A
M
L
P
-
D
T
G
E
R
Y
L
S
T
F
L
F
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
88.49
51%
-74
- C2 -
3X43
1
?
F:
[2-304]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
--
E
----
H
T
-------
S
----
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
-
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
-
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
---
R
-
L
-
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
-
P
E
V
R
V
V
A
L
E
P
S
-----
N
A
A
M
-----
L
A
R
G
------
E
-----
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
-
E
--
H
-
A
---
P
E
-
G
T
V
L
L
A
M
L
P
-
D
T
G
E
R
Y
L
S
T
F
L
F
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
88.47
55%
-68
- C2 -
1Z7W
2
CYSK1_ARATH
A:
[5-309]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
-
A
--
E
----
G
C
-------
V
G
--
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
-
E
-
S
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
G
M
K
G
A
---
I
A
K
A
E
E
I
L
A
K
-
T
--
P
--
N
-
G
Y
M
L
Q
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
-----
I
-
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
--
E
Q
N
-
A
N
V
K
L
Y
G
V
E
P
V
-----
E
S
A
I
-----
L
S
G
G
------
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
-
Q
--
R
P
E
---
N
A
-
G
K
L
F
V
A
I
F
P
-
S
F
G
E
R
Y
L
S
T
V
L
F
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
88.43
58%
-71
- C2 -
2Q3B
5
CYSK_MYCTU
A:
[4-303]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
-
T
--
D
----
G
A
-------
V
A
--
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
-
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
A
---
I
A
K
A
E
E
-
L
A
K
-
T
--
D
--
Q
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
-
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
----
K
-
V
-
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
K
-
P
S
A
R
F
V
A
V
E
P
A
-----
A
S
P
V
-----
L
S
G
G
------
Q
-----
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
-
R
--
R
-
P
E--
N
A
-
G
K
L
I
V
V
V
L
P
-
D
F
G
E
R
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.40
58%
-65
- C2 -
2Q3D
2
CYSK_MYCTU
A:
[4-308]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
-
T
--
D
----
G
A
-------
V
A
--
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
-
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
A
---
I
A
K
A
E
E
-
L
A
K
T
D
--
Q
--
R
-
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
--
D
T
D
---
G
K
V
-
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
K
-
P
S
A
R
F
V
A
V
E
P
A
-----
A
S
P
V
-----
L
S
G
G
------
Q
-----
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
-
R
--
R
P
E
---
N
A
-
G
K
L
I
V
V
V
L
P
-
D
F
G
E
R
Y
L
S
T
P
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
88.34
53%
-62
- C2 -
1D6S
2
CYSK_SALTY
A:
[7-311]
----------------------------------------
N
S
L
T
--
I
G
H
T
P
L
V
R
L
N
R
I
----------
G
-------
N
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
-
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
--
D
T
D
---
G
Q
V
-
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
-
T
D
L
I
T
V
A
V
E
P
T
-----
D
S
P
V
-----
I
A
Q
A
L
A
GE
E
I
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
-
E
D-
E
-
S
---
F
T
-
N
K
N
I
V
V
I
L
P
-
S
S
G
E
R
Y
L
S
T
A
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
88.28
51%
-66
- C2 -
3X44
1
?
A:
[2-304]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
--
E
----
H
T
-------
S
----
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
-
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
-
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
---
R
-
L
-
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
-
P
E
V
R
V
V
A
L
E
P
S
-----
N
A
A
M
-----
L
A
R
G
------
E
-----
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
-
E
--
H
-
A
---
P
E
-
G
T
V
L
L
A
M
L
P
-
D
T
G
E
R
Y
L
S
T
F
L
F
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
88.18
55%
-68
- C2 -
2ISQ
3
CYSK1_ARATH
A:
[3-307]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
-
A
--
E
----
G
C
-------
V
G
--
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
-
E
-
S
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
G
M
K
G
A
---
I
A
K
A
E
E
I
L
A
K
-
T
--
P
--
N
-
G
Y
M
L
Q
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
-----
I
-
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
--
E
Q
N
-
A
N
V
K
L
Y
G
V
E
P
V
-----
E
S
A
I
-----
L
S
G
G
------
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
-
Q
--
R
P
E
---
N
A
-
G
K
L
F
V
A
I
F
P
-
S
F
G
E
R
Y
L
S
T
V
L
F
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
88.09
51%
-66
- C2 -
3X44
1
?
