@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0588: (2016-03-17 )
MTSVMWFRRDLRVNDNKALYHACKEDDLLLLFQVNPAQFITGSPSHQAFFASVAHFKQEVDKTALLQIMFGEPVECLKQLKETLPSWDKVYFNRDETGYGAERDEAAKTFFDEQEIEVQAFHDSYLHSAEEVKKSPTEYYKIFTPYYKKWREEIKETPFKVTLKADNIRKENLFPKYEEQFAEMTCDLPILDSGEKTANTRLANFIKHDVADYDKARDFPELDKTSHLSRYLRTGEISVRTIWQALQENEATEGRAIFEKELCWRDFYNMIYVSFPNQKNEPIQENYRFIEWENNREFFKAWQEGKTGFPLVDAAMRQLKETGWMHNRLRMVTASFLTKDLLIDWRFGEKYFQQMLIDYDPASNIGGWQWAASTGTDAVPYFRIFNPTTQSQKFDPTGKFIRKYVKELANLPDKFIHQPEKMSEIEQKEYGLLLGKDYPFPLIDHKERRKLAIARYEFSKEHYRGNI
Atome Classification :
(21 SA)
.........10........20.-...-.--.--..30......---.--..40---.--.-.--.....50-----------....-----....60-..--.-.-.....70..------.......80......--..90........100.......110.....---..120.......130.......140.......-----150....--...160-------.---------......--..170-..----------.---.....-----------180-.--.---..---..---..190.---......200.......--210......-.220.......230.......240...---------.---.-------..-------.----------250....--...260.....-..270.....-.---.-280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410..-.....420.......430.......440.....----..450.......460.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
S
V
M
W
F
R
R
DLRVNDN
K
A
L
Y
H
A-CKE-D--
D
--
L
L
L
-
L
F
QV
N
P
---
A
--
Q
F
IT---G--S-P--
S
H
Q
A
F
F
A
-----------
S
V
A
H
-----
F
K
Q
E
V
--
D
K
--
T
-
A
-
L
L
Q
I
MF-G
E
------
P
V
E
C
L
K
Q
L
K
E
TLPS
W
--
D
K
V
Y
FNRDETGYGA
E
R
D
E
A
A
K
T
FFDEQ
E
I
E
---
V
Q
A
F
H
D
S
Y
L
H
S
A
E
E
V
KKSPT
E
Y
Y
K
IF
T
P
Y
Y
K
K
-----
W
R
E
E
I
KE--TP
F
K
---------
V
---------
T
L
KADN--IRKE--NL----------F---
P
K
Y
E
E
-----------
Q
F
--
A
--
E
---
M
T---CD---LPILDS---GEKT
A
N
T
R
L
A
N
F
I
K
H
D
--V
A
D
Y
D
K
ARD-FPEL
D
K
T
S
H
L
S
R
Y
L
R
TGE
I
S
V
R
-
T
I
W
Q
---------
A
---
L
-------
Q
E-------N----------EATEG
R
A
--
I
F
E
K
E
L
C
W
R
D
F
-
Y
N
M
I
Y
V
SFPN-Q---K-NE
P
I
Q
EN
Y
R
F
I
E
WENN
R
E
F
F
K
A
W
QEGKTGF
P
L
V
D
A
A
M
R
Q
L
K
E
TGW
M
H
N
R
L
R
M
V
T
A
S
F
L
T
K
D
L
L
I
D
W
R
F
G
E
K
Y
F
Q
Q
M
L
IDYDPASNIG
G
W
Q
W
AASTGTDA
V
P
Y
F
R
I
FNPTTQSQKFD
P
T
G
K
F
I
R
K
Y
V
K
E
L
ANL
P
D
K
-
F
IHQ
P
E
K
M
S
E
I
E
Q
KEY
G
L
L
LGKDYPFPLI
D
H
K
E
----
R
R
K
L
A
I
A
R
Y
EF
S
K
E
H
YRGNI
21
PsiBlast_CBE
91.25
38%
-57
- C4 -
1DNP
2
PHR_ECOLI
B:
[2-469]
-
T
H
L
V
W
F
R
Q
D
L
R
L
H
D
N
L
A
L
A
A
A
-
C
R
N
-
S
--
S
AR
V
L
A
-
L
Y
I
A
T
P
---
R
--
Q
W
A
T
---
H
NM
S
-
P
--
R
Q
A
E
L
I
N
-----------
A
Q
L
N
-----
G
L
Q
I
A
--
L
A
--
E
-
K
-
G
I
P
L
L
F
-
R
E
VDDFVA
S
V
E
I
V
K
Q
V
C
A
E
-
N
S
V
--
T
H
L
F
Y
N
-----
Y
Q
Y
E
V
N
E
R
A
R
D
V
E
V
E
R
A
L
R
NVV
C
E
G
F
D
D
S
V
I
L
P
P
G
A
V
M
T
G
N
H
E
M
Y
K
V
F
T
P
F
K
N
A
-----
W
L
K
R
L
R
E
--
G
-
M
P
---------
E
---------
C
V
A
A
P
K
--
V
R
S
S
--
G
S
----------
I
EPS
P
S
I
T
L
-----------
N
Y
--
P
--
R
---
Q
S
---
F
D
---
T
A
H
F
P
V
---
E
E
K
A
A
I
A
Q
L
R
Q
F
C
Q
N
G
--
A
G
E
Y
E
Q
Q
R
D
-
F
P
A
V
E
G
T
S
R
L
S
A
S
L
A
T
G
G
L
S
P
R
-
Q
C
L
H
---------
R
---
L
LA-----
E
Q
-------
P
----------
Q
A
L
D
G
G
A
GS
V
W
L
N
E
L
I
W
R
E
F
-
Y
R
H
L
I
T
Y
H
P
S
L
C
---
K
-
H
R
P
F
I
A
W
T
D
R
V
Q
W
Q
S
N
P
A
H
L
Q
A
W
Q
E
G
K
T
G
Y
P
I
V
D
A
A
M
R
Q
L
N
S
T
G
W
M
H
N
R
L
R
M
I
T
A
S
F
L
V
K
D
L
L
I
D
W
R
E
G
E
R
Y
F
M
S
Q
L
I
D
G
D
L
A
A
N
N
G
G
W
Q
W
A
A
S
T
G
T
D
A
A
P
Y
F
R
I
F
N
P
T
T
Q
G
E
K
F
D
H
E
G
E
F
I
R
Q
W
L
P
E
L
R
D
V
P
G
K
-
V
V
H
E
P
W
K
W
A
Q
----
K
A
G
V
T
L
--
D
Y
P
Q
P
I
V
E
H
K
E
----
A
R
V
Q
T
L
A
A
Y
E
A
A
R
K
------
1
PsiBlast_PDB
90.60
38%
-56
- C4 -
1DNP
2
