@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2360: (2016-04-03 )
MDMVKNEWKKLFKNKILLLSFVVILFIPLLYASFFLKSVWDPYGKTGDLPVAVVNNDKPVDYNGQTMDVGDQLVTKLKSNKELDWNFLSKEEAEQGLKDGKYYMIVTIPKDFSKNAASVLDKDPKKMELSYKTNGSLNYLGQVVSEQGAKQLKSEVSAEVTKSYAEAIFDKIKESGDGFAQAADGSGKIKDGLVKSQEGNKTISTNLKTLADSSLTFKDGANTLEVGLKTYTDGVNTAAAGGDKLNAGVSTLAAGVGPLKDGVAALDGGATKLASGVSTYTSGVDTLAGGINQAYTGSTALSDGLNKMNGSVPTLASGITQLNNGQKSLATGLDSLVDGSNKLSAGLKELDGNLTDKQGKIAQLKQGMNDLQQGIDQLNQSVNGEDAALAKQLATLQKSLSDLQNGLTFIKSNANFDAEAIKSKINATAGVSAEDKQKIIDAIQADLDKETQKSATQVATVEQLQSGLSGLDLAAIQTQVTELQTGVAKISAGYQAVHGGTNEAFNSIHQAINGSGSQTLLGGANQLTAGLKSAQAGSAKLVAGTNQLNSQVPTLTSGVGQLAAGSASMENGLSKLNDGGNKLASNSGALRSGATELQGGTNQLAAKVPTLAGGVNQLQAGSNQLAGGLNQLSANSPKLVSGVGQLADGSSKIADGSSKLANGSFQLGDGLTKLTDGSTELTDKLADGAQQVKDTKATDKTFNMIAAPTKLAHNEYTHVSNYGHALAPYVLSLALYVGALVFNFIMPIRRVSMEGQPAYKWWLSKLSLGFVAAVAMALLEGGIMIALGLRPDSIVEFFGTAIITALAYMFLIMLLAMTFDNPGRFIAMVLLIVQLAGSGGTFPMPLTGWFFNLIHPFLPMTYSIYAFRESLAAGMGPNVYSMSMLILTIIMVACVGLLYLSMSHLKKRHDAHESALDDNQKLMALEN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80.....--....90........100.......110..-.....----120.......130..---.....140.......150.....-..160----------..------.....170.......--180..---.....190...--.....200.......210------------.......220.......230.......240.......250....---...260.......270...-.---...-280.--......290.......300..-.....310.......320.......330......--.340----.........350.......360........-----.370.......380.....---..390..------..----------...400.......-.-.410.......--------420.----......430.......440.......450......------.460.------------......470..-----.....480--......-----------.490.....--..500-.......510..------..-...--520..--.....-530....--------...540---------.....------..550......--------.560.......570.......580..----.....590.......600-----.....-----..610.......620-----........630-.......640-----.........650.......660--.......670.......680.......690......--.700.-......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MD
M
V
K
N
E
W
K
K
L
F
KN
K
I
L
L
L
S
F
V
V
I
L
F
I
P
L
L
Y
A
S
F
F
L
K
S
V
WDPYGKTGD
L
P
V
A
V
VNNDKPVDYNGQTM
D
V
G
D
Q
L
V
T
K
L
KSN-KELDW--NFL
S
K
E
E
A
EQGLKDG
K
Y
Y
M
I
V
TIPKDFS
K
-
N
A
A
S
V
----LDKDPK
K
M
E
L
S
Y
KTN---G
S
L
N
Y
L
G
Q
V
V
S
E
Q
G
A
K
Q
L
K
S
E
V
S
-
A
E
V
T
K
----------
S
Y
------
A
E
A
I
F
D
K
I
K
ESGDG
F
--
A
QAAD---GSGKIKD-
G
L
V--KSQEG
N
K
T
ISTN
L
K
T
LAD------------S
S
L
T
FKDGA
N
T
L
E