B:
[2-304]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
--
E
----
H
T
-------
S
----
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
-
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
-
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
---
R
-
L
-
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
-
P
E
V
R
V
V
A
L
E
P
S
-----
N
A
A
M
-----
L
A
R
G
------
E
-----
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
-
E
--
H
-
A
---
P
E
-
G
T
V
L
L
A
M
L
P
-
D
T
G
E
R
Y
L
S
T
F
L
F
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
87.95
55%
-64
- C2 -
1Z7Y
1
CYSK1_ARATH
A:
[5-309]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
-
A
--
E
----
G
C
-------
V
G
--
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
A
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
-
E
-
S
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
G
M
K
G
A
---
I
A
K
A
E
E
I
L
A
K
-
T
--
P
--
N
-
G
Y
M
L
Q
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
-----
I
-
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
--
E
Q
N
-
A
N
V
K
L
Y
G
V
E
P
V
-----
E
S
A
I
-----
L
S
G
G
------
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
-
Q
--
R
P
E
---
N
A
-
G
K
L
F
V
A
I
F
P
-
S
F
G
E
R
Y
L
S
T
V
L
F
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
87.66
51%
-73
- C2 -
3VBE
1
?
A:
[25-328]
--------------------------------------
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
-
T
--
E
----
G
C
-------
G
A
--
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
--
G
-
K
T
T
L
-
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
G
M
G
G
T
---
V
K
K
A
Y
E
-
L
L
E
-
N
--
T
P-
N
-
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
Q
-----
V
-
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
N
-
P
N
V
K
I
Y
G
V
E
P
S
-----
E
S
N
V
-----
L
N
G
G
------
K
-----
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
-
Q
L-
P
-
E
---
N
K
-
G
K
L
I
V
T
V
H
P
-
S
F
G
E
R
Y
L
S
S
V
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.62
58%
-67
- C2 -
2Q3B
5
CYSK_MYCTU
A:
[4-303]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
-
T
--
D
----
G
A
-------
V
A
--
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
-
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
A
---
I
A
K
A
E
E
-
L
A
K
T
D
--
Q
--
R
-
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
--
D
T
D
---
G
K
V
-
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
K
-
P
S
A
R
F
V
A
V
E
P
A
-----
A
S
P
V
-----
L
S
G
G
------
Q
-----
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
-
R
--
R
P
E
---
N
A
-
G
K
L
I
V
V
V
L
P
-
D
F
G
E
R
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
87.57
53%
-68
- C2 -
1FCJ
4
CYSK_SALTY
B:
[7-304]
----------------------------------------
N
S
L
T
--
I
G
H
T
P
L
V
R
L
N
R
I
----------
G
-------
N
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
-
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
--
D
T
D
---
G
Q
V
-
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
-
T
D
L
I
T
V
A
V
E
P
T
-----
D
S
P
V
-----
I
A
Q
A
LAGEEI
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
-
E
D-
E
-
S
---
F
T
-
N
K
N
I
V
V
I
L
P
-
S
S
G
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.57
58%
-69
- C2 -
3ZEI
4
CYSK_MYCTU
A:
[1-300]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
-
T
--
D
----
G
A
-------
V
A
--
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
-
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
A
---
I
A
K
A
E
E
-
L
A
K
T
D
--
Q
--
R
-
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
--
D
T
D
---
G
K
V
-
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
K
-
P
S
A
R
F
V
A
V
E
P
A
-----
A
S
P
V
-----
L
S
G
G
------
Q
-----
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
-
R
--
R
P
E
---
N
A
-
G
K
L
I
V
V
V
L
P
-
D
F
G
E
R
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
87.50
53%
-69
- C2 -
1FCJ
4
CYSK_SALTY
D:
[7-302]
----------------------------------------
N
S
L
T
--
I
G
H
T
P
L
V
R
L
N
R
I
----------
G
-------
N
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
-
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
--
D
T
D
---
G
Q
V
-
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
-
T
D
L
I
T
V
A
V
E
P
T
-----
D
S
P
V
-----
I
A
Q
A
LAGEEI
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
-
E
D-
E
-
S
---
F
T
-
N
K
N
I
V
V
I
L
P
-
S
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
87.34
51%
-70
- C2 -
3VBE
1
?
C:
[25-328]
--------------------------------------
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
-
T
--
E
----
G
C
-------
G
A
--
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
--
G
-
K
T
T
L
-
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
G
M
G
G
T
---
V
K
K
A
Y
E
-
L
L
E
-
N
--
T
P-
N
-
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
Q
-----
V
-
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
N
-
P
N
V
K
I
Y
G
V
E
P
S
-----
E
S
N
V
-----
L
N
G
G
------
K
-----
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
-
Q
L-
P
-
E
---
N
K
-
G
K
L
I
V
T
V
H
P
-
S
F
G
E
R
Y
L
S
S
V
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
87.11
51%
-70
- C2 -
3VBE
1
?