PHR_ECOLI
A:
[2-469]
-
T
H
L
V
W
F
R
Q
D
L
R
L
H
D
N
L
A
L
A
A
A
-
C
R
N
-
S
--
S
A
R
V
L
A
-
L
Y
I
A
T
P
---
R
--
Q
W
A
T
---
H
NM
S
-
P
--
R
Q
A
E
L
I
N
-----------
A
Q
L
N
-----
G
L
Q
I
A
--
L
A
--
E
-
K
-
G
I
P
L
L
F
-
R
E
V
DD
F
V
A
S
V
E
I
V
K
Q
V
C
A
E
-
N
S
V
--
T
H
L
F
Y
N
-----
Y
Q
Y
E
V
N
E
R
A
R
D
V
E
V
E
R
A
L
R
N
V
V
C
E
G
F
D
D
S
V
I
L
P
P
G
A
V
M
T
G
N
H
E
M
Y
K
V
F
T
P
F
K
N
A
-----
W
L
K
R
L
R
E
--
G
-
M
P
---------
E
---------
C
V
A
A
P
K
--
V
R
S
S
--
G
S
----------
I
E
P
S
P
S
I
T
L
-----------
N
Y
--
P
--
R
---
Q
S
---
F
D
---
T
A
H
F
P
V
---
E
E
K
A
A
I
A
Q
L
R
Q
F
C
Q
N
G
--
A
G
E
Y
E
Q
Q
R
D
-
F
P
A
V
E
G
T
S
R
L
S
A
S
L
A
T
G
G
L
S
P
R
-
Q
C
L
H
---------
R
---
L
L
A
-----
E
Q
-------
P
----------
Q
A
L
D
G
G
A
G
S
V
W
L
N
E
L
I
W
R
E
F
-
Y
R
H
L
I
T
Y
H
P
S
L
C
---
K
-
H
R
P
F
I
A
W
T
D
R
V
Q
W
Q
S
N
P
A
H
L
Q
A
W
Q
E
G
K
T
G
Y
P
I
V
D
A
A
M
R
Q
L
N
S
T
G
W
M
H
N
R
L
R
M
I
T
A
S
F
L
V
K
D
L
L
I
D
W
R
E
G
E
R
Y
F
M
S
Q
L
I
D
G
D
L
A
A
N
N
G
G
W
Q
W
A
A
S
T
G
T
D
A
A
P
Y
F
R
I
F
N
P
T
T
Q
G
E
K
F
D
H
E
G
E
F
I
R
Q
W
L
P
E
L
R
D
V
P
G
K
-
V
V
H
E
P
W
K
W
A
Q
----
K
A
G
V
T
L
--
D
Y
P
Q
P
I
V
E
H
K
E
----
A
R
V
Q
T
L
A
A
Y
E
A
A
R
K
------
34
HHSearch
90.49
36%
-51
- C4 -
1OWL
3
PHR_SYNP6
A:
[3-474]
A
P
I
L
F
W
H
R
R
D
L
R
L
S
D
N
I
G
L
A
A
A
-
R
A
Q
-
S
A-
Q
--
L
I
G
-
L
F
C
L
D
P
---
Q
--
I
L
Q
S
---
A
--
D
M
A
P
A
R
V
A
Y
L
Q
G
-----------
C
L
Q
E
-----
L
Q
Q
R
Y
--
Q
Q
--
A
G
S
-
R
L
L
L
L
Q
-
G
D
------
P
Q
H
L
I
P
Q
L
A
Q
Q
L
-
Q
A
--
E
A
V
Y
W
N
Q
D
I
E
P
Y
G
R
D
R
D
G
Q
V
A
A
A
L
K
T
A
G
I
R
---
A
V
Q
L
W
D
Q
L
L
H
S
P
D
Q
I
L
S
G
S
G
N
P
Y
S
V
Y
G
P
F
W
K
N
-----
W
Q
A
Q
P
K
P
--
T
P
V
A
---------
T
---------
P
T
E
L
V
D
--
L
S
P
E
Q
L
T
A
----------
I
APL
L
L
S
E
L
-----------
P
T
--
L
K-
Q
---
L
G
FDW
D
G
---
G
F
P
V
E
P
---
G
E
T
A
A
I
A
R
L
Q
E
F
C
D
R
A
--
I
A
D
Y
D
P
Q
R
N
-
F
P
A
E
A
G
T
S
G
L
S
P
A
L
K
F
G
A
I
G
I
R
-
Q
A
W
Q
---------
A
---
A
-------
S
A
-------
A
H
A
L
SRS
D
---
E
A
R
N
S
I
R
--
V
W
Q
Q
E
L
A
W
R
E
F
-
Y
Q
H
A
L
Y
H
F
P
S
-
L
---
A
-
D
G
P
Y
R
S
L
W
Q
Q
F
P
W
E
N
R
E
A
L
F
T
A
W
T
Q
A
Q
T
G
Y
P
I
V
D
A
A
M
R
Q
L
T
E
T
G
W
M
H
N
R
C
R
M
I
V
A
S
F
L
T
K
D
L
I
I
D
W
R
R
G
E
Q
F
F
M
Q
H
L
V
D
G
D
L
A
A
N
N
G
G
W
Q
W
S
A
S
S
G
M
D
P
K
P
-
L
R
I
F
N
P
A
S
Q
A
K
K
F
D
A
T
A
T
Y
I
K
R
W
L
P
E
L
R
H
V
H
P
K
D
L
I
S
G
E
I
-
T
P
I
---------
E
R
R
G
Y
P
A
P
I
V
N
H
N
L
----
R
Q
K
Q
F
K
A
L
Y
N
Q
L
K
A
A
-----
41
Fugue
89.47
38%
-52
- C4 -
1DNP
2
PHR_ECOLI
A:
[1-469]
T
T
H
L
V
W
F
R
Q
D
L
R
L
H
D
N
L
A
L
A
A
A
-
C
R
N
-
S
S
A
R
--
V
L
A
-
L
Y
I
A
T
P
---
R
--
Q
W
A
T
H
NM
S
--
P
-
R
--
Q
A
E
L
I
N
A
-----------
Q
L
N
G
-----
L
Q
I
A
L
--
A
E
K
G
I
-
P
-
L
L
F
R
E
V
-
D
D
------
F
V
A
S
V
E
I
V
K
Q
V
C
A
E
N
SV
T
H
L
F
Y
N
Y
Q
Y
E
V
N
E
R
A
R
D
V
E
V
E
R
A
L
R
--
N
V
V
---
C
E
G
F
D
D
S
V
I
L
P
P
G
A
V
M
T
G
N
H
E
M
Y
K
V
F
T
P
F
K
N
A
-----
W
L
K
R
L
R
E
--
G
M
P
E
C
V
A
APKVRS---------------
S
--
G
S
I
E
--
P
S
----------
P
---
S
I
T
L
------------
N
Y
--
P
--
R
---
Q
S
---
F
D
---
T
A
H
F
P
V
---
E
E
K
A
A
I
A
Q
L
R
Q
F
C
Q
N
G
--
A
G
E
Y
E
Q
Q
R
D
-
F
P
A
V
E
G
T
S
R
L
S
A
S
L
A
T
G
G
L
S
P
R
-
Q
C
L
H
---------
R
---
L
-------
L
A
E
QPQALD-------------
G
G
A
G
S
--
V
W
L
N
E
L
I
W
R
E
F
-
Y
R
H
L
I
T
Y
H
P
S
-
L
---
C
K
H
R
P
F
I
A
W
T
D
R
V
Q
W
Q
S
N
P
A
H
L
Q
A
W
Q
E
G
K
T
G
Y
P
I
V
D
A
A
M
R
Q
L
N
S
T
G
W
M
H
N
R
L
R
M
I
T
A
S
F
L
V
K
D
L
L
I
D
W
R
E
G
E
R
Y
F
M
S
Q
L
I
D
G
D
L
A
A
N
N
G
G
W
Q
W
A
A
S
T
G
T
D
A
A
P
Y
F
R
I
F
N
P
T
T
Q
