@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu24280: (2016-07-08 )
MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAGGKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTNHKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQVADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIGFQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGGLSLQKDLLYELCDLIAARDH
Atome Classification :
(56 SA)
.........10........20.......-.-.30.-.......40........50...--.....------60..---..--..-..70........80........90........100.......110...--------....-120.......130.......140.......150.....--..160-.....---.--.--170.......180.......190.....-..-.200.-...-....210.......220.......230.......240.......250.......260.......-270......---.---.280.--......290....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
N
K
L
T
S
F
L
A
D
R
K
K
T
I
E
N
Q
L
-
S
V
Y
T
E
KL-D-M
P
D
S
-
L
K
K
S
M
L
Y
S
L
QAGGKR
L
R
P
L
I
V
L
--
A
V
L
N
A------YGKS---EK--DG-IPV
G
C
A
V
E
M
I
H
T
Y
S
L
IHDDLPCMD
D
D
D
LRRGKPTNHKVFG
E
A
T
A
V
LAG--------D
G
L
L
-
T
E
S
F
K
L
I
T
S
H
VS
D
E
V
S
A
E
K
R
L
R
L
V
N
E
L
I
S
AAGTEGMVG--G
Q
V
AD-MEAEN---R--
Q
--
V
T
L
E
E
L
E
S
I
H
E
R
K
T
A
K
L
L
G
F
C
V
-
I
A
G
A
I
-LA-DA-
P
E
-
E
D
I
-
E
T
L
R
T
F
S
S
HI
G
I
G
F
Q
I
R
D
D
ILDLEG
S
E
E
K
I
G
K
RVGSDTTNDKSTYP
S
L
L
SLEGAK
H
K
L
D
V
H
I
K
E
-
A
K
-
R
L
IGGL---
S
---
L
Q
K
D
L
--
L
Y
E
L
C
D
L
IAARDH
1
PsiBlast_PDB
84.69
47%
-73
- C- -
1RTR
-
?
A:
[2-291]
-
T
N
L
P
M
N
K
L
I
D
E
---
V
N
N
E
L
-
S
V
A
I
N
K
S
-
V
-
M
D
T
Q
-
L
E
E
S
M
L
Y
S
L
N
A
G
G
K
R
I
R
P
V
L
L
L
--
L
T
L
D
S
------
L
N
T
E
---
Y
E
--
L
G
-
M
K
S
A
I
A
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
K
L
T
N
H
K
V
Y
G
E
W
T
A
I
L
A
G
--------
D
A
L
L
-
T
K
A
F
E
L
I
S
S
--
D
D
R
L
T
D
E
V
K
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K
V
L
Q
R
L
S
I
A
S
G
H
V
G
M
V
G
--
G
Q
M
L
D
-
M
Q
S
E
G
---
Q
--
P
--
I
D
L
E
T
L
E
M
I
H
K
T
K
T
G
A
L
L
T
F
A
V
-
M
S
A
A
D
-
I
A
-
N
V
-
D
D
-
T
T
K
-
E
H
L
E
S
Y
S
Y
H
L
G
M
M
F
Q
I
K
D
D
L
L
D
C
Y
G
D
E
A
-------------
K
S
T
Y
V
S
L
L
G
K
D
G
A
E
D
K
L
T
Y
H
R
D
A
-
A
V
-
D
E
L
T
Q
I
---
D
---
E
Q
F
N
T
K
H
L
L
E
I
V
D
L
F
Y
S
R
--
89
HHSearch
84.14
47%
-71
- C- -
1RTR
-
?
A:
[7-291]
---------
N
K
L
I
D
E
V
N
N
E
L
-
S
V
A
I
N
K
S
-
V
-
M
D
T
Q
-
L
E
E
S
M
L
Y
S
L
N
A
G
G
K
R
I
R
P
V
L
L
L
--
L
T
L
D
S
------
L
N
T
E
---
Y
E
--
L
G
-
M
K
S
A
I
A
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
K
L
T
N
H
K
V
Y
G
E
W
T
A
I
L
A
G
--------
D
A
L
L
-
T
K
A
F
E
L
I
S
S
D
D
R
--
L
T
D
E
V
K
I
K
V
L
Q
R
L
S
I
A
S
G
H
V
G
M
V
G
--
G
Q
M
L
D
-
M
Q
S
E
G
---
Q
--
P
--
I
D
L
E
T
L
E
M
I
H
K
T
K
T
G
A
L
L
T
F
A
V
-
M
S
A
A
D
-
I
A
-
N
V
-
D
D
-
T
T
K
-
E
H
L
E
S
Y
S
Y
H
L
G
M
M
F
Q
I
K
D
D
L
L
D
C
Y
G
D
E
A
-------------
K
S
T
Y
V
S
L
L
G
K
D
G
A
E
D
K
L
T
Y
H
R
D
A
-
A
V
-
D
E
L
T
Q
I
---
D
EQ-
F
N
T
K
H
--
L
L
E
I
V
D
L
F
Y
S
R
--
88
HHSearch
77.63
39%
-32
- C1 -
3PDE
5
?
A:
[8-298]
----
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
P
L
-
K
Q
A
I
L
A
D
-
S
-
Q
D
A
Q
-
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
--
A
T
M
Q
S
------
L
G
V
T
F
V
-
P
E
--
R
H
-
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
-
T
L
A
F
Q
W
L
T
A
T
D
L
---
P
A
T
M
Q
A
A
L
V
Q
A
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
-
I
Q
S
E
H
---
V
--
N
--
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
-
Q
A
G
L
I
-
L
G
-
Q
A
-
P
E
-
A
Q
W
-
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
-----------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
A
L
I
D
T
I
H
S
-
G
Q
-
A
A
L
Q
G
L
---
P
TS-
T
Q
R
D
D
--
L
A
A
F
F
S
Y
F
D
T
E
--
20
PsiBlast_PDB
76.50
42%
-37
- C1 -
3TS7
2
?