D:
[25-328]
--------------------------------------
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
-
T
--
E
----
G
C
-------
G
A
--
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
--
G
-
K
T
T
L
-
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
G
M
G
G
T
---
V
K
K
A
Y
E
-
L
L
E
-
N
--
T
P-
N
-
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
Q
-----
V
-
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
N
-
P
N
V
K
I
Y
G
V
E
P
S
-----
E
S
N
V
-----
L
N
G
G
------
K
-----
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
-
Q
L-
P
-
E
---
N
K
-
G
K
L
I
V
T
V
H
P
-
S
F
G
E
R
Y
L
S
S
V
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
87.04
50%
-72
- C2 -
1Y7L
2
CYSK_HAEIN
A:
[2-311]
-------------------------------------
A
I
Y
A
D
N
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
-------------
N
G
--
N
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
K
--
G
-
K
-
E
I
-
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
A
K
A
E
E
-
I
V
A
-
S
--
D
PS
R
-
Y
V
M
L
K
Q
F
E
N
P
A
N
P
Q
I
H
-
R
E
T
T
G
P
E
I
W
K
D
T
D
G
----
K
-
V
-
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
--
L
D
F
G
K
Q
I
T
S
V
A
V
E
P
V
-----
E
S
P
V
-----
I
S
Q
T
L
-----
A
GE
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
-
K
--
L
-
P
E--
F
A
-
D
K
L
I
V
V
I
L
P
-
S
A
S
E
R
Y
L
S
T
A
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
86.98
50%
-65
- C2 -
3X44
1
?
A:
[2-306]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
--
P
----
E
--------
H
T
--
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
-
T
I
-
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
---
G
H
---
L
G
S
K
G
G
---
N
L
I
A
D
E
-
L
A
E
-
K
--
Y
--
G
-
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
---
R
-
L
-
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
-
P
E
V
R
V
V
A
L
E
P
S
-----
N
A
A
M
-----
L
A
R
G
------
E
-----
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
-
E
--
H
-
A
---
P
E
-
G
T
V
L
L
A
M
L
P
-
D
T
G
E
R
Y
L
S
T
F
L
F
-
D
G
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
86.98
53%
-66
- C2 -
1FCJ
4
CYSK_SALTY
C:
[7-304]
----------------------------------------
N
S
L
T
--
I
G
H
T
P
L
V
R
L
N
R
I
----------
G
-------
N
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
-
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
--
D
T
D
---
G
Q
V
-
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
-
T
D
L
I
T
V
A
V
E
P
T
-----
D
S
P
V
-----
I
A
Q
A
LAGEEI
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
-
E
D-
E
-
S
---
F
T
-
N
K
N
I
V
V
I
L
P
-
S
S
G
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
86.88
50%
-68
- C2 -
3T4P
3
?
A:
[11-314]
--------------------------------------
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
L
-
N
--
N
----
T
--------
K
A
--
K
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
--
G
-
K
-
S
I
-
V
V
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
G
M
K
G
A
---
V
A
M
A
K
K
-
I
V
A
-
A
--
N
P-
N
-
A
V
L
A
D
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
N
-----
V
-
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
--
K
M
G
-
S
H
A
R
I
V
A
V
E
P
T
-----
E
S
P
V
-----
L
S
G
G
------
K
-----
P
G
P
H
K
I
Q
G
I
G
P
G
F
V
P
D
V
L
D
R
S
L
I
D
E
V
L
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
-
E
--
R
-
P
---
E
M
E
G
K
T
I
V
T
V
I
P
-
S
F
G
E
R
Y
L
S
T
T
L
Y
-
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
86.85
51%
-70
- C2 -
3VBE
1
?
B:
[25-328]
--------------------------------------
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
-
T
--
E
----
G
C
-------
G
A
--
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
--
G
-
K
T
T
L
-
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
G
M
G
G
T
---
V
K
K
A
Y
E
-
L
L
E
-
N
--
T
P-
N
-
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
Q
-----
V
-
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
N
-
P
N
V
K
I
Y
G
V
E
P
S
-----
E
S
N
V
-----
L
N
G
G
------
K
-----
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
-
Q
L-
P
-
E
---
N
K
-
G
K
L
I
V
T
V
H
P
-
S
F
G
E
R
Y
L
S
S
V
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
86.77
50%
-65
- C2 -
3TBH
2
?
A:
[10-317]
-------------------------------------
N
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
L
-
N
--
N
-----
T
-------
K
A
--
K
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
--
G
K
S
-
I
V
-
V
-
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
G
M
K
G
A
---
V
A
M
A
K
K
-
I
V
A
-
A
N
-
P
--
N
-
A
V
L
A
D
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
----
N
-
V
-
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
--
K
M
G
-
S
H
A
R
I
V
A
V
E
P
T
-----
E
S
P
V
-----
L
S
G
G
------
K
-----
P
G
P
H
K
I
Q
G
I
G
P
G
F
V
P
D
V
L
D
R
S
L
I
D
E
V
L
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
-
E
--
R
-
P
E--
M
E
-
G
K
T
I
V
T
V
I
P
-
S
F
G
E
R
Y
L
S
T
T
L
Y
-
R
S
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
86.54
50%
-66
- C2 -
3TBH
2
?