G
E
K
F
D
H
E
G
E
F
I
R
Q
W
L
P
E
L
R
D
V
P
G
K
-
V
V
H
E
P
W
K
W
A
Q
K
A
G
V
------
T
L
D
Y
P
Q
P
I
V
E
H
K
E
----
A
R
V
Q
T
L
A
A
Y
E
A
A
R
K
------
28
PsiBlast_CBE
89.14
31%
-54
- C4 -
1NP7
2
CRYD_SYNY3
B:
[7-482]
-
T
V
L
V
W
F
R
N
D
L
R
L
H
D
H
E
P
L
H
R
A
-
L
K
S
-
G
L-
A
--
I
T
A
-
V
Y
C
Y
D
P
---
R
--
Q
F
--------
A
-
Q
--
T
H
Q
G
F
A
K
TGPWRSNFLQQ
S
V
Q
N
-----
L
A
E
S
L
--
Q
K
--
V
-
G
N
K
L
L
V
T
T
-
G
L
------
P
E
Q
V
I
P
Q
I
A
K
Q
I
N
A
---
K
T
I
Y
Y
H
R
E
V
T
Q
E
E
L
D
V
E
R
N
L
V
K
Q
L
T
I
L
G
I
E
---
A
K
G
Y
W
G
S
T
L
C
H
P
E
D
L
P
F
S
I
Q
D
L
P
D
L
F
T
----
K
-----
F
R
K
D
I
E
K
--
K
K
I
S
---------
I
RPCFFAPSQ
L
L
P
S
P
N
--
I
K
L
E
--
L
T
----------
A
---
P
P
-
P
E
-----------
F
F
--
P
--
Q
---
I
N
---
F
D
HRS
V
L
A
F
Q
G
---
G
E
T
A
G
L
A
R
L
Q
D
Y
F
W
H
G
DR
L
K
D
Y
K
E
T
R
N
G
M
V
G
A
D
Y
S
S
K
F
S
P
W
L
A
L
G
C
L
S
P
R
-
F
I
Y
Q
---------
E
---
V
KRYE---
Q
E
-------
R
----------
V
S
N
D
S
T
H
--
W
L
I
F
E
L
L
W
R
D
F
-
F
R
F
V
A
Q
K
Y
G
N
-
K
LFN
R
-
G
G
L
L
N
K
N
F
---
P
W
Q
E
D
Q
V
R
F
E
L
W
R
S
G
Q
T
G
Y
P
L
V
D
A
N
M
R
E
L
N
L
T
G
F
M
S
N
R
G
R
Q
N
V
A
S
F
L
C
K
N
L
G
I
D
W
R
W
G
A
E
W
F
E
S
C
L
I
D
Y
D
V
C
S
N
W
G
N
W
N
Y
T
A
G
I
G
N
D
A
R
D
-
F
R
Y
F
N
I
P
K
Q
S
Q
Q
Y
D
P
Q
G
T
Y
L
R
H
W
L
P
E
L
K
N
L
P
G
D
-
K
I
H
Q
P
W
L
L
S
A
T
E
Q
K
Q
W
G
V
Q
L
G
V
D
Y
P
R
P
C
V
N
F
H
Q
SVEA
R
R
K
I
----------------
32
HHSearch
89.12
38%
-47
- C4 -
1DNP
2
PHR_ECOLI
A:
[1-469]
T
T
H
L
V
W
F
R
Q
D
L
R
L
H
D
N
L
A
L
A
A
A
-
C
R
N
S
S
A
-
R
--
V
L
A
-
L
Y
I
A
T
P
---
R
--
Q
W
A
T
---
H
--
N
M
S
P
R
Q
A
E
L
I
N
A
-----------
Q
L
N
G
-----
L
Q
I
A
L
--
A
E
--
K
G
I
-
P
L
L
F
R
E
-
V
D
D
F
V
A
--
S
V
E
I
V
K
Q
V
C
A
E
N
-
S
V
--
T
H
L
F
Y
N
Y
Q
Y
E
V
N
E
R
A
R
D
V
E
V
E
R
A
L
R
--
N
V
V
---
C
E
G
F
D
D
S
V
I
L
P
P
G
A
V
M
T
G
N
H
E
M
Y
K
V
F
T
P
F
K
N
A
-----
W
L
K
R
L
R
E
G
-
M
P
E
C
V
A
-------
A
---------
P
K
V
R
S
S
---
G
S
I
------------------
E
--
P
S
-----------
P
S
--
I
T
L
N
Y
P
R
Q
S
---
F
D
---
T
A
H
F
P
V
---
E
E
K
A
A
I
A
Q
L
R
Q
F
C
Q
N
G
--
A
G
E
Y
E
Q
Q
R
D
-
F
P
A
V
E
G
T
S
R
L
S
A
S
L
A
T
G
G
L
S
P
R
-
Q
C
L
H
---------
R
---
L
-------
L
A
-------
E
QPQA------
L
D
G
G
A
G
S
--
V
W
L
N
E
L
I
W
R
E
F
-
Y
R
H
L
I
T
Y
H
P
S
-
L
---
C
K
H
R
P
F
I
A
W
T
D
R
V
Q
W
Q
S
N
P
A
H
L
Q
A
W
Q
E
G
K
T
G
Y
P
I
V
D
A
A
M
R
Q
L
N
S
T
G
W
M
H
N
R
L
R
M
I
T
A
S
F
L
V
K
D
L
L
I
D
W
R
E
G
E
R
Y
F
M
S
Q
L
I
D
G
D
L
A
A
N
N
G
G
W
Q
W
A
A
S
T
G
T
D
A
A
P
Y
F
R
I
F
N
P
T
T
Q
G
E
K
F
D
H
E
G
E
F
I
R
Q
W
L
P
E
L
R
D
V
P
G
K
-
V
V
H
E
P
W
K
W
A
Q
----
K
A
G
V
T
--
L
D
Y
P
Q
P
I
V
E
H
K
E
----
A
R
V
Q
T
L
A
A
Y
E
A
A
R
K
------
2
PsiBlast_PDB
88.58
35%
-48
- C4 -
1TEZ
5
PHR_SYNP6
A:
[5-461]
---
L
F
W
H
R
R
D
L
R
L
S
D
N
I
G
L
A
A
A
R
A
Q
S
-
A
--
Q
--
L
I
G
-
L
F
C
L
D
P
---
Q
I
L
Q
S
A
D
---
M
--
A
-
P
--
A
R
V
A
Y
L
Q
-----------
G
C
L
Q
E
L
Q
Q
R
Y
Q
Q
A
G
--
S
R
--
L
-
L
-
L
L
Q
----
G
D
------
P
Q
H
L
I
P
Q
L
A
Q
Q
L
Q
A
---
E
A
V
Y
W
N
Q
D
I
E
P
Y
G
R
D
R
D
G
Q
V
A
A
A
L
K
T
A
G
I
R
---
A
V
Q
L
W
D
Q
L
L
H
S
P
D
Q
I
L
S
G
S
G
N
P
Y
S
V
Y
G
P
F
W
K
N
-----
W
Q
A
Q
P
K
P
--
T
P
V
A
---------
T
---------
P
T
E
L
V
D
--
L
S
P
E
--
Q
L
T
A
I
APLLLSE
L
---
P
T
L
K
Q
-----------
L
G
--
F
--
D
---
W
D
---
G
G
---
F
P
V
-
E
P
---
G
E
T
A
A
I
A
R
L
Q
E
F
C
D
R
A
--
I
A
D
Y
D
P
Q
R
N
-
F
P
A
E
A
G
T
S
G
L
S
P
A
L
K
F
G
A
I
G
I
R
-
Q
A
W
Q
---------
A
---
A
S
A
A
H
A
L
S
R
S
-------
D
----------
E
A
R
N
S
I
R
--
V
W
Q
Q
E
L
A
W
R
E
F
-
Y
Q
H
A
L
Y
H
F
P
S
-
L
---
A
-
D
G
P
Y
R
S
L
W
Q
Q
F
P