V
G
L
K
TYTDGVNTAAAGGDK
L
N
A
G
V
S
T
L
A
A
GV---
G
P
L
K
D
G
V
A
ALDG
G
A
T
K
L
A
S
-
G
---
V
S
T
-
Y
TS
G
--
V
D
T
L
AGGINQAYTG
S
T
A
L
S
D
G
-
L
N
KMNGSV
P
T
L
A
S
G
I
T
Q
LNNG
Q
K
S
L
A
T
G
L
D
S
L
VD--GS------
N
K
L
S
A
G
L
K
E
LDGNLTDKQ
G
K
--
I
A
Q
L
K
Q
G
M
-----
N
D
L
Q
Q
G
I
D
Q
L
N
QSVNG
E
D
A
---
A
L
A
K
Q
L
A
------
T
L
----------
Q
K
S
L
--
S
D
L
Q
N
G
L
-
T
-
F
I
KSNANF
D
A
E
--------
A
I
K
S
----
K
INATAGV
S
A
E
D
K
Q
K
I
I
D
A
I
Q
A
D
L
D
K
E
T
Q
KSA
T
Q
V
------
A
T
V
E
Q
------------
L
Q
S
G
LSGL
D
L
A
-----
A
I
Q
T
Q
V
T
E
--
L
Q
T
G
V
A
-----------
K
I
SAG
Y
Q
AV--HGG
T
N
-
E
A
F
N
S
I
H
Q
A
ING------SG-SQ
T
--
L
LG
G
A
--
N
Q
L
T
A
-
G
L
KSAQA--------GS
A
K
L
V
---------
A
GTNQ------LNSQVP
T
L
T
S
G
--------
V
G
Q
L
AAGS
A
S
M
E
N
G
L
S
K
LNDGGNKLA----SNSGALRSG
A
T
ELQGG
T
N
-----
Q
L
A
AK-----V
P
T
LAG
G
V
N
Q
L
Q
AG------
S
N
Q
L
A
G
G
L
N
QL-SANS
P
K
L
V
-------
S
G
V
G
Q
LADGSSKIADGSSKLAN--G
S
F
QLGDG
L
T
KLTDG
S
T
E
L
T
D
K
L
A
D
G
A
Q
Q
V
KDTKAT--DK
T
F
N
-
M
IAAPTKLAHNEYTHVSNYG
H
A
L
A
P
Y
V
L
S
L
A
L
Y
V
G
A
L
V
F
N
F
I
M
P
I
R
R
VSMEGQ
P
A
Y
K
W
W
L
S
KL
S
L
G
F
V
A
A
V
A
M
A
L
LEG
G
I
M
I
A
LGLR
P
D
S
I
V
E
F
F
G
T
A
I
I
T
A
L
A
Y
M
F
L
I
M
L
L
A
M
TFDNP
G
R
F
I
A
M
V
L
L
I
V
Q
LAGSGGTFPM
P
L
T
G
W
F
F
N
L
I
H
P
FLPM
T
Y
S
I
Y
A
F
R
E
S
L
A
AGMGP
N
V
Y
S
M
S
M
L
I
L
T
I
I
M
V
A
C
V
G
L
L
Y
L
S
M
S
H
L
K
K
R
H
D
A
H
ESALDDNQ
K
L
MALEN
11
PsiBlast_PDB
79.29
22%
31
* C7 *
2WAE
1
PBP2_STRR6
A:
[74-672]
----------------------------------------------------------------------------------------------------------------------------------------------------
N
T
L
K
Q
V
V
S
F
T
R
S
N
K
M
T
A
T
D
L
-
K
E
I
A
K
----------
K
L
------
L
T
Y
V
--
S
I
S
S
P
N
L
T
E
--
R
Q
L
A
D
Y
Y
L
A
D
P
E
I
Y
K
-
K
T
V
--
E
A
L
P
--------------------------
S
E
L
-
Y
N
N
A
V
D
S
V
P
T
S
Q
L
N
Y
T
E
D
E
K
K
E
I
Y
L
F
S
Q
L
N
A
-
V
G
N
F
A
T
G
T
I
A
T
D
P
L
N
D
S
Q
V
A
V
I
A
S
I
S
K
E
M
P
-
G
---
I
S
I
-
S
T
S
W
--
D
R
K
I
-------------
L
E
T
S
-
L
S
S
I
V
G
S
V
S
S
E
K
A
G
L
P
A
-
E
E
A
E
S
Y
L
K
K
G
Y
-
S
L
N
D
RV
G
T
------
S
Y
L
E
K
Q
Y
E
E
V
------
L
Q
G
K
R
P
V
K
E
I
H
L
D
K
-----
H
G
D
M
E
S
V
E
N
I
E
E
G
S
K
G
K
N
I
---
K
L
T
I
D
L
A
F
Q
D
S
V
D
A
L
----------
L
K
S
Y
F
N
S
E
L
G
N
G
G
-
A
---
K
Y
S
E
G
V
Y
A
V
--------
A
L
N
P
----
Q
T
G
A
V
L
S
M
S
G
L
K
H
----
D
L
K
T
G
E
L
T
P
D
S
L
G
T
V
T
N
V
FVPGSV
V
K
A
A
T
------------
I
S
S
G
W