A:
[11-314]
--------------------------------------
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
L
-
N
--
N
----
T
--------
K
A
--
K
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
--
G
-
K
-
S
I
-
V
V
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
G
M
K
G
A
---
V
A
M
A
K
K
-
I
V
A
-
A
--
N
P-
N
-
A
V
L
A
D
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
N
-----
V
-
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
--
K
M
G
-
S
H
A
R
I
V
A
V
E
P
T
-----
E
S
P
V
-----
L
S
G
G
------
K
-----
P
G
P
H
K
I
Q
G
I
G
P
G
F
V
P
D
V
L
D
R
S
L
I
D
E
V
L
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
-
E
--
R
-
P
---
E
M
E
G
K
T
I
V
T
V
I
P
-
S
F
G
E
R
Y
L
S
T
T
L
Y
-
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
86.54
53%
-69
- C2 -
1FCJ
4
CYSK_SALTY
A:
[7-302]
----------------------------------------
N
S
L
T
--
I
G
H
T
P
L
V
R
L
N
R
I
----------
G
-------
N
G
--
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
-
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
-
I
V
A
-
S
--
D
PQ
K
-
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
--
D
T
D
---
G
Q
V
-
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
-
T
D
L
I
T
V
A
V
E
P
T
-----
D
S
P
V
-----
I
A
Q
A
L
A
GEE
I
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
-
E
D-
E
-
S
---
F
T
-
N
K
N
I
V
V
I
L
P
-
S
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
86.19
52%
-56
- C2 -
4LMB
3
?
A:
[8-317]
------------------------------------
M
L
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
I
-
P
V
A
E
----
G
V
-------
K
A
--
R
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
--
D
-
K
-
T
I
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
---
G
S
---
Q
G
M
E
G
A
---
I
T
R
A
E
E
-
I
V
E
-
N
--
T
P-
N
-
A
Y
S
L
Q
Q
F
R
N
P
A
N
P
K
I
H
-
R
E
T
T
A
E
E
I
W
A
--
D
T
D
---
G
-
L
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
--
P
R
R
-
P
Q
F
Q
A
I
A
V
E
P
S
-----
N
S
P
V
-----
L
S
G
G
------
Q
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
-
K
--
R
-
P
---
E
N
-
E
D
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
85.78
47%
-70
- C2 -
2PQM
2
?
A:
[13-323]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
--
E
HPRI
K
K
-------
G
T
--
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
-
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
-
M
I
K
-
E
--
N
PG
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
A
N
-
E
I
W
E
--
D
T
D
---
G
E
V
-
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
K
-
K
G
I
K
I
I
A
V
E
P
E
-----
E
S
A
V
-----
L
E
G
K
------
A
-----
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
--
P
-
E
---
N
E
-
G
K
T
I
V
I
I
V
P
-
S
C
G
E
R
Y
L
S
T
D
L
Y
-
K
I
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
85.70
46%
-73
- C2 -
4JBN
2
?
A:
[13-323]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
--
E
HPRI
K
K
-------
G
T
--
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
-
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
-
M
I
K
-
E
--
N
PG
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
A
N
-
E
I
W
E
--
D
T
D
---
G
E
V
-
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
K
-
K
G
I
K
I
I
A
V
E
P
E
-----
E
S
A
V
-----
L
E
G
K
------
A
-----
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
--
P
-
E
---
N
E
-
G
K
T
I
V
I
I
V
P
-
S
C
G
E
R
Y
L
S
T
D
L
Y
-
K
I
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
85.59
52%
-65
- C2 -
4AEC
4
CYSKM_ARATH
B:
[111-417]
------------------------------------
L
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
I
-
A
--
K
----
G
C
-------
V
A
--
N
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
--
G
-
K
-
S
V
L
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
---
P
A
---
K
G
M
T
G
A
---
V
Q
K
A
E
E
-
I
L
K
-
N
--
T
P-
D
-
A
Y
M
L
Q
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
D
D
-
T
K
G
---
K
-
V
-
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
--
E
K
N
-
P
K
T
Q
V
I
G
V
E
P
T
-----
E
S
D
I
-----
L
S
G
G
------
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
-
K
--
R
P
E
---
N
A
-
G
K
L
I
A
V
V
F
P
-
S
F
G
E
R
Y
L
S
T
P
L
F
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
85.54
46%
-70
- C2 -
4IL5
1
?