W
E
N
R
E
A
L
F
T
A
W
T
Q
A
Q
T
G
Y
P
I
V
D
A
A
M
R
Q
L
T
E
T
G
W
M
H
N
R
C
R
M
I
V
A
S
F
L
T
K
D
L
I
I
D
W
R
R
G
E
Q
F
F
M
Q
H
L
V
D
G
D
L
A
A
N
N
G
G
W
Q
W
S
A
S
S
G
M
D
P
K
P
-
L
R
I
F
N
P
A
S
Q
A
K
K
F
D
A
T
A
T
Y
I
K
R
W
L
P
E
L
R
H
V
H
P
K
-
D
L
I
S
G
E
-
I
T
P
I
E
R
--------
R
G
Y
P
A
P
I
V
N
H
N
L
----
R
Q
K
-----------------
9
PsiBlast_PDB
88.39
34%
-43
- C4 -
4U63
17
PHRA_AGRFC
A:
[28-496]
---
I
V
W
F
R
K
D
L
R
L
S
D
N
L
A
L
L
A
A
-
V
E
H
-
G
--
G
--
P
V
I
P
V
Y
I
R
E
K
---
S
--
A
G
P
L
---
G
--
G
-
A
--
Q
E
W
W
L
H
H
-----------
S
L
A
A
-----
L
S
S
S
L
--
E
K
--
A
-
G
G
R
L
V
L
A
S
-
G
D
------
A
E
R
I
L
R
D
L
I
S
E
T
G
A
---
D
T
V
V
W
N
R
R
Y
D
P
T
G
M
A
T
D
K
A
L
K
Q
K
L
R
D
D
G
L
T
---
V
R
S
F
S
G
Q
L
L
H
E
P
S
R
L
Q
T
K
S
G
G
P
Y
R
V
Y
T
P
F
W
R
A
-------
L
E
G
S
D
--
E
P
H
A
---------
P
---------
A
D
P
P
K
S
--
L
T
A
P
--
K
V
----------
W
---
P
K
S
E
K
LSNWKLLPTKP
D
W
--
A
--
K
---
D
F
---
S
D
-----
I
W
T
P
---
G
E
T
G
A
L
D
K
L
D
D
F
I
D
G
A
--
L
K
G
Y
E
E
G
R
D
-
F
P
A
K
P
A
T
S
L
L
S
P
H
L
A
A
G
E
I
S
P
A
-
A
V
W
H
---------
A
T
KG
L
-------
S
R
-------
H
----------
I
A
S
N
D
I
S
--
R
F
R
K
E
I
V
W
R
E
F
-
C
Y
H
L
L
F
H
F
P
E
-
L
---
G
-
E
K
N
W
N
D
S
F
D
A
F
S
W
R
D
D
E
K
S
F
K
A
W
T
R
G
M
T
G
Y
P
I
V
D
A
G
M
R
Q
L
W
Q
H
G
T
M
H
N
R
V
R
M
I
V
A
S
F
L
I
K
H
L
L
I
D
W
R
K
G
E
K
W
F
R
D
T
L
V
D
A
D
P
A
S
N
A
A
N
W
Q
W
V
A
G
S
G
A
D
A
S
P
F
F
R
I
F
N
P
I
L
Q
G
E
K
F
D
G
D
G
D
Y
V
R
R
F
V
P
E
L
E
K
L
E
R
K
-
Y
I
H
K
P
F
E
A
P
K
D
A
L
K
K
A
G
V
E
L
G
K
T
Y
P
L
P
I
V
D
H
G
K
----
A
R
E
R
A
L
A
A
Y
A
A
V
K
K
------
11
PsiBlast_PDB
88.31
31%
-52
- C4 -
1NP7
3
CRYD_SYNY3
A:
[7-482]
-
T
V
L
V
W
F
R
N
D
L
R
L
H
D
H
E
P
L
H
R
A
-
L
K
S
-
G
L
-
A
--
I
T
A
-
V
Y
C
Y
D
P
---
R
--
Q
F
--------
A
-
Q
--
T
H
Q
G
F
A
K
TG
P
W
R
S
N
F
L
Q
Q
S
V
Q
N
-----
L
A
E
S
L
--
Q
K
--
V
-
G
N
K
L
L
V
T
T
-
G
L
------
P
E
Q
V
I
P
Q
I
A
K
Q
I
N
A
---
K
T
I
Y
Y
H
R
E
V
T
Q
E
E
L
D
V
E
R
N
L
V
K
Q
L
T
I
L
G
I
E
---
A
K
G
Y
W
G
S
T
L
C
H
P
E
D
L
P
F
S
I
Q
D
L
P
D
L
F
T
----
K
-----
F
R
K
D
I
E
K
--
K
K
I
S
---------
I
R
P
C
F
F
A
P
S
Q
L
L
P
S
P
N
--
I
K
L
E
--
L
T
----------
A
---
P
P
-
P
E
-----------
F
F
--
P
--
Q
---
I
N
---
F
D
HRS
V
L
A
F
Q
G
---
G
E
T
A
G
L
A
R
L
Q
D
Y
F
W
H
G
DR
L
K
D
Y
K
E
T
R
N
G
M
V
G
A
D
Y
S
S
K
F
S
P
W
L
A
L
G
C
L
S
P
R
-
F
I
Y
Q
---------
E
---
V
K
R
Y
E
---
Q
E
-------
R
----------
V
S
N
D
S
T
H
--
W
L
I
F
E
L
L
W
R
D
F
-
F
R
F
V
A
Q
K
Y
G
N
-
K
LFN
R
-
G
G
L
L
N
K
N
F
---
P
W
Q
E
D
Q
V
R
F
E
L
W
R
S
G
Q
T
G
Y
P
L
V
D
A
N
M
R
E
L
N
L
T
G
F
M
S
N
R
G
R
Q
N
V
A
S
F
L
C
K
N
L
G
I
D
W
R
W
G
A
E
W
F
E
S
C
L
I
D
Y
D
V
C
S
N
W
G
N
W
N
Y
T
A
G
I
G
N
D
A
R
D
-
F
R
Y
F
N
I
P
K
Q
S
Q
Q
Y
D
P
Q
G
T
Y
L
R
H
W
L
P
E
L
K
N
L
P
G
D
-
K
I
H
Q
P
W
L
L
S
A
T
E
Q
K
Q
W
G
V
Q
L
G
V
D
Y
P
R
P
C
V
N
F
H
Q
S
V
E
A
R
R
K
I
----------------
3
PsiBlast_PDB
88.23
35%
-45
- C4 -
1OWL
3
PHR_SYNP6
A:
[6-462]
---
L
F
W
H
R
R
D
L
R
L
S
D
N
I
G
L
A
A
A
R
A
Q
S
-
A
--
Q
--
L
I
G
-
L
F
C
L
D
P
---
Q
I
L
Q
S
A
D
---
M
--
A
-
P
--
A
R
V
A
Y
L
Q
-----------
G
C
L
Q
E
L
Q
Q
R
Y
Q
Q
A
G
--
S
R
--
L
-
L
-
L
L
Q
----
G
D
------
P
Q
H
L
I
P
Q
L
A
Q
Q
L
Q
A
---
E
A
V
Y
W
N
Q
D
I
E
P
Y
G
R
D
R
D
G
Q
V
A
A
A
L
K
T
A
G
I
R
---
A
V
Q
L
W
D
Q
L
L
H
S
P
D
Q
I
L
S
G
S
G
N
P
Y
S
V
Y
G
P
F
W
K
N
-----
W
Q
A
Q
P
K
P
--
T
P
V
A
---------
T
---------
P
T
E
L
V
D
--
L
S
P
E
--
Q
L
T
A
I
APLLLSE
L
---
P
T
L
K
Q
-----------
L
G
--
F
--
D
---
W
D
---
G
G
---
F
P
V
-
E
P
---
G
E
T
A
A
I
A
R
L
Q
E
F
C
D
R
A
--
I
A
D
Y
D
P
Q
R
N
-
