@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2774: (2016-04-07 )
MIELVNVSKKIQDKLILEKVSLSIGAGEFIAVVGESGSGKTTLLNVIGHLDSKDSGQVIINEMEYQTKKEVMTLKKEVLGFIFQNYLLMENETVLENLSITGGENRKLMIEHLEEVGMDESYLAKKVYQLSGGEKQRIAIVRILLKPFQLLLADEPTGNLDDKNKQKIIELFLALKKQGKTIVCVTHDPEISAKADRIIYIEGGEIR
Atome Classification :
(61 SA)
.........--10.-..--..--...20........30........40........50........60-.--------......--.---.-----------70--..--......80...--...-----..90.....-------.--------.----------.100--------..---.--------.-------....--------.---110----..--...-------.---.----120---....---..----.--------130.......140.......150.......160...-....170....-..-.-.180-.......-190.-..-.....200.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIEL
V
N
V
S
K
--
K
I
Q
-
D
K
--
L
I
--
L
E
K
V
S
LSIGA
G
E
F
I
A
V
V
GESGSG
K
T
T
L
L
N
V
I
GHLDSKDS
G
Q
V
I
I
--
N
--------
E
M
E
Y
Q
T
--
K
---
K
-----------
E
V
--
M
T
--
L
K
K
E
V
L
G
F
I
F
Q
--
N
Y
L
-----LMEN
E
T
V
L
E
-------
N
--------
L
----------SI----------TG---G--------E-------N
R
K
L
--------
M
---
I
E
H
----
L
E
--
E
VG-------M---
D
----
E
S
Y
---
L
A
K
K
---
V
Y
----Q--------LSGGEK
Q
R
I
A
I
V
R
I
L
L
K
P
F
Q
L
LLADEPTGNLD
D
K
N
K
-
Q
K
I
I
E
-
L
F
L
A
L
-
K
K-Q-G
K
T
I
-
V
C
V
THDP-E-IS-AK-A
D
R
I
I
Y
IEGGEIR
4
PsiBlast_PDB
94.39
38%
-120
- C1 -
3TIF
7
Y796_METJA
A:
[1-223]
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
E
--
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
--
D
--------
N
I
K
T
N
D
LD
D
---
D
-----------
E
L
--
T
K
--
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
-----
L
I
P
L
L
T
A
L
E
-------
N
--------
V
E
L
PLIFKYR
G
A
M
----------
S
G
---
E
--------
E
-------
R
R
K
R
--------
A
---
L
E
C
----
L
K
--
M
A
E
-------
L
---
E
----
E
R
F
---
A
N
H
K
---
P
N
----
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
-
E
K
I
M
Q
-
L
L
K
K
L
-
N
E
-
E
D
G
K
T
V
-
V
V
V
T
H
D
I
-
N
-
V
A
-
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
-
1
PsiBlast_PDB
94.29
39%
-120
- C1 -
1L2T
4
Y796_METJA
A:
[1-223]
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
E
--
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
--
D
--------
N
I
K
T
N
D
LD
D
---
D
-----------
E
L
--
T
K
--
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
-----
L
I
P
L
L
T
A
L
E
-------
N
--------
V
E
L
PLIFKYR
G
A
M
----------
S
G
---
E
--------
E
-------
R
R
K
R
--------
A
---
L
E
C
----
L
K
--
M
A
E
-------
L
---
E
----
E
R
F
---
A
N
H
K
---
P
N
----
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
-
E
K
I
M
Q
-
L
L
K
K
L
-
N
E
-
E
D
G
K
T
V
-
V
V
V
T
H
D
I
-
N
-
V
A
-
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
-
21
PsiBlast_CBE
93.55
39%
-117
- C1 -
1L2T
4
Y796_METJA
B:
[1-223]
M
I
K
L
K
N
V
T
K
TY
K
M
G
-
E
E
--
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
--
D
--------
N
I
K
T
N
D
LD
D
---
D
-----------
E
L
--
T
K
--
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
-----
L
I
P
L
L
T
A
L
E
-------
N
--------
V
ELPLIFKYRG
A
M
----------
S
G
---
E
--------
E
-------
R
R
K
R
--------
A
---
L
E
C
----
L
K
--
M
A
E
-------
L
---
E
----
E
R
F
---
A
N
H
K
---
P
N
----
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
-
E
K
I
M
Q
-
L
L
K
K
L
-
N
E
-
E
D
G
K
T
V
-
V
V
V
T
H
D
I
-
N
-
V
A
-