A:
[9-300]
----
L
S
D
F
M
R
S
S
Q
E
R
V
E
R
A
L
-
D
A
R
L
P
A
A
-
D
R
M
P
E
R
-
L
H
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
--
A
T
G
Q
T
------
I
G
V
A
---
A
D
LL
D
G
---
P
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
--------
D
G
L
Q
-
A
L
A
F
H
V
L
A
Q
D
P
S
I
A
V
P
A
E
N
R
I
A
M
I
E
T
L
A
K
A
S
G
P
A
G
M
V
G
--
G
Q
A
I
D
-
L
A
S
V
G
---
K
--
K
--
L
D
L
P
G
L
E
N
M
H
I
R
K
T
G
A
L
I
R
A
S
V
R
L
A
C
L
A
-
R
P
-
G
L
-
P
A
-
E
Q
F
-
D
R
L
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
---------------
K
P
N
Y
P
A
L
L
G
L
S
G
A
K
E
K
A
E
E
M
H
E
A
-
A
L
-
E
S
L
A
G
F
---
G
---
P
E
A
D
L
--
L
R
E
L
A
R
F
I
I
Q
R
--
21
PsiBlast_CBE
76.42
43%
-34
- C1 -
3OAC
4
?
D:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
-
K
E
-
E
E
V
-
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
7
PsiBlast_PDB
75.78
43%
-59
- C1 -
3KRO
4
?
A:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
-
K
E
-
E
E
V
-
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
24
PsiBlast_CBE
75.45
43%
-33
- C1 -
3KRO
4
?
D:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
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K
E
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A
K
L
R
K
F
A
N
C
I
G
L
L
F
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D
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Y
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K
L
I
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V
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S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
25
PsiBlast_CBE
75.06
43%
-36
- C1 -
3KRF
4
?
D:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
-
K
E
-
E
E
V
-
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
96
HHSearch
74.93
39%
-95
- C1 -
5E8K
-
GGPPA_ARATH
A:
[9-303]
--
F
K
F
M
S
Y
M
V
N
K
A
K
S
V
N
K
A
L
-
E
E
A
V
P
L
R
-
E
-
P
E
L
K
-
I
R
E
A
M
R
Y
T
L
L
S
D
G
K
R
V
R
P
M
L
C
L
--
A
A
C
E
L
------
V
G
G
Q
---
E
S
--
T
A
-
M
S
A
A
C
A
I
E
M
L
H
A
S
S
L
I
L
D
D
L
P
C
M
D
N
D
S
L
R
R
G
K
P
T
N
H
I
V
F
G
E
S
I
A
I
L
A
S
--------
Q
A
L
I
-
A
L
A
V
Q
K
T
T
S
S
T
F
A
D
V
P
P
E
R
I
L
K
T
V
Q
E
M
V
K
A
V
--
E
G
L
V
A
--
G
Q
Q
A
D
-
L
A
G
-----------
T
G
L
E
H
L
E
F
I
H
I
H
K
T
A
A
L
L
E
A
A
A
-
V
M
G
A
I
-
M
G
-
G
G
-
S
D
-
E
E
I
-
E
R
L
R
S
Y
A
R
C
I
G
L
M
F
Q
V
V
D
D
V
L
D
-------------------
K
L
T
Y
P
R
L
M
G
V
E
K
S
K
E
Y
A
E
R
L
N
I
E
-
A
R
-
E
H
L
L
G
F
---
D
I--
D
K
V
A
P
--
L
V
S
L
A
D
Y
I
V
N
R
--
6
PsiBlast_PDB
74.89
43%
-60
- C1 -
3KRF
4
?
A:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
-
K
E
-
E
E
V
-
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
4
PsiBlast_PDB
74.67
43%
-57
- C1 -
3KRA
2
?
A:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
-
K
E
-
E
E
V
-
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
22
PsiBlast_CBE
74.31
43%
-37
- C1 -
3OAB
4
?
D:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
-
K
E
-
E
E
V
-
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
13
PsiBlast_PDB
73.85
45%
-77
- C1 -
2J1P
2
GGPPS_SINAL
A:
[37-293]
--------------------------------
P
L
K
-
I
H
E
A
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
V
L
C
I
--
A
A
C
E
L
------
V
G
G
E
---
E
S
--
L
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
I
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
K
V
Y
G
E
D
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
L
A
S
A
T
S
S
E
V
S
P
A
R
V
V
R
A
V
G
E
L
A
K
A
I
G
T
E
G
L
V
A
--
G
Q
V
V
D
-
I
S
---LDL
N
--
N
--
V
G
L
E
H
L
K
F
I
H
L
H
K
T
A
A
L
L
E
A
S
A
-
V
L
G
G
I
-
I
G
-
G
G
-
S
D
-
E
E
I
-
E
R
L
R
K
F
A
R
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
--------------
T
K
--
K
L
T
Y
P
K
L
M
G
L
E
K
S
R
E
F
A
E
K
L
N
T
E
-
A
R
D
Q
L
L
G
F
D
---
S
---
D
K
V
A
P
--
L
L
A
L
A
N
Y
I
A
N
R
Q
N
83
HHSearch
73.52
41%
-21
- C1 -
3TS7
2
?
A:
[7-301]
--
R
S
L
S
D
F
M
R
S
S
Q
E
R
V
E
R
A
L
-
D
A
R
L
P
A
A
-
D
R
M
P
E
R
-
L
H
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
--
A
T
G
Q
T
------
I
G
V
A
---
A
D
--
L
L
-
D
G
P
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
--------
D
G
L
Q
-
A
L
A
F
H
V
L
A
Q
D
P
S
I
A
V
P
A
E
N
R
I
A
M
I
E
T
L
A
K
A
S
G
P
A
G
M
V
G
--
G
Q
A
I
D
-
L
A
S
V
G
---
K
--
K
--
L
D
L
P
G
L
E
N
M
H
I
R
K
T
G
A
L
I
R
A
S
V
-
R
L
A
C
L
-
A
R
P
G
L
-
P
A
-
E
Q
F
-
D
R
L
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
---------------
K
P
N
Y
P
A
L
L
G
L
S
G
A
K
E
K
A
E
E
M
H
E
A
-
A
L
-
E
S
L
A
G
F
---
G
---
P
E
A
D
L
--
L
R
E
L
A
R
F
I
I
Q
R
Q
-
90
HHSearch
73.37
42%
-58
- C1 -
3M0G
-
?