F
P
A
E
A
G
T
S
G
L
S
P
A
L
K
F
G
A
I
G
I
R
-
Q
A
W
Q
---------
A
---
A
S
A
A
H
A
L
S
R
S
-------
D
----------
E
A
R
N
S
I
R
--
V
W
Q
Q
E
L
A
W
R
E
F
-
Y
Q
H
A
L
Y
H
F
P
S
-
L
---
A
-
D
G
P
Y
R
S
L
W
Q
Q
F
P
W
E
N
R
E
A
L
F
T
A
W
T
Q
A
Q
T
G
Y
P
I
V
D
A
A
M
R
Q
L
T
E
T
G
W
M
H
N
R
C
R
M
I
V
A
S
F
L
T
K
D
L
I
I
D
W
R
R
G
E
Q
F
F
M
Q
H
L
V
D
G
D
L
A
A
N
N
G
G
W
Q
W
S
A
S
S
G
M
D
P
K
P
-
L
R
I
F
N
P
A
S
Q
A
K
K
F
D
A
T
A
T
Y
I
K
R
W
L
P
E
L
R
H
V
H
P
K
-
D
L
I
S
G
E
-
I
T
P
I
E
R
--------
R
G
Y
P
A
P
I
V
N
H
N
L
----
R
Q
K
-----------------
22
PsiBlast_CBE
87.94
35%
-47
- C4 -
1TEZ
4
PHR_SYNP6
D:
[5-461]
---
L
F
W
H
R
R
D
L
R
L
S
D
N
I
G
L
A
A
A
R
A
Q
S
-
A
--
Q
--
L
I
G
-
L
F
C
L
D
P
---
Q
IL
Q
S
A
D
---
M
--
A
-
P
--
A
R
V
A
Y
L
Q
-----------
G
C
L
Q
ELQQR
Y
Q
Q
A
G
--
S
R
--
L
-
L
-
L
L
Q
----
G
D
------
P
Q
H
L
I
P
Q
L
A
Q
Q
L
Q
A
---
E
A
V
Y
W
N
Q
D
I
E
P
Y
G
R
D
R
D
G
Q
V
A
A
A
L
K
T
A
G
I
R
---
A
V
Q
L
W
D
Q
L
L
H
S
P
D
Q
I
L
S
G
S
G
N
P
Y
S
V
Y
G
P
F
W
K
N
-----
W
Q
A
Q
P
K
P
--
T
P
V
A
---------
T
---------
P
T
E
L
V
D
--
L
S
P
E
--
Q
L
TAIAPLLLSE
L
---
P
T
L
K
Q
-----------
L
G
--
F
--
D
---
W
D
---
G
G
---
F
P
V
-
E
P
---
G
E
T
A
A
I
A
R
L
Q
E
F
C
D
R
A
--
I
A
D
Y
D
P
Q
R
N
-
F
P
A
E
A
G
T
S
G
L
S
P
A
L
K
F
G
A
I
G
I
R
-
Q
A
W
Q
---------
A
---
A
SAAHALS
R
S
-------
D
----------
E
A
R
N
S
I
R
--
V
W
Q
Q
E
L
A
W
R
E
F
-
Y
Q
H
A
L
Y
H
F
P
S
-
L
---
A
-
D
G
P
Y
R
S
L
W
Q
Q
F
P
W
E
N
R
E
A
L
F
T
A
W
T
Q
A
Q
T
G
Y
P
I
V
D
A
A
M
R
Q
L
T
E
T
G
W
M
H
N
R
C
R
M
I
V
A
S
F
L
T
K
D
L
I
I
D
W
R
R
G
E
Q
F
F
M
Q
H
L
V
D
G
D
L
A
A
N
N
G
G
W
Q
W
S
A
S
S
G
M
D
P
K
P
-
L
R
I
F
N
P
A
S
Q
A
K
K
F
D
A
T
A
T
Y
I
K
R
W
L
P
E
L
R
H
V
H
P
K
-
D
L
I
S
G
E
-
I
T
P
I
E
R
--------
R
G
Y
P
A
P
I
V
N
H
N
L
----
R
Q
K
-----------------
23
PsiBlast_CBE
87.88
35%
-46
- C4 -
1TEZ
4
PHR_SYNP6
C:
[5-461]
---
L
F
W
H
R
R
D
L
R
L
S
D
N
I
G
L
A
A
A
R
A
Q
S
-
A
--
Q
--
L
I
G
-
L
F
C
L
D
P
---
Q
IL
Q
S
A
D
---
M
--
A
-
P
--
A
R
V
A
Y
L
Q
-----------
G
C
L
Q
ELQQR
Y
Q
Q
A
G
--
S
R
--
L
-
L
-
L
L
Q
----
G
D
------
P
Q
H
L
I
P
Q
L
A
Q
Q
L
Q
A
---
E
A
V
Y
W
N
Q
D
I
E
P
Y
G
R
D
R
D
G
Q
V
A
A
A
L
K
T
A
G
I
R
---
A
V
Q
L
W
D
Q
L
L
H
S
P
D
Q
I
L
S
G
S
G
N
P
Y
S
V
Y
G
P
F
W
K
N
-----
W
Q
A
Q
P
K
P
--
T
P
V
A
---------
T
---------
P
T
E
L
V
D
--
L
S
P
E
--
Q
L
TAIAPLLLSE
L
---
P
T
L
K
Q
-----------
L
G
--
F
--
D
---
W
D
---
G
G
---
F
P
V
-
E
P
---
G
E
T
A
A
I
A
R
L
Q
E
F
C
D
R
A
--
I
A
D
Y
D
P
Q
R
N
-
F
P
A
E
A
G
T
S
G
L
S
P
A
L
K
F
G
A
I
G
I
R
-
Q
A
W
Q
---------
A
---
A
SAAHALS
R
S
-------
D
----------
E
A
R
N
S
I
R
--
V
W
Q
Q
E
L
A
W
R
E
F
-
Y
Q
H
A
L
Y
H
F
P
S
-
L
---
A
-
D
G
P
Y
R
S
L
W
Q
Q
F
P
W
E
N
R
E
A
L
F
T
A
W
T
Q
A
Q
T
G
Y
P
I
V
D
A
A
M
R
Q
L
T
E
T
G
W
M
H
N
R
C
R
M
I
V
A
S
F
L
T
K
D
L
I
I
D
W
R
R
G
E
Q
F
F
M
Q
H
L
V
D
G
D
L
A
A
N
N
G
G
W
Q
W
S
A
S
S
G
M
D
P
K
P
-
L
R
I
F
N
P
A
S
Q
A
K
K
F
D
A
T
A
T
Y
I
K
R
W
L
P
E
L
R
H
V
H
P
K
-
D
L
I
S
G
E
-
I
T
P
I
E
R
--------
R
G
Y
P
A
P
I
V
N
H
N
L
----
R
Q
K
-----------------
24
PsiBlast_CBE
87.60
35%
-46
- C4 -
1TEZ
5
PHR_SYNP6
B:
[5-461]
---
L
F
W
H
R
R
D
L
R
L
S
D
N
I
G
L
A
A
A
R
A
Q
S
-
A
--
Q
--
L
I
G
-
L
F
C
L
D
P
---
Q
IL
Q
S
A
D
---
M
--
A
-
P
--
A
R
V
A
Y
L
Q
-----------
G
C
L
Q
ELQQR
Y
Q
Q
A
G
--
S
R
--
L
-
L
-
L
L
Q
----
G
D
------
P
Q
H
L
I
P
Q
L
A
Q
Q
L
Q
A
---
E
A
V
Y
W
N
Q
D
I
E
P
Y
G
R
D
R
D
G
Q
V
A
A
A
L
K
T
A
G
I
R
---
A
V
Q
L
W
D
Q
L
L
H
S
P
D
Q
I
L
S
G
S
G
N
P
Y
S
V
Y
G
P
F
W
K
N
-----
W
Q
A
Q
P
K
P
--
T
P
V
A
---------
T
---------
P
T
E
L
V
D
--
L
S
P