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
-
23
PsiBlast_CBE
91.78
38%
-122
- C1 -
3TIF
7
Y796_METJA
B:
[1-223]
M
V
K
L
K
N
V
T
K
TY
K
M
G
-
E
E
--
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
--
D
--------
N
I
K
T
N
D
LD
D
---
D
-----------
E
L
--
T
K
--
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
-----
L
I
P
L
L
T
A
L
E
-------
N
--------
V
ELPLIFKYRG
A
M
----------
S
G
---
E
--------
E
-------
R
R
K
R
--------
A
---
L
E
C
----
L
K
--
M
A
E
-------
L
---
E
----
E
R
F
---
A
N
H
K
---
P
N
----
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
-
E
K
I
M
Q
-
L
L
K
K
L
-
N
E
-
E
D
G
K
T
V
-
V
V
V
T
H
D
I
-
N
-
V
A
-
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
-
5
PsiBlast_PDB
87.49
39%
-115
- C1 -
1F3O
2
Y796_METJA
A:
[2-223]
-
I
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
E
--
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
--
D
--------
N
I
K
T
N
D
LD
D
---
D
-----------
E
L
--
T
K
--
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
-----
L
I
P
L
L
T
A
L
E
-------
N
--------
V
----------
E
L
P
L
I
F
K
YRGAM
S
G
---
E
--------
E
-------
R
R
K
R
--------
A
---
L
E
C
----
L
K
--
M
A
E
-------
L
---
E
----
E
R
F
---
A
N
H
K
---
P
N
----
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
-
E
K
I
M
Q
-
L
L
K
K
L
-
N
E
-
E
D
G
K
T
V
-
V
V
V
T
H
D
I
-
N
-
V
A
-
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
-
116
HHSearch
85.57
38%
-113
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[4-218]
I
L
R
A
E
N
I
K
K
--
V
I
R
-
G
Y
--
E
I
--
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
--
E
--------
G
K
E
V
D
Y
--
T
---
N
-----------
E
K
E
L
S
L
--
L
R
N
R
K
L
G
F
V
F
Q
--
F
H
Y
-----
L
I
P
E
L
T
A
L
E
-------
N
--------
V
----------
I
V
----------
P
M
---
L
--------
K
M
GKP
K
K
E
A
K
E
R
--------
G
---
E
Y
L
----
L
S
--
E
L
G
-------
L
---
G
----
D
-
K
---
L
S
R
K
---
P
Y
----
E
--------
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
-
K
R
V
M
D
-
I
F
L
K
I
-
N
E
-
G
-
G
T
S
I
-
V
M
V
T
H
E
R
-
E
-
L
A
-
E
L
-
T
H
R
T
L
E
M
K
D
G
K
V
V
2
PsiBlast_PDB
85.07
39%
-103
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[9-217]
-----
N
I
K
K
--
V
I
R
-
G
Y
--
E
I
--
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
EG
K
--------
E
V
D
Y
T
N
--
E
---
K
-----------
E
L
--
S
L
--
L
R
N
R
K
L
G
F
V
F
Q
--
F
H
Y
-----
L
I
P
E
L
T
A
L
E
-------
N
--------
V
----------
I
V
----------
P
M
L
K
M
G
--------
K
-------
P
K
K
E
--------
A
---
K
E
R
G
E
Y
L
L
S
--
E
L
G
-------
L
---
G
----
D
K
----
L
S
R
K
---
P
Y
----
E
--------
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
-
K
R
V
M
D
-
I
F
L
K
I
-
N
E
-
G
-
G
T
S
I
-
V
M
V
T
H
E
R
-
E
-
L
A
-
E
L
-
T
H
R
T
L
E
M
K
D
G
K
V
-
3
PsiBlast_PDB
84.49
39%
-105
- C1 -
2PCL
12
LOLD_AQUAE
A:
[9-217]
-----
N
I
K
K
--
V
I
R
-
G
Y
--
E
I
--
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
EG
K
--------
E
V
D
Y
T
N
--
E
---
K
-----------
E
L
--
S
L
--
L
R
N
R
K
L
G
F
V
F
Q
--
F
H
Y
-----
L
I
P
E
L
T
A
L
E
-------
N
--------
V
----------
I
V
----------
P
M
L
K
M
G
--------
K
-------
P
K
K
E
--------
A
---
K
E
R
G
E
Y
L
L
S
--
E
L
G
-------
L
---
G
----
D
K
----
L
S
R
K
---
P
Y
----
E
--------
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
-
K
R
V
M
D
-
I
F
L
K
I
-
N
E
-
G
-
G
T
S
I