A:
[3-286]
----
L
S
E
R
L
K
E
V
Q
D
A
V
E
T
A
M
-
A
A
A
I
G
R
L
---
P
A
G
D
-
L
R
D
A
M
A
Y
A
A
-
Q
G
G
K
R
L
R
A
F
L
A
I
--
E
S
A
A
I
------
H
G
I
S
---
M
A
--
Q
A
-
M
P
A
A
L
A
V
E
A
L
H
A
Y
S
L
V
H
D
D
M
P
C
M
D
N
D
D
L
R
R
G
L
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
--------
D
A
L
Q
-
T
L
A
F
E
L
C
T
D
P
V
L
G
--
S
A
E
N
R
V
A
L
V
A
A
L
A
Q
A
S
G
A
E
G
M
V
Y
--
G
Q
A
L
D
-
I
A
A
E
T
---
A
A
V
P
--
L
T
L
D
E
I
I
R
L
Q
A
G
K
T
G
A
L
I
S
F
A
A
-
Q
A
G
A
I
-
L
A
-
G
A
-
D
R
-----
G
P
L
T
A
Y
A
T
A
L
G
L
A
F
Q
I
A
D
D
I
L
---------------------
A
T
F
V
S
L
L
G
L
A
G
A
K
S
R
A
A
D
L
V
A
E
-
A
E
-
A
A
L
A
P
Y
---
G
---
E
A
A
S
T
--
L
R
A
C
A
R
Y
V
I
E
---
9
PsiBlast_PDB
73.35
43%
-64
- C1 -
3OAB
4
?
A:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
-
K
E
-
E
E
V
-
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
38
PsiBlast_CBE
73.31
42%
-34
- C1 -
3TS7
3
?
B:
[9-300]
----
L
S
D
F
M
R
S
S
Q
E
R
V
E
R
A
L
-
D
A
R
L
P
A
A
-
D
R
M
P
E
R
-
L
H
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
--
A
T
G
Q
T
------
I
G
V
A
---
A
D
LL
D
G
---
P
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
--------
D
G
L
Q
-
A
L
A
F
H
V
L
A
Q
D
P
S
I
A
V
P
A
E
N
R
I
A
M
I
E
T
L
A
K
A
S
G
P
A
G
M
V
G
--
G
Q
A
I
D
-
L
A
S
V
G
---
K
--
K
--
L
D
L
P
G
L
E
N
M
H
I
R
K
T
G
A
L
I
R
A
S
V
R
L
A
C
L
A
-
R
P
-
G
L
-
P
A
-
E
Q
F
-
D
R
L
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
T
Q
T
L
-----------
K
P
N
Y
P
A
L
L
G
L
S
G
A
K
E
K
A
E
E
M
H
E
A
-
A
L
-
E
S
L
A
G
F
---
G
---
P
E
A
D
L
--
L
R
E
L
A
R
F
I
I
Q
R
--
27
PsiBlast_CBE
73.00
43%
-61
- C1 -
3KRA
1
?
D:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
-
K
E
-
E
E
V
-
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
------------------
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
26
PsiBlast_CBE
72.48
43%
-63
- C1 -
3KRC
1
?
D:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
-
K
E
-
E
E
V
-
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
------------------
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
10
PsiBlast_PDB
72.25
43%
-60
- C1 -
3OAC
-
?
A:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
-
K
E
-
E
E
V
-
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
5
PsiBlast_PDB
72.24
43%
-61
- C1 -
3KRC
1
?
A:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
-
K
E
-
E
E
V
-
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
23
PsiBlast_CBE
70.06
43%
-51
- C1 -
3KRP
3
?
D:
[7-295]
-------
Y
M
L
R
K
A
K
S
V
N
K
A
L
-
E
A
A
V
Q
-
M
-
K
-
E
P
L
K
-
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
E
L
------
V
G
G
D
---
E
S
--
T
A
-
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
--------
D
A
L
L
-
S
F
A
F
E
H
V
A
A
-
A
T
K
G
A
P
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
--
G
Q
V
V
D
-
V
C
S
E
G
---
M
A-
E
--
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
-
V
L
G
A
I
-
L
G
-
G
G
-
K
E
-
E
E
V
-
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
-----------
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
-
A
Q
E
Q
L
L
H
F
H
---
P
---
H
R
A
A
P
--
L
I
A
L
A
N
Y
I
A
Y
R
D
N
85
HHSearch
69.52
42%
-1
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[2-299]
---
D
F
P
Q
Q
L
E
A
C
V
K
Q
A
N
Q
A
L
-
S
R
F
I
A
P
L
P
F
-
Q
N
T
P
-
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
--
A
T
G
H
M
------
F
G
V
S
---
T
N
--
T
L
-
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
--------
D
A
L
Q
-
T
L
A
F
S
I
L
S
D
A
D
M
P
E
V
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
A
G
M
C
G
--
G
Q
A
L
D
-
L
D
A
E
G
---
K
--
H
--
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
-
R
L
G
A
L
-
S
A
-
G
D
-
K
G
R
R
A
L
-
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
-
A
R
-
Q
S
L
K
Q
L
---
A
E
Q
S
L
D
T
S
A
--
L
E
A
L
A
D
Y
I
I
Q
R
N
K
48
PsiBlast_CBE
69.07
42%
2
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[12-298]
-------------
K
Q
A
N
Q
A
L
-
S
R
F
I
A
P
L
-
P
-
F
Q
N
T
P
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
--
A
T
G
H
M
------
F
G
V
S
---
T
N
--
T
L
-
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
--------
D
A
L
Q
-
T
L
A
F
S
I
L
S
D
A
D
M
P
E
V
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
A
G
M
C
G
--
G
Q
A
L
D
-
L
D
A
E
G
---
K
--
H
--
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
-
R
L
G
A
L
-
S
A
G
D
K
-
G
R
-
R
A
L
-
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
-
A
R
-
Q
S
L
K
Q
L
A
E
Q
S
---
L
D
T
S
A
--
L
E
A
L
A
D
Y
I
I
Q
R
N
-
47
PsiBlast_CBE
67.45
42%
-0
- C1 -
1RQJ
5
ISPA_ECOLI
B:
[12-298]
-------------