A:
[13-323]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
--
E
HPRI
K
K
-------
G
T
--
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
-
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
-
M
I
K
-
E
--
N
PG
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
A
N
-
E
I
W
E
--
D
T
D
---
G
E
V
-
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
K
-
K
G
I
K
I
I
A
V
E
P
E
-----
E
S
A
V
-----
L
E
G
K
------
A
-----
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
--
P
-
E
---
N
E
-
G
K
T
I
V
I
I
V
P
-
S
C
G
E
R
Y
L
S
T
D
L
Y
-
K
I
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
85.45
52%
-65
- C2 -
4LMA
3
?
A:
[8-320]
------------------------------------
M
R
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
I
-
P
--
Q
----
A
E
-------
G
C
L
G
R
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
P
--
E
-
T
-
T
V
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
---
G
S
---
Q
G
M
K
G
A
---
I
L
R
A
Q
Q
-
I
V
D
-
S
I
-
P
--
G
-
A
Y
M
L
Q
Q
F
R
N
P
S
N
P
E
I
H
-
R
L
T
T
A
E
E
I
W
Q
D
-
T
E
G
---
Q
-
V
-
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
--
S
R
K
-
P
S
F
Q
V
V
A
V
E
P
F
-----
N
S
P
V
-----
I
S
G
G
------
N
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
-
Q
--
R
P
E
---
N
E
-
G
K
L
I
V
V
I
Q
P
-
S
F
G
E
R
Y
L
S
T
L
M
F
Q
N
I
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
85.30
50%
-62
- C2 -
5DBH
2
?
X:
[17-317]
----------------------------------------------
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
----
N
G
-----------
N
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
K
--
G
-
K
-
E
I
-
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
A
K
A
E
E
-
I
V
A
-
S
--
D
PS
R
-
Y
V
M
L
K
Q
F
E
N
P
A
N
P
Q
I
H
-
R
E
T
T
G
P
E
I
----
W
K
D
TDG
K
-
V
-
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
--
L
D
F
G
K
Q
I
T
S
V
A
V
E
P
V
-----
E
S
P
V
-----
I
S
Q
T
LAGEEV
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
-
K
LP
E
-
F
----
A
-
D
K
L
I
V
V
I
L
P
-
S
A
S
E
R
Y
L
S
T
A
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
85.00
47%
-74
- C2 -
2PQM
2
?
B:
[13-323]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
--
E
HPRI
K
K
-------
G
T
--
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
-
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
-
M
I
K
-
E
--
N
PG
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
A
N
-
E
I
W
E
--
D
T
D
---
G
E
V
-
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
K
-
K
G
I
K
I
I
A
V
E
P
E
-----
E
S
A
V
-----
L
E
G
K
------
A
-----
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
--
P
-
E
---
N
E
-
G
K
T
I
V
I
I
V
P
-
S
C
G
E
R
Y
L
S
T
D
L
Y
-
K
I
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
84.83
47%
-72
- C2 -
2PQM
2
?
A:
[12-322]
-------------------------------------
R
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
--
E
----
H
P
RIKK---
G
T
--
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
-
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
-
M
I
K
-
E
--
N
P-
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
-
A
A
-
H
H
Y
T
A
N
E
I
W
E
D
T
D
G
----
E
-
V
-
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
K
-
K
G
I
K
I
I
A
V
E
P
E
-----
E
S
A
V
-----
L
E
G
K
------
A
-----
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
-
E
--
K
-
P
E--
N
E
-
G
K
T
I
V
I
I
V
P
-
S
C
G
E
R
Y
L
S
T
D
L
Y
-
K
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
84.71
47%
-70
- C2 -
3BM5
4
?
A:
[12-322]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
--
E
HPRI
K
K
-------
G
T
--
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
-
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
-
M
I
K
-
E
--
N
PG
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
A
N
-
E
I
W
E
--
D
T
D
---
G
E
V
-
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
K
-
K
G
I
K
I
I
A
V
E
P
E
-----
E
S
A
V
-----
L
E
G
K
------
A
-----
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
--
P
-
E
---
N
E
-
G
K
T
I
V
I
I
V
P
-
S
C
G
E
R
Y
L
S
T
D
L
Y
-
K
I
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
84.28
52%
-66
- C2 -
4AEC
3
CYSKM_ARATH
A:
[111-417]
------------------------------------
L
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
I
-
A
--
K
----
G
C
-------
V
A
--
N
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
--
G
-
K
-
S
V
L
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
---
P
A
---
K
G
M
T
G
A
---
V
Q
K
A
E
E
-
I
L
K
-
N
--
T
P-
D
-
A
Y
M
L
Q
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
D
D
-
T
K
G
---
K
-
V
-
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
--
E
K
N
-
P
K
T
Q
V
I
G
V
E
P
T
-----
E
S
D
I
-----
L
S
G
G
------
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
-
K
--
R
P
E
---
N
A
-
G
K
L
I
A
V
V
F
P
-
S
F
G
E
R
Y
L
S
T
P
L
F
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
84.06
52%
-63
- C2 -
4LMA
2
?