-
V
M
V
T
H
E
R
-
E
-
L
A
-
E
L
-
T
H
R
T
L
E
M
K
D
G
K
V
-
22
PsiBlast_CBE
84.26
39%
-105
- C1 -
2PCJ
1
LOLD_AQUAE
B:
[9-217]
-----
N
I
K
K
--
V
I
R
-
G
Y
--
E
I
--
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
EG
K
--------
E
V
D
Y
T
N
--
E
---
K
-----------
E
L
--
S
L
--
L
R
N
R
K
L
G
F
V
F
Q
--
F
H
Y
-----
L
I
P
E
L
T
A
L
E
-------
N
--------
V
----------
I
V
----------
P
M
LKM
G
--------
K
-------
P
K
K
E
--------
A
---
K
E
R
GEYL
L
S
--
E
L
G
-------
L
---
G
----
D
K
----
L
S
R
K
---
P
Y
----
E
--------
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
-
K
R
V
M
D
-
I
F
L
K
I
-
N
E
-
G
-
G
T
S
I
-
V
M
V
T
H
E
R
-
E
-
L
A
-
E
L
-
T
H
R
T
L
E
M
K
D
G
K
V
-
121
HHSearch
82.08
32%
-118
- C1 -
1B0U
4
HISP_SALTY
A:
[7-232]
-
L
H
V
I
D
L
H
K
--
R
Y
G
-
G
H
--
E
V
--
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
--
N
--------
G
Q
N
I
N
L
--
V
---
R
D
KDGQLKVAD
K
N
Q
--
L
R
--
L
L
R
T
R
L
T
M
V
F
Q
--
H
F
N
-----
L
W
S
H
M
T
V
L
E
-------
N
--------
V
----------
M
E
----------
A
P
---
I
QVLGLS
K
H
D
-------
A
R
E
R
--------
A
---
L
K
Y
----
L
A
--
K
V
G
-------
I
---
D
----
E
R
A
---
Q
G
K
Y
---
P
V
----
H
--------
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
-
G
E
V
L
R
-
I
M
Q
Q
L
-
A
E
-
E
-
G
K
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
71
PsiBlast_CBE
79.71
31%
-109
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-217]
-
L
H
I
G
H
L
S
K
--
S
F
Q
-
N
T
--
P
V
--
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
--
S
--------
G
K
T
I
F
S
--
K
---
N
-----------
T
N
--
L
P
--
V
R
E
R
R
L
G
Y
L
V
Q
--
E
G
V
-----
L
F
P
H
L
T
V
Y
R
-------
N
--------
I
----------
A
Y
----------
G
L
---
G
NGKGRTA-
Q
-------
E
R
Q
R
--------
I
---
E
A
M
----
L
E
--
L
T
G
-------
I
---
S
----
E
-
L
---
A
G
R
Y
---
P
H
----
E
--------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
-
R
Q
I
R
E
D
M
I
A
A
L
-
R
A
-
N
-
G
K
S
A
-
V
F
V
S
H
D
R
-
E
-
E
A
-
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
-
107
HHSearch
77.67
32%
-103
- C1 -
3RLF
3
MALK_ECOLI
A:
[3-213]
S
V
Q
L
Q
N
V
T
K
--
A
W
G
-
E
V
--
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
--
G
--------
E
K
R
M
N
D
--
T
---
P
-------------------
P
A
E
R
G
V
G
M
V
F
Q
--
S
Y
A
-----
L
Y
P
H
L
S
V
A
E
-------
N
--------
M
----------
S
F
----------
G
L
---
K
--------
L
A
GAK
K
E
V
I
N
Q
R
--------
V
---
N
Q
V
----
A
E
--
V
L
Q
-------
L
---
A
----
H
-
L
---
L
D
R
K
---
P
K
----
A
--------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
-
V
Q
M
R
I
-
E
I
S
R
L
-
H
K
R
L
-
G
R
T
M
-
I
Y
V
T
H
D
Q
-
V
-
E
A
M
T
L
-
A
D
K
I
V
V
L
D
A
G
R
V
A
101
HHSearch
77.50
33%
-98
- C1 -
1Z47
1
?
A:
[15-225]
-
I
E
F
V
G
V
E
K
--
I
Y
P
G
G
A
--
R
S
--
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
--
G
--------
G
K
R
V
T
D
--
L
---
P
----------------
P
---
Q
K
R
N
V
G
L
V
F
Q
--
N
Y
A
-----
L
F
Q
H
M
T
V
Y
D
-------
N
--------
V
----------
S
F
----------
G
L
---
R
--------
E
K
RVP
K
D
E
M
D
A
R
--------
V
---
R
E
L
----
L
R
--
F
M
R
-------
L
---
E
----
S
-
Y
---
A
N
R
F
---
P
H
----
E
--------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
-
R
E
L
R
T
-
F
V
R
Q
V
-
H
D
E
M
-
G
V
T
S
-
V
F
V
T
H
D
Q
-
E
-
E
A
L
E
V
-
A
D
R
V
L
V
L
H
E
G
N
V
E
41
PsiBlast_CBE
76.66
32%
-91
- C1 -
4KI0
4
?