E
N
G
V
L
S
-----
G
N
Q
T
L
T
D
Q
P
I
V
F
Q
G
S
A
-----------
P
I
Y
S
W
Y
K
L
A
--
Y
G
S
F
P
I
T
A
V
E
A
L
E
Y
S
S
N
A
------
Y
V
-
V
Q
T
--
A
L
G
------------
I
M
G
Q
T
--------
Y
Q
P
N
M
F
---------
V
G
T
S
N
------
L
E
S
A
M
G
K
L
R
S
T
--------
F
G
E
Y
G
L
G
S
A
T
---
G
I
D
-
L
P
D
E
S
T
G
L
V
----
P
K
E
Y
N
F
A
N
F
I
T
N
A
F
G
Q
F
D
N
Y
T
P
M
Q
L
A
Q
Y
-----
V
A
T
I
A
N
N
G
V
R
L
A
P
H
IVE
G
I
Y
D
N
N
D
K
G
G
L
G
E
L
I
Q
A
I
D
T
K
E
I
NKVNIS
E
S
D
M
A
I
L
H
Q
G
F
Y
Q
V
S
H
G
T
S
P
L
T
T
--
G
R
-
A
F
S
D
G
A
T
V
S
I
S
G
K
T
G
T
-----------
N
N
T
N
A
V
A
Y
A
P
T
E
N
P
Q
I
A
V
A
V
V
F
P
H
N
T
-
N
L
T
K
N
V
G
P
A
I
A
R
D
I
I
N
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.52
22%
30
- C7 -
2WAD
2
PBP2_STRR6
A:
[74-672]
----------------------------------------------------------------------------------------------------------------------------------------------------
N
T
L
K
Q
V
V
S
F
T
R
S
N
K
M
T
A
T
D
L
-
K
E
I
A
K
----------
K
L
------
L
T
Y
V
--
S
I
S
S
P
N
L
T
E
--
R
Q
L
A
D
Y
Y
L
A
D
P
E
I
Y
K
-
K
T
V
--
E
A
L
P
-------------
E
------------
S
E
L
-
Y
N
N
A
V
D
S
V
P
T
S
Q
L
N
Y
T
E
D
E
K
K
E
I
Y
L
F
S
Q
L
N
A
-
V
G
N
F
A
T
G
T
I
A
T
D
P
L
N
D
S
Q
V
A
V
I
A
S
I
S
K
E
M
P
-
G
---
I
S
I
-
S
T
S
W
--
D
R
K
I
-------------
L
E
T
S
-
L
S
S
I
V
G
S
V
S
S
E
K
A
G
L
P
A
-
E
E
A
E
S
Y
L
K
K
G
Y
-
S
L
N
D
R
V
G
T
------
S
Y
L
E
K
Q
Y
E
E
V
------
L
Q
G
K
R
P
V
K
E
I
H
L
D
K
-----
H
G
D
M
E
S
V
E
N
I
E
E
G
S
K
G
K
N
I
---
K
L
T
I
D
L
A
F
Q
D
S
V
D
A
L
----------
L
K
S
Y
F
N
S
E
L
G
N
G
G
-
A
---
K
Y
S
E
G
V
Y
A
V
--------
A
L
N
P
----
Q
T
G
A
V
L
S
M
S
G
L
K
H
----
D
L
K
T
G
E
L
T
P
D
S
L
G
T
V
T
N
V
FVPGSV
V
K
A
A
T
------------
I
S
S
G
W
E
N
G
V
L
S
-----
G
N
Q
T
L
T
D
Q
P
I
V
F
Q
G
S
A
-----------
P
I
Y
S
W
Y
K
L
A
--
Y
G
S
F
P
I
T
A
V
E
A
L
E
Y
S
S
N
A
------
Y
V
-
V
Q
T
--
A
L
G
------------
I
M
G
Q
T
--------
Y
Q
P
N
M
F
---------
V
G
T
S
N
------
L
E
S
A
M
G
K
L
R
S
T
--------
F
G
E
Y
G
L
G
S
A
T
---
G
I
D
-
L
P
D
E
S
T
G
L
V
----
P
K
E
Y
N
F
A
N
F
I
T
N
A
F
G
Q
F
D
N
Y
T
P
M
Q
L
A
Q
Y
-----
V
A
T
I
A
N
N
G
V
R
L
A
P
H
IVE
G
I
Y
D
N
N
D
K
G
G
L
G
E
L
I
Q
A
I
D
T
K
E
I
NKVNIS
E
S
D
M
A
I
L
H
Q
G
F
Y
Q
V
S
H
G
T
S
P
L
T
T
--
G
R
-
A
F
S
D
G
A
T
V
S
I
S
G
K
T
G
T
------------
N
T
N
A
V
A
Y
A
P
T
E
N
P
Q
I
A
V
A
V
V
F
P
H
N
T
-
N
L
T
K
N
V
G
P
A
I
A
R
D
I
I
N
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.34
23%
68
* C6 *
3WP8
-
?