K
Q
A
N
Q
A
L
-
S
R
F
I
A
P
L
-
P
-
F
Q
N
T
P
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
--
A
T
G
H
M
------
F
G
V
S
---
T
N
--
T
L
-
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
--------
D
A
L
Q
-
T
L
A
F
S
I
L
S
D
A
D
M
P
E
V
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
A
G
M
C
G
--
G
Q
A
L
D
-
L
D
A
E
G
---
K
--
H
--
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
-
R
L
G
A
L
-
S
A
G
D
K
-
G
R
-
R
A
L
-
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
-
A
R
-
Q
S
L
K
Q
L
A
E
Q
S
---
L
D
T
S
A
--
L
E
A
L
A
D
Y
I
I
Q
R
N
-
45
PsiBlast_CBE
66.50
42%
0
* C1 *
1RQI
5
ISPA_ECOLI
B:
[13-299]
-------------
K
Q
A
N
Q
A
L
-
S
R
F
I
A
P
L
-
P
-
F
Q
N
T
P
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
--
A
T
G
H
M
------
F
G
V
S
---
T
N
--
T
L
-
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
--------
D
A
L
Q
-
T
L
A
F
S
I
L
S
D
A
D
M
P
E
V
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
A
G
M
C
G
--
G
Q
A
L
D
-
L
D
A
E
G
---
K
--
H
--
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
-
R
L
G
A
L
-
S
A
G
D
K
-
G
R
-
R
A
L
-
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
-
A
R
-
Q
S
L
K
Q
L
A
E
Q
S
---
L
D
T
S
A
--
L
E
A
L
A
D
Y
I
I
Q
R
N
-
46
PsiBlast_CBE
65.91
42%
2
- C1 -
1RQI
6
ISPA_ECOLI
A:
[13-299]
-------------
K
Q
A
N
Q
A
L
-
S
R
F
I
A
P
L
-
P
-
F
Q
N
T
P
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
--
A
T
G
H
M
------
F
G
V
S
---
T
N
--
T
L
-
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
--------
D
A
L
Q
-
T
L
A
F
S
I
L
S
D
A
D
M
P
E
V
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
A
G
M
C
G
--
G
Q
A
L
D
-
L
D
A
E
G
---
K
--
H
--
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
-
R
L
G
A
L
-
S
A
G
D
K
-
G
R
-
R
A
L
-
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
-
A
R
-
Q
S
L
K
Q
L
A
E
Q
S
---
L
D
T
S
A
--
L
E
A
L
A
D
Y
I
I
Q
R
N
-
29
PsiBlast_CBE
64.16
44%
-6
- C1 -
3PDE
4
?
D:
[36-286]
------------------------------------
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
--
A
T
M
Q
S
------
L
G
V
T
FVP
E
R
--
H
W
-
R
P
V
-
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
-
T
L
A
F
Q
W
L
T
A
---
T
D
L
P
A
T
M
Q
A
A
L
V
Q
A
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
-
I
Q
S
E
H
---
V
--
N
--
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
-
Q
A
G
L
I
-
L
G
-
Q
A
-
P
E
-
A
Q
W
-
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
P
A
---------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
A
L
I
D
T
I
H
S
-
G
Q
-
A
A
L
Q
G
L
PT-
S
---
T
Q
R
D
----------------
15
PsiBlast_PDB
64.15
44%
-8
- C1 -
3PDE
5
?
A:
[36-286]
------------------------------------
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
--
A
T
M
Q
S
------
L
G
V
T
F
V
P
E
R
--
H
W
-
R
P
V
-
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
-
T
L
A
F
Q
W
L
T
A
---
T
D
L
P
A
T
M
Q
A
A
L
V
Q
A
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
-
I
Q
S
E
H
---
V
--
N
--
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
-
Q
A
G
L
I
-
L
G
-
Q
A
-
P
E
-
A
Q
W
-
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
-----------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
A
L
I
D
T
I
H
S
-
G
Q
-
A
A
L
Q
G
L
PT-
S
---
T
Q
R
D
----------------
94
HHSearch
63.54
37%
-27
- C1 -
4LLS
6
?
A:
[26-310]
------
Q
R
L
D
A
A
A
A
A
V
Q
A
H
F
-
D
K
V
L
A
A
F
-
E
--
P
L
P
-
I
V
E
A
M
A
H
A
-
T
S
G
G
K
R
L
R
G
F
L
V
L
--
E
T
A
R
L
------
H
D
I
A
---
A
G
--
E
A
-
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
--------
D
A
L
Q
-
T
L
A
F
E
L
V
T
H
P
G
A
S
-
A
S
A
E
V
R
A
D
L
A
L
S
L
A
R
A
S
G
A
Q
G
M
V
L
--
G
Q
A
L
D
-
I
A
A
E
T
---
A
R
A
P
--
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
-
Q
A
G
A
R
-
L
A
-
Q
A
-
D
T
-----
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
-
A
C
-
D
S
L
A
T
Y
---
G
---
A
K
A
D
T
--
L
R
E
T
A
R
F
V
V
R
R
T
-
92
HHSearch
62.73
39%
0
- C1 -
4LFG
5
?
A:
[5-286]
------------
L
K
K
I
D
Q
T
I
-
H
A
F
Y
C
E
K
A
V
-
I
S
E
K
-
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
--
E
V
I
E
A
------
L
Q
I
P
L--
T
E
--
S
H
-
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
--------
D
S
L
F
-
L
D
A
F
G
M
L
A
E
T
D
F
---
P
T
D
V
T
V
D
L
V
R
S
L
S
S
A
S
G
T
F
G
M
V
G
--
G
Q
M
L
D
-
M
A
A
E
G
---
K
--
K
--
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
F
-
W
A
A
A
R
-
V
A
-
Q
L
-
D
E
-
N
L
L
-
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
Q
I
L
D
E
S
L
D
Q
-
A
E
-
A
I
L
R
K
L
---
S
---
D
E
I
A
F
--
A
P
Q
K
I
L
S
L
I
E
R
L
-
81
HHSearch
62.28
38%
-61
- C1 -
4F62
2
?