A:
[4-212]
-
V
Q
L
Q
N
V
T
K
--
A
W
G
-
E
V
--
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
--
G
--------
E
K
R
M
N
D
--
T
---
P
-----------
P
A
--------
E
R
G
V
G
M
V
F
Q
--
S
Y
A
-----
L
Y
P
H
L
S
V
A
E
-------
N
--------
M
----------
S
F
G
L
K
-------
L
A
---
G
--------
A
-------
K
K
E
V
--------
I
N
Q
R
V
N
Q
----
V
A
--
E
V
L
-------
Q
---
L
----
A
H
L
---
L
D
R
K
---
P
K
----
A
--------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
-
K
R
-
L
-
G
R
T
M
-
I
Y
V
T
H
D
Q
V
E
-
A
M
-
T
L
-
A
D
K
I
V
V
L
D
A
G
R
V
-
72
PsiBlast_CBE
76.31
31%
-105
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-222]
-
L
H
I
G
H
L
S
K
--
S
F
Q
-
N
T
--
P
V
--
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
--
S
--------
G
K
T
I
F
S
--
K
---
N
-----------
T
N
--
L
P
--
V
R
E
R
R
L
G
Y
L
V
Q
--
E
G
V
-----
L
F
P
H
L
T
V
Y
R
-------
N
--------
I
----------
A
Y
----------
G
L
---
G
NGKGRT
A
-
Q
-------
E
R
Q
R
--------
I
---
E
A
M
----
L
E
--
L
T
G
-------
I
---
S
----
E
-
L
---
A
G
R
Y
---
P
H
----
E
--------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
-
R
Q
I
R
E
D
M
I
A
A
L
-
R
A
-
N
-
G
K
S
A
-
V
F
V
S
H
D
R
-
E
-
E
A
-
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
-
77
PsiBlast_CBE
76.13
31%
-109
- C1 -
2PMK
1
A:
[14-217]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
A
H
D
F
I
S
E
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
H
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
50
PsiBlast_CBE
76.10
32%
-90
- C1 -
3PUW
5
MALK_ECOLI
B:
[4-222]
-
V
Q
L
Q
N
V
T
K
--
A
W
G
-
E
V
--
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
--
G
--------
E
K
R
M
N
D
--
T
---
P
-----------
P
A
--------
E
R
G
V
G
M
V
F
Q
--
S
Y
A
-----
L
Y
P
H
L
S
V
A
E
-------
N
--------
M
----------
S
F
G
L
K
-------
L
A
---
G
--------
A
-------
K
K
E
V
--------
I
N
Q
R
V
N
Q
----
V
A
--
E
V
L
-------
Q
---
L
----
A
H
L
---
L
D
R
K
---
P
K
----
A
--------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
-
K
R
-
L
-
G
R
T
M
-
I
Y
V
T
H
D
Q
V
E
-
A
M
-
T
L
-
A
D
K
I
V
V
L
D
A
G
R
V
-
74
PsiBlast_CBE
75.67
31%
-110
- C1 -
1B0U
4
HISP_SALTY
A:
[7-231]
-
L
H
V
I
D
L
H
K
--
R
Y
G
-
G
H
--
E
V
--
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
--
N
GQNI
N
L
V
R
D
K
D
G
Q
L
--
K
VAD
K
-----------
N
Q
--
L
R
--
L
L
R
T
R
L
T
M
V
F
Q
--
H
F
N
-----
L
W
S
H
M
T
V
L
E
-------
N
V
M
EAPIQV
L
----------
G
L
----------
S
K
---
H
--------
D
-------
A
R
E
R
--------
A
---
L
K
Y
----
L
A
--
K
V
G
-------
I
---
D
----
E
R
A
---
Q
G
K
Y
---
P
V
----
H
--------
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
-
G
E
V
L
R
-
I
M
Q
Q
L
-
A
E
-
E
-
G
K
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
-
81
PsiBlast_CBE
75.66
31%
-106
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[18-221]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
A
H
D
F
I
S
E
L
---
R
----
E
G
Y
N
T
I
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
H
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
102
HHSearch
75.63
33%
-103
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-223]
A
L
H
I
G
H
L
S
K
--
S
F
Q
-
N
T
--
P
V
--
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
--
S
--------
G
K
T
I
F
S
--
K
---
N
-----------
T
N
--
L
P
--
V
R
E
R
R
L
G
Y
L
V
Q
--
E
G
V
-----
L
F
P
H
L
T
V
Y
R
-------
N
--------
I
----------
A
Y
----------
G
L
---
G
--------
N
GKGRT
A
Q
E
R
Q
R
--------
I
---
E
A
M
----
L
E
--
L
T
G
-------
I
---
S
----
E
-
L
---
A
G
R
Y
---
P
H
----
E
--------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
-
R
Q
I
R
E
-
D
M
I
A
A
L
R
A
-
N
-
G
K
S
A
-
V
F
V
S
H
D
R
-
E
-
E
A
L
Q
Y
-
A
D
R
I
A
V
M
K
Q
G
R
I
L
75
PsiBlast_CBE
75.01
31%
-109
- C1 -
2FF7
1
A:
[18-221]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
A
H
D
F
I
S
E
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
H
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
33
PsiBlast_CBE
74.87
31%
-103
- C1 -
2OLK
1
?
C:
[24-237]
M
I
D
V
H
Q
L
K
K
--
S
F
G
-
S
L
--
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--
D
--------
G
I
N
L
K
A
--
K
---
D
-----------
T
N
--
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
-----
L
F
P
H
M
T
V
L
N
-------
N
--------
I
----------
T
L
----------
A
P
---
M
--------
K
-------
V
R
K
W
--------
P
---
R
E
K
----
A
E
--
A
K
A
-------
M
ELL
D
----
K
V
G
---
L
K
D
K
---
A
H
AYPD
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
S
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-
79
PsiBlast_CBE
74.86
31%
-106
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[18-221]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
AHDFISE
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
H
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
9
PsiBlast_PDB
74.25
31%
-103
- C1 -
2OLK
1
?
A:
[24-237]
M
I
D
V
H
Q
L
K
K
--
S
F
G
-
S
L
--
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--
D
--------
G
I
N
L
K
A
--
K
---
D
-----------
T
N
--
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
-----
L
F
P
H
M
T
V
L
N
-------
N
--------
I
----------
T
L
----------
A
P
---
M
--------
K
-------
V
R
K
W
--------
P
---
R
E
K
----
A
E
--
A
K
A
-------
M
E
L
L
D
----
K
V
G
---
L
K
D
K
---
A
H
AYPD
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
S
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-
78
PsiBlast_CBE
74.24
31%
-107
- C1 -
2FGK
2
D:
[18-221]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
AHDFISE
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
H
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
6
PsiBlast_PDB
73.61
31%
-102
- C1 -
4U00
3
?