A:
[29-313]
------------------------------------------------
I
A
V
I
T
S
N
I
T
E
V
V
D
G
N
G
N
K
V
N
I
I
D
Q
V
V
N
T
K
P
D
N
-
K
N
Q
D
S
--
L
F
L
T
Y
D
K
Q
G
Q
E
T
T
D
R
-----
L
T
I
G
Q
T
V
Q
K
M
N
T
D
G
I
KFFH
T
N
A
D
T
S
K
G
D
L
G
T
T
N
D
SSA
G
G
L
N
S
T
A
I
G
V
N
A
I
V
A
N
G
A
D
S
S
V
A
L
G
H
N
T
K
VNGKQ
S
I
A
I
G
S
G
------
A
E
A
L
G
N
Q
S
I
S
I
G
T
G
N
--
K
V
T
G
D
---
H
S
G
A
I
G
D
-
G
T
I
--
V
N
G
A
N
S
Y
S
V
G
N
N
N
Q
V
L
T
D
------------
D
--
T
F
V
L
G
N
N
V
T
K
T
I
A
G
S
V
V
L
G
N
G
S
A
A
T
T
G
----
A
G
E
A
G
Y
A
L
S
V
---
A
T
N
A
D
K
A
A
I
T
K
T
T
S
S
T
G
A
V
-
A
---
V
G
D
-
A
S
S
G
--
I
Y
R
Q
I
T
G
V
A
A
G
S
V
D
S
D
A
V
N
V
A
Q
M
K
Q
I
E
D
K
I
E
E
I
L
S
K
I
Y
H
I
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
59.23
12%
17
- C5 -
2CH7
2
MCP2_THEMA
A:
[1-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
H
M
K
D
V
Q
T
E
T
F
--
S
V
------
A
E
S
I
E
E
I
S
K
A
N
E
E
I
T
N
Q
L
L
G
--
I
S
K
E
M
D
N
I
-----
S
T
R
I
E
S
I
S
A
S
V
Q
E
T
T
A
G
S
E
---
E
I
S
S
A
T
K
------
N
I
----------
A
D
S
A
--
Q
Q
A
A
S
F
A
-
D
-
Q
S
T
Q
L
A
K
E
A
G
D
--------
A
L
K
K
----
V
I
E
V
T
R
M
I
S
N
S
A
K
D
V
E
R
V
V
E
S
F
Q
K
G
A
E
E
I
T
S
F
V
E
T
------
I
N
A
I
A
------------
E
Q
T
N
L
L
A
L
N
A
A
-----
I
E
A
A
R
A
G
E
--
A
G
R
G
F
A
-----------
V
V
A
D
E
I
R
K
L
--
A
E
E
S
Q
-
Q
A
S
E
N
V
R
R
V
V
N
E
------
I
R
-
S
I
A
E
D
A
G
K
V
S
--
S
E
I
T
A
-
R
V
E
E
G
T
K
--------
L
A
D
E
A
D
---------
E
K
L
N
S
------
I
V
G
A
V
E
R
I
N
E
M
--------
L
Q
N
I
A
A
A
I
E
E
Q
T
A
A
V
D
E
I
T
T
A
M
T
E
N
A
----
K
N
A
E
E
I
T
N
S
V
K
E
V
N
A
R
L
Q
-----
E
I
S
A
S
-----
T
E
E
V
T
S
R
V
Q
T
I
R
E
N
------
V
Q
M
L
K
E
I
V
A
R
Y
-
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
58.06
23%
41
* C1 *
1LQ7
-
?