A:
[2-292]
-
V
M
N
L
K
Q
F
S
T
Y
T
Q
S
R
V
D
Q
Y
L
-
E
Q
Q
L
S
D
Y
-
A
-
P
A
N
Q
-
L
H
N
A
M
R
Y
S
L
F
-
G
G
K
R
I
R
P
M
L
T
Y
--
A
S
A
Q
L
------
V
G
D
I
---
S
S
--
L
T
-
D
A
S
A
A
A
L
E
S
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
N
-------
P
T
C
H
I
Q
F
D
E
A
T
A
I
L
A
G
--------
D
A
L
Q
-
T
F
A
F
E
L
L
S
N
P
T
S
--
A
Q
P
E
L
A
I
K
L
I
Q
E
L
V
V
A
S
G
R
N
G
M
I
T
--
G
Q
M
I
D
-
L
S
S
E
N
---
K
--
N
--
I
S
L
A
E
L
E
Q
M
H
V
H
K
T
G
A
L
I
K
A
S
V
-
R
M
G
A
L
-
S
T
-
G
Q
V
K
P
-
E
Q
L
-
A
K
L
D
A
Y
A
H
A
I
G
L
A
F
Q
V
Q
D
D
I
I
D
L
T
----------------
N
K
A
T
Y
P
K
L
L
G
L
D
G
A
K
A
L
V
V
R
L
H
E
Q
-
A
I
-
A
Q
I
S
E
F
---
G
---
D
K
S
Q
P
--
L
T
D
L
A
N
Y
I
I
D
---
32
PsiBlast_CBE
61.99
44%
-16
- C1 -
3M9U
6
?
C:
[36-286]
------------------------------------
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
--
A
T
M
Q
S
------
L
G
V
T
FVP
E
R
--
H
W
-
R
P
V
-
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
-
T
L
A
F
Q
W
L
T
A
---
T
D
L
P
A
T
M
Q
A
A
L
V
Q
A
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
-
I
Q
S
E
H
---
V
--
N
--
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
-
Q
A
G
L
I
-
L
G
-
Q
A
-
P
E
-
A
Q
W
-
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
--------------
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
A
L
I
D
T
I
H
S
-
G
Q
-
A
A
L
Q
G
L
PT-
S
---
T
Q
R
D
----------------
31
PsiBlast_CBE
61.16
44%
-7
- C1 -
3PDE
4
?
B:
[36-286]
------------------------------------
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
--
A
T
M
Q
S
------
L
G
V
T
FVP
E
R
--
H
W
-
R
P
V
-
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
-
T
L
A
F
Q
W
L
T
A
---
T
D
L
P
A
T
M
Q
A
A
L
V
Q
A
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
-
I
Q
S
E
H
---
V
--
N
--
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
-
Q
A
G
L
I
-
L
G
-
Q
A
-
P
E
-
A
Q
W
-
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
-----------
D
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
A
L
I
D
T
I
H
S
-
G
Q
-
A
A
L
Q
G
L
PT-
S
---
T
Q
R
D
----------------
17
PsiBlast_PDB
59.43
41%
9
- C1 -
4LFG
5
?
A:
[3-269]
----------
D
K
L
K
K
I
D
Q
T
I
H
A
F
Y
C
E
K
A
-
V
-
I
S
E
K
-
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
--
E
V
I
E
A
------
L
Q
I
P
---
L
T
--
E
S
H
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
--------
D
S
L
F
-
L
D
A
F
G
M
L
A
E
---
T
D
F
P
T
D
V
T
V
D
L
V
R
S
L
S
S
A
S
G
T
F
G
M
V
G
--
G
Q
M
L
D
-
M
A
A
E
G
---
K
--
K
--
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
F
-
W
A
A
A
R
-
V
A
-
Q
L
-
D
E
-
N
L
L
-
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
Q
I
L
D
E
S
L
D
Q
-
A
E
-
A
I
L
R
K
L
---
S
-----------------------
35
PsiBlast_CBE
59.40
41%
9
- C1 -
4LFE
5
?
B:
[3-269]
----------
D
K
L
K
K
I
D
Q
T
I
H
A
F
Y
C
E
K
A
-
V
-
I
S
E
K
-
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
--
E
V
I
E
A
------
L
Q
I
P
---
L
T
--
E
S
H
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
--------
D
S
L
F
-
L
D
A
F
G
M
L
A
E
---
T
D
F
P
T
D
V
T
V
D
L
V
R
S
L
S
S
A
S
G
T
F
G
M
V
G
--
G
Q
M
L
D
-
M
A
A
E
G
---
K
--
K
--
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
F
-
W
A
A
A
R
-
V
A
-
Q
L
-
D
E
-
N
L
L
-
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
Q
I
L
D
E
S
L
D
Q
-
A
E
-
A
I
L
R
K
L
---
S
-----------------------
34
PsiBlast_CBE
59.23
41%
9
- C1 -
4LFG
5
?
B:
[3-269]
----------
D
K
L
K
K
I
D
Q
T
I
H
A
F
Y
C
E
K
A
-
V
-
I
S
E
K
-
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
--
E
V
I
E
A
------
L
Q
I
P
---
L
T
--
E
S
H
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
--------
D
S
L
F
-
L
D
A
F
G
M
L
A
E
---
T
D
F
P
T
D
V
T
V
D
L
V
R
S
L
S
S
A
S
G
T
F
G
M
V
G
--
G
Q
M
L
D
-
M
A
A
E
G
---
K
--
K
--
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
F
-
W
A
A
A
R
-
V
A
-
Q
L
-
D
E
-
N
L
L
-
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
Q
I
L
D
E
S
L
D
Q
-
A
E
-
A
I
L
R
K
L
---
S
-----------------------
30
PsiBlast_CBE
58.80
44%
-9
- C1 -
3PDE
5
?