A:
[4-216]
I
I
R
I
R
N
L
H
K
--
W
F
G
-
P
L
--
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
--
D
--------
G
L
S
V
K
D
--
D
---
R
-----------
A
L
--
R
E
--
I
R
R
E
V
-
G
M
V
F
Q
--
Q
F
N
-----
L
F
P
H
M
T
V
L
E
-------
N
--------
V
----------
T
L
----------
A
P
---
M
--------
R
-------
V
R
R
W
P
R
E
K
A
E
K
K
A
---
L
E
L
----
L
E
--
R
V
G
I------
L
---
D
----
Q
A
R
-----
K
Y
---
P
A
----
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
D
-
V
M
R
D
L
-
A
Q
-
G
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
-
11
PsiBlast_PDB
73.56
31%
-98
- C1 -
2Q0H
4
?
A:
[24-237]
M
I
D
V
H
Q
L
K
K
--
S
F
G
-
S
L
--
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--
D
--------
G
I
N
L
K
A
--
K
---
D
-----------
T
N
--
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
-----
L
F
P
H
M
T
V
L
N
-------
N
--------
I
----------
T
L
----------
A
P
---
M
--------
K
-------
V
R
K
W
--------
P
---
R
E
K
----
A
E
--
A
K
A
-------
M
E
L
L
D
----
K
V
G
---
L
K
D
K
---
A
H
AYPD
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
S
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-
82
PsiBlast_CBE
72.73
31%
-107
- C1 -
2FFB
1
A:
[18-221]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
A
H
D
F
I
S
E
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
H
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
80
PsiBlast_CBE
72.55
31%
-106
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[18-221]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
AHDFISE
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
H
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
88
PsiBlast_CBE
72.43
31%
-108
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[18-221]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
AHDFISE
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
A
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
91
PsiBlast_CBE
72.42
31%
-109
- C1 -
1XEF
3
D:
[12-215]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
AHDFISE
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
A
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
27
PsiBlast_CBE
72.16
31%
-103
- C1 -
3C4J
4
?
B:
[24-237]
M
I
D
V
H
Q
L
K
K
--
S
F
G
-
S
L
--
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--
D
--------
G
I
N
L
K
A
--
K
---
D
-----------
T
N
--
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
-----
L
F
P
H
M
T
V
L
N
-------
N
--------
I
----------
T
L
----------
A
P
---
M
--------
K
-------
V
R
K
W
--------
P
---
R
E
K
----
A
E
--
A
K
A
-------
M
ELL
D
----
K
V
G
---
L
K
D
K
---
A
H
AYPD
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
S
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-
86
PsiBlast_CBE
71.94
31%
-111
- C1 -
2FGJ
2
D:
[18-221]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
AHDFISE
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
A
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
35
PsiBlast_CBE
71.80
31%
-96
- C1 -
2OLJ
3
?
B:
[24-237]
M
I
D
V
H
Q
L
K
K
--
S
F
G
-
S
L
--
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--
D
--------
G
I
N
L
K
A
--
K
---
D
-----------
T
N
--
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
-----
L
F
P
H
M
T
V
L
N
-------
N
--------
I
----------
T
L
----------
A
P
---
M
--------
K
-------
V
R
K
W
--------
P
---
R
E
K
----
A
E
--
A
K
A
-------
M
ELL
D
----
K
V
G
---
L
K
D
K
---
A
H
AYPD
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
S
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-
92
PsiBlast_CBE
71.76
31%
-120
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[12-215]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
AHDFISE
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
A
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
93
PsiBlast_CBE
71.61
31%
-111
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[12-215]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
AHDFISE
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
A
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
13
PsiBlast_PDB
71.56
31%
-100
- C1 -
3C41
3
?
J:
[3-216]
M
I
D
V
H
Q
L
K
K
--
S
F
G
-
S
L
--
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--
D
--------
G
I
N
L
K
A
--
K
---
D
-----------
T
N
--
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
-----
L
F
P
H
M
T
V
L
N
-------
N
--------
I
----------
T
L
----------
A
P
---
M
--------
K
-------
V
R
K
W
--------
P
---
R
E
K
----
A
E
--
A
K
A
-------
M
ELL
D
----
K
V
G
---
L
K
D
K
---
A
H
AYPD
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
S
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-
94
PsiBlast_CBE
71.29
31%
-110
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[12-215]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
A
H
D
F
I
S
E
L
---
R
----
E
G
Y
N
T
I
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
A
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
83
PsiBlast_CBE
71.09
31%
-106
- C1 -
3B5J
1
A:
[14-217]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
A
H
D
F
I
S
E
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
H
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
32
PsiBlast_CBE
70.54
31%
-99
- C1 -
2OLK
1
?
D:
[24-237]
M
I
D
V
H
Q
L
K
K
--
S
F
G
-
S
L
--
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--
D
--------
G
I
N
L
K
A
--
K
---
D
-----------
T
N
--
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
-----
L
F
P
H
M
T
V
L
N
-------
N
--------
I
----------
T
L
----------
A
P
---
M
--------
K
-------
V
R
K
W
--------
P
---
R
E
K
----
A
E
--
A
K
A
-------
M
ELL
D
----
K
V
G
---
L
K
D
K
---
A
H
AYPD
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
S
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-
34
PsiBlast_CBE
70.41
31%
-103
- C1 -
2OLK
2
?