A:
[1-67]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
R
V
K
A
L
E
E
--
K
V
------
K
A
L
E
E
K
V
K
A
L
G
G
G
-----
G
R
--
I
E
E
L
K
K
K
W
-----
E
E
L
K
K
K
I
E
E
L
G
G
--
G
G
E
V
K
---
K
V
E
E
E
V
K
------
K
L
----------
E
E
E
I
--
K
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
55.41
24%
56
- C1 -
4K90
7
ELM_ASPFU
A:
[115-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
A
G
N
F
--
E
Y
N
T
N
---
G
Q
G
G
L
G
N
-
D
Y
V
IL
N
A
Q
D
G
S
G
T
N
N
A
N
F
A
T
P
P
D
G
Q
P
G
R
M
R
M
Y
V
W
T
E
S
T
P
Y
R
D
G
S
F
E
A
G
I
V
I
H
E
Y
T
H
G
L
S
N
R
L
T
G
G
P
A
N
S
N
C
L
N
A
L
E
S
-----
G
G
M
G
E
G
W
S
D
F
M
A
T
A
I
R
L
K
P
-
G
DKR
S
T
D
-
Y
T
M
G
EW
A
S
N
R
A
G
G
I
R
Q
-
Y
P
Y
S
T
S
L
S
T
N
---------
P
L
T
Y
T
S
V
N
S
L
-
N
A
V
H
A
I
G
T
V
W
A
S
M
------------------
L
Y
E
V
L
W
N
L
I
D
K
H
G
K
--
N
D
A
P
K
P
T
L
-----
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
55.23
13%
28
- C2 -
4DVZ
-
CAGA_HELPY
A:
[308-829]
--------------------------------------------------------------------------------------------------------------------------------------------
L
M
---
G
S
H
N
--
G
K
V
S
L
L
Y
A
G
D
K
H
D
W
N
A
T
-
V
G
Y
K
D
----------
N
V
------
A
T
L
I
N
V
H
M
K
-
N
G
S
G
L
--
V
I
A
G
G
---
E
K
G
I
N
N
P
-
S
F
Y
--
L
Y
K
E
D
Q
L
T
G
S
----
Q
R
A
L
------------
S
Q
E
E
I
R
N
K
V
D
F
M
E
F
L
A
Q
N
N
T
K
L
D
N
L
S
E
K
E
K
E
K
---
F
Q
N
E
I
E
D
F
Q
---
K
D
S
K
A
Y
L
D
A
L
G
N
D
R
I
A
F
V
S
K
K
---
D
T
K
-
H
S
A
L
--
I
T
E
F
N
N
G
D
L
S
Y
T
L
K
D
Y
---
E
K
-
N
V
T
L
Q
G
S
L
K
H
D
G
V
M
F
V
D
Y
S
F
N
K
V
A
V
F
N
-
L
P
D
L
-
N
--
N
L
------
A
I
T
S
F
V
R
R
N
L
E
N
K
L
T
A
K
G
L
S
--
L
Q
E
A
N
K
L
I
-----
K
D
F
L
S
S
N
K
E
L
A
G
K
A
L
N
F
N
K
---
A
V
A
E
A
K
S
------
T
------------
G
N
Y
--
D
E
V
K
K
A
Q
-
K
-
D
L
E
K
S
L
R
K
R
E
H
--------
L
E
K
E
----
V
E
K
K
L
E
S
K
S
-
G
N
K
K
A
Q
A
N
S
Q
K
D
E
I
F
A
L
I
N
K
E
A
N
R
D
------
A
R
A
I
A
------------
Y
T
Q
N
L
K
G
I
K
-
R
-----
E
L
S
D
K
L
E
K
--
I
S
K
D
L
K
-----------
D
F
S
K
S
F
D
E
F
K
N
F
S
K
A
E
-
E
T
L
K
A
L
K
G
S
V
K
D
------
L
G
I
N
P
E
--
W
I
S
K
V
--
E
N
L
N
A
-
A
L
N
E
F
K
N
--------
G
D
F
S
K
V
---------
T
Q
A
K
S
------
D
L
E
N
S
V
K
D
V
I
I
--------
N
Q
K
V
T
D
K
V
D
N
L
N
Q
A
V
S
V
A
K
A
M
G
D
F
---------
S
R
V
E
Q
V
L
A
D
L
K
N
F
S
K
-----
E
Q
L
A
Q
-----
Q
A
Q
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
55.03
11%
1
- C2 -
2X0C
-
TLN1_MOUSE
A:
[1352-1659]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
F
T
K
---
H
G
Q
K
E
C
D
------
N
A
----------
L
R
Q
L
--
E
T
V
R
E
L
L
E
N
-
P
V
Q
P
I
N
D
M
S
Y
F
--------
G
C
L
D
----
S
V
M
E
N
S
K
V
L
G
E
A
M
T
G
I
S
Q
N
A
K
N
G
N
L
P
E
F
G
D
A
I
A
T
A
------
S
--
K
A
------------
L
C
G
F
T
E
A
A
A
Q
A
-----
A
Y
L
V
G
V
S
D
--
P
N
S
Q
A
G
-----------
Q
Q
G
L
V
E
P
T
Q
--
F
A
R
A
N
-
Q
A
I
Q
M
A
C
Q
S
L
G
E
------
P
G
-
C
T
-------
Q
--
A
Q
V
L
S
-
A
A
T
I
V
A
K
--------
H
T
S
A
L
C
---------
N
S
C
R
L
------
A
S
A
R
T
A
N
-
P
T
A
--------
K
R
Q
F
V
Q
S
A
K
E
V
A
N
S
T
A
N
L
V
K
T
I
K
A
L
D
----
G
D
F
T
--
E
E
N
R
A
Q
C
R
A
A
T
A
-----
P
L
L
E
A
-----
V
D
N
L
S
A
F
A
S
N
P
E
F
S
------
S
V
P
-
A
Q
I
S
P
E
G
-
R
A
A
M
E
P
I
V
-------
I
S
A
K
T
M
L
E
S
A
G
G
L
I
Q
T
A
R
A
L
A
V
NP
R
D
P
P
R
W
S
V
L
A
G
H
S
R
T
V
S
D
S
I
K
K
L
I
T
S
M
R
D
K
A
P
G
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
54.95
24%
9
- C1 -
3CNI
2
?