C:
[36-286]
------------------------------------
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
--
A
T
M
Q
S
------
L
G
V
T
FVP
E
R
--
H
W
-
R
P
V
-
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
-
T
L
A
F
Q
W
L
T
A
---
T
D
L
P
A
T
M
Q
A
A
L
V
Q
A
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
-
I
Q
S
E
H
---
V
--
N
--
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
-
Q
A
G
L
I
-
L
G
-
Q
A
-
P
E
-
A
Q
W
-
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
----------------
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
Q
A
L
I
D
T
I
H
S
-
G
Q
-
A
A
L
Q
G
L
PT-
S
---
T
Q
R
D
----------------
16
PsiBlast_PDB
58.38
41%
-6
- C1 -
4LFE
3
?
A:
[3-269]
----------
D
K
L
K
K
I
D
Q
T
I
H
A
F
Y
C
E
K
A
-
V
-
I
S
E
K
-
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
--
E
V
I
E
A
------
L
Q
I
P
---
L
T
--
E
S
H
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
--------
D
S
L
F
-
L
D
A
F
G
M
L
A
E
---
T
D
F
P
T
D
V
T
V
D
L
V
R
S
L
S
S
A
S
G
T
F
G
M
V
G
--
G
Q
M
L
D
-
M
A
A
E
G
---
K
--
K
--
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
F
-
W
A
A
A
R
-
V
A
-
Q
L
-
D
E
-
N
L
L
-
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
----------------
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
Q
I
L
D
E
S
L
D
Q
-
A
E
-
A
I
L
R
K
L
---
S
-----------------------
19
PsiBlast_PDB
57.71
40%
-50
- C1 -
4F62
2
?
A:
[18-292]
-------------
Q
Y
L
E
Q
Q
L
-
S
D
Y
A
P
A
------
N
Q
-
L
H
N
A
M
R
Y
S
L
F
-
G
G
K
R
I
R
P
M
L
T
Y
--
A
S
A
Q
L
------
V
G
D
I
---
S
S
--
L
T
-
D
A
S
A
A
A
L
E
S
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
N
-------
P
T
C
H
I
Q
F
D
E
A
T
A
I
L
A
G
--------
D
A
L
Q
-
T
F
A
F
E
L
L
S
N
P
T
S
A
Q
--
P
E
L
A
I
K
L
I
Q
E
L
V
V
A
S
G
R
N
G
M
I
T
--
G
Q
M
I
D
-
L
S
S
E
N
---
K
--
N
--
I
S
L
A
E
L
E
Q
M
H
V
H
K
T
G
A
L
I
K
A
S
V
-
R
M
G
A
L
S
T
G
-
Q
V
-
K
P
-
E
Q
L
-
A
K
L
D
A
Y
A
H
A
I
G
L
A
F
Q
V
Q
D
D
I
I
D
L
T
----------------
N
K
A
T
Y
P
K
L
L
G
L
D
G
A
K
-
A
L
V
V
R
L
H
E
Q
A
I
-
A
Q
I
S
E
F
---
G
---
D
K
S
Q
P
--
L
T
D
L
A
N
Y
I
I
D
---
36
PsiBlast_CBE
57.23
40%
-57
- C1 -
4F62
2
?
B:
[18-292]
-------------
Q
Y
L
E
Q
Q
L
-
S
D
Y
A
P
A
------
N
Q
-
L
H
N
A
M
R
Y
S
L
F
-
G
G
K
R
I
R
P
M
L
T
Y
--
A
S
A
Q
L
------
V
G
D
I
---
S
S
--
L
T
-
D
A
S
A
A
A
L
E
S
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
---------------
F
D
E
A
T
A
I
L
A
G
--------
D
A
L
Q
-
T
F
A
F
E
L
L
S
N
P
T
S
A
Q
--
P
E
L
A
I
K
L
I
Q
E
L
V
V
A
S
G
R
N
G
M
I
T
--
G
Q
M
I
D
-
L
S
S
E
-------
N
--
I
S
L
A
E
L
E
Q
M
H
V
H
K
T
G
A
L
I
K
A
S
V
-
R
M
G
A
L
S
T
G
-
Q
V
-
K
P
-
E
Q
L
-
A
K
L
D
A
Y
A
H
A
I
G
L
A
F
Q
V
Q
D
D
I
I
D
L
------------------
K
A
T
Y
P
K
L
L
G
L
D
G
A
K
-
A
L
V
V
R
L
H
E
Q
A
I
-
A
Q
I
S
E
F
---
G
---
D
K
S
Q
P
--
L
T
D
L
A
N
Y
I
I
D
---
41
PsiBlast_CBE
55.63
41%
-17
- C1 -
4LLS
6
?
B:
[60-311]
----------------------------------------------
S
G
G
K
R
L
R
G
F
L
V
L
--
E
T
A
R
L
------
H
D
I
A
---
A
G
--
E
A
-
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
--------
D
A
L
Q
-
T
L
A
F
E
L
V
T
-
H
P
G
A
S
A
S
A
E
V
R
A
D
L
A
L
S
L
A
R
A
S
G
A
Q
G
M
V
L
--
G
Q
A
L
D
-
I
A
A
E
T
---
A
--
R
AP
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
-
Q
A
G
A
R
-
L
A
-
Q
A
-----
D
T
-
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
-
A
C
-
D
S
L
A
T
Y
---
G
---
A
K
A
D
T
--
L
R
E
T
A
R
F
V
V
R
R
T
H
39
PsiBlast_CBE
55.36
41%
-16
- C1 -
4LLT
5
?
B:
[60-311]
----------------------------------------------
S
G
G
K
R
L
R
G
F
L
V
L
--
E
T
A
R
L
------
H
D
I
A
---
A
G
--
E
A
-
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
--------
D
A
L
Q
-
T
L
A
F
E
L
V
T
-
H
P
G
A
S
A
S
A
E
V
R
A
D
L
A
L
S
L
A
R
A
S
G
A
Q
G
M
V
L
--
G
Q
A
L
D
-
I
A
A
E
T
---
A
--
R
A
P
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
-
Q
A
G
A
R
-
L
A
-
Q
A
-----
D
T
-
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
-
A
C
-
D
S
L
A
T
Y
---
G
---
A
K
A
D
T
--
L
R
E
T
A
R
F
V
V
R
R
T
H
40
PsiBlast_CBE
54.05
41%
-17
- C1 -
4LLT
5
?