B:
[24-237]
M
I
D
V
H
Q
L
K
K
--
S
F
G
-
S
L
--
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--
D
--------
G
I
N
L
K
A
--
K
---
D
-----------
T
N
--
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
-----
L
F
P
H
M
T
V
L
N
-------
N
--------
I
----------
T
L
----------
A
P
---
M
--------
K
-------
V
R
K
W
--------
P
---
R
E
K
----
A
E
--
A
K
A
-------
M
ELL
D
----
K
V
G
---
L
K
D
K
---
A
H
AYPD
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
S
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-
87
PsiBlast_CBE
70.36
31%
-112
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[18-221]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
AHDFISE
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
A
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
39
PsiBlast_CBE
70.25
31%
-100
- C1 -
4YMU
2
?
A:
[1-214]
M
I
F
V
N
D
V
Y
K
--
N
F
G
-
S
L
--
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--
D
--------
G
V
K
I
N
N
--
G
---
K
-----------
V
N
--
I
N
--
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
-----
L
F
P
H
L
T
A
I
E
-------
N
--------
I
----------
T
L
----------
A
P
---
V
--------
K
-------
V
K
K
M
--------
N
---
K
K
E
----
A
E
--
E
L
A
-------
V
---
D
L
L
A
K
V
G
L
---
L
D
K
K
DQY
P
I
----
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
K
E
V
L
N
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
-
28
PsiBlast_CBE
70.04
31%
-101
- C1 -
2Q0H
4
?
B:
[24-237]
M
I
D
V
H
Q
L
K
K
--
S
F
G
-
S
L
--
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--
D
--------
G
I
N
L
K
A
--
K
---
D
-----------
T
N
--
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
-----
L
F
P
H
M
T
V
L
N
-------
N
--------
I
----------
T
L
----------
A
P
---
M
--------
K
-------
V
R
K
W
--------
P
---
R
E
K
----
A
E
--
A
K
A
-------
M
E
L
L
D
----
K
V
G
---
L
K
D
K
---
A
H
AYPD
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
S
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-
36
PsiBlast_CBE
70.03
31%
-98
- C1 -
3C41
3
?
K:
[3-216]
M
I
D
V
H
Q
L
K
K
--
S
F
G
-
S
L
--
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--
D
--------
G
I
N
L
K
A
--
K
---
D
-----------
T
N
--
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
-----
L
F
P
H
M
T
V
L
N
-------
N
--------
I
----------
T
L
----------
A
P
---
M
--------
K
-------
V
R
K
W
--------
P
---
R
E
K
----
A
E
--
A
K
A
-------
M
ELL
D
----
K
V
G
---
L
K
D
K
---
A
H
AYPD
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
S
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-
89
PsiBlast_CBE
69.92
31%
-108
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[18-221]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
A
H
D
F
I
S
E
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
A
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
8
PsiBlast_PDB
69.60
31%
-106
- C1 -
2OLJ
4
?
A:
[24-237]
M
I
D
V
H
Q
L
K
K
--
S
F
G
-
S
L
--
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--
D
--------
G
I
N
L
K
A
--
K
---
D
-----------
T
N
--
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
-----
L
F
P
H
M
T
V
L
N
-------
N
--------
I
----------
T
L
----------
A
P
---
M
--------
K
-------
V
R
K
W
--------
P
---
R
E
K
----
A
E
--
A
K
A
-------
M
E
L
L
D
----
K
V
G
---
L
K
D
K
---
A
H
AYPD
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
S
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-
90
PsiBlast_CBE
69.35
31%
-105
- C1 -
2FFA
2
A:
[18-221]
-----------
K
P
D
-
S
P
--
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
--
D
--------
G
H
D
L
A
L
------
A
-----------
D
P
--
N
W
--
L
R
R
Q
V
-
G
V
V
L
Q
--
D
N
V
-----
L
L
-
N
R
S
I
I
D
-------
N
--------
I
----------
S
L
----------
A
N
P--
G
--------
M
-------
S
V
E
K
--------
V
---
I
Y
A
----
A
K
--
L
A
G
A
H
D
F
I
S
E
L
---
R
----
E
G
Y
NTI
V
G
E
Q
---
G
A
----
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
-
N
M
H
K
I
-
C
K
---
G
R
T
V
-
I
I
I
A
A
R
L
-
S
-
T
V
-
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
-
12
PsiBlast_PDB
68.23
31%
-97
- C1 -
3C4J
3
?