E
--
Q
L
TAIAPLLLSE
L
---
P
T
L
K
Q
-----------
L
G
--
F
--
D
---
W
D
---
G
G
---
F
P
V
-
E
P
---
G
E
T
A
A
I
A
R
L
Q
E
F
C
D
R
A
--
I
A
D
Y
D
P
Q
R
N
-
F
P
A
E
A
G
T
S
G
L
S
P
A
L
K
F
G
A
I
G
I
R
-
Q
A
W
Q
---------
A
---
A
SAAHALS
R
S
-------
D
----------
E
A
R
N
S
I
R
--
V
W
Q
Q
E
L
A
W
R
E
F
-
Y
Q
H
A
L
Y
H
F
P
S
-
L
---
A
-
D
G
P
Y
R
S
L
W
Q
Q
F
P
W
E
N
R
E
A
L
F
T
A
W
T
Q
A
Q
T
G
Y
P
I
V
D
A
A
M
R
Q
L
T
E
T
G
W
M
H
N
R
C
R
M
I
V
A
S
F
L
T
K
D
L
I
I
D
W
R
R
G
E
Q
F
F
M
Q
H
L
V
D
G
D
L
A
A
N
N
G
G
W
Q
W
S
A
S
S
G
M
D
P
K
P
-
L
R
I
F
N
P
A
S
Q
A
K
K
F
D
A
T
A
T
Y
I
K
R
W
L
P
E
L
R
H
V
H
P
K
-
D
L
I
S
G
E
-
I
T
P
I
E
R
--------
R
G
Y
P
A
P
I
V
N
H
N
L
----
R
Q
K
-----------------
8
PsiBlast_PDB
87.23
35%
-49
- C4 -
1QNF
2
PHR_SYNP6
A:
[6-462]
---
L
F
W
H
R
R
D
L
R
L
S
D
N
I
G
L
A
A
A
R
A
Q
S
-
A
--
Q
--
L
I
G
-
L
F
C
L
D
P
---
Q
I
L
Q
S
A
D
---
M
--
A
-
P
--
A
R
V
A
Y
L
Q
-----------
G
C
L
Q
E
L
Q
Q
R
Y
Q
Q
A
G
--
S
R
--
L
-
L
-
L
L
Q
----
G
D
------
P
Q
H
L
I
P
Q
L
A
Q
Q
L
Q
A
---
E
A
V
Y
W
N
Q
D
I
E
P
Y
G
R
D
R
D
G
Q
V
A
A
A
L
K
T
A
G
I
R
---
A
V
Q
L
W
D
Q
L
L
H
S
P
D
Q
I
L
S
G
S
G
N
P
Y
S
V
Y
G
P
F
W
K
N
-----
W
Q
A
Q
P
K
P
--
T
P
V
A
---------
T
---------
P
T
E
L
V
D
--
L
S
P
E
--
Q
L
T
A
I
APLLLSE
L
---
P
T
L
K
Q
-----------
L
G
--
F
--
D
---
W
D
---
G
G
---
F
P
V
-
E
P
---
G
E
T
A
A
I
A
R
L
Q
E
F
C
D
R
A
--
I
A
D
Y
D
P
Q
R
N
-
F
P
A
E
A
G
T
S
G
L
S
P
A
L
K
F
G
A
I
G
I
R
-
Q
A
W
Q
---------
A
---
A
S
A
A
H
A
L
S
R
S
-------
D
----------
E
A
R
N
S
I
R
--
V
W
Q
Q
E
L
A
W
R
E
F
-
Y
Q
H
A
L
Y
H
F
P
S
-
L
---
A
-
D
G
P
Y
R
S
L
W
Q
Q
F
P
W
E
N
R
E
A
L
F
T
A
W
T
Q
A
Q
T
G
Y
P
I
V
D
A
A
M
R
Q
L
T
E
T
G
W
M
H
N
R
C
R
M
I
V
A
S
F
L
T
K
D
L
I
I
D
W
R
R
G
E
Q
F
F
M
Q
H
L
V
D
G
D
L
A
A
N
N
G
G
W
Q
W
S
A
S
S
G
M
D
P
K
P
-
L
R
I
F
N
P
A
S
Q
A
K
K
F
D
A
T
A
T
Y
I
K
R
W
L
P
E
L
R
H
V
H
P
K
-
D
L
I
S
G
E
-
I
T
P
I
E
R
--------
R
G
Y
P
A
P
I
V
N
H
N
L
----
R
Q
K
-----------------
4
PsiBlast_PDB
87.19
35%
-46
- C4 -
1OWM
2
PHR_SYNP6
A:
[6-462]
---
L
F
W
H
R
R
D
L
R
L
S
D
N
I
G
L
A
A
A
R
A
Q
S
-
A
--
Q
--
L
I
G
-
L
F
C
L
D
P
---
Q
I
L
Q
S
A
D
---
M
--
A
-
P
--
A
R
V
A
Y
L
Q
-----------
G
C
L
Q
E
L
Q
Q
R
Y
Q
Q
A
G
--
S
R
--
L
-
L
-
L
L
Q
----
G
D
------
P
Q
H
L
I
P
Q
L
A
Q
Q
L
Q
A
---
E
A
V
Y
W
N
Q
D
I
E
P
Y
G
R
D
R
D
G
Q
V
A
A
A
L
K
T
A
G
I
R
---
A
V
Q
L
W
D
Q
L
L
H
S
P
D
Q
I
L
S
G
S
G
N
P
Y
S
V
Y
G
P
F
W
K
N
-----
W
Q
A
Q
P
K
P
--
T
P
V
A
---------
T
---------
P
T
E
L
V
D
--
L
S
P
E
--
Q
L
T
A
I
APLLLSE
L
---
P
T
L
K
Q
-----------
L
G
--
F
--
D
---
W
D
---
G
G
---
F
P
V
-
E
P
---
G
E
T
A
A
I
A
R
L
Q
E
F
C
D
R
A
--
I
A
D
Y
D
P
Q
R
N
-
F
P
A
E
A
G
T
S
G
L
S
P
A
L
K
F
G
A
I
G
I
R
-
Q
A
W
Q
---------
A
---
A
S
A
A
H
A
L
S
R
S
-------
D
----------
E
A
R
N
S
I
R
--
V
W
Q
Q
E
L
A
W
R
E
F
-
Y
Q
H
A
L
Y
H
F
P
S
-
L
---
A
-
D
G
P
Y
R
S
L
W
Q
Q
F
P
W
E
N
R
E
A
L
F
T
A
W
T
Q
A
Q
T
G
Y
P
I
V
D
A
A
M
R
Q
L
T
E
T
G
W
M
H
N
R
C
R
M
I
V
A
S
F
L
T
K
D
L
I
I
D
W
R
R
G
E
Q
F
F
M
Q
H
L
V
D
G
D
L
A
A
N
N
G
G
W
Q
W
S
A
S
S
G
M
D
P
K
P
-
L
R
I
F
N
P
A
S
Q
A
K
K
F
D
A
T
A
T
Y
I
K
R
W
L
P
E
L
R
H
V
H
P
K
-
D
L
I
S
G
E
-
I
T
P
I
E
R
--------
R
G
Y
P
A
P
I
V
N
H
N
L
----
R
Q
K
-----------------
5
PsiBlast_PDB
87.14
35%
-47
- C4 -
1OWN
2
PHR_SYNP6
A:
[6-462]
---
L
F
W
H
R
R
D
L
R
L
S
D
N
I
G
L
A
A
A
R
A
Q
S
-
A
--
Q
--
L
I
G
-
L
F
C
L
D
P
---
Q
I
L
Q
S
A
D
---
M
--
A
-
P
--
A
R
V
A
Y
L
Q
-----------
G
C
L
Q
E
L
Q
Q
R
Y
Q
Q
A
G
--
S
R
--
L
-
L
-
L
L
Q
----
G
D
------
P
Q
H
L
I
P
Q
L
A
Q
Q
L
Q
A
---
E
A
V
Y
W
N
Q
D
I
E
P
Y
G
