@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2429: (2016-04-03 )
MKSALELKNVSFSRKRDFEMKNVSASIPEGKITTLIGPNGSGKSTMLRLMMRLLTPDSGEILLNEKNITEIPSKDLAKKMTMLSQAPEGLVDVMVHDLVAYGRLPHRSWLSTLQEEDEAVIHWAIKVCNLEELAYRPLHSLSGGERQRAWLAMALAQKTPILLLDEPTTYLDIAHQLELLDLLVHLNKEYNLTIVLVLHDLNQAAIYSDHVFVCENGQLVKDGSPREVFTTELLRDVFHITADITEKDGKQHIHPLASTRFEY
Atome Classification :
(32 SA)
.........10..-..-.----.-----..-20.-.......30........40........50........60........70-.--...---.-------------...---.80.......-.-90........100-.----.......110.....--..120.......130....--....140.......150.....-----..160........170.......180.......190.......200.......210.......220.......-------230......-------..240.......250.......260.--------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKSALELKNVSFS-RK-R----D-----FE-MKN-VSASIPEG
K
I
T
T
L
IGPNGS
G
K
S
T
M
L
R
L
M
M
R
L
LTPDS
G
E
I
L
LNEKNITE--I--
P
S
K
---
D
-------------
L
A
K
---
K
M
T
M
L
SQAP
E
-
G
-
L
V
D
V
M
V
H
D
L
V
A
Y--G----RLP
H
R
S
W
L
S
T
L
Q
EED--
E
A
V
I
H
W
A
I
K
VC
N
L
-
E
E
L
A
Y
--RPLHSLSGG
E
R
Q
R
A
W
L
A
M
A
L
AQ-----KT
P
-
I
L
L
LDEP
T
T
Y
L
D
I
A
H
Q
L
E
L
L
D
L
L
V
HLNKEY
N
L
T
I
V
L
V
L
HDLNQ
A
A
I
YS
D
H
V
F
V
CEN
G
Q
L
VKDGSP
R
E
V
F
-------
T
-
T
E
L
L
R
D
V
-------
F
H
I
TAD
I
T
E
KDGKQH
I
H
P
L
A
STRFEY--------------------------------------------------------------------------------
21
PsiBlast_CBE
90.05
35%
-131
- C1 -
4G1U
1
HMUV_YERPE
D:
[12-246]
----
L
E
A
S
H
L
H
Y
H
-
V
Q
-
Q
----
Q
-----
A
L
-
I
N
D
-
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
H
L
L
G
Q
N
L
N
S
--
W
--
Q
P
K
---
A
-------------
L
A
R
---
T
R
A
V
M
R
Q
Y
S
E
-
L
-
A
F
P
F
S
V
S
E
V
I
Q
M
--
G
----
R
A
P
Y
G
G
------
S
Q
D
--
R
Q
A
L
Q
Q
V
M
A
Q
T
D
C
-
L
A
L
A
Q
--
R
D
Y
R
V
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
LWQPQ
P
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
-------
N
-
A
E
T
L
T
Q
W
-------
Y
Q
--------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.46
35%
-130
- C1 -
4G1U
1
HMUV_YERPE
C:
[12-246]
----
L
E
A
S
H
L
H
Y
H
-
V
Q
-
Q
----
Q
-----
A
L
-
I
N
D
-
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
H
L
L
G
Q
N
L
N
S
--
W
--
Q
P
K
---
A
-------------
L
A
R
---
T
R
A
V
M
R
Q
Y
S
E
-
L
-
A
F
P
F
S
V
S
E
V
I
Q
M
--
G
----
R
A
P
Y
G
G
------
S
Q
D
--
R
Q
A
L
Q
Q
V
M
A
Q
T
D
C
-
L
A
L
A
Q
--
R
D
Y
R
V
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
WQPQ
P
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
-------
N
-
A
E
T
L
T
Q
W
-------
Y
Q
--------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
83.92
32%
-120
- C1 -
4MKI
4
ECFA2_CALS4
A:
[7-236]
----
I
K
V
E
N
V
S
F
I
-
Y
N
-
E
----
G
TPYAT
V
A
-
L
K
D
-
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
KK
V
--
S
L
K
---
D
-------------
I
R
K
---
Q
V
G
L
V
F
Q
Y
P
E
Y
Q
-
L
F
E
E
T
V
F
K
D
I
A
F
--
G
------
P
S
N
L
G
L
S
--
E
E
E
V
--
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
--
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
-----
R
P
K
-
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