A:
[24-237]
M
I
D
V
H
Q
L
K
K
--
S
F
G
-
S
L
--
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--
D
--------
G
I
N
L
K
A
--
K
---
D
-----------
T
N
--
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
-----
L
F
P
H
M
T
V
L
N
-------
N
--------
I
----------
T
L
----------
A
P
---
M
--------
K
-------
V
R
K
W
--------
P
---
R
E
K
----
A
E
--
A
K
A
-------
M
E
L
L
D
----
K
V
G
---
L
K
D
K
---
A
H
AYPD
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
G
E
V
L
S
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-
98
PsiBlast_CBE
67.37
32%
-100
- C1 -
2HYD
3
Y1866_STAAM
A:
[340-553]
-
I
D
I
D
H
V
S
F
--
Q
Y
N
-
D
N
EA
P
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
--
D
--------
G
---
H
N
--
I
---
K
-----------
D
F
--
L
T
G
S
L
R
N
Q
I
-
G
L
V
Q
Q
--
D
N
I
-----
L
F
-
S
D
T
V
K
E
-------
N
--------
I
----------
L
L
----------
G
R
---
P
TAT
D
E
E
V
V
E
-------
A
A
K
M
--------
A
---
N
A
H
----
D
F
--
I
M
N
-------
L
---
P
----
Q
G
Y
DTE
V
G
E
R
---
G
V
----
K
--------
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
-
A
L
D
V
L
-
S
K
-
D
--
R
T
T
-
L
I
V
A
H
R
L
-
S
-
T
I
-
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
-
96
PsiBlast_CBE
66.69
32%
-95
- C1 -
2ONJ
4
Y1866_STAAM
A:
[340-553]
-
I
D
I
D
H
V
S
F
--
Q
Y
N
-
D
N
EA
P
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
--
D
--------
G
---
H
N
--
I
---
K
-----------
D
F
--
L
T
G
S
L
R
N
Q
I
-
G
L
V
Q
Q
--
D
N
I
-----
L
F
-
S
D
T
V
K
E
-------
N
--------
I
----------
L
L
----------
G
R
---
P
TAT
D
E
E
V
V
E
-------
A
A
K
M
--------
A
---
N
A
H
----
D
F
--
I
M
N
-------
L
---
P
----
Q
G
Y
DTE
V
G
E
R
---
G
V
----
K
--------
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
-
A
L
D
V
L
-
S
K
-
D
--
R
T
T
-
L
I
V
A
H
R
L
-
S
-
T
I
-
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
-
95
PsiBlast_CBE
66.60
32%
-97
- C1 -
2ONJ
4
Y1866_STAAM
B:
[340-553]
-
I
D
I
D
H
V
S
F
--
Q
Y
N
-
D
N
EA
P
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
--
D
--------
G
---
H
N
--
I
---
K
-----------
D
F
--
L
T
GS
L
R
N
Q
I
-
G
L
V
Q
Q
--
D
N
I
-----
L
F
-
S
D
T
V
K
E
-------
N
--------
I
----------
L
L
----------
G
R
---
P
TATDEEVV
E
-------
A
A
K
M
--------
A
---
N
A
H
----
D
F
--
I
M
N
-------
L
---
P
----
Q
G
Y
DTE
V
G
E
R
---
G
V
----
K
--------
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
-
A
L
D
V
L
-
S
K
-
D
--
R
T
T
-
L
I
V
A
H
R
L
-
S
-
T
I
-
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
-
38
PsiBlast_CBE
66.50
31%
-94
- C1 -
4YMV
1
?
A:
[1-214]
M
I
F
V
N
D
V
Y
K
--
N
F
G
-
S
L
--
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--
D
--------
G
V
K
I
N
N
--
G
---
K
-----------
V
N
--
I
N
--
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
-----
L
F
P
H
L
T
A
I
E
-------
N
--------
I
----------
T
L
----------
A
P
---
V
--------
K
-------
V
K
K
M
--------
N
---
K
K
E
----
A
E
--
E
L
A
-------
V
---
D
L
L
A
K
V
G
L
---
L
D
K
K
DQY
P
I
----
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
K
E
V
L
N
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
-
67
PsiBlast_CBE
66.37
33%
-110
- C1 -
4MKI
4
ECFA2_CALS4
B:
[27-226]
-----------------------
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
--
N
--------
G
I
D
I
T
D
--
K
---
K
-----------
V
S
--
L
K
--
D
I
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
-----
L
F
E
-
E
T
V
F
K
D
I
A
F
G
P
S
N
--------
L
----------
G
L
----------
S
E
---
E
--------
E
-------
V
K
E
R
--------
V
---
Y
E
A
----
M
E
--
I
V
G
-------
I
---
S
----
K
E
L
---
A
D
K
S
---
P
F
----
E
--------
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
-
Q
E
I
L
N
-
K
I
K
E
I
-
H
D
-
K
-
Y
K
M
I
T
I
L
V
S
H
N
M
-
E
D
I
A
-
R
I
-
A
D
K
I
I
V
M
N
R
G
K
I
-
97
PsiBlast_CBE
66.08
32%
-100
- C1 -
2HYD
3
Y1866_STAAM
B:
[340-553]
-
I
D
I
D
H
V
S
F
--
Q
Y
N
-
D
N
EA
P
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
--
D
--------
G
---
H
N
--
I
---
K
-----------
D
F
--
L
T
GS
L
R
N
Q
I
-
G
L
V
Q
Q
--
D
N
I
-----
L
F
-
S
D
T
V
K
E
-------
N
--------
I
----------
L
L
----------
G
R
---
P
TATDEEVV
E
-------
A
A
K
M
--------
A
---
N
A
H
----
D
F
--
I
M
N
-------
L
---
P
----
Q
G
Y
DTE
V
G
E
R
---
G
V
----
K
--------
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
-
A
L
D
V
L
-
S
K
-
D
--
R
T
T
-
L
I
V
A
H
R
L
-
S
-
T
I
-
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
-
68
PsiBlast_CBE
65.94
33%
-112
- C1 -
4MKI
4
ECFA2_CALS4
A:
[27-226]
-----------------------
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
--
N
--------
G
I
D
I
T
D
--
K
---
K
-----------
V
S
--
L
K
--
D
I
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
-----
L
F
E
-
E
T
V
F
K
D
I
A
F
G
P
S
N
--------
L
----------
G
L
----------
S
E
---
E
--------
E
-------
V
K
E
R
--------
V
---
Y
E
A
----
M
E
--
I
V
G
-------
I
---
S
----
K
E
L
---
A
D
K
S
---
P
F
----
E
--------
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
-
Q
E
I
L
N
-
K
I
K
E
I
-
H
D
-
K
-
Y
K
M
I
T
I
L
V
S
H
N
M
-
E
D
I
A
-
R
I
-
A
D
K
I
I
V
M
N
R
G
K
I
-
17
PsiBlast_PDB
65.74
31%
-97
- C1 -
4YMU
2
?
