@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1505: (2016-03-25 )
MTKVLTFENISYWYKTKDESILNDINYDFEAGVFYTVVGSSGSGKTTFLSLAGGLDTQKEGDIYYKGSSLKSIGLQQFRNKYVSIVFQSYNLLTYMTALQNVTTAMEITHVNQPDKKAFALSMLEKVGITEEMARQKVLTLSGGQQQRVSIARALCCETELIVADEPTGNLDERTSKEVVTLFQDLAHKEGKCVIMVTHDPEIAKVSDVKLTLKNGSFVEKKQSMNSLINS
Atome Classification :
(35 SA)
.........10......--..20--........30........40........50........60....---....----------70.--.--.---....---.--80........90.........100...-....110-.---.......-.120--.......130.......140.......150.......160.......170.......180.......190.......200...-....210.......220.......230
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
K
V
L
T
FEN
I
S
Y
W
Y
KTK--
D
E
S
I
--
L
N
DINYDFEA
G
V
F
Y
T
V
VGSSGSG
K
T
T
F
L
S
LAGGLDTQKEG
D
I
Y
Y
---KGS
S
----------
L
K
S
--
I
--
G
---
L
Q
Q
F
---
R
--
N
K
Y
V
S
I
V
F
Q
S
Y
-
N
L
L
T
Y
M
T
A
L
Q
N
V
T
T
A
-
M
E
I
T
H---V---NQP
D
K
K
A
-
F
A
L
S
--
M
L
E
KVG
I
T
E
E
M
A
R
Q
K
V
L
TLSGG
Q
Q
Q
R
V
S
I
A
R
A
L
CCE
T
E
L
I
V
ADEPTGNLD
E
R
T
S
K
E
V
V
T
L
F
Q
D
L
A
HKEG
K
C
V
I
M
V
THDPEI
A
K
-
V
S
D
V
K
L
T
LKNG
S
F
V
E
K
K
Q
S
M
N
S
L
INS
1
PsiBlast_PDB
89.25
35%
-99
- C1 -
1L2T
4
Y796_METJA
A:
[1-229]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
--
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
DNI
K
T
N
D
----------
L
D
D
--
D
--
E
---
L
T
K
I
---
R
--
R
D
K
I
G
F
V
F
Q
Q
F
-
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
R
G
A
M
---
S
G
E
E
R
R
K
-
R
A
L
E
--
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
-
V
E
R
E
E
K
L
------
22
PsiBlast_CBE
88.67
34%
-102
- C1 -
3TIF
7
Y796_METJA
B:
[1-229]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
--
E
E
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
DNI
K
T
N
D
----------
L
D
D
--
D
--
E
---
L
T
K
I
---
R
--
R
D
K
I
G
F
V
F
Q
Q
F
-
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
RGA
M
---
S
G
E
E
R
R
K
-
R
A
L
E
--
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
-
V
E
R
E
E
K
L
------
41
PsiBlast_CBE
88.39
37%
-107
- C1 -
1B0U
4
HISP_SALTY
A:
[21-234]
----------------------
V
--
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
---
N
G
Q
N
I
N
L
V
R
D
KDGQ
L
K
V
--
A
--
D
---
K
N
Q
L
---
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
-
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
---
L
---
S
K
H
D
A
R
E
-
R
A
L
K
--
Y
L
A
K
V
G
I
D
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
-
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
----------
21
PsiBlast_CBE
88.30
35%
-98
- C1 -
1L2T
4
Y796_METJA
B:
[1-229]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
--
E
E
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
DNI
K
T
N
D
----------
L
D
D
--
D
--
E
---
L
T
K
I
---
R
--
R
D
K
I
G
F
V
F
Q
Q
F
-
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
RGA
M
---
S
G
E
E
R
R
K
-
R
A
L
E
--
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
-
V
E
R
E
E
K
L
------
3
PsiBlast_PDB
87.93
34%
-100
- C1 -
3TIF
7
Y796_METJA
A:
[1-229]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
--
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
DNI
K
T
N
D
----------
L
D
D
--
D
--
E
---
L
T
K
I
---
R
--
R
D
K
I
G
F
V
F
Q
Q
F
-
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
R
G
A
M
---
S
G
E
E
R
R
K
-
R
A
L
E
--
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
-
V
E
R
E
E
K
L
------
2
PsiBlast_PDB
87.72
35%
-97
- C1 -
1F3O
2
Y796_METJA
A:
[2-229]
----
I
K
L
K
N
V
T
K
T
Y
K
M
G
--
E
E
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
DNI
K
T
N
D
----------
L
D
D
--
D
--
E
---
L
T
K
I
---
R
--
R
D
K
I
G
F
V
F
Q
Q
F
-
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
RGA
M
---
S
G
E
E
R
R
K
-
R
A
L
E
--
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
-
V
E
R
E
E
K
L
------
96
HHSearch
84.78
36%
-97
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[2-221]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
----
G
Y
E
I
--
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
---
E
G
K
E
----------
V
D
Y
--
T
--
N
---
E
K
E
L
S
L
L
R
--
N
R
K
L
G
F
V
F
Q
F
H
-
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
-
M
L
K
M
G
---
K
---
P
K
K
E
A
K
E
-
R
G
E
Y
--
L
L
S
E
L
G
L
G
D
K
L
-
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
S
I
V
M
V
T
H
E
R
E
L
A
E
-
L
T
H
R
T
L
E
M
K
D
G
K
V
V
G
E
I
---------
5
PsiBlast_PDB
84.34
36%
-110
- C1 -
2PCL
12
LOLD_AQUAE
A:
[2-218]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
G
Y
--
E
--
I
--
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
---
E
G
K
E
----------
V
D
Y
--
T
--
N
E
K
E
L
S
L
L
---
R
--
N
R
K
L
G
F
V
F
Q
F
H
-
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
-
M
--
L
K
---
M
---
G
K
P
K
K
E
A
-
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
K
L
S
R
-
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
-
N
E
G
G
T
S
I
V
M
V
T
H
E
R
E
L
A
E
-
L
T
H
R
T
L
E
M
K
D
G
K
V
V
------------
23
PsiBlast_CBE
83.47
36%
-109
- C1 -
2PCJ
1
LOLD_AQUAE
B:
[2-218]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
G
Y
--
E
--
I
--
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
---
E
G
K
E
----------
V
D
Y
--
T
--
N
EKE
L
S
L
L
---
R
--
N
R
K
L
G
F
V
F
Q
F
H
-
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
-
M
--
L
K
---
M
---
G
K
P
K
K
E
A
-
K
E
R
G
EY
L
L
S
E
L
G
L
G
D
K
L
S
R
-
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
-
N
E
G
G
T
S
I
V
M
V
T
H
E
R
E
L
A
E
-
L
T
H
R
T
L
E
M
K
D
G
K
V
V
------------
4
PsiBlast_PDB
82.66
36%
-106
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[2-218]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
G
Y
--
E
--
I
--
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
---
E
G
K
E
----------
V
D
Y
--
T
--
N
E
K
E
L
S
L
L
---
R
--
N
R
K
L
G
F
V
F
Q
F
H
-
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
-
M
--
L
K
---
M
---
G
K
P
K
K
E
A
-
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
K
L
S
R
-
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
-
N
E
G
G
T
S
I
V
M
V
T
H
E
R
E
L
A
E
-
L
T
H
R
T
L
E
M
K
D
G
K
V
V
------------
10
PsiBlast_PDB
82.29
38%
-103
- C1 -
2OUK
1
?
A:
[39-240]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
KD
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
26
PsiBlast_CBE
82.24
35%
-92
- C1 -
4U02
1
?
B:
[1-222]
M
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
----
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
---
D
G
L
S
----------
V
K
D
D-
R
--
A
---
L
R
E
I
---
R
--
R
E
-
V
G
M
V
F
Q
Q
F
-
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
---
W
---
P
R
E
K
A
E
K
-
K
A
L
E
--
L
L
E
R
V
G
I
L
D
Q
-
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
-------
25
PsiBlast_CBE
82.10
35%
-95
- C1 -
4U02
1
?
C:
[1-222]
M
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
----
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
---
D
G
L
S
----------
V
K
D
D-
R
--
A
---
L
R
E
I
---
R
--
R
E
-
V
G
M
V
F
Q
Q
F
-
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
---
W
---
P
R
E
K
A
E
K
-
K
A
L
E
--
L
L
E
R
V
G
I
L
D
Q
-
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
-------
8
PsiBlast_PDB
81.89
38%
-101
- C1 -
2OLJ
4
?
A:
[39-240]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
KD
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
32
PsiBlast_CBE
81.62
38%
-100
- C1 -
2OLK
1
?
D:
[39-240]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
KD
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
99
HHSearch
81.44
33%
-92
- C1 -
3TIF
7
Y796_METJA
A:
[2-230]
----
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
--
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
---
D
N
I
K
----------
T
N
D
--
L
--
D
---
D
D
E
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
Q
F
-
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
---
R
G
A
M
S
G
E
E
R
R
K
-
R
A
L
E
--
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
------
98
HHSearch
80.94
35%
-97
- C1 -
2OLJ
4
?
A:
[22-247]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
--
K
DT
N
---
L
N
K
V
------
R
E
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
M
K
V
R
K--
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
-
E
D
L
F
--
6
PsiBlast_PDB
80.71
35%
-95
- C1 -
4U00
3
?
A:
[3-222]
--
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
----
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
---
D
G
L
S
----------
V
K
D
D-
R
--
A
---
L
R
E
I
---
R
--
R
E
-
V
G
M
V
F
Q
Q
F
-
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
---
W
---
P
R
E
K
A
E
K
-
K
A
L
E
--
L
L
E
R
V
G
I
L
D
Q
-
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
-------
27
PsiBlast_CBE
80.70
38%
-98
- C1 -
3C4J
4
?
B:
[39-240]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
KD
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
12
PsiBlast_PDB
80.63
38%
-98
- C1 -
3C4J
3
?