R
D
R
D
G
Q
V
A
A
A
L
K
T
A
G
I
R
---
A
V
Q
L
W
D
Q
L
L
H
S
P
D
Q
I
L
S
G
S
G
N
P
Y
S
V
Y
G
P
F
W
K
N
-----
W
Q
A
Q
P
K
P
--
T
P
V
A
---------
T
---------
P
T
E
L
V
D
--
L
S
P
E
--
Q
L
T
A
I
APLLLSE
L
---
P
T
L
K
Q
-----------
L
G
--
F
--
D
---
W
D
---
G
G
---
F
P
V
-
E
P
---
G
E
T
A
A
I
A
R
L
Q
E
F
C
D
R
A
--
I
A
D
Y
D
P
Q
R
N
-
F
P
A
E
A
G
T
S
G
L
S
P
A
L
K
F
G
A
I
G
I
R
-
Q
A
W
Q
---------
A
---
A
S
A
A
H
A
L
S
R
S
-------
D
----------
E
A
R
N
S
I
R
--
V
W
Q
Q
E
L
A
W
R
E
F
-
Y
Q
H
A
L
Y
H
F
P
S
-
L
---
A
-
D
G
P
Y
R
S
L
W
Q
Q
F
P
W
E
N
R
E
A
L
F
T
A
W
T
Q
A
Q
T
G
Y
P
I
V
D
A
A
M
R
Q
L
T
E
T
G
W
M
H
N
R
C
R
M
I
V
A
S
F
L
T
K
D
L
I
I
D
W
R
R
G
E
Q
F
F
M
Q
H
L
V
D
G
D
L
A
A
N
N
G
G
W
Q
W
S
A
S
S
G
M
D
P
K
P
-
L
R
I
F
N
P
A
S
Q
A
K
K
F
D
A
T
A
T
Y
I
K
R
W
L
P
E
L
R
H
V
H
P
K
-
D
L
I
S
G
E
-
I
T
P
I
E
R
--------
R
G
Y
P
A
P
I
V
N
H
N
L
----
R
Q
K
-----------------
7
PsiBlast_PDB
86.97
35%
-45
- C4 -
1OWP
2
PHR_SYNP6
A:
[6-462]
---
L
F
W
H
R
R
D
L
R
L
S
D
N
I
G
L
A
A
A
R
A
Q
S
-
A
--
Q
--
L
I
G
-
L
F
C
L
D
P
---
Q
I
L
Q
S
A
D
---
M
--
A
-
P
--
A
R
V
A
Y
L
Q
-----------
G
C
L
Q
E
L
Q
Q
R
Y
Q
Q
A
G
--
S
R
--
L
-
L
-
L
L
Q
----
G
D
------
P
Q
H
L
I
P
Q
L
A
Q
Q
L
Q
A
---
E
A
V
Y
W
N
Q
D
I
E
P
Y
G
R
D
R
D
G
Q
V
A
A
A
L
K
T
A
G
I
R
---
A
V
Q
L
W
D
Q
L
L
H
S
P
D
Q
I
L
S
G
S
G
N
P
Y
S
V
Y
G
P
F
W
K
N
-----
W
Q
A
Q
P
K
P
--
T
P
V
A
---------
T
---------
P
T
E
L
V
D
--
L
S
P
E
--
Q
L
T
A
I
APLLLS
E
L
---
P
T
L
K
Q
-----------
L
G
--
F
--
D
---
W
D
---
G
G
---
F
P
V
-
E
P
---
G
E
T
A
A
I
A
R
L
Q
E
F
C
D
R
A
--
I
A
D
Y
D
P
Q
R
N
-
F
P
A
E
A
G
T
S
G
L
S
P
A
L
K
F
G
A
I
G
I
R
-
Q
A
W
Q
---------
A
---
A
S
A
A
H
A
L
S
R
S
-------
D
----------
E
A
R
N
S
I
R
--
V
W
Q
Q
E
L
A
W
R
E
F
-
Y
Q
H
A
L
Y
H
F
P
S
-
L
---
A
-
D
G
P
Y
R
S
L
W
Q
Q
F
P
W
E
N
R
E
A
L
F
T
A
W
T
Q
A
Q
T
G
Y
P
I
V
D
A
A
M
R
Q
L
T
E
T
G
W
M
H
N
R
C
R
M
I
V
A
S
F
L
T
K
D
L
I
I
D
W
R
R
G
E
Q
F
F
M
Q
H
L
V
D
G
D
L
A
A
N
N
G
G
W
Q
W
S
A
S
S
G
M
D
P
K
P
-
L
R
I
F
N
P
A
S
Q
A
K
K
F
D
A
T
A
T
Y
I
K
R
W
L
P
E
L
R
H
V
H
P
K
-
D
L
I
S
G
E
-
I
T
P
I
E
R
--------
R
G
Y
P
A
P
I
V
N
H
N
L
----
R
Q
K
-----------------
6
PsiBlast_PDB
86.73
35%
-44
- C4 -
1OWO
2
PHR_SYNP6
A:
[6-462]
---
L
F
W
H
R
R
D
L
R
L
S
D
N
I
G
L
A
A
A
R
A
Q
S
-
A
--
Q
--
L
I
G
-
L
F
C
L
D
P
---
Q
I
L
Q
S
A
D
---
M
--
A
-
P
--
A
R
V
A
Y
L
Q
-----------
G
C
L
Q
E
L
Q
Q
R
Y
Q
Q
A
G
--
S
R
--
L
-
L
-
L
L
Q
----
G
D
------
P
Q
H
L
I
P
Q
L
A
Q
Q
L
Q
A
---
E
A
V
Y
W
N
Q
D
I
E
P
Y
G
R
D
R
D
G
Q
V
A
A
A
L
K
T
A
G
I
R
---
A
V
Q
L
W
D
Q
L
L
H
S
P
D
Q
I
L
S
G
S
G
N
P
Y
S
V
Y
G
P
F
W
K
N
-----
W
Q
A
Q
P
K
P
--
T
P
V
A
---------
T
---------
P
T
E
L
V
D
--
L
S
P
E
--
Q
L
T
A
I
APLLLS
E
L
---
P
T
L
K
Q
-----------
L
G
--
F
--
D
---
W
D
---
G
G
---
F
P
V
-
E
P
---
G
E
T
A
A
I
A
R
L
Q
E
F
C
D
R
A
--
I
A
D
Y
D
P
Q
R
N
-
F
P
A
E
A
G
T
S
G
L
S
P
A
L
K
F
G
A
I
G
I
R
-
Q
A
W
Q
---------
A
---
A
S
A
A
H
A
L
S
R
S
-------
D
----------
E
A
R
N
S
I
R
--
V
W
Q
Q
E
L
A
W
R
E
F
-
Y
Q
H
A
L
Y
H
F
P
S
-
L
---
A
-
D
G
P
Y
R
S
L
W
Q
Q
F
P
W
E
N
R
E
A
L
F
T
A
W
T
Q
A
Q
T
G
Y
P
I
V
D
A
A
M
R
Q
L
T
E
T
G
W
M
H
N
R
C
R
M
I
V
A
S
F
L
T
K
D
L
I
I
D
W
R
R
G
E
Q
F
F
M
Q
H
L
V
D
G
D
L
A
A
N
N
G
G
W
Q
W
S
A
S
S
G
M
D
P
K
P
-
L
R
I
F
N
P
A
S
Q
A
K
K
F
D
A
T
A
T
Y
I
K
R
W
L
P
E
L
R
H
V
H
P
K
-
D
L
I
S
G
E
-
I
T
P
I
E
R
--------
R
G
Y
P
A
P
I
V
N
H
N
L
----
R
Q
K
-----------------
29
HHSearch
86.43
29%
-48
* C4 *
1U3D
7
CRY1_ARATH
A:
[13-496]
-
C
S
I
V
W
F
R
R
D
L
R
V
E
D
N
P
A
L
A
A
A
-
V
R
A
-
G
--
P
--
V
I
A
-
L
F
V
W
A
P