---------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.66
32%
-120
- C1 -
4MKI
4
ECFA2_CALS4
B:
[7-236]
----
I
K
V
E
N
V
S
F
I
-
Y
N
-
E
----
G
TPYAT
V
A
-
L
K
D
-
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
KK
V
--
S
L
K
---
D
-------------
I
R
K
---
Q
V
G
L
V
F
Q
Y
P
E
Y
Q
-
L
F
E
E
T
V
F
K
D
I
A
F
--
G
------
P
S
N
L
G
L
S
--
E
E
E
V
--
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
--
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
-----
R
P
K
-
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
---------------------------------------------------------------------------------------------------------------------------------
75
Fugue
80.38
28%
-100
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
-
Y
P
-
G
----
G
-----
A
R
S
V
R
G
-
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
--
L
--
P
P
Q
---
K
---------------
R
---
N
V
G
L
V
F
Q
N
Y
A
-
L
-
F
Q
H
M
T
V
Y
D
N
V
S
F
--
G
----
L
R
E
K
R
----
V
P
K
D
E
M
--
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
--
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
-----
R
P
Q
-
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
EKPGT
L
F
V
-
A
S
F
I
G
E
S
-------
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
EG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
96
HHSearch
79.41
30%
-119
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[5-236]
-
D
Y
I
L
K
V
E
E
L
N
Y
N
-
Y
S
-
D
G---
T
-----
H
A
-
L
K
G
-
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
D
Y
--
S
R
K
G
I
M
---
K
-------------
L
R
E
---
S
I
G
I
V
F
Q
D
P
D
N
Q
-
L
F
S
A
S
V
Y
Q
D
V
S
F
--
G
----
A
V
N
M
K
L
----
P
E
D
E
I
--
R
K
R
V
D
N
A
L
K
R
T
G
I
-
E
H
L
K
D
--
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
-----
E
P
K
-
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
-------
A
-
E
K
E
---------------------------------------------------------------------------------------------------------------------
99
HHSearch
77.76
29%
-103
- C1 -
2OLJ
4
?
A:
[22-251]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
-
F
G
-
S
----
L
-----
E
V
-
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
KD
T
--
N
L
N
---
K
-------------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
P
---
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-------
D
-
R
P
Q
---------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.50
32%
-136
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[24-254]
-------------------------------
L
K
G
-
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
-
D
--
Y
--
S
R
K
---
G
-------------
I
M
K
L
R
E
S
I
G
I
V
F
Q
D
P
D
-
N
Q
L
F
S
A
S
V
Y
Q
D
V
S
F
--
G
A
V
N
M
K
L
P
--------
E
D
E
I
--
R
K
R
V
D
N
A
L
K
R
T
G
I
-
E
H
L
K
D
--
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
-----
E
P
K
-
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
-------
A
E
K
E
V
I
R
K
V
N
L
R
L
P
R
I
G
H
L
M
E
I
----------------------------------------------------------------------------------------------------
82
HHSearch
76.98
32%
-109
- C1 -
1Z47
1
?