A:
[39-240]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
KD
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
34
PsiBlast_CBE
80.41
38%
-96
- C1 -
2OLK
2
?
B:
[39-240]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
KD
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
39
PsiBlast_CBE
80.22
33%
-113
- C1 -
4HLU
2
ECFA1_THEMA
D:
[19-216]
-------------
F
R
Y
N
--
G
D
Y
V
--
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
-
L
A
A
A
G
E
I
F
L
---
D
G
S
P
----------
A
D
P
--
F
--
L
---
L
R
---------
K
N
V
G
Y
V
F
Q
N
P
S
S
Q
I
I
G
A
T
V
E
E
D
V
A
F
S
-
L
E
I
M
G
---
L
---
D
E
S
E
M
R
K
-
R
I
K
K
--
V
L
E
L
V
G
L
S
-
G
L
A
A
A
D
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
K
N
-
E
G
K
G
I
I
L
V
T
H
E
L
E
Y
L
D
-
D
M
D
F
I
L
H
I
S
N
G
T
--------------
40
PsiBlast_CBE
79.67
33%
-113
- C1 -
4HLU
3
ECFA1_THEMA
C:
[19-216]
-------------
F
R
Y
N
--
G
D
Y
V
--
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
-
L
A
A
A
G
E
I
F
L
---
D
G
S
P
----------
A
D
P
--
F
--
L
---
L
R
---------
K
N
V
G
Y
V
F
Q
N
P
S
S
Q
I
I
G
A
T
V
E
E
D
V
A
F
S
-
L
E
I
M
G
---
L
---
D
E
S
E
M
R
K
-
R
I
K
K
--
V
L
E
L
V
G
L
S
-
G
L
A
A
A
D
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
K
N
-
E
G
K
G
I
I
L
V
T
H
E
L
E
Y
L
D
-
D
M
D
F
I
L
H
I
S
N
G
T
--------------
36
PsiBlast_CBE
79.50
38%
-96
- C1 -
3C41
3
?
K:
[18-219]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
KD
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
11
PsiBlast_PDB
79.13
38%
-95
- C1 -
2Q0H
4
?
A:
[39-240]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
KD
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
17
PsiBlast_PDB
79.00
33%
-100
- C1 -
4YMV
1
?
J:
[16-217]
----------------------
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
---
D
G
V
K
----------
I
N
N
GK
V
--
N
---
I
N
K
V
---
R
--
Q
K
-
V
G
M
V
F
Q
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
---
M
---
N
K
K
E
A
E
E
-
L
A
V
D
--
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
----------
33
PsiBlast_CBE
78.83
38%
-93
- C1 -
2OLK
1
?
C:
[39-240]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
KD
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
9
PsiBlast_PDB
78.71
38%
-95
- C1 -
2OLK
1
?
A:
[39-240]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
K
D
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
38
PsiBlast_CBE
78.68
33%
-101
- C1 -
4YMU
2
?
A:
[16-217]
----------------------
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
---
D
G
V
K
----------
I
N
N
GK
V
--
N
---
I
N
K
V
---
R
--
Q
K
-
V
G
M
V
F
Q
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
---
M
---
N
K
K
E
A
E
E
-
L
A
V
D
--
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
----------
16
PsiBlast_PDB
78.43
33%
-102
- C1 -
4YMU
2
?
J:
[16-217]
----------------------
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
---
D
G
V
K
----------
I
N
N
GK
V
--
N
---
I
N
K
V
---
R
--
Q
K
-
V
G
M
V
F
Q
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
---
M
---
N
K
K
E
A
E
E
-
L
A
V
D
--
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
----------
37
PsiBlast_CBE
77.66
33%
-99
- C1 -
4YMV
1
?
A:
[16-217]
----------------------
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
---
D
G
V
K
----------
I
N
N
GK
V
--
N
---
I
N
K
V
---
R
--
Q
K
-
V
G
M
V
F
Q
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
---
M
---
N
K
K
E
A
E
E
-
L
A
V
D
--
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
----------
35
PsiBlast_CBE
77.58
38%
-93
- C1 -
2OLJ
3
?
B:
[39-240]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
KD
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
28
PsiBlast_CBE
77.54
38%
-92
- C1 -
2Q0H
4
?
B:
[39-240]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
KD
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
13
PsiBlast_PDB
77.49
38%
-90
- C1 -
3C41
3
?
J:
[18-219]
----------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
----------
L
K
A
KD
T
--
N
---
L
N
K
V
---
R
--
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
---
W
---
P
R
E
K
A
E
A
-
K
A
M
E
--
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
----------
44
PsiBlast_CBE
55.55
32%
-106
- C1 -
1VCI
1
?
A:
[28-208]
-------------------------
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
---
G
D
R
D
----------
V
T
Y
--
L
--------
P
P
---
K
--
D
R
N
I
S
M
V
F
Q
-------
H
M
T
V
Y
E
N
I
A
F
P
-
L
--
K
K
---
F
P
K
-
D
E
I
D
K
R
V
R
W
A
A
E
--
L
L
Q
----
I
E
E
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
--------------------------------