---
E
--
E
E
G
H
---
Y
--
H
P
G
R
V
S
R
W
W
L
K
N
-----------
S
L
A
Q
-----
L
D
S
S
L
--
R
S
--
L
G
T
-
C
L
I
T
K
R
S
T
D
------
S
V
A
S
L
L
D
V
V
K
S
T
-
G
A
--
S
Q
I
F
F
N
H
L
Y
D
P
L
S
L
V
R
D
H
R
A
K
D
V
L
T
A
Q
G
I
A
---
V
R
S
F
N
A
D
L
L
Y
E
P
W
E
V
T
D
E
L
G
R
P
F
S
M
F
A
A
F
W
E
R
-----
C
L
S
M
P
Y
D
PE
S
P
L
L
---------
P
---------
P
K
K
I
I
S
G
D
V
S
K
C
--
V
-----------
A
---
D
P
L
V
F
-----------
E
D
D
S
E
K
G
S
---
N
A
---
L
L
---
A
R
A
W
S
P
---
G
W
S
N
G
D
K
A
L
T
T
F
I
N
G
P
--
L
L
E
Y
S
K
N
R
R
-
K
A
D
S
A
T
T
S
F
L
S
P
H
L
H
F
G
E
V
S
V
R
-
K
V
F
H
---------
L
---
V
-------
R
I
-------
K
Q
V
A
W
A
N
E
GN
E
A
G
E
E
S
V
N
--
L
F
L
K
S
I
G
L
R
E
Y
-
S
R
Y
I
S
F
N
H
P
Y
-
S
---
H
-
E
R
P
L
L
G
H
L
K
F
F
P
W
A
V
D
E
N
Y
F
K
A
W
R
Q
G
R
T
G
Y
P
L
V
D
A
G
M
R
E
L
W
A
T
G
W
L
H
D
R
I
R
V
V
V
S
S
F
F
V
K
V
L
Q
L
P
W
R
W
G
M
K
Y
F
W
D
T
L
L
D
A
D
L
E
S
D
A
L
G
W
Q
Y
I
T
G
T
L
P
D
S
R
E
F
D
R
I
D
N
P
Q
F
E
G
Y
K
F
D
P
N
G
E
Y
V
R
R
W
L
P
E
L
S
R
L
P
T
D
-
W
I
H
H
P
W
N
A
P
E
S
V
L
Q
A
A
G
I
E
L
G
S
N
Y
P
L
P
I
V
G
L
D
E
----
A
K
A
R
L
H
E
A
L
S
Q
M
W
Q
L
E
A
---
12
PsiBlast_PDB
85.99
30%
-41
- C4 -
1U3C
7
CRY1_ARATH
A:
[15-481]
---
I
V
W
F
R
R
D
L
R
V
E
D
N
P
A
L
A
A
A
-
V
R
A
-
G
--
P
--
V
I
A
-
L
F
V
W
A
P
EEE
G
--
H
Y
H
P
---
G
--
R
-
V
--
S
R
W
W
L
K
N
-----------
S
L
A
Q
-----
L
D
S
S
L
--
R
S
L
G
T
-
C
-
L
I
T
K
R
S
-
T
D
------
S
V
A
S
L
L
D
V
V
K
S
T
G
A
---
S
Q
I
F
F
N
H
L
Y
D
P
L
S
L
V
R
D
H
R
A
K
D
V
L
T
A
Q
G
I
A
---
V
R
S
F
N
A
D
L
L
Y
E
P
W
E
V
T
D
E
L
G
R
P
F
S
M
F
A
A
F
W
E
R
C
L
S
MP
Y
D
P
E
S
P
L
--
L
P
P
K
---------
K
---------
I
I
S
G
D
---
V
S
K
C
--
V
A
----------
D
---
P
L
V
F
E
-----------
D
D
--
S
--
E
---
K
G
---
S
N
---
A
L
L
A
R
A
W
S
P
G
W
S
N
G
D
K
A
L
T
T
F
I
N
G
P
--
L
L
E
Y
S
K
N
R
R
-
K
A
D
S
A
T
T
S
F
L
S
P
H
L
H
F
G
E
V
S
V
R
-
K
V
F
H
L
V
R
I
K
Q
V
A
W
A
---
N
-------
E
G
-------
N
----------
E
A
G
E
E
S
V
N
-
L
F
L
K
S
I
G
L
R
E
Y
-
S
R
Y
I
S
F
N
H
P
Y
-
S
---
H
-
E
R
P
L
L
G
H
L
K
F
F
P
W
A
V
D
E
N
Y
F
K
A
W
R
Q
G
R
T
G
Y
P
L
V
D
A
G
M
R
E
L
W
A
T
G
W
L
H
D
R
I
R
V
V
V
S
S
F
F
V
K
V
L
Q
L
P
W
R
W
G
M
K
Y
F
W
D
T
L
L
D
A
D
L
E
S
D
A
L
G
W
Q
Y
I
T
G
T
L
P
D
S
R
E
F
D
R
I
D
N
P
Q
F
E
G
Y
K
F
D
P
N
G
E
Y
V
R
R
W
L
P
E
L
S
R
L
P
T
D
-
W
I
H
H
P
W
N
A
P
E
S
V
L
Q
A
A
G
I
E
L
G
S
N
Y
P
L
P
I
V
G
L
D
E
----
A
K
------------------
15
PsiBlast_PDB
75.77
31%
-36
- C4 -
1IQU
3
PHR_THET8
A:
[5-390]
---
L
V
W
H
R
G
D
L
R
L
H
D
H
P
A
L
L
E
A
-
L
A
R
-
G
--
P
--
V
V
G
-
L
V
V
L
D
P
---
N
--
N
L
K
T
------
T
-
P
--
R
R
R
A
W
F
L
-----------
E
N
V
R
-----
A
L
R
E
A
Y
R
A
R
--
G
-
G
-
A
L
W
V
L
E
-
G
L
------
P
W
E
K
V
P
E
A
A
R
R
L
K
A
---
K
A
V
Y
A
L
T
S
H
T
P
Y
G
R
Y
R
D
G
R
V
R
--------
E
---
A
L
P
V
P
L
H
L
L
P
A
P
H
L
L
P
P
D
L
P
R
A
Y
R
V
Y
T
P
F
S
R
L
-----
Y
R
G
A
A
P
P
--
L
P
P
P
---------
E
---------
A
L
P
K
G
P
----
E
E
--
G
E
----------
I
---
P
R
E
D
P
----------------------------
G
---
L
P
L
P
E
P
---
G
E
E
A
A
L
A
G
L
R
A
F
L
E
A
K
--
L
P
R
Y
A
E
E
R
D
-
R
L
D
G
E
G
G
S
R
L
S
P
Y
F
A
L
G
V
L
S
P
R
L
A
A
W
E
---------
A
------------
E
-------
R
----------
R
G
G
E
G
A
R
--
K
W
V
A
E
L
L
W
R
D
F
S
Y
H
L
L
Y
-
H
F
P
W
-
M
---
A
-
E
R
P
L
D
P
R
F
Q
A
F
P
W
Q
E
D
E
A
L
F
Q
A
W
Y
E
G
K
T
G
V
P
L
V
D
A
A
M
R
E
L
H
A
T
G
F
L
S
N
R
A
R
M
N
A
A
Q
F
A
V
K
H
L
L
L
P
W
K
R
C
E
E
A
F
R
H
L
L
L
D
G
D
R
A
V
N
L
Q
G
W
Q
W
A
G
G
L
G
V
D
A
A
P
Y
F
R
V
F
N
P
V
L
Q
G
E
R
H
D
P
E
G
R
W
L
K
R
W
A
P
E
-----------------------------------------------------------------