A:
[14-237]
---
T
I
E
F
V
G
V
E
K
I
-
Y
P
G
G
----
A
-----
R
S
-
V
R
G
-
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
--
L
--
P
P
------------------
Q
K
R
---
N
V
G
L
V
F
Q
N
Y
A
-
L
-
F
Q
H
M
T
V
Y
D
N
V
S
F
--
G
----
L
R
E
K
R
V
----
P
K
D
E
M
--
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
--
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
-----
R
P
Q
-
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
-------
E
-
K
P
----------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
76.00
31%
-115
- C1 -
2OUK
1
?
C:
[40-247]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TNLNK--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
74.29
31%
-117
- C1 -
2OLJ
4
?
A:
[40-247]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TN
L
N
K
--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.98
32%
-122
- C1 -
1Z47
1
?
A:
[31-234]
-------------------------------
V
R
G
-
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
--
L
--
P
P
Q
---
K
---------------
R
---
N
V
G
L
V
F
Q
N
Y
A
-
L
-
F
Q
H
M
T
V
Y
D
N
V
S
F
--
G
L
R
E
K
R
V
P
--------
K
D
E
M
--
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
--
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
-----
R
P
Q
-
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
---------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
73.73
31%
-123
- C1 -
3TUI
1
METN_ECOLI
C:
[44-253]
-------------------------------
L
N
N
-
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
--
L
--
S
E
S
---
E
-------------
L
T
K
ARR
Q
I
G
M
I
F
Q
H
F
N
-
L
-
L
S
S
R
T
V
F
G
N
V
A
---------
L
P
-
L
E
L
D
N
T
P
K
D
E
V
--
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
--
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-----
N
P
K
-
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-------
S
-------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.61
31%
-129
- C1 -
2NQ2
-
Y1470_HAEIN
C:
[2-227]
-
N
K
A
L
S
V
E
N
L
G
F
Y
Y
Q
A
-
E
----
N
-----
F
L
-
F
Q
Q
-
L
N
F
D
L
N
K
G
D
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
L
D
L
L
L
G
I
H
R
P
I
Q
G
K
I
--------------------
E
-------------
V
Y
Q
---
S
I
G
F
V
P
Q
F
F
S
-
S
-
P
F
A
Y
S
V
L
D
I
V
L
M
--
G
----
R
S
T
H
I
N
T
F
A
K
P
K
S
H
D
--
Y
Q
V
A
M
Q
A
L
D
Y
L
N
L
-
T
H
L
A
K
--
R
E
F
T
S
L
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
-----
E
C
K
-
L
I
L
L
D
E
P
T
S
A
L
D
L
A
N
Q
D
I
V
L
S
L
L
I
D
L
A
Q
S
Q
N
M
T
V
V
F
T
T
H
Q
P
N
Q
V
V
A
I
A
N
K
T
L
L
L
-
N
K
Q
N
F
K
F
G
E
T
R
N
I
L
-------
T
-
S
E
N
L
T
A
L
-------
F
H
L
-------------------------------------------------------------------------------------------------------
86
HHSearch
73.56
29%
-116
* C1 *
3TUI
1
METN_ECOLI
C:
[23-254]
--
H
M
I
K
L
S
N
I
T
K
V
-
F
H
-
Q
GTRT
I
-----
Q
A
-
L
N
N
-
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
--
L
--
S
E
S
ELT
K
-------------
A
R
R
---
Q
I
G
M
I
F
Q
H
F
N
-
L
-
L
S
S
R
T
V
F
G
N
V
A
L
--
P
----
L
E
L
D
N
T
P
----
K
D
E
V
--
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
--
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-----
N
P
K
-
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-------
S
-
H
-----------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
73.54
32%
-124
- C1 -
1Z47
1
?
B:
[31-234]
-------------------------------
V
R
G
-
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
--
L
--
P
P
Q
---
K
---------------
R
---
N
V
G
L
V
F
Q
N
Y
A
-
L
-
F
Q
H
M
T
V
Y
D
N
V
S
F
--
G
LREK
R
V
P
--------
K
D
E
M
--
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
--
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
-----
R
P
Q
-
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
---------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
73.12
31%
-117
- C1 -
2OUK
1
?