A:
[11-114]
------------------------------------------------
Q
K
V
A
I
V
R
E
D
T
G
T
--------
I
A
E
L
A
E
K
A
L
G
N
---
M
V
D
I
VY
A
G
S
D
L
K
E
A
E
E
A
V
K
K
E
K
A
P
A
I
I
V
I
P
K
G
F
S
Q
-
S
L
E
S
---------
G
E
K
A
R
L
E
I
V
W
Y
---
L
R
G
T
G
L
S
E
A
V
S
T
G
T
I
S
S
L
I
E
S
L
K
-
V
Q
L
A
S
----------
F
L
------
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
52.98
23%
45
- C1 -
3K8V
-
?
A:
[44-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
A
G
L
-
A
I
S
D
--
R
M
------
T
A
Q
I
K
G
L
T
Q
A
Q
R
N
A
N
D
G
I
-
S
--
L
A
Q
T
A
E
G
A
L
G
E
I
S
N
N
L
Q
R
I
R
E
L
A
V
Q
A
S
N
G
T
N
T
---
Q
T
D
R
D
--------
A
L
----------
Q
A
E
V
--
T
Q
L
Q
S
E
I
-
Q
-
R
V
A
E
Q
T
S
F
N
G
Q
KLLDGSFN
G
V
Q
F
----
Q
I
G
A
N
A
G
E
T
I
-
G
V
S
K
I
M
N
A
Q
T
A
S
L
G
G
S
L
T
R
T
T
S
T
I
------
D
A
T
D
-----------------
L
T
K
Y
D
T
A
-----
M
A
A
G
D
L
T
I
--
N
G
V
D
V
G
-----------
K
I
D
A
A
S
T
A
-------
Q
-
E
R
A
A
Q
L
T
E
A
I
N
R
------
V
S
-
S
Q
T
--
N
V
G
A
S
--
Y
D
K
T
T
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
51.38
23%
67
- C6 -
3PR7
-
?
A:
[54-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
N
K
I
--
S
G
G
D
N
-
N
T
A
N
G
T
Y
L
T
I
G
G
GDY
N
K
T
K
G
-
R
Y
S
--
T
I
G
G
G
L
F
N
E
A
T
N
-
E
Y
S
T
I
G
S
--------
G
G
Y
N
K
A
KGRYSTIG
G
G
G
Y
N
E
------
A
T
N
Q
Y
S
T
I
G
G
G
--------
D
N
N
T
A
K
G
R
Y
S
T
I
G
G
------
G
G
Y
N
E
A
----
T
I
E
N
S
T
V
G
G
-----
G
G
Y
N
-----
Q
A
K
G
R
-----
N
S
T
V
A
G
G
Y
N
N
E
A
T
G
------
T
D
S
T
I
A
G
G
R
K
N
-
Q
A
-------------
T
G
K
G
S
F
A
A
G
I
D
N
K
A
N
A
D
N
A
V
A
L
--
G
N
K
N
T
I
E
G
E
N
S
V
A
I
G
S
N
N
T
V
K
K
---
G
Q
Q
N
V
F
I
L
G
S
N
--
T
D
T
T
N
-
A
Q
N
G
S
V
L
L
G
H
N
T
A
G
K
A
A
T
I
V
N
S
A
E
V
G
G
L
S
L
T
G
F
A
G
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
50.65
20%
51
- C4 -
2YO1
1
GCN4_YEAST
A:
[42-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
H
A
N
S
------
T
E
E
D
S
------------
L
A
V
G
T
D
S
L
A
M
G
-----
A
K
T
I
V
N
A
D
--
A
G
I
G
I
G
LNTL-------
V
M
A
D
A
I
N
G
I
--
A
I
G
S
N
-
A
R
A
N
H
A
N
S
I
A
M
G
------
N
G
-
S
Q
T
--
T
R
G
A
Q
--
T
D
Y
T
A
Y
N
M
D
T
P
Q
N
--------
S
V
G
E
F
S
---------
V
G
S
E
D
------
G
Q
R
Q
I
T
N
V
A
A
G
SADTDAVN
V
G
Q
L
K
V
T
D
A
Q
V
S
R
N
T
Q
S
I
T
N
----
L
N
----
T
Q
V
S
N
L
D
T
R
V
T
N
I
E
N
G
I
G
-----
D
I
V
T
T
GSTKY
F
K
T
N
T
D
G
A
D
A
N
A
Q
G
------
A
D
S
V
A
I
G
S
G
S
I
-
A
A
A
E
N
S
V
A
-------
L
G
T
N
S
V
A
D
E
A
N
T
V
S
V
G
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.30