B:
[8-319]
------------------------------------
M
R
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
I
-
P
--
Q
----
A
E
-------
G
C
LG
R
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
P
--
E
-
T
-
T
V
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
---
G
S
---
Q
G
M
K
G
A
---
I
L
R
A
Q
Q
-
I
V
D
-
S
I-
P
--
G
-
A
Y
M
L
Q
Q
F
R
N
P
S
N
P
E
I
H
-
R
L
T
T
A
E
E
I
W
Q
D
-
T
E
G
---
Q
-
V
-
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
--
S
R
K
-
P
S
F
Q
V
V
A
V
E
P
F
-----
N
S
P
V
-----
I
S
G
G
------
N
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
-
Q
--
R
P
E
---
N
E
-
G
K
L
I
V
V
I
Q
P
-
S
F
G
E
R
Y
L
S
T
L
M
F
Q
N
I
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
83.54
41%
-63
- C2 -
4COO
9
CBS_HUMAN
A:
[106-408]
----------------------------------------------
I
G
D
T
P
M
V
R
I
N
K
I
-
G
--
K
----
K
F
GL-----
K
C
--
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
-
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
S
P
E
S
H
---
V
G
V
A
W
R
-
L
K
N
-
E
I
-
P
--
N
-
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
--
D
---
G
K
L
-
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
-
P
G
C
R
I
I
G
V
D
P
E
GSILA
E
P
E
E
-----
L
N
Q
T
------
E
-----
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
-
Q
--
E
-
L
---
Q
E
-
G
Q
R
C
V
V
I
L
P
-
D
S
V
R
N
Y
M
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
83.48
46%
-64
- C2 -
4JBL
2
?
B:
[13-323]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
--
E
HPRI
K
K
-------
G
T
--
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
-
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
-
M
I
K
-
E
--
N
PG
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
A
N
-
E
I
W
E
--
D
T
D
---
G
E
V
-
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
K
-
K
G
I
K
I
I
A
V
E
P
E
-----
E
S
A
V
-----
L
E
G
K
------
A
-----
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
--
P
-
E
---
N
E
-
G
K
T
I
V
I
I
V
P
-
S
C
G
E
R
Y
L
S
T
D
L
Y
-
K
I
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
83.45
41%
-63
- C2 -
4COO
6
CBS_HUMAN
B:
[106-414]
----------------------------------------------
I
G
D
T
P
M
V
R
I
N
K
I
-
G
--
K
----
K
F
GL-----
K
C
--
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
-
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
S
P
E
S
H
---
V
G
V
A
W
R
-
L
K
N
-
E
I
-
P
--
N
-
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
--
D
---
G
K
L
-
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
-
P
G
C
R
I
I
G
V
D
P
E
GSILA
E
P
E
E
-----
L
N
Q
T
------
E
-----
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
-
Q
--
E
-
L
---
Q
E
-
G
Q
R
C
V
V
I
L
P
-
D
S
V
R
N
Y
M
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
83.36
49%
-80
- C2 -
4AIR
5
?
B:
[32-335]
--------------------------------------
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
L
-
N
--
N
----
T
--------
K
A
--
K
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
--
G
-
K
-
S
V
-
V
V
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
G
M
K
G
A
---
V
T
M
A
K
K
-
I
V
T
-
A
--
N
P-
N
-
A
V
L
A
D
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
N
-----
V
-
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
--
K
M
G
-
S
H
A
R
I
V
A
V
E
P
M
-----
E
------------------------------------------
D
R
S
L
I
D
E
V
F
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
-
E
RP
E
-
M
----
E
-
G
K
T
I
V
T
I
I
P
-
S
F
G
E
R
Y
L
S
T
A
L
Y
-
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
83.32
47%
-63
- C2 -
3BM5
4
?