J:
[1-214]
M
I
F
V
N
D
V
Y
K
--
N
F
G
-
S
L
--
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--
D
--------
G
V
K
I
N
N
--
G
---
K
-----------
V
N
--
I
N
--
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
-----
L
F
P
H
L
T
A
I
E
-------
N
--------
I
----------
T
L
----------
A
P
---
V
--------
K
-------
V
K
K
M
--------
N
---
K
K
E
----
A
E
--
E
L
A
-------
V
---
D
LLAK
V
G
L
---
L
D
K
K
DQY
P
I
----
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
K
E
V
L
N
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
-
70
PsiBlast_CBE
64.75
33%
-98
- C1 -
4HLU
3
ECFA1_THEMA
C:
[12-217]
-
I
E
L
N
S
V
S
F
--
R
Y
N
-
G
D
--
Y
V
--
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
-
A
G
E
I
F
L
--
D
------------
G
S
--
P
---
A
-----------
D
P
--
F
L
--
L
R
K
N
V
-
G
Y
V
F
Q
--
N
P
S
SQIIG
A
T
V
E
E
D
V
A
F
-------
S
--------
L
----------
E
I
----------
M
G
LDE
S
--------
E
-------
M
R
K
R
--------
I
---
K
K
V
----
L
E
--
L
V
G
-------
L
--------
S
G
L
---
A
A
A
D
---
P
L
----
N
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
-
R
E
I
F
Q
-
V
L
E
S
L
-
K
N
-
E
-
G
K
G
I
-
I
L
V
T
H
E
L
-
E
-
Y
L
-
D
D
-
M
D
F
I
L
H
I
S
N
G
T
I
-
18
PsiBlast_PDB
63.01
31%
-97
- C1 -
4YMV
1
?
J:
[1-214]
M
I
F
V
N
D
V
Y
K
--
N
F
G
-
S
L
--
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--
D
--------
G
V
K
I
N
N
--
G
---
K
-----------
V
N
--
I
N
--
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
-----
L
F
P
H
L
T
A
I
E
-------
N
--------
I
----------
T
L
----------
A
P
---
V
--------
K
-------
V
K
K
M
--------
N
---
K
K
E
----
A
E
--
E
L
A
-------
V
---
D
LLAK
V
G
L
---
L
D
K
K
DQY
P
I
----
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-
K
E
V
L
N
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
-
G
-
F
A
-
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
-
99
PsiBlast_CBE
56.00
31%
-100
- C1 -
3VX4
3
?
D:
[51-246]
-----------------------
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
K
G
I
V
R
I
--
N
--------
G
N
D
L
K
V
--
I
---
D
-----------
K
T
---
A
--
L
R
R
H
I
S
Y
L
P
Q
Q
--
A
Y
V
-----
F
--
S
G
S
I
M
D
-------
N
--------
L
----------
V
L
----------
G
A
KE-
G
--------
T
-------
S
Q
E
D
--------
I
---
I
R
A
----
C
E
IA
E
I
R
-------
S
---
D
----
I
E
Q
---
M
P
Q
G
----
Y
----
Q
TELSDGAG
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
-
K
K
I
I
S
-
N
L
L
Q
M
-
T
E
----
K
T
I
-
I
F
V
A
H
R
L
-
S
-
I
S
-
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
-
100
PsiBlast_CBE
53.63
31%
-99
- C1 -
3VX4
3
?
A:
[51-246]
-----------------------
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
K
G
I
V
R
I
--
N
--------
G
N
D
L
K
V
--
I
---
D
-----------
K
T
---
A
--
L
R
R
H
I
S
Y
L
P
Q
Q
--
A
Y
V
-----
F
--
S
G
S
I
M
D
-------
N
--------
L
----------
V
L
----------
G
A
KE-
G
--------
T
-------
S
Q
E
D
--------
I
---
I
R
A
----
C
E
I
A
E
I
R
-------
S
---
D
----
I
E
Q
---
M
P
Q
G
----
Y
----
Q
T
E
L
S
DGAG
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
-
K
K
I
I
S
-
N
L
L
Q
M
-
T
E
----
K
T
I
-
I
F
V
A
H
R
L
-
S
-
I
S
-
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
-