20%
62
- C4 -
2YO3
-
GCN4_YEAST
A:
[76-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
T
N
T
D
G
A
D
A
N
A
Q
G
A
D
S
V
A
I
G
S
G
S
I
A
A
A
E
---
N
S
V
A
L
G
T
N
S
V
A
D
E
A
N
T
V
S
V
-
G
---
S
S
T
-
Q
Q
R
R
--
I
T
N
V
A
A
G
V
N
N
--------
T
D
A
-
V
N
V
A
Q
L
K
A
-
S
E
A
G
S
V
R
Y
E
T
N
A
D
G
S
V
N
Y
S
V
L
N
L
G
D
--
G
S
G
G
T
T
R
I
G
N
V
S
A
A
V
N
D
T
D
A
V
------
N
--
Y
A
Q
L
K
R
S
V
-----
E
E
A
N
T
Y
T
D
Q
K
M
G
E
M
N
S
K
I
K
---
G
V
E
N
K
M
K
------
Q
I
----------
E
D
K
I
--
E
E
I
L
S
K
I
-
Y
-
H
I
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
49.78
20%
52
- C4 -
2YO0
1
GCN4_YEAST
A:
[42-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
H
A
N
S
------
T
E
E
D
S
------------
L
A
V
G
T
D
S
L
A
M
G
-----
A
K
T
I
V
N
A
D
--
A
G
I
G
I
G
L
NTL-------
V
M
A
D
A
I
N
G
I
--
A
I
G
S
N
-
A
R
A
N
H
A
N
S
I
A
M
G
------
N
G
-
S
Q
T
--
T
R
G
A
Q
--
T
D
Y
T
A
Y
N
M
D
T
P
Q
N
--------
S
V
G
E
F
S
---------
V
G
S
E
D
------
G
Q
R
Q
I
T
N
V
A
A
G
SADT
D
A
V
N
V
G
Q
L
K
V
T
D
A
Q
V
S
R
N
T
Q
S
I
T
N
----
L
N
----
T
Q
V
S
N
L
D
T
R
V
T
N
I
E
N
G
I
G
-----
D
I
V
T
T
GSTKY
F
K
T
N
T
D
G
A
D
A
N
A
Q
G
------
A
D
S
V
A
I
G
S
G
S
I
-
A
A
A
E
N
S
V
A
-------
L
G
T
N
S
V
A
D
E
A
N
T
V
S
V
G
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
49.40
26%
67
- C4 -
4UT1
11
?
A:
[423-633]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
L
P
------------
T
R
G
A
L
D
G
F
S
L
A
TANGS
A
I
A
A
A
S
P
V
--
L
A
A
G
V
A
TNSGT
G
V
I
S
Q
G
S
V
S
A
G
Y
Q
L
P
--
S
G
T
T
T
-
L
A
Y
N
A
A
S
K
T
L
S
G
FP----
V
G
-
T
T
V
--
T
I
A
G
T
--
P
P
T
S
I
-
N
I
T
S
A
T
T
P
V
P
Y
D
PS
K
G
A
S
M
T
I
---------
S
S
T
T
Q
PAPSGV
M
N
G
V
S
V
S
L
S
-----------
G
T
P
A
D
G
D
Q
F
T
I
G
A
N
K
G
T
N
D
G
R
N
A
L
A
L
S
Q
L
V
N
S
K
T
M
N
N
G
T
T
T
L
T
G
A
--------
Y
A
G
Y
-----
V
N
A
I
G
N
A
A
S
Q
L
K
A
S
------
S
A
A
Q
T
A
L
V
G
Q
I
-
T
-
Q
A
Q
Q
S
V
-------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
48.63
29%
88
- C4 -
4ETP
5
A:
[5-157]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
-
L
K
E
K
I
A
A
L
K
E
K
-----
I
A
A
L
K
E
K
I
-----
K
D
T
E
L
G
M
K
E
L
N
E
I
L
I
K
E
E
T
V
R
R
T
L
H
N
E
L
Q
------
E
L
R
GN
I
R
V
Y
L
R
I
R
P
A
L
--
K
N
L
E
N
S
D
-
T
S
L
I
N
V
N
E
F
D
D
N
S
--------
G
V
Q
S
M
E
V
T
K
I
Q
N
T
A
Q
V
H
E
F
K
F
D
K
I
F
D
--
Q
Q
D
T
N
V
D
V
F
K
E
V
G
Q
L
-----------------------
V
Q
S
S
L
D
G
Y
N
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
48.46
9%
4
* C5 *
4HPQ
-
?