A:
[60-311]
----------------------------------------------
S
G
G
K
R
L
R
G
F
L
V
L
--
E
T
A
R
L
------
H
D
I
A
---
A
G
--
E
A
-
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
--------
D
A
L
Q
-
T
L
A
F
E
L
V
T
-
H
P
G
A
S
A
S
A
E
V
R
A
D
L
A
L
S
L
A
R
A
S
G
A
Q
G
M
V
L
--
G
Q
A
L
D
-
I
A
A
E
T
---
A
--
R
AP
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
-
Q
A
G
A
R
-
L
A
-
Q
A
-----
D
T
-
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
-
A
C
-
D
S
L
A
T
Y
---
G
---
A
K
A
D
T
--
L
R
E
T
A
R
F
V
V
R
R
T
H
42
PsiBlast_CBE
52.59
41%
-18
- C1 -
4LLS
6
?
A:
[60-311]
----------------------------------------------
S
G
G
K
R
L
R
G
F
L
V
L
--
E
T
A
R
L
------
H
D
I
A
---
A
G
--
E
A
-
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
--------
D
A
L
Q
-
T
L
A
F
E
L
V
T
-
H
P
G
A
S
A
S
A
E
V
R
A
D
L
A
L
S
L
A
R
A
S
G
A
Q
G
M
V
L
--
G
Q
A
L
D
-
I
A
A
E
T
---
A
--
R
A
P
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
-
Q
A
G
A
R
-
L
A
-
Q
A
-----
D
T
-
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
-
A
C
-
D
S
L
A
T
Y
---
G
---
A
K
A
D
T
--
L
R
E
T
A
R
F
V
V
R
R
T
H
58
PsiBlast_CBE
44.75
32%
-109
- C1 -
3WJO
2
?
A:
[52-258]
------------------------------------------
Y
I
V
S
G
G
G
K
R
I
R
P
M
I
A
V
--
L
A
A
R
A
------
V
G
Y
E
---
G
N
--
A
H
-
V
T
I
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
D
M
R
R
G
K
A
T
A
N
A
A
F
G
N
A
A
S
V
L
V
G
--------
D
F
I
Y
-
T
R
A
F
Q
M
M
T
S
-----
L
G
S
L
K
V
L
E
V
M
S
E
A
V
N
V
I
-
A
E
G
E
V
-----
L
Q
L
-
M
N
----------------
N
Y
M
R
V
I
Y
S
K
T
A
R
L
F
E
A
A
A
-
Q
C
S
G
I
-
L
A
-
G
C
-
T
P
-
E
E
E
-
K
G
L
Q
D
Y
G
R
Y
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
A
--------
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
A
M
--------------------------------------------------
53
PsiBlast_CBE
42.34
38%
-9
- C1 -
3Q1O
5
?
C:
[43-273]
------------------------------------
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
--
A
V
L
C
A
LVGQKD
Y
S
N
Q
---
Q
T
--
E
Y
-
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
--------
D
A
L
N
-
T
Y
S
F
E
L
L
S
N
A
L
---
L
E
S
H
I
I
V
E
L
I
K
I
L
S
A
N
G
G
I
K
G
M
I
L
--
G
Q
A
L
D
-
C
Y
F
E
N
---
T
--
P
--
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
-
I
M
G
L
V
-
A
S
-
G
I
-
K
D
-
E
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
A
--
K
N
S
F
V
N
L
L
G
L
E
R
A
N
N
---------------------------------------------
54
PsiBlast_CBE
41.48
38%
-7
- C1 -
3Q1O
3
?
B:
[43-273]
------------------------------------
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
--
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
---
Q
T
--
E
Y
-
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
--------
D
A
L
N
-
T
Y
S
F
E
L
L
S
N
A
L
---
L
E
S
H
I
I
V
E
L
I
K
I
L
S
A
N
G
G
I
K
G
M
I
L
--
G
Q
A
L
D
-
C
Y
F
E
N
---
T
--
P
--
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
-
I
M
G
L
V
-
A
S
-
G
I
-
K
D
-
E
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
A
--
K
N
S
F
V
N
L
L
G
L
E
R
A
N
N
---------------------------------------------
55
PsiBlast_CBE
40.62
38%
-7
- C1 -
3Q1O
4
?
A:
[43-273]
------------------------------------
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
--
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
---
Q
T
--
E
Y
-
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
--------
D
A
L
N
-
T
Y
S
F
E
L
L
S
N
A
L
---
L
E
S
H
I
I
V
E
L
I
K
I
L
S
A
N
G
G
I
K
G
M
I
L
--
G
Q
A
L
D
-
C
Y
F
E
N
---
T
--
P
--
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
-
I
M
G
L
V
-
A
S
-
G
I
-
K
D
-
E
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
A
--
K
N
S
F
V
N
L
L
G
L
E
R
A
N
N
---------------------------------------------
52
PsiBlast_CBE
36.14
38%
-0
- C1 -
3Q1O
3
?
D:
[43-273]
------------------------------------
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
--
A
V
L
C
A
LVGQKD
Y
S
N
Q
---
Q
T
--
E
Y
-
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
--------
D
A
L
N
-
T
Y
S
F
E
L
L
S
N
A
L
---
L
E
S
H
I
I
V
E
L
I
K
I
L
S
A
N
G
G
I
K
G
M
I
L
--
G
Q
A
L
D
-
C
Y
F
E
N
---
T
--
P
--
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
-
I
M
G
L
V
-
A
S
-
G
I
-
K
D
-
E
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
S
A
--
K
N
S
F
V
N
L
L
G
L
E
R
A
N
N
---------------------------------------------
62
PsiBlast_CBE
33.42
31%
-52
- C1 -
4GP2
5
?