B:
[12-322]
--------------------------------------
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
--
E
HPRI
K
K
-------
G
T
--
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
-
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
-
M
I
K
-
E
--
N
PG
K
-
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
A
N
-
E
I
W
E
--
D
T
D
---
G
E
V
-
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
K
-
K
G
I
K
I
I
A
V
E
P
E
-----
E
S
A
V
-----
L
E
G
K
------
A
-----
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
K
--
P
-
E
---
N
E
-
G
K
T
I
V
I
I
V
P
-
S
C
G
E
R
Y
L
S
T
D
L
Y
-
K
I
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
83.30
41%
-63
- C2 -
4L0D
2
CBS_HUMAN
A:
[84-392]
----------------------------------------------
I
G
D
T
P
M
V
R
I
N
K
I
-
G
--
K
----
K
F
GL-----
K
C
--
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
-
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
S
P
E
S
H
---
V
G
V
A
W
R
-
L
K
N
-
E
I
-
P
--
N
-
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
--
D
---
G
K
L
-
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
-
P
G
C
R
I
I
G
V
D
P
E
GSILA
E
P
E
E
-----
L
N
Q
T
------
E
-----
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
-
Q
--
E
-
L
---
Q
E
-
G
Q
R
C
V
V
I
L
P
-
D
S
V
R
N
Y
M
T
K
F
L
S
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
83.15
41%
-65
- C2 -
4L0D
2
CBS_HUMAN
B:
[84-391]
----------------------------------------------
I
G
D
T
P
M
V
R
I
N
K
I
-
G
--
K
----
K
F
GL-----
K
C
--
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
-
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
---
T
N
ARF
D
S
P
E
S
H
---
V
G
V
A
W
R
-
L
K
N
-
E
I
-
P
--
N
-
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
--
D
---
G
K
L
-
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
-
P
G
C
R
I
I
G
V
D
P
E
GSILA
E
P
E
E
-----
L
N
Q
T
------
E
-----
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
-
Q
--
E
-
L
---
Q
E
-
G
Q
R
C
V
V
I
L
P
-
D
S
V
R
N
Y
M
T
K
F
L
S
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
82.83
42%
-64
- C2 -
3DWG
1
CYSM_MYCTU
A:
[3-311]
------------------------------------
M
T
R
Y
D
S
L
L
Q
A
L
G
N
T
P
L
V
G
L
Q
R
L
-
S
--
P
----
R
W
DDGRD
G
P
H
V
--
R
L
W
A
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
L
L
R
P
--
G
-
A
-
T
I
-
L
-
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
F
S
A
---
A
E
---
G
G
S
N
T
A
---
V
A
T
A
K
E
-
L
A
A
-
T
--
N
P-
S
-
W
V
M
L
Y
Q
Y
G
N
P
A
N
T
D
S
H
-
Y
C
G
T
G
P
E
L
L
A
D
L
P
-----
E
-
I
-
T
H
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
--
E
H
V
-
A
N
V
K
I
V
A
A
E
P
R
-----
Y
G
E
G
-----
V
Y
A
------------------
L
R
N
M
D
E
G
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
V
L
H
A
A
L
G
V
G
-
A
--
G
-
A
L
A
A
G
E
-
R
A
D
I
A
L
V
V
A
-
D
A
G
W
K
Y
L
S
T
G
A
Y
-
A
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
123
Fugue
81.32
40%
-56
- C2 -
3PC3
2
?
A:
[12-515]
YERPADFIDPGKPSKCKWHLGTAEKSP
H
I
H
R
G
I
AHR
Q
Q
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
-
P
--
A
----
S
D
GI-----
E
C
--
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
--
G
-
Y
-
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
TEA
A
Y
---
D
S
P
E
G
L
---
I
Y
V
A
Q
Q
-
L
Q
R
-
E
T
-
P
--
N
-
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
-
N
---
K
-
V
-
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
V
-
P
S
C
Q
I
V
G
V
D
P
Y
-----
G
S
I
L
ARPAE
L
N
K
T
------
D
-----
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
-
R
--
K
-
L
---
K
K
-
G
Q
R
C
V
V
I
L
P
-
D
G
I
R
N
Y
M
T
-----
K
F
V
S
D
N
W
M
E
A
R
NF
K
E
P
V
NEHGHWWWSLAIAELELPAPP
V
I
L
K
SDAT
V
G
E
A
I
A
L
M
K
K
H
RVD
Q
L
P
V
V
D
QDDGSVL
G
V
V
G
Q
E
T
L
I
T
Q
I
VSMNRQQSDPAIKALNKRV
I
R
L
N
ESEI
L
G
K
L
A
R
V
L
E
V
DP
S
V
L
I
L
G
K
N
PAG
K
V
E
L
K
A
L
A
T
K
L
D
V
T
T
F
I
A
A
GKQK
113
HHSearch
79.45
39%
-59
- C2 -
3PC3
2
?