C:
[2-411]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
A
V
--
I
E
K
L
L
E
N
S
-----
R
K
F
L
T
G
A
K
L
I
C
Q
E
S
N
D
H
L
T
---
T
T
K
L
R
I
R
------
E
W
----------
Q
K
F
Q
--
S
K
L
H
F
V
L
-
D
-
C
I
Q
Q
Q
T
K
F
L
S
E
--------
I
L
L
R
----
E
G
I
G
R
N
L
I
E
E
E
W
S
Q
T
V
L
V
R
L
V
N
D
M
K
F
W
Q
N
E
I
T
K
M
M
------
N
K
L
D
N
ITNEIDQQHNSK
L
G
D
F
I
S
R
D
S
S
H
-----
I
L
D
S
K
L
N
E
--
I
P
T
I
R
K
-----------
Q
V
E
N
I
T
R
Q
Y
--
Q
T
M
L
A
-
K
V
Q
S
Q
L
V
E
S
R
M
K
------
G
L
-
R
D
E
--
F
S
E
E
F
--
T
N
E
A
D
-
Q
L
E
Q
E
L
A
--------
D
F
L
K
S
F
---------
T
D
H
F
D
------
K
C
S
A
L
S
S
R
S
V
S
--------
P
E
D
A
Q
N
L
F
E
I
V
E
R
D
D
K
D
L
A
A
I
N
S
L
L
Q
----
D
A
A
I
D
V
A
S
F
V
R
K
V
N
M
L
L
D
-----
E
R
D
A
D
-----
K
A
K
M
Q
A
T
L
S
K
L
L
T
E
------
L
R
K
H
E
E
Y
I
S
V
F
-
E
G
I
S
A
L
I
Q
-------
K
F
K
A
S
C
L
E
D
I
R
Q
T
R
N
L
L
D
F
Y
A
N
--
F
E
R
S
Y
H
N
L
L
K
E
V
K
R
R
K
E
T
A
A
K
L
S
Q
I
L
K
S
C
E
T
Q
L
E
Q
I
--
N
T
A
D
L
-
R
E
R
Q
M
F
L
L
E
N
G
N
Y
L
P
E
T
I
W
P
D
E
I
G
S
L
S
P
L
Y
T
L
N
Y
E
V
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
47.84
21%
32
- C1 -
3CNI
2
?
A:
[11-155]
------------------------------------------------
Q
K
V
A
I
V
R
E
D
T
G
--------
T
I
A
E
L
A
E
K
A
L
G
-
N
M
V
D
I
V
Y
--
A
G
S
D
L
K
E
A
E
E
A
V
K
K
E
K
A
P
A
I
I
V
I
P
K
G
F
S
Q
-
S
L
E
S
---------
G
E
K
A
R
L
E
I
V
W
Y
---
L
R
G
T
G
L
S
E
A
V
S
T
G
T
I
S
S
L
I
E
S
L
K
-
V
Q
L
A
S
----------
F
L
LNDPKK
A
Q
L
L
F
D
P
L
E
I
V
Q
H
T
Y
L
R
G
S
L
F
K
---
N
H
S
P
E
A
I
M
N
V
F
--
Y
S
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
45.55
29%
65
- C1 -
4R7J
2
?
A:
[186-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
D
A
V
K
V
G
I
---
G
P
---
G
S
I
C
----
T
T
R
I
V
S
-
G
---
V
G
V
P
Q
I
S
A
--
I
D
E
C
V
E
E
A
N
K
--
F
G
V
P
V
I
A
D
G
-
G
I
K
Y
S
G
D
I
-------------
A
K
A
L
A
V
G
A
S
S
V
M
I
--
G
S
--------
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
--
Q
Y
K
S
Y
R
G
M
-----
G
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
45.22
29%
64
- C1 -
4MZ1
5
?
A:
[186-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
D
A
V
K
V
G
I
---
G
P
---
G
S
I
C
----
T
T
R
I
V
S
-
G
---
V
G
V
P
Q
I
S
A
--
I
D
E
C
V
E
E
A
N
K
--
F
G
V
P
V
I
A
D
G
-
G
I
K
Y
S
G
D
I
-------------
A
K
A
L
A
V
G
A
S
S
V
M
I
--
G
S
--------
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
--
Q
Y
K
S
Y
R
G
M
-----
G
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------