A:
[40-247]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TN
L
N
K
--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
73.02
31%
-116
- C1 -
2OLK
1
?
A:
[40-247]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
T
N
L
N
K
--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
72.89
29%
-117
- C1 -
1VCI
1
?
A:
[13-237]
----
V
K
L
E
N
L
T
-
K
-
R
F
-
G
----
N
-----
F
T
-
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
--
L
--
P
P
K
---
D
---------------
R
---
N
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
PL
K
----
K
F
P
--------
K
D
E
I
--
D
K
R
V
R
W
A
A
E
L
L
Q
I
-
E
E
L
L
N
--
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
-----
E
P
D
-
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
---------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.67
29%
-116
- C1 -
1V43
-
?
A:
[13-237]
----
V
K
L
E
N
L
T
-
K
-
R
F
-
G
----
N
-----
F
T
-
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
--
L
--
P
P
K
---
D
---------------
R
---
N
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
PL
K
----
K
F
P
--------
K
D
E
I
--
D
K
R
V
R
W
A
A
E
L
L
Q
I
-
E
E
L
L
N
--
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
-----
E
P
D
-
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
---------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
72.33
31%
-116
- C1 -
2OLK
1
?
C:
[40-247]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TNLNK--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
72.15
31%
-119
- C1 -
2OLK
2
?
B:
[40-247]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TNLNK--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
71.87
31%
-115
- C1 -
3C4J
3
?
A:
[40-247]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TN
L
N
K
--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
71.63
31%
-122
- C1 -
3C4J
4
?
B:
[40-247]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TNLNK--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
71.56
32%
-107
- C1 -
1B0U
4
HISP_SALTY
A:
[22-241]
-------------------------------
L
K
G
-
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
--
V
--
R
D
K
---
D
GQLKVAD
K
N
Q
L
R
L
L
R
T
---
R
L
T
M
V
F
Q
H
------
F
N
L
W
S
H
M
T
V
L
E
--
N
----
V
M
E
A
P
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
-
G
I
-
D
E
R
A
Q
GK
Y
P
V
H
-
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-----
E
P
D
-
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
-
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
---------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
71.50
31%
-116
- C1 -
2OLK
1
?
D:
[40-247]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TNLNK--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
71.08
31%
-117
- C1 -
2Q0H
4
?
B:
[40-247]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TNL
N
K
--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
71.04
31%
-115
- C1 -
2Q0H
4
?
A:
[40-247]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TN
L
N
K
--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.77
31%
-114
- C1 -
3C41
3
?
J:
[19-226]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TNLNK--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
70.76
31%
-116
- C1 -
2OLJ
3
?
B:
[40-247]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TNLNK--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
69.50
31%
-119
- C1 -
3C41
3
?
K:
[19-226]
-------------------------------
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-------
A
K
---
D
TNLNK--------
V
R
E
---
E
V
G
M
V
F
Q
R
F
N
-
L
-
F
P
H
M
T
V
L
N
N
I
T
L
--
A
----
P
M
K
V
R
K
W
---
P
R
E
K
A
--
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
--
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-----
E
P
K
-
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
---------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
61.12
33%
-124
- C1 -
4HLU
3
ECFA1_THEMA
C:
[12-200]
----
I
E
L
N
S
V
S
F
R
-
Y
N
-
G
----
D
-----
Y
V
-
L
K
D
-
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
-
A
G
E
I
F
L
D
G
S
---------
P
A
D
---
P
FL-----------
L
R
K
---
N
V
G
Y
V
F
Q
N
P
S
-
S
Q
I
I
G
A
T
V
E
E
D
V
A
F
----------
S
L
E
I
M
G
L
D
E
S
E
M
--
R
K
R
I
K
K
V
L
E
L
V
G
L
-
S
G
L
A
A
--
A
D
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
-----
D
T
R
-
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
K
N
E
-
G
K
G
I
I
L
V
T
H
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------