B:
[17-249]
---------------
V
E
K
A
L
-
V
R
Y
L
-
S
I
-
G
-
L
A
E
D
-
F
R
E
A
V
L
Y
Q
V
K
T
G
G
K
R
L
R
P
L
L
T
L
--
A
A
A
E
A
------
V
S
G
Q
---
W
R
--
P
A
-
L
P
A
A
A
I
V
E
L
I
H
N
Y
S
L
I
Y
D
D
I
--
I
D
R
G
D
V
R
R
G
L
P
T
V
R
K
A
F
G
D
N
A
A
I
L
V
G
I
W
Y
R
E
A
I
E
E
A
V
L
D
T
P
K
P
T
L
F
A
K
E
V
A
E
V
I
K
A
I
D
E
G
E
R
L
D
I
L
F
E
A
A
G
R
S
D
P
Y
F
--------
V
Q
A
R
W
---
R
--
E
--
V
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
L
I
A
A
A
A
-
K
W
G
V
L
-
S
V
-
S
D
-
D
R
-
G
L
A
-
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
D
------
E
I
G
K
D
I
K
E
H
K
-----------------------------------------------------------
66
PsiBlast_CBE
31.44
34%
-43
- C1 -
3OYR
4
?
B:
[61-265]
--------------------------------------------
I
A
A
G
G
K
R
L
R
P
L
M
T
V
--
A
A
A
R
L
------
A
G
A
D
---
N
D
--
H
F
-
Q
K
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
--
V
V
D
G
S
Q
L
R
R
G
K
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
--------
D
F
L
F
-
A
R
A
F
E
L
M
V
-----
E
T
N
S
M
K
A
L
E
I
L
-----
A
R
A
S
R
V
I
A
E
--
G
E
V
L
Q
L
M
R
S
H
D
---
L
--
N
--
L
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
-
E
A
G
A
V
-
S
A
-
G
V
-
D
V
-
A
K
S
-
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
G
G
A
T
E
T
L
G
K
N
A
G
D
D
F
R
E
G
K
A
T
L
P
L
L
L
A
I
--------------------------------------------------
64
PsiBlast_CBE
30.67
31%
-49
- C1 -
4GP1
3
?
A:
[17-249]
---------------
V
E
K
A
L
-
V
R
Y
L
-
S
I
-
G
-
L
A
E
D
-
F
R
E
A
V
L
Y
Q
V
K
T
G
G
K
R
L
R
P
L
L
T
L
--
A
A
A
E
A
------
V
S
G
Q
---
W
R
--
P
A
-
L
P
A
A
A
I
V
E
L
I
H
N
Y
S
L
I
Y
D
D
I
--
I
D
R
G
D
V
R
R
G
L
P
T
V
R
K
A
F
G
D
N
A
A
I
L
V
G
I
W
Y
R
E
A
I
E
E
A
V
L
D
T
P
K
P
T
L
F
A
K
E
V
A
E
V
I
K
A
I
D
E
G
E
R
L
D
I
L
F
E
A
A
G
R
S
D
P
Y
F
--------
V
Q
A
R
W
---
R
--
E
--
V
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
L
I
A
A
A
A
-
K
W
G
V
L
-
S
V
-
S
D
-
D
R
-
G
L
A
-
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
-------
E
I
G
K
D
I
K
E
H
K
-----------------------------------------------------------
63
PsiBlast_CBE
29.19
31%
-48
- C1 -
4GP2
5
?
A:
[17-249]
---------------
V
E
K
A
L
-
V
R
Y
L
-
S
I
-
G
-
L
A
E
D
-
F
R
E
A
V
L
Y
Q
V
K
T
G
G
K
R
L
R
P
L
L
T
L
--
A
A
A
E
A
------
V
S
G
Q
---
W
R
--
P
A
-
L
P
A
A
A
I
V
E
L
I
H
N
Y
S
L
I
Y
D
D
I
--
I
D
R
G
D
V
R
R
G
L
P
T
V
R
K
A
F
G
D
N
A
A
I
L
V
G
I
W
Y
R
E
A
I
E
E
A
V
L
D
T
P
K
P
T
L
F
A
K
E
V
A
E
V
I
K
A
I
D
E
G
E
R
L
D
I
L
F
E
A
A
G
R
S
D
P
Y
F
--------
V
Q
A
R
W
---
R
--
E
--
V
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
L
I
A
A
A
A
-
K
W
G
V
L
-
S
V
-
S
D
-
D
R
-
G
L
A
-
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
D
P
K
K
F
G
K
E
I
G
K
D
I
K
E
H
K
-----------------------------------------------------------
67
PsiBlast_CBE
25.42
31%
-0
- C1 -
3AQC
5
HEXB_MICLU
D:
[30-252]
---------------------------------
E
T
-
I
N
K
A
A
H
H
I
L
S
S
G
G
K
R
V
R
P
M
F
V
L
LS
G
F
L
N
D
------
T
Q
K
D
-------
D
L
-
I
R
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
--------
H
F
L
L
-
A
R
A
L
Q
N
I
A
T
-----
I
N
N
S
K
----
F
H
Q
I
F
S
K
T
I
L
E
V
C
F
G
EF
D
Q
M
A
D
---
R
F
N
---
Y
--
P
--
V
S
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
-
H
L
G
A
L
-
S
S
-
Q
L
-
D
E
-
Q
S
T
-
Y
H
I
K
Q
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
A
I
A
N
L
K
E
Q
D
D
------------------------------------------
68
PsiBlast_CBE
23.58
31%
-0
- C1 -
3AQC
4
HEXB_MICLU
B:
[30-252]
---------------------------------
E
T
-
I
N
K
A
A
H
H
I
L
S
S
G
G
K
R
V
R
P
M
F
V
L
L
S
G
F
L
N
D
------
T
Q
K
D
-------
D
L
-
I
R
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
--------
H
F
L
L
-
A
R
A
L
Q
N
I
A
T
-----
I
N
N
S
K
----
F
H
Q
I
F
S
K
T
I
L
E
V
C
F
G
E
F
D
Q
M
A
D
---
R
F
N
---
Y
--
P
--
V
S
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
-
H
L
G
A
L
-
S
S
-
Q
L
-
D
E
-
Q
S
T
-
Y
H
I
K
Q
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
A
I
A
N
L
K
E
Q
D
D
------------------------------------------