A:
[50-364]
--------------------------------------
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
-
P
--
A
----
S
D
GI-----
E
C
--
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
--
G
-
Y
-
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
---
T
E
---
A
A
Y
D
S
P
EG
L
I
Y
V
A
Q
Q
-
L
Q
R
-
E
--
T
P-
N
-
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
----
K
-
V
-
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
V
-
P
S
C
Q
I
V
G
V
D
P
Y
-----
G
S
I
L
-----
A
R
P
A
ELNKT-
D
-----
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
-
R
--
K
-
L
---
K
K
-
G
Q
R
C
V
V
I
L
P
-
D
G
I
R
N
Y
M
T
K
F
V
S
-
D
N
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
78.55
43%
-69
- C2 -
2BHS
1
CYSM_ECOLI
B:
[2-292]
----------------------------------------
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
G
P
--
D
----
N
G
-------
S
---
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
-
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
A
---
R
D
L
A
L
E
-
M
A
N
-
R
--
G
--
E
-
G
K
L
L
D
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
-----
I
-
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
-
K
P
V
T
I
V
G
L
Q
P
E
-----
E
G
S
S
-----
I
P
G
I
------
R
-----
R
W
P
T
E
-------
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
-
K
--
A
-----
N
P
-
D
A
V
V
V
A
I
I
C
-
D
R
G
D
R
Y
L
S
T
G
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
78.40
42%
-68
- C2 -
2V03
3
CYSM_ECOLI
A:
[2-294]
----------------------------------------
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
G
P
--
D
----
N
G
-------
S
---
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
-
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
A
---
R
D
L
A
L
E
-
M
A
N
-
R
--
G
--
E
-
G
K
L
L
D
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
-----
I
-
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
-
K
P
V
T
I
V
G
L
Q
P
E
-----
E
G
S
S
-----
I
P
G
I
------
R
-----
R
W
P
T
E
-------
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
-
A
--
A
-----
N
P
-
D
A
V
V
V
A
I
I
C
-
D
R
G
D
R
Y
L
S
T
G
V
F
-
G
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
78.39
43%
-68
- C2 -
2BHS
1
CYSM_ECOLI
C:
[2-292]
----------------------------------------
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
G
P
--
D
----
N
G
-------
S
---
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
-
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
A
---
R
D
L
A
L
E
-
M
A
N
-
R
--
G
--
E
-
G
K
L
L
D
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
-----
I
-
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
-
K
P
V
T
I
V
G
L
Q
P
E
-----
E
G
S
S
-----
I
P
G
I
------
R
-----
R
W
P
T
E
-------
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
-
K
--
A
-----
N
P
-
D
A
V
V
V
A
I
I
C
-
D
R
G
D
R
Y
L
S
T
G
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
77.90
43%
-66
- C2 -
2BHS
1
CYSM_ECOLI
A:
[2-293]
----------------------------------------
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
G
P
--
D
----
N
G
-------
S
---
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
-
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
A
---
R
D
L
A
L
E
-
M
A
N
-
R
--
G
--
E
-
G
K
L
L
D
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
-----
I
-
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
-
K
P
V
T
I
V
G
L
Q
P
E
-----
E
G
S
S
-----
I
P
G
I
------
R
-----
R
W
P
T
E
-------
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
-
K
--
A
-----
N
P
-
D
A
V
V
V
A
I
I
C
-
D
R
G
D
R
Y
L
S
T
G
V
F
-
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
77.49
43%
-67
- C2 -
2BHS
1
CYSM_ECOLI
D:
[2-292]
----------------------------------------
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
G
P
--
D
----
N
G
-------
S
---
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
-
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
A
---
R
D
L
A
L
E
-
M
A
N
-
R
--
G
--
E
-
G
K
L
L
D
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
-----
I
-
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
-
K
P
V
T
I
V
G
L
Q
P
E
-----
E
G
S
S
-----
I
P
G
I
------
R
-----
R
W
P
T
E
-------
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
-
K
--
A
-----
N
P
-
D
A
V
V
V
A
I
I
C
-
D
R
G
D
R
Y
L
S
T
G
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
53.52
50%
27
- C2 -
4ZU6
2
CYSK_HAEIN
X:
[27-327]
----------------------------------------------
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
----
N
G
-----------
N
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
K
--
G
-
K
-
E
I
-
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
E
---
G
A
---
K
G
--
G
A
---
I
A
K
A
E
E
-
I
V
A
-
S
--
D
PS
R
-
Y
V
M
L
K
Q
F
E
N
P
A
N
P
Q
I
H
-
R
E
T
T
G
P
E
I
W
K
D
T
-
D
G
---
K
-
V
-
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
--
L
D
F
G
K
Q
I
T
S
V
A
V
E
P
V
-----
E
S
P
V
-----
I
S
Q
T
LAGEEV
K
-----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
-
K
LP
E
-
F
----
A
-
D
K
L
I
V
V
I
L
P
-
S
A
S
E
R
Y
L
S
T
A
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------